keyword
MENU ▼
Read by QxMD icon Read
search

Simulation and assessment

keyword
https://www.readbyqxmd.com/read/29045825/cerenkov-luminescence-imaging-on-evaluation-of-early-response-to-chemotherapy-of-drug-resistant-gastric-cancer
#1
Muhan Liu, Sheng Zheng, Xiaojun Zhang, Hongbo Guo, Xiaojing Shi, Xiaoyu Kang, Yawei Qu, Zhenhua Hu, Jie Tian
Apoptosis imaging enables a timely and specific assessment of treatment response in cancer patients. In this study, we applied a probe for positron emission tomography (PET), served as an optical biomaterial emitting Cerenkov photons, to in vivo optical imaging of tumor apoptosis, in order to evaluate early response to chemotherapy of drug-resistant gastric cancer. (68)Ga-DOTA-Annexin V was prepared as the apoptosis targeting probe. Wild type human gastric adenocarcinoma cell line SGC7901/WT and drug vincristine-resistant variant SGC7901/VCR were used to establish normal and vincristine-resistant xenograft to simulate treatment decision situation...
October 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29044791/the-role-of-driving-factors-in-historical-and-projected-carbon-dynamics-of-upland-ecosystems-in-alaska
#2
Hélène Genet, Yujie He, Zhou Lyu, A David McGuire, Qianlai Zhuang, Joy Clein, David D'Amore, Alec Bennett, Amy Breen, Frances Biles, Eugénie S Euskirchen, Kristofer Johnson, Tom Kurkowski, Svetlana Kushch Schroder, Neal Pastick, T Scott Rupp, Bruce Wylie, Yujin Zhang, Xiaoping Zhou, Zhiliang Zhu
It is important to understand how upland ecosystems of Alaska, which are estimated to occupy 84% of the state (i.e. 1,237,774 km(2) ), are influencing and will influence state-wide carbon (C) dynamics in the face of ongoing climate change. We coupled fire disturbance and biogeochemical models to assess the relative effects of changing atmospheric carbon dioxide (CO2 ), climate, logging and fire regimes on the historical and future C balance of upland ecosystems for the four main Landscape Conservation Cooperatives (LCCs) of Alaska...
October 17, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29044673/modeling-the-effects-of-thiamethoxam-on-midwestern-farm-ponds-and-emergent-wetlands
#3
Steven M Bartell, Shyam K Nair, Shanique Grant, Richard A Brain
Potential toxic effects of thiamethoxam (TMX) on non-target organisms and community structure of a generic Midwestern farm pond and emergent wetland were assessed using two versions of the Comprehensive Aquatic System Model, the CASMGFP - a generic farm pond model, and the CASMGWL - a generic wetland model. The CASMGFP and CASMGWL are integrated bioenergetics-based and habitat quality models that describe the daily biomass values of selected producer and consumer populations representative of generalized Midwestern farm ponds and emergent wetlands...
October 18, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29044127/engineered-in-vitro-cell-line-mixtures-and-robust-evaluation-of-computational-methods-for-clonal-decomposition-and-longitudinal-dynamics-in-cancer
#4
Hossein Farahani, Camila P E de Souza, Raewyn Billings, Damian Yap, Karey Shumansky, Adrian Wan, Daniel Lai, Anne-Marie Mes-Masson, Samuel Aparicio, Sohrab P Shah
Characterization and quantification of tumour clonal populations over time via longitudinal sampling are essential components in understanding and predicting the response to therapeutic interventions. Computational methods for inferring tumour clonal composition from deep-targeted sequencing data are ubiquitous, however due to the lack of a ground truth biological data, evaluating their performance is difficult. In this work, we generate a benchmark data set that simulates tumour longitudinal growth and heterogeneity by in vitro mixing of cancer cell lines with known proportions...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043804/proton-assisted-recoupling-par-in-peptides-and-proteins
#5
Kevin J Donovan, Sheetal K Jain, Robert Silvers, Sara Linse, Robert G Griffin
Proton assisted recoupling (PAR) is examined by exploring optimal experimental conditions and magnetization transfer rates in a variety of biologically relevant nuclear spin-systems including simple amino acids, model peptides and two proteins - nanocrystalline protein G (GB1), and importantly amyloid beta 1-42 (M0Aβ1-42) fibrils. A selective PAR protocol, SUBPAR (Setting Up Better Proton Assisted Recoupling), is described to observe magnetization transfer in one-dimensional spectra, which minimizes experiment time (in comparison to 2D experiments) and thereby enables an efficient assessment of optimal PAR conditions for a desired magnetization transfer...
October 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29043555/impact-of-non-specific-normal-databases-on-perfusion-quantification-of-low-dose-myocardial-spect-studies
#6
Camilla Scabbio, Orazio Zoccarato, Simona Malaspina, Giovanni Lucignani, Angelo Del Sole, Michela Lecchi
AIM: To evaluate the impact of non-specific normal databases on the percent summed rest score (SR%) and stress score (SS%) from simulated low-dose SPECT studies by shortening the acquisition time/projection. METHODS: Forty normal-weight and 40 overweight/obese patients underwent myocardial studies with a conventional gamma-camera (BrightView, Philips) using three different acquisition times/projection: 30, 15, and 8 s (100%-counts, 50%-counts, and 25%-counts scan, respectively) and reconstructed using the iterative algorithm with resolution recovery (IRR) Astonish(TM) (Philips)...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29042953/oral-colon-specific-drug-delivery-system-reduces-the-nephrotoxicity-of-rhubarb-anthraquinones-when-they-produce-purgative-efficacy
#7
Pei Liu, Hongwei Wei, Jinhua Chang, Guangxin Miao, Xigang Liu, Zhongsi Li, Liyan Liu, Xiangrong Zhang, Cuizhe Liu
Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) were prepared to determine whether RTFA-OCDD-GN could reduce the nephrotoxicity that occurs when AQs produce purgative efficacy. RTFA-OCDD-GN were prepared using pH-enzyme double-layer coating technology and the cumulative release rate of RTFA in RTFA-OCDD-GN was assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042467/variability-in-heart-to-mediastinum-ratio-from-planar-123-i-mibg-images-of-a-thorax-phantom-for-6-common-gamma-camera-models
#8
Rikard Owenius, Michelle Zanette, Patrick Cella
A heart-to-mediastinum (H/M) ratio ≥1.6 on planar Iobenguane (123)I ((123)I-mIBG; AdreView) images identifies heart failure patients at low risk of experiencing an adverse cardiac event. This phase 4 study used standardized phantoms to assess the inter-camera, intra-camera, and inter-head variability in H/M ratio determinations from planar cardiac (123)I-mIBG imaging using commercially-available, dual-head gamma cameras. Methods: A fillable thorax phantom was developed to simulate the typical uptake of (123)I-mIBG...
October 17, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29042171/development-of-a-computerized-adaptive-testing-system-of-the-functional-assessment-of-stroke
#9
Gong-Hong Lin, Yi-Jing Huang, Shih-Chieh Lee, Sheau-Ling Huang, Ching-Lin Hsieh
OBJECTIVE: To develop a computerized adaptive testing system of the Functional Assessment of Stroke (CAT-FAS) to assess upper- and lower-extremity (UE/LE) motor function, postural control, and basic activities of daily living (BADL) with optimal efficiency and without sacrificing psychometric properties in patients with stroke. DESIGN: Simulation study using the data from a previous study. Participants were assessed with the UE/LE subscales of the Fugl-Meyer Assessment (UE-FM/LE-FM), Postural Assessment Scale for Stroke patients (PASS), and Barthel Index (BI) at 14- and 30-day after stroke...
October 14, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29042115/effect-of-thickness-and-surface-modifications-on-flexural-strength-of-monolithic-zirconia
#10
Fusun Ozer, Andrew Naden, Volkan Turp, Francis Mante, Deniz Sen, Markus B Blatz
STATEMENT OF PROBLEM: A recommended minimum thickness for monolithic zirconia restorations has not been reported. Assessing a proper thickness that has the necessary load-bearing capacity but also conserves dental hard tissues is essential. PURPOSE: The purpose of this in vitro study was to evaluate the effect of thickness and surface modifications on monolithic zirconia after simulated masticatory stresses. MATERIAL AND METHODS: Monolithic zirconia disks (10 mm in diameter) were fabricated with 1...
October 14, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29042056/a-computational-model-of-the-hepatic-circulation-applied-to-analyze-the-sensitivity-of-hepatic-venous-pressure-gradient-hvpg-in-liver-cirrhosis
#11
Tianqi Wang, Fuyou Liang, Zunqiang Zhou, Lu Shi
Measurement of hepatic venous pressure gradient (HVPG) is currently widely adopted to provide an estimate of portal pressure gradient (PPG) in the diagnosis and treatment of portal hypertension associated with liver cirrhosis. Despite the well-documented clinical utility of HVPG, it remains poorly understood how the relationship between HVPG and PPG is affected by factors involved in the pathogenesis and progression of cirrhosis. In the study, a computational model of the hepatic circulation calibrated to in vivo data was developed to simulate the procedure of HVPG measurement and quantitatively investigate the error of HVPG relative to PPG under various pathophysiological conditions...
October 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29042033/serious-game-training-improves-performance-in-combat-life-saving-interventions
#12
Jerome Planchon, Anthony Vacher, Jeremy Comblet, Eric Rabatel, Françoise Darses, Alexandre Mignon, Pierre Pasquier
AIM: In modern warfare, almost 25% of combat-related deaths are considered preventable if life-saving interventions are performed. Therefore, Tactical Combat Casualty Care (TCCC) training for soldiers is a major challenge. In 2014, the French Military Medical Service supported the development of 3D-SC1(®), a serious game designed for the French TCCC program, entitled Sauvetage au Combat de niveau 1 (SC1). Our study aimed to evaluate the impact on performance of additional training with 3D-SC1(®)...
October 12, 2017: Injury
https://www.readbyqxmd.com/read/29041994/hospital-surge-capacity-a-web-based-simulation-tool-for-emergency-planners
#13
Matthew F Toerper, Gabor D Kelen, Lauren M Sauer, Jamil D Bayram, Christina Catlett, Scott Levin
The National Center for the Study of Preparedness and Catastrophic Event Response (PACER) has created a publicly available simulation tool called Surge (accessible at http://www.pacerapps.org) to estimate surge capacity for user-defined hospitals. Based on user input, a Monte Carlo simulation algorithm forecasts available hospital bed capacity over a 7-day period and iteratively assesses the ability to accommodate disaster patients. Currently, the tool can simulate bed capacity for acute mass casualty events (such as explosions) only and does not specifically simulate staff and supply inventory...
October 18, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29041640/fiber-optic-mechanical-deformation-sensors-employing-perpendicular-photonic-crystals
#14
Roxana-Mariana Beiu, Valeriu Beiu, Virgil-Florin Duma
Existing fiber optics (FOs)-based sensors, including mechanical deformation ones rely on structures embedded along the length of the FO. In this paper, we introduce and evaluate photonic crystals (PCs) embedded into FO cores acting as mechanical deformation sensors which are departing from this classical approach as the PCs are perpendicular to the length of the FO. Another noteworthy difference from classical FO-PC based sensors is that while classical ones rely on amplitude variations, the ones presented here use the phase variations of the electromagnetic components for assessing mechanical deformations...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29040800/ocriplasmin-for-symptomatic-vitreomacular-adhesion
#15
REVIEW
James E Neffendorf, Varo Kirthi, Edward Pringle, Timothy L Jackson
BACKGROUND: Symptomatic vitreomacular adhesion (sVMA) is a recognised cause of visual loss and by tradition has been managed by pars plana vitrectomy (PPV). A less invasive alternative to surgery in some people is enzymatic vitreolysis, using an intravitreal injection of ocriplasmin. OBJECTIVES: To assess the efficacy and safety of ocriplasmin compared to no treatment, sham or placebo for the treatment of sVMA. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 1), MEDLINE Ovid (1946 to 24 February 2017), Embase Ovid (1947 to 24 February 2017), PubMed (1946 to 24 February 2017), the ISRCTN registry (www...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29040799/winter-survival-of-scots-pine-seedlings-under-different-snow-conditions
#16
Timo Domisch, Françoise Martz, Tapani Repo, Pasi Rautio
Future climate scenarios predict increased air temperatures and precipitation, particularly at high latitudes, and especially so during winter. Soil temperatures, however, are more difficult to predict, since they depend strongly on the fate of the insulating snow cover. 'Rain-on-snow' events and warm spells during winter can lead to thaw-freeze cycles, compacted snow and ice encasement, as well as local flooding. These adverse conditions could counteract the otherwise positive effects of climatic changes on forest seedling growth...
October 10, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29040787/why-size-matters-the-interactive-influences-of-tree-diameter-distribution-and-sap-flow-parameters-on-upscaled-transpiration
#17
Z Carter Berry, Nathaniel Looker, Friso Holwerda, León Rodrigo Gómez Aguilar, Perla Ortiz Colin, Teresa González Martínez, Heidi Asbjornsen
In stands with a broad range of diameters, a small number of very large trees can disproportionately influence stand basal area and transpiration (Et). Sap flow-based Et estimates may be particularly sensitive to large trees due to nonlinear relationships between tree-level water use (Q) and tree diameter at breast height (DBH). Because Q is typically predicted on the basis of DBH and sap flow rates measured in a subset of trees and then summed to obtain Et, we assessed the relative importance of DBH and sap flow variables (sap velocity, Vs, and sapwood depth, Rs) in determining the magnitude of Et and its dependence on large trees in a tropical montane forest ecosystem...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29040374/beyond-similarity-assessment-selecting-the-optimal-model-for-sequence-alignment-via-the-factorized-asymptotic-bayesian-algorithm
#18
Taikai Takeda, Michiaki Hamada
Motivation: Pair Hidden Markov Models (PHMMs) are probabilistic models used for pairwise sequence alignment, a quintessential problem in bioinformatics. PHMMs include three types of hidden states: match, insertion and deletion. Most previous studies have used one or two hidden states for each PHMM state type. However, few studies have examined the number of states suitable for representing sequence data or improving alignment accuracy. Results: We developed a novel method to select superior models (including the number of hidden states) for PHMM...
October 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040367/forehead-lift-using-botulinum-toxin
#19
Sarit Cohen, Ofir Artzi, Lior Heller
Background: The principle of dynamic muscular activity affecting eyebrow height and shape is well known. We postulate that similarly, dynamics of the fronto-galea-occipital muscles affect forehead height. Objectives: To present a forehead lift technique using Botulinum toxin injection and evaluate its clinical efficacy and safety. Methods: Twenty-nine female patients comprised the study group. Forty units of prepared abobutolinumtoxinA (Dysport, 10 U/0...
October 10, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040302/an-investigation-of-perceived-vehicle-speed-from-a-driver-s-perspective
#20
Changxu Wu, Dekuang Yu, Amy Doherty, Tianyi Zhang, Leo Kust, Gang Luo
PURPOSE: Speed estimation of drivers' own vehicles and other vehicles on the road is an important task for drivers and is also crucial to the roadway safety. The objective of the study was to examine the effects of multiple factors such as image scale, speed, road type, driving experience, and gender on the speed perception of drivers' own vehicles. METHODS: Thirty participants consisted of 17 males and 13 females, including 13 without driving experience. All participants estimated the driving speed of 192 5-second video clips, which were selected from naturalistic driving recordings...
2017: PloS One
keyword
keyword
42890
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"