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https://www.readbyqxmd.com/read/29352230/histology-immunohistochemistry-and-in-situ-hybridization-reveal-overlooked-ebola-virus-target-tissues-in-the-ebola-virus-disease-guinea-pig-model
#1
Timothy K Cooper, Louis Huzella, Joshua C Johnson, Oscar Rojas, Sri Yellayi, Mei G Sun, Sina Bavari, Amanda Bonilla, Randy Hart, Peter B Jahrling, Jens H Kuhn, Xiankun Zeng
Survivors of Ebola virus infection may become subclinically infected, but whether animal models recapitulate this complication is unclear. Using histology in combination with immunohistochemistry and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we demonstrate for the first time Ebola virus infection in hepatic oval cells, the endocardium and stroma of the atrioventricular valves and chordae tendinae, satellite cells of peripheral ganglia, neurofibroblasts and Schwann cells of peripheral nerves and ganglia, smooth muscle cells of the uterine myometrium and vaginal wall, acini of the parotid salivary glands, thyroid follicular cells, adrenal medullary cells, pancreatic islet cells, endometrial glandular and surface epithelium, and the epithelium of the vagina, penis and, prepuce...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351088/fraction-variant-beam-orientation-optimization-for-non-coplanar-imrt
#2
Daniel O'Connor, Victoria Yu, Dan Nguyen, Dan Ruan, Ke Sheng
Conventional beam orientation optimization (BOO) algorithms for IMRT assume that the same set of beam angles is used for all treatment fractions. In this paper we present a BOO formulation based on group sparsity that simultaneously optimizes non-coplanar beam angles for all fractions, yielding a fraction-variant (FV) treatment plan. Beam angles are selected by solving a multi-fraction fluence map optimization problem involving 500-700 candidate beams per fraction, with an additional group sparsity term that encourages most candidate beams to be inactive...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29348283/unusual-feathery-cause-of-a-parapharyngeal-abscess-in-an-infant
#3
Wai Sum Cho, Mihaela Nistor, Kishan Ubayasiri, Mark Johnston
A 7-month-old boy presented to the emergency department with reduced oral intake, neck swelling and fever. Clinical examination revealed a 3 cm left parotid and left level I neck swelling with left medialised tonsil but no trismus. Computed imaging confirmed the presence of an abscess in the peritonsillar area with extension into the parapharyngeal space and deep lobe of the parotid gland. The abscess was incised and drained transorally. Following drainage of the abscess, a small 3 mm suspicious foreign body was seen...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29346263/clinical-application-of-real-time-shear-wave-elastography-in-identifying-the-histological-components-of-parotid-adenolymphoma
#4
Kun Huang, Ningning Gao, Xuemei Wang, Donglin Bian, Yanjun Liu, Qixi Zhai
OBJECTIVE: This study aimed to investigate the relationship between the elastic modulus and the histological components of parotid adenolymphoma by using real-time shear wave elastography. METHODS: A total of 157 patients, histologically confirmed as having parotid adenolymphoma, were enrolled in the study. The maximum and the mean elastic modulus of the parotid mass were measured by using preoperative shear wave elastography. Parotid adenolymphoma was histopathologically subdivided into different types based on the relative proportion of stromal to cellular components...
January 17, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29344775/new-saliva-secretion-model-based-on-the-expression-of-na-k-pump-and-k-channels-in-the-apical-membrane-of-parotid-acinar-cells
#5
János Almássy, Elias Siguenza, Marianna Skaliczki, Klara Matesz, James Sneyd, David I Yule, Péter P Nánási
The plasma membrane of parotid acinar cells is functionally divided into apical and basolateral regions. According to the current model, fluid secretion is driven by transepithelial ion gradient, which facilitates water movement by osmosis into the acinar lumen from the interstitium. The osmotic gradient is created by the apical Cl- efflux and the subsequent paracellular Na+ transport. In this model, the Na+-K+ pump is located exclusively in the basolateral membrane and has essential role in salivary secretion, since the driving force for Cl- transport via basolateral Na+-K+-2Cl- cotransport is generated by the Na+-K+ pump...
January 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29344484/adenocarcinoma-of-the-retinal-pigment-epithelium-arising-in-conjunction-with-late-recurrence-and-systemic-metastasis-of-retinoblastoma
#6
Kelsey Roelofs, Femida Kherani, Laurie Russell, J Godfrey Heathcote, Ezekiel Weis
In 1974, an 8-month-old male was diagnosed with bilateral retinoblastoma. His left eye was enucleated, while the right eye was salvaged with a combination of external beam radiotherapy (4,000 cGy total, divided in 20 fractions) and retinal laser treatment. Thirty-nine years later, he developed intraocular recurrence of retinoblastoma with extrascleral spread. Histopathological examination also identified a second distinct malignancy, retinal pigment epithelium adenocarcinoma, arising in continuity with the retinoblastoma...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29337642/perineural-invasion-in-parotid-gland-malignancies
#7
Phillip Huyett, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Barry M Schaitkin, Seungwon Kim
Objectives To investigate the clinical predictors and survival implications of perineural invasion (PNI) in parotid gland malignancies. Study Design Case series with chart review. Setting Tertiary care medical center. Subjects and Methods Patients with parotid gland malignancies treated surgically from 2000 to 2015 were retrospectively identified in the Head and Neck Cancer Registry at a single institution. Data points were extracted from the medical record and original pathology reports. Results In total, 186 patients with parotid gland malignancies were identified with a mean follow-up of 5...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29333769/-significance-of-the-expression-of-proliferating-cell-nuclear-antigen-and-p53-in-the-regeneration-process-of-an-atrophic-parotid-gland
#8
Wei Yueduan, Zuo Jinhua, Ding Changling, Zhu Yuhong, Wang Lifang, Song Bing, Wang Jing
OBJECTIVE: This research aims to further explore the expression and significance of proliferating cell nuclear antigen (PCNA) and P53 in regenerating rat atrophy parotid gland from the gene and protein levels. METHODS: One hundred and two Wistar rats were randomly divided into experimental and control groups; the former group's duct was ligated and then released respectively in 7 (Group A) and 14 days (Group B). Fresh parotid specimens were obtained at 0, 3, 5, 7, 10, 14, 21, and 28 days after being released...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333123/evaluation-of-deformable-image-registration-dir-methods-for-dose-accumulation-in-nasopharyngeal-cancer-patients-during-radiotherapy
#9
Wannapha Nobnop, Imjai Chitapanarux, Hudsaleark Neamin, Somsak Wanwilairat, Vicharn Lorvidhaya, Taweap Sanghangthum
Introduction: Deformable image registration (DIR) is used to modify structures according to anatomical changes for observing the dosimetric effect. In this study, megavoltage computed tomography (MVCT) images were used to generate cumulative doses for nasopharyngeal cancer (NPC) patients by various DIR methods. The performance of the multiple DIR methods was analysed, and the impact of dose accumulation was assessed. Patients and methods: The study consisted of five NPC patients treated with a helical tomotherapy unit...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29332268/methylmercury-intoxication-promotes-metallothionein-response-and-cell-damage-in-salivary-glands-of-rats
#10
Leidiane Alencar de Oliveira Lima, Leonardo Oliveira Bittencourt, Bruna Puty, Rafael Monteiro Fernandes, Priscila Cunha Nascimento, Marcia Cristina Freitas Silva, Sérgio Melo Alves-Junior, João de Jesus Viana Pinheiro, Rafael Rodrigues Lima
Environmental and occupational mercury exposure is considered a major public health issue. Despite being well known that MeHg exposure causes adverse effects in several physiologic functions, MeHg effects on salivary glands still not completely elucidated. Here, we investigated the cellular MeHg-induced damage in the three major salivary glands (parotid, submandibular, and sublingual) of adult rats after chronic, systemic and low doses of MeHg exposure. Rats were exposed by 0.04 mg/kg/day over 60 days. After that, animals were euthanized and all three glands were collected...
January 14, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29327783/nonsurgical-management-of-human-immunodeficiency-virus-associated-parotid-cysts-a-systematic-review-and-meta-analysis
#11
Akash N Naik, William B Clinkscales, Masanari G Kato, Shaun A Nguyen, M Boyd Gillespie
BACKGROUND: The purpose of this clinical review was to analyze the effectiveness of nonsurgical management options for human immunodeficiency virus (HIV)-associated parotid cysts. METHODS: We conducted systematic and meta-analysis reviews. Primary outcomes were complete or partial responses. RESULTS: Systematic review identified 12 relevant studies. The average rates of complete response for antiretroviral therapy (ART), sclerotherapy, and fine-needle aspiration (FNA) were 52...
January 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/29321485/role-of-diffusion-weighted-imaging-in-the-discrimination-of-benign-and-metastatic-parotid-area-lymph-nodes-in-patients-with-nasopharyngeal-carcinoma
#12
Chuanben Chen, Zhizhong Lin, Youping Xiao, Penggang Bai, Qiuyuan Yue, Yunbin Chen, Lisha Chen
To assess the utility of apparent diffusion coefficient (ADC) determined on diffusion-weighted MR imaging (DWI) to differentiate between benign and malignant parotid area lymph nodes (PLN) in nasopharyngeal carcinoma (NPC) patients. Thirty-nine consecutive NPC patients with a total of 40 enlarged, biopsied PLNs underwent DWI examination. ADC values for benign and malignant PLNs were measured and compared. Receiver operating characteristic (ROC) curve analysis was to evaluate the optimal threshold level of ADC values for metastatic PLNs...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315960/proton-change-of-parotid-glands-after-gustatory-stimulation-examined-by-magnetic-resonance-imaging
#13
Yi-Jui Liu, Yi-Hsiung Lee, Hing-Chiu Chang, Hui-Chu Chiu, Ta-Wei Chiu, Kang Hsu, Cheng-Ming Pen, Hsian-He Hsu, Chun-Jung Juan
The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined 20 parotid glands from 10 healthy volunteers (male:female = 6: 4; age ± standard deviation =35.1 ± 14.1 years) with written informed consent obtained. All participants underwent 1.5-T, double-echo EPI with gustatory stimulation...
January 8, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29304190/enhancement-of-saltiness-perception-by-monosodium-glutamate-taste-and-soy-sauce-odor-a-near-infrared-spectroscopy-study
#14
Takuya Onuma, Hiroaki Maruyama, Nobuyuki Sakai
Previous studies have reported that the umami taste of monosodium L-glutamate (MSG) and salty-smelling odors (e.g., soy sauce, bacon, sardines) enhance the perception of saltiness. This study aimed to investigate the neural basis of the enhancement of saltiness in human participants using functional near-infrared spectroscopy (fNIRS). University students who had passed a taste panel test participated in this study. Sodium chloride solutions were presented with or without either 0.10% MSG or the odor of soy sauce...
January 3, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29302899/salivary-duct-carcinoma-and-invasive-ductal-carcinoma-of-the-breast-a-comparative-immunohistochemical-study
#15
Jalal B Jalaly, Souzan Sanati, Rebecca D Chernock, Dikson G Dibe, Samir K El-Mofty
Salivary duct carcinoma (SDC) is a high-grade salivary gland malignancy with great morphological resemblance to invasive ductal carcinoma (IDC) of the breast. Rarely, female patients may have a past history of both SDC and IDC. When these patients present with distant metastasis, accurate identification of the primary tumor is particularly difficult. Additionally, rare metastasis of SDC to the breast and IDC to the salivary (parotid) gland can also present a diagnostic challenge. Our aim was to develop an immunohistochemical panel that reliably distinguishes SDC from IDC...
January 4, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29301803/extramedullary-plasmacytoma-rare-neoplasm-of-parotid-gland
#16
Sehrish Abrar, Nasir Ali, Bilal Mazhar Qureshi, Ahmed Nadeem Abbasi
A 45-year-old man presented with left-sided facial swelling. Initial excisional biopsy was done somewhere else without prior imaging and it came out to be pleomorphic adenoma; local imaging after biopsy showed mass over the left parotid gland with ipsilateral lymphadenopathy. On examination, there was a well-circumscribed mass with signs of left facial nerve palsy. He underwent left radical parotidectomy with ipsilateral modified radical neck dissection, and per operatively, it came out to be neoplastic lesion...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29299096/a-case-report-of-mikulicz-syndrome
#17
Dinesh Rao, Patrick Natter, Rui Fernandes, Zhiqiang Brad Wang, Sukhwinder Johnny Singh Sandhu
Mikulicz Syndrome (MS) is a rare chronic condition characterized by the abnormal enlargement of glandular tissue in the head and neck. Patients usually present with enlarged lacrimal and parotid glands. While this can be a benign self-limiting condition, other complex systemic diseases, such as sarcoidosis, may represent other underlying etiologies. We present a case of MS in a patient with a history of Crohn's disease.
July 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29297939/technical-note-the-impact-of-deformable-image-registration-methods-on-dose-warping
#18
An Qin, Jian Liang, Xiao Han, Nicolette O'Connell, Di Yan
PURPOSE: To investigate the clinical-relevant discrepancy between doses warped by pure-image based deformable image registration (IM-DIR) and by biomechanical-model based DIR (BM-DIR) on intensity homogeneous organs. METHODS AND MATERIALS: Ten patients (5Head&Neck, 5Prostate) were included. A research DIR tool (ADMRIE_v1.12) was utilized for IM-DIR. After IM-DIR, BM-DIR was carried out for organs (parotids, bladder, and rectum) which often encompass sharp dose gradient...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29297184/an-algorithm-for-preoperative-differential-diagnostics-of-parotid-tumors-on-the-basis-of-their-dynamic-and-diffusion-weighted-mr-images-a-retrospective-analysis-of-158-cases
#19
Bogusław Mikaszewski, Karolina Markiet, Aneta Smugała, Dominik Stodulski, Edyta Szurowska, Czesław Stankiewicz
BACKGROUND: To verify the usefulness of a new algorithm for preoperative differential diagnostics of parotid tumors on the basis of their dynamic and diffusion-weighted MR images. METHODS: The retrospective analysis included 158 consecutive surgical patients with parotid tumors. Aside from ultrasound-guided fine needle biopsy, the protocol of preoperative evaluation included dynamic and diffusion-weighted MRI. According to the new diagnostic algorithm, the result of fine needle biopsy was considered only in the case of lesions with time to peak enhancement (Tpeak) > 60 s and washout rate (WR) ≤ 30% on dynamic MRI and apparent diffusion coefficient (ADC) ≤ 1...
January 3, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29288583/applications-of-3-dimensional-ultrasonography-in-the-neck-excluding-the-thyroid
#20
Susan J Frank, Tova Koenigsberg, David Gutman, Mordecai Koenigsberg
Ultrasonography (US) of the neck is an accepted, useful imaging modality for many applications beyond its usefulness in thyroid disease. Two-dimensional US has been effectively used for evaluation of many types of neck conditions, and now, 3-dimensional US can be added to the imaging armamentaria. Three-dimensional US is useful in the evaluation of cervical lymph nodes, recurrent/residual thyroid neoplasia, parathyroid glands, parotid and submandibular glands, as well as thyroglossal duct cysts and other assorted palpable and visible abnormalities because of its unique capabilities, including multiplanar reconstruction, accessibility of the coronal view, volume calculation, and regularly spaced incremental slice evaluation...
December 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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