Hui-Feng Zhang, Huan Yu, Shuang-Xue Pan, Chuang Zhang, Ying-Hui Ma, Yan-Fei Zhang, Li-Li Zuo, Cheng-Yi Hao, Xiao-Ying Lin, Hao Geng, Di Wu, Shang-Qiang Mu, Wei-Lun Yu, Nian-Qiu Shi
Nanotherapies, valued for their high efficacy and low toxicity, frequently serve as antitumor treatments, but do not readily penetrate deep into tumor tissues and cells. Here we developed an improved tumor-penetrating peptide (TPP)-based drug delivery system. Briefly, the established TPP iNGR was modified to generate a linear NGR peptide capable of transporting nanotherapeutic drugs into tumors through a CendR pathway-dependent, neuropilin-1 receptor-mediated process. Although TPPs have been reported to reach intended tumor targets, they often fail to penetrate cell membranes to deliver tumoricidal drugs to intracellular targets...
March 15, 2024: Biomaterials Science