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Hiv cardiovascular disease

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https://www.readbyqxmd.com/read/28716008/does-infection-with-human-immunodeficiency-virus-have-any-impact-on-the-cardiovascular-outcomes-following-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#1
Pravesh Kumar Bundhun, Manish Pursun, Wei-Qiang Huang
BACKGROUND: A direct link between human immunodeficiency virus (HIV)-infected patients and the risk of cardiovascular diseases (CVD) has been shown in recent scientific research. However, this issue is controversial since other previous reports showed no apparent impact of HIV or its anti-retroviral drugs on the cardiovascular system. We aimed to systematically compare the postinterventional adverse cardiovascular outcomes which were observed in patients with and without HIV infection during a mean follow up period ranging from 1 year to 3 years...
July 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28715065/hypertension-dyslipidemia-and-cardiovascular-risk-in-hiv-infected-adults-in-poland
#2
Magdalena Rogalska-Płońska, Paweł Rogalski, Magdalena Leszczyszyn-Pynka, Justyna Stempkowska, Piotr Kocbach, Aldona Kowalczuk-Kot, Małgorzata Janczarek, Anna Grzeszczuk
BACKGROUND: Prevalence of cardiovascular diseases (CVD) in HIV infected patients increases with aging and duration of the disease. Hypertension (HA), high cholesterol level obesity, diabetes, tobacco exposure and use of alcohol are among the traditional risk factors that contribute to CVD. AIM: was to determinate the incidence of HA, lipid disturbances and CVD risk in dependence on clinical, viral and biochemical factors. METHODS: Four hundred and seventeen HIV infected Caucasian adult patients from the four clinical centers in Poland were enrolled and analyzed on the basis of available medical data from the years 2013-2015...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28713869/association-of-anisocytosis-with-markers-of-immune-activation-and-exhaustion-in-treated-hiv
#3
Sadeer G Al-Kindi, David A Zidar, Grace A McComsey, Chris T Longenecker
BACKGROUND: Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell distribution width (RDW), is independently associated with prevalent CVD in people living with HIV (PLHIV). In this study, we sought to identify immune correlates of RDW in PLHIV receiving antiretroviral therapy. METHODS: We performed a cross-sectional and longitudinal analysis of 147 virally-suppressed PLHIV, who had LDL < 130 mg/dL and evidence of heightened inflammation, in a randomized trial of statin therapy...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28707319/tenofovir-disoproxil-fumarate-significantly-decreases-serum-lipoprotein-levels-compared-with-entecavir-nucleos-t-ide-analogue-therapy-in-chronic-hepatitis-b-carriers
#4
A A Shaheen, M AlMattooq, S Yazdanfar, K W Burak, M G Swain, S E Congly, M A Borman, S S Lee, R P Myers, C S Coffin
BACKGROUND: Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are first-line treatments for chronic hepatitis B (CHB). Studies suggest lipid lowering effect of TDF in human immunodeficiency virus positive (HIV+) individuals, but the effect on lipids and cardiovascular disease (CVD) risk in CHB is unknown. AIM: To compare TDF vs ETV effects on lipid levels in CHB. METHODS: In this retrospective cohort study, data on serum lipids and CVD risk factors at baseline and ~1 year on TDF or ETV were collected from CHB carriers...
July 13, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28694350/prevalence-of-metabolic-syndrome-discrete-or-comorbid-diabetes-and-hypertension-in-sub-saharan-africa-among-people-living-with-hiv-versus-hiv-negative-populations-a-systematic-review-and-meta-analysis-protocol
#5
Olamide O Todowede, Benn Sartorius
INTRODUCTION: Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, discrete or comorbid diabetes and hypertension in PLHIV compared with HIV-negative population has not been quantified. This review and meta-analysis aims to compare and analyse the prevalence of these trio conditions between HIV-negative and HIV-positive populations in sub-Saharan Africa (SSA)...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28692532/cardiovascular-outcomes-among-hiv-infected-veterans-receiving-atazanavir-a-us-national-historical-cohort-study
#6
Joanne Lafleur, Adam P Bress, Lisa Rosenblatt, Jacob Crook, Paul E Sax, Joel Myers, Corey Ritchings
OBJECTIVE: Patients with HIV infection have an increased risk of cardiovascular disease compared with uninfected individuals. Antiretroviral therapy with atazanavir delays progression of atherosclerosis markers; whether this reduces cardiovascular disease event risk compared with other antiretroviral regimens is currently unknown. DESIGN: Population-based, non-interventional, historical cohort study conducted from July 1, 2003, through December 31, 2015. SETTING: Veterans Health Administration (VHA) hospitals and clinics throughout the United States...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28688235/hiv-associated-cardiovascular-disease-role-of-connexin-43
#7
Lisa Prevedel, Camilla Morocho, Michael V L Bennett, Eliseo A Eugenin
Chronic HIV infection due to effective antiretroviral treatment has resulted in a broad range of clinical complications, including accelerated heart disease. Individuals with HIV infection have a 1.5 to 2 times higher incidence of cardiovascular diseases than their uninfected counterparts; however, the underlying mechanisms are poorly understood. To explore the link between HIV infection and cardiovascular diseases, we used postmortem human heart tissues obtained from HIV-infected and control uninfected individuals to examine connexin 43 (Cx43) expression and distribution and HIV-associated inflammation...
July 5, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28686287/food-intake-and-darunavir-plasma-concentrations-in-people-living-with-hiv-in-an-outpatient-setting
#8
A Daskapan, D Dijkema, D A de Weerd, W F W Bierman, J G W Kosterink, T S van der Werf, J W C Alffenaar, Y Stienstra
Patients receiving darunavir are advised to take it concomitantly with food. The objectives of this study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic. In this cross-sectional study participants treated with darunavir/ritonavir once daily were subjected to a food recall-questionnaire concerning their last concomitant food intake with darunavir. Darunavir trough concentrations were calculated. For the 60 participants the median food intake was 507 (0 - 2707) kcal; protein intake, 20 (0 - 221)g; carbohydrates, 62 (0 - 267)g; fat intake: 14 (0 - 143)g; and dietary fiber: 4 (0 - 30)g...
July 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28679283/integrating-cardiovascular-diseases-hypertension-and-diabetes-with-hiv-services-a-systematic-review
#9
Victoria Haldane, Helena Legido-Quigley, Fiona Leh Hoon Chuah, Louise Sigfrid, Georgina Murphy, Suan Ee Ong, Francisco Cervero-Liceras, Nicola Watt, Dina Balabanova, Sue Hogarth, Will Maimaris, Kent Buse, Martin McKee, Peter Piot, Pablo Perel
Non-communicable diseases (NCDs), including cardiovascular diseases (CVD), hypertension and diabetes together with HIV infection are among the major public health concerns worldwide. Health services for HIV and NCDs require health systems that provide for people's chronic care needs, which present an opportunity to coordinate efforts and create synergies between programs to benefit people living with HIV and/or AIDS and NCDs. This review included studies that reported service integration for HIV and/or AIDS with coronary heart diseases, chronic CVD, cerebrovascular diseases (stroke), hypertension or diabetes...
July 5, 2017: AIDS Care
https://www.readbyqxmd.com/read/28674087/cardiovascular-disease-imaging-in-hiv-novel-phenotypes-and-new-targets-for-risk-reduction
#10
EDITORIAL
Steven Grinspoon, Udo Hoffmann
No abstract text is available yet for this article.
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28674084/utility-of-2013-american-college-of-cardiology-american-heart-association-cholesterol-guidelines-in-hiv-infected-adults-with-carotid-atherosclerosis
#11
Binh An P Phan, Bernard Weigel, Yifei Ma, Rebecca Scherzer, Danny Li, Sophia Hur, S C Kalapus, Steven Deeks, Priscilla Hsue
BACKGROUND: Although HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins. We compared the 2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III recommendations in HIV-infected adults and evaluated associations with carotid artery intima-media thickness and plaque. METHODS AND RESULTS: Carotid artery intima-media thickness was measured at baseline and 3 years later in 352 HIV-infected adults without clinical atherosclerotic CVD and not on statins...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28665888/a-health-profile-associated-with-excessive-alcohol-use-independently-predicts-aortic-stiffness-over-10-years-in-black-south-africans
#12
Melissa Maritz, Carla M T Fourie, Johannes M van Rooyen, Iolanthe M Kruger, Aletta E Schutte
OBJECTIVE: Black populations exhibit higher arterial stiffness than whites and suffer a disproportionate burden of cardiovascular disease. It is therefore important to identify modifiable health behaviours predicting large artery stiffness in blacks. We examined whether traditional cardiovascular risk factors and health behaviours of black South Africans predict large artery stiffness 10 years later. METHODS: We included 650 HIV-free participants (32.8% men) and collected data in rural and urban areas of the North West Province in 2005 and 2015...
June 29, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28664622/subclinical-atherosclerosis-in-low-framingham-risk-hiv-patients
#13
Rafael León, Sergio Reus, Nicolás López, Irene Portilla, José Sánchez-Payá, Livia Giner, Vicente Boix, Esperanza Merino, Diego Torrús, Óscar Moreno, Joaquín Portilla
BACKGROUND: Pathogenesis of atherosclerosis is complex and differences between HIV-infected patients and general population cannot be completely explained by the higher prevalence of traditional cardiovascular risk factors. We aimed to analyse the association between inflammation and subclinical atherosclerosis in HIV patients with low Framingham risk score. MATERIALS AND METHODS: Case-control study. SETTING: outpatient Infectious Diseases clinic in a university hospital...
June 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28662159/pre-clinical-carotid-atherosclerosis-and-scd163-among-virally-suppressed-hiv-patients-in-botswana-compared-with-uninfected-controls
#14
Mosepele Mosepele, Linda C Hemphill, Walter Moloi, Sikhulile Moyo, Isaac Nkele, Joseph Makhema, Kara Bennett, Virginia A Triant, Shahin Lockman
OBJECTIVES: Human immune deficiency virus (HIV) is associated with increased cardiovascular disease (CVD) risk, yet the relationship between HIV and carotid atherosclerosis / monocyte activation among virally suppressed HIV-infected patients in sub-Saharan Africa is not well understood. METHODS: We measured traditional CVD risk factors, bilateral distal common carotid intima media thickness (cIMT), presence of carotid plaque and plasma sCD163 levels among virally suppressed HIV-infected adults and HIV-uninfected controls, in a cross-sectional study in Gaborone, Botswana...
2017: PloS One
https://www.readbyqxmd.com/read/28661459/macrophages-and-phospholipases-at-the-intersection-between-inflammation-and-the-pathogenesis-of-hiv-1-infection
#15
REVIEW
Francesca Spadaro, Serena Cecchetti, Laura Fantuzzi
Persistent low grade immune activation and chronic inflammation are nowadays considered main driving forces of the progressive immunologic failure in effective antiretroviral therapy treated HIV-1 infected individuals. Among the factors contributing to this phenomenon, microbial translocation has emerged as a key driver of persistent immune activation. Indeed, the rapid depletion of gastrointestinal CD4⁺ T lymphocytes occurring during the early phases of infection leads to a deterioration of the gut epithelium followed by the translocation of microbial products into the systemic circulation and the subsequent activation of innate immunity...
June 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28645263/microbiota-dependent-metabolite-and-cardiovascular-disease-marker-trimethylamine-n-oxide-tmao-is-associated-with-monocyte-activation-but-not-platelet-function-in-untreated-hiv-infection
#16
Judith M Haissman, Anna K Haugaard, Sisse R Ostrowski, Rolf K Berge, Johannes R Hov, Marius Trøseid, Susanne D Nielsen
BACKGROUND: HIV infection is associated with increased risk of cardiovascular disease beyond that explained by traditional risk factors. Altered gut microbiota, microbial translocation, and immune activation have been proposed as potential triggers. The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) predicts myocardial infarction (MI) in the general population and has recently been shown to induce platelet hyperreactivity. In the present study, we investigated if TMAO was associated with platelet function, microbial translocation, and immune activation in both untreated and combination anti-retroviral therapy (cART) HIV infection...
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28641798/hiv-1-associated-atherosclerosis-unraveling-the-missing-link
#17
REVIEW
Alison Kearns, Jennifer Gordon, Tricia H Burdo, Xuebin Qin
Cardiovascular disease, including atherosclerosis and atherosclerosis-associated complications, is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV) patients in the post-antiretroviral therapy era. HIV alone accelerates atherosclerosis. Antiretroviral therapy; HIV-associated comorbidities, such as dyslipidemia, drug abuse, and opportunistic infections; and lifestyle are risk factors for HIV-associated atherosclerosis. However, our current understanding of HIV-associated atherogenesis is very limited and has largely been obtained from clinical observation...
June 27, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28641056/the-odd-couple-using-biomedical-and-intersectional-approaches-to-address-health-inequities
#18
Olena Hankivsky, Lesley Doyal, Gillian Einstein, Ursula Kelly, Janet Shim, Lynn Weber, Robin Repta
BACKGROUND: Better understanding and addressing health inequities is a growing global priority. OBJECTIVE: In this paper, we contribute to the literature examining complex relationships between biological and social dimensions in the field of health inequalities. Specifically, we explore the potential of intersectionality to advance current approaches to socio-biological entwinements. DESIGN: We provide a brief overview of current approaches to combining both biological and social factors in a single study, and then investigate the contributions of an intersectional framework to such work...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28622754/prevalence-of-non-infectious-comorbidities-in-the-hiv-positive-population-in-belgium-a-multicenter-retrospective-study
#19
Jessie Gunter, Steven Callens, Stephane De Wit, Jean-Christophe Goffard, Michel Moutschen, Gilles Darcis, Christelle Meuris, Charlotte van den Bulcke, Karine Fombellida, Marc Del Forge, Homie Razavi, Chloe Wyndham-Thomas
OBJECTIVES: In Belgium, eleven AIDS Reference Centers (ARCs) and seven AIDS Reference Laboratories diagnose and treat HIV-positive individuals and track patients under care. As AIDS-related deaths are avoided and the HIV-positive population ages, non-infectious comorbidities (NICMs), such as cardiovascular disease, renal disease and certain cancers, play a larger role in the quality and length of patients' lives. This study aims to characterize the HIV-positive population in Belgium in terms of the prevalence of key NICMs...
June 16, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28614245/wellens-syndrome-in-hiv-infected-patients-two-case-reports
#20
Bowei Tan, Carlos Morales-Mangual, Dan Zhao, Abdullah Khan, Hal Chadow
BACKGROUND: Wellens syndrome is a pattern of electrocardiographic (ECG) changes in the context of unstable angina characterized with deep inverted T-waves or biphasic T-waves in the precordial leads. These specific ECG changes are highly suggestive of stenosis in the left anterior descending artery (LAD), which can result in acute myocardial infarction, left ventricular dysfunction, or death. Human immunodeficiency virus (HIV) infection is known as an independent risk factor for the cardiovascular disease...
June 2017: Medicine (Baltimore)
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