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https://www.readbyqxmd.com/read/28087551/cost-effectiveness-of-superficial-femoral-artery-endovascular-interventions-in-the-uk-and-germany-a-modelling-study
#1
Benjamin C Kearns, Steven M Thomas
OBJECTIVES: To assess the lifetime costs and cost-effectiveness of 5 endovascular interventions to treat superficial femoral arterial disease. DESIGN: A model-based health economic evaluation. An existing decision analytical model was used, with updated effectiveness data taken from the literature, and updated costs based on purchasing prices. SETTING: UK and German healthcare perspectives were considered. PARTICIPANTS: Patients with intermittent claudication of the femoropopliteal arteries eligible for endovascular treatment...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28073058/surface-engineering-of-pamam-sdb-chelating-resin-with-diglycolamic-acid-dga-functional-group-for-efficient-sorption-of-u-vi-and-th-iv-from-aqueous-medium
#2
P Ilaiyaraja, A K Singha Deb, D Ponraju, Sk Musharaf Ali, B Venkatraman
A novel chelating resin obtained via growth of PAMAM dendron on surface of styrene divinyl benzene resin beads, followed by diglycolamic acid functionalization of the dendrimer terminal. Batch experiments were conducted to study the effects of pH, nitric acid concentration, amount of adsorbent, shaking time, initial metal ion concentration and temperature on U(VI) and Th(IV) adsorption efficiency. Diglycolamic acid terminated PAMAM dendrimer functionalized styrene divinylbenzene chelating resin (DGA-PAMAM-SDB) is found to be an efficient candidate for the removal of U(VI) and Th(IV) ions from aqueous (pH >4) and nitric acid media (>3M)...
January 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28068087/design-of-a-biased-potent-small-molecule-inhibitor-of-the-bromodomain-and-phd-finger-containing-brpf-proteins-suitable-for-cellular-and-in-vivo-studies
#3
Niall Igoe, Elliott D Bayle, Oleg Fedorov, Cynthia Tallant, Pavel Savitsky, Catherine Rogers, Dafydd R Owen, Gauri Deb, Tim C P Somervaille, David M Andrews, Neil Jones, Anne Cheasty, Hamish Ryder, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish
The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although there is an emerging understanding of a role in acute myeloid leukemia (AML). We report the optimization of fragment hit 5b to 13-d as a biased, potent inhibitor of the BRD of the BRPFs with excellent selectivity over nonclass IV BRD proteins. Evaluation of 13-d in a panel of cancer cell lines showed a selective inhibition of proliferation of a subset of AML lines...
January 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28067488/building-a-wall-on-the-imaginary-line
#4
Deb Niemeier
No abstract text is available yet for this article.
January 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28061015/impact-of-vessel-wall-lesions-and-vascular-stenoses-on-cerebrovascular-reactivity-in-patients-with-intracranial-stenotic-disease
#5
Petrice M Cogswell, Taylor L Davis, Megan K Strother, Carlos C Faraco, Allison O Scott, Lori C Jordan, Matthew R Fusco, Blaise deB Frederick, Jeroen Hendrikse, Manus J Donahue
PURPOSE: To compare cerebrovascular reactivity (CVR) and CVR lagtimes in flow territories perfused by vessels with vs. without proximal arterial wall disease and/or stenosis, separately in patients with atherosclerotic and nonatherosclerotic (moyamoya) intracranial stenosis. MATERIALS AND METHODS: Atherosclerotic and moyamoya patients with >50% intracranial stenosis and <70% cervical stenosis underwent angiography, vessel wall imaging (VWI), and CVR-weighted imaging (n = 36; vessel segments evaluated = 396)...
January 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28058433/theoretical-investigation-of-gas-phase-molecular-complex-formation-between-2-hydroxy-thiophenol-and-a-water-molecule
#6
Debojit Kumar Deb, Biplab Sarkar
The torsional potential of OH and SH rotations in 2-hydroxy thiophenol is systematically studied using the MP2 ab initio method. The outcome of state-of-the-art calculations is used in the investigation of the structures and conformational preferences of 2-hydroxy thiophenol and aims at further interaction studies with a gas phase water molecule. SCS-MP2 and CCSD(T) complete basis set (CBS) limit interaction energies for these complexes are presented. The SCS-MP2/CBS limit is achieved using various two-point extrapolation methods with aug-cc-pVDZ and aug-cc-pVTZ basis sets...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28056352/painful-perineal-mass-what-is-the-diagnosis
#7
Niccolo' Petrucciani, Tarek Debs, Jean Gugenheim
No abstract text is available yet for this article.
January 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28047935/su-f-t-263-dosimetric-characteristics-of-the-cine-acquisition-mode-of-an-a-si-epid
#8
O Bawazeer, S Sarasanandarajah, S Herath, T Kron, P Deb
PURPOSE: To investigate the dosimetric characteristics of Varian a-Si-500 electronic portal imaging device (EPID) operated in cine mode particularly considering linearity with delivered dose, dose rate, field size, phantom thickness, MLC speed and common IMRT fields. METHODS: The EPID that attached to a Varian Clinac 21iX linear accelerator, was irradiated with 6 and 18 MV using 600 MU/min. Image acquisition is controlled by the IAS3 software, Trigger delay was 6 ms, BeamOnDelay and FrameStartDelay were zero...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046897/we-h-brc-04-implement-lean-methodology-to-make-our-current-process-of-ct-simulation-to-treatment-more-efficient
#9
S Boddu, A Morrow, N Krishnamurthy, A McVicker, N Deb, D Rangaraj
PURPOSE: Our goal is to implement lean methodology to make our current process of CT simulation to treatment more efficient. METHODS: In this study, we implemented lean methodology and tools and employed flowchart in excel for process-mapping. We formed a group of physicians, physicists, dosimetrists, therapists and a clinical physics assistant and huddled bi-weekly to map current value streams. We performed GEMBA walks and observed current processes from scheduling patient CT Simulations to treatment plan approval...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043660/comparison-of-outcomes-after-treatment-of-in-stent-restenosis-using-newer-generation-drug-eluting-stents-versus-drug-eluting-balloon-patient-level-pooled-analysis-of-korean-multicenter-in-stent-restenosis-registry
#10
Joo Myung Lee, Tae-Min Rhee, Joo-Yong Hahn, Doyeon Hwang, Jonghanne Park, Kyung Woo Park, Hack-Lyoung Kim, Sang-Hyun Kim, In-Ho Chae, Joon-Hyung Doh, Ki-Hyun Jeon, Young Jin Choi, Jin Sik Park, Seung-Hyuck Choi, Hyeon-Cheol Gwon, Bon-Kwon Koo, Fernando Alfonso, Hyo-Soo Kim
BACKGROUND: Studies comparing the drug-eluting balloon (DEB) with contemporary drug-eluting stent (DES) in the treatment of in-stent restenosis (ISR) have been scarce. We compared that the efficacy and safety of contemporary DES versus DEB in unselected, real world patients of ISR occurred in bare-metal stent or DES. METHODS: Patient-level pooled analysis from nationwide multicenter registries was performed with 628 consecutive patients who underwent ISR treatment using 2nd or 3rd generation DES or DEB...
December 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28041743/iatrogenic-venous-air-embolism-from-central-venous-catheterization-after-blunt-liver-trauma
#11
Tarek Debs, Niccolo Petrucciani, Eric Sejor, Imed Ben Amor, Jean Gugenheim
No abstract text is available yet for this article.
December 29, 2016: Surgery
https://www.readbyqxmd.com/read/28028342/kimura-s-disease-a-diagnostic-challenge-experienced-with-cytology-of-postauricular-swelling-with-histopathological-relevance
#12
Mingma Sherpa, Rachna Lamichaney, Asitava Deb Roy
Kimura's disease is a rare, chronic inflammatory disorder of unknown cause. It is endemic in Asia, affecting more number of males than females, with a ratio of 3:1. The typical clinical manifestations include a triad of painless unilateral cervical lymphadenopathy or subcutaneous masses predominantly in the head and neck region, blood and tissue eosinophilia, and an elevated serum immunoglobulin E (IgE) levels. Variable conditions both benign and malignant may mimic Kimura's disease both clinically and on fine needle aspirates...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28024604/direct-one-pot-synthesis-of-glutathione-capped-hydrophilic-fept-cds-nanoprobe-for-efficient-bimodal-imaging-application
#13
Deepak K Jha, Koushik Saikia, Srijita Chakrabarti, Kakoli Bhattacharya, Komanduri S Varadarajan, Anant B Patel, Danswrang Goyary, P Chattopadhyay, P Deb
One-pot synthesis methods for development of hydrophilic imaging nanoprobes have advantages over multi-pot methods due to their simple procedures, less probability for degradation of efficiency, superior control over growth and morphology, cost effectiveness, improved scope for scale-up synthesis etc. Here, we present a novel one-pot facile synthesis of hydrophilic colloidal bimodal nanoprobe (FePt-CdS) prepared through a seed-mediated nucleation and growth technique. In this facile synthesis of complex nanostructure, glutathione (GSH) was used as the capping agent to render biocompatibility and dispersibility...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28019705/empathic-processes-during-nurse-consumer-conflict-situations-in-psychiatric-inpatient-units-a-qualitative-study
#14
Adam Gerace, Candice Oster, Deb O'Kane, Carly L Hayman, Eimear Muir-Cochrane
Empathy is a central component of nurse-consumer relationships. In the present study, we investigated how empathy is developed and maintained when there is conflict between nurses and consumers, and the ways in which empathy can be used to achieve positive outcomes. Through semistructured interviews, mental health nurses (n = 13) and consumers in recovery (n = 7) reflected on a specific conflict situation where they had experienced empathy, as well as how empathy contributed more generally to working with nurses/consumers...
December 26, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28018901/regulation-of-store-operated-ca-2-entry-by-septins
#15
Bipan K Deb, Gaiti Hasan
The mechanism of store-operated Ca(2+) entry (SOCE) brings extracellular Ca(2+) into cells after depletion of intracellular Ca(2+) stores. Regulation of Ca(2+) homeostasis by SOCE helps control various intracellular signaling functions in both non-excitable and excitable cells. Whereas essential components of the SOCE pathway are well characterized, molecular mechanisms underlying regulation of this pathway need investigation. A class of proteins recently demonstrated as regulating SOCE is septins. These are filament-forming GTPases that assemble into higher order structures...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28011243/comparison-of-paclitaxel-drug-eluting-balloon-and-paclitaxel-eluting-stent-in-small-coronary-vessels-in-diabetic-and-nondiabetic-patients-results-from-the-bello-balloon-elution-and-late-loss-optimization-trial
#16
Francesco Giannini, Azeem Latib, Richard J Jabbour, Charis Costopoulos, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Alberto Menozzi, Fausto Castriota, Antonio Micari, Alberto Cremonesi, Francesco De Felice, Alfredo Marchese, Maurizio Tespili, Patrizia Presbitero, Gregory A Sgueglia, Francesca Buffoli, Corrado Tamburino, Ferdinando Varbella, Antonio Colombo
OBJECTIVES: To evaluate the impact of diabetes on the efficacy of drug-eluting balloon (DEB) as compared to paclitaxel-eluting stent (PES) for the reduction of restenosis in small vessels according to the presence of diabetes in patients enrolled in the BELLO (Balloon Elution and Late Loss Optimization) trial. BACKGROUND: Small vessel disease is common in diabetic patients but currently there are no available data regarding DEB in these patients. METHODS: In the BELLO trial, 182 patients with lesions in small vessels were randomized 1:1 to receive DEB or PES...
December 15, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28003734/debs-a-unification-theory-for-dry-eye-and-blepharitis
#17
James M Rynerson, Henry D Perry
For many years, blepharitis and dry eye disease have been thought to be two distinct diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we propose a new way of looking at dry eye, both evaporative and insufficiency, as the natural sequelae of decades of chronic blepharitis. Dry eye is simply the late form and late manifestation of one disease, blepharitis. We suggest the use of a new term in describing this one chronic disease, namely dry eye blepharitis syndrome (DEBS)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28002084/use-of-visual-inspection-with-acetic-acid-pap-smear-or-high-risk-human-papillomavirus-testing-in-women-living-with-hiv-aids-for-posttreatment-cervical-cancer-screening-same-tests-different-priorities
#18
Elkanah Omenge Orang'o, Tao Liu, Astrid Christoffersen-Deb, Peter Itsura, John Oguda, Sierra Washington, David Chumba, Latha Pisharodi, Susan Cu-Uvin, Anne F Rositch
OBJECTIVES: Few studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect posttreatment cervical disease in HIV-infected women in Kenya. DESIGN: This is a prospective cohort study. METHODS: At least 6 months following cryotherapy, 517 HIV-infected women were evaluated concurrently with visual inspection with acetic acid (VIA), papanicolaou (Pap) smear, and high-risk human papillomavirus (HR-HPV) testing...
January 14, 2017: AIDS
https://www.readbyqxmd.com/read/28001261/evidences-of-autologous-fat-grafting-for-the-treatment-of-keloids-and-hypertrophic-scars
#19
Vinícius Zolezi DA Silva, Antonio Albacete, Grazielle DE Souza Horácio, Guilherme Augusto Magalhães DE Andrade, Leandro Debs Procópio, Pedro Soler Coltro, Jayme Adriano Farina
Introduction: Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature...
December 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27999336/debouganin-diabody-fusion-protein-overcomes-drug-resistance-to-adcs-comprised-of-anti-microtubule-agents
#20
Shilpa Chooniedass, Rachelle L Dillon, Arjune Premsukh, Peter J Hudson, Gregory P Adams, Glen C MacDonald, Jeannick Cizeau
Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class of therapeutic agents. The targeting of cytotoxic payloads via the specificity and selectivity of the antibody has led to substantial clinical benefits. However, ADC potency can be altered by mechanisms of resistance such as overexpression of efflux pumps or anti-apoptotic proteins. DeBouganin is a de-immunized variant of bouganin, a ribosome-inactivating protein (RIP) that blocks protein synthesis, thereby leading to apoptosis...
December 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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