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https://www.readbyqxmd.com/read/29351626/neuroendovascular-fellowship-training-self-assessment-of-a-program-accredited-by-the-committee-on-advanced-subspecialty-training
#1
Hakeem J Shakir, Hussain Shallwani, Leonardo Rangel-Castilla, Amade Bregy, Jason M Davies, Ashish Sonig, Christopher S Ogilvy, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy
The University at Buffalo's neuroendovascular fellowship is one of the longest running fellowship programs in North America. The burgeoning neurointerventional workforce and the rapid growth in the neurointerventional space on the heels of groundbreaking clinical trials prompted us to assess the fellowship's academic impact and its graduates' perceptions and productivity. An anonymized web-based survey was sent to all former neuroendovascular fellows with specific questions pertaining to current practice, research and funding, and perceptions about the fellowship's impact on their skills, competitiveness, and compensation...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29351385/development-of-a-recombinase-polymerase-amplification-assay-for-vibrio-parahaemolyticus-detection-with-an-internal-amplification-control
#2
Huanlan Yang, Shuang Wei, Ravi Gooneratne, Anthony N Mutukumirad, Xuejun Ma, Shuze Tang, Xiyang Wu
A novel RPA-IAC assay using recombinase polymerase and an internal amplification control (IAC) for Vibrio parahaemolyticus detection was developed. Specific primers were designed based on the coding sequence (CDS) for the toxR gene in V. parahaemolyticus. The recombinase polymerase amplification (RPA) reaction was conducted at a constant low temperature of 37°C for 20 min. Assay specificity was validated by using 63 Vibrio strains and 10 non-Vibrio bacterial species. In addition, a competitive IAC was employed to avoid false-negative results, which co-amplified simultaneously with the target sequence...
January 19, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29351274/dna-polymerase-iv-primarily-operates-outside-of-dna-replication-forks-in-escherichia-coli
#3
Sarah S Henrikus, Elizabeth A Wood, John P McDonald, Michael M Cox, Roger Woodgate, Myron F Goodman, Antoine M van Oijen, Andrew Robinson
In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in motion a series of different DNA repair and damage tolerance pathways. DNA polymerase IV (pol IV) is one of three specialised DNA polymerases called into action during the SOS response to help cells tolerate certain types of DNA damage. The canonical view in the field is that pol IV primarily acts at replisomes that have stalled on the damaged DNA template. However, the results of several studies indicate that pol IV also acts on other substrates, including single-stranded DNA gaps left behind replisomes that re-initiate replication downstream of a lesion, stalled transcription complexes and recombination intermediates...
January 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29351166/the-neuromuscular-biochemical-endocrine-and-mood-responses-to-small-sided-games-training-in-professional-soccer
#4
Sparkes W, Turner An, Weston M, Russell M, Johnston Mj, Kilduff Lp
The 24h responses to small-sided games (SSG) soccer training were characterized. Professional soccer players (n=16) performed SSG's (4vs4 + goalkeepers; 6x7-min, 2-min inter-set recovery) with performance (peak-power output, PPO; jump height, JH), physiological (blood creatine kinase: CK, lactate; salivary testosterone, cortisol), and mood measures collected before (baseline), and after (immediately; 0h, +2h, +24h). For PPO and JH, possibly small-moderate reductions occurred at 0h (-1.1W·kg; ±0.9W·kg, -3...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29351017/temperature-dependent-species-interactions-shape-priority-effects-and-the-persistence-of-unequal-competitors
#5
Tess Nahanni Grainger, Adam Ivan Rego, Benjamin Gilbert
The order of species arrival at a site can determine the outcome of competitive interactions when early arrivers alter the environment or deplete shared resources. These priority effects are predicted to be stronger at high temperatures, as higher vital rates caused by warming allow early arrivers to more rapidly impact a shared environment. We tested this prediction using a pair of congeneric aphid species that specialize on milkweed plants. We manipulated temperature and arrival order of the two aphid species and measured aphid population dynamics and milkweed survival and defensive traits...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29351014/coinfection-timing-drives-host-population-dynamics-through-changes-in-virulence
#6
Katherine M Marchetto, Alison G Power
Infections of one host by multiple parasites are common, and several studies have found that the order of parasite invasion can affect both within-host competition and disease severity. However, it is unclear to what extent coinfection timing might be important to consider when modeling parasite impacts on host populations. Using a model system of two viruses infecting barley, we found that simultaneous infections of the two viruses were significantly more damaging to hosts than sequential coinfections. While priority effects were evident in within-host concentrations of sequential coinfections, priority did not influence any parameters (such as virulence or transmission rate) that affect host population dynamics...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29350923/casscf-calculations-reveal-competitive-chair-pericyclic-and-boat-pseudopericyclic-transition-states-for-the-3-3-sigmatropic-rearrangement-of-allyl-esters
#7
Henry W Kreiman, Mackenzie E Batali, Cooper Jamieson, Molly A Lyon, James Alan Duncan
(10,8)CASPT2/6-31G**//(10,8)CASSCF/6-31G** calculations have been performed on the potential surface for the [3,3] sigmatropic allyl ester rearrangements of cis-3-penten-2-yl acetate (16) to trans-3-penten-2-yl acetate (17) and 3-buten-2-yl acetate (21) to trans-2-buten-1-yl acetate (22). The results are compared to DFT (B3LYP/6-31G**) calculations on the known 16→17 rearrangement that reported it to be concerted and pseudopericyclic through a boat-shaped transition structure (Birney, D. M. et al. J. Am. Chem...
January 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29350789/tcr-modifications-that-enhance-chain-pairing-in-gene-modified-t-cells-can-augment-cross-reactivity-and-alleviate-cd8-dependence
#8
Timothy T Spear, Kendra C Foley, Elizabeth Garrett-Mayer, Michael I Nishimura
T cell receptor (TCR) gene-modified T cells are a promising immunotherapy but require refinement to improve clinical responses and limit off-target toxicities. A variety of TCR and gene-delivery vector modifications have been developed to enhance introduced TCR expression and limit introduced/endogenous TCR chain mispairing, improving target antigen recognition and minimizing mispairing-induced cross-reactivity. Using our well-characterized HCV1406 TCR, we previously compared the impact of various chain pairing enhancing modifications on TCR expression and cognate antigen recognition...
January 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29350631/competition-and-coexistence-of-polar-and-non-polar-states-in-sr-sub-1-x-sub-ca-sub-x-sub-tio-sub-3-sub-an-investigation-using-pressure-dependent-raman-spectroscopy
#9
Shekhar Tyagi, Gaurav Sharma, Vasant G Sathe
The competition and cooperation between ferroelectric and antiferrodistortive (AFD) instabilities are studied using pressure dependent Raman spectroscopy on polycrystalline powder samples of Sr1-xCaxTiO3(x=0.0, 0.06, 0.25, 0.35). For x=0.0 composition, broad polar mode is detected in the Raman spectra above 6 GPa, while for x=0.06 composition the polar modes appear well above 9 GPa where the AFD modes showed strong suppression. In x=0.25 and 0.35 composition the application of small pressure results in appearance of strong AFD modes suppressing the polar modes...
January 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29350568/abp-980-promising-trastuzumab-biosimilar-for-her2-positive-breast-cancer
#10
Elisavet Paplomata, Rita Nahta
Approval of the HER2-targeted antibody trastuzumab dramatically improved outcomes for patients with HER2-positive breast cancer. Multiple trastuzumab biosimilars, including ABP 980, are in clinical development. Biosimilars are not identical to the reference biologic, but exhibit equivalence and safety in analytical and clinical studies. Areas covered: A brief introduction to trastuzumab, overview of trastuzumab biosimilars, and detailed review of ABP 980 preclinical and clinical studies are included. We searched PubMed and 2016-2017 ASCO and ESMO conference proceedings for "ABP 980" or "trastuzumab biosimilar"...
January 19, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29350439/tandem-mass-spectroscopy-as-a-tool-for-investigation-of-complexes-of-pnp-lariat-ether-derivative-with-metals-ions
#11
Natalia Gutowska, Piotr Seliger, Grzegorz Andrijewski, Grażyna Adamus, Iwona Kwiecień
The novel PNP-lariat ether L with cyclotriphosphazene ring incorporated in the macrocyclic structure was synthesized and checked by the ESI-MS method for the ability to bind different types of ions Ag+ , Ca2+ , Cd2+ , Cu2+ and Pb2+ . Furthermore, the stability constants of the abovementioned ions complexes with the investigated ligand have been determined by direct and competitive potentiometric methods. In order to evaluate the stability of various complexes types and to confirm the way of metal cation binding, the tandem mass spectra (MS/MS) of the investigated ligand and its complexes were taken...
January 19, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29349873/carbon-molecular-sieve-membranes-derived-from-tr%C3%A3-ger-s-base-based-microporous-polyimide-for-gas-separation
#12
Jian Jin, Zhenggong Wang, Huiting Ren, Shenxiang Zhang, Feng Zhang
Carbon molecular sieve (CMS) membrane based membrane attracts great attentions because of their outstanding gas separation performance. Polymer precursor is one of key points for preparation of high performance CMS. Tröger's base (TB) group is constructed by a bridged bicyclic amine. Such a bicyclic bridged stereo structure endows TB unit with highly contorted and great shape-persistent properties. In this work, a TB-based PIM-PI (TB-PI) is used as a polymer precursor to prepare CMS for the first time. By optimizing the thermal treatment condition, three CMS membranes treated under different soaking temperatures named TB-CMS-550, TB-CMS-650, and TB-CMS-800 were obtained...
January 19, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29349723/species-diversity-and-tissue-specific-dispersal-of-necrophagous-diptera-on-human-bodies
#13
Victoria Bernhardt, Miklós Bálint, Marcel A Verhoff, Jens Amendt
In forensic entomology, many studies analyze fly activity and succession on dead bodies by using pig cadavers and a variety of small baited traps. Data on real human bodies are very rare. To address this shortcoming, we analyzed the fly fauna of 51 human bodies in Germany. Sex, age, place of discovery, and presumed time of death were noted. Larvae were sampled during autopsy according to body region or tissue. For every infested region, the total number of fly larvae were estimated and classified into categories of 1-10, 11-50, and 50+...
January 18, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29349610/ligand-binding-dynamics-for-pre-dimerised-g-protein-coupled-receptor-homodimers-linear-models-and-analytical-solutions
#14
Carla White, Lloyd J Bridge
Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is therefore required as an addition to classical receptor theory, which is largely built on assumptions of monomeric receptors. A key factor in developing theoretical models of dimer signalling is cooperativity across the dimer, whereby binding of a ligand to one protomer affects the binding of a ligand to the other protomer...
January 18, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29349443/large-valley-polarization-in-monolayer-mote2-on-a-magnetic-substrate
#15
Ningbo Li, Jiayong Zhang, Yang Xue, Tong Zhou, Zhongqin Yang
On the basis of valley degree of freedom, there would be immense potential application in valleytronics. Introducing magnetism into triangular or hexagonal lattices is a promising route to realize valley polarization, which is indispensable for applying the valley degree of freedom. In this study, we explored valley polarization by depositing a heterostructure of a MoTe2 monolayer on the (0 0 1) surface of an antiferromagnetic RbMnCl3 substrate. First principles-calculations showed that due to proximity-induced Zeeman effects, the MoTe2 monolayer was drastically magnetized by the topmost Mn layer in the substrate and a very large valley splitting (about 109 meV) was achieved...
January 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29349095/spinal-motocross-injuries-in-the-united-kingdom
#16
Rohit Singh, Amit Bhalla, Matthew Ockendon, Stuart Hay
Background: Motocross is a form of motorcycle racing held on established off-road circuits and has been a recreational and competitive sport across the world for >100 years. In the United Kingdom alone, motocross has grown into a phenomenally ambitious and popular franchise. There are >200 motocross clubs across the country, permitting >900 events annually. Purpose: To assess the current trend of spine-related motocross injuries over the past 5 years. Study Design: Descriptive epidemiology study...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29349094/upper-extremity-functional-status-of-female-youth-softball-pitchers-using-the-kerlan-jobe-orthopaedic-clinic-questionnaire
#17
Kaila A Holtz, Russell J O'Connor
Background: Softball is a popular sport with a high incidence of upper extremity injuries. The Kerlan-Jobe Orthopaedic Clinic (KJOC) questionnaire is a validated performance and functional assessment tool used in overhead athletes. Upper extremity pain patterns and baseline KJOC scores have not been reported for active female youth softball pitchers. Purpose/Hypothesis: The purpose of this study was to establish the prevalence of upper extremity pain and its effect in female youth softball pitchers over a competitive season...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29348811/disconnecting-the-estrogen-receptor-binding-properties-and-antimicrobial-properties-of-parabens-through-3-5-substitution
#18
Bridget L Bergquist, Kaelyn G Jefferson, Hailey N Kintz, Amorette E Barber, Andrew A Yeagley
Commercially utilized parabens are employed for their antimicrobial properties, but a weak binding to the estrogen receptor alpha (ERα) may lead to breast cancer in some applications. Modification of the paraben scaffold should allow for a disconnection of these observed properties. Toward this goal, various 3,5-substituted parabens were synthesized and assessed for antimicrobial properties against S. aureus as well as competitive binding to the ERα. The minimum inhibitory concentration assay confirmed retention of antimicrobial activity in many of these derivatives, while all compounds exhibited decreased xenoestrogen activity as determined by a combination of competitive enzyme linked immunosorbent assay (ELISA), proliferation, and estrogen receptor binding assay...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348614/noise-induced-bistability-in-the-fate-of-cancer-phenotypic-quasispecies-a-bit-strings-approach
#19
Josep Sardanyés, Tomás Alarcón
Tumor cell populations are highly heterogeneous. Such heterogeneity, both at genotypic and phenotypic levels, is a key feature during tumorigenesis. How to investigate the impact of this heterogeneity in the dynamics of tumors cells becomes an important issue. Here we explore a stochastic model describing the competition dynamics between a pool of heterogeneous cancer cells with distinct phenotypes and healthy cells. This model is used to explore the role of demographic fluctuations on the transitions involving tumor clearance...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348554/effects-of-co2-enrichment-on-benthic-primary-production-and-inorganic-nitrogen-fluxes-in-two-coastal-sediments
#20
Kay Vopel, Cintya Del-Río, Conrad A Pilditch
Ocean acidification may alter the cycling of nitrogen in coastal sediment and so the sediment-seawater nitrogen flux, an important driver of pelagic productivity. To investigate how this perturbation affects the fluxes of NOX- (nitrite/nitrate), NH4+ and O2, we incubated estuarine sand and subtidal silt in recirculating seawater with a CO2-adjusted pH of 8.1 and 7.9. During a 41-day incubation, the seawater kept at pH 8.1 lost 97% of its NOX- content but the seawater kept at pH 7.9 lost only 18%. Excess CO2 increased benthic photosynthesis...
January 18, 2018: Scientific Reports
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