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https://www.readbyqxmd.com/read/29126042/successful-treatment-of-infected-wound-dehiscence-after-minimally-invasive-locking-plate-osteosynthesis-of-tibial-pilon-and-calcaneal-fractures-by-plate-preservation-surgical-debridement-and-antibiotics
#1
Giandavide Ieropoli, Jorge Hugo Villafañe, Silvia Chiara Zompi, Umberto Morozzo, Riccardo D'Ambrosi, Federico Giuseppe Usuelli, Pedro Berjano
OBJECTIVE: The aim is to present a case series that illustrates possible benefits from combining minimally invasive plate osteosynthesis (MIPO), plastic surgery and antibiotic therapy, in order to treat and eradicate infection in patients with tibial pilon or calcaneal fractures. METHODS: Eleven consecutive patients with dehiscence of the surgical wound in outcomes MIPO using a Locking Compression Plate (LCP) for tibial pilon, or calcaneus fractures. The patients had developed a documented infection of the surgical wound...
October 23, 2017: Foot
https://www.readbyqxmd.com/read/29112114/role-of-scaffold-protein-proline-glutamic-acid-and-leucine-rich-protein-1-pelp1-in-the-modulation-of-adrenocortical-cancer-cell-growth
#2
Arianna De Luca, Paola Avena, Rosa Sirianni, Adele Chimento, Francesco Fallo, Catia Pilon, Ivan Casaburi, Vincenzo Pezzi
PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER's functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors. We previously demonstrated that, in adrenocortical carcinoma (ACC), ERα is upregulated and that estradiol activates the IGF-II/IGF1R signaling pathways defining the role of this functional cross-talk in H295R ACC cell proliferation. The aim of this study was to determine if PELP1 is expressed in ACC and may play a role in promoting the interaction between ERα and IGF1R allowing the activation of pathways important for ACC cell growth...
November 7, 2017: Cells
https://www.readbyqxmd.com/read/29107524/a-polyphenol-rich-cranberry-extract-reverses-insulin-resistance-and-hepatic-steatosis-independently-of-body-weight-loss
#3
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Vanessa Vilela, Stéphanie Dudonné, Geneviève Pilon, Maryse Fournier, Marc-André Lecours, Yves Desjardins, Denis Roy, Emile Levy, André Marette
OBJECTIVE: Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic and metabolic disorders in diet-induced obese (DIO) mice. However, whether such extracts can reverse obesity-linked metabolic alterations remains unknown. In the present study, we aimed to investigate the potential of a polyphenol-rich extract from cranberry (CE) to reverse obesity and associated metabolic disorders in DIO-mice. METHODS: Mice were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks...
October 18, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29103948/metabolic-stress-and-inflammatory-biomarker-responses-to-glucose-administration-in-fischer-344-rats-intraperitoneal-vs-oral-delivery
#4
Shinjini Pilon, Alison C Holloway, Errol M Thomson
INTRODUCTION: Metabolic effects of anthropogenic chemicals are a focus of environmental health research due to the significant public health implications. Conventional glucose tolerance tests (GTTs) do not generally examine multiple metabolic, inflammatory, and endocrine factors; however, responses to exogenous glucose can provide insight into mode-of-action and disease processes, and warrant consideration in developing models for toxicological assessment. METHODS: GTTs were conducted on male Fischer-344 rats to 1) assess the feasibility of measuring multiple analytes in small sample volumes; 2) monitor analyte response; and 3) determine whether route of glucose delivery (oral, OGTT vs...
November 2, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29097869/delayed-and-short-course-of-rapamycin-prevents-organ-rejection-after-allogeneic-liver-transplantation-in-rats
#5
Salim Hamdani, Allan Thiolat, Sina Naserian, Cynthia Grondin, Stéphane Moutereau, Anne Hulin, Julien Calderaro, Philippe Grimbert, José Laurent Cohen, Daniel Azoulay, Caroline Pilon
AIM: To test whether a delayed and short course of rapamycin would induce immunosuppressive effects following allogeneic orthotopic liver transplantation (OLT) in rats. METHODS: Allogeneic OLTs were performed using Dark Agouti livers transplanted into Lewis recipients, and syngeneic OLTs were performed using the Lewis rat strain. Rapamycin (1 mg/kg per day) was administered by gavage from day 4 to day 11 post-transplantation. Lymphocyte cellular compartments were analyzed by flow cytometry in draining lymph nodes, non-draining lymph nodes and the spleen at days 11 and 42 in rapamycin-treated rats, untreated control rats and syngeneic grafted rats...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29079366/quality-of-fracture-reduction-assessed-by-radiological-parameters-and-its-influence-on-functional-results-in-patients-with-pilon-fractures-a-prospective-multicentre-study
#6
Christoph Sommer, Sean E Nork, Matthew Graves, Michael Blauth, Mark Rudin, Karl Stoffel
INTRODUCTION: The management of pilon fractures remains a challenging issue. Due to the complexity of factors that influence the outcome, it has been questioned if anatomical reductions of articular fracture are relevant. The lack of a commonly accepted assessment of quality of fracture reduction compounded the uncertainty of the importance of anatomical reduction in pilon fracture. The current study aimed to define parameters that can better assess the reduction quality and to investigate the influence of reduction quality on functional outcomes...
October 20, 2017: Injury
https://www.readbyqxmd.com/read/29065036/is-it-safe-to-prep-the-external-fixator-in-situ-during-second-stage-pilon-surgical-treatment
#7
Paul J Nielsen, Leonid S Grossman, Justin C Siebler, Elizabeth R Lyden, Lori K Reed, Matthew A Mormino
OBJECTIVE: To evaluate the infection rate of our protocol of prepping the external fixator in situ during definitive second stage pilon fracture open reduction internal fixation. DESIGN: Retrospective clinical investigation. SETTING: Academic Level 1 Trauma Center. PATIENTS/PARTICIPANTS: Out of 229 patients with distal tibia fractures presenting to our institution from 1999-2014, 100 were treated in a two-stage fashion utilizing this protocol...
October 14, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29062214/analysis-of-the-variables-affecting-outcome-in-fractures-of-the-tibial-pilon-treated-by-open-reduction-and-internal-fixation
#8
Rafael Carbonell-Escobar, Juan C Rubio-Suarez, Aitor Ibarzabal-Gil, E Carlos Rodriguez-Merchan
OBJECTIVE: To assess variables that could be related to outcomes in fractures of the tibial pilon treated by open reduction and internal fixation (ORIF). DESIGN: Retrospective. SETTING: University Hospital. PATIENTS: A total 92 fractures of the tibial pilon treated by ORIF in a 5-year period. The minimum follow-up was 1 year (mean: 3.3 years; range: 1-5). INTERVENTION: ORIF with LCP-LISS plate...
October 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29058951/stability-of-the-syndesmosis-after-posterior-malleolar-fracture-fixation
#9
Matthew A Miller, Tyler C McDonald, Matthew L Graves, Clay A Spitler, George V Russell, LaRita C Jones, William Replogle, Jeremy A Wise, Josie Hydrick, Patrick F Bergin
BACKGROUND: We sought to define the rate of syndesmotic instability after anatomic reduction of the posterior malleolus when posterior stabilization of a trimalleolar or trimalleolar equivalent ankle fracture was chosen vs when a supine position and initially conservative management of the posterior elements was chosen. METHODS: The types of syndesmotic and posterior malleolar fixation used to treat adult patients with ankle fractures involving the posterior malleolus at our level I trauma center were retrospectively assessed (N = 198)...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29058239/low-purine-diet-is-more-effective-than-normal-purine-diet-in-reducing-the-risk-of-gouty-attacks-after-sleeve-gastrectomy-in-patients-suffering-of-gout-before-surgery-a-retrospective-study
#10
Luigi Schiavo, Guillaume Favrè, Vincenzo Pilone, Gianluca Rossetti, Gabriele De Sena, Antonio Iannelli, Alfonso Barbarisi
BACKGROUND: Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet. OBJECTIVES: The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty attacks and also whether a postoperative low-purine diet (LPD) may further reduce these attacks as compared to a normal-purine diet (NPD) in a series of patients suffering of gout before SG...
October 23, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29034966/influence-of-sulfate-supply-on-selenium-uptake-dynamics-and-expression-of-sulfate-selenate-transporters-in-selenium-hyperaccumulator-and-nonhyperaccumulator-brassicaceae
#11
Ali F El Mehdawi, Ying Jiang, Zack S Guignardi, Ahmad Esmat, Marinus Pilon, Elizabeth A H Pilon-Smits, Michela Schiavon
Stanleya pinnata not only hyperaccumulates selenium (Se) to 0.5% of its dry weight, but also exhibits higher tissue Se-to-sulfur (S) ratios than other species and its surroundings. To investigate the mechanisms underlying this Se enrichment, we compared S. pinnata with the nonhyperaccumulators S. elata and Brassica juncea for selenate uptake in long- (9 d) and short-term (1 h) assays, using different concentrations of selenate and competitor sulfate. Different sulfate pre-treatments (0, 0.5, 5 mM, 3 d) were also tested for effects on selenate uptake and sulfate transporters' expression...
October 16, 2017: New Phytologist
https://www.readbyqxmd.com/read/29026658/resolving-plasmid-structures-in-enterobacteriaceae-using-the-minion-nanopore-sequencer-assessment-of-minion-and-minion-illumina-hybrid-data-assembly-approaches
#12
Sophie George, Louise Pankhurst, Alasdair Hubbard, Antonia Votintseva, Nicole Stoesser, Anna E Sheppard, Amy Mathers, Rachel Norris, Indre Navickaite, Chloe Eaton, Zamin Iqbal, Derrick W Crook, Hang T T Phan
This study aimed to assess the feasibility of using the Oxford Nanopore Technologies (ONT) MinION long-read sequencer in reconstructing fully closed plasmid sequences from eight Enterobacteriaceae isolates of six different species with plasmid populations of varying complexity. Species represented were Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens and Klebsiella oxytoca, with plasmid populations ranging from 1-11 plasmids with sizes of 2-330 kb. Isolates were sequenced using Illumina (short-read) and ONT's MinION (long-read) platforms, and compared with fully resolved PacBio (long-read) sequence assemblies for the same isolates...
August 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29020280/campylobacter-fetus-cluster-among-men-who-have-sex-with-men-montreal-quebec-canada-2014-2016
#13
Xavier Marchand-Senécal, Sadjia Bekal, Pierre A Pilon, Jean-Loup Sylvestre, Christiane Gaudreau
From March 2014 to December 2016, a cluster of 13 cases of Campylobacter fetus intestinal and extraintestinal infections, including 2 patients with an aortic mycotic aneurysm, caused significant morbidity. The cluster likely resulted from sexual transmission between men having sex with men living in the greater Montreal area, Quebec, Canada.
July 10, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28988807/increased-risk-for-complications-following-removal-of-hardware-in-patients-with-liver-disease-pilon-or-pelvic-fractures-a-regression-analysis
#14
Bryan D Brown, Justin N Steinert, John W Stelzer, Richard S Yoon, Joshua R Langford, Kenneth J Koval
PURPOSE: Indications for removing orthopedic hardware on an elective basis varies widely. Although viewed as a relatively benign procedure, there is a lack of data regarding overall complication rates after fracture fixation. The purpose of this study is to determine the overall short-term complication rate for elective removal of orthopedic hardware after fracture fixation and to identify associated risk factors. MATERIALS AND METHODS: Adult patients indicated for elective hardware removal after fracture fixation between July 2012 and July 2016 were screened for inclusion...
October 3, 2017: Injury
https://www.readbyqxmd.com/read/28986074/finite-element-analysis-of-the-stability-of-ao-ota-43-c1-type-distal-tibial-fractures-treated-with-distal-tibia-medial-anatomic-plate-versus-anterolateral-anatomic-plate
#15
O Fuad Oken, A Ozgur Yildirim, Mehmet Asilturk
BACKGROUND: The treatment of a pilon fracture type is possible from a medial, an anterolateral approach or both medial and lateral. The aim of study was compare the stability of two different plate fixation of a tibia pilon AO-43C1 type fractures. MATERIAL AND METHODS: In this study, three-dimensional finite element stress analysis was applied using isotropic materials and static linear analysis. Loading of 400 N force was applied to the model of a patient fixed in a standing position...
October 3, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28975013/medication-adherence-treatment-patterns-and-dose-reduction-in-patients-with-metastatic-castration-resistant-prostate-cancer-receiving-abiraterone-acetate-or-enzalutamide
#16
Ajay S Behl, Lorie A Ellis, Dominic Pilon, Yongling Xiao, Patrick Lefebvre
BACKGROUND: The efficacy of and overall survival associated with metastatic castration-resistant prostate cancer (CRPC) treatments rely on patients' consistent adherence to the recommended dosage regimens. OBJECTIVES: To evaluate treatment patterns and patient adherence to abiraterone acetate or enzalutamide therapy in real-world practice, and to examine the factors that may be associated with medication dose reduction in patients with metastatic CRPC. METHODS: Retrospective analyses were conducted using the Truven Health MarketScan research databases among patients with metastatic CRPC who initiated treatment with abiraterone acetate or enzalutamide between October 1, 2012, and December 31, 2014 (index date)...
September 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28954524/impact-of-computed-tomography-on-operative-planning-for-ankle-fractures-involving-the-posterior-malleolus
#17
Steven Donohoe, R Kiran Alluri, J Ryan Hill, Mark Fleming, Eric Tan, Geoffrey Marecek
BACKGROUND: The purpose of this study was to (1) Determine the effect of computed tomography (CT) on identification of fractures involving the posterior malleolus, (2) determine its effect on operative indications, and (3) determine its effect on the overall operative plan. METHODS: Patients with ankle fractures involving the posterior malleolus were identified. Only injuries with complete preoperative plain radiographs and a CT scan were included. Spiral tibia fractures and pilon variants were excluded...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28919292/treatment-patterns-health-care-resource-utilization-and-spending-in-medicaid-beneficiaries-initiating-second-generation-long-acting-injectable-agents-versus-oral-atypical-antipsychotics
#18
Dominic Pilon, Neeta Tandon, Marie-Hélène Lafeuille, Rhiannon Kamstra, Bruno Emond, Patrick Lefebvre, Kruti Joshi
PURPOSE: Second-generation long-acting injectable therapies (SGA-LAIs) may reduce health care resource utilization (HRU) and health care costs compared with daily oral atypical antipsychotics (OAAs) in patients with schizophrenia due to reduced dosing frequency, delivery/monitoring by a health care provider, and improved adherence. The aim of the present study was to compare treatment patterns, HRU, and Medicaid spending in patients with schizophrenia initiated on SGA-LAIs (overall and according to agent) versus OAAs...
September 14, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28904724/treatment-of-high-energy-pilon-fractures-using-the-ilizarov-treatment
#19
Walid Osman, Zeineb Alaya, Hamdi Kaziz, Lassad Hassini, Meriem Braiki, Nader Naouar, Mohamed Laaziz Ben Ayeche
The management of high-energy pilon fractures is still controversial. Open reduction and internal fixation are often associated with serious complications. Various methods have been used to treat these injuries, with variable results. The aim of this retrospective study was to analyze the clinical and radiographic outcome of the ILIZAROV technique in patients with high-energy pilon fractures. Thirty cases of distal tibia epiphysis fractures (pilon fractures) were managed from 1999 to 2012. The study group included 5 cases of open fractures...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28898923/repurposing-a-novel-parathyroid-hormone-pth-analog-to-treat-hypoparathyroidism
#20
Venkatesh Krishnan, Yanfei L Ma, Catherine Z Chen, Natasha Thorne, Heather Bullock, Gregory Tawa, Christy Javella-Cauley, Shaoyou Chu, Weiming Li, Wayne Kohn, Mary D Adrian, Charles Benson, Lifei Liu, Masahiko Sato, Wei Zheng, Andre M Pilon, N Nora Yang, Henry U Bryant
BACKGROUND AND PURPOSE: Human parathyroid hormone (PTH) is critical for maintaining physiologic calcium homeostasis, and plays an important role in the formation and maintenance of bone. Full-length PTH and a truncated peptide form are approved for treatment of hypoparathyroidism and osteoporosis, respectively. Our initial goal was to develop an improved PTH therapy for osteoporosis, but clinical development was halted. The novel asset was then repurposed as an improved therapy for hypoparathyroidism...
September 12, 2017: British Journal of Pharmacology
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