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Breast ,axillary dissection

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https://www.readbyqxmd.com/read/28324891/multicenter-prospective-evaluation-of-the-reliability-of-the-combined-use-of-two-models-to-predict-non-sentinel-lymph-node-status-in-breast-cancer-patients-with-metastatic-sentinel-lymph-nodes-the-mskcc-nomogram-and-the-tenon-score-results-of-the-notegs-study
#1
Roman Rouzier, Catherine Uzan, Alexandra Rousseau, Eugénie Guillot, Sonia Zilberman, Charles Meyer, Pablo Estevez, Pierre-Francois Dupre, David Kere, Virginie Doridot, Gauthier D'halluin, Xavier Fritel, Nicolas Pouget, Clémentine Jankowski, Chafika Mazouni, Tabassome Simon, Charles Coutant
BACKGROUND: The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node dissection (ALND) could be avoided. METHODS: From January 2011 to July 2012, a prospective non-interventional nationwide study was conducted (NCT01509963). We sought to identify the false reassurance rate (FRR, a negative test result is false) in patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3...
March 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28295828/are-the-acosog-z0011-trial-findings-being-applied-to-breast-cancer-patients-undergoing-neoadjuvant-chemotherapy
#2
Olga Kantor, Catherine Pesce, Erik Liederbach, Chi-Hsiung Wang, David J Winchester, Katharine Yao
In 2010, the ACOSOG Z0011 trial showed equivalent survival and recurrence between sentinel lymph node biopsy (SLNB) alone versus axillary lymph node dissection (ALND) for those with a tumor positive sentinel node (SN). We examined national trends in axillary surgery following neoadjuvant chemotherapy (NAC) for clinically node positive disease in the years prior to and after the Z0011 trial publication. 12,063 women with cT1-4N1M0 invasive breast cancer who underwent NAC from 2006 to 2013 and had 1-3 positive nodes on pathology were selected from the National Cancer Data Base...
March 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28289662/mucosa-associated-lymphoid-tissue-lymphoma-of-the-cecum-and-rectum-a-case-report
#3
Myung Jin Nam, Byung Chang Kim, Sung Chan Park, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Weon Seo Park, Hee Jin Chang, Jae Hwan Oh
A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28280645/stewart-treves-syndrome-involving-chronic-lymphedema-after-mastectomy-of-breast-cancer
#4
Smain Nabil Mesli, Amin Khayreddine Ghouali, Fouad Benamara, Fouzi Ahmed Taleb, Hicham Tahraoui, Chakib Abi-Ayad
Steward-Treves syndrome is a cutaneous angiosarcoma that usually appears after long evolution of a lymphoedema after mastectomy for mammary neoplasia associated with an axillary dissection. This is a rare disease develop most of the time in upper arm and often confounded with cutaneous metastasis. Only the biopsy and immunohistochemical study confirm the diagnosis. The treatment is surgical and consists of large cutaneous excision, an amputation of the limb or even its disarticulation and will be followed by chemotherapy...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28272714/role-of-dwi-assessing-nodal-involvement-and-response-to-neoadjuvant-chemotherapy-in-advanced-breast-cancer
#5
P Belli, E Bufi, C Buccheri, P Rinaldi, M Giuliani, M Romani, G Fabrizi, A D'angelo, C Brunelli, A Mule', G Franceschini, C Colosimo
OBJECTIVE: To explore the role of diffusion-weighted imaging (DWI) in the staging of axillary lymph nodes and the restaging after neoadjuvant chemotherapy (NAD) in advanced breast cancer. PATIENTS AND METHODS: MRI examinations of forty-two patients diagnosed with advanced breast cancer addressed to NAD and axillary lymph node dissection (ALND) were reviewed. Apparent diffusion coefficients (ADC) of each visible node in DWI in the pathologic axilla (PA) and healthy axilla (HA) were measured at the time of diagnosis (t0) and after chemotherapy (t1); mean values of the ADC were calculated...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28267657/preoperative-radiotherapy-in-breast-cancer-patients-32%C3%A2-years-of-follow-up
#6
F G Riet, F Fayard, R Arriagada, M A Santos, C Bourgier, M Ferchiou, S Heymann, S Delaloge, C Mazouni, A Dunant, S Rivera
This study evaluates the long-term outcomes of a retrospective cohort of breast cancer (BC) patients who had received curatively intended premastectomy radiation therapy (RT). We analysed locoregional control, disease-free survival (DFS) and overall survival (OS), pathological complete remission (pCR), predictors thereof, and immediate safety. The series consisted of 187 patients with a median age of 49 years [43-60] and T2-T4 or N2 tumours. Between 1970 and 1984, they had received slightly hypofractionated RT to the whole breast, ipsilateral supraclavicular fossa and axilla ± the internal mammary chain (45-55 Gy/18 fractions of 2...
March 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28259045/development-and-validation-of-a-nomogram-for-predicting-survival-on-the-base-of-modified-lymph-node-ratio-in-breast-cancer-patients
#7
Jiahuai Wen, Yanning Yang, Peng Liu, Feng Ye, Hailin Tang, Xiaojia Huang, Shaowen Zhong, Xiaoming Xie
BACKGROUND: Axillary lymph node status is one of the most important prognostic factors in breast cancer and previous studies indicated that lymph node ratio (LNR) could better predict the outcome than the counting of positive lymph nodes. In the current study, we evaluated the prognostic effect of modified LNR in breast cancer patients. METHODS: A total of 3339 breast cancer patients undergoing axillary lymph nodes dissection were enrolled and respectively analyzed...
March 1, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28258414/what-to-do-with-non-visualized-sentinel-nodes-a-dutch-nationwide-survey-study
#8
Nicole C Verheuvel, Adri C Voogd, Vivianne C G Tjan-Heijnen, Rudi M H Roumen
INTRODUCTION: International guidelines differ regarding their recommendations on axillary treatment of patients with non-visualized sentinel lymph nodes (non-vSLN). Therefore, we distributed a survey among Dutch oncological surgeons to determine their routine practice and opinion regarding axillary treatment in case of a non-vSLN, with the emphasis on whether these practices and opinions have changed since publication of the Z0011 trial. METHODS: A Dutch nationwide survey containing 10 questions regarding clinical routine during the sentinel node procedure and axillary treatment of non-vSLN patients was distributed among 510 oncological surgeons...
March 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28254641/role-of-total-tumour-load-of-sentinel-lymph-node-on-survival-in-early-breast-cancer-patients
#9
Vicente Peg, Irene Sansano, Begoña Vieites, Laia Bernet, Rafael Cano, Alicia Córdoba, Magdalena Sancho, María Dolores Martín, Felip Vilardell, Alicia Cazorla, Martín Espinosa-Bravo, José Manuel Pérez-García, Javier Cortés, Isabel T Rubio, Santiago Ramón Y Cajal
BACKGROUND: Axillary staging (pN) is considered one of the most important prognostic factors in breast cancer patients. However, the Z0011 study data drastically reduced the number of surgical axillary dissections in a selected group of patients, limiting the prognostic information relating to axillary involvement to the sentinel lymph node (SLN). It is known that there is a relationship between SLN total tumour load (TTL) and axillary involvement. The objective of this study is to analyse the relationship between the TTL and outcomes in patients with early stage breast cancer...
February 27, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28241044/medico-economic-impact-of-mskcc-non-sentinel-node-prediction-nomogram-for-er-positive-her2-negative-breast-cancers
#10
Hélène Bonsang-Kitzis, Delphine Mouttet-Boizat, Eugénie Guillot, Jean-Guillaume Feron, Virginie Fourchotte, Séverine Alran, Jean-Yves Pierga, Paul Cottu, Florence Lerebours, Denise Stevens, Anne Vincent-Salomon, Brigitte Sigal-Zafrani, François Campana, Roman Rouzier, Fabien Reyal
BACKGROUND: Avoiding axillary lymph node dissection (ALND) for invasive breast cancers with isolated tumor cells or micrometastatic sentinel node biopsy (SNB) could decrease morbidity with minimal clinical significance. PURPOSE: The aim of this study is to simulate the medico-economic impact of the routine use of the MSKCC non-sentinel node (NSN) prediction nomogram for ER+ HER2- breast cancer patients. METHODS: We studied 1036 ER+ HER2- breast cancer patients with a metastatic SNB...
2017: PloS One
https://www.readbyqxmd.com/read/28228695/accessory-joint-and-neural-mobilizations-for-shoulder-range-of-motion-restriction-after-breast-cancer-surgery-a-pilot-randomized-clinical-trial
#11
Irene de la Rosa Díaz, María Torres Lacomba, Ester Cerezo Téllez, Cristina Díaz Del Campo Gómez-Rico, Carlos Gutiérrez Ortega
OBJECTIVE: The aim of this study was to assess the methods to conduct a substantive clinical trial to evaluate the effects of accessory joint mobilization (AJM) vs neural mobilization (NM) techniques for shoulder motion restriction after breast cancer surgery. METHODS: This pilot study was a prospective randomized and double-blind clinical trial in which 18 women who underwent unilateral breast cancer surgery and axillary lymph node dissection participated. The study was conducted at the Women's Health Research Group at the Physical Therapy Department of Alcalá University, Madrid, Spain...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28224384/swedish-prospective-multicenter-trial-evaluating-sentinel-lymph-node-biopsy-after-neoadjuvant-systemic-therapy-in-clinically-node-positive-breast-cancer
#12
Linda Holmstrand Zetterlund, Jan Frisell, Athanasios Zouzos, Rimma Axelsson, Thomas Hatschek, Jana de Boniface, Fuat Celebioglu
PURPOSE: Patients with clinically node-positive breast cancer planned for neoadjuvant systemic therapy (NAST) may draw advantages from the nodal downstaging effect and reduce the extent of axillary surgery with sentinel lymph node biopsy (SLNB) performed after NAST. Since there are concerns about lower sentinel lymph node (SLN) detection and higher false-negative rates (FNR) in this setting, our aim was to define the accuracy of SLNB after NAST. METHODS: This Swedish national multicenter trial prospectively recruited 195 breast cancer patients from ten hospitals with T1-T4d biopsy-proven node-positive disease planned for NAST between October 1, 2010 and December 31, 2015...
February 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28222936/36-cases-adenoid-cystic-carcinoma-of-the-breast-in-china-comparison-with-matched-grade-one-invasive-ductal-carcinoma-not-otherwise-specified
#13
Shuling Wang, Weidong Li, Fang Wang, Yun Niu, Chunfang Hao, Xu Wang, Lihong He, Zhongsheng Tong
OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristic of adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: The clininopathological features, along with relapse free survival(RFS) and overall survival(OS) of 36 patients with ACC were retrospectively investigated and compared with those of 108 grade 1 invasive ductal carcinoma not-otherwise-specified (G1-IDC-NOS) patients. RESULTS: Most cases of ACC were ER, PR and HER-2 negative which was classified as triple-negative subtype...
January 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214005/-review-of-national-and-international-guidelines-for-sentinel-lymph-node-biopsy-and-complementary-axillary-dissection-in-breast-cancer
#14
REVIEW
Laura Vincent, François Margueritte, Jennifer Uzan, Clémentine Owen, Julien Seror, Nicolas Pouget, Eugénie Guillot, Roman Rouzier
Management of breast cancer is based on national and international guidelines. These are defined on evidence-based medicine. The main purpose of this review is to compare the different guidelines for sentinel lymph node biopsy and completion axillary dissection after positive sentinel lymph node biopsy. This review of breast cancer guidelines led to identify consensus, but in some specific situations, they differ. The guidelines cannot be applied to all clinical cases, mandatoring multidisciplinary meetings are essential...
February 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28213782/prognosis-of-residual-axillary-disease-after-neoadjuvant-chemotherapy-in-clinically-node-positive-breast-cancer-patients-isolated-tumor-cells-and-micrometastases-carry-a-better-prognosis-than-macrometastases
#15
T J A van Nijnatten, J M Simons, M Moossdorff, L de Munck, M B I Lobbes, C C van der Pol, L B Koppert, E J T Luiten, M L Smidt
PURPOSE: The aim of this study was to compare disease-free survival (DFS) and overall survival (OS) between clinically node-positive breast cancer patients, treated with neoadjuvant chemotherapy (NAC), with axillary pathologic complete response (ypN0), residual axillary isolated tumor cells or micrometastases (ypNitc/mi), and residual axillary macrometastases (ypN1-3). METHODS: All patients diagnosed with clinically node-positive primary invasive breast cancer treated with NAC and subsequent axillary lymph node dissection between 2005 and 2008 were retrospectively analyzed...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28213781/swedish-prospective-multicenter-trial-on-the-accuracy-and-clinical-relevance-of-sentinel-lymph-node-biopsy-before-neoadjuvant-systemic-therapy-in-breast-cancer
#16
Linda Zetterlund, Fuat Celebioglu, Rimma Axelsson, Jana de Boniface, Jan Frisell
PURPOSE: The timing of sentinel lymph node biopsy (SLNB) in the context of neoadjuvant systemic therapy (NAST) in breast cancer is still controversial. SLNB before NAST has been evaluated in few single-institution studies in which axillary lymph node dissection (ALND), however, was commonly not performed in case of a negative SLNB. We investigated the potential clinical relevance of SLNB before NAST by performing ALND in all patients after NAST. METHODS: This national multicenter trial prospectively enrolled clinically node-negative breast cancer patients planned for NAST at 13 recruiting Swedish hospitals between October 2010 and December 2015...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28210920/choosing-the-appropriate-side-for-subcutaneous-port-catheter-placement-in-patients-with-mastectomy-ipsilateral-or-contralateral
#17
Omer Fatih Nas, Kadir Hacikurt, Ahmet Kaya, Nurullah Dogan, Bekir Sanal, Guven Ozkaya, Halit Ziya Dundar, Cuneyt Erdogan
PURPOSE: To evaluate long-term clinical follow-up results of implanting subcutaneous port catheters (SPCs) on ipsilateral or contralateral with mastectomy side in patients with axillary lymph node dissection. METHODS: A total of 73 patients composed of ipsilateral (34 catheters) and contralateral (39 catheters) groups, with SPCs were included. All patients had lumpectomy or modified radical mastectomy for breast cancer. Ipsilateral and contralateral groups had similar patient characteristics...
February 17, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28195257/pathological-complete-response-in-a-patient-affected-by-multiple-synchronous-breast-and-lung-primary-malignancies-a-case-report-and-review-of-the-literature
#18
A Nottegar, C Luchini, S Cingarlini, S Beccari, E Grego, E Gilioli, E Manfrin, F Bonetti
A pathological complete response in a patient affected by multiple synchronous, breast and lung primary malignancies is reported. A 63-year-old woman presented with an invasive ductal carcinoma of the breast and a lung adenocarcinoma. After multidisciplinary discussion, the patient underwent pulmonary left lower lobectomy followed by radio-chemotherapy with cisplatin and vinorelbine and started hormone therapy with letrozole. Ten months later, a left mastectomy with axillary lymph nodes dissection was performed...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28187209/a-cut-off-of-2150-cytokeratin-19-mrna-copy-number-in-sentinel-lymph-node-may-be-a-powerful-predictor-of-non-sentinel-lymph-node-status-in-breast-cancer-patients
#19
Irene Terrenato, Valerio D'Alicandro, Beatrice Casini, Letizia Perracchio, Francesca Rollo, Laura De Salvo, Simona Di Filippo, Franco Di Filippo, Edoardo Pescarmona, Marcello Maugeri-Saccà, Marcella Mottolese, Simonetta Buglioni
Since 2007, one-step nucleic acid amplification (OSNA) has been used as a diagnostic system for sentinel lymph node (SLN) examination in patients with breast cancer. This study aimed to define a new clinical cut-off of CK19 mRNA copy number based on the calculation of the risk that an axillary lymph node dissection (ALND) will be positive. We analyzed 1529 SLNs from 1140 patients with the OSNA assay and 318 patients with positive SLNs for micrometastasis (250 copies) and macrometastasis (5000 copies) underwent ALND...
2017: PloS One
https://www.readbyqxmd.com/read/28187025/de-novo-upper-extremity-lymphedema-after-elective-hand-surgery-in-breast-cancer-survivors
#20
Heather L Baltzer, Jamison Harvey, Paige M Fox, Steven L Moran
BACKGROUND: The safety of elective hand surgery in breast cancer (BC) survivors is controversial because of concerns of developing upper extremity lymphedema. This study aimed to evaluate the risk of developing lymphedema after elective hand surgery among patients that underwent ipsilateral axillary lymph node dissection (ALND), sentinel lymph node biopsy (SLNB), and/or radiation therapy (RT). METHOD: A retrospective cohort of BC patients treated with ALND, SLNB, and/or RT was identified (1997-2012)...
February 10, 2017: Annals of Plastic Surgery
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