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https://www.readbyqxmd.com/read/28214288/an-accelerator-mass-spectrometry-enabled-microtracer-study-to-evaluate-the-first-pass-effect-on-the-absorption-of-yh4808
#1
Anhye Kim, Byung-Yong Yu, Stephen R Dueker, Kwang-Hee Shin, Hwa Suk Kim, Hyungmi Ahn, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang, Howard Lee
(14) C-labeled YH4808, a novel potassium-competitive acid blocker, was intravenously administered as a microtracer at 80 μg (11.8 kBq or 320 nCi) concomitantly with the non-radiolabeled oral drug at 200 mg to determine the absolute bioavailability and to assess the effect of pharmacogenomics on the oral absorption of YH4808. The absolute bioavailability was low and highly variable (mean, 10.1%; range, 2.3-19.3%), and M3 and M8, active metabolites of YH4808, were formed 22.6- and 38.5-fold higher after oral administration than intravenous administration, respectively...
February 18, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28213834/molecular-simulation-of-receptor-occupancy-and-tumor-penetration-of-an-antibody-and-smaller-scaffolds-application-to-molecular-imaging
#2
Kelly D Orcutt, Gregory P Adams, Anna M Wu, Matthew D Silva, Catey Harwell, Jack Hoppin, Manabu Matsumura, Masakatsu Kotsuma, Jonathan Greenberg, Andrew M Scott, Robert A Beckman
PURPOSE: Competitive radiolabeled antibody imaging can determine the unlabeled intact antibody dose that fully blocks target binding but may be confounded by heterogeneous tumor penetration. We evaluated the hypothesis that smaller radiolabeled constructs can be used to more accurately evaluate tumor expressed receptors. PROCEDURES: The Krogh cylinder distributed model, including bivalent binding and variable intervessel distances, simulated distribution of smaller constructs in the presence of increasing doses of labeled antibody forms...
February 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28213673/individual-placement-and-support-ips-for-methadone-maintenance-therapy-patients-a-pilot-randomized-controlled-trial
#3
Carrie E Lones, Gary R Bond, Mark P McGovern, Kathryn Carr, Teresa Leckron-Myers, Tim Hartnett, Deborah R Becker
Individual Placement and Support (IPS) is an evidence-based employment model for people with severe mental illness, but it has not been evaluated for clients enrolled in substance abuse treatment programs. This study evaluated the effectiveness of IPS for people with opioid use disorders enrolled in an opioid treatment program. Within a randomized controlled experiment, 45 patients receiving methadone maintenance therapy were assigned to either IPS or a 6-month waitlist. The waitlist group received IPS after 6 months...
February 17, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28213672/federal-policies-and-programs-to-expand-employment-services-among-individuals-with-serious-mental-illnesses
#4
Mustafa Karakus, Jarnee Riley, Howard Goldman
Previous studies suggest that providing employment services to individuals with serious mental illnesses can help them obtain competitive, real-world employment. However, these services are still not easily accessible to this population. This paper provides a brief summary of recent federal initiatives that may influence widespread implementation of employment services. While there is an increasing recognition of the need to remove barriers and provide supported employment services to individuals with mental illnesses, a wide-spread coordination across Federal polices, financing and regulatory changes are necessary to promote measurable and lasting effects on the broad availability of employment services among this population...
February 17, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28213538/colonization-and-transmission-of-the-gut-microbiota-of-the-burying-beetle-nicrophorus-vespilloides-through-development
#5
Yin Wang, Daniel E Rozen
Carrion beetles in the genus Nicrophorus rear their offspring on decomposing carcasses where larvae are exposed to a diverse community of decomposer bacteria. Parents coat the carcass with antimicrobial secretions prior to egg hatch (defined as Pre-Hatch care) and also feed regurgitated food, and potentially bacteria, to larvae throughout development (defined as Full care). Here we partition the roles of pre- and post-hatch parental care in the transmission and persistence of culturable symbiotic bacteria to larvae...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28213239/new-urea-modified-paper-substrate-for-enhanced-analytical-performance-of-negative-ion-mode-paper-spray-mass-spectrometry
#6
Jingjing Liu, Yan He, Shuo Chen, Ming Ma, Shouzuo Yao, Bo Chen
Electrospray ionization mass spectrometry (ESI-MS) analysis in the negative ion mode is adversely affected by ionization suppression caused by electrical discharge and the presence of salts. Paper spray mass spectrometry (PS-MS) also suffers from the above phenomenon, being built on principles similar to those of ESI. Herein, we report the use of a paper substrate modified by 1-[3-(trimethoxysilyl)propyl]urea to improve the sensitivity of quantitative PS-MS analysis in the negative ion mode. The obtained results demonstrated that the urea modified paper substrate can effectively bind anions and highly polar compounds in the sample solution, decreasing competitive ionization in the negative ion mode of PS-MS and significantly reducing the signal intensity of Cl(-) adducts...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213222/development-of-a-qcm-d-biosensor-for-ochratoxin-a-detection-in-red-wine
#7
Aleksandra Karczmarczyk, Karsten Haupt, Karl-Heinz Feller
Ochratoxin A (OTA), a highly toxic compound, is one of the most widely spread mycotoxins that contaminates a large variety of agricultural commodities. Due to its presence in the food chain, it imposes a hazard on both human and animal health. Therefore, there is a need for precise, fast and simple methods for toxin quantification. Herein, a novel sensor based on a quartz crystal microbalance with dissipation monitoring (QCM-D) and antibodies for specific analyte recognition was developed for rapid and sensitive detection of OTA in red wine...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212967/decision-making-on-medical-innovations-in-a-changing-health-care-environment-insights-from-accountable-care-organizations-and-payers-on-personalized-medicine-and-other-technologies
#8
Julia R Trosman, Christine B Weldon, Michael P Douglas, Patricia A Deverka, John B Watkins, Kathryn A Phillips
BACKGROUND: New payment and care organization approaches, such as those of accountable care organizations (ACOs), are reshaping accountability and shifting risk, as well as decision making, from payers to providers, within the Triple Aim context of health reform. The Triple Aim calls for improving experience of care, improving health of populations, and reducing health care costs. OBJECTIVES: To understand how the transition to the ACO model impacts decision making on adoption and use of innovative technologies in the era of accelerating scientific advancement of personalized medicine and other innovations...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212840/a-density-dependent-model-of-competition-for-one-resource-in-the-chemostat
#9
Radhouane Fekih-Salem, Claude Lobry, Tewfik Sari
This paper deals with a two-microbial species model in competition for a single-resource in the chemostat including general intra- and interspecific density-dependent growth rates with distinct removal rates for each species. In order to understand the effects of intra- and interspecific interference, this general model is first studied by determining the conditions of existence and local stability of steady states. With the same removal rate, the model can be reduced to a planar system and then the global stability results for each steady state are derived...
February 14, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28212624/understanding-the-response-to-endurance-exercise-using-a-systems-biology-approach-combining-blood-metabolomics-transcriptomics-and-mirnomics-in-horses
#10
Núria Mach, Yuliaxis Ramayo-Caldas, Allison Clark, Marco Moroldo, Céline Robert, Eric Barrey, Jesús Maria López, Laurence Le Moyec
BACKGROUND: Endurance exercise in horses requires adaptive processes involving physiological, biochemical, and cognitive-behavioral responses in an attempt to regain homeostasis. We hypothesized that the identification of the relationships between blood metabolome, transcriptome, and miRNome during endurance exercise in horses could provide significant insights into the molecular response to endurance exercise. For this reason, the serum metabolome and whole-blood transcriptome and miRNome data were obtained from ten horses before and after a 160 km endurance competition...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212584/hyaluronic-acid-serum-albumin-conjugate-based-nanoparticles-for-targeted-cancer-therapy
#11
Ravit Edelman, Yehuda G Assaraf, Inna Levitzky, Tal Shahar, Yoav D Livney
Multiple carcinomas including breast, ovarian, colon, lung and stomach cancer, overexpress the hyaluronic acid (HA) receptor, CD44. Overexpression of CD44 contributes to key cancer processes including tumor invasion, metastasis, recurrence, and chemoresistance. Herein, we devised novel targeted nanoparticles (NPs) for delivery of anticancer chemotherapeutics, comprised of self-assembling Maillard reaction-based conjugates of HA and bovine serum albumin (BSA). HA served as the hydrophilic block, and as the ligand for actively targeting cancer cells overexpressing CD44...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212513/simultaneous-removal-of-no-and-hg-0-over-ce-cu-modified-v2o5-tio2-based-commercial-scr-catalysts
#12
Guilong Chi, Boxiong Shen, Ranran Yu, Chuan He, Xiao Zhang
A series of novel Ce-Cu modified V2O5/TiO2 based commercial SCR catalysts were prepared via ultrasonic-assisted impregnation method for simultaneous removal of NO and elemental mercury (Hg(0)). Nitrogen adsorption, X-ray diffraction (XRD), temperature programmed reduction of H2 (H2-TPR) and X-ray photoelectron spectroscopy (XPS) were used to characterize the catalysts. 7% Ce-1% Cu/SCR catalyst exhibited the highest NO conversion efficiency (>97%) at 200-400°C, as well as the best Hg(0) oxidation activity (>75%) at 150-350°C among all the catalysts...
February 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28212502/a-new-mechanism-shapes-the-na%C3%A3-ve-cd8-t-cell-repertoire-the-selection-for-full-diversity
#13
Pedro Gonçalves, Marco Ferrarini, Carmen Molina-Paris, Grant Lythe, Florence Vasseur, Annik Lim, Benedita Rocha, Orly Azogui
During thymic T cell differentiation, TCR repertoires are shaped by negative, positive and agonist selection. In the thymus and in the periphery, repertoires are also shaped by strong inter-clonal and intra-clonal competition to survive death by neglect. Understanding the impact of these events on the T cell repertoire requires direct evaluation of TCR expression in peripheral naïve T cells. Several studies have evaluated TCR diversity, with contradictory results. Some of these studies had intrinsic technical limitations since they used material obtained from T cell pools, preventing the direct evaluation of clone sizes...
February 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28212440/emergent-inequality-and-self-organized-social-classes-in-a-network-of-power-and-frustration
#14
Benoit Mahault, Avadh Saxena, Cristiano Nisoli
We propose a simple agent-based model on a network to conceptualize the allocation of limited wealth among more abundant expectations at the interplay of power, frustration, and initiative. Concepts imported from the statistical physics of frustrated systems in and out of equilibrium allow us to compare subjective measures of frustration and satisfaction to collective measures of fairness in wealth distribution, such as the Lorenz curve and the Gini index. We find that a completely libertarian, law-of-the-jungle setting, where every agent can acquire wealth from or lose wealth to anybody else invariably leads to a complete polarization of the distribution of wealth vs...
2017: PloS One
https://www.readbyqxmd.com/read/28212426/sustainability-of-common-pool-resources
#15
Raja Rajendra Timilsina, Koji Kotani, Yoshio Kamijo
Sustainability has become a key issue in managing natural resources together with growing concerns for capitalism, environmental and resource problems. We hypothesize that the ongoing modernization of competitive societies, which we refer to as "capitalism," affects human nature for utilizing common pool resources, thus compromising sustainability. To test this hypothesis, we design and implement a set of dynamic common pool resource games and experiments in the following two types of Nepalese areas: (i) rural (non-capitalistic) and (ii) urban (capitalistic) areas...
2017: PloS One
https://www.readbyqxmd.com/read/28212322/detection-of-salmonella-typhimurium-on-spinach-using-phage-based-magnetoelastic-biosensors
#16
Fengen Wang, Shin Horikawa, Jiajia Hu, Howard C Wikle, I-Hsuan Chen, Songtao Du, Yuzhe Liu, Bryan A Chin
Phage-based magnetoelastic (ME) biosensors have been studied as an in-situ, real-time, wireless, direct detection method of foodborne pathogens in recent years. This paper investigates an ME biosensor method for the detection of Salmonella Typhimurium on fresh spinach leaves. A procedure to obtain a concentrated suspension of Salmonella from contaminated spinach leaves is described that is based on methods outlined in the U.S. FDA Bacteriological Analytical Manual for the detection of Salmonella on leafy green vegetables...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212282/collagen-gold-nanoparticle-conjugates-for-versatile-biosensing
#17
Sarah Unser, Samuel Holcomb, ReJeana Cary, Laura Sagle
Integration of noble metal nanoparticles with proteins offers promising potential to create a wide variety of biosensors that possess both improved selectivity and versatility. The multitude of functionalities that proteins offer coupled with the unique optical properties of noble metal nanoparticles can allow for the realization of simple, colorimetric sensors for a significantly larger range of targets. Herein, we integrate the structural protein collagen with 10 nm gold nanoparticles to develop a protein-nanoparticle conjugate which possess the functionality of the protein with the desired colorimetric properties of the nanoparticles...
February 15, 2017: Sensors
https://www.readbyqxmd.com/read/28212170/predictors-of-acquisition-of-competitive-employment-for-people-enrolled-in-supported-employment-programs
#18
Marc Corbière, Tania Lecomte, Daniel Reinharz, Bonnie Kirsh, Paula Goering, Matthew Menear, Djamal Berbiche, Karine Genest, Elliot M Goldner
This study aims at assessing the relative contribution of employment specialist competencies working in supported employment (SE) programs and client variables in determining the likelihood of obtaining competitive employment. A total of 489 persons with a severe mental illness and 97 employment specialists working in 24 SE programs across three Canadian provinces were included in the study. Overall, 43% of the sample obtained competitive work. Both client variables and employment specialist competencies, while controlling for the quality of SE programs implementation, predicted job acquisition...
February 16, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28212104/joint-feature-selection-and-classification-for-multilabel-learning
#19
Jun Huang, Guorong Li, Qingming Huang, Xindong Wu
Multilabel learning deals with examples having multiple class labels simultaneously. It has been applied to a variety of applications, such as text categorization and image annotation. A large number of algorithms have been proposed for multilabel learning, most of which concentrate on multilabel classification problems and only a few of them are feature selection algorithms. Current multilabel classification models are mainly built on a single data representation composed of all the features which are shared by all the class labels...
February 14, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28211714/6%C3%AF-josephson-effect-in-majorana-box-devices
#20
A Zazunov, F Buccheri, P Sodano, R Egger
We study Majorana devices featuring a competition between superconductivity and multichannel Kondo physics. Our proposal extends previous work on single-channel Kondo systems to a topologically nontrivial setting of a non-Fermi liquid type, where topological superconductor wires (with gap Δ) represent leads tunnel coupled to a Coulomb-blockaded Majorana box. On the box, a spin degree of freedom with Kondo temperature T_{K} is nonlocally defined in terms of Majorana states. For Δ≫T_{K}, the destruction of Kondo screening by superconductivity implies a 4π-periodic Josephson current-phase relation...
February 3, 2017: Physical Review Letters
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