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Diabetic neuropathy

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https://www.readbyqxmd.com/read/28634852/incidence-of-prolonged-qtc-and-severe-hypoglycemia-in-type-1-diabetes-the-eurodiab-prospective-complications-study
#1
Cristina Amione, Sara Giunti, Paolo Fornengo, Sabita S Soedamah-Muthu, Nish Chaturvedi, J H Fuller, Federica Barutta, Gabriella Gruden, Graziella Bruno
AIMS: To assess the independent role of severe hypoglycemia on 7-year cumulative incidence of prolonged QTc in a large cohort of patients with type 1 diabetes. METHODS: People with type 1 diabetes recruited by the EURODIAB Prospective Complications Study who had normal QTc were examined at baseline and after 7 years with standardized methods (n = 1415; mean age ± SD 32.1 ± 9.6 years; diabetes duration 14.2 ± 8.8 years). Hypoglycemic episodes were assessed by a questionnaire...
June 20, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28633782/factors-predicting-length-of-hospital-stay-and-extended-care-facility-admission-after-hindfoot-arthrodesis-procedures
#2
Jacob Deister, Brian G Cothern, Chad Williams, Andrew W Froehle, Richard T Laughlin
Delayed identification of patients requiring admission to extended care facilities (ECFs) can lead to greater healthcare costs through an increased length of hospital stay (LOHS). Previous studies of hip and knee arthroplasty identified factors associated with a likely discharge to an ECF. These issues have not been extensively studied for major hindfoot procedures. We conducted a retrospective review of 198 cases treated during a 3-year period to identify the risk factors for an extended LOHS and ECF admission after ankle arthrodesis, triple arthrodesis, pantalar arthrodesis, and subtalar arthrodesis...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633615/experts-opinion-on-manual-wheelchair-adjustments-for-adults-with-diabetes
#3
Sophie-Anne Scherrer, Joelle Chu Yu Chee, Nhi Vu, Patrice Lu, Michelle Ishack, Philippe S Archambault
Diabetes is a global health concern that can lead to mobility limitations necessitating a wheelchair. However, there are currently no guidelines for wheelchair adjustments tailored to the diabetic population. PURPOSE: To describe relevant manual wheelchair adjustments for adults with diabetes, and to explore how these adjustments apply to populations living in less-resourced countries. METHODS: Semi-structured interviews were conducted with 13 wheelchair experts from five different countries working with adult with diabetes...
March 2, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28633005/autophagy-impairment-mediated-by-s-nitrosation-of-atg4b-leads-to-neurotoxicity-in-response-to-hyperglycemia
#4
Yazi Li, Yuying Zhang, Lei Wang, Ping Wang, Yanhong Xue, Xiaopeng Li, Xinhua Qiao, Xu Zhang, Tao Xu, Guanghui Liu, Peng Li, Chang Chen
The majority of diabetic patients develop neuropathy and there is an increasing prevalence of neurodegeneration in the central nervous system (CNS). However, the mechanism behind is poorly understood. Here we first observed that macroautophagy/autophagy was suppressed in the hippocampus of diabetic GK rats with hyperglycemia, whereas it was unchanged in ob/ob mice without hyperglycemia. Autophagy could be directly inhibited by high glucose in mouse primary hippocampal neurons. Moreover, autophagy was protective in high-glucose-induced neurotoxicity...
June 20, 2017: Autophagy
https://www.readbyqxmd.com/read/28627227/smarter-sole-survival
#5
Bijan Najafi, Eyal Ron, Ana Enriquez, Ivan Marin, Javad Razjouyan, David G Armstrong
OBJECTIVE: This study examined adherence to alert-based cues for plantar pressure offloading in patients with diabetic foot disease. METHOD AND DESIGN: Participants (n = 17) with in diabetic foot remission (history of neuropathic ulceration) were instructed to wear a smart insole system (the SurroSense Rx, Orpyx Medical Technologies Inc, Calgary, Canada) over a three-month period. This device is designed to cue offloading to manage unprotected sustained plantar pressures in an effort to prevent foot ulceration...
January 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28627217/using-plantar-electrical-stimulation-to-improve-postural-balance-and-plantar-sensation-among-patients-with-diabetic-peripheral-neuropathy
#6
Bijan Najafi, Talal K Talal, Gurtej Singh Grewal, Robert Menzies, David G Armstrong, Lawrence A Lavery
OBJECTIVE: People with diabetic peripheral neuropathy (DPN) often exhibit deteriorations in motor-performance mainly due to lack of plantar-sensation. The study explored effectiveness of plantar electrical-stimulation therapy to enhance motor-performance among people with DPN. DESIGN AND METHODS: Using a double-blinded model, 28 volunteers with DPN (age: 57.8 ± 10.2 years) were recruited and randomized to either intervention (IG: n = 17) or control (CG: n = 11) group...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28626198/the-therapeutic-effect-of-dexmedetomidine-on-rat-diabetic-neuropathy-pain-and-the-mechanism
#7
Yuecheng Lu, Baohua Lin, Junmin Zhong
Diabetic neuropathy pain (DNP) is a common chronic complication of diabetes characterized by spontaneous pain, hyperalgesia and allodynia. Dexmedetomidine is a selective α2 adrenergic agonist that relieves sympathetic nervous tension and reduces the release of glutamate. Thus, it is possible that dexmedetomidine may relieve DNP as well. In this study, we examined the effect of dexmedetomidine on DNP in the presence or absence of the α2 adrenergic antagonist yohimbine in rats utilizing a streptozotocin (STZ)-induced diabetes as a model of DNP...
June 14, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28625567/dose-postural-control-improve-following-application-of-transcutaneous-electrical-nerve-stimulation-in-diabetic-peripheral-neuropathic-patients-a-randomized-placebo-control-trial
#8
Z Saadat, Z Rojhani-Shirazi, L Abbasi
BACKGROUND: peripheral neuropathy is the most common problem of diabetes. Neuropathy leads to lower extremity somatosensory deficits and postural instability in these patients. However, there are not sufficient evidences for improving postural control in these patients. AIM: To investigate the effects of transcutaneous electrical nerve stimulation (TENS) on postural control in patients with diabetic neuropathy. METHODS: Twenty eighth patients with diabetic neuropathy (40-55 Y/O) participated in this RCT study...
June 9, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28619097/adipose-tissue-derived-stromal-vascular-fraction-in-regenerative-medicine-a-brief-review-on-biology-and-translation
#9
REVIEW
Pablo Bora, Anish S Majumdar
Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs). Recently, both SVF and ADSCs have gained wide-ranging translational significance in regenerative medicine. Initially used for cosmetic breast enhancement, this mode of treatment has found use in many diseases involving immune disorders, tissue degeneration, and ischaemic conditions. In this review, we try to address several important aspects of this field, outlining the biology, technology, translation, and challenges related to SVF- and ADSC-based therapies...
June 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28618748/evaluation-of-polyneuropathy-and-associated-risk-factors-in-children-with-type-1-diabetes-mellitus
#10
Hande Türkyilmaz, Orkide Güzel, Selvinaz Edizer, Aycan Ünalp
BACKGROUND/AIM: Diabetes mellitus (DM) is one of the most common metabolic diseases seen in the world today. Diabetic neuropathy (DN) is a chronic complication of the disease that is rarely reported in children, since it has a relatively longer latency period. Our main objective in this study is to determine the incidence rate of DN in pediatric DM patients and assess the risk factors associated with DN. MATERIALS AND METHODS: Data from 111 patients from January 2011 to May 2014 were reviewed in a retrospective manner...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618325/early-short-term-intensive-multidisciplinary-diabetes-care-a-ten-year-follow-up-of-outcomes
#11
Zhong Zhi Shen, Yu Yao Huang, Ching Jung Hsieh
OBJECTIVES: To evaluate the outcome of an early short-term intensive diabetic care program followed by a regular out-patient shared-care education program. METHODS: We retrospectively reviewed the medical charts of 196 patients newly diagnosed with type 2 diabetes mellitus (DM) who were admitted to the hospital for intensive multidisciplinary interventions. For comparison, we also enrolled 206 patients with type 2 DM newly diagnosed but not receiving short-term intensive program...
June 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28616956/tramadol-for-neuropathic-pain-in-adults
#12
REVIEW
Rudolf Martin Duehmke, Sheena Derry, Philip J Wiffen, Rae F Bell, Dominic Aldington, R Andrew Moore
BACKGROUND: This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli...
June 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28616922/-clinical-characteristics-of-patients-with-type-2-diabetes-mellitus-and-obstructive-sleep-apnea-syndrome
#13
Cui-Xia Tan, Yun Gao, Chun Wang, Yan Li, Xiao-Bing Feng, Yang-Fan Cheng, Yang Zhang, Xing-Wu Ran
OBJECTIVES: To compare the clinical characteristics and prevalence of chronic complications in type 2 diabetes mellitus (T2DM) patients with various degrees of obstructive sleep apnea syndrome (OSAS). METHODS: A total of 170 patients with T2DM and OSAS were enrolled in this study. These participants were divided into three groups with low, medium and high apnea-hypopnea index (AHI), respectively. The demographic characteristics, biochemical indicators and chronic complications of the patients in the three groups were compared...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28616394/new-method-of-sudomotor-function-measurement-to-detect-microvascular-disease-and-sweat-gland-nerve-or-unmyelinated-c-fiber-dysfunction-in-adults-with-retinopathy
#14
John E Lewis, Steven E Atlas, Ammar Rasul, Ashar Farooqi, Laura Lantigua, Oscar L Higuera, Andrea Fiallo, Lianette Laria, Renata Picciani, Ken Wals, Zohar Yehoshua, Armando Mendez, Janet Konefal, Sharon Goldberg, Judi Woolger
BACKGROUND: Diabetes-associated microvascular complications such as retinopathy and neuropathy often lead to end-organ and tissue damage. Impaired skin microcirculation often precedes the detection of other advanced diabetic complications. The ANS-1 system contains a redesigned sympathetic skin response (ANS-1 SSR) device that measures sudomotor function, a photoplethysmography sensor, and a blood pressure device to comprehensively assess cardiac autonomic neuropathy and endothelial dysfunction...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28615513/thioredoxin-plays-a-key-role-in-retinal-neuropathy-prior-to-endothelial-damage-in-diabetic-mice
#15
Xiang Ren, Chen Li, Junli Liu, Chenghong Zhang, Yuzhen Fu, Nina Wang, Haiying Ma, Heyuan Lu, Hui Kong, Li Kong
Diabetes is a chronic metabolic syndrome that results in changes in carbohydrate, lipid and protein metabolism. With diabetes for a long time, it increases the risk of diabetic retinopathy (DR) and long-term morbidity and mortality. Moreover, emerging evidence suggests that neuron damage occurs earlier than microvascular complications in DR patients, but the underlying mechanism is unclear. We investigated diabetes-induced retinal neuropathy and elucidated key molecular events to identify new therapeutic targets for the clinical treatment and prevention of DR...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614534/peripheral-polyneuropathy-in-severely-obese-patients-with-metabolic-syndrome-but-without-diabetes-association-with-low-hdl-cholesterol
#16
Otto Henrique Nienov, Luciana Matte, Lisiane Stefani Dias, Helena Schmid
Introduction: The purpose of this study was to evaluate the prevalence of peripheral polyneuropathy (PPN) in subjects with grade II and III obesity (Ob-II,III) and metabolic syndrome (MetS) but without diabetes and to investigate possible associated factors. Method: A cross-sectional study was performed in non-diabetic Ob-II,III,MetS patients using the Michigan Neuropathy Screening Instrument (MNSI) to assess the presence of PPN. Results: A total of 24 of 218 non-diabetic Ob-II,III,MetS patients had PPN...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28611204/clinical-and-genome-wide-analysis-of-cisplatin-induced-peripheral-neuropathy-in-survivors-of-adult-onset-cancer
#17
M Eileen Dolan, Omar El Charif, Heather E Wheeler, Eric R Gamazon, Shirin Ardeshir-Rouhani-Fard, Patrick Monahan, Darren R Feldman, Robert Hamilton, David J Vaughn, Clair Beard, Chunkit Fung, Sophie D Fossa, Daniel L Hertz, Taisei Mushiroda, Michiaki Kubo, Lawrence H Einhorn, Nancy Cox, Lois Travis
Our purpose was to characterize the clinical influences, genetic risk factors, and gene mechanisms contributing to persistent cisplatin-induced peripheral neuropathy (CisIPN) in testicular cancer survivors (TCS).<br /><br />Experimental Design: <p>TCS given cisplatin-based therapy completed the validated EORTC QLQ-CIPN20 questionnaire. An ordinal CisIPN phenotype was derived and associations with age, smoking, excess drinking, hypertension, body mass index, diabetes, hypercholesterolemia, cumulative cisplatin dose, and self-reported health were examined for 680 TCS...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28608142/erratum-to-antinociceptive-interaction-of-gabapentin-with-minocycline-in-murine-diabetic-neuropathy
#18
H F Miranda, F Sierralta, V Jorquera, P Poblete, J C Prieto, V Noriega
No abstract text is available yet for this article.
June 12, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28606850/the-impact-of-%C3%AE-lipoic-acid-on-cell-viability-and-expression-of-nephrin-and-znf580-in-normal-human-podocytes
#19
Ulrike Leppert, Allan Gillespie, Miriam Orphal, Karen Böhme, Claudia Plum, Kaj Nagorsen, Janine Berkholz, Reinhold Kreutz, Andreas Eisenreich
Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown to exhibit protective effects on diabetic nephropathy in vivo. However, the effect of α-LA on hPC under non-diabetic conditions is unknown. Therefore, we analyzed the impact of α-LA on cell viability and expression of nephrin and zinc finger protein 580 (ZNF580) in normal hPC in vitro...
June 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28606476/vitamin-d-supplement-ameliorates-hippocampal-metabolism-in-diabetic-rats
#20
Feng Guo, Hao Yue, Lei Wang, Chenzhao Ding, Lina Wu, Yang Wu, Fabao Gao, Guijun Qin
Vitamin D deficiency induced by diabetes mellitus is tightly associated with neurodegenerative diseases, but the mechanism is still unknown. Endoplasmic reticulum stress (ER stress) is involved in hippocampal lesion and promote diabetic neuropathy, so we focus on the effects of 1, 25-dihydroxy vitamin D3 on ER stress in hippocampus of diabetic rats. Streptozotocin (STZ)-induced diabetic rats were administrated with different doses of vitamin D and divided into 3 groups: high, low, and blank, compared to wild-type rats which were received the same treatment...
June 9, 2017: Biochemical and Biophysical Research Communications
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