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https://www.readbyqxmd.com/read/28728401/research-trends-in-outdoor-pig-production
#1
Hyun-Suk Park, Sang Hyon Oh
Since the industrialization of swine production in the late 1900s, swine farms in the United States, as well as in Europe, have largely become consolidated. Pig farms became larger in size but fewer in number, with 91% of market pigs being produced by large operations with 5,000 or more pigs on-site in the US, and only 3% of the total utilized agricultural land representing organic farming. Such change in the market made it difficult for small farmers to stay competitive, forcing them to find alternative ways to reduce the cost of production and increase profit using the outdoor production system...
July 17, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28728128/radionuclide-biokinetics-in-the-russian-sturgeon-and-phylogenetic-consistencies-with-cartilaginous-and-bony-marine-fishes
#2
Ross A Jeffree, Scott J Markich, Francois Oberhaensli, Jean-Louis Teyssie
The biokinetics of eight radionuclides ((241)Am, (109)Cd, (134)Cs, (75)Se, (54)Mn, (110m)Ag, (65)Zn, (60)Co) absorbed from the aquatic medium by juvenile Russian sturgeon (Acipenser gueldenstaedtii) were experimentally determined in fresh (0.42‰) and brackish (9.0‰) waters, of a similar salinity range to the Caspian Sea, and in conjunction with chemical speciation modelling. Uptake and loss rate constants were determined for each radionuclide for a 14 day exposure at each salinity and during 28 days of exposure to radionuclide-free conditions...
July 17, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28728109/zero-valent-aluminum-for-reductive-removal-of-aqueous-pollutants-over-a-wide-ph-range-performance-and-mechanism-especially-at-near-neutral-ph
#3
Shiying Yang, Di Zheng, Tengfei Ren, Yixuan Zhang, Jia Xin
Zero-valent aluminum (ZVAl) draws much attention due to its strong reducibility. However, under neutral pH conditions, the reduction ability of ZVAl for pollutant removal has still been suspected because of the formed compact surface film of Al-(hydr)oxide. In this study, unmodified ZVAl was employed to reductively remove aqueous pollutants over a wide pH range, and its performance and mechanism, especially at near-neutral pH, were systematically studied for the first time. Results demonstrated that ZVAl had a wide range of pH applicability from 2 to 12, even in neutral environment...
July 6, 2017: Water Research
https://www.readbyqxmd.com/read/28728027/highly-sensitive-response-of-solution-processed-bismuth-sulfide-nanobelts-for-room-temperature-nitrogen-dioxide-detection
#4
Hao Kan, Min Li, Zhilong Song, Sisi Liu, Baohui Zhang, Jingyao Liu, Ming-Yu Li, Guangzu Zhang, ShengLin Jiang, Huan Liu
Low dimensional nanomaterials have emerged as candidates for gas sensors owing to their unique size-dependent properties. In this paper, Bi2S3 nanobelts were synthesized via a facile solvothermal process and spin-coated onto alumina substrates at room temperature. The conductometric devices can even sensitively response to the relatively low concentrations of NO2 at room temperature, and their sensing performance can be effectively enhanced by the ligand exchange treatment with inorganic salts. The Pb(NO3)2-treated device exhibited superior sensing performance of 58...
July 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28727871/biosimilars-in-oncology-in-the-united-states-a-review
#5
Chadi Nabhan, Sandeep Parsad, Anthony R Mato, Bruce A Feinberg
Importance: Biosimilars are biological medicines that contain a highly similar version of the active substance of an already approved biologic reference product. The availability of biosimilars might provide an opportunity to lower health care expenditures as a result of the inherent price competition with their reference product. Understanding how biosimilar cancer drugs are regulated, approved, and paid for, as well as their impact in a value-based care environment, is essential for physicians and other stakeholders in oncology...
July 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28727688/diazepam-actions-in-the-vta-enhance-social-dominance-and-mitochondrial-function-in-the-nucleus-accumbens-by-activation-of-dopamine-d1-receptors
#6
M A van der Kooij, F Hollis, L Lozano, I Zalachoras, S Abad, O Zanoletti, J Grosse, I Guillot de Suduiraut, C Canto, C Sandi
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines' effects in social competition are not understood. Converging evidence points to the mesolimbic system as a potential site of action for at least some benzodiazepine-mediated effects. Furthermore, mitochondrial function in the nucleus accumbens (NAc) has been causally implicated in the link between anxiety and social competitiveness...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28727565/danoc-an-efficient-algorithm-and-hardware-codesign-of-deep-neural-networks-on-chip
#7
Xichuan Zhou, Shengli Li, Fang Tang, Shengdong Hu, Zhi Lin, Lei Zhang
Deep neural networks (NNs) are the state-of-the-art models for understanding the content of images and videos. However, implementing deep NNs in embedded systems is a challenging task, e.g., a typical deep belief network could exhaust gigabytes of memory and result in bandwidth and computational bottlenecks. To address this challenge, this paper presents an algorithm and hardware codesign for efficient deep neural computation. A hardware-oriented deep learning algorithm, named the deep adaptive network, is proposed to explore the sparsity of neural connections...
July 18, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28727537/state-health-agency-and-local-health-department-workforce-identifying-top-development-needs
#8
Angela J Beck, Jonathon P Leider, Fatima Coronado, Elizabeth Harper
OBJECTIVES: To identify occupations with high-priority workforce development needs at public health departments in the United States. METHODS: We surveyed 46 state health agencies (SHAs) and 112 local health departments (LHDs). We asked respondents to prioritize workforce needs for 29 occupations and identify whether more positions, more qualified candidates, more competitive salaries for recruitment or retention, or new or different staff skills were needed. RESULTS: Forty-one SHAs (89%) and 36 LHDs (32%) participated...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28727505/opportunities-and-benefits-for-powerchair-users-through-power-soccer
#9
Michael S Jeffress, William J Brown
Power soccer (or powerchair football), the first competitive team sport for users of motorized wheelchairs, is receiving increased attention among people with disabilities, healthcare professionals, and academics. The present study provides a qualitative analysis of the experiences of 34 American power soccer athletes. Participant observation and in-depth interviews with 11 female and 23 male athletes were conducted between 2007 and 2013. Results indicate that involvement in power soccer provides participants with an increased sense of empowerment, acquisition of social capital, and psychosocial benefits, including a deep satisfaction of the desire to participate in competitive sports and an opportunity to be independent...
July 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28727281/defaunation-leads-to-interaction-deficits-not-interaction-compensation-in-an-island-seed-dispersal-network
#10
Evan C Fricke, Joshua J Tewksbury, Haldre S Rogers
Following defaunation, the loss of interactions with mutualists such as pollinators or seed dispersers may be compensated through increased interactions with remaining mutualists, ameliorating the negative cascading impacts on biodiversity. Alternatively, remaining mutualists may respond to altered competition by reducing the breadth or intensity of their interactions, exacerbating negative impacts on biodiversity. Despite the importance of these responses for our understanding of the dynamics of mutualistic networks and their response to global change, the mechanism and magnitude of interaction compensation within real mutualistic networks remains largely unknown...
July 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28726930/competition-and-selectivity-in-supramolecular-synthesis-structural-landscape-around-1-pyridylmethyl-2-2-biimidazoles
#11
C A Gunawardana, J Desper, A S Sinha, M Ðaković, C B Aakeröy
Three isomeric forms of 1-(pyridylmethyl)-2,2'-biimidazole, A1-A3, have been synthesized and subjected to systematic co-crystallizations with selected hydrogen- and halogen-bond donors in order to explore the impact of electrostatics and geometry on the resulting supramolecular architectures. The solid-state supramolecular behavior of A1-A3 is largely consistent in halogen-bonded co-crystals. Only two types of primary interactions, the N-HN/NH-N homomeric hydrogen-bond interactions responsible for the pairing of biimidazole moieties and the IN(pyridine) halogen bonds responsible for the co-crystal formation and structure extension, are present in these systems...
July 20, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28726759/high-resolution-inhibition-profiling-combined-with-hplc-hrms-spe-nmr-for-identification-of-ptp1b-inhibitors-from-vietnamese-plants
#12
Binh Thi Dieu Trinh, Anna K Jäger, Dan Staerk
Protein tyrosine phosphatase 1B (PTP1B) plays a key role as a negative regulator in insulin signal transduction by deactivating the insulin receptor. Thus, PTP1B inhibition has emerged as a potential therapeutic strategy for curing insulin resistance. In this study, 40 extracts from 18 different plant species were investigated for PTP1B inhibitory activity in vitro. The most promising one, the EtOAc extract of Ficus racemosa, was investigated by high-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR analysis...
July 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28726710/using-amine-functionalized-magnetite-hollow-nanospheres-amhns-as-adsorbents-for-heavy-metal-ions
#13
Sen Lin, Lili Liu, Yong Yang, Wei Zhang, Meng Xu, Kuangfei Lin
In this paper, the amine-functionalized magnetite hollow nanospheres (AMHNs), prepared through a facile one-pot synthesis, were used as heavy metal ion adsorbents, whose morphology and physicochemical features were exploring by transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction and Fourier-transform infrared analyses. Its adsorption performances for Pb(2+), Cu(2+), Zn(2+), Ni(2+) and Cd(2+) were studied in detail. The adsorption increased with the increase of initial pH value of the solution and could be obviously affected by ionic strength...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726703/high-performance-magnetic-chicken-bone-based-biochar-for-efficient-removal-of-rhodamine-b-dye-and-tetracycline-competitive-sorption-analysis
#14
Akeem Adeyemi Oladipo, Ayodeji Olugbenga Ifebajo, Numrah Nisar, Olusegun Ayoola Ajayi
Magnetic chicken bone-based biochar (MCBB) was successfully prepared and efficiently adsorbed rhodamine-B (RB) dye and tetracycline (TC) in multi-component systems. The magnetisation value, surface area, and pHpzc of the MCBB were found to be 66.5 emu/g, 328 m(2)/g, and 8.3, respectively. RB has higher saturation capacity (96.5 mg/g) and occupies more active sites on MCBB, thus limiting the sorption of TC with lower saturation capacity (63.3 mg/g). Langmuir isotherm suitably describes the sorption process in a single-component system; however, the multi-component system was well fitted to the Sheindorf-Rebhun-Sheintuch model...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726524/subnanomolar-indazole-5-carboxamide-inhibitors-of-monoamine-oxidase-b-mao-b-continued-indications-of-iron-binding-experimental-evidence-for-optimised-solubility-and-brain-penetration
#15
Nikolay T Tzvetkov, Liudmil Antonov
Pharmacological and physicochemical studies of N-unsubstituted indazole-5-carboxamides (subclass I) and their structurally optimised N1-methylated analogues (subclass II), initially developed as drug and radioligand candidates for the treatment and diagnosis of Parkinson's disease (PD), are presented. The compounds are highly brain permeable, selective, reversible, and competitive monoamine oxidase B (MAO-B) inhibitors with improved water-solubility and subnanomolar potency (pIC50 >8.8). Using a well-validated, combined X-ray/modelling technology platform, we performed a semi-quantitative analysis of the binding modes of all compounds and investigated the role of the indazole N1 position for their MAO-B inhibitory activity...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28726514/increased-blood-8-hydroxy-2-deoxyguanosine-levels-in-methamphetamine-users-during-early-abstinence
#16
Ming-Chyi Huang, Ying-Ching Lai, Shih-Ku Lin, Chun-Hsin Chen
BACKGROUND: Reactive oxygen species (ROS) are thought to play a role in the adverse physical and mental consequences of methamphetamine usage. The oxidative DNA adduct 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a well-known biomarker of ROS-induced DNA damage. Currently, there is insufficient clinical information about methamphetamine-induced oxidative DNA damage. OBJECTIVES: This study examined differences in blood levels of 8-OHdG between methamphetamine users and non-users as well as alterations in 8-OHdG levels after 2 weeks of methamphetamine abstinence...
July 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28726509/soymilk-fermentation-by-enterococcus-faecalis-vb43-leads-to-reduction-in-the-immunoreactivity-of-allergenic-proteins-%C3%AE-conglycinin-7s-and-glycinin-11s
#17
V Biscola, A Rodriguez de Olmos, Y Choiset, H Rabesona, M S Garro, F Mozzi, J-M Chobert, M Drouet, T Haertlé, B D G M Franco
Food allergies represent a serious problem affecting human health and soy proteins rank among the most allergenic proteins from food origin. The proteolytic enzymes produced by lactic acid bacteria (LAB) can hydrolyse the major allergens present in soybean, reducing their immunoreactivity. Many studies have reported the ability of LAB to ferment soy-based products; while the majority of them focus on the improvement of the sensory characteristics and functionality of soy proteins, a lack of information about the role of lactic fermentation in the reduction of immunoreactivity of these proteins exists...
July 20, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28726389/anti-melanogenic-effect-of-urolithin-a-and-urolithin-b-the-colonic-metabolites-of-ellagic-acid-in-b16-melanoma-cells
#18
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su
Anti-melanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and anti-aging effects. In this study, the metabolites were found to possess depigmentation efficacy by suppressing tyrosinase activity. Both UA and UB could attenuate melanogenesis in B16 melanoma cells at non-cytotoxic doses, and UA showed comparable efficacy to positive control, kojic acid group...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726303/the-ecology-of-white-handed-and-pileated-gibbons-in-a-zone-of-overlap-and-hybridization-in-thailand
#19
Norberto Asensio, Juan Manuel José-Domínguez, Chalita Kongrit, Warren Y Brockelman
OBJECTIVES: The study of related species in contact zones can elucidate what factors mediate species coexistence and geographical distributions. We investigated niche overlap and group interactions of two gibbon species and their hybrids co-occurring in a zone of overlap and hybridization. METHODS: The location, composition and behavior of white-handed, pileated, and mixed-species gibbon groups were studied by following them during 31 consecutive months in a relatively large part of the contact zone...
August 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28726132/phase-i-dose-escalation-study-of-nms-1286937-an-orally-available-polo-like-kinase-1-inhibitor-in-patients-with-advanced-or-metastatic-solid-tumors
#20
Glen J Weiss, Gayle Jameson, Daniel D Von Hoff, Barbara Valsasina, Cristina Davite, Claudia Di Giulio, Francesco Fiorentini, Rachele Alzani, Patrizia Carpinelli, Alessandro Di Sanzo, Arturo Galvani, Antonella Isacchi, Ramesh K Ramanathan
Background Pharmacological inhibition of polo-like kinase 1 (PLK1) represents a new approach for the treatment of solid tumors. This study was aimed at determining the first cycle dose-limiting toxicities (DLTs) and related maximum tolerated dose (MTD) of NMS-1286937, a selective ATP-competitive PLK1-specific inhibitor. Secondary objectives included evaluation of its safety and pharmacokinetic (PK) profile in plasma, its antitumor activity, and its ability to modulate intracellular targets in biopsied tissue...
July 20, 2017: Investigational New Drugs
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