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https://www.readbyqxmd.com/read/29202146/purls-does-azithromycin-have-a-role-in-cesarean-sections
#1
Gregory Castelli, Allison Flaherty, Jennie B Jarrett
A 26-year-old G1P0 at 40w1d presents in spontaneous labor and is dilated to 4 cm. The patient reached complete cervical dilation after artificial rupture of membranes and oxytocin augmentation. After 4 hours of pushing, there has been minimal descent of the fetal vertex beyond +1 station with significant caput succedaneum. Her physician decides to proceed with cesarean delivery. What antibiotics should be administered prior to incision to reduce postoperative infection?
December 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29099511/purls-the-benefits-and-limits-of-ppis-with-warfarin-regimens
#2
Alicia Ludden-Schlatter, James J Stevermer
Patients on warfarin plus antiplatelet/NSAID regimens are likely to benefit from the gastroprotective effect of PPIs. For patients taking warfarin alone, it's a different story.
November 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28991939/purls-when-to-cap-off-treatment-for-pneumonia
#3
Gregory Castelli, Jennie B Jarrett
Prescribe 5 days of antibiotic treatment for inpatients with community-acquired pneumonia because it produces the same clinical success rates as longer treatment regimens, but is associated with fewer negative patient outcomes.
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28863203/purls-ssris-for-depression-heart-failure-patients-not-so-fast
#4
Jason Ricco, Janice Benson, Shailendra Prasad
This study should put to rest the practice of starting SSRIs in depressed patients with heart failure in an attempt to affect CVD outcomes.
September 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28783771/purls-direct-oral-anticoagulants-or-warfarin-for-a-fib
#5
Corey Lyon, Alex Reed, Shailendra Prasad
A recent study evaluated the effectiveness of 3 direct oral anticoagulants and warfarin in patients with atrial fibrillation. So which agents came out on top?
August 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28700760/purls-which-combined-oc-to-prescribe-with-cv-safety-in-mind
#6
Yee Lam, Catherine Coe, Anne Mounsey
With various formulations available, which combined OC should you recommend to minimize not only the risk of PE, but also the risk of stroke and MI?
July 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28574524/purls-oral-agent-offers-relief-from-generalized-hyperhidrosis
#7
Jennie B Jarrett, David Moss
An inexpensive and well-tolerated anticholinergic reduces sweating in those with localized--and generalized--hyperhidrosis.
June 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28497124/parv4-prevalence-phylogeny-immunology-and-coinfection-with-hiv-hbv-and-hcv-in-a-multicentre-african-cohort
#8
Colin P Sharp, William F Gregory, Louise Hattingh, Amna Malik, Emily Adland, Samantha Daniels, Anriette van Zyl, Jonathan M Carlson, Susan Wareing, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Thumbi Ndung'u, Philip J R Goulder, Paul Klenerman, Peter Simmonds, Pieter Jooste, Philippa C Matthews
Background: The seroprevalence of human parvovirus-4 (PARV4) varies considerably by region. In sub-Saharan Africa, seroprevalence is high in the general population, but little is known about the transmission routes or the prevalence of coinfection with blood-borne viruses, HBV, HCV and HIV.  Methods: To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status...
April 7, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28459893/purls-consider-melatonin-for-migraine-prevention
#9
Corey Lyon, Shannon Langner
This affordable, over-the-counter hormone is as effective as amitriptyline, causes fewer adverse effects, and may have a surprising added benefit.
May 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28423831/the-biotop-family-of-upper-level-ontological-resources-for-biomedicine
#10
Stefan Schulz, Martin Boeker, Catalina Martinez-Costa
BioTop is a domain upper level ontology for the life sciences, based on OWL DL, introduced ten years ago. This paper provides an update of the current state of this resource, with a special focus on BioTop's top level, BioTopLite, which currently contains 55 classes, 37 object properties and 247 description logics axioms. A bridging file allows harmonising BioTopLite with the classes of Basic Formal Ontology BFO2. The updated OWL resources are available at http://purl.org/biotop. They build the core of several upper level ontological artefacts including bridging ontologies to other upper level resources...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28375398/purls-when-can-exercise-supplant-surgery-for-degenerative-meniscal-tears
#11
COMPARATIVE STUDY
Jennie B Jarrett, Sandra Sauereisen
Patients with a medial, degenerative meniscal tear and a minimal history of osteoarthritis make good candidates for physical therapy-- and there is an added benefit, too.
April 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28253937/therapeutic-indications-and-other-use-case-driven-updates-in-the-drug-ontology-anti-malarials-anti-hypertensives-opioid-analgesics-and-a-large-term-request
#12
William R Hogan, Josh Hanna, Amanda Hicks, Samira Amirova, Baxter Bramblett, Matthew Diller, Rodel Enderez, Timothy Modzelewski, Mirela Vasconcelos, Chris Delcher
BACKGROUND: The Drug Ontology (DrOn) is an OWL2-based representation of drug products and their ingredients, mechanisms of action, strengths, and dose forms. We originally created DrOn for use cases in comparative effectiveness research, primarily to identify historically complete sets of United States National Drug Codes (NDCs) that represent packaged drug products, by the ingredient(s), mechanism(s) of action, and so on contained in those products. Although we had designed DrOn from the outset to carefully distinguish those entities that have a therapeutic indication from those entities that have a molecular mechanism of action, we had not previously represented in DrOn any particular therapeutic indication...
March 3, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28249056/purls-cold-turkey-works-best-for-smoking-cessation
#13
REVIEW
Dustin K Smith, Deborah E Miller, Anne Mounsey
Counsel patients who want to quit smoking that doing so abruptly leads to higher cessation rates than does quitting gradually.
March 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28222458/purls-steroids-during-late-preterm-labor-better-later-than-never
#14
REVIEW
Corey Lyon, Jennifer K Bello
Steroids--even when administered in the last leg of the late preterm period--still reduce the likelihood of respiratory complications in newborns.
February 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28188318/purls-need-an-add-on-to-metformin-consider-this
#15
REVIEW
David Wyncott, Corey Lyon, Anne Mounsey
Sulfonylureas have been the preferred add-on therapy to metformin for T2DM, but a study finds that DPP-4s have lower risks of death, CV events, and hypoglycemia.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28178937/spang-a-sparql-client-supporting-generation-and-reuse-of-queries-for-distributed-rdf-databases
#16
Hirokazu Chiba, Ikuo Uchiyama
BACKGROUND: Toward improved interoperability of distributed biological databases, an increasing number of datasets have been published in the standardized Resource Description Framework (RDF). Although the powerful SPARQL Protocol and RDF Query Language (SPARQL) provides a basis for exploiting RDF databases, writing SPARQL code is burdensome for users including bioinformaticians. Thus, an easy-to-use interface is necessary. RESULTS: We developed SPANG, a SPARQL client that has unique features for querying RDF datasets...
February 8, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28149974/purls-a-more-palatable-alternative-to-oral-rehydration-therapy-for-kids
#17
REVIEW
Carin E Reust, James J Stevermer, Jennie B Jarrett
Parents no longer need to struggle to get their kids to drink electrolyte solutions during episodes of mild gastroenteritis; apple juice works just as well.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28087870/purls-deliver-or-wait-with-late-preterm-membrane-rupture
#18
Keri Bergeson, Shailendra Prasad
While ACOG recommends delivery for all women with ruptured membranes after 34 weeks' gestation, a new study finds expectant management may be the way to go.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27991802/a-computational-model-of-self-efficacy-s-various-effects-on-performance-moving-the-debate-forward
#19
Jeffrey B Vancouver, Justin D Purl
Self-efficacy, which is one's belief in one's capacity, has been found to both positively and negatively influence effort and performance. The reasons for these different effects have been a major topic of debate among social-cognitive and perceptual control theorists. In particular, the findings of various self-efficacy effects has been motivated by a perceptual control theory view of self-regulation that social-cognitive theorists' question. To provide more clarity to the theoretical arguments, a computational model of the multiple processes presumed to create the positive, negative, and null effects for self-efficacy is presented...
April 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/27899649/protein-ontology-pro-enhancing-and-scaling-up-the-representation-of-protein-entities
#20
Darren A Natale, Cecilia N Arighi, Judith A Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J Drabkin, William D Duncan, Hongzhan Huang, Jia Ren, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Qinghua Wang, Jian Zhang, Abdelrahman El-Sayed, Cathy H Wu
The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification reference...
January 4, 2017: Nucleic Acids Research
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