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Bronchopulmonary Dysplasia

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https://www.readbyqxmd.com/read/30005089/epidermal-growth-factor-receptor-inhibition-with-gefitinib-does-not-alter-lung-responses-to-mechanical-ventilation-in-fetal-preterm-lambs
#1
T Brett Kothe, Emily Royse, Matthew W Kemp, Haruo Usuda, Masatoshi Saito, Gabrielle C Musk, Alan H Jobe, Noah H Hillman
BACKGROUND: Epidermal growth factor receptor (EGFR) is important for airway branching and lung maturation. Mechanical ventilation of preterm lambs causes increases in EGFR and EGFR ligand mRNA in the lung. Abnormal EGFR signaling may contribute to the development of bronchopulmonary dysplasia. HYPOTHESIS: Inhibition of EGFR signaling will decrease airway epithelial cell proliferation and lung inflammation caused by mechanical ventilation in preterm, fetal sheep...
2018: PloS One
https://www.readbyqxmd.com/read/30001649/about-the-role-of-polysomnography-in-weaning-and-titration-of-home-oxygen-therapy-in-children-with-bronchopulmonary-dysplasia
#2
Carlo De Pieri, Alessandro Amaddeo, Brigitte Fauroux
No abstract text is available yet for this article.
July 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30001393/effect-of-progesterone-on-smad-signaling-and-tgf-%C3%AE-smad-regulated-genes-in-lung-epithelial-cells
#3
Steffen Kunzmann, Barbara Ottensmeier, Christian P Speer, Markus Fehrholz
The effect of endogenous progesterone and/or exogenous pre- or postnatal progesterone application on lung function of preterm infants is poorly defined. While prenatal progesterone substitution may prevent preterm birth, in vitro and in vivo data suggest a benefit of postnatal progesterone replacement on the incidence and severity of bronchopulmonary dysplasia (BPD). However, the molecular mechanisms responsible for progesterone's effects are undefined. Numerous factors are involved in lung development, airway inflammation, and airway remodeling: the transforming growth factor beta (TGF-β)/mothers against decapentaplegic homolog (Smad) signaling pathway and TGF-β-regulated genes, such as connective tissue growth factor (CTGF), transgelin (TAGLN), and plasminogen activator inhibitor-1 (PAI-1)...
2018: PloS One
https://www.readbyqxmd.com/read/29999603/sustained-lung-inflation-at-birth-via-short-binasal-prong-in-very-low-birth-weight-preterm-infants-a-retrospective-study
#4
Mehmet Buyuktiryaki, Hayriye G Kanmaz, Nilufer Okur, Handan Bezirganoglu, Buse Bekmez, Gulsum Kadioglu Simsek, Fuat E Canpolat, Suna S Oguz, Cuneyt Tayman
BACKGROUND AND OBJECTIVES: It is believed, that sustained lung inflation (SLI) at birth in preterm infants reduces the need for mechanical ventilation (MV) and improves respiratory outcomes. The aim of this study was to compare need for MV in preterm infants at high risk for respiratory distress syndrome (RDS) after prophylactic SLI via short binasal prongs at birth combined with early nasal continuous positive airway pressure (nCPAP) versus nCPAP alone. METHODS: Medical records of infants born at 260/7 to 296/7 weeks gestation through 2015 and 2017 were retrospectively assessed...
July 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29996153/hypertensive-disorders-during-pregnancy-and-risk-of-bronchopulmonary-dysplasia-in-very-preterm-infants
#5
Gustavo Marcondes Rocha, Filipa Flor de Lima, Ana Paula Machado, Hercília Areias Guimarães
INTRODUCTION:  It is not yet fully known whether hypertensive disorders (HTD) during pregnancy impose an increased risk of development of bronchopulmonary dysplasia (BPD) in preterm newborn infants. OBJECTIVE:  To test the hypothesis that preeclampsia and other HTD are associated with the development of BPD in preterm infants. MATERIALS AND METHODS:  Data on mothers and preterm infants with gestational age 24 to 30 weeks were prospectively analyzed in 11 Portuguese level III centers...
July 11, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29995082/assessment-of-the-neuropsychomotor-development-in-the-first-year-of-life-of-premature-infants-with-and-without-bronchopulmonary-dysplasia
#6
Letycia Vieira Silva, Lúcio Borges de Araújo, Vivian Mara Gonçalves de Oliveira Azevedo
OBJECTIVE: To compare the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia. METHODS: A cross-sectional retrospective study was conducted between January 1, 2014, and December 30, 2015, with premature infants weighing < 1,500g at birth and diagnosed with bronchopulmonary dysplasia at the corrected ages of 6 and 9 months, assessed using the DENVER II Developmental Screening Test. Quantitative variables were described as the means, medians and standard deviations...
April 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29990355/riociguat-prevents-hyperoxia-induced-lung-injury-and-pulmonary-hypertension-in-neonatal-rats-without-effects-on-long-bone-growth
#7
Keyur Donda, Ronald Zambrano, Younghye Moon, Justin Percival, Ruben Vaidya, Fredrick Dapaah-Siakwan, Shihua Luo, Matthew R Duncan, Yong Bao, Luqing Wang, Ling Qin, Merline Benny, Karen Young, Shu Wu
Bronchopulmonary dysplasia (BPD) remains the most common and serious chronic lung disease of premature infants. Severe BPD complicated with pulmonary hypertension (PH) increases the mortality of these infants. Riociguat is an allosteric soluble guanylate cyclase stimulator and is approved by the FDA for treating PH in adults. However, it has not been approved for use in neonates due to concern for adverse effects on long bone growth. To address this concern we investigated if administration of riociguat is beneficial in preventing hyperoxia-induced lung injury and PH without side effects on long bone growth in newborn rats...
2018: PloS One
https://www.readbyqxmd.com/read/29987124/endothelial-colony-forming-cells-in-young-adults-born-preterm-a-novel-link-between-neonatal-complications-and-adult-risks-for-cardiovascular-disease
#8
Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Ying He, Anik Cloutier, Rafael Oliveira Fernandes, Chanel Béland, Megan R Sutherland, Jacques Delfrate, Daniel Curnier, Jean-Luc Bigras, Alain Rivard, Bernard Thébaud, Thuy Mai Luu, Anne Monique Nuyt
BACKGROUND: Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm-born infants, especially endothelial colony-forming cells (ECFC), show enhanced susceptibility to prematurity-related pro-oxidant stress. Whether ECFC dysfunction is present in adulthood following preterm birth is unknown. METHODS AND RESULTS: This cross-sectional observational study includes 55 preterm-born (≤29 gestational weeks) young adults (18-29 years old, 38% male) and 55 sex- and age-matched full-term controls...
July 9, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29979483/relationship-between-clinical-severity-of-new-bronchopulmonary-dysplasia-and-hrct-abnormalities-in-vlbw-infants
#9
Tae-Jung Sung, Sook M Hwang, Min Y Kim, Shin G Park, Ka Y Choi
BACKGROUND: To assess the relationship between HRCT abnormalities and the clinical severity of "new" bronchopulmonary dysplasia (BPD) and respiratory assistance in <1500 g preterm infants. METHODS: HRCT was performed at the time of discharge in 109 preterm infants with BPD who were born between 2008 and 2014. BPD severity was defined as mild, moderate, or severe according to the NIH diagnostic criteria. Total HRCT scores for each infant were obtained from the sum of the number of BPD lobes assessed by two radiologists: a hyperaeration score (Hs) composed of decreased attenuation, mosaic attenuation, and bulla/bleb, and a parenchyma score (Ps) composed of linear lesions, consolidation, bronchial wall thickening, and bronchiectasis...
July 6, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29977013/ntprobnp-as-a-surrogate-biomarker-for-early-screening-of-pulmonary-hypertension-in-preterm-infants-with-bronchopulmonary-dysplasia
#10
Soham Dasgupta, Ashraf M Aly, Michael H Malloy, Anthony O Okorodudu, Sunil K Jain
OBJECTIVE: Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants. STUDY DESIGN: Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups...
July 6, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29974208/neonatal-hypertension-an-educational-review
#11
Matthew W Harer, Alison L Kent
Hypertension is encountered in up to 3% of neonates and occurs more frequently in neonates requiring hospitalization in the neonatal intensive care unit (NICU) than in neonates in newborn nurseries or outpatient clinics. Former NICU neonates are at higher risk of hypertension secondary to invasive procedures and disease-related comorbidities. Accurate measurement of blood pressure (BP) remains challenging, but new standardized methods result in less measurement error. Multiple factors contribute to the rapidly changing BP of a neonate: gestational age, postmenstrual age (PMA), birth weight, and maternal factors are the most significant contributors...
July 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29972635/improved-growth-and-developmental-activity-post-tracheostomy-in-preterm-infants-with-severe-bpd
#12
Jun Luo, Suzanne Shepard, Kathleen Nilan, Audrey Wood, Heather M Monk, Erik A Jensen, Ann T Harrington, Kathryn Maschhoff, Haresh Kirpalani, Zhichun Feng, Huayan Zhang
OBJECTIVES: To examine growth, sedation needs, and participation in developmental activities before and after tracheostomy among infants with severe bronchopulmonary dysplasia. METHODS: Retrospective analysis of infants born at <32 weeks' gestation or birth weights <1500 g with severe BPD who underwent tracheostomy placement between January 1, 2010 and December 31, 2016 in a quaternary referral newborn and infant intensive care unit. Changes in growth parameters and frequency/type of participation in physical therapy sessions performed during the 4-weeks before tracheostomy and 4-weeks after the first tracheostomy tube change were compared...
July 3, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29972114/-clinical-effect-of-bubble-nasal-continuous-positive-airway-pressure-versus-conventional-nasal-continuous-positive-airway-pressure-in-respiratory-support-for-preterm-infants-with-neonatal-respiratory-distress-syndrome
#13
Xian-Xiao Shu, Chao Chen, Jun Tang, Hua Wang
OBJECTIVE: To study the clinical effect and safety of bubble nasal continuous positive airway pressure (BNCPAP) versus conventional nasal continuous positive airway pressure (nCPAP) in respiratory support for preterm infants with neonatal respiratory distress syndrome (NRDS). METHODS: A retrospective analysis was performed for the clinical data of 130 preterm infants with NRDS. Among them, 69 underwent BNCPAP and 61 underwent nCPAP. The two groups were compared in terms of mortality rate, duration of respiratory support, use of pulmonary surfactant (PS), and treatment failure rate, and the incidence rates of bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP), as well as the changes in blood gas pH, partial pressure of oxygen, and partial pressure of carbon dioxide...
June 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29971428/association-of-maternal-diabetes-with-neonatal-outcomes-of-very-preterm-and-very-low-birth-weight-infants-an-international-cohort-study
#14
Martina Persson, Prakesh S Shah, Franca Rusconi, Brian Reichman, Neena Modi, Satoshi Kusuda, Liisa Lehtonen, Stellan Håkansson, Junmin Yang, Tetsuya Isayama, Marc Beltempo, Shoo Lee, Mikael Norman
Importance: Diabetes in pregnancy is associated with a 2-times to 3-times higher rate of very preterm birth than in women without diabetes. Very preterm infants are at high risk of death and severe morbidity. The association of maternal diabetes with these risks is unclear. Objective: To determine the associations between maternal diabetes and in-hospital mortality, as well as neonatal morbidity in very preterm infants with a birth weight of less than 1500 g. Design, Setting, Participants: This retrospective cohort study was conducted at 7 national networks in high-income countries that are part of the International Neonatal Network for Evaluating Outcomes in Neonates and used prospectively collected data on 76 360 very preterm, singleton infants without malformations born between January 1, 2007, and December 31, 2015, at 24 to 31 weeks' gestation with birth weights of less than 1500 g, 3280 (4...
July 2, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29968443/radiation-exposure-in-very-low-birth-weight-infants
#15
Filipa Pinto, Gustavo Rocha, Filipa Flor-De-Lima, Henrique Soares, Isabel Ramos, Hercília Guimarães
BACKGROUND: The survival of very low birth weight (VLBW) infants increased in the past few decades. These neonates often require multiple diagnostic and management image procedures that involve ionizing radiation, which can have long term implications. The aim of our study was to evaluate the level of radiation exposure in VLBW infants during their stay in the neonatal intensive care unit (NICU). METHODS: We collected demographic and medical data of 149 VLBW who were admitted to our NICU between January 2011 and December 2014...
July 2, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29961407/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#16
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide centre-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabour rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 weeks gestation, occurring over a 7-year period. These were women who delivered > 24 hours after membrane rupture, and had no signs of chorioamnionitis or advanced labour at admission...
July 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29958703/patent-ductus-arteriosus-its-treatments-and-the-risks-of-pulmonary-morbidity
#17
REVIEW
Ronald I Clyman
A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and prolongs the need for mechanical ventilation. In preclinical trials, pharmacologic PDA closure leads to improved alveolarization and minimizes the impaired postnatal alveolar development that is the pathologic hallmark of bronchopulmonary dysplasia (BPD). Although routine prophylactic treatment of a PDA on the day of birth does not appear to offer any more protection against BPD than delaying treatment for 2-3 days, recent evidence from quality improvement trials suggests that early pharmacologic treatment decreases the incidence of BPD compared with a treatment approach that exposes infants to a moderate-to-large PDA shunt for the first 7-10 days after birth...
May 10, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29957288/ventilation-inhomogeneity-and-no-and-co-diffusing-capacity-in-ex-premature-school-children
#18
Jesper Kiehn Sørensen, Frederik Buchvald, Anna Korsgaard Berg, Paul D Robinson, Kim Gjerum Nielsen
AIM: Ex-premature school children show mild-to-moderate airway obstruction and decreased CO diffusing capacity. Multiple breath nitrogen washout (N2MBW) and NO diffusing capacity (DLNO) measurements may provide new insight into long-term pulmonary and vascular impairment in bronchopulmonary dysplasia (BPD). METHODS: We examined a randomly selected group of 70 ex-premature children (gestational age <28 weeks or birth weight <1500 g; 42 with and 28 without BPD) and 38 term-born healthy controls of 8-13 years of age...
July 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29957134/impaired-angiogenic-supportive-capacity-and-altered-gene-expression-profile-of-resident-cd146-mesenchymal-stromal-cells-isolated-from-hyperoxia-injured-neonatal-rat-lungs
#19
Jennifer J P Collins, Marissa A Lithopoulos, Claudia C Dos Santos, Nahla Issa, Marius A Möbius, Caryn Ito, Shumei Zhong, Arul Vadivel, Bernard Thébaud
Bronchopulmonary dysplasia (BPD), the most common complication of extreme preterm birth, can be caused by oxygen-related lung injury and is characterized by impaired alveolar and vascular development. Mesenchymal stromal cells (MSCs) have lung protective effects. Conversely, BPD is associated with increased MSCs in tracheal aspirates. We hypothesized that endogenous lung (L-)MSCs are perturbed in a well-established oxygen-induced rat model mimicking BPD features. Rat pups were exposed to 21% or 95% oxygen from birth to postnatal day 10...
June 29, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29952221/iloprost-attenuates-hyperoxia-mediated-impairment-of-lung-development-in-newborn-mice
#20
Nelida Olave, Charitharth Vivek Lal, Brian Halloran, Vineet Bhandari, Namasivayam Ambalavanan
Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals, and is increased in lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes production of cytoprotective prostaglandins such as prostacyclin (PGI2) as well as pro-inflammatory mediators such as thromboxane A2 (TxA2). Our objective was to determine whether iloprost, a synthetic analog of prostacyclin, would attenuate hyperoxia effects in the newborn mouse lung. To test this hypothesis, newborn C57BL/6 mice along with their dams were exposed to normoxia (21%) or hyperoxia (85% O2) from 4 to 14 days of age in combination with daily i...
June 28, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
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