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Advanced lung cancer inflammation index

Y X Wang, F Fang, Y F Guo, Y M Li, T Y Sun, M Zhang, J Chen, B M Fang
Objective: To study the etiological, clinical, radiological, diagnostic, therapeutic, and prognostic manifestations of exogenous lipoid pneumonia (ELP), and therefore to improve the diagnosis and treatment of this disease. Methods: The clinical data of 12 cases of ELP confirmed by pathology were retrospectively analyzed. Results: The patients consisted of 9 males and 3 females, with an average age of 73.8 years (range, 44 to 100 years). The underlying diseases were variable, including diseases affecting the general condition (multiple organ failure, chronic heart and renal insufficiency, pemphigoid, etc) and conditions with increased risk of aspiration (sequelae of cerebrovascular disease, Alzheimer's disease, advanced stage of nasopharyngeal carcinoma, paralytic ileus, etc)...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
Susanne Blauwhoff-Buskermolen, Jacqueline A E Langius, Annemarie Becker, Henk M W Verheul, Marian A E de van der Schueren
BACKGROUND: Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored. METHODS: Prior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid-upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio-electrical impedance analysis (BIA)...
April 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
Young Hoon Park, Hyeon Gyu Yi, Moon Hee Lee, Chul Soo Kim, Joo Han Lim
BACKGROUND: The Advanced Lung Cancer Inflammation Index (ALI, body mass index × albumin/neutrophil-to-lymphocyte ratio) has been demonstrated to be a prognostic factor of survival in some solid cancers. We retrospectively investigated the usefulness of the ALI to predict chemotherapy response and survival in 212 patients with diffuse large B cell lymphoma (DLBCL) treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy. METHODS: Patients were allocated to a low ALI group (n = 82, 38...
2017: Acta Haematologica
Eun Young Kim, Nambeom Kim, Young Saing Kim, Ja-Young Seo, Inkeun Park, Hee Kyung Ahn, Yu Mi Jeong, Jeong Ho Kim
BACKGROUND: Advanced lung cancer inflammation index (ALI, body mass index [BMI] x serum albumin/neutrophil-lymphocyte ratio [NLR]) has been shown to predict overall survival (OS) in small cell lung cancer (SCLC). CT enables skeletal muscle to be quantified, whereas BMI cannot accurately reflect body composition. The purpose was to evaluate prognostic value of modified ALI (mALI) using CT-determined L3 muscle index (L3MI, muscle area at L3/height2) beyond original ALI. METHODS: L3MIs were calculated using the CT images of 186 consecutive patients with SCLC taken at diagnosis, and mALI was defined as L3MI x serum albumin/NLR...
2016: PloS One
Yang Yu, Hui Guan, Yuanli Dong, Ligang Xing, Xiaolin Li
OBJECTIVE: To summarize the research progress about the dosimetry and biological predictors of radiation-induced esophagitis. METHODS: We performed a systematic literature review addressing radiation esophagitis in the treatment of lung cancer published between January 2009 and May 2015 in the PubMed full-text database index systems. RESULTS: Twenty-eight eligible documents were included in the final analysis. Many clinical factors were related to the risk of radiation esophagitis, such as elder patients, concurrent chemoradiotherapy, and the intense radiotherapy regimen (hyperfractionated radiotherapy or stereotactic body radiotherapy)...
2016: OncoTargets and Therapy
Xiaobo He, Ting Zhou, Yunpeng Yang, Shaodong Hong, Jianhua Zhan, Zhihuang Hu, Wenfeng Fang, Tao Qin, Yuxiang Ma, Yuanyuan Zhao, Zhibin Cheng, Yan Huang, Hongyun Zhao, Guangwei Yang, Li Zhang
UNLABELLED: This report is the first to use the value of the Advanced Lung Cancer Inflammation Index (ALI) to predict the overall survival in patients with small-cell lung cancer. We enrolled 365 patients who were eligible for analysis and found that lower ALI was significantly associated with worse overall survival in small-cell lung cancer patients. The results showed that evaluation using ALI could authenticate the patients with poor prognosis and be a useful prognostic marker in clinical practice...
November 2015: Clinical Lung Cancer
Ji-Feng Feng, Ying Huang, Qi Xun Chen
BACKGROUND: The prognostic value of inflammation indexes in esophageal cancer has not been established. Recent studies have shown that the advanced lung cancer inflammation index (ALI) is a useful predictive factor. The purpose of the current study was to determine whether the ALI is useful for predicting long-term survival in patients with esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: A total of 293 patients who had undergone esophagectomy for ESCC were included...
2014: OncoTargets and Therapy
Mukesh Paudel, Bishal Chhetri, Sahadeb Dhungana, Shamsuddin Amin
SESSION TITLE: COPD Diagnosis and Evaluation Posters ISESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: Chronic obstructive pulmonary disease (COPD) is a disease of lung airways and parenchyma defined by airflow limitation due to inflammatory response to noxious fumes and gases. Systemic inflammation seen in patients with COPD is characterized by systemic oxidative stress that is associated with abnormalities like weight loss...
October 1, 2014: Chest
Antonio L Vigano, Jonathan di Tomasso, Robert D Kilgour, Barbara Trutschnigg, Enriqueta Lucar, José A Morais, Manuel Borod
Cancer cachexia (CC) is a syndrome characterized by wasting of lean body mass and fat, often driven by decreased food intake, hypermetabolism, and inflammation resulting in decreased lifespan and quality of life. Classification of cancer cachexia has improved, but few clinically relevant diagnostic tools exist for its early identification and characterization. The abridged Patient-Generated Subjective Global Assessment (aPG-SGA) is a modification of the original Patient-Generated Subjective Global Assessment, and consists of a four-part questionnaire that scores patients' weight history, food intake, appetite, and performance status...
July 2014: Journal of the Academy of Nutrition and Dietetics
M Yildirim, M Yildiz, E Duman, S Goktas, V Kaya
PURPOSE: Despite all primary prevention and therapeutic efforts around the world, non-small cell lung cancer (NSCLC) continues to be an important public health problem. In the treatment of patients, laboratory parameters can be used for the determination of treatment intensity. These laboratory parameters should be easily accessible, cheap and easy to use. For this purpose, the prognostic importance in NSCLC of serum albumin levels, neutrophil-lymphocyte ratio (NLR) and thrombocyte-lymphocyte ratio (TLR) was investigated in the present study...
July 2013: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Syed H Jafri, Runhua Shi, Glenn Mills
BACKGROUND: Systemic inflammation has been linked with cancer development, cancer cachexia and poor outcome. Advanced lung cancer inflammation index (ALI) was developed to assess degree of systemic inflammation at the time of diagnosis in metastatic non-small cell lung (NSCLC) cancer patients. METHODS: In a single institution retrospective review 173 patients with metastatic NSCLC diagnosed between Jan 1 2000 and June 30 2011 were included. ALI was calculated as (BMI x Alb / NLR) where BMI = body mass index, Alb = serum albumin, NLR (neutrophil lymphocyte ratio, a marker of systemic inflammation)...
2013: BMC Cancer
Ryohei Takahashi, Takashi Sato, Dennis M Klinman, Takeshi Shimosato, Takeshi Kaneko, Yoshiaki Ishigatsubo
Immunosuppressive oligodeoxynucleotides (Sup ODNs) containing repetitive TTAGGG motifs reduce inflammation and, thus, may have an impact on inflammation‑related tumor growth. In this study, we found a significant antiproliferative effect of Sup ODNs on the A549 non‑small cell lung cancer (NSCLC) cell line compared to those treated with control ODNs (p<0.05). Sup-ODN-mediated G1 phase cell cycle arrest was achieved via inhibition of Akt and extracellular signal-regulated kinase 1/2 phosphorylation and the p15INK4b and p27KIP1/retinoblastoma protein pathway...
February 2013: International Journal of Oncology
S Cedrés, D Torrejon, A Martínez, P Martinez, A Navarro, E Zamora, N Mulet-Margalef, E Felip
BACKGROUND: Neutrophil to lymphocyte ratio (NLR), an index of systemic inflammation, has been associated with worse survival for many types of cancer. The aim of this study is to investigate the clinical significance of the blood NLR as a prognostic factor in non-small cell lung cancer (NSCLC) patients. METHODS AND PATIENTS: Stage IV NSCLC patients diagnosed in our institution between April 2004 and March 2009 were retrospectively reviewed. Potential prognostic factors such as histology, gender, performance status, response to chemotherapy and NLR were analyzed...
November 2012: Clinical & Translational Oncology
Eu Chang Hwang, In Sang Hwang, Ho Song Yu, Sun-Ouck Kim, Seung Il Jung, Jun Eul Hwang, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu
OBJECTIVE: Our intent was to investigate the impact of specific parameters-clinical status, performance status (Eastern Cooperative Oncology Group (ECOG)), C-reactive protein, serum albumin, and inflammation (Glasgow Prognostic Score)-on progression-free survival and overall survival in patients given systemic chemotherapy as the first-line treatment of advanced bladder cancer. METHODS: A total of 67 patients treated for advanced bladder cancer in a 7-year period (2004-10) were reviewed...
October 2012: Japanese Journal of Clinical Oncology
Eirini Thanopoulou, George Kotzamanis, Ioannis S Pateras, Nicholaos Ziras, Alexandros Papalambros, Theodoros Mariolis-Sapsakos, Fragiska Sigala, Elizabeth Johnson, Athanassios Kotsinas, Andreas Scorilas, Vassilis G Gorgoulis
Intercellular adhesion molecule-1 (ICAM-1), a cell adhesion molecule with a key role in inflammation and immunosurveillance, has been implicated in carcinogenesis by facilitating instability of the tumor environment. The K469E single nucleotide polymorphism (SNP) (G>A) affects the ICAM-1 mRNA splicing pattern; the alternatively spliced isoform (ICAM-1-S) lacks transmembrane and intracellular domain, which affects the structural and signal transduction properties. Moreover, the expression of ICAM-1 is transcriptionally regulated by p53, and this SNP has been shown to be related with apoptosis...
October 2012: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Karla Sánchez-Lara, Jenny G Turcott, Eva Juárez, Patricia Guevara, Carolina Núñez-Valencia, Luis F Oñate-Ocaña, Diana Flores, Oscar Arrieta
Early identification and treatment of nutritional deficiencies can lead to improved outcomes in the quality of life (QoL) and survival of patients with nonsmall cell lung cancer (NSCLC). Noninvasive techniques are needed to evaluate changes in body composition as part of determining nutritional status. The aim of the study was to evaluate the association of nutritional parameters in health-related quality of life (HRQL) and survival in patients with advanced NSCLC. Chemotherapy-naïve patients with advanced NSCLC with good performance status Eastern Cooperative Oncology Group (ECOG) 0-2 were included prospectively in the study...
2012: Nutrition and Cancer
Xin Shelley Wang, Qiuling Shi, Loretta A Williams, Li Mao, Charles S Cleeland, Ritsuko R Komaki, Gary M Mobley, Zhongxing Liao
Elevations in cancer treatment-induced circulating inflammatory cytokines may be partially responsible for the development of significant symptom burden (e.g., pain, fatigue, distress, disturbed sleep) during concurrent chemoradiation therapy (CXRT). Sixty-two patients undergoing CXRT for locally advanced non-small cell lung cancer (NSCLC) reported symptoms weekly for 15 weeks via the M. D. Anderson Symptom Inventory (MDASI). Serum inflammatory cytokines were assessed weekly during therapy via enzyme-linked immunosorbent assay...
August 2010: Brain, Behavior, and Immunity
A Ricci, S Mariotta, E Bronzetti, P Bruno, L Vismara, C De Dominicis, B Laganà, G Paone, M Mura, P Rogliani, M Mastrangeldo, S Sciacchitano, Cesare Saltini
BACKGROUND AND AIM OF THE WORK: Carbohydrate antigen CA 15-3 is a glycoprotein whose expression, aberrant intracellular localization and changes in glycosylation have been associated with a wide range of cancers. Pulmonary fibrosis represents the final evolution of a chronic inflammation and is defined by the overgrowth of fibroblasts and exaggerated extracellular matrix deposition. The aim of the present study was to evaluate the possible diagnostic role of CA 15-3 in fibrosis in different idiopathic interstitial pneumonias...
July 2009: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Claire L Meek, A Michael Wallace, Lynn M Forrest, Donald C McMillan
BACKGROUND & AIMS: The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer. There is good evidence that nutritional and functional decline in patients with advanced malignant disease is associated with catabolic changes in metabolism. However, defects in anabolism may also contribute towards nutritional decline in patients with cancer. The aim of the present study was to examine the relationship between IGF-1 and IGFBP-3, performance status, mGPS and survival in patients with inoperable NSCLC...
April 2010: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Johanna S Paddison, Jennifer S Temel, Gregory L Fricchione, William F Pirl
OBJECTIVE: Fatigue is currently recognized as an undertreated symptom in cancer. To date the association between fatigue and inflammatory activation has not been examined in patients with advanced cancer. Our exploratory investigation considered whether variations in routinely available hematological parameters relate to the severity of fatigue reports. METHODS: Fatigue, white blood cell differential, and hemoglobin concentration were assessed in 44 Stage IIIb and IV non-small-cell lung cancer (NSCLC) patients...
June 2009: Palliative & Supportive Care
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