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Blueprinting and assessment

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https://www.readbyqxmd.com/read/29025429/updated-clinical-guidelines-experience-major-reporting-limitations
#1
Robin W M Vernooij, Laura Martínez García, Ivan Dario Florez, Laura Hildago Armas, Michiel H F Poorthuis, Melissa Brouwers, Pablo Alonso-Coello
BACKGROUND: The Checklist for the Reporting of Updated Guidelines (CheckUp) was recently developed. However, so far, no systematic assessment of the reporting of updated clinical guidelines (CGs) exists. We aimed to examine (1) the completeness of reporting the updating process in CGs and (2) the inter-observer reliability of CheckUp. METHODS: We conducted a systematic assessment of the reporting of the updating process in a sample of updated CGs using CheckUp. We performed a systematic search to identify updated CGs published in 2015, developed by a professional society, reporting a systematic review of the evidence, and containing at least one recommendation...
October 12, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28961150/the-use-of-differential-item-functioning-dif-analysis-to-distinguish-between-similar-job-roles
#2
Nicole M Risk, James R Fidler
Two primary roles in the clinical laboratory are those of Medical Technologist (MT) and Medical Laboratory Technician (MLT). Job analyses, which form the foundation of test blueprints employed for credentialing practitioners, suggest a reasonable amount of overlap in the tasks performed by MTs and MLTs. However, credentialing assessments must clearly distinguish between the two roles and ensure that they address competencies appropriate to each practice designation. Differential item functioning (DIF) analysis techniques were applied to explore and differentiate the two laboratory practitioner job roles as an aspect of examination development...
2017: Journal of Applied Measurement
https://www.readbyqxmd.com/read/28935377/assessment-of-carbon-footprint-emissions-and-environmental-concerns-of-solid-waste-treatment-and-disposal-techniques-case-study-of-malaysia
#3
Amirhossein Malakahmad, Motasem S Abualqumboz, Shamsul Rahman M Kutty, Taher J Abunama
Malaysian authorities has planned to minimize and stop when applicable unsanitary dumping of waste as it puts human health and the environment at elevated risk. Cost, energy and revenue are mostly adopted to draw the blueprint of upgrading municipal solid waste management system, while the carbon footprint emissions criterion rarely acts asa crucial factor. This study aims to alert Malaysian stakeholders on the uneven danger of carbon footprint emissions of waste technologies. Hence, three scenarios have been proposed and assessed mainly on the carbon footprint emissions using the 2006 IPCC methodology...
September 18, 2017: Waste Management
https://www.readbyqxmd.com/read/28929359/immunohistochemical-versus-molecular-blueprint-and-mammaprint-subtyping-of-breast-carcinoma-outcome-results-from-the-eortc-10041-big-3-04-mindact-trial
#4
G Viale, F A de Snoo, L Slaets, J Bogaerts, L van 't Veer, E J Rutgers, M J Piccart-Gebhart, L Stork-Sloots, A Glas, L Russo, P Dell'Orto, K Tryfonidis, S Litière, F Cardoso
PURPOSE: This study compares immunohistochemical (IHC) versus molecular subtyping (BluePrint and MammaPrint) in the population of patients enrolled in MINDACT and outcome based on molecular subtyping (MS) versus surrogate pathological subtyping (PS) as defined by the 2013 St. Gallen guidelines. METHODS: MS classified patients in the following subtypes: Luminal A, Luminal B, HER-2-, and Basal-type. IHC/FISH for pathological subtyping (ER, PgR, HER-2, and Ki67) was centrally assessed in the European Institute of Oncology (n = 5806)...
September 19, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28864267/developing-the-blueprint-for-a-general-surgery-technical-skills-certification-examination-a-validation-study
#5
Sandra de Montbrun, Marisa Louridas, Peter Szasz, Kenneth A Harris, Teodor P Grantcharov
INTRODUCTION: There is a recognized need to develop high-stakes technical skills assessments for decisions of certification and resident promotion. High-stakes examinations requires a rigorous approach in accruing validity evidence throughout the developmental process. One of the first steps in development is the creation of a blueprint which outlines the potential content of examination. The purpose of this validation study was to develop an examination blueprint for a Canadian General Surgery assessment of technical skill certifying examination...
August 29, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28841874/science-of-health-care-delivery-milestones-for-undergraduate-medical-education
#6
Rachel D Havyer, Suzanne M Norby, Andrea N Leep Hunderfund, Stephanie R Starr, Tara R Lang, Alexandra P Wolanskyj, Darcy A Reed
BACKGROUND: The changing healthcare landscape requires physicians to develop new knowledge and skills such as high-value care, systems improvement, population health, and team-based care, which together may be referred to as the Science of Health Care Delivery (SHCD). To engender public trust and confidence, educators must be able to meaningfully assess physicians' abilities in SHCD. We aimed to develop a novel set of SHCD milestones based on published Accreditation Council for Graduate Medical Education (ACGME) milestones that can be used by medical schools to assess medical students' competence in SHCD...
August 25, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28811044/learning-how-to-teach-one-a-needs-assessment-of-the-state-of-faculty-development-within-the-consortium-of-the-american-college-of-surgeons-accredited-education-institutes
#7
John T Paige, Nehal N Khamis, Jeffrey B Cooper
BACKGROUND: Developing faculty competencies in curriculum development, teaching, and assessment using simulation is critical for the success of the Consortium of the American College of Surgeons Accredited Education Institutes program. The state of and needs for faculty development in the Accredited Education Institute community are unknown currently. The Faculty Development Committee of the Consortium of the Accredited Education Institutes conducted a survey of Accredited Education Institutes to ascertain what types of practices are used currently, with what frequency, and what needs are perceived for further programs and courses to guide the plan of action for the Faculty Development Committee...
August 12, 2017: Surgery
https://www.readbyqxmd.com/read/28800089/fitnet-s-internet-based-cognitive-behavioural-therapy-is-ineffective-and-may-impede-natural-recovery-in-adolescents-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-review
#8
REVIEW
Simin Ghatineh, Mark Vink
The Dutch Fatigue In Teenagers on the interNET (FITNET) study claimed that after 6 months, internet based cognitive behaviour therapy in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), led to a 63% recovery rate compared to 8% after usual care, and that this was maintained at long term follow up (LTFU). Our reanalysis shows that their post-hoc definition of recovery included the severely ill, the unblinded trial had no adequate control group and it used lax selection criteria as well as outcomes assessed via questionnaires rather than objective outcomes, further contributing to exaggerated recovery figures...
August 11, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28757337/differentiating-physicochemical-properties-between-ndris-and-snris-clinically-important-for-the-treatment-of-adhd
#9
Panpan Wang, Tingting Fu, Xiaoyu Zhang, Fengyuan Yang, Guoxun Zheng, Weiwei Xue, Yuzong Chen, Xiaojun Yao, Feng Zhu
BACKGROUND: Drugs available for treating attention-deficit hyperactivity disorder (ADHD) are mainly selective norepinephrine (sNRIs) and dual norepinephrine-dopamine (NDRIs) reuptake inhibitors. The major problem of sNRIs lines in their delayed onset of action and partial- or non-responses, which makes NDRIs distinguished in drug efficacy. Understanding of the differential binding modes of these 2 types of drugs to their corresponding targets can give great insights into the discovery of privileged drug-like scaffolds with improved efficacy...
November 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28690856/it-supported-integrated-care-pathways-for-diabetes-a-compilation-and-review-of-good-practices
#10
Hubertus Jm Vrijhoef, Antonio Giulio de Belvis, Matias de la Calle, Maria Stella de Sabata, Bastian Hauck, Sabrina Montante, Annette Moritz, Dario Pelizzola, Markku Saraheimo, Nick A Guldemond
INTRODUCTION: Integrated Care Pathways (ICPs) are a method for the mutual decision-making and organization of care for a well-defined group of patients during a well-defined period. The aim of a care pathway is to enhance the quality of care by improving patient outcomes, promoting patient safety, increasing patient satisfaction, and optimizing the use of resources. To describe this concept, different names are used, e.g. care pathways and integrated care pathways. Modern information technologies (IT) can support ICPs by enabling patient empowerment, better management, and the monitoring of care provided by multidisciplinary teams...
June 2017: International Journal of Care Coordination
https://www.readbyqxmd.com/read/28675542/white-matter-maturation-in-the-neonatal-brain-is-predictive-of-school-age-cognitive-capacities-in-children-born-very-preterm
#11
Kristin Keunen, Manon J Benders, Alexander Leemans, Petronella C Fieret-Van Stam, Lianne H Scholtens, Max A Viergever, René S Kahn, Floris Groenendaal, Linda S de Vries, Martijn P van den Heuvel
AIM: To investigate the association between white matter organization in the neonatal brain and cognitive capacities at early school age in children born very preterm. METHOD: Thirty children born very preterm (gestational age median 27.5wks, interquartile range [IQR] 25.5-29.5; 18 males, 12 females) were included in this retrospective observational cohort study. Diffusion-weighted imaging (DWI) had been performed on a 3T system in the neonatal period (median 41...
September 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28675202/natural-product-analogues-towards-a-blueprint-for-analogue-focused-synthesis
#12
REVIEW
Magnus W P Bebbington
For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed...
August 14, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28671715/the-critically-endangered-western-chimpanzee-declines-by-80
#13
Hjalmar S Kühl, Tenekwetche Sop, Elizabeth A Williamson, Roger Mundry, David Brugière, Genevieve Campbell, Heather Cohen, Emmanuel Danquah, Laura Ginn, Ilka Herbinger, Sorrel Jones, Jessica Junker, Rebecca Kormos, Celestin Y Kouakou, Paul K N'Goran, Emma Normand, Kathryn Shutt-Phillips, Alexander Tickle, Elleni Vendras, Adam Welsh, Erin G Wessling, Christophe Boesch
African large mammals are under extreme pressure from unsustainable hunting and habitat loss. Certain traits make large mammals particularly vulnerable. These include late age at first reproduction, long inter-birth intervals, and low population density. Great apes are a prime example of such vulnerability, exhibiting all of these traits. Here we assess the rate of population change for the western chimpanzee, Pan troglodytes verus, over a 24-year period. As a proxy for change in abundance, we used transect nest count data from 20 different sites archived in the IUCN SSC A...
September 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28609535/comparison-of-content-on-the-american-board-of-internal-medicine-maintenance-of-certification-examination-with-conditions-seen-in-practice-by-general-internists
#14
COMPARATIVE STUDY
Bradley Gray, Jonathan Vandergrift, Rebecca S Lipner, Marianne M Green
Importance: Success on the internal medicine (IM) examination is a central requirement of the American Board of Internal Medicine's (ABIM's) Maintenance of Certification program (MOC). Therefore, it is important to understand the degree to which this examination reflects conditions seen in practice, one dimension of content validity, which focuses on the match between content in the discipline and the topics on the examination questions. Objective: To assess whether the frequency of questions on IM-MOC examinations were concordant with the frequency of conditions seen in practice...
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28581813/dominance-of-metric-correlations-in-two-dimensional-neuronal-cultures-described-through-a-random-field-ising-model
#15
Lluís Hernández-Navarro, Javier G Orlandi, Benedetta Cerruti, Eduard Vives, Jordi Soriano
We introduce a novel random field Ising model, grounded on experimental observations, to assess the importance of metric correlations in cortical circuits in vitro. Metric correlations arise from both the finite axonal length and the heterogeneity in the spatial arrangement of neurons. The experiments consider the response of neuronal cultures to an external electric stimulation for a gradually weaker connectivity strength between neurons, and in cultures with different spatial configurations. The model can be analytically solved in the metric-free, mean-field scenario...
May 19, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28581678/ttn-genotype-is-associated-with-fascicle-length-and-marathon-running-performance
#16
Georgina K Stebbings, Alun G Williams, Adam J Herbert, Sarah J Lockey, Shane M Heffernan, Robert M Erskine, Christopher I Morse, Stephen H Day
Titin provides a molecular blueprint for muscle sarcomere assembly and sarcomere length can vary according to titin isoform expression. If variations in sarcomere length influence muscle fascicle length, this may provide an advantage for running performance. Thus the aim of this study was to investigate if the titin (TTN) rs10497520 polymorphism was associated with muscle fascicle length in recreationally active men (RA; n = 137) and marathon personal best time in male marathon runners (MR; n = 141). Fascicle length of the vastus lateralis was assessed in vivo using B-mode ultrasonography at 50% of muscle length in RA...
June 5, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28477085/linking-of-the-quality-of-life-in-neurological-disorders-neuro-qol-to-the-international-classification-of-functioning-disability-and-health
#17
Alex W K Wong, Stephen C L Lau, David Cella, Jin-Shei Lai, Guanli Xie, Lidian Chen, Chetwyn C H Chan, Allen W Heinemann
BACKGROUND: The quality of life in neurological disorders (Neuro-QoL) is a U.S. National Institutes of Health initiative that produced a set of self-report measures of physical, mental, and social health experienced by adults or children who have a neurological condition or disorder. OBJECTIVE: To describe the content of the Neuro-QoL at the item level using the World Health Organization's international classification of functioning, disability and health (ICF)...
May 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28471853/blueprint-for-sustainable-change-in-diversity-management-and-cultural-competence-lessons-from-the-national-center-for-healthcare-leadership-diversity-demonstration-project
#18
Janice L Dreachslin, Robert Weech-Maldonado, Judith Gail, Josué Patien Epané, Joyce Anne Wainio
How can healthcare leaders build a sustainable infrastructure to leverage workforce diversity and deliver culturally and linguistically appropriate care to patients? To answer that question, two health systems participated in the National Center for Healthcare Leadership's diversity leadership demonstration project, November 2008 to December 2013. Each system provided one intervention hospital and one control hospital.The control hospital in each system participated in pre- and postassessments but received no preassessment feedback and no intervention support...
May 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28459492/using-structured-option-test-questions-to-assess-competency-attainment-part-i
#19
Diane M Billings
Nursing is a practice profession, and nurse educators have the responsibility to ensure learner attainment of competency at all levels of nursing education. This two-part article provides basic information about designing structured-option test questions to assess and evaluate competency attainment. Part one discusses the uses, advantages, and limits of using structured-option test questions and explains how to develop a structured-option test question. Part two provides information about developing a test blueprint, administering the test, interpreting test results, and revising the test questions...
May 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28430919/non-coding-rnas-in-cardiovascular-diseases-diagnostic-and-therapeutic-perspectives
#20
Wolfgang Poller, Stefanie Dimmeler, Stephane Heymans, Tanja Zeller, Jan Haas, Mahir Karakas, David-Manuel Leistner, Philipp Jakob, Shinichi Nakagawa, Stefan Blankenberg, Stefan Engelhardt, Thomas Thum, Christian Weber, Benjamin Meder, Roger Hajjar, Ulf Landmesser
Recent research has demonstrated that the non-coding genome plays a key role in genetic programming and gene regulation during development as well as in health and cardiovascular disease. About 99% of the human genome do not encode proteins, but are transcriptionally active representing a broad spectrum of non-coding RNAs (ncRNAs) with important regulatory and structural functions. Non-coding RNAs have been identified as critical novel regulators of cardiovascular risk factors and cell functions and are thus important candidates to improve diagnostics and prognosis assessment...
April 18, 2017: European Heart Journal
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