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Diabetic management

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https://www.readbyqxmd.com/read/29677678/%C3%AE-glucosidase-enzyme-inhibitory-effects-and-ursolic-and-oleanolic-acid-contents-of-fourteen-anatolian-salvia-species
#1
Zeynep Kalaycıoğlu, Sesil Uzaşçı, Tuncay Dirmenci, F Bedia Erim
During the last decade, ursolic and oleanolic acids have been of considerable interest because of their α-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes. A simple and sensitive reversed-phase HPLC method was developed for the simultaneous determination of ursolic acid and oleanolic acid. The optimal mobile phase was selected as 85% acetonitrile solution. The limit of detection of the method for ursolic acid and oleanolic acid were 14 ng mL-1 and 13 ng mL-1 , respectively...
April 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#2
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677458/intake-of-diacylglycerols-and-the-fasting-insulin-and-glucose-concentrations-a-meta-analysis-of-5-randomized-controlled-studies
#3
Xu Tongcheng, Jia Min, Li Xia, Qiu Bin, Zhang Yuan, Liu Wei, Zong Aizhen, Liu Lina, Du Fangling
Diacylglycerol (DAG) supplementation has been shown to be associated with the health improvement of patients with diabetes mellitus, although this efficacy is uncertain. We quantitatively examined the effect of dietary DAG on fasting serum glucose and insulin concentrations by conducting a meta-analysis of randomized controlled trials. Potential papers were initially searched from electronic databases of Medline, Embase, and Cochrane Library. Inclusion criteria required the trial to be randomized, with triacylglycerol (TAG) controlled with fasting serum glucose or insulin concentration as one of the end points...
April 20, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29676550/corrigendum-table-and-text-correction-recent-updates-on-type-1-diabetes-mellitus-management-for-clinicians
#4
Ahmed Iqbal, Peter Novodvorsky, Simon R Heller
This corrects the article on p. 3 in vol. 42, PMID: 29504302.
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676545/hemorheologic-alterations-in-patients-with-type-2-diabetes-mellitus-presented-with-an-acute-myocardial-infarction
#5
Kyu Hwan Park, Ung Kim, Kang Un Choi, Jong Ho Nam, Jung Hee Lee, Chan Hee Lee, Jang Won Son, Jong Seon Park, Dong Gu Shin, Kyu Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang Soo Suh
BACKGROUND: Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676539/past-and-current-status-of-adult-type-2-diabetes-mellitus-management-in-korea-a-national-health-insurance-service-database-analysis
#6
REVIEW
Seung Hyun Ko, Kyungdo Han, Yong Ho Lee, Junghyun Noh, Cheol Young Park, Dae Jung Kim, Chang Hee Jung, Ki Up Lee, Kyung Soo Ko
Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675797/treatment-intensification-in-type-2-diabetes-a-real-world-study-of-2-oad-regimens-glp-1-ras-or-basal-insulin
#7
Lawrence Blonde, Denis Raccah, Elisheva Lew, Juliana Meyers, Elena Nikonova, Mayank Ajmera, Keith L Davis, Monica Bertolini, Bruno Guerci
INTRODUCTION: Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result in uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among patients with uncontrolled T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin in a real-world setting. METHODS: Adults with T2D on OAD monotherapy were identified in the MarketScan claims database (2007-2014)...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675479/associations-of-diabetic-retinopathy-with-retinal-neurodegeneration-on-the-background-of-diabetes-mellitus-overview-of-recent-medical-studies-with-an-assessment-of-the-impact-on-healthcare-systems
#8
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29674706/discordance-in-glycemic-categories-and-regression-to-normality-at-baseline-in-10-000-people-in-a-type-2-diabetes-prevention-trial
#9
Mike Sampson, Tim Elwell-Sutton, Max O Bachmann, Allan Clark, Ketan K Dhatariya, Clare Ferns, Amanda Howe, W Garry John, Gerry Rayman, Leyla Swafe, Jeremy Turner, Melanie Pascale
The world diabetes population quadrupled between 1980 and 2014 to 422 million and the enormous impact of Type 2 diabetes is recognised by the recent creation of national Type 2 diabetes prevention programmes. There is uncertainty about how to correctly risk stratify people for entry into prevention programmes, how combinations of multiple 'at high risk' glycemic categories predict outcome, and how the large recently defined 'at risk' population based on an elevated glycosylated haemoglobin (HbA1c) should be managed...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674306/diabeo-app-software-and-telemedicine-versus-usual-follow-up-in-the-treatment-of-diabetic-patients-protocol-for-the-telesage-randomized-controlled-trial
#10
Nathalie Jeandidier, Lucy Chaillous, Sylvia Franc, Pierre-Yves Benhamou, Pauline Schaepelynck, Hélène Hanaire, Bogdan Catargi, Anne Farret, Pierre Fontaine, Bruno Guerci, Yves Reznik, Alfred Penfornis, Sophie Borot, Pierre Serusclat, Yacine Kherbachi, Geneviève D'Orsay, Bruno Detournay, Pierre Simon, Guillaume Charpentier
BACKGROUND: Self-management of diabetes minimizes the risk of macrovascular and microvascular complications, but understanding and/or adherence to self-management recommendations is often suboptimal. DIABEO is a smartphone app (downloaded via the internet) used to calculate bolus insulin doses. A previous study (TELEDIAB 1) showed that the use of DIABEO was associated with a significant improvement in glycemic control in patients with poorly controlled type 1 diabetes mellitus, particularly when combined with teleconsultations with physicians...
April 19, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29673848/overcoming-missed-opportunities-in-diabetes-management-to-improve-outcomes-for-hospitalized-patients-with-diabetes
#11
Michael Oravec, James Salem, Jason Kunz, Michelle Cudnik, Lynn Clough, Robert Woods, Megan Elavsky
AIMS: The purpose of this study is to assess the impact of hospitalization on 6-12 month medication adjustment and glycemic control. METHODS: We conducted a retrospective cohort study of hospitalized and non-hospitalized patients with diabetes of an internal medicine residency continuity clinic. Patients had baseline and outcome HbA1c taken 6-12 months apart. Multivariate linear regression was used to model predictors of HbA1c change from baseline to outcome. Multivariate logistic regression was used to model predictors of medication adjustment between baseline and outcome clinic visits...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673847/challenges-in-the-management-of-type-2-diabetes-among-native-women-in-the-united-arab-emirates
#12
Walaa Abuelmagd, Bachar Afandi, Helle Håkonsen, Seham Khmidi, Else-Lydia Toverud
AIM: To investigate type 2 diabetes mellitus (T2DM) management in native female patients in the United Arab Emirates (UAE). METHODS: Ninety women from the outpatient diabetes clinic at Tawam Hospital, UAE, were interviewed face-to-face using a structured questionnaire. Glycated hemoglobin (HbA1c), blood pressure, lipid panel, weight and body mass index (BMI) were extracted from medical records. RESULTS: Mean age was 57.5 (SD:12.7) years. Forty-five participants (50...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673309/sodium-glucose-co-transporter-2-inhibitors-beyond-glucose-lowering
#13
Asli F Ceylan, Sidney Y Ren
Diabetes is an important cause of morbidity and mortality in worldwide. Management of blood glucose is critical for diabetic patients since diabetes carries risk for many diseases and disorders. Although there are several antidiabetic agents in the markets for a long time, some of the agents have dose-limiting side effects, such as hypoglycemia and weight gain which limits their ability to reduce cardiovascular complications. Sodium glucose co-transporter 2 (SGLT2) inhibitors are new class of antidiabetic agents which exerts their effects insulin-independent mechanism therefore they do not cause hypoglycemia in the diabetic patients...
April 19, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29673244/changes-in-body-composition-blood-lipid-profile-and-growth-factor-hormone-in-a-patient-with-prader-willi-syndrome-during-24-weeks-of-complex-exercise-a-single-case-study
#14
Hee Joung Joung, In Soo Lim
PURPOSE: Prader-Willi syndrome (PWS) is a genetic disorder characterized by excessive appetite with progressive obesity and growth hormone (GH) deficiency. Excessive eating causes progressive obesity with increased risk of morbidities and mortality. Although GH treatment has beneficial effects on patients with PWS, adverse events have occurred during GH treatment. Exercise potentially has a positive effect on obesity management. The purpose of this research was to examine the effects of 24-week complex exercise program on changes in body composition, blood lipid profiles, and growth factor hormone levels in a patient with PWS...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29672991/glycaemic-optimization-for-patients-with-cardiac-disease-a-before-and-after-study
#15
Tripti Joshi, Sarah-Jane Pullen, Alison Gebuehr, Christopher Oldmeadow, John Richard Attia, Shamasunder Halady Acharya
AIM: To investigate if glycaemic profiles and outcomes of patients with diabetes admitted for cardiothoracic surgery or acute coronary syndrome improved after implementation of a structured glycaemia management guideline. METHODS: This is a retrospective before-and-after comparative analysis of outcomes for all consecutive cardiothoracic and acute coronary syndrome patients with diabetes (N = 375), who were admitted at our tertiary-care university-affiliated hospital during the preguideline period (July-December, 2013) and the postguideline period (July-December, 2014)...
April 19, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29672871/sex-differences-in-the-contemporary-management-of-hiv-patients-admitted-for-acute-myocardial-infarction
#16
Gbolahan O Ogunbayo, Katrina Bidwell, Naoki Misumida, Le Dung Ha, Ahmed Abdel-Latif, Claude S Elayi, Susan Smyth, Adrian W Messerli
BACKGROUND: Studies have reported sex differences in the management of patients with acute myocardial infarction (AMI) in the general population. This observational study is designed to evaluate whether sex differences exist in the contemporary management of human immunodeficiency virus (HIV) patients admitted for diagnosis of AMI. HYPOTHESIS: There is no difference in management of HIV patients with AMI. METHODS: Using the National Inpatient Sample database, we identified patients with a primary diagnosis of AMI and a secondary diagnosis of HIV...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29672829/timing-of-diagnosis-of-gestational-diabetes-and-pregnancy-outcomes-a-retrospective-cohort
#17
Alexis Shub, Tess Chee, Alexandra Templeton, Deborah Boyce, Catharine McNamara, Christine Houlihan, Leonid Churilov, Elizabeth A McCarthy
BACKGROUND: Recent guidelines suggest screening high-risk women in early pregnancy for gestational diabetes (GDM); however, there is little evidence to support this. AIMS: To compare pregnancy outcomes associated with diabetes for women with risk factors for GDM according to gestation of diagnosis. Early GDM was defined as a positive test before 20 weeks gestation, late GDM as a positive test at 20 or more weeks and no GDM when both tests were negative. MATERIALS AND METHODS: Retrospective analysis in an Australian tertiary hospital of women who underwent a glucose tolerance test in pregnancy prior to 20 weeks gestation, and a repeat test after 20 weeks gestation if the initial test was negative...
April 19, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29672567/costs-and-effectiveness-of-pharmacist-led-group-medical-visits-for-type-2-diabetes-a-multi-center-randomized-controlled-trial
#18
Wen-Chih Wu, Tracey H Taveira, Sean Jeffery, Lan Jiang, Lisa Tokuda, Joanna Musial, Lisa B Cohen, Fred Uhrle
OBJECTIVES: The effectiveness and costs associated with addition of pharmacist-led group medical visits to standard care for patients with Type-2 Diabetes Mellitus (T2DM) is unknown. METHODS: Randomized-controlled-trial in three US Veteran Health Administration (VHA) Hospitals, where 250 patients with T2DM, HbA1c >7% and either hypertension, active smoking or hyperlipidemia were randomized to either (1) addition of pharmacist-led group-medical-visits or (2) standard care alone for 13 months...
2018: PloS One
https://www.readbyqxmd.com/read/29672293/microarray-analysis-of-long-noncoding-rnas-in-female-diabetic-peripheral-neuropathy-patients
#19
Lin Luo, Lin-Dan Ji, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Wen-Hua Zhou
BACKGROUND/AIMS: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Because of its controversial pathogenesis, DPN is still not diagnosed or managed properly in most patients. METHODS: In this study, human lncRNA microarrays were used to identify the differentially expressed lncRNAs in DM and DPN patients, and some of the discovered lncRNAs were further validated in additional 78 samples by quantitative realtime PCR (qRT-PCR)...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29671627/the-impact-of-non-medical-switch-on-type-2-diabetes-patients-treated-with-canagliflozin-in-the-commercially-insured-us-population
#20
Lawrence Blonde, Chakkarin Burudpakdee, Victoria Divino, Brahim Bookhart, Jennifer Cai, Michael Pfeifer, Craig I Coleman
OBJECTIVE: To assess the impact of non-medical switch (NMS) from canagliflozin on antihyperglycemic agent (AHA) medication taking behavior. METHODS: This retrospective real-world database analysis included patients with type 2 diabetes with a prescription claim for canagliflozin between 8/2015 and 1/2016 using administrative claims and longitudinal prescription data. Patients with NMS from canagliflozin were identified as those with discontinuation or switch of canagliflozin and enrolled in a pharmacy benefit manager that removed CANA from formulary in 2016...
April 19, 2018: Current Medical Research and Opinion
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