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Diabetic neuropathy

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https://www.readbyqxmd.com/read/29149211/occupational-exposure-to-unburnt-tobacco-and-potential-risk-of-toxic-optic-neuropathy-a-cross-sectional-study-among-beedi-rollers-in-selected-rural-areas-of-coastal-karnataka-india
#1
Soujanya Kaup, Ansaba Naseer, Siddharudha Shivalli, Cynthia Arunachalam
BACKGROUND: Beedi also known as poor man's cigarette is manufactured in almost all major states of India. Beedi workers are exposed to various health risks. There is an increased risk of systemic absorption of tobacco through skin and mucous membrane. The optic nerve is susceptible to damage from several toxic substances including tobacco. This group of disorders is known as toxic optic neuropathy (TON). The association of TON with occupational exposure to unburnt tobacco in beedi rollers has not been explored...
2017: PloS One
https://www.readbyqxmd.com/read/29147011/lower-serum-extracellular-superoxide-dismutase-levels-are-associated-with-polyneuropathy-in-recent-onset-diabetes
#2
Alexander Strom, Kirti Kaul, Jutta Brüggemann, Iris Ziegler, Ilka Rokitta, Sonja Püttgen, Julia Szendroedi, Karsten Müssig, Michael Roden, Dan Ziegler
Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations of extracellular superoxide dismutase (SOD3), thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) in 107 type 1 and 215 type 2 diabetes patients from the German Diabetes Study baseline cohort and 37 glucose-tolerant individuals (controls)...
November 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29145322/ptosis-as-the-only-manifestation-of-diabetic-superior-division-oculomotor-nerve-palsy-a-case-report
#3
Ping-Yin Chou, Kun-Han Wu, Poyin Huang
RATIONALE: Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating the superior rectus and levator palpebrae superioris. The diabetic oculomotor nerve palsy may affect isolated superior or inferior division of the oculomotor nerve, but diplopia usually exists...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143802/the-inhibitory-effects-of-cobalt-protoporphyrin-ix-and-cannabinoid-2-receptor-agonists-in-type-2-diabetic-mice
#4
Christina McDonnell, Sergi Leánez, Olga Pol
The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 receptors (CB2R) has not been assessed. Using male mice BKS.Cg-m+/+Leprdb/J (db/db) we investigated if treatment with cobalt protoporphyrin IX (CoPP), an HO-1 inductor, inhibited mechanical allodynia, hyperglycemia and obesity associated to type 2 diabetes. The antinociceptive effects of JWH-015 and JWH-133 (CB2R agonists) administered with and without CoPP or sulforaphane (SFN), a Nrf2 transcription factor activator, have been also evaluated...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29142986/cardiac-autonomic-neuropathy-predicts-all-cause-and-cardiovascular-mortality-in-patients-with-end-stage-renal-failure-a%C3%A2-5-year-prospective-study
#5
Dimitrios Doulgerakis, Ioannis Moyssakis, Chris J Kapelios, Ioanna Eleftheriadou, Stamatia Chorepsima, Spyridon Michail, Nikolaos Tentolouris
Introduction: Chronic renal disease is associated with increased cardiovascular (CV) mortality. Cardiac autonomic neuropathy (CAN) is predictive of mortality for diseases that affect the autonomic nervous system. We prospectively evaluated the prognostic value of indexes of left ventricular (LV) function and CAN in all-cause and CV mortality of patients with end-stage renal failure (ESRF). Methods: A total of 133 patients with ESRF were recruited. LV function was evaluated by echocardiography, whereas cardiac autonomic function was assessed using the battery of the 4 standardized tests proposed by Ewing...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29141105/the-feasibility-of-intraperitoneal-placenta-derived-mesenchymal-stem-cell-injection-in-stomachs-of-diabetic-mice
#6
Jong Min Park, Sang Hwan Lee, Kwang Il Kim, Won Hee Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong
BACKGROUND/AIMS: Diabetic gastropathy is associated with loss of Interstitial cells of Cajal (ICCs) and autonomic neuropathy. Effective management for diabetic gastropathy is still unavailable. This study was aimed to confirm the pathogenetic changes in diabetic gastropathy and to examine the effect of treatment with placental derived mesenchymal stem cells (PDMSCs) in stomachs of animal models. METHODS: Fourteen NOD/ShiLtJ mice of 8 weeks were bled until week 30...
November 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29139278/improving-pain-control-in-diabetic-neuropathy
#7
Peter Paisley, Mick Serpell
Diabetic neuropathy is thought to affect 1.9% of the world’s population and 50% of patients with a diagnosis of diabetes mellitus which would equate to 2.25 million people in the UK. The term diabetic neuropathy includes multiple distinct clinical entities that have been classified under the broad headings of focal and multifocal neuropathies and symmetrical neuropathies. Peripheral diabetic neuropathy, a chronic distal symmetrical predominantly sensory neuropathy, is the most common form of diabetic neuropathy...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29137090/diabetic-and-sympathetic-influences-on-the-water-permeability-barrier-function-of-human-skin-as-measured-using-transepidermal-water-loss-a-case-control-study
#8
Seung Hoon Han, Ji Woong Park
The presence of long-standing hyperglycemic conditions has been suggested to lead to many skin problems associated with an impaired skin barrier function. However, the relationship between impaired skin barrier status and altered peripheral nervous system function has not yet been determined. The purpose of this study was to investigate the water evaporation rate as a measure of the permeability barrier function of diabetic skin and its relationship to diabetic sensorimotor polyneuropathy (DSPN) and peripheral autonomic neuropathy (PAN) using well-controlled confounding variables...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137013/combination-of-ewing-test-heart-rate-variability-and-heart-rate-turbulence-analysis-for-early-diagnosis-of-diabetic-cardiac-autonomic-neuropathy
#9
Kun Lin, Liling Wei, Zhihua Huang, Qiong Zeng
The aim of this study was to compare and analyze Ewing test, heart rate variability (HRV), and heart rate turbulence (HRT) in the diagnosis of cardiac autonomic neuropathy (CAN) in diabetic patients.Ninety diabetic patients (age 18-78) and 20 nondiabetic control subjects were studied. Standard Ewing test and 24-hour Holter was performed in all participants to evaluate CAN. Patients with Ewing score ≥2 were classified as CAN+.The rate of CAN+ in diabetic patients [44.4% (40/90)] was higher than that in the controls [5% (1/20)] (P < ...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137012/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-mellitus
#10
Tingting Xu, Zihua Weng, Chu Pei, Siyuan Yu, Yating Chen, Wenjie Guo, Xingzuo Wang, Peng Luo, Jia Sun
To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125834/analysis-of-a-screening-system-for-diabetic-cardiovascular-autonomic-neuropathy-in-china
#11
Ying Xue, Yubao Lv, Zihui Tang, Jingcheng Dong
BACKGROUND The aim of this study was to create a screening system for diabetic cardiovascular autonomic neuropathy (DCAN) in diabetic patients. MATERIAL AND METHODS A Chinese cohort of 455 diabetic participants was recruited between 2011 and 2013. Short-term heart rate variability testing was used to evaluate cardiovascular autonomic function. A simple model was developed using multiple variable regression to include only significant risk factors that were simple and easily assessed. A DCAN score was determined based on the coefficients of the multiple variable model...
November 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29125108/lipoic-acid-combined-with-epalrestat-versus-lipoic-acid-in-treating-diabetic-peripheral-neuropathy-a-meta-analysis
#12
Xiao-Tong Wang, Hai-Xiong Lin, Shu-Ai Xu, Ying-Kun Lu
Objective To compare the clinical effectiveness of lipoic acid combined with epalrestat versus lipoic acid in treating diabetic peripheral neuropathy(DPN). Methods Randomized controlled trials(RCTs) and clinical controlled trials on lipoic acid versus epalrestat for DPN before February 2016 were searched through five databases:CNKI,CBM,VIP,Wanfang,and PubMed. The quality of the included trials were assessed using Cochrane software and Jadad scores. Data were analyzed with Review Manager 5.3 software. Results Nine studies were included in the analysis...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29122782/study-protocol-for-the-cities-changing-diabetes-programme-a-global-mixed-methods-approach
#13
A David Napier, John J Nolan, Malene Bagger, Louise Hesseldal, Anna-Maria Volkmann
INTRODUCTION: Urban living has been shown to affect health in various ways. As the world is becoming more urbanised and almost two-thirds of people with diabetes now live in cities, research into the relationship between urban living, health and diabetes is key to improving the lives of many. The majority of people with diabetes have type 2 diabetes, a subset linked to overweight and obesity, decreased physical activity and unhealthy diets. Diabetes has significant consequences for those living with the condition as well as their families, relationships and wider society...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29122628/a-novel-curcumin-derivative-for-the-treatment-of-diabetic-neuropathy
#14
Daniel J Daugherty, Alexandra Marquez, Nigel A Calcutt, David Schubert
Neuropathy is a common complication of long-term diabetes. Proposed mechanisms of neuronal damage caused by diabetes that are downstream of hyperglycemia and/or loss of insulin signaling include ischemic hypoxia, inflammation and loss of neurotrophic support. The curcumin derivative J147 is a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy...
November 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29121964/muscle-force-distribution-of-the-lower-limbs-during-walking-in-diabetic-individuals-with-and-without-polyneuropathy
#15
Aline A Gomes, Marko Ackermann, Jean P Ferreira, Maria Isabel V Orselli, Isabel C N Sacco
BACKGROUND: Muscle force estimation could advance the comprehension of the neuromuscular strategies that diabetic patients adopt to preserve walking ability, which guarantees their independence as they deal with their neural and muscular impairments due to diabetes and neuropathy. In this study, the lower limb's muscle force distribution during gait was estimated and compared in diabetic patients with and without polyneuropathy. METHODS: Thirty individuals were evaluated in a cross-sectional study, equally divided among controls (CG) and diabetic patients with (DNG) and without (DG) polyneuropathy...
November 9, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29121795/berberine-ameliorates-diabetic-neuropathy-trpv1-modulation-by-pkc-pathway
#16
Yan Zan, Cui-Xing Kuai, Zhi-Xia Qiu, Fang Huang
In recent years, berberine has increasingly become a topic of research as a treatment for diabetes due to its repair function, which recovers damaged pancreatic β cells. However, it is the complications of diabetes that seriously affect patients' life quality and longevity, among which diabetic neuropathy and the consequent acute pain are the most common. In this study, we established STZ-induced diabetic models to observe whether berberine, a main constitute of Coptis chinensis Franch which has shown good hypoglycemic effects, could relieve diabetes-induced pain and explored its possible mechanism in rats and mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121540/computer-aided-diagnosis-of-diabetic-foot-using-infrared-thermography-a-review
#17
Muhammad Adam, Eddie Y K Ng, Jen Hong Tan, Marabelle L Heng, Jasper W K Tong, U Rajendra Acharya
Diabetes mellitus (DM) is a chronic metabolic disorder that requires regular medical care to prevent severe complications. The elevated blood glucose level affects the eyes, blood vessels, nerves, heart, and kidneys after the onset. The affected blood vessels (usually due to atherosclerosis) may lead to insufficient blood circulation particularly in the lower extremities and nerve damage (neuropathy), which can result in serious foot complications. Hence, an early detection and treatment can prevent foot complications such as ulcerations and amputations...
October 26, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29119607/impaired-peripheral-nerve-regeneration-in-type-2-diabetic-mouse-model
#18
Pham Minh Vuong, H Tu Nguyen, Tayo Katano, Shinji Matsumura, Akira Saito, Akihiro Yamada, Hidemasa Furue, Seiji Ito
Peripheral neuropathy is one of the most common and serious complications of type-2 diabetes. Diabetic neuropathy is characterized by a distal symmetrical sensorimotor polyneuropathy, and its incidence increases in patients 40 years of age or older. In spite of extensive research over decades, there are few effective treatments for diabetic neuropathy besides glucose control and improved lifestyle. The earliest changes in diabetic neuropathy occur in sensory nerve fibers, with initial degeneration and regeneration resulting in pain...
November 9, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29119118/diagnostic-accuracy-of-monofilament-tests-for-detecting-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#19
REVIEW
Fengyi Wang, Jiaqi Zhang, Jiadan Yu, Shaxin Liu, Rengang Zhang, Xichao Ma, Yonghong Yang, Pu Wang
Objective: To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods: We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29118059/diabetes-care-disparities-in-long-standing-type-1-diabetes-in-canada-and-the-united-states-a-cross-sectional-comparison
#20
Alanna Weisman, Leif E Lovblom, Hillary A Keenan, Liane J Tinsley, Stephanie D'Eon, Genevieve Boulet, Mohammed A Farooqi, Julie A Lovshin, Andrej Orszag, Yuliya Lytvyn, Michael H Brent, Narinder Paul, Vera Bril, David Z Cherney, Bruce A Perkins
OBJECTIVE: To assess national differences in diabetes care and quality of life (QOL) between individuals with long-standing type 1 diabetes (≥50 years) in Canada and the U.S. RESEARCH DESIGN AND METHODS: Cross-sectional data from identical surveys administered in the Canadian Study of Longevity in Diabetes and the Joslin Medalist Study, collected in 2013-2016 and 2005-2011, respectively, were compared. Laboratory values and ophthalmic examination were completed by clinical care physicians for Canadians and the Joslin Clinic for Americans...
November 8, 2017: Diabetes Care
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