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https://www.readbyqxmd.com/read/28342945/cognitive-impairment-in-first-episode-drug-na%C3%A3-ve-patients-with-schizophrenia-relationships-with-serum-concentrations-of-brain-derived-neurotrophic-factor-and-glial-cell-line-derived-neurotrophic-factor
#1
Wenhuan Xiao, Fei Ye, Chunlai Liu, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia. METHODS: The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28337410/damage-to-white-matter-bottlenecks-contributes-to-language-impairments-after-left-hemispheric-stroke
#2
Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski
Damage to the white matter underlying the left posterior temporal lobe leads to deficits in multiple language functions. The posterior temporal white matter may correspond to a bottleneck where both dorsal and ventral language pathways are vulnerable to simultaneous damage. Damage to a second putative white matter bottleneck in the left deep prefrontal white matter involving projections associated with ventral language pathways and thalamo-cortical projections has recently been proposed as a source of semantic deficits after stroke...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28334687/neurocognitive-status-in-patients-with-newly-diagnosed-brain-tumors-in-good-neurological-condition-the-impact-of-tumor-type-volume-and-location
#3
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Neurocognitive function is of great importance in patients with brain tumors. Even patients in good neurological condition may suffer from neurocognitive dysfunction that affects their daily living. The purpose of the present study was to identify risk factors for neurocognitive dysfunction in patients suffering from common supratentorial brain tumors with minor neurological deficits. METHODS: A prospective study evaluating neurocognitive dysfunction in patients with a newly-diagnosed brain tumor in good neurological condition was performed at a major German academic institution...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#4
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332040/edinburgh-cognitive-and-behavioural-als-screen-ecas-italian-version-regression-based-norms-and-equivalent-scores
#5
Mattia Siciliano, Luigi Trojano, Francesca Trojsi, Roberta Greco, Manuela Santoro, Giuseppe Basile, Fausta Piscopo, Alfonsina D'Iorio, Manila Patrone, Cinzia Femiano, Mariarosaria Monsurrò, Gioacchino Tedeschi, Gabriella Santangelo
Cognitive assessment for individuals with Amyotrophic Lateral Sclerosis (ALS) can be difficult because of frequent occurrence of difficulties with speech, writing, and drawing. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a recent multi-domain neuropsychological screening tool specifically devised for this purpose, and it assesses the following domains: executive functions, social cognition, verbal fluency and language (ALS-specific), but also memory and visuospatial abilities (Non-ALS specific)...
March 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28330458/the-effects-of-an-extensive-exercise-programme-on-the-progression-of-mild-cognitive-impairment-mci-study-protocol-for-a-randomised-controlled-trial
#6
Kate E Devenney, Brian Lawlor, Marcel G M Olde Rikkert, Stefan Schneider
BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI...
March 22, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28327626/altered-resting-state-hippocampal-functional-networks-associated-with-chemotherapy-induced-prospective-memory-impairment-in-breast-cancer-survivors
#7
Huaidong Cheng, Wen Li, Liang Gong, Han Xuan, Zhonglian Huang, Hong Zhao, Long Sheng Wang, Kai Wang
In this study, we aimed to investigate the intrinsic hippocampal functional connectivity (FC) network and its relationship with prospective memory in patients with breast cancer suffering from chemotherapy-induced cognitive impairment (CICI). Thirty-four breast cancer patients before and after adjuvant chemotherapy (CB and CC, respectively) and 31 age- and education-matched cognitively normal (CN) women were recruited and subjected to a prospective memory task and a resting-state functional magnetic resonance imaging scan...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323092/the-effect-of-deep-brain-stimulation-of-the-subthalamic-nucleus-on-executive-functions-impaired-verbal-fluency-and-intact-updating-planning-and-conflict-resolution-in-parkinson-s-disease
#8
Gyula Demeter, István Valálik, Péter Pajkossy, Agnes Szőllősi, Ágnes Lukács, Ferenc Kemény, Mihály Racsmány
Although the improvement of motor symptoms in Parkinson's disease (PD) after Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is well documented, there are open questions regarding its impact on cognitive functions. The aim of the present study was to assess the effect of bilateral DBS of the STN on executive functions in PD patients using a DBS wait-listed PD control group. Ten PD patients with DBS implantation (DBS group) and ten PD wait-listed patients (Clinical control group) participated in the study...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28320224/identification-of-common-neural-circuit-disruptions-in-cognitive-control-across-psychiatric-disorders
#9
Lisa M McTeague, Julia Huemer, David M Carreon, Ying Jiang, Simon B Eickhoff, Amit Etkin
OBJECTIVE: Cognitive deficits are a common feature of psychiatric disorders. The authors investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis. METHOD: A PubMed search was conducted for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with axis I disorders and matched healthy control participants during cognitive control tasks...
March 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28304305/combined-dual-task-gait-training-and%C3%A2-aerobic-exercise-to-improve-cognition-%C3%A2-mobility-and%C3%A2-vascular-health-in%C3%A2-community-dwelling-older-adults-at%C3%A2-risk-for-future-cognitive-decline1
#10
Michael A Gregory, Narlon C Boa Sorte Silva, Dawn P Gill, Cheri L McGowan, Teresa Liu-Ambrose, J Kevin Shoemaker, Vladimir Hachinski, Jeff Holmes, Robert J Petrella
This 6-month experimental case series study investigated the effects of a dual-task gait training and aerobic exercise intervention on cognition, mobility, and cardiovascular health in community-dwelling older adults without dementia. Participants exercised 40 min/day, 3 days/week for 26 weeks on a Biodex GaitTrainer2 treadmill. Participants were assessed at baseline (V0), interim (V1: 12-weeks), intervention endpoint (V2: 26-weeks), and study endpoint (V3: 52-weeks). The study outcomes included: cognition [executive function (EF), processing speed, verbal fluency, and memory]; mobility: usual & dual-task gait (speed, step length, and stride time variability); and vascular health: ambulatory blood pressure, carotid arterial compliance, and intima-media thickness (cIMT)...
March 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28295013/impact-of-familial-loading-on-prefrontal-activation-in-major-psychiatric-disorders-a-near-infrared-spectroscopy-nirs-study
#11
Kazutaka Ohi, Takamitsu Shimada, Hiroaki Kihara, Toshiki Yasuyama, Kazuyuki Sawai, Yukihisa Matsuda, Kazuaki Oshima, Hiroaki Okubo, Yusuke Nitta, Takashi Uehara, Yasuhiro Kawasaki
Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and typically exhibit more severe impairments. Decreased prefrontal activity during verbal fluency testing (VFT) may constitute an intermediate phenotype for PSY. We investigated whether familial PSY were associated with a greater severity of prefrontal dysfunction in accordance with genetic loading. We measured prefrontal activity during VFT using near-infrared spectroscopy (NIRS) in patients with schizophrenia (SCZ, n = 45), major depressive disorder (MDD, n = 26) or bipolar disorder (BIP, n = 22) and healthy controls (HC, n = 51)...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294477/identifying-neurocognitive-markers-for-outcome-prediction-of-global-functioning-in-ultra-high-risk-for-psychosis-and-first-episode-psychosis
#12
Kingo Sawada, Akiko Kanehara, Satoshi Eguchi, Mariko Tada, Yoshihiro Satomura, Motomu Suga, Shinsuke Koike, Kiyoto Kasai
AIM: There is an increasing need for identifying neurocognitive predictors of global functional outcome in early psychosis toward optimizing early intervention strategy. METHODS: We conducted a longitudinal observational study to investigate an association between neurocognitive assessments at baseline and global functional outcome at an average of one-year follow-up. Participants included ultra-high-risk for psychosis (UHR) individuals who had not converted to psychosis during the follow-up period (UHR-NP), and those with first-episode psychosis (FEP) individuals...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28293187/comparison-of-cognitive-change-after-working-memory-training-and-logic-and-planning-training-in-healthy-older-adults
#13
Vina M Goghari, Linette Lawlor-Savage
Recent attention has focused on the benefits of cognitive training in healthy adults. Many commercial cognitive training programs are available given the attraction of not only bettering one's cognitive capacity, but also potentially preventing age-related declines, which is of particular interest to older adults. The issue of whether cognitive training can improve performance within cognitive domains not trained (i.e., far transfer) is controversial, with meta-analyses of cognitive training both supporting and falsifying this claim...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28293062/near-infrared-spectroscopy-reveals-abnormal-hemodynamics-in-the-left-dorsolateral-prefrontal-cortex-of-menopausal-depression-patients
#14
Xiang-Yun Ma, Yong-Jun Wang, Bo Xu, Kun Feng, Gao-Xiang Sun, Xiao-Qian Zhang, Xiao-Min Liu, Chen-Yu Shen, Xia-Jin Ren, Jing-Jing Sun, Po-Zi Liu
Background/Objective. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD. Methods. The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS). Results. We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18, P = 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28292650/frontal-and-temporal-cortical-functional-recovery-after-electroconvulsive-therapy-for-depression-a-longitudinal-functional-near-infrared-spectroscopy-study
#15
Jinichi Hirano, Akihiro Takamiya, Bun Yamagata, Syogo Hotta, Yukiko Miyasaka, Shenghong Pu, Akira Iwanami, Hiroyuki Uchida, Masaru Mimura
While the efficacy and tolerability of electroconvulsive therapy (ECT) for depression has been well established, the acute effects of ECT on brain function remain unclear. Particularly, although cognitive dysfunction has been consistently observed after ECT, little is known about the extent and time course of ECT-induced brain functional changes, as observed during cognitive tasks. Considering the acute antidepressant effects of ECT on depression, aberrant brain functional responses during cognitive tasks in patients with depression may improve immediately after this treatment...
February 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28288547/neuropsychological-correlates-of-schizotypy-a-systematic-review-and-meta-analysis-of-cross-sectional-studies
#16
Sara Siddi, Donatella Rita Petretto, Antonio Preti
INTRODUCTION: Cognitive deficits can precede the onset of psychotic episodes and predict the onset of the illness in individuals with schizotypy traits. In some studies, high levels of schizotypy were associated with impairments in memory, attention, executive functions, and verbal fluency. This review provides a more comprehensive understanding of cognitive impairments related to schizoytpy. METHODS:  A systematic review of "schizotypy and neuropsychological measures" was conducted, and it retrieved 67 studies...
March 13, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28286473/neurocognitive-predictors-of-response-in-treatment-resistant-depression-to-subcallosal-cingulate-gyrus-deep-brain-stimulation
#17
Shane J McInerney, Heather E McNeely, Joseph Geraci, Peter Giacobbe, Sakina J Rizvi, Amanda K Ceniti, Anna Cyriac, Helen S Mayberg, Andres M Lozano, Sidney H Kennedy
Background: Deep brain stimulation (DBS) is a neurosurgical intervention with demonstrated effectiveness for treatment resistant depression (TRD), but longitudinal studies on the stability of cognitive parameters following treatment are limited. The objectives of this study are to (i) identify baseline cognitive predictors of treatment response to subcallosal cingulate gyrus (SCG) DBS for unipolar TRD and (ii) compare neurocognitive performance prior to and 12 months after DBS implantation. Methods: Twenty unipolar TRD patients received SCG DBS for 12 months...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28285181/gender-differences-of-neuropsychological-profiles-in-cognitively-normal-older-people-without-amyloid-pathology
#18
Jie Zhang, Wenjun Zhou, Lijun Wang, Xiangyang Zhang
OBJECTIVE: To investigate the impact of sex on cognition among cognitively normal older people without amyloid pathology. METHODS: The study sample consisted of 83 males (mean age 74years, ranging from 65 to 88years) and 111 females (mean age 72years, ranging from 65 to 89years) who were cognitively normal without amyloid pathology confirmed by Pittsburgh compound B PET scan. We examined the sex discrepancies in cognition using a comprehensive neuropsychological battery...
March 1, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28284581/cognitive-function-surrounding-resection-of-nonfunctioning-pituitary-adenomas-with-suprasellar-extension-a-prospective-matched-control-study
#19
Philipp Hendrix, Christoph J Griessenauer, Elisa Hans, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Patients suffering from pituitary adenomas may experience cognitive dysfunctions due to hormonal imbalance or suprasellar tumor extension displacing neural structures. Progressively enlarging or symptomatic nonfunctioning pituitary adenomas with suprasellar extension are frequently resected. The literature on neurocognitive performance surrounding resection of these lesions is sparse. METHODS: A prospective matched-control study was conducted to investigate the impact of nonfunctioning pituitary adenomas with suprasellar extension on preoperative and postoperative cognitive performance...
March 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28280646/meta-analysis-of-the-relationship-between-deep-brain-stimulation-in-patients-with-parkinson-s-disease-and-performance-in-evaluation-tests-for-executive-brain-functions
#20
REVIEW
A M Martínez-Martínez, O M Aguilar, C A Acevedo-Triana
Parkinson's disease (PD) is a neurodegenerative condition, which compromises the motor functions and causes the alteration of some executive brain functions. The presence of changes in cognitive symptoms in PD could be due to the procedure of deep brain stimulation (DBS). We searched in several databases for studies that compared performance in executive function tests before and after the DBS procedure in PE and then performed a meta-analysis. After the initial search, there were 15 articles that specifically evaluated the functions of verbal fluency, working memory, cognitive flexibility, abstract thinking, and inhibition...
2017: Parkinson's Disease
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