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Keywords Advanced lung cancer inflammat...

Advanced lung cancer inflammation index

https://read.qxmd.com/read/38523686/prognostic-nutritional-index-predicts-efficacy-and-immune-related-adverse-events-of-first-line-chemoimmunotherapy-in-patients-with-extensive-stage-small-cell-lung-cancer
#1
JOURNAL ARTICLE
Baishen Zhang, Jing Chen, Hui Yu, Meichen Li, Muyan Cai, Likun Chen
BACKGROUND: Currently, there is a lack of well-established markers to predict the efficacy of chemoimmunotherapy in small-cell lung cancer (SCLC). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) are associated with prognosis in several tumors, whereas their predictive role in SCLC remains unclear. METHODS: A retrospective study was conducted at Sun Yat-sen University Cancer Center, involving extensive-stage SCLC (ES-SCLC) patients who received first-line chemoimmunotherapy between January 2020 and December 2021...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38441779/development-and-validation-of-a-prognostic-nomogram-model-in-locally-advanced-nsclc-based-on-metabolic-features-of-pet-ct-and-hematological-inflammatory-indicators
#2
JOURNAL ARTICLE
Congjie Wang, Jian Fang, Tingshu Jiang, Shanliang Hu, Ping Wang, Xiuli Liu, Shenchun Zou, Jun Yang
BACKGROUND: We combined the metabolic features of 18 F-FDG-PET/CT and hematological inflammatory indicators to establish a predictive model of the outcomes of patients with locally advanced non-small cell lung cancer (LA-NSCLC) receiving concurrent chemoradiotherapy. RESULTS: A predictive nomogram was developed based on sex, CEA, systemic immune-inflammation index (SII), mean SUV (SUVmean), and total lesion glycolysis (TLG). The nomogram presents nice discrimination that yielded an AUC of 0...
March 5, 2024: EJNMMI Physics
https://read.qxmd.com/read/38425396/systemic-inflammation-response-index-and-weight-loss-as-prognostic-factors-in-metastatic-pancreatic-cancer-a-concept-study-from-the-pantheia-seom-trial
#3
JOURNAL ARTICLE
Vilma Pacheco-Barcia, Sara Custodio-Cabello, Fatima Carrasco-Valero, Magda Palka-Kotlowska, Axel Mariño-Mendez, Alberto Carmona-Bayonas, Javier Gallego, A J Muñoz Martín, Paula Jimenez-Fonseca, Luis Cabezon-Gutierrez
BACKGROUND: The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored. AIM: To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer. METHODS: The PANTHEIA-Spanish Society of Medical Oncology (SEOM) study is a multicentric (16 Spanish hospitals), observational, longitudinal, non-interventional initiative, promoted by the SEOM Real World-Evidence work group...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38390261/advanced-lung-cancer-inflammation-index-predicts-overall-survival-of-hepatocellular-carcinoma-after-hepatectomy
#4
JOURNAL ARTICLE
Yuan-Zhang Wen, Gao-Min Liu, Jia-Peng Liao, Ji-Wei Xu
AIM: Limited data are available regarding ALI's clinical relevance and prognostic value in patients with hepatocellular carcinoma (HCC) after hepatectomy. MATERIALS AND METHODS: HCC patients who received hepatectomy at the Meizhou People's Hospital from May 2011 to February 2022 were enrolled in the study cohort. The ALI was calculated as follows: ALI = BMI (kg/m2 ) × ALB (g/dL)/(absolute neutrophil count/absolute lymphocyte count). The primary outcome was overall survival (OS)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38304175/clinical-impact-of-inflammatory-and-nutrition-index-based-on-metabolic-tumor-activity-in-non%C3%A2-small-cell-lung-cancer-treated-with-immunotherapy
#5
JOURNAL ARTICLE
Koki Ito, Kousuke Hashimoto, Kyoichi Kaira, Ou Yamaguchi, Atsuto Mouri, Ayako Shiono, Yu Miura, Kunihiko Kobayashi, Hisao Imai, Ichiei Kuji, Hiroshi Kagamu
The aim of the present study was to explore the relationship between tumor metabolic glycolysis and inflammatory or nutritional status in patients with advanced non-small cell lung cancer (NSCLC) who received programmed death-1 (PD-1) blockade. A total of 186 patients were registered in the present study. All of patients underwent 18 F-FDG PET imaging before initial PD-1 blockade, and maximum standardized uptake value (SUVmax ), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were assessed as indicators of 18 F-FDG uptake...
March 2024: Oncology Letters
https://read.qxmd.com/read/38275894/early-changes-in-lipi-score-predict-immune-related-adverse-events-a-propensity-score-matched-analysis-in-advanced-non-small-cell-lung-cancer-patients-on-immune-checkpoint-blockade
#6
JOURNAL ARTICLE
Fabrizio Nelli, Agnese Fabbri, Antonella Virtuoso, Diana Giannarelli, Julio Rodrigo Giron Berrios, Eleonora Marrucci, Cristina Fiore, Enzo Maria Ruggeri
In advanced cancer patients undergoing immune checkpoint blockade, the burden of immune-related adverse events (irAEs) is high. The need for reliable biomarkers for irAEs remains unfulfilled in this expanding therapeutic field. The lung immune prognostic index (LIPI) is a noninvasive measure of systemic inflammation that has consistently shown a correlation with survival in various cancer types when assessed at baseline. This study sought to determine whether early changes in the LIPI score could discriminate the risk of irAEs and different survival outcomes in advanced non-small cell lung cancer (NSCLC) patients receiving PD-(L)1 blockade-based therapies...
January 20, 2024: Cancers
https://read.qxmd.com/read/38246904/significance-of-preoperative-evaluation-of-modified-advanced-lung-cancer-inflammation-index-for-patients-with-resectable-non-small-cell-lung-cancer
#7
JOURNAL ARTICLE
Seijiro Sato, Ryo Sezaki, Hirohiko Shinohara
OBJECTIVES: Body composition and systemic inflammation/nutrition have been identified as important clinical factors in cancer patients. The modified advanced lung cancer inflammation index (mALI), which combines body composition and systemic inflammation/nutrition, is defined as appendicular skeletal muscle index × serum albumin/neutrophil-lymphocyte ratio. This retrospective study aimed to investigate associations between preoperative mALI and surgical outcomes in non-small cell lung cancer (NSCLC) patients...
January 22, 2024: General Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38230764/biomarkers-of-peripheral-blood-neutrophil-extracellular-traps-in-the-diagnosis-and-progression-of-malignant-tumors
#8
JOURNAL ARTICLE
Min Wang, Xiaoyan Lv, Ying Wang, Yao Li, Honghong Li, Zhongjun Shen, Liyan Zhao
BACKGROUND AND AIMS: The mortality rate associated with malignant tumors remains high and there is a lack of effective diagnostic and tumor progression markers. Neutrophil extracellular traps (NETs) can promote tumor-associated thrombosis, invasive metastasis, and inflammatory responses, but there is a lack of research on the value of measuring NETs in the peripheral blood of patients with malignancies. METHODS: We included 263 patients with malignancies (55 gliomas, 101 ovarian, 64 colorectal, and 43 lung cancers) and 75 healthy controls in this study...
January 17, 2024: Cancer Medicine
https://read.qxmd.com/read/38189402/-construction-of-a-prognostic-nomogram-combining-pet-ct-metabolic-parameters-and-blood-inflammatory-markers-for-non-small-cell-lung-cancer-treated-with-first-line-chemotherapy
#9
JOURNAL ARTICLE
D Kong, L Song, Y Xiang
OBJECTIVE: To investigate the prognostic value of 18 F-FDG-PET/CT metabolic parameters and blood inflammatory markers for advanced non-small cell lung cancer (NSCLC, stage Ⅳ/ⅢB) treated with first-line chemotherapy combined with immunotherapy and construct a nomogram prediction model for NSCLC. METHODS: We retrospectively analyzed the metabolic parameters (SUVmax, MTV and TLG) and blood markers of inflammation (NLR, DNLR, PLR and SII) in 105 patients with advanced NSCLC receiving chemotherapy combined with baseline 18 F-FDG-PET/CT prior to immunotherapy from March, 2019 to June, 2021...
December 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38111710/relationship-between-advanced-lung-cancer-inflammation-index-and-long-term-all-cause-cardiovascular-and-cancer-mortality-among-type-2-diabetes-mellitus-patients-nhanes-1999-2018
#10
JOURNAL ARTICLE
Yaying Chen, Mengqian Guan, Ruiqi Wang, Xuewen Wang
BACKGROUND: Type 2 diabetes mellitus (T2DM) was a major global health threat. As a chronic low-grade inflammatory disease, the prognosis of diabetes was associated with inflammation. The advanced lung cancer inflammation index (ALI) served as a comprehensive index to assess inflammation. This study aimed to estimate the association between ALI and all-cause, cardiovascular disease (CVD), and cancer mortality in T2DM patients. METHODS: We extracted cohort data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 for analysis...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38102903/prognostic-value-of-diffuse-cancer-inflammation-index-ali-serum-neutrophil-lymphocyte-nlr-and-platelet-lymphocyte-plr-in-advanced-stage-lung-cancer
#11
JOURNAL ARTICLE
Aysen Evkan Ozturk, Berna Komurcuoglu, Gamze Kaplan Karakurt, Ozgur Ozturk
INTRODUCTION: Lung cancer is the most common type of cancer that causes death worldwide. Systemic inflammation has been shown to play a role in cancer etiopathogenesis and can be activated from oncogenic changes in cancer cells. In our study, the prognostic effects of inflammatory parameters calculated from serum were investigated in lung cancer. METHOD: One hundred fifteen patients with locally advanced and advanced lung cancer who were diagnosed in our chest diseases clinic between 2013 and 2015 were retrospectively analyzed...
December 15, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38058817/predictive-value-of-crp-combined-with-peripheral-blood-cell-ratio-for-the-prognosis-of-advanced-nsclc
#12
JOURNAL ARTICLE
Tao Wang, Caixia Zhang, Yue Gao, Hanwei Yang, Kewei Li, Jian Wang, Yi Wu
Lung cancer remains the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for the vast majority. In recent years, the interaction between inflammation and tumorigenesis has become the focus of attention, which has also confirmed the importance of inflammatory markers such as C-reactive protein (CRP) in prognosis. In this study, we explored the effects of CRP, systemic inflammatory immune index (SII), and monocyte/lymphocyte ratio (MLR) on the prognosis of patients with advanced NSCLC...
2023: American Journal of Cancer Research
https://read.qxmd.com/read/37988903/effects-of-nutritional-indices-and-inflammatory-parameters-on-patients-received-immunotherapy-for-non-small-cell-lung-cancer
#13
JOURNAL ARTICLE
Hui-Ping Ding, Yi-Qun Ling, Wei Chen, Qin Ding, Liu-Qing Xu, Yan Wu, Qiong Wang, Tian-Hao Ni, Bing-Qin He
OBJECTIVE: This research explored the relationship between a patient's nutritional state and inflammatory markers and the prognosis of their non-small cell lung cancer (NSCLC) treatment while receiving a combination of chemotherapy and immunotherapy. METHOD: This retrospective and single-center analysis included NSCLC patients who received a combination of chemotherapy and immunotherapy at the Department of Oncology at Shanghai Lung Hospital. Patients were categorized based on malnutrition, sarcopenia, sarcopenic obesity, and advanced-lung-cancer-inflammation-index (ALI) scores after collecting nutritional and inflammatory indices...
November 20, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37978441/advanced-lung-cancer-inflammation-index-combined-with-geriatric-nutritional-risk-index-predict-all-cause-mortality-in-heart-failure-patients
#14
JOURNAL ARTICLE
Tao Shi, Yan Wang, Yunzhu Peng, Meifen Wang, Yanji Zhou, Wenyi Gu, Yanyan Li, Jie Zou, Na Zhu, Lixing Chen
BACKGROUND: This study was undertaken to explore the predictive value of the advanced lung cancer inflammation index (ALI) combined with the geriatric nutritional risk index (GNRI) for all-cause mortality in patients with heart failure (HF). METHODS AND RESULTS: We enrolled 1123 patients with HF admitted to our cardiology department from January 2017 to October 2021. Patients were divided into four groups, according to the median ALI and GNRI. From the analysis of the relationship between the ALI and GNRI, we concluded that there was a mild positive linear correlation (r = 0...
November 17, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/37970209/exploring-the-implications-of-modified-advanced-lung-cancer-inflammation-index-on-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer
#15
JOURNAL ARTICLE
Abhishek Mahajan, Devendra Goyal, Ujjwal Agarwal, Vijay Patil, Shreya Shukla, Vanita Noronha, Amit Joshi, Nandini Menon, Kumar Prabhash
AIM: Sarcopenia and skeletal muscle density (SMD) have been shown to be both predictive and prognostic marker in oncology. Advanced lung cancer inflammation index (ALI) has been shown to predict overall survival (OS) in small cell lung cancer (SCLC). Computed tomography (CT) enables skeletal muscle to be quantified, whereas body mass index (BMI) cannot accurately reflect body composition. The purpose was to evaluate the prognostic value of modified ALI (mALI) using CT-determined third lumbar vertebra (L3) muscle index beyond original ALI and see the interaction between sarcopenia, SMD, neutrophil-lymphocyte ratio (NLR), ALI and mALI at baseline and post 4 cycles of chemotherapy and their effects on OS and progress free survival (PFS) in patients with advanced non-SCLC (NSCLC)...
2023: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/37969209/development-and-validation-of-a-nomogram-based-on-multiple-preoperative-immunoinflammatory-indexes-for-survival-prediction-in-patients-with-stage-ia-ib-endometrial-cancer
#16
JOURNAL ARTICLE
Nie Zhang, Hong Liu, Jiankang Yang, Fei Zhong
OBJECTIVES: To evaluate the preoperative systemic immune-inflammation index (SII), advanced lung cancer inflammation index (ALI), neutrophil to lymphocyte ratio (NLR), and prognostic nutritional index (PNI) capacity to predict the prognosis of stage IA-IB endometrial carcinoma (EC) patients after operation, and establish a nomogram model to guide clinical practice. METHODS: A total of 387 patients with EC (R0 resection, stage IA-IB) were assessed. Clinical information and the SII, NLR, ALI, and PNI values were obtained...
2023: American Journal of Translational Research
https://read.qxmd.com/read/37820973/combined-influence-of-nutritional-and-inflammatory-status-and-depressive-symptoms-on-mortality-among-us-cancer-survivors-findings-from-the-nhanes
#17
JOURNAL ARTICLE
Jiazhen Yao, Xiaohong Chen, Fang Meng, Hanzhong Cao, Xiaochen Shu
BACKGROUND: Inflammation and nutrition and depression are interrelated, and both are related to changes in mortality rates. We investigated the association of nutritional and inflammation index or depressive symptoms with the risk of all-cause mortality or cause-specific mortality among cancer survivors. METHODS: A prospective cohort of a nationally representative sample of cancer survivors, aged 40 years or older (n = 2331; weighted population, 15 248 255; 67...
October 11, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37785762/combined-modeling-of-ct-radiomics-and-clinical-parameters-for-risk-of-cachexia-in-extensive-stage-small-cell-lung-cancer-patients-treated-with-first-line-immunotherapy
#18
JOURNAL ARTICLE
R Song, B Li, Y Yao, L Wang
PURPOSE/OBJECTIVE(S): Cachexia occurs in about 60% of patients with extensive-stage small cell lung cancer (ES-SCLC), which may contribute to resistance to immunotherapy. This study integrating CT radiomics and clinical parameters aimed to identify patients at risk of developing cachexia that may be associated with prognosis in extensive-stage small cell lung cancer patients treated with first-line immunotherapy. MATERIALS/METHODS: This study retrospectively included 200 ES-SCLC patients treated with first-line immunotherapy...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37725914/clinical-utility-of-inflammatory-and-nutritious-index-as-therapeutic-prediction-of-nivolumab-plus-ipilimumab-in-advanced-nsclc
#19
JOURNAL ARTICLE
Ou Yamaguchi, Kyoichi Kaira, Hisao Imai, Atsuto Mouri, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Kunihiko Kobayashi, Hiroshi Kagamu
BACKGROUND: Biomarkers for predicting the outcome of ipilimumab plus nivolumab (Nivo-Ipi) treatment in cancer patients have not been identified. Herein, we investigated the prognostic significance of inflammatory and nutritional markers in patients with advanced non-small cell lung cancer (NSCLC) receiving Nivo-Ipi. METHODS: Our study retrospectively analyzed 101 patients with advanced NSCLC who received Nivo-Ipi at a single institution. Inflammatory and nutritional indices were correlated with patient outcomes and included the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), advanced lung cancer inflammation index (ALI), and Glasgow prognostic score (GPS)...
September 19, 2023: Oncology
https://read.qxmd.com/read/37700210/the-predictive-value-of-advanced-lung-cancer-inflammation-index-for-short-term-outcomes-and-prognosis-of-colorectal-cancer-patients-who-underwent-radical-surgery
#20
JOURNAL ARTICLE
Bin Zhang, Zi-Wei Li, Yue Tong, Chao Yuan, Xiao-Yu Liu, Zheng-Qiang Wei, Wei Zhang, Dong Peng
PURPOSE: The purpose of this study was to investigate the predictive value of advanced lung cancer inflammation index (ALI) for short-term outcomes and prognosis of colorectal cancer (CRC) patients who underwent radical surgery. METHODS: CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in our single clinical centre. Short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. Cox analysis was conducted to identify independent risk factors for OS and DFS...
September 12, 2023: International Journal of Clinical Oncology
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