Sepideh Karkon-Shayan, Hasan Aliashrafzadeh, Hassan Dianat-Moghadam, Nima Rastegar-Pouyani, Mohammadreza Majidi, Mahdi Zarei, Sadegh Moradi-Vastegani, Yaser Bahramvand, Sepideh Babaniamansour, Emad Jafarzadeh
Glioblastoma multiforme (GBM) is one of the most aggressive brain and spinal cord tumors. Despite the significant development in application of antitumor drugs, no significant increases have been observed in the survival rates of patients with GBM, as GBM cells acquire resistance to conventional anticancer therapeutic agents. Multiple studies have revealed that PI3K/Akt, MAPK, Nanog, STAT 3, and Wnt signaling pathways are involved in GBM progression and invasion. Besides, biological processes such as anti-apoptosis, autophagy, angiogenesis, and stemness promote GBM malignancy...
June 17, 2023: Acta Histochemica