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https://www.readbyqxmd.com/read/29455359/eosinophilic-esophagitis-an-important-comorbid-condition-of-asthma
#1
REVIEW
Sandy R Durrani, Vincent A Mukkada, Theresa W Guilbert
Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically...
February 18, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29445888/addressing-molecular-diagnosis-of-occupational-allergies
#2
REVIEW
Monika Raulf, Santiago Quirce, Olivier Vandenplas
PURPOSE OF REVIEW: Numerous clinically relevant allergenic molecules enhance the performance of specific (s) IgE tests and improve the specificity of allergy diagnosis. This review aimed to summarize our current knowledge of the high-molecular-weight allergens involved in the development of occupational asthma and rhinitis and to critically analyze the contribution of component-resolved diagnosis in the management of these conditions. RECENT FINDINGS: There is a lack of standardization and validation for most available extracts of occupational agents, and assessment of sIgE reactivity to occupational allergen components has been poorly investigated, with the notable exception of natural rubber latex (NRL) and wheat flour...
February 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#3
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29433423/microrna-17-5p-aggravates-lipopolysaccharide-induced-injury-in-nasal-epithelial-cells-by-targeting-smad7
#4
Nan Huang, Wenjing Li, Xiaolong Wang, Shanshan Qi
BACKGROUND: Globally, rhinitis is one of the most common chronic disorders. Despite availability of drugs to manage the symptomatology of rhinitis, researchers still focus on identification of novel molecular targets for better management. MicroRNAs are implicated in many biological and pathological processes. However, the role of miR-17-5p in rhinitis remains unexplored. This study aimed to explore the role of miR-17-5p in lipopolysaccharide (LPS)-induced injury of nasal epithelial RPMI2650 cells and to elucidate the possible underlying molecular mechanism...
February 13, 2018: BMC Cell Biology
https://www.readbyqxmd.com/read/29423374/the-international-study-of-the-allergic-rhinitis-survey-outcomes-from-4-geographical-regions
#5
Desiderio Passali, Cemal Cingi, Paola Staffa, Francesco Passali, Nuray Bayar Muluk, Maria Luisa Bellussi
Background: Allergic rhinitis (AR) is a global health problem and is characterised by one or more symptoms, including sneezing, itching, nasal congestion and rhinorrhea. Objective: We investigated the features of AR and the physician's approach to the management of AR patients in four geographical regions. Methods: In this cross-sectional study, a questionnaire survey concerning AR was completed by Honorary and Corresponding Members of the Italian Society of Rhinology from different countries among 4 world geographical regions-Asia, Europe, the Americas, and Africa...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29416367/profile-of-dupilumab-and-its-potential-in-the-treatment-of-inadequately-controlled-moderate-to-severe-atopic-dermatitis
#6
REVIEW
Olabola Awosika, Lori Kim, Momina Mazhar, Monica Rengifo-Pardo, Alison Ehrlich
Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma. Historically, moderate-to-severe disease has been managed with systemic immunosuppression, such as oral corticosteroids, which result in relapse and limiting side effects. Due to recent advancements in the identification of interleukin (IL)-4 and IL-13 as key mediators in AD, new biological agents have been developed for treatment. Dupilumab is a recently approved monoclonal antibody that targets the alpha subunit of the IL-4 receptor and, thus, downregulates activity of IL-4 and IL-13...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29406839/allergic-rhinitis-management-what-s-next
#7
Farnaz Tabatabaian, Thomas B Casale
Allergic rhinitis (AR) is characterized by the presence of congestion, postnasal drainage, sneezing and rhinorrhea. AR contributes to reduced productivity and significant morbidity worldwide. Areas Covered: We review data emphasizing that the most effective therapy to alter the course of AR is allergen-specific immunotherapy, either subcutaneous or sublingual. However, significant advancements in developing alternative forms of therapies have opened the door for potential novel avenues of treating patients with AR...
February 6, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29397373/the-journal-of-allergy-and-clinical-immunology-in%C3%A2-practice-2017-year-in-review
#8
REVIEW
Michael Schatz, Scott H Sicherer, Robert S Zeiger
An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29375890/field-evaluation-of-piglet-vaccination-with-a-mycoplasma-hyopneumoniae-bacterin-as-compared-to-a-ready-to-use-product-including-porcine-circovirus-2-and-m-hyopneumoniae-in-a-conventional-french-farrow-to-finish-farm
#9
Didier Duivon, Isabelle Corrégé, Anne Hémonic, Martial Rigaut, David Roudaut, Rika Jolie
Background: A controlled randomized trial was performed on a well-managed conventional French 180-sow farm. The trial compared the growth performances of piglets vaccinated at weaning (single shot) either with a commercial monovalent Mycoplasma hyopneumoniae bacterin vaccine or with a commercial bivalent vaccine (Porcilis® PCV M Hyo) against M. hyopneumoniae and porcine circovirus 2 (PCV2). The farm's porcine reproductive and respiratory syndrome status was stable, and most diseases (enzootic pneumonia, atrophic rhinitis, post-weaning multisystemic wasting syndrome) were controlled by routine vaccination...
2018: Porcine Health Management
https://www.readbyqxmd.com/read/29362452/tell-me-about-your-hay-fever-a-qualitative-investigation-of-allergic-rhinitis-management-from-the-perspective-of-the-patient
#10
Biljana Cvetkovski, Vicky Kritikos, Kwok Yan, Sinthia Bosnic-Anticevich
Allergic rhinitis (AR) is sub-optimally managed in the community and is responsible for a significant health and economic burden. Uncontrolled AR increases the risk of poorly controlled asthma and presents an increased susceptibility to thunderstorm asthma. With the availability of treatments over-the-counter, bypassing the health care professional (HCP), the role of the patient is paramount. Research on the role of the patient in AR management in the current environment is limited. This study aims to explore the patient perspective of AR management and understand why it is sub-optimally managed in the community...
January 23, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29350019/cypress-pollen-allergy-is-responsible-for-two-distinct-phenotypes-of-allergic-rhinitis-different-from-other-pollinosis
#11
L Pahus, M Gouitaa, T Sofalvi, K Alagha, D Gras, P Chanez, D Charpin
Different phenotypes of allergic rhinitis have been identified based on the seasonality of the allergen involved. Within pollinosis, importance has to be paid to the responsible pollen species. Guidelines for clinical management are mostly based on studies performed in patients with grass pollen allergy. Only few data is available on tree pollen allergy and more specifically on cypress pollen allergy. We focused on the clinical and biological features of cypress pollen allergy to determine whether it is associated with a specific phenotype of allergic rhinitis or not...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350016/biomarkers-of-treatment-efficacy-in-patients-with-chronic-spontaneous-urticaria
#12
M Sánchez-Borges, A Capriles-Hulett, F Caballero-Fonseca, L González-Aveledo
Background. Currently there are no biomarkers useful to predict the future evolution and the therapeutic response in patients with chronic spontaneous urticaria (CSU). Objective. To review the available information on biomarkers that might be applied for the follow up of the response to guideline recommended therapies for CSU. Methods. A review of the medical literature on CSU potential clinical and laboratory biomarkers in PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria, antihistamines (AHs), omalizumab (OMA), cyclosporine (CyA), and treatment...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29317281/an-assessment-of-the-use-of-antihistamines-in-the-management-of-atopic-dermatitis
#13
Alice He, Steven R Feldman, Alan B Fleischer
BACKGROUND: Antihistamines are often used to treat pruritus associated with atopic dermatitis (AD) despite lack of evidence for their efficacy. The American Academy of Dermatology does not recommend the general use of antihistamines in the management of AD, although the value of short-term sedating antihistamine use for insomnia secondary to itch is recognized. OBJECTIVE: To assess the use of sedating and non-sedating antihistamines for AD from 2003-2012. METHODS: The National Ambulatory Medical Care Survey (NAMCS) provided data on physician visits from 2003-2012...
January 6, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29313309/air-pollution-and-allergic-airway-diseases-social-determinantsand-sustainability-in-the-control-and-prevention
#14
REVIEW
H Paramesh
Air pollution, global warming and climate change are the major contributing factors in causing the increase prevalence of allergic airway diseases like asthma and allergic rhinitis and they will be the defining issues for health system in the twenty-first century. Asthma is an early onset non-communicable environmental disease with global epidemic and contributes a greatest psycho socio economic burden. Nearly 8 million global deaths are from air pollution. Over one billion population are the sufferers during 2015 and will increase to 4 billion by 2050...
January 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29284253/risk-factors-for-work-related-eczema-and-urticaria-among-vocational-students-of-agriculture
#15
Radosław Śpiewak, Anna Góra-Florek, Andrzej Horoch, Mirosław J Jarosz, Agnieszka Doryńska, Marcin Golec, Jacek Dutkiewicz
INTRODUCTION AND OBJECTIVE: Farmers are at high risk of occupational skin diseases which may start already during vocational training. This study was aimed at identification of risk factors for work-related skin diseases among vocational students of agriculture. MATERIAL AND METHODS: The study involved 440 students (245 males, 195 females aged 17-21 years) in 11 vocational schools which were at least 100 km from each other. The protocol included a physician-managed questionnaire and medical examination, skin prick tests, patch tests, total IgE and Phadiatop...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29260784/-the-role-of-local-immunotherapy-in-the-treatment-of-the-patients-presenting-with-virus-associated-allergic-rhinitis
#16
N S Tataurshchikova, B Sangidorzh
The objective of the present study was to evaluate the clinical effectiveness of intranasal immunotherapy with the use of сycloferon in the patients presenting with seasonal virus-associated allergic rhinitis during the period of pollination. The results of the treatment of 50 patients with virus-associated allergic rhinitis (i.e. those allergic to the sagebrush pollen) were analyzed. The patients were divided into two groups depending on the therapeutic modality being used. Those comprising the main group (21 patients) received immunotherapy with сycloferon in addition to allergen-specific immunotherapy (by sublingual administration)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29229090/health-related-quality-of-life-in-asthma-patients-a-comparison-of-two-cohorts-from-2005-and-2015
#17
Josefin Sundh, Philip Wireklint, Mikael Hasselgren, Scott Montgomery, Björn Ställberg, Karin Lisspers, Christer Janson
INTRODUCTION: The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. MATERIAL AND METHODS: Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t-test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29223720/serum-periostin-is-associated-with-body-mass-index-and-allergic-rhinitis-in-healthy-and-asthmatic-subjects
#18
Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Katsunori Shigehara, Junya Ono, Kenji Izuhara, Yoichi Minagawa Ito, Masaharu Nishimura
BACKGROUND: Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. We also assessed some factors in asthmatic subjects to confirm their extrapolation for management of asthma...
December 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29221328/uncontrolled-and-under-diagnosed-asthma-in-a-damascus-shelter-during-the-syrian-crisis
#19
Yousser Mohammad, Shaaban Rafea, Youssef Latifeh, Ali Khaddam, Bisher Sawaf, Mhd Ismael Zakaria, Mohammad Sadek Al Masalmeh, Yaser Fawaz, Abdoulraouf Allaham, Imad Almani, Hiba El-Tarcheh, Ayham Ghazal, Ali Zaher, Hala Rifai, Hamed Joumah, S Dresden Glockler-Lauf, Teresa To
Background: Studies have shown that poor shelter or dwelling conditions may lead to deteriorations in health. Those with asthma may be more susceptible to compromised living conditions and stress leading to a higher risk of asthma exacerbations. To describe the asthma control and quality of life of individuals with diagnosed asthma living in a shelter in Damascus, Syria and estimate the prevalence of respiratory symptoms in shelter dwellers without diagnosed asthma. Methods: In this cross-sectional study, all individuals 5 years and older living in Al-Herjalleh shelter with diagnosed asthma were recruited to complete a questionnaire, which included items related to their respiratory symptoms, asthma exacerbations, exposure to asthma triggers, medication use, and health-related quality of life before and since entering the shelter...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29202563/topical-hyaluronic-acid-in-rhinitis-medicamentosa-could-our-perspective-be-changed
#20
M Casale, P Vella, A Moffa, L Sabatino, V Rinaldi, V Grimaldi, F Salvinelli
This study was designed to prospectively evaluate the role of nebulized hyaluronic acid (HA) administered for 10 days as treatment for patients with rhinitis medicamentosa (RM). RM is a pathological condition of the nasal mucosa induced by prolonged, excessive or improper use of topical decongestants. It is characterized by persistent nasal congestion that can lead the patient to increase the frequency of application and the quantity of the substance being applied, resulting in dependence on topical nasal decongestants...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
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