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https://www.readbyqxmd.com/read/29924680/immunological-examination-of-peripheral-blood-in-patients-with-colorectal-cancer-compared-to-healthy-controls
#1
Jan Spacek, Michal Vocka, Irena Netikova, Helena Skalova, Pavel Dundr, Bohuslav Konopasek, Eva Zavadova, Petruzelka Lubos
BACKGROUND: The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS: Blood samples were collected from 22 colorectal patients and 25 healthy controls before the start of treatment. All patients were examined by a clinical immunologist to exclude patients with immune disorders and autoimmune diseases. TGF beta 1 and VEGF were measured by ELISA, and anti-tumor cellular immunity cells (CD4, CD8, B cells, NK cells) were measured by flow cytometry...
June 20, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29922080/factors-correlated-with-the-improvement-of-endothelial-dysfunction-during-abatacept-therapy-in-patients-with-rheumatoid-arthritis
#2
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29914893/clinical-relevance-and-suppressive-capacity-of-human-mdsc-subsets
#3
Stephan Lang, Kirsten Bruderek, Cordelia Kaspar, Benedikt Höing, Oliver Kanaan, Nina Dominas, Timon Hussain, Freya Droege, Christian Peter Eyth, Boris Hadaschik, Sven Brandau
PURPOSE: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid cells with immunosuppressive activity. In human disease three major MDSC subpopulations can be defined as monocytic M-MDSC, granulocytic PMN-MDSC and early stage e-MDSC, which lack myeloid lineage markers of the former two subsets. It was the purpose of this study to determine and compare the immunosuppressive capacity and clinical relevance of each of these subsets in patients with solid cancer...
June 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29914666/resveratrol-supplementation-decreases-blood-glucose-without-changing-the-circulating-cd14-cd16-monocytes-and-inflammatory-cytokines-in-patients-with-type-2-diabetes-a-randomized-double-blind-placebo-controlled-study
#4
Hadi Khodabandehloo, ShadiSadat Seyyedebrahimi, Ensieh Nasli Esfahani, Farideh Razi, Reza Meshkani
Chronic low-grade inflammation is the hallmark of type 2 diabetes (T2D). Although in vitro and animal studies have shown that resveratrol exerts anti-inflammatory effects, clinical trials addressing these effects in patients with T2D are limited. Therefore, in the present study, we hypothesized that supplementation of resveratrol might improve inflammatory markers in patients with T2D in a randomized, double-blind, placebo-controlled clinical trial. A total of 45 T2D patients were supplemented with either of 800 mg/d resveratrol or placebo capsules for 8 weeks...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29914578/near-complete-response-to-pembrolizumab-in-microsatellite-stable-metastatic-sebaceous-carcinoma
#5
Evidio Domingo-Musibay, Paari Murugan, Alessio Giubellino, Sandeep Sharma, Daniel Steinberger, Jianling Yuan, Matthew A Hunt, Emil Lou, Jeffrey S Miller
BACKGROUND: Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck. CASE PRESENTATION: A 73 year-old man presented with confusion and was found to have widely disseminated sebaceous carcinoma with metastases to brain, lungs, liver, bowel, lymph nodes, and bone. Following initial treatment of the brain metastases with surgery he received post-operative radiosurgery. He then began systemic immunotherapy with pembrolizumab...
June 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29910806/targeting-the-epidermal-growth-factor-receptor-can-counteract-the-inhibition-of-natural-killer-cell-function-exerted-by-colorectal-tumor-associated-fibroblasts
#6
Delfina Costa, Roberta Venè, Roberto Benelli, Emanuele Romairone, Stefano Scabini, Silvia Catellani, Barbara Rebesco, Luca Mastracci, Federica Grillo, Simona Minghelli, Fabrizio Loiacono, Maria Raffaella Zocchi, Alessandro Poggi
Mesenchymal stromal cells (MSC) present in the tumor microenvironment [usually named tumor-associated fibroblasts (TAF)] can exert immunosuppressive effects on T and natural killer (NK) lymphocytes, favoring tumor immune escape. We have analyzed this mechanism in colorectal carcinoma (CRC) and found that co-culture of NK cells with TAF can prevent the IL-2-mediated NKG2D upregulation. This leads to the impairment of NKG2D-mediated recognition of CRC cells, sparing the NK cell activation through DNAM1 or FcγRIIIA (CD16)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29906454/standardization-of-sampling-and-sample-preparation-for-analysis-of-human-monocyte-subsets-in-peripheral-blood
#7
Ida Marie Rundgren, Øystein Bruserud, Anita Ryningen, Elisabeth Ersvær
INTRODUCTION: Monocytes are important for innate immunity and include the classical (CD14bright CD16negative ), intermediate (CD14bright CD16dim ) and non-classical (CD14dim CD16bright ) monocyte subsets. The quantification of these functionally different subsets in peripheral blood may become useful for diagnosis and follow-up in human diseases. The aim of the present study was to investigate how different pre-analytical parameters influence analysis of monocyte subsets in peripheral blood samples...
June 12, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29905812/defective-cholesterol-metabolism-in-haematopoietic-stem-cells-promotes-monocyte-driven-atherosclerosis-in-rheumatoid-arthritis
#8
Dragana Dragoljevic, Michael J Kraakman, Prabhakara R Nagareddy, Devi Ngo, Waled Shihata, Helene L Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al-Sharea, Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Mark A Febbraio, Jaye Chin-Dusting, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed to explore if increased circulating myeloid cells is associated with impaired atherosclerotic lesion regression or altered progression in RA. Methods and results: Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis in two mouse models of RA...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905559/-clinical-and-immunological-criteria-for-the-adverse-course-of-infectious-mononucleosis-in-children
#9
Ya Kolesnik, T Zharkova, O Rzhevskaya, T Kvaratskheliya, O Sorokina
The article presents the results of our own studies to determine the criteria for the adverse variants of the course of infectious mononucleosis (IM) in children. The study was conducted in the regional children's infectious clinical hospital in Kharkov. 161 children aged three to fifteen years were under observation with diagnosis of infectious moninucleosis. Out of 161 ill children, 140 (86.9%) had moderate severity of disease, and 21 (13.1%) had severe forms. All children were prescribed standard clinical and laboratory-instrumental examinations...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29900190/data-on-impact-of-monocytes-and-glucose-fluctuation-on-plaque-vulnerability-in-patients-with-coronary-artery-disease
#10
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
Data presented in this article are supplementary material to our research article entitled "Impact of CD14++ CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients" [1]. This article contains the data of study population, diagnostic ability of CD14++ CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29900053/quantitative-and-functional-alterations-of-6-sulfo-lacnac-dendritic-cells-in-multiple-myeloma
#11
Baptiste Lamarthée, Frédéric de Vassoigne, Florent Malard, Nicolas Stocker, Inès Boussen, Clémence Médiavilla, Ruoping Tang, Fanny Fava, Laurent Garderet, Zora Marjanovic, Eolia Brissot, Mohamad Mohty, Béatrice Gaugler
Multiple myeloma (MM) results from expansion of abnormal plasma cells in the bone marrow (BM). Previous studies have shown that monocytes play a crucial role in MM pathophysiology. A 6-sulfo LacNAc-expressing population of dendritic cells (Slan-DCs) that overlaps with intermediate and non-classical monocytes in terms of phenotype has been described. Slan-DCs represent a circulating and tissue proinflammatory myeloid population which has been shown to play a role in different cancer contexts, and which exhibits a remarkable plasticity...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899745/alpha-1-antitrypsin-attenuates-m1-microglia-mediated-neuroinflammation-in-retinal-degeneration
#12
Tian Zhou, Zijing Huang, Xiaowei Zhu, Xiaowei Sun, Yan Liu, Bing Cheng, Mei Li, Yizhi Liu, Chang He, Xialin Liu
Neurodegenerative diseases are a set of disorders characterized by progressive neuronal death and are associated with microglia-mediated neuroinflammation. Recently, neuroinflammation is proposed as a promising therapeutic target for many neurodegenerative diseases. Alpha-1 antitrypsin (AAT) is recognized as a novel immunomodulatory agent in autoimmune diseases and transplantation, however, its impact on neuroinflammation and neurodegeneration remains unknown. This study aims to explore the effects of AAT on microglia-mediated neuroinflammation and retinal degeneration in rd1 mouse model...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29898765/ten-weeks-of-high-intensity-interval-walk-training-is-associated-with-reduced-disease-activity-and-improved-innate-immune-function-in-older-adults-with-rheumatoid-arthritis-a-pilot-study
#13
David B Bartlett, Leslie H Willis, Cris A Slentz, Andrew Hoselton, Leslie Kelly, Janet L Huebner, Virginia B Kraus, Jennifer Moss, Michael J Muehlbauer, Guillaume Spielmann, William E Kraus, Janet M Lord, Kim M Huffman
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. We sought to determine whether 10 weeks of a walking-based HIIT program would be associated with health improvements as measured by disease activity and aerobic fitness...
June 14, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29897565/effector-%C3%AE-%C3%AE-t-cells-in-human-renal-fibrosis-and-chronic-kidney-disease
#14
Becker Meng-Po Law, Ray Wilkinson, Xiangju Wang, Katrina Kildey, Mae Lindner, Kenneth Beagley, Helen Healy, Andrew J Kassianos
Background: γδ T cells are effector lymphocytes recognized as key players during chronic inflammatory processes. Mouse studies suggest a pathological role for γδ T cells in models of kidney disease. Here we evaluated γδ T cells in human native kidneys with tubulointerstitial fibrosis, the pathological hallmark of chronic kidney disease. Methods: γδ T cells were extracted from human kidney tissue and enumerated and phenotyped by multicolour flow cytometry...
April 20, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29896414/temporal-gene-expression-profiles-after-focal-cerebral-ischemia-in-mice
#15
Chengjie Zhang, Yanbing Zhu, Song Wang, Zheng Zachory Wei, Michael Qize Jiang, Yongbo Zhang, Yuhualei Pan, Shaoxin Tao, Jimei Li, Ling Wei
A cascade of pathological processes is triggered in the lesion area after ischemic stroke. Unfortunately, our understanding of these complicated molecular events is incomplete. In this investigation, we sought to better understand the detailed molecular and inflammatory events occurring after ischemic stroke. RNA-seq technology was used to identify whole gene expression profiles at days (D1, D3, D7, D14, D21) after focal cerebral ischemia in mice. Enrichment analyses based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms for the differentially expressed genes (DEGs) were then analyzed...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29891204/stereotactic-ablative-radiation-therapy-induces-systemic-differences-in-peripheral-blood-immunophenotype-dependent-on-irradiated-site
#16
Heather M McGee, Megan E Daly, Sohelia Azghadi, Susan L Stewart, Leslie Oesterich, Jeffrey Schlom, Renee Donahue, Jonathan D Schoenfeld, Qian Chen, Shyam Rao, Ruben C Fragoso, Richard K Valicenti, Robert J Canter, Emmanual M Maverakis, William J Murphy, Karen Kelly, Arta M Monjazeb
PURPOSE: Despite the strong interest in combining stereotactic ablative radiation therapy (SAR) with immunotherapy, limited data characterizing the systemic immune response after SAR are available. We hypothesized that the systemic immune response to SAR would differ by irradiated site owing to inherent differences in the microenvironment of various organs. METHODS AND MATERIALS: Patients receiving SAR to any organ underwent prospective blood banking before and 1 to 2 weeks after SAR...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29887861/apvo210-a-bispecific-anti-cd86-il-10-fusion-protein-adaptir%C3%A2-to-induce-antigen-specific-t-regulatory-type-1-cells
#17
Laurence Pellerin, Ping Chen, Silvia Gregori, Gabriela Hernandez-Hoyos, Rosa Bacchetta, Maria Grazia Roncarolo
IL-10 is a potent immunosuppressive cytokine that promotes the differentiation of tolerogenic dendritic cells (DC-10), and the subsequent induction of antigen-specific T regulatory type 1 (Tr1) cells, which suppress immune responses. However, IL-10 acts on multiple cell types and its effects are not solely inhibitory, therefore, limiting its use as immunomodulant. APVO210 is a bispecific fusion protein composed of an anti-CD86 antibody fused with monomeric IL-10 (ADAPTIR™ from Aptevo Therapeutics). APVO210 specifically induces IL-10R signaling in CD86+ antigen-presenting cells, but not in T and B cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29887758/expansion-of-a-population-of-large-monocytes-atypical-monocytes-in-peripheral-blood-of-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-diseases
#18
Jing Yang, Man Qiao, Yanxia Li, Guohua Hu, Chunxia Song, Liping Xue, Hong Bai, Jie Yang, Xi Yang
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is closely associated with airway inflammation including monocytes, lymphocytes, and neutrophils. Monocytes play an essential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). To elucidate the association of circulating monocyte alteration with AECOPD, we analyzed monocyte subpopulation in the peripheral blood of 16 healthy volunteers and 22 AECOPD patients at the stages of admission and remission after clinical therapy...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29885276/age-related-m1-m2-phenotype-changes-in-circulating-monocytes-from-healthy-unhealthy-individuals
#19
Andrea Costantini, Nadia Viola, Antonella Berretta, Roberta Galeazzi, Giulia Matacchione, Jacopo Sabbatinelli, Gianluca Storci, Serena De Matteis, Luca Butini, Maria Rita Rippo, Antonio Domenico Procopio, Daniele Caraceni, Roberto Antonicelli, Fabiola Olivieri, Massimiliano Bonafè
Macrophage polarization is a candidate biomarker of disease-related inflammatory status, but its modulation during aging has not been investigated. To do this, the M1/M2 profile was assessed by CD80/CD163 gating in classical (CD14++ CD16- ), intermediate (CD14++ CD16+ ), and non-classical (CD14low CD16+ ) monocytes from 31 healthy subjects (CTRs) of different ages. Cytofluorimetric analysis showed a significantly different CD80/CD163 distribution in the three subsets, as more than 80% of classical and intermediate monocytes were CD80+ CD163+ , whereas most non-classical monocytes were CD80- CD163- and CD163+ ...
June 8, 2018: Aging
https://www.readbyqxmd.com/read/29875315/intracapillary-immune-complexes-recruit-and-activate-slan-expressing-cd16-monocytes-in-human-lupus-nephritis
#20
Florina Olaru, Thomas Döbel, Anke S Lonsdorf, Stephanie Oehrl, Michael Maas, Alexander H Enk, Marc Schmitz, Elisabeth F Gröne, Hermann-J Gröne, Knut Schäkel
Lupus nephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Among the different types of lupus nephritis, intracapillary immune complex (IC) deposition and accumulation of monocytes are hallmarks of lupus nephritis class III and IV. The relevance of intracapillary ICs in terms of monocyte recruitment and activation, as well as the nature and function of these monocytes are not well understood. For the early focal form of lupus nephritis (class III) we demonstrate a selective accumulation of the proinflammatory population of 6-sulfo LacNAc+ (slan) monocytes (slanMo), which locally expressed TNF-α...
June 7, 2018: JCI Insight
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