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Childhood asthma

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https://www.readbyqxmd.com/read/29785881/variants-in-genes-coding-for-glutathione-s-transferases-and-asthma-outcomes-in-children
#1
Steve Turner, Ben Francis, Nuha Wani, Susanne Vijverberg, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Esteban G Burchard, Simon Kebede Merid, Erik Melén, Anke H Maitland-van der Zee, On Behalf Of The Pharmacogenomics In Childhood Asthma Consortium
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29785060/cost-effectiveness-of-vitamin-c-supplementation-for-pregnant-smokers-to-improve-offspring-lung-function-at-birth-and-reduce-childhood-wheeze-asthma
#2
Leah Yieh, Cindy T McEvoy, Scott W Hoffman, Aaron B Caughey, Kelvin D MacDonald, Dmitry Dukhovny
OBJECTIVE: To determine the implications of supplemental vitamin C for pregnant tobacco smokers and its effects on the prevalence of pediatric asthma, asthma-related mortality, and associated costs. STUDY DESIGN: A decision-analytic model built via TreeAge compared the outcome of asthma in a theoretical annual cohort of 480,000 children born to pregnant smokers through 18 years of life. Vitamin C supplementation (500 mg/day) with a standard prenatal vitamin was compared to a prenatal vitamin (60 mg/day)...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29784755/intergenerational-associations-of-parent-adverse-childhood-experiences-and-child-health-outcomes
#3
Félice Lê-Scherban, Xi Wang, Kathryn H Boyle-Steed, Lee M Pachter
BACKGROUND: Adverse childhood experiences (ACEs) robustly predict future morbidity and mortality. Researchers are just beginning to investigate intergenerational effects. We hypothesize there are intergenerational associations between parent ACE exposure and worse child health, health behaviors, and health care access and use. METHODS: We linked data from 2 population-based cross-sectional telephone surveys in Philadelphia, Pennsylvania, that were used to ask parents about their past exposure to ACEs and their child's health, respectively...
May 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/29781915/childhood-asthma-disparities-in-chicago-developing-approaches-to-health-inequities
#4
Molly A Martin, Melissa Gutierrez Kapheim, Kim Erwin, Stacy Ignoffo, Kate McMahon, Amy OʼRourke, Lynn B Gerald, Meredith Barrett, Valerie G Press, Houshang Darabi, Jerry A Krishnan
We conducted a needs assessment to develop an evidence-based, locally tailored asthma care implementation plan for high-risk children with asthma in Chicago. Our team of health policy experts, clinicians, researchers, and designers included extensive stakeholder engagement (N = 162) in a mixed-methods community needs assessment. Results showed the lines of communication and collaboration across sectors were weak; caregivers were the only consistent force and could not always manage this burden. A series of recommendations for interventions and how to implement and measure them were generated...
July 2018: Family & Community Health
https://www.readbyqxmd.com/read/29779923/a-viral-vectored-rsv-vaccine-induces-long-lived-humoral-immunity-in-cotton-rats
#5
Jessica L Grieves, Zhiwei Yin, Adolfo Garcia-Sastre, Ignacio Mena, Mark E Peeples, Heidi P Risman, Hannah Federman, Marvin J Sandoval, Russell K Durbin, Joan E Durbin
Human respiratory syncytial virus (RSV) is the leading cause of lower airway disease in infants worldwide and repeatedly infects immunocompetent individuals throughout life. Severe lower airway RSV infection during infancy can be life-threatening, but is also associated with important sequelae including development of asthma and recurrent wheezing in later childhood. The basis for the inadequate, short-lived adaptive immune response to RSV infection is poorly understood, but it is widely recognized that RSV actively antagonizes Type I interferon (IFN) production...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29771597/concordance-between-survey-reported-childhood-asthma-and-linked-medicaid-administrative-records
#6
Benjamin Zablotsky, Lindsey I Black
OBJECTIVE: Agreement between administrative and survey data has been shown to vary by the condition of interest and there is limited research dedicated to parental report of asthma among children. The current study assesses the concordance between parent-reported asthma from the National Health Interview Survey (NHIS) with Medicaid administrative claims data among linkage eligible children from the NHIS. METHODS: Medicaid Analytic eXtract (MAX) files from the Centers for Medicare & Medicaid Services (CMS) (years 2000-2005) were linked to participants of the NHIS (years 2001-2005)...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29769601/urinary-polycyclic-aromatic-hydrocarbon-metabolites-and-adult-asthma-a-case-control-study
#7
Xiji Huang, Yun Zhou, Xiuqing Cui, Xiaojie Wu, Jing Yuan, Jungang Xie, Weihong Chen
Polycyclic aromatic hydrocarbons (PAHs) exposure was reported to be associated with childhood asthma. However, the quantitative relationship between PAHs exposure and adult asthma and possible inflammatory pathways are less clear. We aimed to investigate potential associations between urinary PAHs metabolites and adult asthma. We enrolled 507 adult asthma cases and 536 matched controls. The concentrations of 12 urinary PAHs metabolites and plasma cytokines of interleukin (IL)-9 and eotaxin were measured. Potential associations between urinary PAHs metabolites and adult asthma were analyzed by logistic regression...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768461/pet-keeping-in-childhood-and-asthma-and-allergy-among-children-in-tianjin-area-china
#8
Shugang Luo, Yuexia Sun, Jing Hou, Xiangrui Kong, Pan Wang, Qingnan Zhang, Jan Sundell
This study aims to find out the relationship between pet keeping in childhood and asthma and allergy among children aged 0-8 years old in Tianjin, China. Parental or guardians reports of 7360 children were analyzed. 1490 (21.6%) families kept pets at the time of the survey (current), among them 4.0% cats, and 14.7% dogs. For the first year of life of children (early), 1196 (18.4%) families kept pets, and among them 3.2% cats, and 13.7% dogs. Exposure to a pet in early childhood significantly increased the risk of current wheeze, current dry cough, and diagnosed rhinitis...
2018: PloS One
https://www.readbyqxmd.com/read/29762208/prevalence-of-atopic-dermatitis-and-pattern-of-drug-therapy-in-malaysian-children
#9
Yi-Yeong Goh, Fazlollah Keshavarzi, Yik Ling Chew
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing, noncontagious skin inflammation characterized by dry skin and itch. Mutation in filaggrin gene leads to defective skin barrier, allowing entry of allergen and eliciting immunological response. OBJECTIVES: The aims of this study were to investigate the prevalence of AD in Malaysian children and to understand the pattern of drug therapy. Such information could be useful to establish the relationship between ethnicity and family history of atopy and the development of associated signs and symptoms...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29758111/genetic-profiles-of-transcriptomic-clusters-of-childhood-asthma-determine-specific-severe-subtype
#10
Y-L Yeh, M-W Su, B-L Chiang, Y-H Yang, C-H Tsai, Y L Lee
BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. OBJECTIVE: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients. METHODS: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29757881/health-and-educational-implications-of-prematurity-in-the-united-states-national-survey-of-children-s-health-2011-2012-data
#11
Michelle M Kelly
BACKGROUND AND PURPOSE: Preterm birth is a significant public health issue, with children born prematurely experiencing educational and health difficulties throughout childhood. The aim of the descriptive secondary data analysis was to compare health implications and educational experiences in children born prematurely compared with children born at term. METHODS: The 2011/2012 National Survey of Children's Health data set was explored using separate chi-square tests of homogeneity to investigate differences in the occurrence of chronic health conditions and educationally relevant outcomes: individualized family services plan/individualized education plan (IFSP/IEP), and grade repetition between children born prematurely compared with those born at term...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29755048/school-based-interprofessional-asthma-self-management-education-program-for-middle-school-students-a-feasibility-trial
#12
Ellen B Buckner, Donna J Copeland, Kristina S Miller, Timothy Op Holt
BACKGROUND: Asthma is the most common chronic disease among school-aged children under 18 years of age and is a major cause of morbidity, loss of school days, and increased hospitalizations. Asthma disproportionately affects low-income, minority youth in Alabama. The benefits of improving asthma control and self-management have significance for improving health, preventing disease, and reducing health disparities by addressing social, behavioral, environmental, economic, and medical determinants of health...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29750772/the-ins-and-outs-of-an-outside-in-view-of-allergies-atopic-dermatitis-and-allergy-prevention
#13
Marcus Shaker, Robert G P Murray, Julianne A Mann
PURPOSE OF REVIEW: The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march. RECENT FINDINGS: Atopic dermatitis is characterized by skin barrier defects (such as mutations in filaggrin), intrinsic proallergic T-helper cell 2 immune dysregulation, and skin microbiome alterations. These factors promote the development of food allergy and asthma...
May 9, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29747980/taming-asthma-in-school-aged-children-a-comprehensive-review
#14
Ahmad Salaheddine Naja, Perdita Permaul, Wanda Phipatanakul
Asthma is the most common chronic disease of childhood and the leading cause of childhood morbidity as measured by school absences, emergency department visits, and hospitalizations. Multiple factors play a role in the development, treatment and prevention of childhood asthma including racial/ethnic and socioeconomic disparities, both the home and school environments, and medication use. The goals of this review are to summarize these aspects of asthma in school-aged children and to present an updated review of medications as it relates to treatment strategies that will help in the care of these children...
May 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29747970/challenges-in-childhood-asthma-mortality-persist-despite-advances-in-care
#15
EDITORIAL
Anne L Fuhlbrigge
No abstract text is available yet for this article.
May 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29739688/resources-to-handle-childhood-asthma-in-spain-the-role-of-plans-and-guides-and-the-participation-of-nurses
#16
M I Úbeda-Sansano, A Cano-Garcinuño, S Rueda-Esteban, M Praena-Crespo
BACKGROUND: Describe the assistance provided to asthmatic patients by Primary Care Paediatricians (PCP) in Spain and the material and human resources available for diagnosis and follow-up. METHODS: A cross-sectional descriptive study using an on-line survey, sent to PCP regarding the availability of diagnostic resources, carrying out programmed and educational activities, collaboration of nursing staff and their relationship with existing institutional plans to care for children with asthma...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29737224/associations-between-childhood-biomedical-factors-maternal-smoking-personality-traits-body-and-mass-index-and-the-prevalence-of-asthma-in-adulthood
#17
Helen Cheng, Scott Montgomery, Luke Treglown, Adrian Furnham
OBJECTIVE: The study set out to investigate socio-economic, biomedical, health and behavioural and psychological factors in childhood and adulthood associated with the prevalence of asthma in adulthood, drawing data from The National Child Development Studies (NCDS), a birth cohort in the UK. DESIGN: The National Child Development Study, a nationally representative sample of 17,415 babies born in Great Britain in 1958 and followed up at 7, 11, 33 and 50 years was used...
May 8, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29736958/benefits-of-pulmonary-rehabilitation-in-pediatric-asthma
#18
Stephen Kirkby, Allison Rossetti, Don Hayes, Elizabeth Allen, Shahid Sheikh, Benjamin Kopp, Alpa Patel
INTRODUCTION: There are limited studies evaluating the role of pulmonary rehabilitation (PR) in pediatric asthma. METHODS: A retrospective chart review was performed of all pediatric patients with a diagnosis of asthma enrolled in PR. Demographics, medications, and clinical records were reviewed. In addition, PFTs, 6-min walk test (6MWT), and patient/parent symptom and quality of life surveys before and after PR were evaluated. RESULTS: A total of 38 patients were enrolled in PR; 18 (47%) female and 20 (53%) male...
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29736253/associations-of-physical-activity-with-childhood-asthma-a-population-study-based-on-the-who-health-behaviour-in-school-aged-children-survey
#19
Lene Lochte, Poul Erik Petersen, Kim G Nielsen, Anette Andersen, Thomas A E Platts-Mills
Background: Asthma in paediatric populations is one of the highest public health concerns. In this study of children and adolescents, we hypothesized that low levels of physical activity (PA) would show associations with asthma that vary by asthma outcome. The objective was to assess whether PA was associated with ever asthma and/or current asthma . Methods: Analyses were based on 4824 Danish schoolchildren aged 11-15 years old (48.7% boys) participating in the HBSC survey...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29735984/vegetation-diversity-protects-against-childhood-asthma-results-from-a-large-new-zealand-birth-cohort
#20
Geoffrey H Donovan, Demetrios Gatziolis, Ian Longley, Jeroen Douwes
We assessed the association between the natural environment and asthma in 49,956 New Zealand children born in 1998 and followed up until 2016 using routinely collected data. Children who lived in greener areas, as measured by the normalized difference vegetation index, were less likely to be asthmatic: a 1 s.d. increase in normalized difference vegetation index was associated with a 6.0% (95% CI 1.9-9.9%) lower risk of asthma. Vegetation diversity was also protective: a 1 s.d. increase in the number of natural land-cover types in a child's residential meshblock was associated with a 6...
May 7, 2018: Nature Plants
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