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https://www.readbyqxmd.com/read/28574524/purls-consider-melatonin-for-migraine-prevention
#1
Jennie B Jarrett, David Moss
An inexpensive and well-tolerated anticholinergic reduces sweating in those with localized--and generalized--hyperhidrosis.
June 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28497124/parv4-prevalence-phylogeny-immunology-and-coinfection-with-hiv-hbv-and-hcv-in-a-multicentre-african-cohort
#2
Colin P Sharp, William F Gregory, Louise Hattingh, Amna Malik, Emily Adland, Samantha Daniels, Anriette van Zyl, Jonathan M Carlson, Susan Wareing, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Thumbi Ndung'u, Philip J R Goulder, Paul Klenerman, Peter Simmonds, Pieter Jooste, Philippa C Matthews
Background: The seroprevalence of human parvovirus-4 (PARV4) varies considerably by region. In sub-Saharan Africa, seroprevalence is high in the general population, but little is known about the transmission routes or the prevalence of coinfection with blood-borne viruses, HBV, HCV and HIV.  Methods: To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status...
April 7, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28459893/purls-consider-melatonin-for-migraine-prevention
#3
Corey Lyon, Shannon Langner
This affordable, over-the-counter hormone is as effective as amitriptyline, causes fewer adverse effects, and may have a surprising added benefit.
May 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28423831/the-biotop-family-of-upper-level-ontological-resources-for-biomedicine
#4
Stefan Schulz, Martin Boeker, Catalina Martinez-Costa
BioTop is a domain upper level ontology for the life sciences, based on OWL DL, introduced ten years ago. This paper provides an update of the current state of this resource, with a special focus on BioTop's top level, BioTopLite, which currently contains 55 classes, 37 object properties and 247 description logics axioms. A bridging file allows harmonising BioTopLite with the classes of Basic Formal Ontology BFO2. The updated OWL resources are available at http://purl.org/biotop. They build the core of several upper level ontological artefacts including bridging ontologies to other upper level resources...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28375398/purls-when-can-exercise-supplant-surgery-for-degenerative-meniscal-tears
#5
COMPARATIVE STUDY
Jennie B Jarrett, Sandra Sauereisen
Patients with a medial, degenerative meniscal tear and a minimal history of osteoarthritis make good candidates for physical therapy-- and there is an added benefit, too.
April 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28253937/therapeutic-indications-and-other-use-case-driven-updates-in-the-drug-ontology-anti-malarials-anti-hypertensives-opioid-analgesics-and-a-large-term-request
#6
William R Hogan, Josh Hanna, Amanda Hicks, Samira Amirova, Baxter Bramblett, Matthew Diller, Rodel Enderez, Timothy Modzelewski, Mirela Vasconcelos, Chris Delcher
BACKGROUND: The Drug Ontology (DrOn) is an OWL2-based representation of drug products and their ingredients, mechanisms of action, strengths, and dose forms. We originally created DrOn for use cases in comparative effectiveness research, primarily to identify historically complete sets of United States National Drug Codes (NDCs) that represent packaged drug products, by the ingredient(s), mechanism(s) of action, and so on contained in those products. Although we had designed DrOn from the outset to carefully distinguish those entities that have a therapeutic indication from those entities that have a molecular mechanism of action, we had not previously represented in DrOn any particular therapeutic indication...
March 3, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28249056/purls-cold-turkey-works-best-for-smoking-cessation
#7
REVIEW
Dustin K Smith, Deborah E Miller, Anne Mounsey
Counsel patients who want to quit smoking that doing so abruptly leads to higher cessation rates than does quitting gradually.
March 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28222458/purls-steroids-during-late-preterm-labor-better-later-than-never
#8
REVIEW
Corey Lyon, Jennifer K Bello
Steroids--even when administered in the last leg of the late preterm period--still reduce the likelihood of respiratory complications in newborns.
February 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28188318/purls-need-an-add-on-to-metformin-consider-this
#9
REVIEW
David Wyncott, Corey Lyon, Anne Mounsey
Sulfonylureas have been the preferred add-on therapy to metformin for T2DM, but a study finds that DPP-4s have lower risks of death, CV events, and hypoglycemia.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28178937/spang-a-sparql-client-supporting-generation-and-reuse-of-queries-for-distributed-rdf-databases
#10
Hirokazu Chiba, Ikuo Uchiyama
BACKGROUND: Toward improved interoperability of distributed biological databases, an increasing number of datasets have been published in the standardized Resource Description Framework (RDF). Although the powerful SPARQL Protocol and RDF Query Language (SPARQL) provides a basis for exploiting RDF databases, writing SPARQL code is burdensome for users including bioinformaticians. Thus, an easy-to-use interface is necessary. RESULTS: We developed SPANG, a SPARQL client that has unique features for querying RDF datasets...
February 8, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28149974/purls-a-more-palatable-alternative-to-oral-rehydration-therapy-for-kids
#11
REVIEW
Carin E Reust, James J Stevermer, Jennie B Jarrett
Parents no longer need to struggle to get their kids to drink electrolyte solutions during episodes of mild gastroenteritis; apple juice works just as well.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28087870/purls-deliver-or-wait-with-late-preterm-membrane-rupture
#12
Keri Bergeson, Shailendra Prasad
While ACOG recommends delivery for all women with ruptured membranes after 34 weeks' gestation, a new study finds expectant management may be the way to go.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27991802/a-computational-model-of-self-efficacy-s-various-effects-on-performance-moving-the-debate-forward
#13
Jeffrey B Vancouver, Justin D Purl
Self-efficacy, which is one's belief in one's capacity, has been found to both positively and negatively influence effort and performance. The reasons for these different effects have been a major topic of debate among social-cognitive and perceptual control theorists. In particular, the findings of various self-efficacy effects has been motivated by a perceptual control theory view of self-regulation that social-cognitive theorists' question. To provide more clarity to the theoretical arguments, a computational model of the multiple processes presumed to create the positive, negative, and null effects for self-efficacy is presented...
April 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/27899649/protein-ontology-pro-enhancing-and-scaling-up-the-representation-of-protein-entities
#14
Darren A Natale, Cecilia N Arighi, Judith A Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J Drabkin, William D Duncan, Hongzhan Huang, Jia Ren, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Qinghua Wang, Jian Zhang, Abdelrahman El-Sayed, Cathy H Wu
The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification reference...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27846332/purls-monitoring-home-bp-readings-just-got-easier
#15
Jennie B Jarrett, Linda Hogan, Corey Lyon, Kate Rowland
This novel method of identifying patients with uncontrolled hypertension correlates well with ambulatory BP monitoring.
October 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27818108/gating-role-of-his-72-in-tmpurl-enzyme-uncovered-by-structural-analyses-and-molecular-dynamics-simulations
#16
Biplab Ghosh, Venuka Durani Goyal
Histidine is ubiquitous in enzyme active sites but its role is often difficult to ascribe due to ambiguity of protonation state and complex electrostatic and dynamic effects involved. In this study the role of His 72 in TmPurL, a glutamine amidotransferase (GAT) enzyme, is investigated. TmPurL is a large 66kDa enzyme that works as part of an even larger (>100kDa) multi-protein complex. This enzyme complex performs an essential step in the purine biosynthesis pathway by abstracting ammonia from a glutamine molecule and channeling it 30Å away into the active site of TmPurL, incorporating it into a purine biosynthesis intermediate...
October 25, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27672689/purls-yeast-infection-in-pregnancy-think-twice-about-fluconazole
#17
COMPARATIVE STUDY
Amir Barzin, Anne Mounsey
This study's findings regarding the risk of miscarriage may mean it's time to forego fluconazole in favor of topical azoles as first-line treatment.
September 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27664130/the-environment-ontology-in-2016-bridging-domains-with-increased-scope-semantic-density-and-interoperation
#18
Pier Luigi Buttigieg, Evangelos Pafilis, Suzanna E Lewis, Mark P Schildhauer, Ramona L Walls, Christopher J Mungall
BACKGROUND: The Environment Ontology (ENVO; http://www.environmentontology.org/ ), first described in 2013, is a resource and research target for the semantically controlled description of environmental entities. The ontology's initial aim was the representation of the biomes, environmental features, and environmental materials pertinent to genomic and microbiome-related investigations. However, the need for environmental semantics is common to a multitude of fields, and ENVO's use has steadily grown since its initial description...
September 23, 2016: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/27660840/purls-on-demand-pill-protocol-protects-against-hiv
#19
Kathryn Justesen, Shailendra Prasad
Finally, there's an effective prevention strategy--other than condoms--that can be used, as needed, by patients at high risk for HIV infection.
August 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27565102/purls-light-therapy-for-nonseasonal-major-depressive-disorder
#20
RANDOMIZED CONTROLLED TRIAL
Kehinde Eniola, Angela Bacigalupo, Anne Mounsey
While bright light therapy already has a place in the treatment of seasonal affective disorder, a recent trial spotlights its utility beyond the winter months.
July 2016: Journal of Family Practice
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