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https://www.readbyqxmd.com/read/28528723/ventricular-pacing-in-single-ventricles-a-bad-combination
#1
Anica Bulic, Frank J Zimmerman, Scott R Ceresnak, Ira Shetty, Kara S Motonaga, Anne Freter, Anthony V Trela, Deb Hanisch, Lisa Russo, Kishor Avasarala, Anne M Dubin
BACKGROUND: Chronic ventricular pacing (VP) is associated with systolic dysfunction in a subset of pediatric patients with heart block and structurally normal hearts. The effect of chronic VP in congenital heart disease is less well understood, specifically in the single-ventricle (SV) population. OBJECTIVE: To determine the longitudinal effect of VP in SV patients. METHODS: SV patients with heart block and dual-chamber pacemakers requiring >50% VP were compared with nonpaced (controls) SV patients matched for age, sex, and SV morphology...
June 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28524082/cellular-repair-of-dna-dna-cross-links-induced-by-1-2-3-4-diepoxybutane
#2
Lisa N Chesner, Amanda Degner, Dewakar Sangaraju, Shira Yomtoubian, Susith Wickramaratne, Bhaskar Malayappan, Natalia Tretyakova, Colin Campbell
Xenobiotic-induced interstrand DNA-DNA cross-links (ICL) interfere with transcription and replication and can be converted to toxic DNA double strand breaks. In this work, we investigated cellular responses to 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) cross-links induced by 1,2,3,4-diepoxybutane (DEB). High pressure liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI⁺-MS/MS) assays were used to quantify the formation and repair of bis-N7G-BD cross-links in wild-type Chinese hamster lung fibroblasts (V79) and the corresponding isogenic clones V-H1 and V-H4, deficient in the XPD and FANCA genes, respectively...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28523885/intraepidermal-type-vii-collagen-by-immunofluorescence-mapping-a-specific-finding-for-bullous-dermolysis-of-the-newborn
#3
Gillian Heinecke, M Peter Marinkovich, Kerri E Rieger
BACKGROUND: Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa (DEB) characterized by skin fragility and blister formation at birth that typically resolves within the first year of life. Abnormal intraepidermal retention of type VII collagen (C7) has been reported as a characteristic feature of BDN, but few studies have investigated the specificity of this finding. METHODS: We retrospectively reviewed pathology reports of patients diagnosed with DEB using immunofluorescence mapping from January 2001 to January 2015...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28523715/dual-en-bloc-technique-for-adult-renal-transplantation
#4
Kim Chi Tran, David Li, Ali Taqi, Alp Sener, Vivian C McAlister, Patrick P Luke
INTRODUCTION: We describe and provide follow-up for a novel simplified technique permitting dual en-bloc (DEB) transplantation of adult organs using single in situ arterial and venous anastomoses. METHODS: Twenty-two adult DEB transplants were performed at our centre between 2001 and 2012, utilizing 44 kidneys en bloc. Results were compared with 20 solitary transplants from expanded criteria donors (ECD) associated with lower terminal serum creatinines and Remuzzi biopsy scores vs...
May 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28521735/exercise-and-eating-habits-among-urban-adolescents-a-cross-sectional-study-in-kolkata-india
#5
Soumitra Kumar, Saumitra Ray, Debabrata Roy, Kajal Ganguly, Sibananda Dutta, Tanmay Mahapatra, Sanchita Mahapatra, Kinnori Gupta, Kaushik Chakraborty, Mrinal Kanti Das, Santanu Guha, Pradip K Deb, Amal K Banerjee
BACKGROUND: Unhealthy eating and lack of exercise during adolescence culminated into earlier onset and increasing burden of atherosclerotic cardiovascular diseases (CVDs) worldwide. Among urban Indian adolescents, prevalence of these risk factors of CVD seemed to be high, but data regarding their pattern and predictors was limited. To address this dearth of information, a survey was conducted among urban adolescent school-students in Kolkata, a highly populated metro city in eastern India...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28511364/comparative-study-on-insall-salvati-index-by-radiological-and-clinical-methods-in-a-tertiary-care-centre-of-north-bengal-india
#6
Maitreyee Kar, Dipankar Bhaumik, Samar Deb, Kaushik Ishore, Chinmaya Kar
INTRODUCTION: Patellar height is an important parameter of patellar stability. Its importance is evident from various attempts to measure it, by different scientists from time to time and many indices have been derived among which Insall-Salvati index (IS index) is the most simple, accurate and easy to measure. In this study a new clinical method has been tried to measure patellar height by applying the same principle of IS index. AIM: To compare clinical method of measurement of IS index with the one derived radiologically and to establish the higher cut off value of the clinical method...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28500458/occurrence-of-vascular-lake-phenomenon-as-a-predictor-of-improved-tumor-response-in-hcc-patients-that-underwent-deb-tace
#7
Rafael Noronha Cavalcante, Felipe Nasser, Joaquim M Motta-Leal-Filho, Breno B Affonso, Francisco L Galastri, Bruna De Fina, Rodrigo G Garcia, Nelson Wolosker
PURPOSE: To evaluate incidence and predictive factors for the vascular lake phenomenon (VLP), as well as to compare local and overall tumor response in patients with and without VLP induced during DEB-TACE for HCC. METHODS: A total of 200 consecutive patients with 323 HCC nodules underwent first-session DEB-TACE from 2011 to 2014. Patients were divided in two groups, according to the presence of the VLP during DEB-TACE. Pre- and post-treatment imaging studies (CT or MRI) were performed...
May 12, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28494806/what-makes-weekend-allied-health-services-effective-and-cost-effective-or-not-in-acute-medical-and-surgical-wards-perceptions-of-medical-nursing-and-allied-health-workers
#8
Lisa O'Brien, Deb Mitchell, Elizabeth H Skinner, Romi Haas, Marcelle Ghaly, Fiona McDermott, Kerry May, Terry Haines
BACKGROUND: There is strong public support for acute hospital services to move to genuine 7-day models, including access to multidisciplinary team assessment. This study aimed to identify factors that might enable an effective and cost-effective weekend allied health services on acute hospital wards. METHODS: This qualitative study included 22 focus groups within acute wards with a weekend allied health service and 11 telephone interviews with weekend service providers...
May 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28490526/atp-citrate-lyase-is-essential-for-high-glucose-induced-histone-hyperacetylation-and-fibrogenic-gene-up-regulation-in-mesangial-cells
#9
Dilip K Deb, Yinyin Chen, Jian Sun, Youli Wang, Yan Chun Li
TThe goal of this study was to address the role of ATP-citrate lyase (ACL), an enzyme that converts citrate to acetyl-CoA, in high glucose (HG)-induced histone acetylation and pro-fibrotic gene expression. Our recent ChIP-Seq studies have demonstrated that HG induces genome-wide histone hyperacetylation in mesangial cells (MCs). Here we showed that exposure of MCs to HG markedly increased histone acetylation at the H3K9/14 and H3K18 marks and induced the expression of potent pro-fibrotic factors TGF-β1, TGF-β3 and CTGF...
May 10, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28485747/granular-topological-insulators
#10
Abhishek Banerjee, Oindrila Deb, Kunjalata Majhi, R Ganesan, Diptiman Sen, P S Anil Kumar
We demonstrate experimentally that a macroscopic topological insulator (TI) phase can emerge in a granular conductor composed of an assembly of tunnel coupled TI nanocrystals of dimension ∼10 nm × 10 nm × 2 nm. Electrical transport measurements on thin films of Bi2Se3 nanocrystals reveal the presence of decoupled top and bottom topological surface states that exhibit large surface state penetration depths (∼30 nm at 2 K). By tuning the size of the nanocrystals and the couplings between them, this new class of TIs may be readily tuned from a non-topological to a topological insulator phase, that too with designer properties...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28484543/a-rare-case-of-recurrence-of-primary-spinal-neurocysticercosis-mimicking-an-arachnoid-cyst
#11
Anirban Pal, Chaitali Biswas, Tirtha R Ghosh, Pulak Deb
Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system but isolated primary spinal NCC is of very rare occurrence. The authors report a case of 44-year-old male, a postoperative case of multiple spinal NCC lesion excision 2 years ago, who presented with cauda equina syndrome and magnetic resonance imaging revealed a lesion mimicking an arachnoid cyst in the D1-9 region of the spinal cord. On intraoperative surgical exposure multiple cysts were found and excised. The suspicion of recurrence of NCC was confirmed by histopathology...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28480650/comparison-of-drug-eluting-balloon-followed-by-bare-metal-stent-with-drug-eluting-stent-for-treatment-of-de-novo-lesions-randomized-controlled-single-center-clinical-trial
#12
In Ho Chae, Chang Hwan Yoon, Jin Joo Park, Il Young Oh, Jung Won Suh, Young Seok Cho, Tae Jin Youn, Dong Ju Choi
The combined use of a drug-eluting balloon (DEB) and a bare metal stent (BMS) for the treatment of de novo non-small vessel coronary artery diseases (CAD) remains to be evaluated. We investigated the efficacy of a sequential treatment using a DEB together with a BMS implantation in comparison to a zotarolimus-eluting stent (ZES). This study was a prospective, randomized, open-label study. We designed it to demonstrate the non-inferiority of a sequential treatment using a DEB first followed by a BMS (DEB + BMS) compared with the use of a ZES...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28480062/locoregional-and-systemic-therapy-for-hepatocellular-carcinoma
#13
REVIEW
Olumide B Gbolahan, Michael A Schacht, Eric W Beckley, Thomas P LaRoche, Bert H O'Neil, Maximilian Pyko
The management of hepatocellular carcinoma (HCC) remains challenging due to late presentation and the presence of accompanying liver dysfunction. As such, most patients are not eligible for curative resection and liver transplant. Management in this scenario depends on a number of factors including hepatic function, tumor burden, patency of hepatic vasculature and patients' functional status. Based on these, patients can be offered catheter based intra-arterial therapy for intermediate stage disease and in more advanced disease, sorafenib...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28477016/e6ap-promotes-prostate-cancer-by-reducing-p27-expression
#14
Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt
Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously linked to PC, consistent with increased protein expression in a subset of PC patients. In cancers, irregular E3 ligase activity drives proteasomal degradation of tumor suppressor proteins. Accordingly, E3 ligase inhibitors define a rational therapy to restore tumor suppression. The relevant tumor suppressors targeted by E6AP in PC are yet to be fully identified. In this study we show that p27, a key cell cycle regulator, is a target of E6AP in PC...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474321/three-year-follow-up-of-laparoscopic-reduced-port-sleeve-gastrectomy-in-808-consecutive-patients
#15
Mohammad Al Jarallah, Radwan Kassir, Mohab El-Barbari, Shaaban Ali, Tarek Debs, Elie Chouillard
BACKGROUND: Sleeve gastrectomy (SG) is a very popular technique for the treatment of morbid obesity. Less and less invasive laparoscopic approaches to SG have been proposed and shown to be safe and feasible. OBJECTIVES: We developed a reduced port laparoscopic approach to sleeve gastrectomy (RLSG) with the aim to further optimize the advantages of laparoscopy. Preliminary and safety profile of RLSG as well as 3 years weight loss outcome are hereby discussed. SETTING: University Hospital, Kuwait...
May 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28474209/climatic-induced-shifts-in-the-distribution-of-teak-tectona-grandis-in-tropical-asia-implications-for-forest-management-and-planning
#16
Jiban Chandra Deb, Stuart Phinn, Nathalie Butt, Clive A McAlpine
Modelling the future suitable climate space for tree species has become a widely used tool for forest management planning under global climate change. Teak (Tectona grandis) is one of the most valuable tropical hardwood species in the international timber market, and natural teak forests are distributed from India through Myanmar, Laos and Thailand. The extents of teak forests are shrinking due to deforestation and the local impacts of global climate change. However, the direct impacts of climate changes on the continental-scale distributions of native and non-native teak have not been examined...
May 4, 2017: Environmental Management
https://www.readbyqxmd.com/read/28463641/exogenous-mir-29b-delivery-via-a-hyaluronan-based-injectable-system-yields-functional-maintenance-of-the-infarcted-myocardium
#17
Michael Monaghan, Monika Holeiter, Eva Brauchle, Shannon Layland, Yan Lu, Arjun Deb, Abhay Pandit, Ali Nsair, Katja Schenke-Layland
Myocardial infarction results in debilitating remodeling of the myocardial extracellular matrix. In this proof-of-principle study it was sought to modulate this aggressive remodeling by injecting a hyaluronic acid-based reservoir delivering exogenous microRNA-29B (miR-29B). This proof-of-principal study was executed whereby myocardial ischemia/reperfusion was performed on C57BL/6 mice for 45 minutes after which five 10 µl boluses of a hydrogel composed of thiolated hyaluronic acid crosslinked with poly (ethylene glycol) diacrylate, containing exogenous miR-29B as an active therapy, were injected into the borderzone of the infarcted myocardium...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28463520/regional-responses-to-the-challenge-of-delivering-integrated-care-to-older-people-with-mental-health-problems-in-rural-australia
#18
Julie Henderson, Suzanne Dawson, Jeffrey Fuller, Deb O'Kane, Adam Gerace, Candice Oster, Eimear Muir Cochrane
OBJECTIVE: Integrated care has been identified as means of managing the demands on the healthcare budget while improving access to and quality of services. It is particularly pertinent to rural health services, which face limited access to specialist and support services. This paper explores the capacity of three rural communities in South Australia to deliver integrated mental health support for older people. METHODS: Thirty-one interviews were conducted with local health and social service providers from mental health, community health, general practice, residential aged care, private practice, NGOs and local government as part of a larger action research project on service integration...
May 2, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28458470/intrinsic-properties-of-brown-and-white-adipocytes-have-differential-effects-on-macrophage-inflammatory-responses
#19
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of UCP-1, PGC1α, PGC1β, and CIDEA and their level of IL-6 secretion. The inflammatory profile of PMA-differentiated U937 and THP-1 macrophages, in resting state and after stimulation with LPS/IFN-gamma and IL-4, was assessed by measuring IL-6 secretion and transcriptional regulation of a panel of inflammatory genes after mono- or indirect coculture with white and brown adipocytes...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28457208/the-choice-project-peer-workers-promoting-shared-decision-making-at-a-youth-mental-health-service
#20
Magenta Bender Simmons, Samantha Batchelor, Tara Dimopoulos-Bick, Deb Howe
OBJECTIVE: In youth mental health services, consumer participation is essential, but few implementation strategies exist to engage young consumers. This project evaluated an intervention implemented in an Australian youth mental health service that utilized peer workers to promote shared decision making via an online tool. METHODS: All new clients ages 16-25 were invited to participate in this nonrandomized comparative study, which used a historical comparison group (N=80)...
May 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
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