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https://www.readbyqxmd.com/read/28926510/restoring-vaginal-function-in-postmenopausal-women-with-genitourinary-syndrome-of-menopause
#1
Risa Kagan, Eliza Rivera
Menopause practitioners are often asked to help postmenopausal women restore vaginal health and function. A common scenario is the postmenopausal woman who has been without a sexual partner for many years and is now about to resume or has already unsuccessfully attempted penetrative sexual activity. This Practice Pearl addresses the pathophysiology and effect of atrophic genital changes and offers advice on how vaginal health and comfortable sexual activity can be restored.
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28923525/morphological-and-functional-characterization-of-the-hemocytes-from-the-pearl-oyster-pteria-hirundo-and-their-immune-responses-against-vibrio-infections
#2
Graziela Cleuza Vieira, Patrícia Mirella da Silva, Margherita Anna Barracco, Augusto Ferrari Hering, Marcos Caivano Pedroso de Albuquerque, Jaqueline da Rosa Coelho, Éder Carlos Schmidt, Zenilda Laurita Bouzon, Rafael Diego Rosa, Luciane Maria Perazzolo
Hemocyte populations of the pearl oyster Pteria hirundo were characterized at morphological, ultrastructural and functional levels. Three main hemocyte populations were identified: hyalinocytes, granulocytes and blast-like cells. Hyalinocytes were the most abundant population (88.2%) characterized by the presence of few or no granules in the cytoplasm and composed by two subpopulations, large and small hyalinocytes. Comparatively, granulocytes represented 2.2% of the hemocyte population and were characterized by the presence of numerous large electron-lucid granules in the cytoplasm...
September 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28922347/pearl-millet-genome-sequence-provides-a-resource-to-improve-agronomic-traits-in-arid-environments
#3
Rajeev K Varshney, Chengcheng Shi, Mahendar Thudi, Cedric Mariac, Jason Wallace, Peng Qi, He Zhang, Yusheng Zhao, Xiyin Wang, Abhishek Rathore, Rakesh K Srivastava, Annapurna Chitikineni, Guangyi Fan, Prasad Bajaj, Somashekhar Punnuri, S K Gupta, Hao Wang, Yong Jiang, Marie Couderc, Mohan A V S K Katta, Dev R Paudel, K D Mungra, Wenbin Chen, Karen R Harris-Shultz, Vanika Garg, Neetin Desai, Dadakhalandar Doddamani, Ndjido Ardo Kane, Joann A Conner, Arindam Ghatak, Palak Chaturvedi, Sabarinath Subramaniam, Om Parkash Yadav, Cécile Berthouly-Salazar, Falalou Hamidou, Jianping Wang, Xinming Liang, Jérémy Clotault, Hari D Upadhyaya, Philippe Cubry, Bénédicte Rhoné, Mame Codou Gueye, Ramanjulu Sunkar, Christian Dupuy, Francesca Sparvoli, Shifeng Cheng, R S Mahala, Bharat Singh, Rattan S Yadav, Eric Lyons, Swapan K Datta, C Tom Hash, Katrien M Devos, Edward Buckler, Jeffrey L Bennetzen, Andrew H Paterson, Peggy Ozias-Akins, Stefania Grando, Jun Wang, Trilochan Mohapatra, Wolfram Weckwerth, Jochen C Reif, Xin Liu, Yves Vigouroux, Xun Xu
Pearl millet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million farmers in arid and semi-arid regions of sub-Saharan Africa, India and South Asia. We report the ∼1.79 Gb draft whole genome sequence of reference genotype Tift 23D2B1-P1-P5, which contains an estimated 38,579 genes. We highlight the substantial enrichment for wax biosynthesis genes, which may contribute to heat and drought tolerance in this crop. We resequenced and analyzed 994 pearl millet lines, enabling insights into population structure, genetic diversity and domestication...
September 18, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28919652/causal-inference-with-a-graphical-hierarchy-of-interventions
#4
Ilya Shpitser, Eric Tchetgen Tchetgen
Identifying causal parameters from observational data is fraught with subtleties due to the issues of selection bias and confounding. In addition, more complex questions of interest, such as effects of treatment on the treated and mediated effects may not always be identified even in data where treatment assignment is known and under investigator control, or may be identified under one causal model but not another. Increasingly complex effects of interest, coupled with a diversity of causal models in use resulted in a fragmented view of identification...
December 2016: Annals of Statistics
https://www.readbyqxmd.com/read/28918902/mtor-controls-mitochondrial-dynamics-and-cell-survival-via-mtfp1
#5
Masahiro Morita, Julien Prudent, Kaustuv Basu, Vanessa Goyon, Sakie Katsumura, Laura Hulea, Dana Pearl, Nadeem Siddiqui, Stefan Strack, Shawn McGuirk, Julie St-Pierre, Ola Larsson, Ivan Topisirovic, Hojatollah Vali, Heidi M McBride, John J Bergeron, Nahum Sonenberg
The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well understood. Here, we demonstrate that the nutrient-sensing mechanistic/mammalian target of rapamycin complex 1 (mTORC1) stimulates translation of mitochondrial fission process 1 (MTFP1) to control mitochondrial fission and apoptosis. Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1)...
September 13, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28918252/a-pdgf-vegf-homologue-provides-new-insights-into-the-nucleus-grafting-operation-and-immune-response-in-the-pearl-oyster-pinctada-fucata
#6
Xian-De Huang, Hua Zhang, Mao-Xian He
The platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF, PVF) family of proteins have been implicated in a wide range of biological functions in vertebrates, including cell proliferation, cell differentiation, cell migration, neural development and especially angiogenesis/vasculogenesis. In this study, a PVF gene, belonging to the PDGF/VEGF family, was cloned and characterized from Pinctada fucata. It contained an ORF of 1110bp encoding a putative protein of 369 amino acids. The deduced amino acid sequence presented the typical structural features of PDGF family members and the N-terminal signal peptide for secretion...
September 13, 2017: Gene
https://www.readbyqxmd.com/read/28916274/do-urinary-cystine-parameters-predict-clinical-stone-activity
#7
Justin I Friedlander, Jodi A Antonelli, Noah E Canvasser, Monica S C Morgan, Daniel Mollengarden, Sara Best, Margaret S Pearle
PURPOSE: An accurate urinary predictor of stone recurrence would be clinically advantageous for patients with cystinuria. A proprietary assay from Litholink® (Chicago, IL) measures cystine capacity as a potentially more reliable estimate of stone-forming propensity. The recommended capacity level to prevent stone formation, >150 mg/L, has not been directly correlated with clinical stone activity. Herein we investigated the relationship between urinary cystine parameters and clinical stone activity...
September 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28916214/management-of-acquired-nonmalignant-tracheoesophageal-fistula-surgical-pearls
#8
EDITORIAL
K Robert Shen
No abstract text is available yet for this article.
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28913813/pharmacotherapy-pearls-for-emergency-neurological-life-support
#9
Gretchen M Brophy, Theresa Human
The appropriate use of medications during Emergency Neurological Life Support (ENLS) is essential to optimize patient care. Important considerations when choosing the appropriate agent include the patient's organ function and medication allergies, potential adverse drug effects, drug interactions and critical illness and aging pathophysiologic changes. Critical medications used during ENLS include hyperosmolar therapy, anticonvulsants, antithrombotics, anticoagulant reversal and hemostatic agents, anti-shivering agents, neuromuscular blockers, antihypertensive agents, sedatives, vasopressors and inotropes, and antimicrobials...
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28912817/the-effects-of-vitamin-d-supplement-on-prevention-of-recurrence-of-preeclampsia-in-pregnant-women-with-a-history-of-preeclampsia
#10
Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi
INTRODUCTION: Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. METHOD AND MATERIALS: The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28912282/apparent-diffusion-coefficient-histograms-of-human-papillomavirus-positive-and-human-papillomavirus-negative-head-and-neck-squamous-cell-carcinoma-assessment-of-tumor-heterogeneity-and-comparison-with-histopathology
#11
T de Perrot, V Lenoir, M Domingo Ayllón, N Dulguerov, M Pusztaszeri, M Becker
BACKGROUND AND PURPOSE: Head and neck squamous cell carcinoma associated with human papillomavirus infection represents a distinct tumor entity. We hypothesized that diffusion phenotypes based on the histogram analysis of ADC values reflect distinct degrees of tumor heterogeneity in human papillomavirus-positive and human papillomavirus-negative head and neck squamous cell carcinomas. MATERIALS AND METHODS: One hundred five consecutive patients (mean age, 64 years; range, 45-87 years) with primary oropharyngeal (n = 52) and oral cavity (n = 53) head and neck squamous cell carcinoma underwent MR imaging with anatomic and diffusion-weighted sequences (b = 0, b = 1000 s/mm(2), monoexponential ADC calculation)...
September 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28904907/microdissection-testicular-sperm-extraction
#12
REVIEW
Ryan Flannigan, Phil V Bach, Peter N Schlegel
Microdissection testicular sperm extraction (microTESE) is considered the gold standard method for surgical sperm retrieval among patients with non-obstructive azoospermia (NOA). In this review, we will discuss the optimal evaluation of NOA patients and strategies to medically optimize NOA patients prior to microTESE. In addition, we will also discuss technical principles and pearls to maximize the chances of successful sperm retrieval, sperm retrieval rates (SRR) based upon testicular histology, predictors of successful sperm retrieval, gonadal recovery following microTESE, and potential complications...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28902748/pad-placement-pearl-for-metatarsalgia
#13
Valena C Martinez Sellers, Daniel C Herman
No abstract text is available yet for this article.
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28902121/critical-care-resources-in-guangdong-province-of-china-three-surveys-from-2005-to-2015
#14
Jian-Feng Wu, Fei Pei, Bin Ouyang, Juan Chen, Yi-Min Li, Yong-Wen Feng, Fa-Liang Guo, Li-Xin Zhou, Zheng Wang, Ying-Jun Guo, Qin-Han Lin, Zhan-Peng Li, Yun Ling, Li Li, Lie-Hua Deng, Ying-Ping Zhao, Jian-Wei Dai, Shu-Yu Luo, Dun-Rong Zhou, Wei-Wen Luo, Ling Zhao, Wei-Ying Chen, Wei-Chuan Wang, Wen-Yang Cai, Qiong-Xiang Luo, Xiang-Dong Guan
OBJECTIVES: Data about the critical care resources in China remain scarce. The purpose of this study was to investigate the variation and distribution of critical care resources in Guangdong province from 2005 to 2015. DESIGN: Data in regard to critical care resources were collected through questionnaires and visits every 5 years from 2005. SETTING: All hospitals in Guangdong province were screened and hospitals that provide critical care services were enrolled...
September 8, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28893645/a-novel-toll-like-receptor-from-the-pearl-oyster-pinctada-fucata-martensii-is-induced-in-response-to-stress
#15
Yuyuan Wu, Haiying Liang, Zhixin Wang, Qiannan Lei, Liqun Xia
Graft rejection due to immune incompatibility is a common occurrence in pearl culture, which often cause death to the host oyster. To improve cultured pearl production, host mortality and bead rejection rates must be reduced. Toll-like receptor 4 (TLR4) plays an important role in innate immunity, and may be related to allograft rejection. Here, we cloned the TLR4 cDNA from the pearl oyster Pinctada fucata martensii (PmTLR4). PmTLR4 cDNA was 3138bp, including a 2625bp open reading frame encoding 874 amino acids...
September 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28889930/radiologic-pearls-for-internists-a-case-based-review
#16
REVIEW
Melissa J McGettigan, Robert A Gatenby
Modern technologic advances in medical imaging and the increasing use of imaging across all disciplines in medicine have led to a striking rise in incidental findings unrelated to the original study indication. Often, these findings have no clinical relevance and will not impact the current or future health status of the patient. It is incumbent on radiologists to report these findings in a definitive and unambiguous manner. Similarly, it is essential for clinicians to restrain from further diagnostic investigation of incidental findings that are conclusive by imaging...
September 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28888442/fermented-pearl-millet-pennisetum-glaucum-with-in-vitro-dna-damage-protection-activity-bioactive-compounds-and-antioxidant-potential
#17
Raj Kumar Salar, Sukhvinder Singh Purewal, Kawaljit Singh Sandhu
In the present study, pearl millet cultivar PUSA-415 was fermented by solid state fermentation (SSF) process using Aspergillus sojae (MTCC-8779) as starter culture. The fermentation was carried out for the period of ten days. The effect of SSF on phenolic content, condensed tannin content, antioxidant potential and DNA damage protection of pearl millet during different fermentation period was determined. Results showed that SSF and thermal processing significantly affect the bioactive profile and antioxidant potential of bio-transformed pearl millet...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28887791/pearls-the-mobile-segment-in-sarcoma-resections
#18
R Lor Randall
No abstract text is available yet for this article.
September 8, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28886880/choice-of-technological-change-for-china-s-low-carbon-development-evidence-from-three-urban-agglomerations
#19
Pinrong Jia, Ke Li, Shuai Shao
China's three urban agglomerations, namely, "Beijing-Tianjin-Hebei", "Yangtze River Delta", and "Pearl River Delta", are the most developed regions in China. These agglomerations are also expected to play a leading role in China's low-carbon development. Energy-saving and carbon-free technological changes play key roles in the low-carbon development transformation of these regions. This study investigates the elasticities of the output and substitution of factors, and the biased technological change in the three urban agglomerations based on the stochastic frontier analysis with a translog production function...
September 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28886754/on-farm-biosecurity-practices-and-causes-of-preweaning-mortality-in-canadian-commercial-mink-kits
#20
Nicole Compo, David L Pearl, Brian Tapscott, Amanda Storer, Jutta Hammermueller, Marina Brash, Patricia V Turner
BACKGROUND: Mink are an important animal commodity group in Canada and excessive kit mortality represents a significant loss to production. National biosecurity standards have been developed for Canadian mink farms, but it is unclear how well these standards have been implemented as there are no studies correlating management practices of mink producers with causes of death in mink kits. To that end, we surveyed Ontario mink producers on their biosecurity and management practices and conducted almost 5660 post mortem examinations on found-dead, preweaned kits to characterize mink farm biosecurity practices and causes of death in preweaned kits...
September 8, 2017: Acta Veterinaria Scandinavica
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