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https://www.readbyqxmd.com/read/28445806/patient-engagement-at-the-margins-health-care-providers-assessments-of-engagement-and-the-structural-determinants-of-health-in-the-safety-net
#1
Mark D Fleming, Janet K Shim, Irene Yen, Ariana Thompson-Lastad, Sara Rubin, Meredith Van Natta, Nancy J Burke
Increasing "patient engagement" has become a priority for health care organizations and policy-makers seeking to reduce cost and improve the quality of care. While concepts of patient engagement have proliferated rapidly across health care settings, little is known about how health care providers make use of these concepts in clinical practice. This paper uses 20 months of ethnographic and interview research carried out from 2015 to 2016 to explore how health care providers working at two public, urban, safety-net hospitals in the United States define, discuss, and assess patient engagement...
April 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28445727/environmental-enrichment-induces-pericyte-and-iga-dependent-wound-repair-and-lifespan-extension-in-a-colon-tumor-model
#2
Benjamin D Bice, Megan R Stephens, Stephanie J Georges, Ashlee R Venancio, Peter C Bermant, Annika V Warncke, Kajsa E Affolter, Julio R Hidalgo, Melinda L Angus-Hill
Environmental enrichment (EE) replicates mind-body therapy by providing complex housing to laboratory animals to improve their activity levels, behavior, and social interactions. Using a Tcf4(Het/+)Apc(Min/+)-mediated model of colon tumorigenesis, we found that EE vastly improved the survival of tumor-bearing animals, with differential effect on tumor load in male compared to female animals. Analysis of Tcf4(Het/+)Apc(Min/+) males showed drastically reduced expression of circulating inflammatory cytokines and induced nuclear hormone receptor (NHR) signaling, both of which are common in the wound repair process...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28445636/disposable-autonomous-device-for-rapid-swab-to-result-diagnosis-of-influenza
#3
Shichu Huang, Koji Abe, Steven Bennett, Tinny Liang, Paula D Ladd, Lindsay Yokobe, Caitlin E Anderson, Kamal Shah, Josh Bishop, Mike Purfield, Peter C Kauffman, Sai Paul, AnneMarie E Welch, Bonnie Strelitz, Kristin Follmer, Kelsey Pullar, Luis Sanchez-Erebia, Emily Gerth-Guyette, Gonzalo J Domingo, Eileen Klein, Janet A Englund, Elain Fu, Paul Yager
A prototype of a self-contained, automated, disposable device for chemically-amplified protein-based detection of influenza virus from nasal swab specimens was developed and evaluated in a clinical setting. The device required only simple specimen manipulation without any dedicated instrumentation or specialized training by the operator for interpretation. The device was based on a sandwich immunoassay for influenza virus nucleoprotein; it used an enzyme-labeled antibody and a chromogenic substrate to provide an amplified visible signal, in a two-dimensional paper network format...
April 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28445464/burgess-shale-fossils-illustrate-the-origin-of-the-mandibulate-body-plan
#4
Cédric Aria, Jean-Bernard Caron
Retracing the evolutionary history of arthropods has been one of the greatest challenges in biology. During the past decade, phylogenetic analyses of morphological and molecular data have coalesced towards the conclusion that Mandibulata, the most diverse and abundant group of animals, is a distinct clade from Chelicerata, in that its members possess post-oral head appendages specialized for food processing, notably the mandible. The origin of the mandibulate body plan, however, which encompasses myriapods, crustaceans and hexapods, has remained poorly documented...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445167/spatial-features-of-dose-surface-maps-from-deformably-registered-plans-correlate-with-late-gastrointestinal-complications
#5
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
This study investigates the associations between spatial distribution of dose to the rectal surface and observed gastrointestinal toxicities after deformably registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate brachytherapy (HDRBT) prostate cancer treatment. The study contains data for 118 patients where the HDRBT CT was deformably-registered to the EBRT CT. The EBRT and registered HDRBT TG43 dose distributions in a reference 2 Gy/fraction were 3D-summed. Rectum dose-surface maps (DSMs) were obtained by virtually unfolding the rectum surface slice-by-slice...
April 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28445010/detection-of-serum-antibodies-to-hepatitis-e-virus-based-on-hev-genotype-3-orf2-capsid-protein-expressed-in-nicotiana-benthamiana
#6
Milena Mazalovska, Nikola Varadinov, Tsvetoslav Koynarski, Ivan Minkov, Pavel Teoharov, George P Lomonossoff, Gergana Zahmanova
BACKGROUND: Hepatitis E virus (HEV) causes epidemics in developing countries and is primarily transmitted through the fecal-oral route. There have been recent reports on the zoonotic spread of the virus, and several animal species, primarily pigs, have been recognized as reservoirs of HEV. Because of its possible spread, there is an urgent need of a method for the cost-effective production of HEV proteins that can be used as diagnostic antigens for the serological detection of anti-HEV antibodies...
July 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28444635/the-leukocentric-theory-of-neurological-disorder-a-manifesto
#7
Robert Fern
Approximately half of the human brain is composed of white matter (WM), a specialized tissue housing the axonal projection of neurons and their necessary supporting glial cells. Axons course long distances from their parent soma, have a delicate structure, large surface area and in many cases are dependent upon a uniquely close morphological arrangement with myelinating oligodendrocyte partners; all factors that may predispose them to injury and disease. WM damage is central to a range of well-characterized disorders including multiple sclerosis and spinal cord injury and is also makes a significant contribution to disorders often considered to be largely focused in gray matter; for example, in stroke where ~49% of injury by volume is located in WM...
April 25, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28444478/the-association-between-geometry-and-wall-stress-in-emergently-repaired-abdominal-aortic-aneurysms
#8
Sathyajeeth S Chauhan, Carlos A Gutierrez, Mirunalini Thirugnanasambandam, Victor De Oliveira, Satish C Muluk, Mark K Eskandari, Ender A Finol
Abdominal aortic aneurysm (AAA) is a prevalent cardiovascular disease characterized by the focal dilation of the aorta, which supplies blood to all the organs and tissues in the systemic circulation. With the AAA increasing in diameter over time, the risk of aneurysm rupture is generally associated with the size of the aneurysm. If diagnosed on time, intervention is recommended to prevent AAA rupture. The criterion to decide on surgical intervention is determined by measuring the maximum diameter of the aneurysm relative to the critical value of 5...
April 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28444470/sexual-orientation-differences-in-health-and-wellbeing-among-women-living-with-hiv-in-canada-findings-from-a-national-cohort-study
#9
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Alexandra de Pokomandy, Kath Webster, Tracey Conway, Mona Loutfy
Sexual orientation differences in health and wellbeing among women living with HIV (WLH) are underexplored. Limited research available, however, suggests that sexual minority WLH may experience barriers to HIV care. Cross-sectional baseline data was analyzed from a Canadian cohort study with WLH (sexual minority women [SMW]: n = 180; heterosexual women: n = 1240). SMW (median age 38 years, IQR 13) included bisexual (58.9%), lesbian (17.8%) and other sexualities (23.3%). In multivariable analyses adjusting for age, poverty, education, and ethnicity, SMW identity was associated with increased odds of: clinical (80% vs...
April 25, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28444451/new-tumor-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumors-nasal-cavity-paranasal-sinuses-and-skull-base
#10
REVIEW
Lester D R Thompson, Alessandro Franchi
The World Health Organization recently published the 4th edition of the Classification of Head and Neck Tumors, including several new entities, emerging entities, and significant updates to the classification and characterization of tumor and tumor-like lesions, specifically as it relates to nasal cavity, paranasal sinuses, and skull base in this overview. Of note, three new entities (NUT carcinoma, seromucinous hamartoma, biphenotypic sinonasal sarcoma,) were added to this section, while emerging entities (SMARCB1-deficient carcinoma and HPV-related carcinoma with adenoid cystic-like features) and several tumor-like entities (respiratory epithelial adenomatoid hamartoma, chondromesenchymal hamartoma) were included as provisional diagnoses or discussed in the setting of the differential diagnosis...
April 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28444384/e-science-technologies-in-a-workflow-for-personalized-medicine-using-cancer-screening-as-a-case-study
#11
Ola Spjuth, Andreas Karlsson, Mark Clements, Keith Humphreys, Emma Ivansson, Jim Dowling, Martin Eklund, Alexandra Jauhiainen, Kamila Czene, Henrik Grönberg, Pär Sparén, Fredrik Wiklund, Abbas Cheddad, Þorgerður Pálsdóttir, Mattias Rantalainen, Linda Abrahamsson, Erwin Laure, Jan-Eric Litton, Juni Palmgren
Objective: We provide an e-Science perspective on the workflow from risk factor discovery and classification of disease to evaluation of personalized intervention programs. As case studies, we use personalized prostate and breast cancer screenings. Materials and Methods: We describe an e-Science initiative in Sweden, e-Science for Cancer Prevention and Control (eCPC), which supports biomarker discovery and offers decision support for personalized intervention strategies...
April 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28444299/environmental-factors-associated-with-disease-flare-in-juvenile-and-adult-dermatomyositis
#12
Gulnara Mamyrova, Lisa G Rider, Alison Ehrlich, Olcay Jones, Lauren M Pachman, Robert Nickeson, Lisa G Criscone-Schreiber, Lawrence K Jung, Frederick W Miller, James D Katz
Objective.: The aim was to assess environmental factors associated with disease flare in juvenile and adult dermatomyositis (DM). Methods.: An online survey of DM patients from the USA and Canada examined smoking, sun exposure, infections, medications, vaccines, stressful life events and physical activity during the 6 months before flares, or in the past 6 months in patients without flares. Differences were evaluated by χ 2 and Fisher's exact tests, and significant univariable results were examined in multivariable logistic regression...
April 21, 2017: Rheumatology
https://www.readbyqxmd.com/read/28444240/non-specific-effects-of-oral-polio-vaccine-on-diarrheal-burden-and-etiology-among-bangladeshi-infants
#13
Alexander Upfill-Brown, Mami Taniuchi, James A Platts-Mills, Beth Kirkpatrick, Stacey L Burgess, M Steven Oberste, William Weldon, Eric Houpt, Rashidul Haque, K Zaman, William A Petri
Background: As the global polio eradication initiative prepares to cease use of oral polio vaccine (OPV) in 2020, there is increasing interest in understanding if oral vaccination provides non-specific immunity to other infections so that the consequences of this transition can be effectively planned for and mitigated. Methods: Data was collected from infants in an urban slum in Bangladesh (Mirpur, Dhaka) as part of the PROVIDE study. Following vaccination with tOPV at 6,10, and 14 weeks, infants were randomly assigned to receive tOPV (n=315) or IPV (n=299) at 39 weeks...
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28444059/-anthropometric-profile-of-children-in-accordance-with-the-structure-of-daycare-centers
#14
Dixis Figueroa Pedraza
The scope of this article is to evaluate the structure of public daycare centers and the anthropometric profile of children in the city of Campina Grande in the State of Paraíba, Brazil. It is a cross-sectional study that involved 793 children attended in daycare centers. Information to describe the daycare centers were included (structure related to the capacity of demand and the processing power of school meals, reception system of children, location area) and the anthropometric status of the children (Height/Age, Weight/Height)...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28443973/the-experience-of-rural-families-who-remain-in-halfway-houses-during-cancer-treatment
#15
Nara Marilene Oliveira Girardon-Perlini, Isabel Cristina Pacheco Van der Sand, Margrid Beuter, Bruna Vanessa Costa da Rosa
Objective: to understand the experience of rural families who remain in halfway houses during the cancer treatment of an adult family member. Methods: qualitative research based on Symbolic Interaction and narrative research. Seven rural families participated in the study, 14 people staying in halfway houses in Santa Maria, Rio Grande do Sul, Brazil. The data obtained through interviews from November 2010 to May 2011 were analyzed with emphasis on content. Results: the three themes were: halfway houses as a reference for permanence during treatment, everyday life and living together in the halfway house...
April 20, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28443803/a-strategy-for-early-risk-predictions-of-clinical-drug-drug-interactions-involving-the-gastroplus-tm-ddi-module-for-time-dependent-cyp-inhibitors
#16
Anna-Karin Sohlenius-Sternbeck, Gabrielle Meyerson, Ann-Louise Hagbjörk, Sanja Juric, Ylva Terelius
1. A set of reference compounds for time-dependent inhibition (TDI) of cytochrome P450 with available literature data for kinact and KI was used to predict clinical implications using the GastroPlus(TM) software. Comparisons were made to in vivo literature interaction data. 2. The predicted AUC ratios (AUC+inhibitor/AUCcontrol) could be compared with the observed ratios from literature for all compounds with detailed information about in vivo administration, pharmacokinetics and in vivo interactions (N = 21)...
April 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28443751/a-prospective-cohort-study-assessing-differences-in-cosmetic-appreciation-of-lateralization-while-smiling-in-patients-with-a-peripheral-facial-palsy
#17
Robin E Luijmes, Carien H G Beurskens, Sjaak Pouwels, Koen J A O Ingels
We investigated the differences in cosmetic appreciation of patients with a left and a right peripheral facial palsy (PFP) while smiling. Smiling pictures of patients with a facial palsy with House-Brackmann II-VI were reversed as a mirror image and offered as a pair of pictures, together with the true image. Twenty-six patients with a PFP and 24 medical professionals familiar with facial palsy were asked to choose the most attractive photograph. Patients rated their own pictures. Medical professionals preferred pictures of patients with a right and left PFP in, respectively, a mean of 43...
April 26, 2017: Laterality
https://www.readbyqxmd.com/read/28443674/perinatal-bacterial-exposure-contributes-to-il-13-aeroallergen-response
#18
Benjamin A Turturice, Ravi Ranjan, Brian Nguyen, Lauren M Hughes, Kalista E Andropolis, Diane R Gold, Augusto A Litonjua, Emily Oken, David L Perkins, Patricia W Finn
There is a high prevalence of aeroallergen sensitivity in asthmatic populations, and seroreactivity to aeroallergens early in infancy is associated with increased risk of developing asthma later in life. In addition to allergen sensitivity, asthma development has been associated with differential microbial exposure and infection in early life. We have has previously shown that cord blood mononuclear cells respond to common aeroallergens (i.e., house dust mite (Der f1), cockroach (Bla g2)) as assayed by lymphoproliferation and cytokine (IL-13, IFN-γ) production...
April 26, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28443536/effects-of-nesting-material-on-energy-homeostasis-in-balb-canncrl-c57bl-6ncrl-and-crl-cd1-icr-mice-housed-at-20-%C3%A2-c
#19
Daniel Taylor, Angela Green, Brianna Gaskill
Discrepancies exist between the preferred temperature range for mice (26 to 32 °C) and current recommendations (20 to26 °C), which may alter metabolism and negatively affect studies using mice. Previous research indicates that nesting materialcan alleviate cold stress in mice; therefore, we sought to determine the effects of the amount of nesting material provided(0, 6, or 12 g) on heat energy loss and energy balance in 3 mouse strains housed at currently recommended temperatures duringthe daytime, a period of presumed inactivity...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28443289/frequency-and-duration-of-fecal-shedding-of-salmonella-enteritidis-by-experimentally-infected-laying-hens-housed-in-enriched-colony-cages-at-different-stocking-densities
#20
Richard K Gast, Rupa Guraya, Deana R Jones, Kenneth E Anderson, Darrin M Karcher
Human infections with Salmonella Enteritidis are often attributed to the consumption of contaminated eggs, so the prevalence of this pathogen in egg-laying poultry is an important public health risk factor. Numerous and complex environmental influences on Salmonella persistence and transmission are exerted by management practices and housing facilities used in commercial egg production. In recent years, the animal welfare implications of poultry housing systems have guided the development of alternatives to traditional cage-based housing, but their food safety consequences are not yet fully understood...
2017: Frontiers in Veterinary Science
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