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https://www.readbyqxmd.com/read/29161759/asymmetry-during-functional-movement-screening-and-injury-risk-in-junior-football-players-a-replication-study
#1
Samuel Chalmers, Thomas A Debenedictis, Andrew Zacharia, Samuel Townsley, Cara Gleeson, Matthew Lynagh, Alex Townsley, Joel T Fuller
An indicator of movement quality and potential injury risk during Functional Movement Screen (FMS) testing is the presence of asymmetry when comparing the left and right sides of the body. The aim of the study was to investigate the reproducibility of the injury risk model proposed in our previous research (Chalmers et al. 2017; derivation study) that showed an increased injury risk for elite junior Australian football players demonstrating ≥2 asymmetrical FMS sub-tests. We used a direct replication design...
November 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29161669/the-coastal-environment-affects-lead-and-sodium-uptake-by-the-moss-hypnum-cupressiforme-used-as-an-air-pollution-biomonitor
#2
Marie Renaudin, Sébastien Leblond, Caroline Meyer, Christophe Rose, Emeline Lequy
Several studies suggest that potential competition exists between marine cations and heavy metals for binding sites on the cell wall of mosses. This competition would impact the heavy metal concentration measured in mosses by biomonitoring programs, which may underestimate air pollution by heavy metals in a coastal environment. In the present study, we aim to identify possible mechanisms affecting lead uptake by mosses in a coastal environment, specifically, the competition between lead (Pb(2+)) and sodium (Na(+)) for binding sites in Hypnum cupressiforme (Hc)...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29161634/shielding-effect-in-protein-folding
#3
Adam K Sieradzan, Agnieszka G Lipska, Emilia A Lubecka
One of the most important interactions responsible for protein folding and stability are hydrogen bonds between peptide groups. There is a constant competition between the water molecules and peptide groups in a hydrogen bond formation. Also side-chains take part in this process by reducing hydration of peptide group (shielding effect) that promotes the protein folding. In this paper, a new approach to take into account a shielding effect is presented. A modification of the energy function is derived and incorporated into the UNited RESidue (UNRES) force field...
November 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29161496/ion-transport-across-biological-membranes-by-carborane-capped-gold-nanoparticles
#4
Marcin P Grzelczak, Stephen P Danks, Robert C Klip, Domagoj Belic, Adnana Zaulet, Casper Kunstmann-Olsen, Dan F Bradley, Tatsuya Tsukuda, Clara Viñas, Francesc Teixidor, Jonathan J Abramson, Mathias Brust
2-3 nm carborane-capped gold nanoparticles (Au/carborane NPs) can act as artificial ion transporters across biological membranes. The particles themselves are large hydrophobic anions that have the ability to disperse in aqueous media and to partition over both sides of a phospholipid bilayer membrane. Their presence therefore causes a membrane potential that is determined by the relative concentrations of particles on each side of the membrane according to the Nernst-Equation. The particles tend to adsorb to both sides of the membrane and can flip across if changes in membrane potential require their repartitioning...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29161335/shoulder-complaints-in-wheelchair-athletes-a-systematic-review
#5
Omar W Heyward, Riemer J K Vegter, Sonja de Groot, Lucas H V van der Woude
BACKGROUND: In recent years the popularity of disabled sports and competition among disabled athletes has grown considerably. With this rise in exposure of, and participation in wheelchair sports comes an increase in related stressors, including musculoskeletal load. External mechanical loading may increase the risk of shoulder complaints. The objective of this literature review was to 1) identify and describe the prevalence and/or incidence of shoulder complaints in wheelchair athletes in the literature, to 2) examine the factors and underlying mechanisms that could be potentially involved, and 3) provide some insights into the development of preventative measures...
2017: PloS One
https://www.readbyqxmd.com/read/29161226/development-of-competitive-enzyme-linked-immunosorbent-assays-for-antibody-detection-based-on-bluetongue-virus-monoclonal-antibodies
#6
Zhou Han, Zang Mingxin, Li Xuechun, Xu Yigang, Qiao Xinyuan, Wang Li, Cui Wen, Jiang Yanping, Li Yijing, Tang Lijie
Bluetongue is a ruminant infectious disease that is characterized by hyperpyrexia, leukocyte decrease and mucosal ulcerative inflammation changes. In this study, three segments of Bluetongue virus (BTV)-8 VP2 protein (BTV-8A, 8B, and 8C) were cloned into pET-28a (+) and pMAl-c5X vectors and expressed in Escherichia coli BL21 (DE3) as histidine (His)-tagged (His-8A/8B/8C) and maltose-binding protein (MBP)-tagged (MBP-8A/8B/8C) fusion proteins. After purification, His-8A/8B/8C were used to immunize BALB/mice and MBP-8A/8B/8C were used to screen for monoclonal antibody (mAb)-secreting hybridomas...
November 21, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29161185/medications-for-sleep-schedule-adjustments-in-athletes
#7
Matthew B Baird, Irfan M Asif
CONTEXT: Sleep schedule adjustments are common requirements of modern-day athletes. Many nonpharmacologic and pharmacologic strategies exist to facilitate circadian rhythm shifts to maximize alertness and performance during competition. This review summarizes the evidence for commonly used pharmacologic agents and presents recommendations for the sports medicine provider. EVIDENCE ACQUISITION: MEDLINE searches were performed using the following keywords: sleep aids, circadian rhythm adjustment, athletes and sleep, caffeine and sports, melatonin and athletes, and sleep aids and sports...
November 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29161013/intelligent-peptide-gathering-mechanical-arm-tames-wild-trojan-horse-peptides-for-the-controlled-delivery-of-cancer-nanotherapeutics
#8
Nian-Qiu Shi, Yan Li, Yong Zhang, Nan Shen, Ling Qi, Shu-Ran Wang, Xian-Rong Qi
Cell-penetrating peptides (CPPs), also called "Trojan-Horse" peptides, have been used for facilitating intracellular delivery of numerous diverse cargoes and even nanocarriers. However, the lack of targeting specificity ("wildness" or nonselectivity) of CPP-nanocarriers remains an intractable challenge for many in vivo applications. In this work, we used an intelligent "peptide-gathering mechanical arm" (Int PMA) to curb CPPs' wildness and enhance the selectivity of R9-liposome-based cargo delivery for tumor targeting...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160913/bigger-testes-increase-paternity-in-a-simultaneous-hermaphrodite-independently-of-the-sperm-competition-level
#9
Nikolas Vellnow, Lucas Marie-Orleach, Kira S Zadesenets, Lukas Schärer
All sexually reproducing organisms face the evolutionary optimization problem of how much of their limited resources they should invest into male versus female reproduction, i.e., the problem of sex allocation (Charnov, 1982). Consider, for example, producing the optimal offspring sex ratio in gonochoristic (separate-sexed) animals. Since during sexual reproduction both parents contribute the same amount of nuclear genetic material to the zygote, the total fitness of males and females-on the population level-has to be equal (Düsing, 1884; Fisher, 1930; Houston & McNamara, 2006; Queller, 2006)...
November 21, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29160869/an-electrochemical-microrna-sensing-platform-based-on-tungsten-diselenide-nanosheets-and-competitive-rna-rna-hybridization
#10
Ying-Xu Chen, Wen-Jing Zhang, Ke-Jing Huang, Mingbo Zheng, Ya-Cen Mao
In this work, we report an ultrasensitive electrochemical biosensor for microRNA-21 (miRNA-21) detection by using a competitive RNA-RNA hybridization configuration. A biotinylated miRNA of the self-same sequence with the target miRNA is mixed with the samples, and allowed competition with the target miRNA for a thiolated RNA probe immobilized onto a tungsten diselenide (WSe2) nanosheet modified electrode. Thereafter the current response is obtained by forming the hybridized biotinylated miRNA with streptavidin-horseradish peroxidase (HRP) conjugates to catalyze the H2O2 + hydroquinone (HQ) system...
November 21, 2017: Analyst
https://www.readbyqxmd.com/read/29160743/left-inferior-frontal-gyrus-sensitivity-to-phonetic-competition-in-receptive-language-processing-a-comparison-of-clear-and-conversational-speech
#11
Xin Xie, Emily Myers
The speech signal is rife with variations in phonetic ambiguity. For instance, when talkers speak in a conversational register, they demonstrate less articulatory precision, leading to greater potential for confusability at the phonetic level compared with a clear speech register. Current psycholinguistic models assume that ambiguous speech sounds activate more than one phonological category and that competition at prelexical levels cascades to lexical levels of processing. Imaging studies have shown that the left inferior frontal gyrus (LIFG) is modulated by phonetic competition between simultaneously activated categories, with increases in activation for more ambiguous tokens...
November 21, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29160554/digest-evolution-of-sperm-size-and-number-in-external-fertilizers
#12
Pedram Samani
Ejaculate evolution in externally fertilizing species is influenced by competition among sperm as well as the rate at which sperm and eggs encounter one another. Liao et al. (2017) found that ejaculate evolution in external fertilizers depended on spawning conditions. In anurans, gametes are released very close to eggs and are relatively protected from dispersal by water currents, thus sperm competition is more important. However, in fish, sperm-egg encounter rate plays a much more important role in ejaculate evolution because gametes may be easily dispersed when released into the aquatic environment...
November 21, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29160365/foraging-behavior-and-at-sea-distribution-of-white-tailed-tropicbirds-in-tropical-ocean
#13
L F A S Campos, A B Andrade, S Bertrand, M A Efe
We used miniaturized GPS loggers and site observations to access foraging patterns and nest behaviour of the White-tailed Tropicbird Phaethon lepturus (WTTB), an endangered species at its South Atlantic breeding colony. Dual foraging pattern was observed with alternation between long and short foraging trips. Birds responsible for nest attendance engaged in short foraging trips with mean distance from colony of 25 ± 17 km, total distance covered of 79 ± 65 km and mean duration of 4.02 ± 5.28 hours. Birds flew by dawn and returned before dusk while partners were at sea for long foraging trips that ranged from four to 11 days, with mean maximum distance from colony of 105 ± 47...
November 9, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29160027/identification-of-syntrophobacteraceae-as-major-acetate-degrading-sulfate-reducing-bacteria-in-italian-paddy-soil
#14
Pengfei Liu, Bianca Pommerenke, Ralf Conrad
Methane is an important greenhouse gas and acetate is the most important intermediate (average 70%) of the carbon flow to CH4 in paddy fields. Sulfate (e.g., gypsum) application can reduce CH4 emissions up to 70%. However, the effect of gypsum application on acetate degradation and the microbial communities involved are unclear. Therefore, we studied acetate-dependent sulfate reduction in anoxic microcosms of Italian rice paddy soil, combining profiling of 16S rRNA and dissimilatory sulfite reductase (dsrB) genes and transcripts and rRNA based stable isotope probing (SIP) analysis...
November 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29159602/competitive-advantage-of-mba-for-physician-executives-a-systematic-literature-review
#15
REVIEW
Anthony D Turner, Stanislaw P Stawicki, Weidun Alan Guo
In response to systemic challenges facing the US healthcare system, many medical students, residents and practicing physicians are pursuing a Master in Business Administration (MBA) degree. The value of such proposition remains poorly defined. The aim of this review is to analyze current literature pertaining to the added value of MBA training for physician executives (PEs). We hypothesized that physicians who supplement their clinical expertise with business education gain a significant competitive advantage...
November 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29159453/performance-of-secondary-p-fertilizers-in-pot-experiments-analyzed-by-phosphorus-x-ray-absorption-near-edge-structure-xanes-spectroscopy
#16
Christian Vogel, Camille Rivard, Verena Wilken, Andreas Muskolus, Christian Adam
A pot experiment was carried out with maize to determine the phosphorus (P) plant-availability of different secondary P-fertilizers derived from wastewater. We analyzed the respective soils by P K-edge X-ray absorption near-edge structure (XANES) spectroscopy to determine the P chemical forms that were present and determine the transformation processes. Macro- and micro-XANES spectroscopy were used to determine the chemical state of the overall soil P and identify P compounds in P-rich spots. Mainly organic P and/or P adsorbed on organic matter or other substrates were detected in unfertilized and fertilized soils...
November 20, 2017: Ambio
https://www.readbyqxmd.com/read/29159284/measuring-quantitative-effects-of-methylation-on-transcription-factor-dna-binding-affinity
#17
Zheng Zuo, Basab Roy, Yiming Kenny Chang, David Granas, Gary D Stormo
Methylation of CpG (cytosine-phosphate-guanine) dinucleotides is a common epigenetic mark that influences gene expression. The effects of methylation on transcription factor (TF) binding are unknown for most TFs and, even when known, such knowledge is often only qualitative. In reality, methylation sensitivity is a quantitative effect, just as changes to the DNA sequence have quantitative effects on TF binding affinity. We describe Methyl-Spec-seq, an easy-to-use method that measures the effects of CpG methylation (mCPG) on binding affinity for hundreds to thousands of variants in parallel, allowing one to quantitatively assess the effects at every position in a binding site...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29159229/interactions-of-manganese-with-iron-zinc-and-copper-in-neonatal-c57bl-6j-and-parkin-mice-following-developmental-oral-manganese-exposure
#18
Melanie L Foster, Thomas B Bartnikas, Hailey C Maresca-Fichter, Courtney Mercadante, Miriam Dash, Chelsea Miller, David C Dorman
High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wildtype strain (C57BL/6J) following neonatal Mn exposure. Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25 mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29159142/investigation-of-the-binding-mechanism-and-inhibition-of-bovine-liver-catalase-by-quercetin-multi-spectroscopic-and-computational-study
#19
Samaneh Rashtbari, Gholamreza Dehghan, Reza Yekta, Abolghasem Jouyban
Introduction: The study on the side effects of various drugs and compounds on enzymes is a main issue for monitoring the conformational and functional changes of them. Quercetin (3,5,7,3',4'-pentahydroxyflavone, QUE), a polyphenolic flavonoid, widely found in fruits, vegetables and it is used as an ingredient in foods and beverages. The interaction of bovine liver catalase (BLC) with QUE has been studied in this research by using different spectroscopic methods. Methods: In this work, the interaction of QUE with BLC was investigated using different spectroscopic methods including ultraviolet-visible (UV-vis) absorption, circular dichroism (CD) and fluorescence spectroscopy and molecular docking studies...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/29159025/comparison-of-the-inhibition-potentials-of-icotinib-and-erlotinib-against-human-udp-glucuronosyltransferase-1a1
#20
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug-drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI risks via UGT1A1 inhibition. The results demonstrated that both icotinib and erlotinib are UGT1A1 inhibitors, but the inhibitory effect of icotinib on UGT1A1 is weaker than that of erlotinib...
November 2017: Acta Pharmaceutica Sinica. B
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