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https://www.readbyqxmd.com/read/28611074/cervical-spinal-glioblastoma-multiforme-in-the-elderly
#1
Dmitri Shastin, Ryan K Mathew, Azzam Ismail, Gerry Towns
Spinal glioblastoma multiforme (GBM) is uncommon, and its diagnosis may be challenging. This is especially true in the elderly population. Best management strategy remains to be defined. The purpose of this report is to document this rare condition, increase awareness (as a potential differential diagnosis) and propose treatment options in the elderly; a review of the relevant literature is included. A biopsy may be beneficial in given circumstances as cervical spinal GBM carries a better prognosis compared with intramedullary metastasis...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28512411/spinal-intradural-intramedullary-dissemination-in-the-absence-of-intracranial-relapse-of-a-previously-radically-treated-temporal-lobe-glioblastoma-multiforme
#2
Lucas Serrano, Eleftherios Archavlis, Elke Januschek, Pavel Timofeev, Peter Ulrich
Intracranial glioblastoma multiforme (GBM) constitutes the most frequent and unfortunately aggressive primary central nervous system malignancy. Despite the high tendency of these tumors to show local relapse within the brain after primary therapy, dissemination into the spinal axis is an infrequent event. If spinal metastases occur they are leptomeningeal in the vast majority of cases and always in the context of intracranial progressive disease. Spinal intramedullary metastases of intracranial GBM have rarely been described to date...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28422860/primary-spinal-glioblastoma-multiforme-a-case-report-and-review-of-the-literature
#3
Chao-Xiong Shen, Jian-Feng Wu, Wei Zhao, Zhao-Wen Cai, Ran-Ze Cai, Chun-Mei Chen
RATIONALE: Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases. PATIENT CONCERNS: A 15-year-old female was admitted to the neurology department with a chief complaint of progressive numbness and weakness in her left upper extremity for 3 months and neck pain for 1 month...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28377242/primary-spinal-cord-glioblastoma-multiforme-a-retrospective-study-of-patients-at-a-single-institution
#4
Xing Cheng, Silong Lou, Siqing Huang, M D Haifeng Chen, Jiagang Liu
[Background and objective] Primary spinal cord (PSC) glioblastoma multiforme GBM is extremely rare, which accounts for only 1.5% of all SC tumors. Therefore, its treatment is still ill defined. To elucidate prognostic factors, we performed a single-institutional retrospective review on the largest series to date of the patients with PSCGBM who underwent surgical resection in West China Hospital during the period between 2008 and 2014. A total of 14 PSCGBM patients were collected. [Method] Demographic, operative, and post-operative factors were recorded...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28343918/primary-lung-metastasis-of-glioblastoma-multiforme-with-epidural-spinal-metastasis-case-report
#5
Haydn A Hoffman, Charles H Li, Richard G Everson, Jennifer L Strunck, William H Yong, Daniel C Lu
Extracranial metastasis of glioblastoma multiforme (GBM) is rare, but has recently been reported with increasing frequency. GBM metastases typically present after a biopsy or resection of the primary tumor. An otherwise healthy 54year-old woman presented with recurring pleural effusions originally believed to be from a primary lung malignancy. The patient subsequently experienced a generalized tonic clonic seizure and a right temporal brain mass was discovered. The patient later developed weakness and radiculopathy, and an extramedullary extradural mass spreading from C7 to T6 was discovered...
July 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27846400/spinal-cordectomy-a-new-hope-for-morbid-spinal-conditions
#6
REVIEW
Subhas K Konar, Tanmoy K Maiti, Shyamal C Bir, Anil Nanda
A spinal cordectomy is a treatment option for several disorders of the spinal cord like post-traumatic syringomyelia, spinal cord tumor and myelomeningocele. We have done a systematic analysis of all reported cases of spinal cordectomy to investigate the possible outcomes and complications. A PubMed search was performed for literature published from 1949 to 2015 with search words "spinal cordectomy", "spinal cord transection" and "cordectomy for malignant spinal cord tumors" to select articles containing information about the indication, outcome and complication of spinal cordectomy performed for diverse etiologies...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27813458/a-systematic-review-of-overall-survival-in-pediatric-primary-glioblastoma-multiforme-of-the-spinal-cord
#7
REVIEW
Subhas K Konar, Shyamal C Bir, Tanmoy K Maiti, Anil Nanda
OBJECTIVE The incidence of primary spinal cord glioblastoma multiforme (GBM) in the pediatric age group is very rare. Only a few case series and case reports have been published in the literature; therefore, overall survival (OS) outcome and the as-yet poorly defined management options are not discussed in detail. The authors performed a cumulative survival analysis of all reported cases of pediatric spinal cord GBM to identify the predictive factors related to final survival outcome. METHODS A comprehensive search for relevant articles was performed on PubMed's electronic database MEDLINE for the period from 1950 to 2015 using the search words "malignant spinal cord tumor" and "spinal glioblastoma multiforme...
February 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27806338/mir-143-suppresses-the-epithelial-mesenchymal-transition-of-spinal-glioblastoma-through-down-regulation-of-erk5
#8
Yi Yan, Jing Wu, Mingjun Wu, Yongzhi Xia, Wenyuan Tang, Zhengbu Liao
The spinal glioblastoma (GBM) represents the one of most common tumors in humans. However, the biological processes and molecular mechanisms of spinal GBM are still unclear. It is known that miR-143 participates in the development of various tumor progressions. The present study was to evaluate the level of miR-143 in spinal GBM tissues and cells. We further investigated that the molecular mechanisms of miR-143 in U87 and U251 cell lines. Here, our data showed that the expression levels of miR-143 were significantly reduced in spinal GBM tissues and cell lines...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27695566/a-case-of-symptomatic-synchronous-cervical-and-cerebellar-metastasis-after-resection-of-thoracal-metastasis-from-temporal-glioblastoma-multiforme-without-any-local-recurrence
#9
Yasar Karatas, Sahika Liva Cengiz, Mehmet Erkan Ustun
Glioblastoma multiforme (GBM) is the most common and the most malignant primary intracranial tumor in adults and it is usually occurs between the age of 40 and 60 years. It is local invasive and recurrent tumor and hence that has a poor prognosis. However, recent advances in tumor surgery, irradiation and chemotherapeutic agent permit long survival and metastasis which is symptomatic. Previously studies reported spinal metastasis, but we report a first case of synchronous symptomatic cerebellar and cervical spinal metastasis after resection of symptomatic thoracic spinal metastasis from temporal GBM without any recurrence of excision areas...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27512613/multicentric-spinal-cord-and-brain-glioblastoma-without-previous-craniotomy
#10
Sayoa A de Eulate-Beramendi, Kelvin M Piña-Batista, Victor Rodrigo, Hector E Torres-Rivas, Juan C Rial-Basalo
BACKGROUND: Glioblastoma multiforme (GBS) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric gliomas lesions are widely separated in site and/or time and its incidence has been reported between 0.15 and 10%. Multicentric gliomas involving supratentorial and infratentorial region are even more rare. In most cases, infratentorial disease is seen after surgical manipulation or radiation therapy and is usually located in the cerebellum or cervical region...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27247548/imaging-of-human-glioblastoma-cells-and-their-interactions-with-mesenchymal-stem-cells-in-the-zebrafish-danio-rerio-embryonic-brain
#11
Milos Vittori, Barbara Breznik, Tajda Gredar, Katja Hrovat, Lilijana Bizjak Mali, Tamara T Lah
BACKGROUND: An attractive approach in the study of human cancers is the use of transparent zebrafish (Danio rerio) embryos, which enable the visualization of cancer progression in a living animal. MATERIALS AND METHODS: We implanted mixtures of fluorescently labeled glioblastoma (GBM) cells and bonemarrow-derived mesenchymal stem cells (MSCs) into zebrafish embryos to study the cellular pathways of their invasion and the interactions between these cells in vivo...
June 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27217661/late-onset-leptomeningeal-and-whole-spine-metastasis-from-supratentorial-glioblastoma-multiforme-an-uncommon-manifestation-of-a-common-tumor
#12
Divyam Sharma, Anshul Gupta, Gurupal S Dhillon, Satnam Singh Chhabra
Glioblastoma multiforme (GBM) is one of the most common and aggressive primary brain tumors, composing 12-20% of all the intracranial tumors in adults with a highly malignant course and average life expectancy of approximately 12-14 months following initial diagnosis. Leptomeningeal or intramedullary metastasis from primary GBM is a rare phenomenon with a poor prognosis. We present a rare case of GBM with late onset intramedullary, extramedullary, as well as leptomeningeal spinal metastasis.
April 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/26887384/the-critical-role-of-srpk1-in-emt-of-human-glioblastoma-in-the-spinal-cord
#13
Zhengbu Liao, Jing Wu, Mingjun Wu, Yi Yan, Haiquan Wang, Chongjie Cheng, Wenyuan Tang
Up to now, the serine-arginine protein kinase 1 (SRPK1) has been suggested as an important signal mediator, which is implicated in the development of cancers. Unfortunately, some molecular pathways in SRPK1-mediated epithelial-mesenchymal transition (EMT) in human spinal glioblastoma have been not elucidated. In this work, we detected the expression of SRPK1 in human spinal glioblastoma tissues and GBM cell lines and analyzed the relevant molecular proteins using in vitro experiments, including RT-PCR, gene silencing, and Western blot...
April 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/26713151/glioblastoma-multiforme-in-the-pineal-region-with-leptomeningeal-dissemination-and-lumbar-metastasis
#14
Ryosuke Matsuda, Yasuo Hironaka, Tadashi Suigimoto, Hiroyuki Nakase
We report a case of a 31-year-old woman with glioblastoma multiforme (GBM) in the pineal region with associated leptomeningeal dissemination and lumbar metastasis. The patient presented with severe headache and vomiting. Magnetic resonance imaging (MRI) of the brain showed a heterogeneously enhanced tumor in the pineal region with obstructive hydrocephalus. After an urgent ventricular-peritoneal shunt, she was treated by subtotal resection and chemotherapy concomitant with radiotherapy. Two months after surgery, MRI showed no changes in the residual tumor but leptomeningeal dissemination surrounding the brainstem...
November 2015: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/26601809/primary-spinal-cord-glioblastoma-multiforme-treated-with-temozolomide
#15
REVIEW
Silvia Hernández-Durán, Amade Bregy, Ashish H Shah, Simon Hanft, Ricardo J Komotar, Glen R Manzano
Since virtually no trials have evaluated the effectiveness of temozolomide (TMZ) in the treatment of spinal cord (SC) glioblastoma multiforme (GBM), we conducted a systematic review to evaluate its efficacy. Primary SC GBM is rare. Its management remains unclear, even though treatment guidelines have been established since 2005 for its cranial counterpart. We performed a medical subject heading search with the terms “glioblastoma” and “primary spinal cord neoplasms, intramedullary”. We stratified the papers into two groups according to the use of TMZ, and analyzed survival rates using the Kaplan–Meier method with a two-sided log-rank scale...
December 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26458640/primary-spinal-glioblastoma-treated-with-adjuvant-radiation-and-temozolomide-report-of-two-cases
#16
LETTER
Supriya Mallick, Renu Madan, P K Julka
Primary spinal glioblastoma multiforme (GBM) is a rare entity, which is invariably associated with poor outcome. Standard treatment is surgery followed by post-operative radiotherapy. Due to paucity of cases role of chemotherapy is investigational. We intend to report two cases of primary spinal GBM treated with radiation and adjuvant temozolomide.
July 2015: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/26376654/location-of-brain-tumor-intersecting-white-matter-tracts-predicts-patient-prognosis
#17
Nikolai J Mickevicius, Alexander B Carle, Trevor Bluemel, Stephanie Santarriaga, Fallon Schloemer, Derrick Shumate, Jennifer Connelly, Kathleen M Schmainda, Peter S LaViolette
Brain tumor cells invade adjacent normal brain along white matter (WM) bundles of axons. We therefore hypothesized that the location of tumor intersecting WM tracts would be associated with differing survival. This study introduces a method, voxel-wise survival analysis (VSA), to determine the relationship between the location of brain tumor intersecting WM tracts and patient prognosis. 113 primary glioblastoma (GBM) patients were retrospectively analyzed for this study. Patient specific tumor location, defined by contrast-enhancement, was combined with diffusion tensor imaging derived tractography to determine the location of axons intersecting tumor enhancement (AXITEs)...
November 2015: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26348566/predictive-factors-determining-the-overall-outcome-of-primary-spinal-glioblastoma-multiforme-an-integrative-survival-analysis
#18
REVIEW
Subhas K Konar, Tanmoy K Maiti, Shyamal C Bir, Piyush Kalakoti, Papireddy Bollam, Anil Nanda
OBJECTIVE: Primary glioblastoma multiforme of the spinal cord is a rare entity. The aim of this study was to perform an integrative analysis of patients whose cases were selected from the published studies, and to examine the influence of various factors on overall outcomes. METHODS: A PubMed search was performed for literature published from 1938 to 2015 to select the articles containing information about the demographics, tumor location, critical event (death), time to events, and treatment characteristics...
February 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26251789/primary-spinal-glioblastoma-multiforme-with-secondary-manifestation-as-a-cerebral-angioglioma-literature-review-and-case-report
#19
Thomas Linsenmann, Thomas Westermaier, Giles Hamilton Vince, Camelia Maria Monoranu, Mario Löhr, Ralf-Ingo Ernestus, Christian Stetter
Primary intramedullary spinal glioblastoma multiforme (sGBM) with a secondary cerebral manifestation is a very rare entity with a poor outcome. Case studies show a mean average of survival of 10 months after diagnosis. These tumors tend to develop at a young age. A combination with an arteriovenous malformation in the same location has never been published before. Vascular malformations in association with cerebral glioblastomas have only been reported in five cases so far. Proangiogenic factors are assumed to be involved in the appearance of both entities...
July 2015: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/26230418/qualitative-analysis-of-spinal-intramedullary-lesions-using-pet-ct
#20
Kentaro Naito, Toru Yamagata, Hironori Arima, Junya Abe, Naohiro Tsuyuguchi, Kenji Ohata, Toshihiro Takami
OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-(11)C]-methionine (MET)- or [(18)F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight...
July 31, 2015: Journal of Neurosurgery. Spine
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