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Blueprinting and assessment

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https://www.readbyqxmd.com/read/28609535/comparison-of-content-on-the-american-board-of-internal-medicine-maintenance-of-certification-examination-with-conditions-seen-in-practice-by-general-internists
#1
Bradley Gray, Jonathan Vandergrift, Rebecca S Lipner, Marianne M Green
Importance: Success on the internal medicine (IM) examination is a central requirement of the American Board of Internal Medicine's (ABIM's) Maintenance of Certification program (MOC). Therefore, it is important to understand the degree to which this examination reflects conditions seen in practice, one dimension of content validity, which focuses on the match between content in the discipline and the topics on the examination questions. Objective: To assess whether the frequency of questions on IM-MOC examinations were concordant with the frequency of conditions seen in practice...
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28581813/dominance-of-metric-correlations-in-two-dimensional-neuronal-cultures-described-through-a-random-field-ising-model
#2
Lluís Hernández-Navarro, Javier G Orlandi, Benedetta Cerruti, Eduard Vives, Jordi Soriano
We introduce a novel random field Ising model, grounded on experimental observations, to assess the importance of metric correlations in cortical circuits in vitro. Metric correlations arise from both the finite axonal length and the heterogeneity in the spatial arrangement of neurons. The experiments consider the response of neuronal cultures to an external electric stimulation for a gradually weaker connectivity strength between neurons, and in cultures with different spatial configurations. The model can be analytically solved in the metric-free, mean-field scenario...
May 19, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28581678/ttn-genotype-is-associated-with-fascicle-length-and-marathon-running-performance
#3
Georgina K Stebbings, Alun G Williams, Adam J Herbert, Sarah J Lockey, Shane M Heffernan, Robert M Erskine, Christopher I Morse, Stephen H Day
Titin provides a molecular blueprint for muscle sarcomere assembly and sarcomere length can vary according to titin isoform expression. If variations in sarcomere length influence muscle fascicle length, this may provide an advantage for running performance. Thus the aim of this study was to investigate if the titin (TTN) rs10497520 polymorphism was associated with muscle fascicle length in recreationally active men (RA; n = 137) and marathon personal best time in male marathon runners (MR; n = 141). Fascicle length of the vastus lateralis was assessed in vivo using B-mode ultrasonography at 50% of muscle length in RA...
June 5, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28477085/linking-of-the-quality-of-life-in-neurological-disorders-neuro-qol-to-the-international-classification-of-functioning-disability-and-health
#4
Alex W K Wong, Stephen C L Lau, David Cella, Jin-Shei Lai, Guanli Xie, Lidian Chen, Chetwyn C H Chan, Allen W Heinemann
BACKGROUND: The quality of life in neurological disorders (Neuro-QoL) is a U.S. National Institutes of Health initiative that produced a set of self-report measures of physical, mental, and social health experienced by adults or children who have a neurological condition or disorder. OBJECTIVE: To describe the content of the Neuro-QoL at the item level using the World Health Organization's international classification of functioning, disability and health (ICF)...
May 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28471853/blueprint-for-sustainable-change-in-diversity-management-and-cultural-competence-lessons-from-the-national-center-for-healthcare-leadership-diversity-demonstration-project
#5
Janice L Dreachslin, Robert Weech-Maldonado, Judith Gail, Josué Patien Epané, Joyce Anne Wainio
How can healthcare leaders build a sustainable infrastructure to leverage workforce diversity and deliver culturally and linguistically appropriate care to patients? To answer that question, two health systems participated in the National Center for Healthcare Leadership's diversity leadership demonstration project, November 2008 to December 2013. Each system provided one intervention hospital and one control hospital.The control hospital in each system participated in pre- and postassessments but received no preassessment feedback and no intervention support...
May 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28459492/using-structured-option-test-questions-to-assess-competency-attainment-part-i
#6
Diane M Billings
Nursing is a practice profession, and nurse educators have the responsibility to ensure learner attainment of competency at all levels of nursing education. This two-part article provides basic information about designing structured-option test questions to assess and evaluate competency attainment. Part one discusses the uses, advantages, and limits of using structured-option test questions and explains how to develop a structured-option test question. Part two provides information about developing a test blueprint, administering the test, interpreting test results, and revising the test questions...
May 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28430919/non-coding-rnas-in-cardiovascular-diseases-diagnostic-and-therapeutic-perspectives
#7
Wolfgang Poller, Stefanie Dimmeler, Stephane Heymans, Tanja Zeller, Jan Haas, Mahir Karakas, David-Manuel Leistner, Philipp Jakob, Shinichi Nakagawa, Stefan Blankenberg, Stefan Engelhardt, Thomas Thum, Christian Weber, Benjamin Meder, Roger Hajjar, Ulf Landmesser
Recent research has demonstrated that the non-coding genome plays a key role in genetic programming and gene regulation during development as well as in health and cardiovascular disease. About 99% of the human genome do not encode proteins, but are transcriptionally active representing a broad spectrum of non-coding RNAs (ncRNAs) with important regulatory and structural functions. Non-coding RNAs have been identified as critical novel regulators of cardiovascular risk factors and cell functions and are thus important candidates to improve diagnostics and prognosis assessment...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28418816/safe-and-competent-opioid-prescribing-education-increasing-dissemination-with-a-train-the-trainer-program
#8
Lara Zisblatt, Sean M Hayes, Patrice Lazure, Ilana Hardesty, Julie L White, Daniel P Alford
BACKGROUND: Due to the high prevalence of prescription opioid misuse, the US Food and Drug Administration (FDA) mandated a Risk Evaluation and Mitigation Strategy (REMS) requiring manufacturers of extended-release/long-acting (ER/LA) opioids to fund continuing education based on an FDA curricular Blueprint. This paper describes the Safe and Competent Opioid Prescribing Education (SCOPE of Pain) train-the-trainer program and its impact on (1) disseminating the SCOPE of Pain curriculum and (2) knowledge, confidence, attitudes, and performance of the participants of trainer-led compared with expert-led meetings...
April 2017: Substance Abuse
https://www.readbyqxmd.com/read/28394736/what-do-providers-want-to-know-about-opioid-prescribing-a-qualitative-analysis-of-their-questions
#9
Phoebe A Cushman, Jane M Liebschutz, Joseph G Hodgkin, Christopher W Shanahan, Julie L White, Ilana Hardesty, Daniel P Alford
BACKGROUND: In 2012, the US Food and Drug Administration (FDA) responded to the opioid crisis with a Risk Evaluation and Mitigation Strategy, requiring manufacturers of extended-release/long-acting opioids to fund continuing medical education based on the "FDA Blueprint for Prescriber Education." Topics in the Blueprint are "Assessing Patients for Treatment," "Initiating Therapy, Modifying Dosing, and Discontinuing Use," "Managing Therapy," "Counseling Patients and Caregivers about Safe Use," "General Drug Information," and "Specific Drug Information...
April 2017: Substance Abuse
https://www.readbyqxmd.com/read/28390401/a-process-evaluation-of-systematic-risk-and-needs-assessment-for-caregivers-in-specialised-palliative-care
#10
Kia Toft Thomsen, Mai-Britt Guldin, Mette Kjærgaard Nielsen, Chaitali Laura Ollars, Anders Bonde Jensen
BACKGROUND: Caregiving is strenuous and it may be associated with adverse psychological outcomes. During the palliative care trajectory, there are unique opportunities for providing support and preventing poor bereavement outcome. However, the tasks of palliative care staff in relation to caregivers are often unclear in the daily practice. Assessment is recommended to establish risk and needs and standards for caregiver support are available. Still, the feasibility of applying these standards among caregivers in everyday clinical practice has not been tested so far...
April 8, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28346606/evidence-based-redesign-of-the-comlex-usa-series
#11
John R Gimpel, Dorothy Horber, Jeanne M Sandella, Janice A Knebl, John E Thornburg
To ensure that the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) reflects the evolving practice of osteopathic medicine, the National Board of Osteopathic Medical Examiners has developed new content and format specifications for an enhanced, competency-based examination program to be implemented with COMLEX-USA Level 3 in 2018. This article summarizes the evidence-based design processes that served as the foundation for blueprint development and the evidence supporting its validity...
April 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28280833/improving-the-capacity-of-lithium-sulfur-batteries-by-tailoring-the-polysulfide-adsorption-efficiency-of-hierarchical-oxygen-nitrogen-functionalized-carbon-host-materials
#12
Artur Schneider, Jürgen Janek, Torsten Brezesinski
The use of monolithic carbons with structural hierarchy and varying amounts of nitrogen and oxygen functionalities as sulfur host materials in high-loading lithium-sulfur cells is reported. The primary focus is on the strength of the polysulfide/carbon interaction with the goal of assessing the effect of (surface) dopant concentration on cathode performance. The adsorption capacity - which is a measure of the interaction strength between the intermediate lithium polysulfide species and the carbon - was found to scale almost linearly with the nitrogen level...
March 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28237205/value-assessment-frameworks-for-hta-agencies-the-organization-of-evidence-informed-deliberative-processes
#13
Rob Baltussen, Maarten Paul Maria Jansen, Leon Bijlmakers, Janneke Grutters, Anouck Kluytmans, Rob P Reuzel, Marcia Tummers, Gert Jan van der Wilt
Priority setting in health care has been long recognized as an intrinsically complex and value-laden process. Yet, health technology assessment agencies (HTAs) presently employ value assessment frameworks that are ill fitted to capture the range and diversity of stakeholder values and thereby risk compromising the legitimacy of their recommendations. We propose "evidence-informed deliberative processes" as an alternative framework with the aim to enhance this legitimacy. This framework integrates two increasingly popular and complementary frameworks for priority setting: multicriteria decision analysis and accountability for reasonableness...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28220022/using-metaphors-to-explain-molecular-testing-to-cancer-patients
#14
Ana P M Pinheiro, Rachel H Pocock, Margie D Dixon, Walid L Shaib, Suresh S Ramalingam, Rebecca D Pentz
BACKGROUND: Molecular testing to identify targetable molecular alterations is routine practice for several types of cancer. Explaining the underlying molecular concepts can be difficult, and metaphors historically have been used in medicine to provide a common language between physicians and patients. Although previous studies have highlighted the use and effectiveness of metaphors to help explain germline genetic concepts to the general public, this study is the first to describe the use of metaphors to explain molecular testing to cancer patients in the clinical setting...
April 2017: Oncologist
https://www.readbyqxmd.com/read/28202633/regional-changes-in-cns-and-retinal-glycerophospholipid-profiles-with-age-a-molecular-blueprint
#15
Blake R Hopiavuori, Martin-Paul Agbaga, Richard S Brush, Michael T Sullivan, William E Sonntag, Robert E Anderson
We present here a quantitative molecular blueprint of the three major glycerophospholipid (GPL) classes, phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE), in retina and six regions of the brain in C57Bl6 mice at 2, 10, and 26 months of age. We found an age-related increase in molecular species containing saturated and monoenoic FAs and an overall decrease in the longer-chain PUFA molecular species across brain regions, with loss of DHA-containing molecular species as the most consistent and dramatic finding...
April 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28089342/a-simulation-based-cognitive-assessment-of-resident-decision-making-during-complex-urinary-catheterization-scenarios
#16
Jay N Nathwani, Katherine E Law, Anna K Witt, R D Ray, S M DiMarco, C M Pugh
BACKGROUND: This study explores general surgery residents' decision making skills in uncommon, complex urinary catheter scenarios. METHODS: 40 residents were presented with two scenarios. Scenario A was a male with traumatic urethral injury and scenario B was a male with complete urinary blockage. Residents verbalized whether they would catheterize the patient and described the workup and management of suspected pathologies. Residents' decision paths were documented and analyzed...
April 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28078793/insights-into-nuclear-dynamics-using-live-cell-imaging-approaches
#17
REVIEW
Rachel B Bigley, Alexander Y Payumo, Jeffrey M Alexander, Guo N Huang
The nucleus contains the genetic blueprint of the cell and myriad interactions within this subcellular structure are required for gene regulation. In the current scientific era, characterization of these gene regulatory networks through biochemical techniques coupled with systems-wide 'omic' approaches has become commonplace. However, these strategies are limited because they represent a mere snapshot of the cellular state. To obtain a holistic understanding of nuclear dynamics, relevant molecules must be studied in their native contexts in living systems...
March 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28032665/a-blueprint-for-full-collective-flood-risk-estimation-demonstration-for-european-river-flooding
#18
Francesco Serinaldi, Chris G Kilsby
Floods are a natural hazard evolving in space and time according to meteorological and river basin dynamics, so that a single flood event can affect different regions over the event duration. This physical mechanism introduces spatio-temporal relationships between flood records and losses at different locations over a given time window that should be taken into account for an effective assessment of the collective flood risk. However, since extreme floods are rare events, the limited number of historical records usually prevents a reliable frequency analysis...
December 29, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28003895/perceptions-of-the-use-of-blueprinting-in-a-formative-theory-assessment-in-pharmacology-education
#19
Tejas Patel, Manoj K Saurabh, Parvati Patel
OBJECTIVES: This study aimed to assess perceptions of the use of a blueprint in a pharmacology formative theory assessment. METHODS: This study took place from October 2015 to February 2016 at a medical college in Gujurat, India. Faculty from the Department of Pharmacology used an internal syllabus to prepare an assessment blueprint. A total of 12 faculty members prepared learning objectives and categorised cognitive domain levels by consensus. Learning objectives were scored according to clinical importance and marks were distributed according to proportional weighting...
November 2016: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/27956747/acute-engagement-of-gq-mediated-signaling-in-the-bed-nucleus-of-the-stria-terminalis-induces-anxiety-like-behavior
#20
C M Mazzone, D Pati, M Michaelides, J DiBerto, J H Fox, G Tipton, C Anderson, K Duffy, J M McKlveen, J A Hardaway, S T Magness, W A Falls, S E Hammack, Z A McElligott, Y L Hurd, T L Kash
The bed nucleus of the stria terminalis (BNST) is a brain region important for regulating anxiety-related behavior in both humans and rodents. Here we used a chemogenetic strategy to investigate how engagement of G protein-coupled receptor (GPCR) signaling cascades in genetically defined GABAergic BNST neurons modulates anxiety-related behavior and downstream circuit function. We saw that stimulation of vesicular γ-aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using hM3Dq, but neither hM4Di nor rM3Ds designer receptors exclusively activated by a designer drug (DREADD), promotes anxiety-like behavior...
December 13, 2016: Molecular Psychiatry
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