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https://www.readbyqxmd.com/read/27913982/pharmacological-management-of-allergic-rhinitis-in-the-elderly
#1
REVIEW
Andrzej Bozek
Recent studies suggest that allergic rhinitis is highly prevalent in the elderly population, but is underdiagnosed and undertreated. This review article briefly introduces allergic rhinitis in the elderly (epidemiology and pathophysiology) and identifies the main goals of treatment in these patients with respect to age-related physiological factors, comorbid conditions and polypharmacy. The primary focus of the article is a narrative review of the literature concerning the different types of treatment options in elderly patients aged 60+ years (pharmacological therapy and allergen-specific immunotherapy)...
December 3, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27913580/responding-to-challenges-for-people-with-psychotic-illness-updated-evidence-from-the-survey-of-high-impact-psychosis
#2
REVIEW
Vera A Morgan, Anna Waterreus, Vaughan Carr, David Castle, Martin Cohen, Carol Harvey, Cherrie Galletly, Andrew Mackinnon, Patrick McGorry, John J McGrath, Amanda L Neil, Suzy Saw, Johanna C Badcock, Debra L Foley, Geoff Waghorn, Sarah Coker, Assen Jablensky
OBJECTIVE: The objective is to summarise recent findings from the 2010 Australian Survey of High Impact Psychosis (SHIP) and examine their implications for future policy and planning to improve mental health, physical health and other circumstances of people with a psychotic disorder. METHODS: Survey of High Impact Psychosis collected nationally representative data on 1825 people with psychotic illness. Over 60 papers have been published covering key challenges reported by participants: financial problems, loneliness and social isolation, unemployment, poor physical health, uncontrolled symptoms of mental illness, and lack of stable, suitable housing...
December 1, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27913422/factor-xi-deficiency-enhances-the-pulmonary-allergic-response-to-house-dust-mite-in-mice-independent-of-factor-xii
#3
Ingrid Stroo, Jack Yang, Johannes Daan de Boer, Joris J T H Roelofs, Cornelis van 't Veer, Francis J Castellino, Sacha Zeerleder, Tom van der Poll
Asthma is associated with activation of coagulation in the airways. The coagulation system can be initiated via the extrinsic tissue factor dependent pathway or via the intrinsic pathway, in which the central player factor XI (FXI) can be either activated via active factor XII (FXIIa) or via thrombin. We aimed to determine the role of the intrinsic coagulation system, and its possible route of activation, in allergic lung inflammation induced by the clinically relevant human allergen house dust mite (HDM). Wild-type (WT), FXI knockout (KO) and FXII KO mice were subjected to repeated exposure to HDM via the airways, and inflammatory responses were compared...
December 2, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27913044/clinical-validation-of-the-50-gene-ampliseq-cancer-panel-v2-for-use-on-a-next-generation-sequencing-platform-using-formalin-fixed-paraffin-embedded-and-fine-needle-aspiration-tumour-specimens
#4
Vivek Rathi, Gavin Wright, Diana Constantin, Siok Chang, Huong Pham, Kerryn Jones, Atha Palios, Sue-Anne Mclachlan, Matthew Conron, Penny McKelvie, Richard Williams
The advent of massively parallel sequencing has caused a paradigm shift in the ways cancer is treated, as personalised therapy becomes a reality. More and more laboratories are looking to introduce next generation sequencing (NGS) as a tool for mutational analysis, as this technology has many advantages compared to conventional platforms like Sanger sequencing. In Australia all massively parallel sequencing platforms are still considered in-house in vitro diagnostic tools by the National Association of Testing Authorities (NATA) and a comprehensive analytical validation of all assays, and not just mere verification, is a strict requirement before accreditation can be granted for clinical testing on these platforms...
November 29, 2016: Pathology
https://www.readbyqxmd.com/read/27912857/homelessness-and-aging-the-contradictory-ordering-of-house-and-home
#5
Amanda Grenier, Rachel Barken, Colleen McGrath
The concepts of 'house' and 'home' are compelling and contradictory. They are compelling because they elicit the desired sentiments of permanence, feeling 'at home', and maintaining continuity in one's life. At the same time, they can be experienced as contradictory where organizational practices and the socio-cultural imperatives of individual responsibility, cost containment, and rationed services are concerned. Where 'house' tends to evoke a sense of permanent stability, 'home' is regarded as the ideal living environment and site of care for older people...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27912850/oscillating-in-and-out-of-place-experiences-of-older-adults-residing-in-homeless-shelters-in-montreal-quebec
#6
Victoria F Burns
Aging in place is desirable from the perspective of older adults and policy makers alike. However, the meaning of 'place' for adults experiencing homelessness has been largely overlooked. Addressing this gap, this constructivist grounded theory study discusses the meaning of place for 15 older adults residing in emergency homeless shelters in Montreal, Quebec. Findings revealed that four interrelated dimensions of place-that is, control, comfort, privacy, and security were instrumental in supporting participants' ability to feel in place across housed-homeless trajectories...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27912748/challenges-to-access-and-provision-of-palliative-care-for-people-who-are-homeless-a-systematic-review-of-qualitative-research
#7
Briony F Hudson, Kate Flemming, Caroline Shulman, Bridget Candy
BACKGROUND: People who are homeless or vulnerably housed are a marginalized group who often experience high rates of morbidity and die young as a result of complex problems. Access to health care and support can be challenging, with access to palliative care even more so. This review presents a synthesis of published qualitative research exploring from the perspective of homeless people and those working to support them, current challenges to palliative care access and provision, in addition to suggestions for what may improve palliative care for this population...
December 3, 2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27911984/home-visitation-programs-an-untapped-opportunity-for-the-delivery-of-early-childhood-obesity-prevention
#8
S-J Salvy, K de la Haye, T Galama, M I Goran
BACKGROUND: Extant obesity efforts have had limited impact among low-income underserved children, in part because of limitations inherent to existing programs: (i) short duration and low intensity; (ii) late timing of implementation, when children are already overweight or obese; (iii) intervention delivery limiting their accessibility and sustainability; and (iv) failure to address barriers such as a lack of culturally competent services, poverty and housing instability, which interfere with healthy lifestyle changes...
December 2, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27911387/use-of-a-filter-cartridge-for-filtration-of-water-samples-and-extraction-of-environmental-dna
#9
Masaki Miya, Toshifumi Minamoto, Hiroki Yamanaka, Shin-Ichiro Oka, Keiichi Sato, Satoshi Yamamoto, Tetsuya Sado, Hideyuki Doi
Recent studies demonstrated the use of environmental DNA (eDNA) from fishes to be appropriate as a non-invasive monitoring tool. Most of these studies employed disk fiber filters to collect eDNA from water samples, although a number of microbial studies in aquatic environments have employed filter cartridges, because the cartridge has the advantage of accommodating large water volumes and of overall ease of use. Here we provide a protocol for filtration of water samples using the filter cartridge and extraction of eDNA from the filter without having to cut open the housing...
November 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911240/an-improvement-program-as-a-way-to-intensify-inter-professional-collaboration-in-the-community-for-people-with-mental-disabilities-a-follow-up
#10
Ann-Christin Janlöv, Ingrid Ainalem, Ann-Christine Andersson, Agneta Berg
The aim of the study was to follow up inter-professional experiences of improvement work one year after a completed CII improvement program aiming at improve health care and social services for people with mental disabilities living in ordinary housing. This study was performed with a qualitative descriptive approach which employed six focus group interviews followed by a thematic analysis. The results revealed four themes; Self-awareness and insights; Behavior and actions in daily practice; Organizational cultures and subcultures; and Organizational practices, using Ken Wilbers' integral theory of four quadrants of realities as a holistic frame in the discussion...
December 2, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27911236/patient-versus-physician-reported-facial-disability-in-vestibular-schwannoma-an-international-cross-sectional-study
#11
Øystein Vesterli Tveiten, Matthew L Carlson, Frederik Goplen, Erling Myrseth, Colin L W Driscoll, Rupavathana Mahesparan, Michael J Link, Morten Lund-Johansen
OBJECTIVE Patient-reported outcomes are increasingly used in studies of vestibular schwannoma (VS); however, few studies have examined self-evaluated facial nerve function and its relation to physician-reported outcomes. The primary objective of this study was to compare patient self-evaluations of facial disability with physician-evaluated facial nerve status and with self-evaluations of a healthy control group. The second objective was to provide insight into the controversial subject of the optimal initial management of small- and medium-sized VSs; consequently, the authors compared patient-reported facial nerve disability following treatment via observation (OBS), Gamma Knife surgery (GKS), or microsurgery (MS)...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27910990/a-ph-responsive-sequential-disassembly-nanohybrid-for-mitochondrial-targeting
#12
Lijia Li, Wei Sun, Lian Li, Yuanyuan Liu, Lei Wu, Fengling Wang, Zhou Zhou, Zhirong Zhang, Yuan Huang
Cationic materials have been reported as promising tools for targeting to mitochondria which are the "power houses" and "metabolic garbage keepers" of cells. However, their positive nature also restricts their in vivo application due to the quick clearance. Herein, we fabricated a nanohybrid consisting of the pH-responsive N-(2-hydroxypropyl)methacrylamide (HPMA) co-polymer (R-P) shells and positive mesoporous silica nanoparticle cores via electrostatic interaction. The anticancer drug, docetaxel (DTX), was encapsulated in the positive MSN cores (MSN-DTX)...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27910691/compact-ecei-system-with-in-vessel-reflective-optics-for-west
#13
Y B Nam, H K Park, W Lee, G S Yun, M Kim, R Sabot, D Elbeze, P Lotte, J Shen
An electron cyclotron emission imaging (ECEI) diagnostic system for WEST (W Environment for Steady state Tokamak) is under development to study the MHD instabilities affected by tungsten impurities. The system will provide 2-D Te fluctuation images (width × height = ∼18 cm × ∼ 34 cm at low field side and ∼13 cm × ∼ 39 cm at high field side) from a poloidal cross section with high spatial (≤1.7 cm) and temporal (≤2 μs) resolutions. While the key concept and electronic structure are similar to that of prior ECEI systems on other tokamak devices such as KSTAR, DIII-D, or ASDEX-U, part of the imaging optics have to be placed inside the vacuum vessel in order to resolve issues on limited installation space and longer beam path to the detector position...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910582/experimentally-determining-the-relative-efficiency-of-spherically-bent-germanium-and-quartz-crystals
#14
G V Brown, P Beiersdorfer, N Hell, E Magee
We have used the EBIT-I electron beam ion trap at the Lawrence Livermore National Laboratory and a duplicate Orion High Resolution X-ray Spectrometer (OHREX) to measure the relative efficiency of a spherically bent quartz (101̄1) crystal (2d = 6.687 Å) and a spherically bent germanium (111) crystal (2d = 6.532 Å). L-shell X-ray photons from highly charged molybdenum ions generated in EBIT-I were simultaneously focussed and Bragg reflected by each crystal, both housed in a single spectrometer, onto a single CCD X-ray detector...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910419/design-and-fabrication-of-a-window-for-the-gas-cherenkov-detector-3
#15
V E Fatherley, D A Bingham, M D Cartelli, R A DiDomizio, J R Griego, H W Herrmann, F E Lopez, J A Oertel, M J Pollack
The gas Cherenkov detector 3 was designed at Los Alamos National Laboratory for use in inertial confinement fusion experiments at both the Omega Laser Facility and the National Ignition Facility. This instrument uses a low-Z gamma-to-electron convertor plate and high pressure gas to convert MeV gammas into UV/visible Cherenkov photons for fast optical detection. This is a follow-on diagnostic from previous versions, with two notable differences: the pressure of the gas is four times higher, and it allows the use of fluorinated gas, requiring metal seals...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910351/calibration-of-the-ohrex-high-resolution-imaging-crystal-spectrometer-at-the-livermore-electron-beam-ion-traps
#16
N Hell, P Beiersdorfer, E W Magee, G V Brown
We report the calibration of the Orion High-Resolution X-ray (OHREX) imaging crystal spectrometer at the EBIT-I electron beam ion trap at Livermore. Two such instruments, dubbed OHREX-1 and OHREX-2, are fielded for plasma diagnostics at the Orion laser facility in the United Kingdom. The OHREX spectrometer can simultaneously house two spherically bent crystals with a radius of curvature of r = 67.2 cm. The focusing properties of the spectrometer allow both for larger distance to the source due to the increase in collected light and for observation of extended sources...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910018/fluorescence-in-situ-hybridization-probe-validation-for-clinical-use
#17
Jun Gu, Janice L Smith, Patricia K Dowling
In this chapter, we provide a systematic overview of the published guidelines and validation procedures for fluorescence in situ hybridization (FISH) probes for clinical diagnostic use. FISH probes-which are classified as molecular probes or analyte-specific reagents (ASRs)-have been extensively used in vitro for both clinical diagnosis and research. Most commercially available FISH probes in the United States are strictly regulated by the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), the Centers for Medicare & Medicaid Services (CMS) the Clinical Laboratory Improvement Amendments (CLIA), and the College of American Pathologists (CAP)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909793/epidermolysis-bullosa-house-austria-and-epidermolysis-bullosa-clinical-network-example-of-a-centre-of-expertise-implemented-in-a-european-reference-network-to-face-the-burden-of-a-rare-disease
#18
Martin Laimer, Gabriela Pohla-Gubo, Anja Diem, Christine Prodinger, Johann W Bauer, Helmut Hintner
Accurately addressing the diverse and complex issues of rare diseases (RD) in terms of prevention, recognition, diagnosis, treatment, care and research along key RD specificities, such as great heterogeneity, a limited number of patients, scarcity of relevant knowledge and expertise as well as enormous costs for patient care is a challenging task for healthcare providers and authorities that makes a supranational approach particularly feasible. The European Union has acknowledged RD matters by several initiatives, including efforts to implement national centres of expertise and European reference networks as well as a cross-border referral mechanism to foster access to expert services and to boost dissemination of clinical expertise and research activities...
December 1, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27909777/quantitative-determination-of-the-neurotoxin-%C3%AE-n-methylamino-l-alanine-bmaa-by-capillary-electrophoresis-tandem-mass-spectrometry
#19
Elliott S Kerrin, Robert L White, Michael A Quilliam
Recent reports of the widespread occurrence of the neurotoxin β-N-methylamino-L-alanine (BMAA) in cyanobacteria and particularly seafood have raised concerns for public health. LC-MS/MS is currently the analytical method of choice for BMAA determinations but incomplete separation of isomeric and isobaric compounds, matrix suppression and conjugated forms are plausible limitations. In this study, capillary electrophoresis (CE) coupled with MS/MS has been developed as an alternative method for the quantitative determination of free BMAA...
December 1, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27909687/morphogenesis-of-human-embryonic-stem-cells-into-mature-neurons-under-in-vitro-culture-conditions
#20
Geeta Shroff
AIM: To describe the morphogenesis of different neuronal cells from the human embryonic stem cell (hESC) line, SCT-N, under in vitro culture conditions. METHODS: The directed neuronal cell line was produced from a single, spare, pre-implantation stage fertilized ovum that was obtained during a natural in vitro fertilization process. The hESCs were cultured and maintained as per our proprietary in-house technology in a Good Manufacturing Practice, Good Laboratory Practice and Good Tissue Practice compliant laboratory...
November 20, 2016: World Journal of Experimental Medicine
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