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https://www.readbyqxmd.com/read/29248614/significant-association-between-catechol-o-methyltransferase-comt-val158-108met-polymorphism-and-cognitive-function-in-veterans-with-ptsd
#1
Ana Havelka Mestrovic, Lucija Tudor, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Zrnka Kovacic Petrovic, Dubravka Svob Strac, Marcela Konjevod, Nela Pivac
Core features of posttraumatic stress disorder (PTSD) are cognitive disturbances. Enzyme catechol-O-methyltransferase (COMT) degrades dopamine primarily in prefrontal cortex. Its functional polymorphism, COMT Val158/108Met, affects COMT activity and dopamine availability and is associated with disturbances in cognition. The hypothesis was that PTSD subjects will have worse working memory than healthy controls and that the carriers of the COMT Met allele will show better cognitive performance compared to Val/Val carriers in PTSD and controls subjects...
December 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29237555/real-world-navigation-in-amnestic-mild-cognitive-impairment-the-relation-to-visuospatial-memory-and-volume-of-hippocampal-subregions
#2
Jessica Peter, Richard Sandkamp, Lora Minkova, Lena V Schumacher, Christoph P Kaller, Ahmed Abdulkadir, Stefan Klöppel
Spatial disorientation is a frequent symptom in Alzheimer's disease and in mild cognitive impairment (MCI). In the clinical routine, spatial orientation is less often tested with real-world navigation but rather with 2D visuoconstructive tasks. However, reports about the association between the two types of tasks are sparse. Additionally, spatial disorientation has been linked to volume of the right hippocampus but it remains unclear whether right hippocampal subregions have differential involvement in real-world navigation...
December 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29213506/symptoms-of-depression-in-patients-with-mild-cognitive-impairment-in-parkinson-s-disease
#3
Ana Lara Soares Blum Malak, Luiz Felipe Vasconcellos, João Santos Pereira, Denise Vieira Greca, Manuela Cruz, Heloisa Veiga Dias Alves, Mariana Sptiz, Helenice Charchat-Fichman
Objective: To investigate the most frequent depressive symptoms and their association with cognition in Parkinson's disease (PD) patients with mild cognitive impairment (MCI). Methods: 48 patients with PD and 44 controls (CG), aged between 50 and 80 years and with at least 4 years of formal education, all with MCI and none diagnosed with depression, were assessed. Patients and controls were matched for age, education, and Mini-Mental State Examination (MMSE) score...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29202381/set-shifting-and-visuospatial-organization-deficits-in-body-dysmorphic-disorder
#4
Jennifer L Greenberg, Hilary Weingarden, Lillian Reuman, Dylan Abrams, Suraj S Mothi, Sabine Wilhelm
Individuals with body dysmorphic disorder (BDD) over-attend to perceived defect(s) in their physical appearance, often becoming "stuck" obsessing about perceived flaws and engaging in rituals to hide flaws. These symptoms suggest that individuals with BDD may experience deficits in underlying neurocognitive functions, such as set-shifting and visuospatial organization. These deficits have been implicated as risk and maintenance factors in disorders with similarities to BDD but have been minimally investigated in BDD...
November 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29198217/what-does-it-take-to-search-organized-the-cognitive-correlates-of-search-organization-during-cancellation-after-stroke
#5
Antonia F Ten Brink, Johanna M A Visser-Meily, Tanja C W Nijboer
OBJECTIVES: Stroke could lead to deficits in organization of visual search. Cancellation tests are frequently used in standard neuropsychological assessment and appear suitable to measure search organization. The current aim was to evaluate which cognitive functions are associated with cancellation organization measures after stroke. METHODS: Stroke patients admitted to inpatient rehabilitation were included in this retrospective study. We performed exploratory factor analyses to explore cognitive domains...
December 4, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29185057/implications-of-a-paediatrician-psychologist-tandem-for-sickle-cell-disease-care-and-impact-on-cognitive-functioning
#6
Adrienne Lerner, Hervé Picard, Adrien May, Vincent Gajdos, Louise Malou-Dhaussy, Flaviana Maroja-Cox, Laurence Salomon, Marie-Hélène Odièvre
Sickle cell disease (SCD), a life-threatening chronic disease, necessitates a paediatric treatment plan that considers the influence of psychological, family and intercultural factors. At the Louis-Mourier Hospital (APHP) in Colombes, France, we introduced an original paediatric-psychological partnership where a clinical psychologist accompanies the paediatrician at programmed consultations. We evaluated children and their parents treated in Colombes and in two other paediatric units using standardized culture-free tools and clinical interviews to evaluate the psychological repercussions of SCD...
November 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29116821/memory-and-linguistic-executive-functions-of-children-with-borderline-intellectual-functioning
#7
Andrea B Água Dias, Cristina P Albuquerque, Mário R Simões
Children with Borderline Intellectual Functioning (BIF) have received a minimal amount of research attention and have been studied in conjunction with Intellectual and Developmental Disabilities. The present study intends to broaden the knowledge of BIF, by analyzing domains such as verbal memory and visual memory, as well as tasks that rely simultaneously on memory, executive functions, and language. A cross-sectional, comparison study was carried out between a group of 40 children with BIF (mean age = 10...
November 8, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29100951/distinct-cerebellar-regions-related-to-motor-and-cognitive-performance-in-sca6-patients
#8
Zubir Rentiya, Noore-Sabah Khan, Ezgi Ergun, Sarah H Ying, John E Desmond
OBJECTIVE: To demonstrate a correlation between anatomic regional changes in Spinocerebellar Ataxia type 6 (SCA6) patients and measures of cognitive performance on neuropsychological tests. METHODS: Neurocognitive testing was conducted on 24 SCA6 and 28 control subjects. For each cognitive test, SCA6 patients were compared against the controls using Student's t-test. For the cerebellar patients, using voxel based morphometry, correlations between cerebellar gray matter volume at each voxel and performance on the neuropsychological exams were calculated using the Pearson correlation coefficient implemented in SPM8...
October 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29058552/executive-and-nonexecutive-demands-of-constructional-measures-within-a-children-s-psychiatric-inpatient-setting
#9
Jane Studeny, Elyssa Weber, Brian C Kavanaugh, Jennifer A Dupont-Frechette, Perrin P Tellock, Isolde D Maher, Lauren D Haisley, Kyle McCurdy, Karen A Holler
This study examined the role of executive functioning in constructional task performance (measured with the Rey Complex Figure Test-Copy Condition [RCFT] and Beery-Buktenica Developmental Test of Visual-Motor Integration [Beery-VMI]) within a children's psychiatric inpatient setting. A chart review was conducted for 88 children (aged 6-12) who received a neuropsychological evaluation during a psychiatric inpatient hospitalization. Multiple regression analyses investigated the role of executive and nonexecutive demands on RCFT and Beery-VMI performance...
October 23, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29031302/fast-quantitation-of-opioid-isomers-in-human-plasma-by-differential-mobility-spectrometry-mass-spectrometry-via-spme-open-port-probe-sampling-interface
#10
Chang Liu, Germán Augusto Gómez-Ríos, Bradley B Schneider, J C Yves Le Blanc, Nathaly Reyes-Garcés, Don W Arnold, Thomas R Covey, Janusz Pawliszyn
Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed figures of merit. However, in most cases, such processes are not optimal for urgent assessments and high-throughput determinations. The direct coupling of solid phase microextraction (SPME) to MS has shown great potential to shorten the total sample analysis time of complex matrices, as well as to diminish potential matrix effects and instrument contamination...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29031167/impaired-central-coherence-in-patients-with-anorexia-nervosa
#11
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Hiroko Kubo, Masashi Ohta, Yukio Tada, Yukiko Tomioka, Shinya Watanabe, Masatoshi Inoshita, Makoto Kinoshita, Tetsuro Ohmori
The purpose of this study was to investigate the characteristics of central coherence in patients with anorexia nervosa (AN). 22 female patients with AN (median age = 31.50 (QD = 8.13) years) and 33 female healthy controls (HC) (median age = 28.00 (QD = 8.50) years) participated in the study. Their central coherence was assessed with the Rey Complex Figure Task (RCFT). Clinical symptoms were evaluated with the Beck Depression Inventory-II and the State-Trait Anxiety Inventory-Form JYZ. The results showed that AN patients' Central Coherence Index and accuracy scores in copy, 3-min delayed recall and 30-min delayed recall tasks of the RCFT were significantly lower than those of HC...
September 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28979230/visual-constructional-ability-in-individuals-with-severe-obesity-rey-complex-figure-test-accuracy-and-the-q-score
#12
Hanna L Sargénius, Frederick W Bylsma, Stian Lydersen, Knut Hestad
The aims of this study were to investigate visual-construction and organizational strategy among individuals with severe obesity, as measured by the Rey Complex Figure Test (RCFT), and to examine the validity of the Q-score as a measure for the quality of performance on the RCFT. Ninety-six non-demented morbidly obese (MO) patients and 100 healthy controls (HC) completed the RCFT. Their performance was calculated by applying the standard scoring criteria. The quality of the copying process was evaluated per the directions of the Q-score scoring system...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28951142/cognitive-deficit-in-patients-with-paranoid-schizophrenia-its-clinical-and-laboratory-correlates
#13
Mariia Dorofeikova, Nikolay Neznanov, Nataliia Petrova
The aim of this study was to search for correlates of cognitive impairment in patients with paranoid schizophrenia among clinical, demographic, anamnestic and biochemical markers (NSE, S100B protein, BDNF, hs-CRP). Patients with paranoid schizophrenia (n=125) were examined using the Brief Assessment of Cognitive Function in Schizophrenia, the Rey-Osterrieth Complex Figure task, and a number of clinical scales including the Positive and Negative Syndrome Scale. The majority of patients demonstrated cognitive impairment...
September 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28923433/the-association-between-symptoms-of-autism-and-neuropsychological-performance-in-females-with-anorexia-nervosa
#14
Heather Westwood, William Mandy, Kate Tchanturia
The aim of this study was to investigate the relationship between symptoms of autism spectrum disorder (ASD) and performance on measures of set-shifting and central coherence in a sample of females with anorexia nervosa (AN). Ninety-nine females aged 12-47, recruited from inpatient and day patient eating disorder services, were assessed with the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2), as well as the Wechsler Abbreviated Scale of Intelligence, 2nd edition (WASI-II); Wisconsin Card Sorting Test (WCST); Rey-Osterrieth Complex Figure Test (ROCFT) and self-report questionnaires assessing eating disorder pathology, depression, cognitive rigidity and attention to detail...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28892766/the-cognitive-profile-of-myotonic-dystrophy-type-1-%C3%A2-a-systematic-review-and-meta-analysis
#15
REVIEW
Kees Okkersen, Melanie Buskes, Johannes Groenewoud, Roy P C Kessels, Hans Knoop, Baziel van Engelen, Joost Raaphorst
OBJECTIVE: To examine the cognitive profile of patients with myotonic dystrophy type 1 (DM1) on the basis of a systematic review and meta-analysis of the literature. METHODS: Embase, Medline and PsycInfo were searched for studies reporting ≥1 neuropsychological test in both DM1 patients and healthy controls. Search, data extraction and risk of bias analysis were independently performed by two authors to minimize error. Neuropsychological tests were categorized into 12 cognitive domains and effect sizes (Hedges' g) were calculated for each domain and for tests administered in ≥5 studies...
August 16, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28885225/rey-osterrieth-complex-figure-copy-and-immediate-recall-3-minutes-normative-data-for-spanish-speaking-pediatric-populations
#16
J C Arango-Lasprilla, D Rivera, M M Erlt, J M Muñoz Mancilla, C E García-Guerrero, W Rodriguez-Irizarry, A Aguayo Arelis, Y Rodríguez-Agudelo, M D Barrios Nevado, M Vélez-Coto, T P Yacelga Ponce, A Rigabert, C García de la Cadena, S Pohlenz Amador, E Vergara-Moragues, M Soto-Añari, A I Peñalver Guia, M Saracostti Schwartzman, R Ferrer-Cascales
OBJECTIVE: To generate normative data for the Rey- Osterrieth Complex Figure (ROCF) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the ROCF as part of a larger neuropsychological battery. The ROCF copy and immediate recall (3 minutes) scores were normed using multiple linear regressions and standard deviations of residual values...
September 5, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28873362/impact-of-hippocampal-subfield-histopathology-in-episodic-memory-impairment-in-mesial-temporal-lobe-epilepsy-and-hippocampal-sclerosis
#17
Sandra Mara Comper, Anaclara Prada Jardim, Jeana Torres Corso, Larissa Botelho Gaça, Maria Helena Silva Noffs, Carmen Lúcia Penteado Lancellotti, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Elza Márcia Targas Yacubian
OBJECTIVE: The objective of the study was to analyze preoperative visual and verbal episodic memories in a homogeneous series of patients with mesial temporal lobe epilepsy (MTLE) and unilateral hippocampal sclerosis (HS) submitted to corticoamygdalohippocampectomy and its association with neuronal cell density of each hippocampal subfield. METHODS: The hippocampi of 72 right-handed patients were collected and prepared for histopathological examination. Hippocampal sclerosis patterns were determined, and neuronal cell density was calculated...
September 2, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28869475/effect-of-attention-training-in-mild-cognitive-impairment-patients-with-subcortical-vascular-changes-the-rehatt-study
#18
Leonardo Pantoni, Anna Poggesi, Stefano Diciotti, Raffaella Valenti, Stefano Orsolini, Eleonora Della Rocca, Domenico Inzitari, Mario Mascalchi, Emilia Salvadori
BACKGROUND AND OBJECTIVE: Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial. METHODS: Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28865717/measuring-learning-potential-in-people-with-schizophrenia-a-comparison-of-two-tasks
#19
Melisa V Rempfer, Joan M McDowd, Catana E Brown
Learning potential measures utilize dynamic assessment methods to capture performance changes following training on a cognitive task. Learning potential has been explored in schizophrenia research as a predictor of functional outcome and there have been calls for psychometric development in this area. Because the majority of learning potential studies have utilized the Wisconsin Card Sorting Test (WCST), we extended this work using a novel measure, the Rey Osterrieth Complex Figure Test (ROCFT). This study had the following aims: 1) to examine relationships among different learning potential indices for two dynamic assessment tasks, 2) to examine the association between WCST and ROCFT learning potential measures, and 3) to address concurrent validity with a performance-based measure of functioning (Test of Grocery Shopping Skills; TOGSS)...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28844148/the-association-of-apolipoprotein-e-gene-polymorphism-with-cognitive-performance-in-nondemented-polish-adults-aged-55-to-75
#20
Małgorzata T Piskunowicz, Katarzyna Linkowska, Szymon Gołota, Tomasz Grzybowski, Kornelia Kędziora-Kornatowska, Alina Borkowska
The ε4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for dementia. How APOE ε polymorphism affects cognitive performance in nondemented aging subjects remains less clear. In this study, the relationship between APOE status and cognitive performance across various cognitive domains in adults aged 55 to 75 years ( n = 74) without dementia was investigated. E4 carriers ( n = 11) performed worse versus noncarriers on forward Digit Span and delayed recall of the Rey-Osterrieth complex figure...
January 1, 2017: International Journal of Aging & Human Development
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