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interleukin 33

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https://www.readbyqxmd.com/read/28073178/polyclonal-and-monoclonal-antibodies-for-induction-therapy-in-kidney-transplant-recipients
#1
REVIEW
Penny Hill, Nicholas B Cross, A Nicholas R Barnett, Suetonia C Palmer, Angela C Webster
BACKGROUND: Prolonging kidney transplant survival is an important clinical priority. Induction immunosuppression with antibody therapy is recommended at transplantation and non-depleting interleukin-2 receptor monoclonal antibodies (IL2Ra) are considered first line. It is suggested that recipients at high risk of rejection should receive lymphocyte-depleting antibodies but the relative benefits and harms of the available agents are uncertain. OBJECTIVES: We aimed to: evaluate the relative and absolute effects of different antibody preparations (except IL2Ra) when used as induction therapy in kidney transplant recipients; determine how the benefits and adverse events vary for each antibody preparation; determine how the benefits and harms vary for different formulations of antibody preparation; and determine whether the benefits and harms vary in specific subgroups of recipients (e...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28070318/piceatannol-exhibits-anti-inflammatory-effects-on-macrophages-interacting-with-adipocytes
#2
Takayuki Yamamoto, Yongjia Li, Yuki Hanafusa, Yu-Sheng Yeh, Hiroko Maruki-Uchida, Shinpei Kawakami, Masahiko Sai, Tsuyoshi Goto, Tatsuhiko Ito, Teruo Kawada
Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in RAW264...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28067797/unconventional-pathways-of-secretion-contribute-to-inflammation
#3
REVIEW
Michael J D Daniels, David Brough
In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional secretion. Unconventionally secreted proteins often have vital roles in cell and organism function such as inflammation. Amongst the best-studied inflammatory unconventionally secreted proteins are interleukin (IL)-1β, IL-1α, IL-33 and high-mobility group box 1 (HMGB1)...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28063327/serum-levels-of-fibroblast-growth-factor-23-are-elevated-in-patients-with-active-lupus-nephritis
#4
Aline L Resende, Rosilene M Elias, Myles Wolf, Luciene M Dos Reis, Fabiana G Graciolli, Geuza D Santos, Cristiane B Dias, Vanda Jorgetti, Viktoria Woronik, Rosa M A Moysés
BACKGROUND: Fibroblast growth factor 23 (FGF23), a phosphate-regulating hormone is an established cardiovascular risk factor. Recently, FGF23 has been related to inflammation. Lupus is an inflammatory disease, and whether FGF23 is associated with Lupus nephritis (LN) activity is unknown. MATERIALS AND METHODS: We studied 15 pre-menopausal patients with recent LN diagnose (⩽2months) and compared them to 1:1 age-matched healthy control group. We measured serum levels of intact FGF23, interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and urinary levels of monocyte chemotactic protein (MCP1)...
January 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28060106/interleukin-6-and-interleukin-8-levels-correlate-with-the-severity-of-aplastic-anemia-in-children
#5
Vineeta Gupta, Sushil Kumar, Rimjhim Sonowal, Surya K Singh
AIM: The aim of this study was to evaluate the levels of interleukin (IL)-6 and IL-8 in patients with aplastic anemia and its correlation with severity of the disease. MATERIALS AND METHODS: IL-6 and IL-8 levels were measured in 40 patients with aplastic anemia in the age group of 4 to 14 years. A total of 40 healthy children served as controls. Quantitative estimation of IL-6 and IL-8 was performed using a solid-phase sandwich ELISA kit. Results were presented as IL-6 and IL-8 concentrations in pg/mL...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28053321/functionality-and-opposite-roles-of-two-interleukin-4-haplotypes-in-immune-cells
#6
G Anovazzi, M C Medeiros, S C Pigossi, L S Finoti, T M Souza Moreira, M P A Mayer, C F Zanelli, S R Valentini, C Rossa-Junior, R M Scarel-Caminaga
Cytokines expression can be influenced by polymorphisms in their respective coding genes. We associated the CTI/TTD haplotype (Hap-1) and TCI/CCI haplotype (Hap-2) in the IL4 gene formed by the -590, +33 and variable number of tandem repeat polymorphisms with the severity of chronic periodontitis in humans. The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate 13-acetate (PMA) with Ionomycin and IL-1β (as inflammatory stimuli) was evaluated. Gene expression (quantitative real-time PCR), profile of secreted cytokines (multiplex) and phenotypic polarization of T cells (flow cytometry) were the outcomes assessed...
January 5, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28051794/%C3%A2-effects-of-interleukin-4-and-interleukin-12b-gene-polymorphisms-on-hepatitis-b-virus-vaccination
#7
Eun Youn Roh, Eun Young Song, Jong Hyun Yoon, Sohee Oh, Ju Young Chang, Hyunwoong Park, Soo Hyun Seo, Sue Shin
 Approximately 10% of individuals do not respond to hepatitis B virus (HBV) vaccination, i.e. non-responders (NRs). We aimed to investigate the association of interleukin (IL)-4 and IL-12B gene polymorphisms with responsiveness to the HBV vaccine in Korean infants. Among 300 healthy infants (9-12 month), SNPs for the IL-4 gene (rs2243250, rs2070874, and rs2227284) and for the IL-12B gene (rs3213094 and rs17860508) were compared between subgroups in terms of the response to HBV vaccination. The percentages of NRs (< 10 mIU/mL), low-titer responders (LRs, 10-100 mIU/mL), and high-titer responders (HRs, ≥ 100 mIU/mL) were 20...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28049868/expression-of-epithelial-cell-derived-cytokine-genes-in-the-duodenal-and-colonic-mucosae-of-dogs-with-chronic-enteropathy
#8
Hironari Osada, Misato Ogawa, Ayana Hasegawa, Makoto Nagai, Junsuke Shirai, Kazuaki Sasaki, Minoru Shimoda, Hiroshi Itoh, Hirotaka Kondo, Keitaro Ohmori
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs...
December 29, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28045954/the-rs7044343-polymorphism-of-the-interleukin-33-gene-is-associated-with-decreased-risk-of-developing-premature-coronary-artery-disease-and-central-obesity-and-could-be-involved-in-regulating-the-production-of-il-33
#9
Javier Angeles-Martínez, Rosalinda Posadas-Sánchez, Luis Llorente, Edith Alvarez-León, Julian Ramírez-Bello, Teresa Villarreal-Molina, Guadalupe Lima, Guillermo Cardoso-Saldaña, José Manuel Rodríguez-Pérez, Nonanzit Pérez-Hernández, José Manuel Fragoso, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
AIM: The effect of interleukin 33 (IL-33) in the inflammatory process generates significant interest in the potential significance of IL-33 as a biomarker for coronary artery disease (CAD). Here, our objective was to analyze whether IL-33 gene polymorphisms are associated with premature CAD in a case-control association study. METHODS: Four IL-33 polymorphisms (rs7848215, rs16924144, rs16924159 and rs7044343) were genotyped by 5' exonuclease TaqMan assays in 1095 patients with premature CAD and 1118 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28043521/interleukin-10-gene-polymorphism-is-associated-with-multi-drug-resistant-tuberculosis-during-the-intensive-phase-of-standard-chemotherapy
#10
Butov Dmytro, Kuzhko Mykhailo, Butova Tetyana Kuzhko
OBJECTIVE/BACKGROUND: To study whether interleukin (IL)-10 gene polymorphism is associated with multi-drug resistant tuberculosis (MDR TB) during the intensive phase of standard chemotherapy. METHODS: The study comprised 170 individuals in Kharkiv region of Ukraine including 74 patients with pulmonary MDR TB (Group 1), 66 patients without MDR TB (Group 2), and 30 healthy donors (Group 3). Serum level of IL-10 was evaluated by enzyme-linked immunosorbent assay (pg/L)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28040120/a-mixture-of-st-john-s-wort-and-sea-buckthorn-oils-regresses-endometriotic-implants-and-affects-the-levels-of-inflammatory-mediators-in-peritoneal-fluid-of-the-rat-a-surgically-induced-endometriosis-model
#11
Mert İlhan, İpek Süntar, Mürşide Ayşe Demirel, Erdem Yeşilada, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVE: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oil) in the treatment of endometriosis. MATERIALS AND METHODS: The activity was assessed in surgically induced endometriosis in rats...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28036156/interleukin-4-cytokine-single-nucleotide-polymorphisms-in-kawasaki-disease-a-case-control-study-and-a-review-of-knowledge
#12
Raheleh Assari, Yahya Aghighi, Vahid Ziaee, Maryam Sadr, Arezou Rezaei, Farzaneh Rahmani, Zeinab Sadr, Seyed Reza Raeeskarami, Mohammad Hassan Moradinejad, Nima Rezaei
AIM: Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD. METHODS: Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28036117/gingivitis-and-lifestyle-influences-on-hs-crp-and-il6-in-adolescents
#13
Vinay Pitchika, Elisabeth Thiering, Isabel Metz, Katrin Rothmaier, Anja Willenberg, Reinhard Hickel, Marie Standl, Thomas Kocher, Joachim Heinrich, Jan Kühnisch
AIM: This cross-sectional study was repeated at two time points and investigated the influence of gingivitis, smoking and body mass index (BMI) on the systemic inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL6) in 10- and 15-year-olds. MATERIALS AND METHODS: The study sample of two birth cohorts, i.e., GINIplus and LISAplus, from the Munich centre consisted of 806 and 846 subjects who were evaluated at 10- and 15-year follow-ups, respectively...
December 30, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28025417/interleukin-33-in-allergic-diseases
#14
Ken Arae, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Susumu Nakae
No abstract text is available yet for this article.
2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28017959/interleukin-33-in-the-pathogenesis-of-liver-fibrosis-alarming-ilc2-and-hepatic-stellate-cells
#15
Ralf Weiskirchen, Frank Tacke
No abstract text is available yet for this article.
December 26, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28011865/leukotrienes-provide-an-nfat-dependent-signal-that-synergizes-with-il-33-to-activate-ilc2s
#16
Jakob von Moltke, Claire E O'Leary, Nora A Barrett, Yoshihide Kanaoka, K Frank Austen, Richard M Locksley
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung. In Th2 cells, T cell receptor (TCR) signaling activates the transcription factors nuclear factor of activated T cells (NFAT), nuclear factor κB (NF-κB), and activator protein 1 (AP-1) to induce type 2 cytokines. ILC2s lack a TCR and respond instead to locally produced cytokines such as IL-33. Although IL-33 induces AP-1 and NF-κB, NFAT signaling has not been described in ILC2s...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28010814/fire-service-instructor-s-undergarment-choice-to-reduce-interleukin-6-and-minimise-physiological-and-perceptual-strain
#17
Emily R Watkins, Alan J Richardson
Fire Service Instructors frequently experience high levels of physiological and perceptual strain during live fire exposures. Instructors are also at risk of cardiovascular illnesses, with cardiac death being the greatest cause of fire fighter death. Current practice for UK instructors is to select undergarment type based on personal preference, between a boiler suit (BOILER) and a wicking base layer (WBL). Research suggests that shorts and t-shirt (SHORTS) may also be a beneficial alternative undergarment choice...
January 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28000059/interleukin-33-expression-does-not-correlate-with-survival-of-gastric-cancer-patients
#18
Wenwei Hu, Xiaodong Li, Qing Li, Yan Tan, Bin Xu, Quanqin Xie, Xu Deng, Binfeng Lu, Jingting Jiang, Changping Wu
The aim of the study was to investigate IL-33 expression in gastric cancer (GC) and its association with the clinical characteristics and the prognosis. IL-33 protein in tumor and corresponding adjacent tissues were detected by immunohistochemistry in 179 GC patients and clinical features plus prognostic value were analyzed via Pearson's chi-square test and Kaplan-Meier test in Cox proportional hazards model, respectively. IL-33 protein levels were significantly lower in tumor tissues than adjacent tissues (29...
December 20, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28000005/comparison-of-cerebrospinal-fluid-profiles-in-alzheimer-s-disease-with-multiple-cerebral-microbleeds-and-cerebral-amyloid-angiopathy-related-inflammation
#19
Akio Kimura, Masao Takemura, Kuniaki Saito, Nobuaki Yoshikura, Yuichi Hayashi, Naoko Harada, Hiroshi Nishida, Hideto Nakajima, Takashi Inuzuka
Brain magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) sometimes reveals multiple cerebral microbleeds (CMBs) and confluent white matter hyperintensities (WMHs) similar to those observed in cerebral amyloid angiopathy-related inflammation (CAA-I). To determine whether there might be common pathophysiological mechanisms underlying the MRI findings of multiple CMBs and confluent WMHs, we investigated the cerebrospinal fluid (CSF) profiles of 38 AD, five amnestic mild cognitive impairment (MCI), and six CAA-I patients...
December 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27993220/intestinal-alkaline-phosphatase-decreases-intraperitoneal-adhesion-formation
#20
Sanjiv K Hyoju, Sara Morrison, Sarah Gul, Mohammad Hadi Gharedaghi, Mohamed Mussa, Mehran Najibi, Konstantinos P Economopoulos, Sulaiman R Hamarneh, Richard A Hodin
BACKGROUND: Damage to the peritoneum initiates an inflammatory response leading to the formation of adhesions, which subsequently cause significant morbidity in some patients. Intestinal alkaline phosphatase (IAP) is a gut enzyme capable of detoxifying various inflammatory mediators such as lipopolysaccharide, lipoteichoic acid, CpG DNA, and adenosine triphosphate. In this study, we aimed to examine the anti-inflammatory effects of IAP on postoperative adhesions in mice. METHODS: C57BL/6 mice were subjected to a midline laparotomy and then six musculoperitoneal buttons (MPBs) were created by pinching and ligating the peritoneum and underlying muscle...
February 2017: Journal of Surgical Research
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