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https://www.readbyqxmd.com/read/29777484/identification-of-differentially-expressed-micrornas-in-sahiwal-bos-indicus-breed-of-cattle-during-thermal-stress
#1
Gyanendra Singh Sengar, Rajib Deb, Umesh Singh, Vivek Junghare, Saugata Hazra, T V Raja, Rani Alex, Ashish Kumar, R R Alyethodi, Rajiv Kant, Subhash Jakshara, C G Joshi
microRNAs (miRNAs) are a class of small non-coding RNAs that play key roles in post transcriptional gene regulation that influence various fundamental cellular processes, including the cellular responses during environmental stresses. However, perusal of literatures revealed few reports on the differential expression of miRNA during thermal stress in Indian native (Bos indicus) cattle breeds. The present investigation aimed to identify differentially expressed miRNAs during thermal stress in Sahiwal (Bos indicus) dairy cattle breed of India, adapted with tropical climate over a long period of time...
May 18, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29773220/nhs-breast-screening-multidisciplinary-working-group-guidelines-for-the-diagnosis-and-management-of-breast-lesions-of-uncertain-malignant-potential-on-core-biopsy-b3-lesions
#2
S E Pinder, A Shaaban, R Deb, A Desai, A Gandhi, A H S Lee, S Pain, L Wilkinson, N Sharma
Needle core biopsy is considered the histological diagnostic method of choice for screen-detected breast lesions. Although the majority are definitively diagnosed as normal, benign, or malignant, approximately 7% are categorised as B3, of uncertain malignant potential. These include a wide range of lesions with different risks of associated malignancy from <2% to approaching 40% from literature review in UK practice. Historically, these have typically been surgically excised as a diagnostic procedure but the majority are then proven to be benign...
May 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29773151/changes-in-body-image-and-onset-of-disordered-eating-behaviors-in-youth-with-type-1-diabetes-over-a-five-year-longitudinal-follow-up
#3
Alda Troncone, Crescenzo Cascella, Antonietta Chianese, Ilaria Galiero, Angela Zanfardino, Santino Confetto, Laura Perrone, Dario Iafusco
OBJECTIVE: To examine changes over a five-year period in body image accuracy and dissatisfaction, as well as relationships with disordered eating behaviors (DEBs), in young patients with type 1 diabetes. METHODS: Of 81 children (42 male, 39 female) with type 1 diabetes first assessed at ages 5.1-10.06 years, 67 (83%) were re-enrolled and interviewed as adolescents (aged 10.07-15.08 years) at follow-up. DEBs were assessed using a parent-report standardized measure...
June 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29765513/20-s-protopanaxadiol-regio-selectively-targets-androgen-receptor-anticancer-effects-in-castration-resistant-prostate-tumors
#4
Mohamed Ben-Eltriki, Subrata Deb, Mohamed Hassona, Gray Meckling, Ladan Fazli, Mei Yieng Chin, Nada Lallous, Takeshi Yamazaki, William Jia, Paul S Rennie, Artem Cherkasov, Emma S Tomlinson Guns
We have explored the effects of 20(S)-protopanaxadiol (aPPD), a naturally derived ginsenoside, against androgen receptor (AR) positive castration resistant prostate cancer (CRPC) xenograft tumors and have examined its interactions with AR. In silico docking studies for aPPD binding to AR, alongside transactivation bioassays and in vivo efficacy studies were carried out in the castration-resistant C4-2 xenograft model. Immunohistochemical (IHC) and Western blot analyses followed by evaluation of AR, apoptotic, cell cycle and proliferative markers in excised tumors was performed...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29762891/assistants-in-nursing-working-with-mental-health-consumers-in-the-emergency-department
#5
Adam Gerace, Eimear Muir-Cochrane, Deb O'Kane, Leah Couzner, Christine Palmer, Karleen Thornton
Nursing students, regardless of setting, require skills in working with people with mental health issues. One way to provide students with learning opportunities within the context of limited undergraduate mental health content and lack of mental health placements is through employment as assistants in nursing (AIN). The purpose of the study was to investigate the use of AINs employed in an emergency department in South Australia to supervise (continuous observation) mental health consumers on inpatient treatment orders...
May 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29762794/teaching-competencies-for-community-preceptors
#6
Darin Brink, Deb Simpson, Byron Crouse, Jeffrey Morzinski, Douglas Bower, Ruth Westra
BACKGROUND AND OBJECTIVES: Although community physicians provide one-fourth of the outpatient training received in medical school, usually there is no formal training of the preceptor. Currently there is no agreed-upon list of teaching competencies for community physician-preceptors. Using a modified Delphi process, the authors aimed to identify core teaching competencies for community preceptors for use in training and evaluation. METHODS: A medical educator and three faculty members with expertise in faculty development created a list of teaching competencies organized in five domains...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29760947/incorporating-epilepsy-genetics-into-clinical-practice-a-360%C3%A2-evaluation
#7
Stephanie Oates, Shan Tang, Richard Rosch, Rosalie Lear, Elaine F Hughes, Ruth E Williams, Line H G Larsen, Qin Hao, Hans Atli Dahl, Rikke S Møller, Deb K Pal
We evaluated a new epilepsy genetic diagnostic and counseling service covering a UK population of 3.5 million. We calculated diagnostic yield, estimated clinical impact, and surveyed referring clinicians and families. We costed alternative investigational pathways for neonatal onset epilepsy. Patients with epilepsy of unknown aetiology onset < 2 years; treatment resistant epilepsy; or familial epilepsy were referred for counseling and testing. We developed NGS panels, performing clinical interpretation with a multidisciplinary team...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29758662/brownian-dynamics-of-self-regulated-particles-with-additional-degrees-of-freedom-symmetry-breaking-and-homochirality
#8
Debankur Bhattacharyya, Shibashis Paul, Shyamolina Ghosh, Deb Shankar Ray
We consider the Brownian motion of a collection of particles each with an additional degree of freedom. The degree of freedom of a particle (or, in general, a molecule) can assume distinct values corresponding to certain states or conformations. The time evolution of the additional degree of freedom of a particle is guided by those of its neighbors as well as the temperature of the system. We show that the local averaging over these degrees of freedom results in emergence of a collective order in the dynamics in the form of selection or dominance of one of the isomers leading to a symmetry-broken state...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756140/synthesis-of-unsymmetrical-multi-aroyl-derivatives-of-ferrocene-using-palladium-catalysed-oxidative-c-h-aroylation
#9
Mayukh Deb, Susanta Hazra, Ajay Gupta, Anil J Elias
A palladium catalysed methodology for mono-selective oxidative aroylation of ferrocene has been achieved. 10 mol% of Pd(OAc)2 was used as the catalyst for this radical aroylation reaction using O-methyl-oxime as the directing group. tert-Butyl hydroperoxide was used as an oxidant and both aldehydes and alcohols were used as acyl-equivalents. The protocol has been extended to aryl, heteroaryl and sterically hindered aroylating agents. Acidic-hydrolysis with 6(N) HCl of the directing group resulted in unsymmetrically substituted ketone derivatives of ferrocene, which have not been achieved otherwise...
May 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29744106/disordered-eating-behaviour-in-young-adults-with-type-1-diabetes-mellitus
#10
S Keane, M Clarke, M Murphy, D McGrath, D Smith, N Farrelly, S MacHale
Background: The combination of eating disorders and diabetes is associated with increased risk of morbidity and mortality. The aim of this study is to compare the prevalence of disordered eating behaviour (DEB) in young adults with type 1 diabetes mellitus to a sample of non-diabetic controls, and to examine the relationship of DEB to glycaemic control. Methods: The Eating Disorder Examination Questionnaire (EDE-Q) was administered to 51 individuals aged 18-30 years attending an outpatient diabetic clinic in a large university teaching hospital...
2018: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29742099/the-amp-project-comparing-species-on-the-basis-of-dynamic-energy-budget-parameters
#11
Gonçalo M Marques, Starrlight Augustine, Konstadia Lika, Laure Pecquerie, Tiago Domingos, Sebastiaan A L M Kooijman
We developed new methods for parameter estimation-in-context and, with the help of 125 authors, built the AmP (Add-my-Pet) database of Dynamic Energy Budget (DEB) models, parameters and referenced underlying data for animals, where each species constitutes one database entry. The combination of DEB parameters covers all aspects of energetics throughout the full organism's life cycle, from the start of embryo development to death by aging. The species-specific parameter values capture biodiversity and can now, for the first time, be compared between animals species...
May 9, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29739489/safety-and-efficacy-analysis-of-deb-tace-treatment-in-elderly-patients-with-hepatocellular-carcinoma-a-comparative-cohort-study
#12
Qing Yang, Xiaosheng Jin, Fangpeng Ye, Bingru Zheng, Xiangpang Xie, Ya Luo, Zhenjing Shi, Changsheng Shi
The aim of this study was to explore the difference of liver function change, safety profiles and efficacy of drug-eluting bead transarterial chemoembolization (DEBTACE) therapy between elderly and middle-aged hepatocellular carcinoma (HCC) patients. 91 HCC patients were enrolled in this prospective cohort study. They were treated by DEB-TACE therapy and divided into elderly group (age >= 65 years, n=30) and middle-aged group (age < 65 years, n=61), liver function, safety profiles and treatment response were recorded...
May 8, 2018: Oncology Research
https://www.readbyqxmd.com/read/29738542/microvascular-retinopathy-and-angiographically-demonstrated-coronary-artery-disease-a-cross-sectional-observational-study
#13
Lisa Cheng, Peter Barlis, Joel Gibson, Deb Colville, Anastasia Hutchinson, Geoff Gleeson, Ecosse Lamoureux, William VanGaal, Judy Savige
Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score...
2018: PloS One
https://www.readbyqxmd.com/read/29736356/implementation-and-preliminary-analysis-of-fact-g-quality-of-life-questionnaire-within-an-oncology-survivorship-clinic
#14
Reyna Colombo, Deb J Doherty, Christopher M Wilson, Kodie Krzys, Sarah Lange, Hayley Maynes
PURPOSE: To conduct a descriptive analysis of the results from the Functional Assessment of Cancer Therapy-General (FACT-G) quality of life (QOL) questionnaire, describe the outcomes from the FACT-G to drive treatment recommendations within the breast survivorship clinic and to quantify the severity of QOL issues experienced. METHODS: A retrospective analysis utilizing medical records of participants in a breast cancer survivorship clinic. Measurement data included demographics and FACT-G results...
March 5, 2018: Curēus
https://www.readbyqxmd.com/read/29730076/changing-the-quality-of-life-in-old-age-bariatric-patients-cross-sectional-study-for-79-old-age-patients
#15
Elie Chouillard, Salman Alsabah, Elias Chahine, Elias Saikaly, Tarek Debs, Radwan Kassir
PURPOSE: Bariatric surgery is being safely performed in elderly patients. However, current recommendations lack precise indications for bariatric surgery and fail to define an upper age limit for surgical procedure, leaving the field wide open to case by case assessment according to patient's physiological age and benefit-to-risk balance. OBJECTIVES: The aim of this study is to evaluate the quality of life of obese patients older than 60 years one year after bariatric surgery, and to compare the variation of their nutritional parameters to those of matched younger patients...
May 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29729091/systemic-low-frequency-oscillations-observed-in-the-periphery-of-healthy-human-subjects
#16
Yingwei Li, Haibing Zhang, Meiling Yu, Weiwei Yu, Blaise deB Frederick, Yunjie Tong
This study investigated the relationships of systemic low-frequency oscillations (sLFOs) measured at different peripheral sites in resting state, during passive leg raising (PLR), and during a paced breathing (PB) test. Twenty-five healthy subjects (21 to 57 years old; males: 13 and females: 12) were recruited for these experiments. During the experiments, the fluctuations of oxyhemoglobin concentration were measured at six peripheral sites (left and right toes, fingertips, and earlobes) using a multichannel near-infrared spectroscopy instrument developed by our group...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29726942/colorado-s-new-proxy-law-allowing-physicians-to-serve-as-proxies-moving-from-statute-to-guidelines
#17
Jacqueline J Glover, Deb Bennett-Woods, Jean Abbott
In 2016, the Colorado legislature passed an amendment to Colorado's medical proxy law that established a process for the appointment of a physician to act as proxy decision maker of last resort for an unrepresented patient (Colorado HB 16-1101: Medical Decisions For Unrepresented Patients). The legislative process brought together a diverse set of stakeholders, not all of whom supported the legislation. Following passage of the statutory amendment, the Colorado Collaborative for Unrepresented Patients (CCUP), a group of advocates responsible for initiating the legislative process, coordinated a unique effort to engage these stakeholders in the creation of a set of voluntary guidelines to assist facilities and individual careproviders in the implementation of policies and procedures enabled by the statute...
2018: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/29717667/hepatoprotective-effect-of-auricularia-delicata-agaricomycetes-from-india-in-rats-biochemical-and-histopathological-studies-and-antimicrobial-activity
#18
Sujata Devi Wangkheirakpam, Devi Datt Joshi, Geeta Devi Leishangthem, Dipak Biswas, Lokesh Deb
Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, India, for various gastrointestinal and liver ailments. This study evaluates the antioxidant, antimicrobial, and hepatoprotective potential of A. delicata. A. delicata fruiting bodies were extracted with hexane, chloroform, ethyl acetate, and methanol. All these extracts were examined for in vitro antioxidant activity. To study antimicrobial activity, minimum inhibitory concentrations (milligrams per milliliter) were determined through the use of the broth dilution method...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29712764/the-grief-of-mothers-after-the-sudden-unexpected-death-of-their-infants
#19
Richard D Goldstein, Ruth I Lederman, Wendy G Lichtenthal, Sue E Morris, Melanie Human, Amy J Elliott, Deb Tobacco, Jyoti Angal, Hein Odendaal, Hannah C Kinney, Holly G Prigerson
: media-1vid110.1542/5741323271001PEDS-VA_2017-3651 Video Abstract BACKGROUND: The loss of a child is associated with elevated grief severity, and sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality in the United States. The diagnosis of prolonged grief disorder (PGD) has gained broader acceptance and use. Little is known about PGD in mothers after SIDS. METHODS: Between May 2013 and July 2016, we assessed 49 SIDS-bereaved mothers living in informal settlements near Cape Town, South Africa, and on the Pine Ridge Indian Reservation and 359 SIDS-bereaved mothers affiliated with SIDS parent-support organizations in the United States, United Kingdom, Australia, New Zealand, and the Netherlands...
April 30, 2018: Pediatrics
https://www.readbyqxmd.com/read/29707564/comparative-study-between-ethanolic-and-%C3%AE-cyclodextrin-assisted-extraction-of-polyphenols-from-peach-pomace
#20
Nada El Darra, Hiba N Rajha, Espérance Debs, Fatima Saleh, Iman El-Ghazzawi, Nicolas Louka, Richard G Maroun
Peach byproducts are often regarded as food waste despite their high content in health-promoting components. Amongst the latter, polyphenols are bioactive molecules with significant health benefits. The present study investigated an eco-friendly and cost-effective method using a GRAS food additive, β -cyclodextrin ( β -CD), for the recovery of polyphenols from peach pomace. β -CD assisted extraction of polyphenols was compared to that of conventional solvent (ethanol) extraction at the same concentrations (10 mg/mL, 20 mg/mL, 30 mg/mL, 40 mg/mL, and 50 mg/mL) in terms of quality (antiradical activity) and quantity...
2018: International Journal of Food Science
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