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https://www.readbyqxmd.com/read/28526301/mfg-e8-reprogramming-of-macrophages-promotes-wound-healing-by-increased-bfgf-production-and-fibroblast-functions
#1
Patrick Laplante, Frédéric Brillant-Marquis, Marie-Joëlle Brissette, Benjamin Joannette-Pilon, Romain Cayrol, Victor Kokta, Jean-François Cailhier
Macrophages are essential for tissue repair. They have a crucial role in cutaneous wound healing, participating actively in the inflammation phase of the process. Unregulated macrophage activation may, however, represent a source of excessive inflammation leading to abnormal wound healing and hypertrophic scars. Our research group has demonstrated that apoptotic endothelial and epithelial cells secrete Milk Fat Globule Epidermal Growth Factor-8 (MFG-E8), which has the ability to reprogram macrophages from a M1 (pro-inflammatory) to a M2 (anti-inflammatory pro-repair) phenotype...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28520582/intramedullary-nailing-for-pilon-nonunions
#2
Justin M Haller, Michael Githens, Robert Dunbar
No abstract text is available yet for this article.
May 16, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28504809/effect-of-lymphedema-treatment-for-management-of-acute-pilon-fractures
#3
John M Whatley, James A Lalonde, Craig C Greene, Kevin B Riche, Danielle M Tatum
Pilon fractures are high-energy injuries that often result in considerable edema and compromise of the soft tissue envelope of the ankle. These injuries are typically staged with an external fixator until the soft tissue is amenable for definitive fixation. This study was conducted to determine the effects of lymphedema treatment for the management of pilon fractures. Patients who underwent open reduction and internal fixation of pilon fractures between 2007 and 2014 at the authors' level II trauma center were identified by Current Procedural Terminology codes indicative of placement of an external fixator (20690) and open reduction and internal fixation of a pilon fracture (27826, 27827, or 27828)...
May 15, 2017: Orthopedics
https://www.readbyqxmd.com/read/28476393/is-it-worth-discriminating-against-patients-who-smoke-a-systematic-literature-review-on-the-effects-of-tobacco-use-in-foot-and-ankle-surgery
#4
REVIEW
Jason H Kim, Sandeep Patel
Although numerous studies have linked smoking with lower extremity wound and bone healing complications, a comprehensive study on the effects of smoking in foot and ankle surgery has not yet been reported. The purpose of the present study was to report the results of our systemic literature review, identifying the effects of tobacco use on common foot and ankle procedures. The systematic literature review was performed according to guidelines set by the PRIMSA statement (Preferred Reporting Items for Systematic Review and Meta-Analyses)...
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28475103/core-defect-reduction-in-zno-nanorods-by-cobalt-incorporation
#5
Adrien Savoyant, Hatim Alnoor, Olivier Pilone, Omer Nur, Magnus Willander
Zinc oxide (ZnO) nanorods grown by the low-temperature (90°C) aqueous chemical method with different cobalt concentration within the synthesis solution (from 0% to 15%), are studied by electron paramagnetic resonance (EPR), just above the liquid helium temperature. The anisotropic spectra of substitutional Co2+ reveal a high crystalline quality and orientation of the NRs, as well as the probable presence of a secondary disordered phase of ZnO:Co. The analysis of the EPR spectra indicates that the disappearance of the paramagnetic native core-defect (CD) at g~1...
May 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28461913/high-energy-pilon-fractures-management-state-of-the-art
#6
REVIEW
Jordi Tomás-Hernández
High-energy pilon fractures are challenging injuries. Multiple options are described for the definitive surgical management of these fractures, but there is no level I evidence for optimal management. The current management and recommendations for treatment will be reviewed in this article.Anatomical reduction of the fracture, restoration of joint congruence and reconstruction of the posterior column with a correct limb axis minimising the soft-tissue insult are the key points to a good outcome when treating pilon fractures...
October 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28458472/plating-of-pilon-fractures-based-on-the-orientation-of-the-fibular-shaft-component-a-biomechanical-study-evaluating-plate-stiffness-in-a-cadaveric-fracture-model
#7
Gennadiy A Busel, J Tracy Watson
OBJECTIVES: To evaluate mechanically superior method of pilon fracture fixation by comparing axial stiffness between anterolateral and medial tibial locking plates in a cadaveric fracture model. METHODS: Eight matched pairs of fresh frozen cadaver specimens (lower limb after through-knee disarticulation) were used to eliminate confounder of bone quality. Simulated pilon fractures were created so that each pair represented either varus or valgus fracture pattern (AO 43-A2) with associated fibular fractures (transverse or comminuted)...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28405879/histopathological-and-genetic-characterization-of-aldosterone-producing-adenomas-with-concurrent-subclinical-cortisol-hypersecretion-a-case-series
#8
Francesco Fallo, Isabella Castellano, Celso E Gomez-Sanchez, Yara Rhayem, Catia Pilon, Valentina Vicennati, Donatella Santini, Valeria Maffeis, Ambrogio Fassina, Paolo Mulatero, Felix Beuschlein, Martin Reincke
PURPOSE: Aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion are reported in an increasing number of patients. Five aldosterone-producing adenomas from patients with primary aldosteronism and subclinical hypercortisolism were examined. THE AIMS OF OUR STUDY WERE: (1) to analyze pathological features and immunohistochemical expression of CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) in these tumors; (2) to investigate somatic mutations involved in adrenal steroid hypersecretion and/or tumor growth...
April 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28400871/results-of-arthroscopic-ankle-arthrodesis-with-fixation-using-two-parallel-headless-compression-screws-in-a-heterogenic-group-of-patients
#9
Lukas Kolodziej, Boguslaw Sadlik, Sebastian Sokolowski, Andrzej Bohatyrewicz
BACKGROUND: As orthopedic surgeons become skilled in ankle arthroscopy technique and evidence -based data is supporting its use, arthroscopic ankle arthrodesis (AAA) will likely continue to increase, but stabilization methods have not been described clearly. We present a technique for two parallel 7.3-mm headless compression screws fixation (HCSs) for AAA in cases of ankle arthritis with different etiology, both traumatic and non-traumatic, including neuromuscular and inflammatory patients...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28386478/changes-in-the-microrna-profile-observed-in-the-subcutaneous-adipose-tissue-of-obese-patients-after-laparoscopic-adjustable-gastric-banding
#10
Carmela Nardelli, Laura Iaffaldano, Vincenzo Pilone, Giuseppe Labruna, Maddalena Ferrigno, Nicola Carlomagno, Concetta Anna Dodaro, Pietro Forestieri, Pasqualina Buono, Francesco Salvatore, Lucia Sacchetti
Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28380552/effects-of-grazing-management-and-buffer-strips-on-metal-runoff-from-pastures-fertilized-with-poultry-litter
#11
C Pilon, P A Moore, D H Pote, J W Martin, P B DeLaune
Metal runoff from fields fertilized with poultry litter may pose a threat to aquatic systems. Buffer strips located adjacent to fields may reduce nutrients and solids in runoff. However, scant information exists on the long-term effects of buffer strips combined with grazing management on metal runoff from pastures. The objective of this study was to assess the 12-yr impact of grazing management and buffer strips on metal runoff from pastures receiving poultry litter. The research was conducted using 15 watersheds (25 m wide and 57 m long) with five treatments: hayed (H), continuously grazed (CG), rotationally grazed (R), rotationally grazed with a buffer strip (RB), and rotationally grazed with a fenced riparian buffer strip (RBR)...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28380550/long-term-effects-of-grazing-management-and-buffer-strips-on-soil-erosion-from-pastures
#12
C Pilon, P A Moore, D H Pote, J H Pennington, J W Martin, D K Brauer, R L Raper, S M Dabney, J Lee
High grazing pressure can lead to soil erosion in pastures, causing increased sediment delivery to waterways. The objectives of this research were to evaluate the impact of grazing management and buffer strips on soil erosion by assessing soil physical properties, hydrology, and sediment loads from pastures fertilized with broiler litter. Field studies were conducted for 12 yr on 15 small watersheds. Five management strategies were evaluated: hayed (H), continuously grazed (CG), rotationally grazed (R), rotationally grazed with a buffer strip (RB), and rotationally grazed with a fenced riparian buffer (RBR)...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28365167/outcomes-of-the-ilizarov-frame-use-in-elderly-patients
#13
Efthymios Iliopoulos, Natasha Morrissey, Seok Cho, Arshad Khaleel
AIM: The use of circular frame is widely accepted. This is an outcome review on use of circular Ilizarov frame in elderly patients. MATERIALS & METHODS: Data from all patients treated with an Ilizarov circular frame between January 2002 and December 2014, who were 65 years of age or over at surgery was collected. Seventy Ilizarov circular frames were applied during this period in our unit at a mean age of 71.2 years. Clinical, radiological and quality of life questionnaire (SF-12) data were gathered...
March 30, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28365069/quality-of-life-and-prognostic-factors-after-intra-articular-tibial-pilon-fracture
#14
Jorge De-Las-Heras-Romero, Ana M Lledo-Alvarez, Alejandro Lizaur-Utrilla, Fernando A Lopez-Prats
BACKGROUND: Intra-articular tibial plafond fractures are a challenge for the surgeon with generally poor functional outcomes. The purpose was to assess the impact of this injury on patient quality of life (QOL), as well as analyzed the predictor factors. METHODS: Retrospective study of 47 patients with mean age of 44.4 (range 18-79) years. Patients were also invited for new clinical and radiological assessments. QOL was evaluated by the Short Form-36 questionnaire and compared to the standard in the age-matched general population...
March 22, 2017: Injury
https://www.readbyqxmd.com/read/28359592/clinical-efficacy-and-safety-of-limited-internal-fixation-combined-with-external-fixation-for-pilon-fracture-a-systematic-review-and-meta-analysis
#15
Shao-Bo Zhang, Yi-Bao Zhang, Sheng-Hong Wang, Hua Zhang, Peng Liu, Wei Zhang, Jing-Lin Ma, Jing Wang
PURPOSE: To compare the clinical efficacy and complications of limited internal fixation combined with external fixation (LIFEF) and open reduction and internal fixation (ORIF) in the treatment of Pilon fracture. METHODS: We searched databases including Pubmed, Embase, Web of science, Cochrane Library and China Biology Medicine disc for the studies comparing clinical efficacy and complications of LIFEF and ORIF in the treatment of Pilon fracture. The clinical efficacy was evaluated by the rate of nonunion, malunion/delayed union and the excellent/good rate assessed by Mazur ankle score...
April 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28356723/treatment-patterns-in-medicaid-patients-with-schizophrenia-initiated-on-a-first-or-second-generation-long-acting-injectable-versus-oral-antipsychotic
#16
Dominic Pilon, Kruti Joshi, Neeta Tandon, Marie-Hélène Lafeuille, Rhiannon L Kamstra, Bruno Emond, Patrick Lefebvre
BACKGROUND: Poor antipsychotic (AP) adherence is a key issue in patients with schizophrenia. First-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) long-acting injectable therapies (LAI) may improve adherence compared to oral antipsychotics (OAP). The objective of the study was to compare treatment adherence and persistence in Medicaid patients with schizophrenia initiated on first-generation long-acting injectable therapies (FGA-LAI) or second-generation long-acting injectable therapies (SGA-LAI) versus OAP...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28352645/toward-a-better-understanding-of-enteric-gliogenesis
#17
COMMENT
Baptiste Charrier, Nicolas Pilon
Most of gastrointestinal functions are controlled by the enteric nervous system (ENS), which contains a vast diversity of neurons and glial cells. In accordance with its key role, defective ENS formation is the cause of several diseases that affect quality of life and can even be life-threatening. Treatment of these diseases would greatly benefit from a better understanding of the molecular mechanisms underlying ENS formation. In this regard, although several important discoveries have been made over the years, how the full spectrum of enteric neuronal and glial cell subtypes is generated from neural crest cells during development still remains enigmatic...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28348554/barriers-to-radiation-induced-in-situ-tumor-vaccination
#18
REVIEW
Erik Wennerberg, Claire Lhuillier, Claire Vanpouille-Box, Karsten A Pilones, Elena García-Martínez, Nils-Petter Rudqvist, Silvia C Formenti, Sandra Demaria
The immunostimulatory properties of radiation therapy (RT) have recently generated widespread interest due to preclinical and clinical evidence that tumor-localized RT can sometimes induce antitumor immune responses mediating regression of non-irradiated metastases (abscopal effect). The ability of RT to activate antitumor T cells explains the synergy of RT with immune checkpoint inhibitors, which has been well documented in mouse tumor models and is supported by observations of more frequent abscopal responses in patients refractory to immunotherapy who receive RT during immunotherapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28337901/cardiopathy-and-osteoporosis-the-epidemiology-in-a-region-of-italy
#19
A Notarnicola, G Maccagnano, L Moretti, S Tafuri, B Moretti
Cardiopathies and osteoporosis are inter-related due to pathogenetic, hormonal, genetic features as well as an increased risk of fragility. An important feature is attributed to the process of atherosclerosis, which is responsible for an osteopenia effect and degeneration of vascular walls. To date the study populations have been limited. To verify the incidence of cardio-vascular disease in a larger osteoporotic population, we designed a retrospective clinical study analyzing the “Hospital Discharge Data” (HDD) in Apulia between 2006 and 2010...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28336099/direct-fixation-of-fractures-of-the-posterior-pilon-via-a-posteromedial-approach
#20
Harm Hoekstra, Wouter Rosseels, Stefan Rammelt, Stefaan Nijs
The treatment of fractures of the posterior pilon is a timely issue. Restoration of the integrity of the incisura fibularis and subsequent anatomic reduction of the fibula are essential for reconstruction of the ankle mortise after trauma, and syndesmotic stability. Inappropriate treatment ultimately will lead to a poor functional outcome and quality of life. Open reduction and direct internal fixation through a posterolateral or posteromedial approach are increasingly preferred over indirect reduction and anteroposterior screw fixation...
March 19, 2017: Injury
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