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Blueprinting and assessment

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https://www.readbyqxmd.com/read/27913228/pd-l1-immunohistochemistry-assays-for-lung-cancer-results-from-phase-1-of-the-blueprint-pd-l1-ihc-assay-comparison-project
#1
Fred R Hirsch, Abigail McElhinny, Dave Stanforth, James Ranger-Moore, Malinka Jansson, Karina Kulangara, William Richardson, Penny Towne, Debra Hanks, Bharathi Vennapusa, Amita Mistry, Rasika Kalamegham, Steve Averbuch, James Novotny, Eric Rubin, Kenneth Emancipator, Ian McCaffery, J Andrew Williams, Jill Walker, John Longshore, Ming S Tsao, Keith M Kerr
BACKGROUND: The "Blueprint PD-L1 IHC Assay Comparison Project" is an industrial-academic collaborative partnership to provide information on the analytical and clinical comparability of four PD-L1 IHC assays used in clinical trials. METHODS: 39 NSCLC tumors were stained with four PD-L1 IHC assays (22C3, 28-8, SP 142 and SP 263) as used in the clinical trials. Three experts in interpreting their respective assays independently evaluated the percentages of tumor and immune cells staining positive at any intensity...
November 29, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27875171/vlat-development-of-a-visualization-literacy-assessment-test
#2
Sukwon Lee, Sung-Hee Kim, Bum Chul Kwon
The Information Visualization community has begun to pay attention to visualization literacy; however, researchers still lack instruments for measuring the visualization literacy of users. In order to address this gap, we systematically developed a visualization literacy assessment test (VLAT), especially for non-expert users in data visualization, by following the established procedure of test development in Psychological and Educational Measurement: (1) Test Blueprint Construction, (2) Test Item Generation, (3) Content Validity Evaluation, (4) Test Tryout and Item Analysis, (5) Test Item Selection, and (6) Reliability Evaluation...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27826153/need-for-formal-specialization-in-pharmacy-in-canada-a-survey-of-hospital-pharmacists
#3
Jonathan Penm, Neil J MacKinnon, Derek Jorgenson, Jun Ying, Jennifer Smith
BACKGROUND: The Blueprint for Pharmacy was a collaborative initiative involving all of the major pharmacy associations in Canada. It aimed to coordinate, facilitate, and be a catalyst for changes required to align pharmacy practice with the health care needs of Canadians. In partial fulfilment of this mandate, a needs assessment for specialist certification for pharmacists was conducted. OBJECTIVE: To conduct a secondary analysis of data from the needs assessment to determine the perceptions of hospital pharmacists regarding a formal certification process for pharmacist specialties in Canada...
September 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/27798022/parenting-acceptance-and-commitment-therapy-a-randomised-controlled-trial-of-an-innovative-online-course-for-families-of-children-with-cerebral-palsy
#4
Koa Whittingham, Jeanie Sheffield, Roslyn N Boyd
INTRODUCTION: Cerebral palsy (CP) impacts on the entire family in a manner that is long-term, complex and multifactorial. In addition, the quality of the parent-child relationship impacts on many and varied child outcomes, making the provision of easily accessible and evidence-based support to parents of children with CP a priority. This paper reports the protocol of a randomised controlled trial of an innovative and translatable online intervention, parenting acceptance and commitment therapy (PACT), for families of children with CP...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27770345/chemosensitivity-and-endocrine-sensitivity-in-clinical-luminal-breast-cancer-patients-in-the-prospective-neoadjuvant-breast-registry-symphony-trial-nbrst-predicted-by-molecular-subtyping
#5
Pat Whitworth, Peter Beitsch, Angela Mislowsky, James V Pellicane, Charles Nash, Mary Murray, Laura A Lee, Carrie L Dul, Michael Rotkis, Paul Baron, Lisette Stork-Sloots, Femke A de Snoo, Jennifer Beatty
PURPOSE: Hormone receptor-positive (HR+) tumors have heterogeneous biology and present a challenge for determining optimal treatment. In the Neoadjuvant Breast Registry Symphony Trial (NBRST) patients were classified according to MammaPrint/BluePrint subtyping to provide insight into the response to neoadjuvant endocrine therapy (NET) or neoadjuvant chemotherapy (NCT). OBJECTIVE: The purpose of this predefined substudy was to compare MammaPrint/BluePrint with conventional 'clinical' immunohistochemistry/fluorescence in situ hybridization (IHC/FISH) subtyping in 'clinical luminal' [HR+/human epidermal growth factor receptor 2-negative (HER2-)] breast cancer patients to predict treatment sensitivity...
October 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27746401/preclinical-determination-of-the-best-functional-position-for-transcatheter-heart-valves-implanted-in-rapid-deployment-bioprostheses
#6
Timm Schäfer, Christian Doose, Buntaro Fujita, Marc Utzenrath, Sandrine Egron, Christoph Schmitz, Smita Scholtz, Maximilian Kütting, Kavous Hakim-Meibodi, Jochen Börgermann, Jan Gummert, Ulrich Steinseifer, Stephan Ensminger
AIMS: The aim was to determine the best functional position of a transcatheter heart valve (THV) implanted as a valve-in-valve (ViV) procedure in small rapid deployment valves (RDV) in an in vitro model. METHODS AND RESULTS: A 21mm Perceval™, Enable™ or INTUITY™ RDV was mounted into a pulse duplicator and a 23mm balloon-expandable or a self-expanding THV was deployed (valve-in-valve) in two different positions. Under physiological hydrodynamic conditions, performance of the THV was characterized by mean transvalvular pressure gradient (MPG), effective orifice area (EOA) and regurgitation volume (RV)...
October 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27727234/genome-wide-chromatin-and-gene-expression-profiling-during-memory-formation-and-maintenance-in-adult-mice
#7
Tonatiuh Pena Centeno, Orr Shomroni, Magali Hennion, Rashi Halder, Ramon Vidal, Raza-Ur Rahman, Stefan Bonn
Recent evidence suggests that the formation and maintenance of memory requires epigenetic changes. In an effort to understand the spatio-temporal extent of learning and memory-related epigenetic changes we have charted genome-wide histone and DNA methylation profiles, in two different brain regions, two cell types, and three time-points, before and after learning. In this data descriptor we provide detailed information on data generation, give insights into the rationale of experiments, highlight necessary steps to assess data quality, offer guidelines for future use of the data and supply ready-to-use code to replicate the analysis results...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27716166/selection-into-medical-school-from-tools-to-domains
#8
Tom M Wilkinson, Tim J Wilkinson
BACKGROUND: Most research into the validity of admissions tools focuses on the isolated correlations of individual tools with later outcomes. Instead, looking at how domains of attributes, rather than tools, predict later success is likely to be more generalizable. We aim to produce a blueprint for an admissions scheme that is broadly relevant across institutions. METHODS: We broke down all measures used for admissions at one medical school into the smallest possible component scores...
October 3, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27696640/assessing-the-multiscale-architecture-of-muscular-tissue-with-q-space-magnetic-resonance-imaging-review
#9
Matthew P Hoffman, Erik N Taylor, George E Aninwene, Sakthivel Sadayappan, Richard J Gilbert
Contraction of muscular tissue requires the synchronized shortening of myofibers arrayed in complex geometrical patterns. Imaging such myofiber patterns with diffusion-weighted MRI reveals architectural ensembles that underlie force generation at the organ scale. Restricted proton diffusion is a stochastic process resulting from random translational motion that may be used to probe the directionality of myofibers in whole tissue. During diffusion-weighted MRI, magnetic field gradients are applied to determine the directional dependence of proton diffusion through the analysis of a diffusional probability distribution function (PDF)...
October 2, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27663482/immuno-pharmacodynamics-for-evaluating-mechanism-of-action-and-developing-immunotherapy-combinations
#10
REVIEW
Ralph E Parchment, Andrea Regier Voth, James H Doroshow, Jay A Berzofsky
Immunotherapy has become a major modality of cancer treatment, with multiple new classes of immunotherapeutics recently entering the clinic and obtaining market approval from regulatory agencies. While the promise of these therapies is great, so is the number of possible combinations not only with each other but also with small molecule therapeutics. Furthermore, the observation of unusual dose-response relationships suggests a critical dependency of drug effectiveness on the dosage regimen (dose and schedule)...
August 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27621080/best-of-both-worlds-combining-evidence-with-local-context-to-develop-a-nursing-shift-handover-blueprint
#11
Marian Smeulers, Hester Vermeulen
OBJECTIVE: Standardization of the handover process is deemed necessary to ensure continuity and safety of care. However, local context is considered of equal importance to improve the handover process. Our objective was to determine what recommendations on standardized shift handover nurses make, if we combine evidence from the literature with the local context of the nurses. DESIGN: A RAND-modified Delphi consensus process that combines evidence from systematic reviews with expert opinion of local nurses and an evaluation of the consensus process with a survey...
September 12, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27605616/parsing-the-behavioral-and-brain-mechanisms-of-third-party-punishment
#12
Matthew R Ginther, Richard J Bonnie, Morris B Hoffman, Francis X Shen, Kenneth W Simons, Owen D Jones, René Marois
UNLABELLED: The evolved capacity for third-party punishment is considered crucial to the emergence and maintenance of elaborate human social organization and is central to the modern provision of fairness and justice within society. Although it is well established that the mental state of the offender and the severity of the harm he caused are the two primary predictors of punishment decisions, the precise cognitive and brain mechanisms by which these distinct components are evaluated and integrated into a punishment decision are poorly understood...
September 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27579903/a-novel-method-for-calculating-potency-weighted-cumulative-phthalates-exposure-with-implications-for-identifying-racial-ethnic-disparities-among-u-s-reproductive-aged-women-in-nhanes-2001-2012
#13
Julia R Varshavsky, Ami R Zota, Tracey J Woodruff
Phthalates are ubiquitous chemicals linked to hormonal disruptions that affect reproduction and development. Multiple antiandrogenic phthalates exposure during fetal development can have greater impacts than individual exposure; thus, the National Academy of Sciences (NAS) recommends them for cumulative assessment. Using National Health and Nutrition Examination Survey data (NHANES, 2001-2012), we developed a potency-weighted sum of daily intake (∑androgen-disruptor; μg/kg/day) of di-n-butyl phthalate (DnBP), diisobutyl phthalate (DiBP), butyl benzyl phthalate (BBzP), and di(2-ethylhexyl) phthalate (DEHP) based on NAS recommendations, and included diethyl phthalate (DEP) and diisononyl phthalate (DiNP) in additional metrics (2005-2012)...
October 4, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27567831/developing-cognitive-markers-of-alzheimer-s-disease-for-primary-care-implications-for-behavioral-and-global-prevention
#14
Boaz Levy, Elena Tsoy, Samuel Gable
A comprehensive approach to the prevention of Alzheimer's disease (AD) warrants a synergy across multiple domains and procedures. Whereas the study of biological markers has mobilized major activity in the field, the development of cognitive markers is largely ignored, despite the unique advantages they may offer. Cognitive markers essentially assess the core clinical feature that biological markers intend to predict. In this respect, cognitive markers expand the foundation of preclinical diagnostics and disease staging in a manner that integrates both physiological and psychological factors...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27557119/whole-genomic-sequence-analysis-of-bacillus-infantis-defining-the-genetic-blueprint-of-strain-nrrl-b-14911-an-emerging-cardiopathogenic-microbe
#15
Chandirasegaran Massilamany, Akram Mohammed, John Dustin Loy, Tanya Purvis, Bharathi Krishnan, Rakesh H Basavalingappa, Christy M Kelley, Chittibabu Guda, Raúl G Barletta, Etsuko N Moriyama, Timothy P L Smith, Jay Reddy
BACKGROUND: We recently reported the identification of Bacillus sp. NRRL B-14911 that induces heart autoimmunity by generating cardiac-reactive T cells through molecular mimicry. This marine bacterium was originally isolated from the Gulf of Mexico, but no associations with human diseases were reported. Therefore, to characterize its biological and medical significance, we sought to determine and analyze the complete genome sequence of Bacillus sp. NRRL B-14911. RESULTS: Based on the phylogenetic analysis of 16S ribosomal RNA (rRNA) genes, sequence analysis of the 16S-23S rDNA intergenic transcribed spacers, phenotypic microarray, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry, we propose that this organism belongs to the species Bacillus infantis, previously shown to be associated with sepsis in a newborn child...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27432407/objective-structured-clinical-examination-for-pharmacy-students-in-qatar-cultural-and-contextual-barriers-to-assessment
#16
K J Wilby, E K Black, Z Austin, B Mukhalalati, S Aboulsoud, S I Khalifa
This study aimed to evaluate the feasibility and psychometric defensibility of implementing a comprehensive objective structured clinical examination (OSCE) on the complete pharmacy programme for pharmacy students in a Middle Eastern context, and to identify facilitators and barriers to implementation within new settings. Eight cases were developed, validated, and had standards set according to a blueprint, and were assessed with graduating pharmacy students. Assessor reliability was evaluated using inter-class coefficients (ICCs)...
April 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/27431472/putting-the-t-in-tools-a-roadmap-for-implementation-of-new-global-and-regional-transgender-guidance
#17
R Cameron Wolf, Darrin Adams, Robyn Dayton, Annette Verster, Joe Wong, Marcela Romero, Rafael Mazin, Edmund Settle, Tim Sladden, JoAnne Keatley
Transgender (trans) activists and global health partners have collaborated to develop new tools and guidance for assessing and addressing HIV and other health needs within trans populations. Trans women experience a heavy burden of HIV and other sexually transmitted infections (STIs), high incidence of violence and difficulties accessing gender-affirming services. At the same time, little has been published on trans men's health, HIV issues, needs and experiences. Young trans people are especially marginalized and vulnerable, with few programmes and services specifically tailored to their needs...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27428851/in-vivo-tumor-targeting-and-anti-tumor-effects-of-5-fluororacil-loaded-folic-acid-targeted-quantum-dot-system
#18
Ibrahim Birma Bwatanglang, Faruq Mohammad, Nor Azah Yusof, Jaafar Abdullah, Noorjahan Banu Alitheen, Mohd Zubir Hussein, Nadiah Abu, Nurul Elyani Mohammed, Noraini Nordin, Nur Rizi Zamberi, Swee Keong Yeap
In this study, we modulated the anti-cancer efficacy of 5-Fluorouracil (5-FU) using a carrier system with enhanced targeting efficacy towards folate receptors (FRs) expressing malignant tissues. The 5-FU drug was loaded onto Mn-ZnS quantum dots (QDs) encapsulated with chitosan (CS) biopolymer and conjugated with folic acid (FA) based on a simple wet chemical method. The formation of 5-FU drug loaded composite was confirmed using Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC)...
October 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27347756/quantitative-comparison-of-dna-methylation-assays-for-biomarker-development-and-clinical-applications
#19
(no author information available yet)
DNA methylation patterns are altered in numerous diseases and often correlate with clinically relevant information such as disease subtypes, prognosis and drug response. With suitable assays and after validation in large cohorts, such associations can be exploited for clinical diagnostics and personalized treatment decisions. Here we describe the results of a community-wide benchmarking study comparing the performance of all widely used methods for DNA methylation analysis that are compatible with routine clinical use...
July 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27329139/does-environmental-certification-in-coffee-promote-business-as-usual-a-case-study-from-the-western-ghats-india
#20
Arshiya Bose, Bhaskar Vira, Claude Garcia
Conservation initiatives are designed to address threats to forests and biodiversity, often through partnerships with natural-resource users who are incentivized to change their land-use and livelihood practices to avoid further biodiversity loss. In particular, direct incentives programmes that provide monetary benefits are commended for being effective in achieving conservation across short timescales. In biodiversity-rich areas, outside protected areas, such as coffee agroforestry systems, direct incentives, such as certification schemes, are used to motivate coffee producers to maintain native tree species, natural vegetation, restrict wildlife hunting, and conserve soil and water, in addition to encouraging welfare of workers...
December 2016: Ambio
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