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https://www.readbyqxmd.com/read/29774168/evaluating-the-potential-for-maximized-t-cell-redistribution-entropy-to-improve-abscopal-responses-to-radiotherapy
#1
Rachel Walker, Jonathan D Schoenfeld, Shari Pilon-Thomas, Jan Poleszczuk, Heiko Enderling
The potential for local radiation therapy to elicit systemic (abscopal) anti-tumor immune responses has been receiving a significant amount of attention over the last decade. We recently developed a mathematical framework designed to simulate the systemic dissemination of activated T cells among multiple metastatic sites. This framework allowed the identification of non-intuitive patterns of T cell redistribution after localized therapy, and offered suggestions as to the optimal site to irradiate in order to increase the magnitude of an immune-mediated abscopal response...
September 2017: Convergent Science Physical Oncology
https://www.readbyqxmd.com/read/29770089/-salmonella-thompson-outbreak-associated-with-consumption-of-chicken-shawarma-and-the-usefulness-of-genome-sequencing-in-the-investigation
#2
C Gaulin, M Fiset, C Duchesne, D Ramsay, N Savard, A Urbanek, P A Pilon, V Usongo, S Bekal
Background: A sudden increase in Salmonella Thompson ( S . Thompson) cases distributed throughout three border regions in the province of Quebec in November 2016 triggered a provincial investigation to identify a common source of contamination and to put the appropriate control measures into place. Objective: To report on the outbreak and to describe the use of genomic sequencing to identify the salmonella serotype responsible. Methods: A descriptive survey of all reported cases of Salmonella serogroup C1 that had occurred between October 1, 2016 and February 15, 2017 was conducted...
September 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29763945/leishmanicidal-effects-of-piperlongumine-piplartine-and-its-putative-metabolites
#3
Fernanda de Lima Moreira, Thalita Bachelli Riul, Marcela de Lima Moreira, Alan Cesar Pilon, Marcelo Dias-Baruffi, Márcio S S Araújo, Norberto Peporine Lopes, Anderson R M de Oliveira
Piperlongumine is an amide alkaloid found in Piperaceae species that shows a broad spectrum of biological properties, including antitumor and antiparasitic activities. Herein, the leishmanicidal effect of piperlongumine and its derivatives produced by a biomimetic model using metalloporphyrins was investigated. The results showed that IC50 values of piperlongumine in promastigote forms of Leishmania infantum and Leishmania amazonensis were 7.9 and 3.3 µM, respectively. The IC50 value of piperlongumine in the intracellular amastigote form of L...
May 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29710457/anti-inflammatory-actions-of-herbal-medicines-in-a-model-of-chronic-obstructive-pulmonary-disease-induced-by-cigarette-smoke
#4
Lucas Possebon, Isabella de Souza Lima Lebron, Ligia Furlan da Silva, Julia Tagliaferri Paletta, Bruna Gabrieli Glad, Monielle Sant'Ana, Melina Mizusaki Iyomasa-Pilon, Helena Ribeiro Souza, Sara de Souza Costa, Giselda Pereira da Silva Rodriguesa, Maria de Lourdes Pereira, Andreia de Haro Moreno, Ana Paula Girol
The effects of four medicinal herbs (Arctium lappa, Plantago major, Mikania glomerata Spreng and Equisetum arvense) with anti-inflammatory properties were evaluated in a chronic obstructive pulmonary disease (COPD) model. Wistar rats were exposed to cigarette smoke during 8 weeks and one of the groups was orally given a solution containing 4% of each alcoholic herbal extracts during the exposure period. Control group was not exposed to smoke or treated. Histopathological, immunohistochemical and biochemical analyzes were performed...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706729/use-of-a-multivector-mandibular-distractor-for-treatment-of-pediatric-proximal-interphalangeal-joint-pilon-fractures-a-case-based-review
#5
Rachel Pedreira, Brian H Cho, Angela Geer, Ramon A DeJesus
Background: The difficulties in surgical treatment of pilon fractures of the finger include fragment reconstitution and posthealing stiffness. In adults, external fixation with traction and early active range of motion (AROM)/passive range of motion (PROM) during healing is considered necessary for avoiding joint stiffness and attaining realignment. The authors present a unique approach to pediatric pilon fractures that uses open reduction and multivector external fixation with delayed AROM/PROM...
April 2018: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29704528/plant-selenium-hyperaccumulation-ecological-effects-and-potential-implications-for-selenium-cycling-and-community-structure
#6
REVIEW
R Jason B Reynolds, Elizabeth A H Pilon-Smits
BACKGROUND: Selenium (Se) hyperaccumulation occurs in ~50 plant taxa native to seleniferous soils in Western USA. Hyperaccumulator tissue Se levels, 1000-15,000 mg/kg dry weight, are typically 100 times higher than surrounding vegetation. Relative to other species, hyperaccumulators also transform Se more into organic forms. SCOPE OF REVIEW: We review abiotic and biotic factors influencing soil Se distribution and bioavailability, soil being the source of the Se in hyperaccumulators...
April 25, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29694419/t-cell-mediated-immunity-after-combination-therapy-with-intralesional-pv-10-and-blockade-of-the-pd-1-pd-l1-pathway-in-a-murine-melanoma-model
#7
Hao Liu, Amy Weber, Jennifer Morse, Krithika Kodumudi, Ellen Scott, John Mullinax, Amod A Sarnaik, Shari Pilon-Thomas
Intralesional (IL) injection of Rose Bengal (PV-10) induces regression of injected and uninjected lesions in several murine tumor models. In this study, we investigated the anti-tumor response of combining IL PV-10 with blockade of the PD-1 / PD-L1 pathway and the role of immune cell populations in eliciting this response. To investigate the role of T cell subsets in mediating an immune response, B16 or M05 melanoma-bearing mice received combination therapy as well as CD8+, CD4+, or CD25+ depleting antibodies...
2018: PloS One
https://www.readbyqxmd.com/read/29687005/medium-long-term-radiographic-and-clinical-outcomes-after-surgical-treatment-of-intra-articular-tibial-pilon-fractures-by-three-different-techniques
#8
Carlo Biz, Andrea Angelini, Marco Zamperetti, Filippo Marzotto, Silvano Pierluigi Sperotto, Diego Carniel, Claudio Iacobellis, Pietro Ruggieri
Introduction: The goal of this retrospective, observational, case series study was to evaluate the medium-long-term clinical and radiographic results of the three most common surgical osteosynthesis techniques used for the treatment of articular tibial pilon fractures: ORIF, MIPO, and EF. Materials and Methods: A consecutive series of patients with articular pilon fractures who underwent surgery at our institution were enrolled in this study. Fractures were classified according to the Müller AO classification system...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#9
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29626605/mechanisms-of-selenium-hyperaccumulation-in-plants-a-survey-of-molecular-biochemical-and-ecological-cues
#10
REVIEW
Leonardo Warzea Lima, Elizabeth A H Pilon-Smits, Michela Schiavon
BACKGROUND: Selenium (Se) is a micronutrient required for many life forms, but toxic at higher concentration. Plants do not have a Se requirement, but can benefit from Se via enhanced antioxidant activity. Some plant species can accumulate Se to concentrations above 0.1% of dry weight and seem to possess mechanisms that distinguish Se from its analog sulfur (S). Research on these so-called Se hyperaccumulators aims to identify key genes for this remarkable trait and to understand ecological implications...
April 4, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29581985/the-feasibility-of-3d-printing-technology-on-the-treatment-of-pilon-fracture-and-its-effect-on-doctor-patient-communication
#11
Wenhao Zheng, Chunhui Chen, Chuanxu Zhang, Zhenyu Tao, Leyi Cai
Purpose: The aim of this study was to assess the feasibility and effectiveness of the three-dimensional (3D) printing technology in the treatment of Pilon fractures. Methods: 100 patients with Pilon fractures from March 2013 to December 2016 were enrolled in our study. They were divided randomly into 3D printing group ( n = 50) and conventional group ( n = 50). The 3D models were used to simulate the surgery and carry out the surgery according to plan in 3D printing group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29580523/postprandial-lipemia-and-fecal-fat-excretion-in-rats-is-affected-by-the-calcium-content-and-type-of-milk-fat-present-in-cheddar-type-cheeses
#12
Erik Ayala-Bribiesca, Sylvie L Turgeon, Geneviève Pilon, André Marette, Michel Britten
The aim of this study was to better understand the effect of calcium on the bioavailability of milk lipids from a cheese matrix using a rat model. Cheddar-type cheeses were manufactured with one of three types of anhydrous milk fat, control, olein or stearin, and salted with or without CaCl2 . The cheeses were fed to rats and postprandial lipemia was monitored. Feces were analyzed to quantify fatty acids excreted as calcium soaps. Higher calcium concentration in cheese caused a higher and faster triacylglycerol peak in blood, except for cheeses containing stearin...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29557199/quality-goal-attainment-and-maintenance-in-patients-with-type-ii-diabetes-mellitus-initiated-on-canagliflozin-or-a-glucagon-like-peptide-1-receptor-agonist-in-an-actual-practice-setting
#13
Carol H Wysham, Dominic Pilon, Mike Ingham, Marie-Hélène Lafeuille, Bruno Emond, Rhiannon Kamstra, Michael Pfeifer, Patrick Lefebvre
OBJECTIVE: To compare achievement of quality goals (HbA1c, weight loss/body mass index [BMI], systolic blood pressure [SBP]), including maintaining HbA1c, between patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin 300 mg (CANA) or a GLP-1 in an actual practice setting. METHODS: Adults with T2DM newly initiated on CANA or a GLP-1 were identified from the IQVIATM Real-World Data Electronic Medical Records-US database (2012Q2-2016Q1). To account for differences in baseline characteristics, inverse probability of treatment weighting was used...
March 27, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29552542/combination-of-ipilimumab-and-adoptive-cell-therapy-with-tumor-infiltrating-lymphocytes-for-patients-with-metastatic-melanoma
#14
John E Mullinax, MacLean Hall, Sangeetha Prabhakaran, Jeffrey Weber, Nikhil Khushalani, Zeynep Eroglu, Andrew S Brohl, Joseph Markowitz, Erica Royster, Allison Richards, Valerie Stark, Jonathan S Zager, Linda Kelley, Cheryl Cox, Vernon K Sondak, James J Mulé, Shari Pilon-Thomas, Amod A Sarnaik
Purpose: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic melanoma can be highly effective, but attrition due to progression before TIL administration (32% in prior institutional experience) remains a limitation. We hypothesized that combining ACT with cytotoxic T lymphocyte-associated antigen 4 blockade would decrease attrition and allow more patients to receive TIL. Experimental design: Thirteen patients with metastatic melanoma were enrolled...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29549660/is-the-sleeve-gastrectomy-always-a-better-procedure-five-year-results-from-a-retrospective-matched-case-control-study
#15
Antonio Vitiello, Vincenzo Pilone, Luca Ferraro, Pietro Forestieri
INTRODUCTION: Bariatric surgery is considered the most effective treatment for obesity. A recent worldwide survey demonstrated that Laparoscopic Sleeve Gastrectomy (LSG) is the most commonly performed bariatric procedure, while Laparoscopic Adjustable Gastric Banding (LAGB) has been almost abandoned. OBJECTIVES: The aim of this retrospective study was to compare 5-year results of LSG and LAGB at our Institution. MATERIALS AND METHODS: Prospective maintained database of our Institution was reviewed to find all patients who had undergone LSG between January 2009 and December 2011...
March 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29549139/neuropilin-1-expression-in-adipose-tissue-macrophages-protects-against-obesity-and-metabolic-syndrome
#16
Ariel Molly Wilson, Zhuo Shao, Vanessa Grenier, Gaëlle Mawambo, Jean-François Daudelin, Agnieszka Dejda, Frédérique Pilon, Natalija Popovic, Salix Boulet, Célia Parinot, Malika Oubaha, Nathalie Labrecque, Vincent de Guire, Mathieu Laplante, Guillaume Lettre, Florian Sennlaub, Jean-Sebastien Joyal, Michel Meunier, Przemyslaw Sapieha
Obesity gives rise to metabolic complications by mechanisms that are poorly understood. Although chronic inflammatory signaling in adipose tissue is typically associated with metabolic deficiencies linked to excessive weight gain, we identified a subset of neuropilin-1 (NRP1)-expressing myeloid cells that accumulate in adipose tissue and protect against obesity and metabolic syndrome. Ablation of NRP1 in macrophages compromised lipid uptake in these cells, which reduced substrates for fatty acid β-oxidation and shifted energy metabolism of these macrophages toward a more inflammatory glycolytic metabolism...
March 16, 2018: Science Immunology
https://www.readbyqxmd.com/read/29548763/comparison-of-atp-sulfurylase-2-from-selenium-hyperaccumulator-stanleya-pinnata-and-non-accumulator-stanleya-elata-reveals-differential-intracellular-localization-and-enzyme-activity-levels
#17
Ying Jiang, Michela Schiavon, Leonardo W Lima, Tripti, Rachel R Jones, Ali F El Mehdawi, Suzanne Royer, Zhaohai Zeng, Yuegao Hu, Elizabeth A H Pilon-Smits, Marinus Pilon
BACKGROUND: The plant Stanleya pinnata hyperaccumulates Se up to 0.5% of its dry weight in organic forms, whereas the closely related Stanleya elata does not hyperaccumulate Se. ATP sulfurylase (ATPS) can catalyze the formation of adenosine 5'-phosphoselenate (APSe) from ATP and selenate. We investigated the S. pinnata ATPS2 isoform (SpATPS2) to assess its possible role in Se hyperaccumulation. METHODS: ATPS expression and activity was compared in the two Stanleya species...
March 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29547044/hba1c-control-and-cost-effectiveness-in-patients-with-type-2-diabetes-mellitus-initiated-on-canagliflozin-or-a-glucagon-like-peptide-1-receptor-agonist-in-a-real-world-setting
#18
Carol H Wysham, Dominic Pilon, Mike Ingham, Marie-Hélène Lafeuille, Bruno Emond, Rhiannon Kamstra, Michael Pfeifer, Patrick Lefebvre
OBJECTIVE: To compare glycated hemoglobin (HbA1c) control and medication costs between patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin 300 mg (CANA) or a glucagon-like peptide 1 receptor agonist (GLP-1 RA) in a real-world setting. METHODS: Adults with T2DM newly initiated on CANA or a GLP-1 RA (index date) were identified from IQVIA™ Real-World Data Electronic Medical Records U.S. database (March 29, 2012-April 30, 2016). Inverse probability of treatment weighting accounted for differences in baseline characteristics...
March 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29508046/effects-of-two-nonpharmacological-treatments-on-the-sleep-quality-of-women-with-nocturia-a-randomized-controlled-clinical-trial
#19
Daniele Furtado-Albanezi, Soraia Pilon Jürgensen, Mariana Arias Avila, Grasiela Nascimento Correia, Patricia Driusso
INTRODUCTION AND HYPOTHESIS: The objective was to check the effects of two nonpharmacological treatments on the sleep quality of women with nocturia. METHODS: A randomized controlled clinical trial in which 40 women with nocturia were randomized into two groups; one was subjected to tibial nerve stimulation (GTNS) and the other received pelvic floor muscle training associated with behavioral therapy (GPFMT). Both groups were followed for 12 weeks, with one session/week; evaluated by the Pittsburgh Sleep Quality Index (PSQI), King's Heath Questionnaire (KHQ), and Epworth Sleepiness Scale (ESS)...
March 6, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29502279/a-4-week-preoperative-ketogenic-micronutrient-enriched-diet-is-effective-in-reducing-body-weight-left-hepatic-lobe-volume-and-micronutrient-deficiencies-in-patients-undergoing-bariatric-surgery-a-prospective-pilot-study
#20
Luigi Schiavo, Vincenzo Pilone, Gianluca Rossetti, Alfonso Barbarisi, Manuela Cesaretti, Antonio Iannelli
BACKGROUND: Before bariatric surgery (BS), moderate weight loss, left hepatic lobe volume reduction, and micronutrient deficiency (MD) identification and correction are desirable. OBJECTIVES: The objective of this study was to assess the safety and the effectiveness of a 4-week preoperative ketogenic micronutrient-enriched diet (KMED) in reducing body weight (BW), left hepatic lobe volume, and correcting MD in patients scheduled for BS. MATERIALS AND METHODS: In this prospective pilot study, a cohort of morbidly obese patients (n = 27, 17 females, 10 males) with a mean body mass index (BMI) of 45...
March 3, 2018: Obesity Surgery
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