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Caroline Sévoz-Couche, Charly Brouillard
Serotonin plays a modulatory role in central control of the autonomic nervous system (ANS). The nucleus tractus solitarii (NTS) in the medulla is an area of viscerosomatic integration innervated by both central and peripheral serotonergic fibers. Influences from different origins therefore trigger the release of serotonin into the NTS and exert multiple influences on the ANS. This major influence on the ANS is also mediated by activation of several receptors in the NTS. In particular, the NTS is the central zone with the highest density of serotonin3 (5-HT3) receptors...
April 27, 2016: Neuroscience and Biobehavioral Reviews
Lakshmi Vas, Sushama Phanse, Renuka Pai
UNLABELLED: We present a new perspective of neuromyopathy in pancreatic cancer pain (PCP) referral to bodywall; proposal of new rationale to include ultrasound guided dry needling (USGDN) of body wall muscles as an effective adjunct to neurolytic coeliac plexus block (NCPB) or splanchnic nerve radiofrequency ablation (SRF) for comprehensive interventional management. METHODS: PCP response to SRF in 2 patients and NCPB in 3 patients was documented on numerical rating scale (NRS) on post procedure days 3 and 15...
January 2016: Indian Journal of Palliative Care
K E Farrell, M M Rank, S Keely, A M Brichta, B A Graham, R J Callister
Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Therefore, we developed an in vivo preparation to make patch-clamp recordings from superficial dorsal horn (SDH) neurons receiving colonic inputs in naïve male mice...
March 1, 2016: Neuroscience
Chris T Carter
BACKGROUND: This article describes and discusses the case of an adult female with cholecystitis characterized on initial presentation as acute thoracolumbar pain. CASE PRESENTATION: A 34-year-old female presented for care with a complaint of acute right sided lower thoracic and upper lumbar pain with associated significant hyperalgesia and muscular hypertonicity. The patient was examined, referred, and later diagnosed by use of ultrasound imaging. CONCLUSION: Despite many initial physical examination findings of musculoskeletal dysfunction, this case demonstrates the significance of visceral referred pain, viscerosomatic hyperalgesia & hypertonicity, and how these neurological processes can mimic mechanical pain syndromes...
2015: Chiropractic & Manual Therapies
Chao Huang, Zhi Luo, Christer Hogstrand, Feng Chen, Xi Shi, Qi-Liang Chen, Yu-Feng Song, Ya-Xiong Pan
The present study was conducted to determine the effect and mechanism of waterborne Zn exposure influencing hepatic lipid deposition and metabolism in javelin goby Synechogobius hasta. S. hasta were exposed to four waterborne Zn concentrations (Zn 0.005 [control], 0.18, 0.36 and 0.55 mg l(-1) , respectively) for 60 days. Sampling occurred at days 20, 40 and 60, respectively. Zn exposure increased Zn content, declined hepatic lipid content and reduced viscerosomatic and hepatosomatic indices and lipogenic enzyme activities, including 6-phosphogluconate dehydrogenase (6PGD), glucose-6-phosphate dehydrogenase (G6PD), malic enzyme (ME) and fatty acid synthase (FAS)...
July 2016: Journal of Applied Toxicology: JAT
Daryl I Smith, Alexander Hawson, Lynnie Correll
No abstract text is available yet for this article.
November 2015: Regional Anesthesia and Pain Medicine
Kriton Grigorakis
Species diversification in Mediterranean mariculture involves various important fish that contribute to the diet of many human populations. These include meagres (Sciaenidae), flatfishes, mullets, and various sparids. Their quality aspects are discussed in this review (yields, fillet proximate composition and lipid quality). Their filleting yield is mostly 40-45%. The viscerosomatic index ranges from 1.5 to 14%, depending on species. Flatfishes' and meagres' low muscle fat contents, differentiate them from the rest of the farmed species...
October 15, 2015: Critical Reviews in Food Science and Nutrition
Anthony Johnson, Casey Ligon, Beverley Greenwood-Van Meerveld
No abstract text is available yet for this article.
November 2015: Psychoneuroendocrinology
A C Johnson, L Tran, B Greenwood-Van Meerveld
Gastrointestinal nociception is exacerbated by chronic stress through an unknown mechanism. The amygdala is a key nucleus involved in the autonomic and neuroendocrine responses to stress. The goal of this study was to test the hypothesis that prolonged exposure of the central amygdala (CeA) to stress or the stress hormone cortisol (or corticosterone in rats) induces nociceptive behaviors mediated by corticotropin-releasing factor (CRF) within the CeA. We selectively knocked down CRF in the CeA via antisense oligodeoxynucleotides (ASO) in animals with targeted, stereotaxically placed corticosterone (CORT) micropellets or following repeated water avoidance stress (WAS)...
2015: Translational Psychiatry
Ling-Ling Yu, Liang Li, Pei-Jing Rong, Bing Zhu, Qing-Guang Qin, Hui Ben, Guo-Fu Huang
The purpose of this study was to explore the mechanism of acupoints sensitization phenomenon at the spinal and medulla levels. Experiments were performed on adult male Sprague-Dawley rats and visceral noxious stimuli was generated by colorectal distension (CRD). The activities of wide dynamic range (WDR) and subnucleus reticularis dorsalis (SRD) neurons were recorded. The changes of the reactions of WDR and SRD neurons to electroacupuncture (EA) on acupoints of "Zusanli-Shangjuxu" before and after CRD stimulation were observed...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
D K Prusator, B Greenwood-Van Meerveld
BACKGROUND: Evidence exists to suggest that early life stress (ELS), such as neglect or abuse has profound effects on the developing brain. The current study tests the hypothesis that ELS in the form of neonatal limited nesting (LN) may serve as a predisposing factor for the development of altered nociceptive processing and comorbid increases in anxiety-like behavior in adulthood. METHODS: Both male and female neonatal Sprague-Dawley rats were subjected to LN from postnatal day (PND) 2-9, while a control group was exposed to standard cage bedding...
January 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Huaxin Niu, Yudong Jia, Peng Hu, Zhen Meng, Jilin Lei
This study investigated the growth performance and non-specific immunity in sub-adult turbot fed with graded levels of vitamin E (0, 120, 240, 480 and 960 mg kg(-1)) for 15 weeks. Results showed that the final weight, specific growth rate, nitro blue tetrazolium positive leucocytes of head kidney, phagocytic index, serum lysozyme activity and superoxide dismutase activity significantly increased with increasing vitamin E levels. The highest values were recorded in the diet with 480 mg kg(-1) vitamin E. However, no significant differences in the hepatosomatic index, viscerosomatic index and survival rate were found among all dietary treatment...
December 2014: Fish & Shellfish Immunology
Marinez Moraes de Oliveira, Tainá Ribeiro, Tamira Maria Orlando, Dênio Garcia Silva de Oliveira, Mariana Martins Drumond, Rilke Tadeu Fonseca de Freitas, Priscila Vieira Rosa
The goal of the present work was to study the reproductive performance of Nile Tilapia (Oreochromis niloticus) female broodstock fed diets containing different levels of crude protein (CP). Two hundred and forty Nile tilapia (O. niloticus) were used at an average age of 30 months, with 180 females and 60 males. The broodstock were lodged separately in masonry tanks with continuous water flow. The females were stocked in thirty tanks with dimensions of 8 m(3) in a completely randomized design consisting of five treatments and six replications...
November 10, 2014: Animal Reproduction Science
Chao Huang, Qi-Liang Chen, Zhi Luo, Xi Shi, Ya-Xiong Pan, Yu-Feng Song, Mei-Qin Zhuo, Kun Wu
The present study was conducted to determine the time-course of waterborne chronic copper (Cu) exposure effects influencing hepatic lipid deposition and metabolism in javelin goby Synechogobius hasta and their mechanisms. S. hasta were exposed to four waterborne Cu concentrations (2 (control), 18, 38 and 55 μg Cu/l) for 60 days. Sampling occurred on day 30 and day 60, respectively. Survival decreased and hepatic Cu content increased with increasing Cu levels. On day 30, Cu exposure increased hepatic lipid content, viscerosomatic index (VSI) and hepatosomatic index (HSI), and activities of lipogenic enzymes (6PGD, G6PD, ME, ICDH and FAS) as well as the mRNA levels of 6PGD, G6PD, ME, FAS, ACCα, LPL, PPARγ and SREBP-1 in the liver...
October 2014: Aquatic Toxicology
Roshni Ramachandran, Tony L Yaksh
Migraine pain represents sensations arising from the activation of trigeminal afferents, which innervate the meningeal vasculature and project to the trigeminal nucleus caudalis (TNC). Pain secondary to meningeal input is referred to extracranial regions innervated by somatic afferents that project to homologous regions in the TNC. Such viscerosomatic convergence accounts for referral of migraine pain arising from meningeal afferents to particular extracranial dermatomes. Botulinum toxins (BoNTs) delivered into extracranial dermatomes are effective in and approved for treating chronic migraine pain...
September 2014: British Journal of Pharmacology
Mariano Serrao, Francesca Cortese, Gaia Fragiotta, Antonio Luigi Pastore, Giovanni Palleschi, Gianluca Coppola, Antonio Carbone, Francesco Pierelli
OBJECTIVE: To examine the viscerosomatic interaction between bladder afferents and somatic nociception we evaluated the effect of bladder filling on the nociceptive withdrawal reflex (NWR) in 21 healthy subjects. METHODS: NWR was evoked in the lower and upper limbs by stimulating the sural and index finger digital nerves, respectively, while simultaneously recording EMG activity in the biceps femoris and biceps brachialis. NWR pain-related perception was quantified on a 10-point pain scale...
November 2014: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Xiang-he Liu, Chao-xia Ye, Ji-dan Ye, Bi-duan Shen, Chun-yan Wang, An-li Wang
The effect of dietary amylose/amylopectin (AM/AP) ratio on growth, feed utilization, digestive enzyme activities, plasma parameters, and postprandial blood glucose responses was evaluated in juvenile obscure puffer, Takifugu obscurus. Five isonitrogenous (430 g kg(-1) crude protein) and isolipidic (90 g kg(-1) crude lipid) diets containing an equal starch level (250 g kg(-1) starch) with different AM/AP ratio diets of 0/25, 3/22, 6/19, 9/16 and 12/13 were formulated. Each experimental diet was fed to triplicate groups (25 fish per tank), twice daily during a period of 60 days...
October 2014: Fish Physiology and Biochemistry
Yu-Feng Song, Zhi Luo, Ya-Xiong Pan, Xu Liu, Chao Huang, Qi-Liang Chen
The present study was performed to determine the effects of single and combined exposure of copper (Cu) and cadmium (Cd) on lipogenic metabolism and metal element composition of javelin goby Synechogobius hasta. Two hundred and forty uniform-sized S. hasta (initial mean weight 20.3 ± 0.3 g [mean ± SEM throughout]; initial body length 15.2 ± 0.2 cm) were randomly assigned to 12 fiberglass tanks (water volume 300 l) with 20 fish/tank. The fish were exposed to four treatments with different Cu and Cd concentration for 30 days, respectively: (1) control (without extra Cu and Cd addition), (2) Cu (nominal concentrations of 77 μg/l), (3) Cd (79 μg/l), and (4) Cu + Cd (Cu/Cd coexposure)...
August 2014: Archives of Environmental Contamination and Toxicology
Hans Törnblom, Lukas Van Oudenhove, Jan Tack, Magnus Simrén
BACKGROUND AND AIMS: Rectal sensory and motor interactions in patients with IBS have not been studied in detail. The aim of this study was to evaluate fasting and postprandial rectal sensorimotor characteristics and their interactions in IBS compared with healthy controls. DESIGN: We included 274 patients with IBS and 34 controls. All subjects underwent a rectal barostat study before and 60 min after a standardised liquid meal (800 kcal; 60% fat). Sensory thresholds, intensity of sensations, viscerosomatic referral and compliance were measured...
September 2014: Gut
Bahram Falahatkar, Samaneh Poursaeid, Bahman Meknatkhah, Hossein Khara, Iraj Efatpanah
Juvenile stellate sturgeon Acipenser stellatus were intraperitoneally injected with estradiol-17β (E2; 0 and 5 mg/kg fish) to investigate the possibility of sex reversal and also determine the changes in biochemical parameters. Five-month-old fish (40.9 ± 1.1 g) were injected every 3-week interval during a 190-day trial. At the termination of the experiment, final weight and other growth parameters including weight gain and specific growth rate, hepatosomatic and viscerosomatic indices were not affected by repetitive injection of E2...
April 2014: Fish Physiology and Biochemistry
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