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https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#1
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27890303/cognitive-effects-of-creatine-monohydrate-adjunctive-therapy-in-patients-with-bipolar-depression-results-from-a-randomized-double-blind-placebo-controlled-trial
#2
REVIEW
Ricardo Alexandre Toniolo, Francy de Brito Ferreira Fernandes, Michelle Silva, Rodrigo da Silva Dias, Beny Lafer
BACKGROUND: Depressive episodes and cognitive impairment are major causes of morbidity and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment approaches that target clinical and cognitive aspects of bipolar depression are needed, and research on pathophysiology suggests that mitochondrial modulators such as the nutraceutical creatine monohydrate might have a therapeutic role for this condition. METHODS: Eighteen (N=18) patients with bipolar depression according to DSM-IV criteria who were enrollled in a 6-week, randomized, double-blind, placebo-controlled trial of creatine monohydrate 6g daily as adjunctive therapy were submitted to neuropsychological assessments (Wisconsin Card Sorting Test, Digit Span subtest of the Wechsler Adult Intelligence Scale-Third Edition, Stroop Color-Word Test, Rey-Osterrieth complex figure test, FAS Verbal Fluency Test) at baseline and week 6...
November 20, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27887913/prospective-assessment-of-cosmesis-before-and-after-genital-surgery
#3
N J Nokoff, B Palmer, A J Mullins, C E Aston, P Austin, L Baskin, K Bernabé, Y-M Chan, E Y Cheng, D A Diamond, A Fried, D Frimberger, D Galan, L Gonzalez, S Greenfield, T Kolon, B Kropp, Y Lakshmanan, S Meyer, T Meyer, L L Mullins, A Paradis, D Poppas, P Reddy, M Schulte, K J Scott Reyes, J M Swartz, C Wolfe-Christensen, E Yerkes, A B Wisniewski
INTRODUCTION: Little data exist about the surgical interventions taking place for children with disorders of sex development (DSD). Most studies that have evaluated cosmetic outcomes after genitoplasty have included retrospective ratings by a physician at a single center. OBJECTIVE: The present study aimed to: 1) describe frequency of sex assignment, and types of surgery performed in a cohort of patients with moderate-to-severe genital ambiguity; and 2) prospectively determine cosmesis ratings by parents and surgeons before and after genital surgery...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27834087/accrual-to-cancer-clinical-trial
#4
C Kelly, M Smith, S Flynn, A Reyes, M Higgins, J McCaffrey, C Kelly
Accrual to cancer clinical trials (CCT) is imperative to safeguard continued improvement in cancer outcomes. A retrospective chart review was performed of patients (n=140) starting a new anti-cancer agent in a north Dublin cancer centre. This review was performed over a four-month period, beginning in November 2015. Only 29% (n=41) had a CCT option. The overall accrual rate to CCT was 5% (n=7), which is comparable to internationally reported figures. The main reasons for failure to recruit to CCT included the lack of a CCT option for cancer type (n=30, 23%), stage (n=25, 19%), and line of treatment (n=23, 17%)...
August 8, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27831757/developing-a-virtual-reality-based-vocational-rehabilitation-training-program-for-patients-with-schizophrenia
#5
Bo Kyung Sohn, Jae Yeon Hwang, Su Mi Park, Jung-Seok Choi, Jun-Young Lee, Ji Yeuon Lee, Hee-Yeon Jung
Maintaining employment is difficult for patients with schizophrenia because of deterioration of psychosocial and cognitive functions. Such patients usually require vocational rehabilitation training, which is both demanding and costly. In this study, we developed a virtual reality-based vocational rehabilitation training program (VR-VRTP) for such patients and evaluated its feasibility as an alternative to traditional rehabilitation programs. We developed the VR-VRTP to include various situations commonly encountered in two types of occupations: convenience store employee and supermarket clerk...
November 2016: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/27806073/central-coherence-in-eating-disorders-a-synthesis-of-studies-using-the-rey-osterrieth-complex-figure-test
#6
Katie Lang, Marion Roberts, Amy Harrison, Carolina Lopez, Elizabeth Goddard, Mizan Khondoker, Janet Treasure, Kate Tchanturia
BACKGROUND: Large variability in tests and differences in scoring systems used to study central coherence in eating disorders may lead to different interpretations, inconsistent findings and between study discrepancies. This study aimed to address inconsistencies by collating data from several studies from the same research group that used the Rey Osterrieth Complex Figure Test (Rey Figure) in order to produce norms to provide benchmark data for future studies. METHOD: Data was collated from 984 participants in total...
2016: PloS One
https://www.readbyqxmd.com/read/27776264/memory-related-white-matter-tract-integrity-in-amyotrophic-lateral-sclerosis-an-advanced-neuroimaging-and-neuropsychological-study
#7
Foteini Christidi, Efstratios Karavasilis, Ioannis Zalonis, Panagiotis Ferentinos, Zoi Giavri, Elisabeth A Wilde, Sophia Xirou, Michalis Rentzos, Vasiliki Zouvelou, George Velonakis, Panagiotis Toulas, Efstathios Efstathopoulos, Loukia Poulou, Georgios Argyropoulos, Athanasios Athanasakos, Thomas Zambelis, Harvey S Levin, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis
We aimed to investigate structural changes in vivo in memory-related white matter tracts (i.e., perforant pathway zone [PPZ]; uncinate fasciculus [UF]; fornix) using diffusion tensor tractography and evaluate possible associations with memory performance in nondemented patients with amyotrophic lateral sclerosis (ALS). Forty-two ALS patients and 25 healthy controls (HCs) underwent a 30-directional diffusion-weighted imaging on a 3T MR scanner, followed by tractography of PPZ, UF, and fornix and analysis of fractional anisotropy (FA), axial diffusivity and radial diffusivity (Dr)...
September 28, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27753292/trying-to-remember-effort-mediates-the-relationship-between-frequency-of-cannabis-use-and-memory-performance
#8
Rayna B Hirst, Kaitlyn R Young, Louise M Sodos, Robert E Wickham, Mitch Earleywine
INTRODUCTION: While many studies suggest that regular cannabis use leads to deficits in cognitive functioning, particularly in memory, few have measured effort put forth during testing, and none have examined this as a potential mediator. Both age of onset of regular cannabis use and frequency of use have been linked to increased risk of memory deficits. The present study sought to determine whether effort mediated the relationship between frequency or age of onset of cannabis use and learning and memory performance...
October 18, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27737811/effects-of-manganese-exposure-on-visuoperception-and-visual-memory-in-schoolchildren
#9
D Hernández-Bonilla, C Escamilla-Núñez, D Mergler, S Rodríguez-Dozal, M Cortez-Lugo, S Montes, L A Tristán-López, M Catalán-Vázquez, A Schilmann, Horacio Riojas-Rodriguez
BACKGROUND: Manganese (Mn) is an essential metal involved in multiple physiological functions. Environmental exposure to airborne Mn is associated with neurocognitive deficits in humans. Children, whose nervous system is in development, are particularly susceptible to Mn neurotoxicity. OBJECTIVE: The objective of this study was to assess the association between Mn environmental exposure, and effects on visuoperception and visual memory in schoolchildren. METHODS: We assessed schoolchildren between 7 and 11 years old, with similar socioeconomic status, from the mining district of Molango (n=148) and Agua Blanca (n=119, non-mining area) in Hidalgo state, Mexico...
October 11, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27736663/accounting-for-ethnic-cultural-and-linguistic-diversity-in-neuropsychological-assessment-of-patients-with-drug-resistant-epilepsy-a-retrospective-study
#10
Valeria Peviani, Pina Scarpa, Alessio Toraldo, Gabriella Bottini
Neuropsychological assessment is critical in both diagnosis and prognosis of patients with epilepsy. Beyond electrophysiological and anatomical alterations, other factors including different ethnic-cultural and linguistic backgrounds might affect neuropsychological performance. Only a few studies considered migration and acculturation effects and they typically concerned nonclinical samples. The current study aimed at investigating the influence of ethnic background and time spent in Italy on a full neuropsychological battery administered to both Italian and foreign-born patients and at providing a brief interview for obtaining relevant information on each patient's transcultural and language-related history...
October 10, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27725006/visuospatial-memory-improvement-in-patients-with-diffuse-axonal-injury-dai-a-1-year-follow-up-study
#11
Ana Luiza Zaninotto, Jessica Elias Vicentini, Davi Jorge Fontoura Solla, Tatiana Tateishi Silva, Vinicius Monteiro de Paula Guirado, Fabrício Feltrin, Mara Cristina Souza de Lucia, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
OBJECTIVE: Diffuse axonal injury (DAI) is prevalent in traumatic brain injury (TBI), and is often associated with poor outcomes and cognitive impairment, including memory deficits. Few studies have explored visual memory after TBI and its relationship to executive functioning. Executive functioning is crucial for remembering an object's location, operating devices, driving, and route finding. We compared visual memory performance via the Rey-Osterrieth Complex Figure (ROCF) test 6 and 12 months after DAI...
October 11, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27704340/evaluation-of-individual-cognitive-remediation-therapy-crt-for-the-treatment-of-young-people-with-anorexia-nervosa
#12
Lucia Giombini, Jennifer Moynihan, Matteo Turco, Sophie Nesbitt
PURPOSE: Research suggests that there are cognitive inefficiencies underlying Anorexia Nervosa (AN), with CRT showing promise in improving these inefficiencies in adults. This area has yet to be explored in a younger population. The aim of this study was to evaluate the use of CRT for young people. METHODS: A within-subjects design was used to compare the performance of children and adolescents with AN on several neuropsychological measures administered before and after a course of CRT...
October 4, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27683847/cognitive-reserve-in-frontotemporal-degeneration-neuroanatomic-and-neuropsychological-evidence
#13
Katerina Placek, Lauren Massimo, Christopher Olm, Kylie Ternes, Kim Firn, Vivianna Van Deerlin, Edward B Lee, John Q Trojanowski, Virginia M-Y Lee, David Irwin, Murray Grossman, Corey T McMillan
OBJECTIVE: To evaluate if cognitive reserve (CR) contributes to interindividual differences in frontal gray matter density (GMD) and executive impairment that underlie heterogeneity in the disease course of confirmed frontotemporal lobar degeneration (FTLD) pathology. METHODS: Fifty-five patients with autopsy confirmation or a pathogenic mutation consistent with underlying tau (FTLD-tau) or TDP-43 (FTLD-TDP) pathology and 90 demographically comparable healthy controls were assessed with T1 MRI and neuropsychological measures (Mini-Mental State Examination, letter fluency, forward digit span, Rey complex figure, and Boston Naming Test)...
October 25, 2016: Neurology
https://www.readbyqxmd.com/read/27676988/cognitive-impairments-and-impact-on-activities-of-daily-living-after-minor-stroke
#14
Philippine Dassonville, Stuart Nash, Valérie Servajean, Monique Sanchez, Stéphanie Mazza, Pascale Colliot, Sophie Jacquin-Courtois, Evelyne Klinger, Anne-Marie Schott, Laure Huchon, Laura Mechtouff, Laurent Derex, Norbert Nighoghossian, Tae-Hee Cho, Gilles Rode
OBJECTIVE: Describe cognitive impairments and their impact on activities of daily living after a minor stroke in the context of a "pilote" consultation done in hospices civils de Lyon between vascular neurology and physical and rehabilitation services. MATERIAL/PATIENTS AND METHODS: Thirty patients (21-67 years old) who have cognitive difficulties 6 months after minor stroke were included in the study. All patients received an assessment of complaints and cognitive performances (Montreal cognitive assessment scale, verbal span, 16 items free and cued recall, doors test, rey figure, symbol digit modalities test, verbal fluences, trail making test and the virtual action planning-supermarket test)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27658980/leukoencephalopathy-and-long-term-neurobehavioural-neurocognitive-and-brain-imaging-outcomes-in-survivors-of-childhood-acute-lymphoblastic-leukaemia-treated-with-chemotherapy-a-longitudinal-analysis
#15
Yin Ting Cheung, Noah D Sabin, Wilburn E Reddick, Deepa Bhojwani, Wei Liu, Tara M Brinkman, John O Glass, Scott N Hwang, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Leukoencephalopathy is observed in some children undergoing chemotherapy for acute lymphoblastic leukaemia, although its effects on long-term outcomes is unknown. This study examines the associations between acute leukoencephalopathy and neurobehavioural, neurocognitive, and brain white matter imaging outcomes in long-term survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy without cranial radiation. METHODS: In this longitudinal analysis, we used data of children with acute lymphoblastic leukaemia at St Jude Children's Research Hospital (Memphis, TN, USA) who had been treated between June 1, 2000, and Oct 31, 2010...
October 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27637389/cannabis-use-related-to-early-psychotic-onset-role-of-premorbid-function
#16
Marianna Frascarelli, Adele Quartini, Lorenzo Tomassini, Paola Russo, Daiana Zullo, Giorgiana Manuali, Sergio De Filippis, Giuseppe Bersani
The present cross-sectional study investigates the relation between Cannabis and the development of a psychotic disorder. The main objective is to explore the relations between Cannabis use and psychosis onset, premorbid adjustment cognitive impairment and familiarity. Forty-three patients with a diagnosis of Psychotic Disorder were recruited and divided in two groups based on Cannabis use before onset: Cannabis-using patients (PCU, N=21) and Cannabis-free patients (PCF, N=22). Cognitive functioning was evaluated by Trail Making Test A and B (TMT), Rey-Osterrieth Complex Figure Test (ROCF), and the Rey Auditory-Verbal Learning Test (RAVLT)...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27629091/synergistic-effects-of-longitudinal-amyloid-and-vascular-changes-on-lobar-microbleeds
#17
Yeo Jin Kim, Hee Jin Kim, Jae-Hyun Park, Seonwoo Kim, Sook-Young Woo, Ki-Chang Kwak, Jong Min Lee, Na-Yeon Jung, Jae Seung Kim, Yearn Seong Choe, Kyung-Han Lee, Seung Hwan Moon, Jae-Hong Lee, Yun Joong Kim, David J Werring, Duk L Na, Sang Won Seo
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI). METHODS: Among 72 patients with svMCI who underwent brain MRI and [(11)C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed the third year of follow-up. These patients were evaluated by annual neuropsychological testing, brain MRI, and follow-up PiB-PET...
October 11, 2016: Neurology
https://www.readbyqxmd.com/read/27583141/magnitude-and-variability-of-effect-sizes-for-the-associations-between-chronic-pain-and-cognitive-test-performances-a-meta-analysis
#18
Michél Rathbone, William Parkinson, Yasir Rehman, Shucui Jiang, Mohit Bhandari, Dinesh Kumbhare
OBJECTIVES AND METHODS: A systematic review and meta-analysis were performed to estimate the size and variability of the association between chronic pain (CP) and poorer cognitive test performances as a function of individual tests, pain sub-types, and study sources on 22 studies having (1) a control group, (2) reported means and standard deviations (SDs) and (3) tests studied at least 3 times. RESULTS: CP patients performed significantly poorer with small to moderate effects (d = -...
August 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27537344/assessment-intervention-using-the-rey-osterrieth-complex-figure-test-a-clinical-illustration
#19
Anna Sapozhnikova, Bruce L Smith
Therapeutic assessment (TA) aims to affect change in a client, in part, through an in vivo intervention using any number of assessment methods during a planned assessment intervention session (AIS). To date, neuropsychological tests have not been widely used in AIS. We suggest that the Rey-Osterrieth Complex Figure Test (RCFT) can be a helpful tool, especially when the assessment questions pertain to cognitive functioning, owing to its complexity and the fact that it taps several different cognitive functions...
August 18, 2016: Journal of Personality Assessment
https://www.readbyqxmd.com/read/27461110/representational-pseudoneglect-for-detecting-changes-to-rey-osterrieth-figures
#20
Ellie Aniulis, Owen Churches, Nicole A Thomas, Michael E R Nicholls
When dividing attention between the left and right sides of physical space, most individuals pay slightly more attention to the left side. This phenomenon, known as pseudoneglect, may also occur for the left and right sides of mental representations of stimuli. Representational pseudoneglect has been shown for the recall of real-world scenes and for simple, briefly presented stimuli. The current study sought to investigate the effect of exposure duration and complexity using adaptations of the Rey-Osterrieth figures...
July 26, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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