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interleukin 33

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https://www.readbyqxmd.com/read/28919759/association-of-interleukin-33-gene-polymorphisms-with-susceptibility-to-late-onset-alzheimer-s-disease-a-meta-analysis
#1
Xin Zhong, Ming-Yan Liu, Miao He, Ke Du, Min-Jie Wei
The association between interleukin-33 (IL-33) gene polymorphisms and late onset Alzheimer's disease (LOAD) remains controversial in previous studies. Thus, a meta-analysis was conducted to assess the association between the IL-33 polymorphisms (rs11792633 and rs7044343) and LOAD susceptibility. Crude odds ratio (OR) and 95% confidence interval (CI) were used to investigate the relationship strength. Sensitivity analysis was performed, and publication bias was estimated by the Begg's and Egger's tests. Overall, six independent studies involving 2,589 patients and 8,414 control samples met our inclusion criteria and were included in this meta-analysis...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28914439/dampness-heat-accelerates-dmba-induced-mammary-tumors-in-rats
#2
Wei Dong, Xi-Lan Tang, Guang-Bin Shang, Guo-Liang Xu, Wei-Feng Zhu, Hong-Ning Liu
OBJECTIVE: To investigate the impact of dampness-heat (DH) on the development of mammary tumors in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rats. METHODS: Forty rats were randomly divided into 3 groups in a randomized block design, including the control group (n=13), DMBA group (n=14), and DMBA plus DH group (n=13). Rats in the DMBA group and DMBA plus DH group were intragastrically administrated with DMBA (100 mg/kg) for twice, once per week, while rats in the control group were treated with equivalent volumes of sesame oil...
September 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28912751/decreased-secondary-lesion-growth-and-attenuated-immune-response-after-traumatic-brain-injury-in-tlr2-4-mice
#3
Sandro M Krieg, Florian Voigt, Pascal Knuefermann, Carsten Jürgen Kirschning, Nikolaus Plesnila, Florian Ringel
Danger-associated molecular patterns are released by damaged cells and trigger neuroinflammation through activation of non-specific pattern recognition receptors, e.g., toll-like receptors (TLRs). Since the role of TLR2 and 4 after traumatic brain injury (TBI) is still unclear, we examined the outcome and the expression of pro-inflammatory mediators after experimental TBI in Tlr2/4(-/-) and wild-type (WT) mice. Tlr2/4(-/-) and WT mice were subjected to controlled cortical injury and contusion volume and brain edema formation were assessed 24 h thereafter...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28903122/impact-of-ixekizumab-treatment-on-depressive-symptoms-and-systemic-inflammation-in-patients-with-moderate-to-severe-psoriasis-an-integrated-analysis-of-three-phase-3-clinical-studies
#4
Christopher E M Griffiths, Maurizio Fava, Andrew H Miller, James Russell, Susan G Ball, Wen Xu, Nayan Acharya, Mark Hyman Rapaport
BACKGROUND: Depression is a common comorbidity in psoriasis, and both conditions are associated with systemic inflammation. The efficacy of ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, was evaluated in patients with moderate-to-severe plaque psoriasis (psoriasis) and depressive symptoms that were at least moderately severe. METHODS: Data were integrated from 3 randomized, double-blind, controlled phase 3 trials. At baseline and week 12, depressive symptoms and inflammation were assessed by the 16-item Quick Inventory of Depressive Symptomology - Self-Report (QIDS-SR16) and by a high-sensitivity assay of serum C-reactive protein (hsCRP), respectively...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28898270/cyclic-stretch-induced-il-33-production-through-hmgb1-tlr-4-signaling-pathway-in-murine-respiratory-epithelial-cells
#5
Jing Chang, Yuefeng Xia, Karla Wasserloos, Meihong Deng, Kory J Blose, David A Vorp, Heth R Turnquist, Timothy R Billiar, Bruce A Pitt, Ma-Zhong Zhang, Li-Ming Zhang
Interleukin 33 (IL-33), an inflammatory and mechanically responsive cytokine, is an important component of a TLR4-dependent innate immune process in mucosal epithelium. Although TLR4 also plays a role in sensing biomechanical stretch, a pathway of stretch-induced TLR4-dependent IL-33 biosynthesis has not been revealed. In the current study, we show that short term (6 h) cyclic stretch (CS) of cultured murine respiratory epithelial cells (MLE-12) increased intracellular IL-33 expression in a TLR4 dependent fashion...
2017: PloS One
https://www.readbyqxmd.com/read/28889151/hydrogen-water-ameliorates-the-severity-of-atopic-dermatitis-like-lesions-and-decreases-interleukin-1%C3%AE-interleukin-33-and-mast-cell-infiltration-in-nc-nga-mice
#6
Takuya Kajisa, Takuji Yamaguchi, Ailing Hu, Nobuhiro Suetake, Hiroyuki Kobayashi
OBJECTIVES: To examine the effect of hydrogen water (HW) on the severity of atopic dermatitis (AD) and elucidate the underlying pathophysiological mechanisms. METHODS: For this experimental study between March 2015 and December 2015, NC/Nga mice characterized by mild AD severity were given either HW (n=11) or purified water (PW) (n=9) ad libitum; specific-pathogen-free mice (n=9) were used as AD-free control. Atopic dermatitis severity score and transepidermal water loss (TEWL) were examined at baseline (0 week), and after 4 weeks of HW/PW treatment...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28881679/mir-487b-mitigates-chronic-heart-failure-through-inhibition-of-the-il-33-st2-signaling-pathway
#7
En-Wei Wang, Xu-Sheng Jia, Chang-Wu Ruan, Zhi-Ru Ge
We investigated the effects of microRNA-587b (miR-487b) in a rat model of chronic heart failure (CHF). Wistar rats were assigned to 10 groups (n=8 per group). Expression of interleukin-33 (IL-33), somatostatin 2 (ST2), IL-6, and TNF-α was higher in the CHF group than the control group. In the CHF, negative control (NC) for si-IL-33, NC for miR-487b mimic, NC for miR-487b inhibitor, and miR-487b inhibitor + si IL-33 groups, as compared to the blank and sham groups: steroid binding protein (SBP), D binding protein (DBP), left ventricular systolic pressure (LVSP), ± dp/dtmax, and superoxide dismutase (SOD) were all lower; myocardial fibrosis, MDA, left ventricular end-diastolic pressure (LVEDP), myocardial apoptosis rate, IL-6, and TNF-α were all higher; levels of IL-33 and ST2 mRNA and protein were higher; and levels of miR-487b were lower...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879509/il26-modulates-cytokine-response-and-anti-tnf-consumption-in-crohn-s-disease-patients-with-bacterial-dna
#8
Paula Piñero, Oriol Juanola, Ana Gutiérrez, Pedro Zapater, Paula Giménez, Anna Steinert, Laura Sempere, José M González-Navajas, Jan H Niess, Rubén Francés
Interleukin IL26 supports killing of microbes and the innate sensing of bacterial-derived DNA (bactDNA). We evaluated the relationship between IL26 serum levels and bactDNA translocation in Crohn's disease (CD). We ran a prospective study on CD patients in remission. IL26 common polymorphisms, serum cytokines and complement protein, amplified-bactDNA, and anti-TNF-α were evaluated. In vitro PBMC analysis was performed. Three hundred and thirteen patients were included (mean CDAI: 83.6 ± 32.8; mean fecal calprotectin: 55...
September 6, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28879051/targeting-danger-molecules-in-tendinopathy-the-hmgb1-tlr4-axis
#9
Moeed Akbar, Derek S Gilchrist, Susan M Kitson, Briana Nelis, Lindsay A N Crowe, Emma Garcia-Melchor, James H Reilly, Shauna C Kerr, George A C Murrell, Iain B McInnes, Neal L Millar
OBJECTIVES: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. METHODS: Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing 'early pathology') biopsies were collected from patients undergoing arthroscopic shoulder surgery...
2017: RMD Open
https://www.readbyqxmd.com/read/28878285/interleukin-33-promotes-inflammation-induced-lymphangiogenesis-via-st2-traf6-mediated-akt-enos-no-signalling-pathway
#10
Longhui Han, Minglian Zhang, Xu Liang, Xin Jia, Jinchen Jia, Miying Zhao, Yiming Fan
The interplay between inflammation and lymphangiogenesis is mediated by various cytokines. However, most of these molecules and their associated mechanism are yet to be defined. Here, we explored the role of IL-33 in modulating inflammation-induced lymphangiogenesis (ILA) and its underlying mechanisms using an ILA mouse model and a lymphatic endothelial cell (LEC) line. Our results show that IL-33 promoted the proliferation, migration and tube formation of LECs and ILA in vivo. The pro-lymphangiogenic activity of IL-33 was abolished by ST2 blockage...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878123/the-r213g-polymorphism-in-sod3-protects-against-allergic-airway-inflammation
#11
Rohit Gaurav, Jason T Varasteh, Michael R Weaver, Sean R Jacobson, Laura Hernandez-Lagunas, Qing Liu, Eva Nozik-Grayck, Hong Wei Chu, Rafeul Alam, Børge G Nordestgaard, Camilla J Kobylecki, Shoaib Afzal, Geoffrey L Chupp, Russell P Bowler
Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower airway hyperresponsiveness, inflammation, and mucus hypersecretion with decreased interleukin-33 (IL-33) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28877128/antioxidant-and-trace-element-supplementation-reduce-the-inflammatory-response-in-critically-ill-burn-patients
#12
Sarah Rehou, Shahriar Shahrokhi, Rimona Natanson, Mile Stanojcic, Marc G Jeschke
Oxidative stress after burn injury induces inflammatory and hypermetabolic responses associated with adverse outcomes. We propose that antioxidant and trace element supplementation may reduce oxidative stress and subsequently alleviate inflammation and hypermetabolism, thus improving clinical outcomes. We conducted a cohort study of adult patients with an acute burn injury admitted to our provincial burn center. Patients in the antioxidant group received an intravenous infusion of multivitamins and trace elements for the first 14 days after admission...
August 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28875265/possible-role-of-il-25-in-eosinophilic-lung-inflammation-in-patients-with-chronic-eosinophilic-pneumonia
#13
Shigeki Katoh, Masaki Ikeda, Nobuhiro Matsumoto, Hiroki Shimizu, Masaaki Abe, Yoshihiro Ohue, Keiji Mouri, Yoshihiro Kobashi, Masamitsu Nakazato, Mikio Oka
PURPOSE: Interleukin (IL)-25 and IL-33 induce IL-5 production by various types of cells, such as type 2 helper T (Th2) cells and type 2 innate lymphoid cells. The number of Th2 cells and concentration of IL-5 in the bronchoalveolar lavage fluid (BALF) are increased in patients with eosinophilic pneumonia (EP). To examine the contribution of IL-25 and IL-33 to eosinophilic inflammation of the lung in humans, we evaluated IL-5, IL-25 and IL-33 levels in the BALF of patients with EP. METHODS: IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis...
September 5, 2017: Lung
https://www.readbyqxmd.com/read/28871441/international-registry-on-the-use-of-the-cytosorb%C3%A2-adsorber-in-icu-patients-study-protocol-and-preliminary-results
#14
REVIEW
S Friesecke, K Träger, G A Schittek, Z Molnar, F Bach, K Kogelmann, R Bogdanski, A Weyland, A Nierhaus, F Nestler, D Olboeter, D Tomescu, D Jacob, H Haake, E Grigoryev, M Nitsch, A Baumann, M Quintel, M Schott, J T Kielstein, A Meier-Hellmann, F Born, U Schumacher, M Singer, J Kellum, F M Brunkhorst
INTRODUCTION: The aim of this clinical registry is to record the use of CytoSorb® adsorber device in critically ill patients under real-life conditions. METHODS: The registry records all relevant information in the course of product use, e. g., diagnosis, comorbidities, course of the condition, treatment, concomitant medication, clinical laboratory parameters, and outcome (ClinicalTrials.gov Identifier: NCT02312024). Primary endpoint is in-hospital mortality as compared to the mortality predicted by the APACHE II and SAPS II score, respectively...
September 4, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28870670/il-1-receptor-like-1-protects-against-alcoholic-liver-injury-by-limiting-nf-%C3%AE%C2%BAb-activation-in-hepatic-macrophages
#15
Meng Wang, Guannan Shen, Liangguo Xu, Xiaodong Liu, Jared M Brown, Dechun Feng, Ruth Ann Ross, Bin Gao, Suthat Liangpunsakul, Cynthia Ju
BACKGROUND & AIM: Alcohol consumption, through increasing intestinal permeability and causing hepatocytes damage, leads to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs). These molecules stimulate hepatic macrophages (MΦs) and activate NF-κB, resulting in inflammation and exacerbating alcoholic liver disease (ALD). However, much less is known about the mechanisms attenuating inflammation and preventing disease progression in the majority of the heavy drinkers...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28869447/high-concentration-of-mir-133-is-a-useful-marker-for-the-diagnosis-of-lymphoma-associated-hemophagocytic-syndrome
#16
Wuping Li, Yun Zhong, Yuerong Shuang, Hui Huang, Yan Huang, Li Yu, Xianbao Huang
BACKGROUND: Lymphoma associated hemophagocytic syndrome (LAHS) is one of the major adult secondary hemophagocytic lymphohistiocytosis (HLH). Early diagnosis and treatment contribute to improved outcome. No enlarge lymph nodes can often delay the diagnosis of underlying lymphoma. OBJECTIVE: To find out criteria distinguishing LAHS from HLH induced by benign diseases. METHODS: clinical characteristic and laboratory feature of 31 patients with HLH (10 benign disease-associated HLH and 21 LAHS) were analyzed retrospectively...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28868833/evaluation-of-interleukin-17-and-interleukin-23-in-pterygium-immunohistochemistry-study
#17
Kiew Ing Tiong, Aida Zairani Mohd Zahidin, S Kala A/P Sumugam, Joseph Uchang, Hazlita Dato' Mohd Isa
PURPOSE: To compare the interleukin-17 (IL-17) and interleukin-23 (IL-23) positive cell counts between pterygium and normal conjunctiva. DESIGN: A case-control study. METHODS: This study received ethical approval (NMRR Research ID 23957) and informed consent was obtained from all participants. It involved 20 participants with 20 samples of pterygium and 20 samples of normal conjunctiva that were obtained from the same eye of each participant...
September 4, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28866452/circulating-interleukin-6-levels-and-cardiovascular-and-all-cause-mortality-in-the-elderly-population-a-meta-analysis
#18
REVIEW
Honghong Li, Wenjuan Liu, Jiemei Xie
OBJECTIVE: Inflammatory markers may be associated with mortality in the elderly population. We conducted this meta-analysis to evaluate the association of elevated circulating interleukin-6 levels with cardiovascular or all-cause mortality in the general elderly population. METHODS: A comprehensive literature search was conducted through the Pubmed and Embase databases until April 2016. Prospective observational studies that investigated the association of circulating interleukin-6 levels with cardiovascular or all-cause mortality in the elderly general population (aged 60 years or more) were included...
August 18, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28866351/human-t-cell-leukemia-virus-type-i-tax-genotype-analysis-in-okinawa-the-southernmost-and-remotest-islands-of-japan-different-distributions-compared-with-mainland-japan-and-the-potential-value-for-the-prognosis-of-aggressive-adult-t-cell-leukemia-lymphoma
#19
Shugo Sakihama, Mineki Saito, Megumi Kuba-Miyara, Takeaki Tomoyose, Naoya Taira, Takashi Miyagi, Masaki Hayashi, Shigeko Kinjo, Sawako Nakachi, Iori Tedokon, Yukiko Nishi, Keita Tamaki, Kazuho Morichika, Jun-Nosuke Uchihara, Satoko Morishima, Ken-Nosuke Karube, Yuetsu Tanaka, Hiroaki Masuzaki, Takuya Fukushima
Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%)...
August 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28861078/increased-innate-lymphoid-cells-in-periodontal-tissue-of-the-murine-model-of-periodontitis-the-role-of-amp-activated-protein-kinase-and-relevance-for-the-human-condition
#20
Xu Qin, Md Nasrul Hoda, Cristiano Susin, Julie N Wheeler, Brendan Marshall, Libby Perry, Nancy Saad, Lin Yin, Ranya Elsayed, Mohammed Elsalanty, Rafik Abdelsayed, Jack C Yu, Krishnan M Dhandapani, Omid Akbari, Mahmood S Mozaffari, Babak Baban
Innate lymphoid cells (ILCs) are master regulators of immune and inflammatory responses, but their own regulatory mechanisms and functional roles of their subtypes (i.e., ILC1s-ILC3s) remain largely unresolved. Interestingly, AMP-activated protein kinase (AMPK), influences inflammatory responses, but its role in modulation of ILCs is not known. Periodontitis is a prevalent disorder with impairment of immune and inflammatory responses contributing importantly to its pathogenesis; however, neither the role of ILCs nor AMPK has been explored in this condition...
2017: Frontiers in Immunology
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