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Childhood asthma

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https://www.readbyqxmd.com/read/28632934/a-prospective-microbiome-wide-association-study-of-food-sensitization-and-food-allergy-in-early-childhood
#1
Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard Bacharier, Robert Zeiger, Erica Sodergren, George M Weinstock, Diane R Gold, Scott T Weiss, Augusto A Litonjua
BACKGROUND: Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. METHODS: Intestinal microbiome samples were collected at age 3-6 months in children participating in the follow-up phase of an interventional trial of high dose Vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28632874/screening-for-obesity-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#2
David C Grossman, Kirsten Bibbins-Domingo, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea, orthopedic problems, and adverse cardiovascular and metabolic outcomes (eg, high blood pressure, abnormal lipid levels, and insulin resistance)...
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28629745/exposure-to-non-microbial-n-glycolylneuraminic-acid-protects-farmers-children-against-airway-inflammation-and-colitis
#3
Remo Frei, Ruth Ferstl, Caroline Roduit, Mario Ziegler Dipl-Ing, Elisa Schiavi, Weronika Barcik, Noelia Rodriguez-Perez, Oliver F Wirz, Marcin Wawrzyniak, Benoit Pugin, Dirk Nehrbass, Marek Jutel, Sylwia Smolinska, Patrycja Konieczna, Christian Bieli, Susanne Loeliger, Marco Waser, Göran Pershagen, Josef Riedler, Martin Depner, Bianca Schaub, Jon Genuneit, Harald Renz, Juha Pekkanen, Anne M Karvonen, Jean-Charles Dalphin, Marianne van Hage, Gert Doekes, Mübeccel Akdis, Charlotte Braun-Fahrländer, Cezmi A Akdis, Erika von Mutius, Liam O'Mahony, Roger P Lauener
BACKGROUND: Childhood exposure to a farm environment has been shown to protect against the development of inflammatory diseases such as allergy, asthma, and inflammatory bowel disease. OBJECTIVE: We sought to investigate whether besides exposure to microbes also exposure to structures of non-microbial origin such as the sialic acid N-Glycolylneuraminic acid (Neu5Gc) may play a significant role. METHODS: Exposure to Neu5Gc was evaluated by quantifying anti-Neu5Gc antibody levels in the sera of children enrolled in two farm studies: the PARSIFAL study (n=299) and the PASTURE birth cohort (cord blood (n=836), 1 year (n=734), 4...
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28623898/early-life-gut-microbial-colonization-shapes-th1-th2-balance-in-asthma-model-in-balb-c-mice
#4
Li-Juan Qian, Shu-Min Kang, Jia-Li Xie, Li Huang, Quan Wen, Yuan-Yuan Fan, Li-Jun Lu, Li Jiang
BACKGROUND: We aimed to investigate the effect of early-life diverse microbial exposures on gut microbial colonization in an OVA-induced asthma model in BALB/c mice. METHODS: BALB/c mice were divided into 4 groups: A, offsprings were kept in a SPF environment during fetal, lactation, and childhood periods; B, offsprings were kept in the SPF environment during fetal and lactation periods, and kept in the general environment during childhood; C, offsprings were kept in the SPF environment only during fetal period, and then kept in the general environment; and D, offsprings were kept in the general environment during whole periods...
June 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28619712/targeting-acetylcholine-receptor-m3-prevents-the-progression-of-airway-hyperreactivity-in-a-mouse-model-of-childhood-asthma
#5
Kruti R Patel, Yan Bai, Kenneth G Trieu, Juliana Barrios, Xingbin Ai
Asthma often progresses into adulthood from early-life episodes of adverse environmental exposures. However, how the injury to developing lungs contributes to the pathophysiology of persistent asthma remains poorly understood. In this study, we identified an age-related mechanism along the cholinergic nerve-airway smooth muscle (ASM) axis that underlies prolonged airway hyperreactivity (AHR) in mice. We showed that ASM continued to mature until ∼3 wk after birth. Coinciding with postnatal ASM maturation, there was a critical time window for the development of ASM hypercontractility after cholinergic stimulation...
June 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28619649/the-school-inner-city-asthma-intervention-study-design-rationale-methods-and-lessons-learned
#6
Wanda Phipatanakul, Petros Koutrakis, Brent A Coull, Choong-Min Kang, Jack M Wolfson, Stephen T Ferguson, Carter R Petty, Mihail Samnaliev, Amparito Cunningham, William J Sheehan, Jonathan M Gaffin, Sachin N Baxi, Peggy S Lai, Perdita Permaul, Liming Liang, Peter S Thorne, Gary Adamkiewicz, Kasey J Brennan, Andrea A Baccarelli, Diane R Gold
Asthma is the most common chronic disease of childhood in the United States, causes significant morbidity, particularly in the inner-city, and accounts for billions of dollars in health care utilization. Home environments are established sources of exposure that exacerbate symptoms and home-based interventions are effective. However, elementary school children spend 7 to 12h a day in school, primarily in one classroom. From the observational School Inner-City Asthma Study we learned that student classroom-specific exposures are associated with worsening asthma symptoms and decline in lung function...
June 12, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28618023/is-the-atopic-march-related-to-confounding-by-genetics-and-early-life-environment-a-systematic-review-of-sibship-and-twin-data
#7
REVIEW
Sabria J Khan, Shyamali C Dharmage, Melanie C Matheson, Lyle C Gurrin
A popular hypothesis known as the atopic march proposes a set of sequential allergy and respiratory disorders in early childhood contributes enormously to the burden of disease in developed countries. Although the concept of the atopic march has been refined and strengthened by many cross-sectional and longitudinal studies linking eczema as the initial manifestation with progression to hay fever and then asthma, there is yet no definitive proof that the atopic march is the primary causal factor in childhood allergic disease...
June 15, 2017: Allergy
https://www.readbyqxmd.com/read/28617244/continuity-of-care-in-infancy-and-early-childhood-health-outcomes
#8
Elizabeth Enlow, Molly Passarella, Scott A Lorch
BACKGROUND AND OBJECTIVES: Continuity of care is a key aspect of the patient-centered medical home and improves pediatric outcomes. Health care reform requires high-quality data to demonstrate its continued value. We hypothesized that increased provider continuity in infancy will reduce urgent health care use and increase receipt of preventive services in early childhood. METHODS: Continuity, using the Usual Provider of Care measure, was calculated across all primary care encounters during the first year of life in a prospectively-constructed cohort of 17 773 infants receiving primary care from birth through 3 years at 30 clinics...
June 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28614408/schistosoma-japonicum-infection-downregulates-house-dust-mite-induced-allergic-airway-inflammation-in-mice
#9
Sugan Qiu, Xiaolin Fan, Yingying Yang, Panpan Dong, Wei Zhou, Yongliang Xu, Yonghua Zhou, Fukun Guo, Yi Zheng, Jun-Qi Yang
The "hygiene hypothesis" is a theory try to explain the dramatic increases in the prevalence of autoimmune and allergic diseases over the past two to three decades in developed countries. According to this theory, reduced exposure to parasites and microorganisms in childhood is the main cause for the increased incidences of both T helper 1 (Th1)-mediated autoimmunity and Th2-mediated allergy. In this study, we investigated the impact of Schistosoma japonicum infection on the allergic airway inflammation induced by repeated intracheal inoculations of house dust mites (HDM), which is a Th17 and neutrophils dominant murine asthma model, mimicking severe asthma...
2017: PloS One
https://www.readbyqxmd.com/read/28604080/association-of-childhood-obesity-and-the-immune-system-a-systematic-review-of-reviews
#10
Roya Kelishadi, Mohammad Roufarshbaf, Sina Soheili, Farzaneh Payghambarzadeh, Mohsen Masjedi
The growing prevalence of childhood obesity has become a serious health problem over the past decades. As the immune system is greatly affected by excess weight, in this review of reviews, we discuss the findings of review articles about the relationship between childhood/maternal obesity and children's immune system. We searched English-language articles in PubMed, Scopus, ISI Thomson Reuters, and Google Scholar databases. All relevant reviews, either systematic or narrative, were retrieved. Then their quality was assessed by using the Assessment of Multiple Systematic Reviews and International Narrative Systematic Assessment tools, respectively...
June 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28601856/methodological-issues-in-association-of-allergic-rhinitis-and-sinusitis-with-childhood-asthma-authors-reply
#11
Meenu Singh, Rashmi Ranjan Das
No abstract text is available yet for this article.
May 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28601855/methodological-issues-in-association-of-allergic-rhinitis-and-sinusitis-with-childhood-asthma
#12
M D Bashar, Kamal Kishore
No abstract text is available yet for this article.
May 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28600777/psychoneuroimmunology-developments-in-stress-research
#13
REVIEW
Rainer H Straub, Maurizio Cutolo
Links between the central nervous stress system and peripheral immune cells in lymphoid organs have been detailed through 50 years of intensive research. The brain can interfere with the immune system, where chronic psychological stress inhibits many functions of the immune system. On the other hand, chronic peripheral inflammation-whether mild (during aging and psychological stress) or severe (chronic inflammatory diseases)-clearly interferes with brain function, leading to disease sequelae like fatigue but also to overt psychiatric illness...
June 9, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28599075/increased-risk-of-asthma-in-overweight-children-born-large-for-gestational-age
#14
Leonardo A Pinto, Stefano Guerra, Josep M Anto, Dirkje Postma, Gerard H Koppelman, Johan C de Jongste, Ulrike Gehring, Henriette A Smit, Alet Wijga
BACKGROUND: Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children...
June 9, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28592396/prevalence-of-and-risk-factors-for-childhood-asthma-rhinitis-and-eczema-in-hong-kong-proposal-for-a-cross-sectional-survey
#15
So Lun Lee, Yu Lung Lau, Hing Sang Wong, Linwei Tian
BACKGROUND: Previous studies have shown that particulate matter is a major problem in indoor air quality in Hong Kong schools, but little has been done to assess its relationship with health indicators in the children attending those schools. Our study aims to address this research gap by collecting aerosol data in schools to examine the link between different air pollutants with childhood respiratory health. It is important to explore whether or not the prevalence of asthma, allergic rhinoconjunctivitis, and eczema are increasing in local children...
June 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28590769/associations-of-genetic-polymorphisms-relevant-to-metabolic-pathway-of-vitamin-d3-with-development-and-prognosis-of-childhood-bronchial-asthma
#16
Ying Zhang, Zhansheng Wang, Tongshuai Ma
This study was aimed at investigating the correlation between genetic polymorphisms relevant to metabolic pathway of vitamin D3 (VD3) and susceptibility to childhood bronchial asthma. Altogether 143 childhood patients with bronchial asthma and 143 healthy children of Chinese Han ethnicity were enrolled in this study. The key single-nucleotide polymorphisms (SNPs) were identified by HaploView 4.2 software and selected from previous investigations. Genomic DNAs were isolated from peripheral blood samples by using TaqMan Blood DNA kits...
June 7, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28590266/sex-differences-in-aortic-augmentation-index-in-adolescents
#17
Jennifer Y Barraclough, Frances L Garden, Brett Toelle, Shamus O'Meagher, Guy B Marks, Christopher T Cowell, David S Celermajer, Julian G Ayer
BACKGROUND: Augmentation index (AIx) is a noninvasive measure of pulse wave reflection. AIx is associated with cardiovascular disease. Adult women have a higher AIx than men, but the factors determining this sex-related difference remain to be determined. METHODS: To examine factors associated with AIx in adolescents, participants in the Childhood Asthma Prevention Study, followed from birth, were assessed at age 14 years, with AIx standardized to a heart rate of 75/min (AIx_75) and pulse wave velocity...
June 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28589108/asthma-and-allergic-rhinitis-correlation-in-palm-tree-workers-of-jahrom-city-in-2016
#18
Mohammad Amin Farahmand Fard, Narges Khanjani, Aliasghar Arabi Mianroodi, Ahad Ashrafi Asgarabad
INTRODUCTION: Allergic rhinitis and asthma can be related to occupation. The present study aimed to investigate the correlation between asthma or allergic rhinitis and employment in the palm tree gardens of Jahrom, Iran. MATERIALS AND METHODS: This was a cross-sectional study including 50 palm tree garden workers and a control group of 50 office employees. Data collection included demographics, as well as standard International Study of Asthma and Allergies in Childhood (ISAAC) and A New Symptom-Based Questionnaire for Predicting the Presence of Asthma (ASQ) questionnaires...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28588827/a-case-of-a-pulmonary-artery-sling-misdiagnosed-as-refractory-asthma-for-20%C3%A2-years
#19
Toshihide Inui, Hideyasu Yamada, Norihito Hida, Hideo Terashima, Takefumi Saito, Nobuyuki Hizawa
We report the case of a 25-year-old woman with a pulmonary artery sling who was misdiagnosed as having childhood-onset refractory asthma for approximately 20 years. The use of computed tomography may be useful for diagnosing this rare condition.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28585768/allergic-rhinitis-rather-than-asthma-is-a-risk-factor-for-dental-caries
#20
Chun-Yi Chuang, HaiLun Sun, Min Sho Ku
OBJECTIVES: The association between AS (asthma) and dental caries is controversial, while that between AR (allergic rhinitis) and caries has not been established. This study aimed to verify the relationship among AR, AS, and dental caries. DESIGN: retrospective cohort study. SETTING: Data from Health Insurance Database of the Taiwan's National Health Insurance Research. DATABASE: Participants: Nine thousand and thirty eight children born in 2004 were obtained...
June 6, 2017: Clinical Otolaryngology
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