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https://www.readbyqxmd.com/read/22064352/calm-af10-positive-leukemias-show-upregulation-of-genes-involved-in-chromatin-assembly-and-dna-repair-processes-and-of-genes-adjacent-to-the-breakpoint-at-10p12
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M A Mulaw, A Krause, A J Krause, A J Deshpande, L F Krause, A Rouhi, R La Starza, A Borkhardt, C Buske, C Mecucci, W-D Ludwig, C Lottaz, S K Bohlander
The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the CALM/AF10-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes...
May 2012: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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