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MTS cell penetrating motif

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https://www.readbyqxmd.com/read/15951331/prevention-of-nf-kappab-activation-in-vivo-by-a-cell-permeable-nf-kappab-inhibitor-peptide
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Ana L Mora, John LaVoy, Martha McKean, Arlene Stecenko, Kenneth L Brigham, Richard Parker, Mauricio Rojas
The NF-kappaB/Rel transcription factor family plays a central role in coordinating the expression of a variety of genes that regulate stress responses, immune cell activation, apoptosis, proliferation, differentiation, and oncogenic transformation. Interventions that target the NF-kappaB pathway may be therapeutic for a variety of pathologies, especially immune/inflammatory diseases. Using membrane translocating sequence (MTS) technology, we developed a cell-permeable dominant inhibitor of NF-kappaB activation, termed IkappaBalpha-(DeltaN)-MTS...
October 2005: American Journal of Physiology. Lung Cellular and Molecular Physiology
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