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https://www.readbyqxmd.com/read/29783265/-international-experience-in-the-legal-regulation-of-the-circulation-of-medicines-through-the-prism-of-the-law-of-the-world-trade-organization
#1
Olena V Pasechnyk, Nataliia V Hendel
OBJECTIVE: Introduction: The development of international legal cooperation in the field of health has largely been driven by the trade interests of states. The aim: The article analyzes the legal regulation of the circulation of medicines through the prism of the law of the World Trade Organization. PATIENTS AND METHODS: Materials and methods: Using the historical legal method has allowed to analyze the genesis of legal regulation of the circulation of medicines through the prism of the law of the World Trade Organization...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783250/-signifuing-resident-of-the-city-poltava-at-the-expense-of-signs-stroke-risk-factors-and-urgent-measures-according-to-medico-social-survey
#2
Anzhelina M Kryvchun, Nataliia V Lytvynenko, Viktoriia A Pinchuk, Galyna Ya Sylenko, Viktoriia M Gladka
OBJECTIVE: Introduction: The problem of cerebrovascular diseases and their most severe form - cerebral stroke is one of the most pressing problems in modern medicine due to the high level of lethality, significant disability of patients. The aim: To assess and increase the sign of residents of the city Poltava at the expense of signs of stroke, its risk factors for emergence and emergency measures for stroke. PATIENTS AND METHODS: Materials and methods: During the annual social event dedicated to the World Stroke Day, on October 27, 2017, a survey of 981 people in Poltava city was conducted by volunteer students and staff of the Department of Nervous Diseases with Neurosurgery and Medical Genetics of "Ukrainian Medical Stomatological Academy"...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783078/delayed-bipolar-and-ganglion-cells-neuroretinal-processing-in-regular-cannabis-users-the-retina-as-a-relevant-site-to-investigate-brain-synaptic-transmission-dysfunctions
#3
Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Anne Giersch, Laurence Lalanne, Eliane Albuisson, Vincent Laprevote
Cannabis use is widespread worldwide, but the impact of smoking cannabis regularly on brain synaptic transmission has only been partially elucidated. The retina is considered as an easy means of determining dysfunction in brain synaptic transmission. The endocannabinoid system is involved in regulating retinal synaptic transmission, which might also be affected by tobacco. Previous preliminary results have shown impairments in retinal ganglion cell response in cannabis users. Here, we test the extent to which earlier retinal levels-bipolar cells and photoreceptors-are affected in cannabis users, i...
May 1, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29782166/toxicokinetics-tissue-distribution-and-excretion-of-dufulin-racemate-and-its-r-s-enantiomers-in-rats
#4
Huaguo Chen, Xin Zhou, Baoan Song
Dufulin is a plant antiviral agent with a novel molecular structure and has been used widely to prevent and control tobacco and rice viral diseases. In this study, an UHPLC-MS/MS assay was developed for rapid determination of dufulin racemate (rac-DFL) and its R (S)-enantiomers in rat plasma, tissues, urine and feces. A MALDI-MSI method was further used to visual research on tissue distribution after oral administration of the three analytes. Toxicokinetic study showed that both (R)-enantiomers of dufulin ((R)-DFL) and (S)-enantiomers of dufulin ((S)-DFL) had a faster ability to reach Cmax than that of rac-DFL...
May 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29781683/tuberculosis-non-communicable-disease-comorbidity-and-multimorbidity-in-public-primary-care-patients-in-south-africa
#5
Karl Peltzer
BACKGROUND:  Little is known about the prevalence of non-communicable disease (NCD) multimorbidity among tuberculosis (TB) patients in Africa.Aim and setting: The aim of this study was to assess the prevalence of NCD multimorbidity, its pattern and impact on adverse health outcomes among patients with TB in public primary care in three selected districts of South Africa. METHODS:  In a cross-sectional survey, new TB and TB retreatment patients were interviewed, and medical records assessed in consecutive sampling within 1 month of anti-TB treatment...
April 11, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29781659/nicotine-deprivation-increases-pain-intensity-neurogenic-inflammation-and-mechanical-hyperalgesia-among-daily-tobacco-smokers
#6
Joseph W Ditre, Emily L Zale, Lisa R LaRowe, Jesse D Kosiba, Martin J De Vita
An evolving reciprocal model posits that pain and tobacco smoking behavior interact in the manner of a positive feedback loop, resulting in greater pain and the maintenance of nicotine dependence. There is also reason to believe that abstaining from smoking may increase pain during the early stages of smoking cessation. The goal of this study was to test the effects of nicotine deprivation on experimental pain reactivity. Daily tobacco cigarette smokers (N = 165; 43% female) were randomized to either extended nicotine deprivation (12-24 hr smoking abstinence), minimal deprivation (2 hr smoking abstinence), or continued smoking conditions, prior to undergoing pain induction via topical capsaicin...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29781639/tobacco-use-and-smoking-behaviors-of-individuals-with-a-serious-mental-illness
#7
Donna Pettey, Tim Aubry
OBJECTIVES: The purpose of this study was to determine the prevalence of tobacco use and overall smoking behaviors within a sample of individuals with a serious mental illness who were homeless or vulnerably housed and receiving community mental health services. METHODS: In 2010, individuals (N = 639) were interviewed, and identified smokers completed the Fagerström Test for Nicotine Dependence (FTND) and additional questions related to their smoking behaviors...
May 21, 2018: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/29781627/triple-trajectories-of-alcohol-use-tobacco-use-and-depressive-symptoms-as-predictors-of-cannabis-use-disorders-among-urban-adults
#8
Jung Yeon Lee, Judith S Brook, Wonkuk Kim
Heavy cannabis use is associated with a wide array of physical, mental, and functional problems. Therefore, cannabis use disorders (CUDs) may be a major public health concern. Given the adverse health consequences of CUDs, the present study seeks to find possible precursors of CUDs. The current study consisted of 5 waves of data collection from the Harlem Longitudinal Development Study. Among 816 participants, about half are African Americans (52%), and the other half are Puerto Ricans (48%). We used Mplus to obtain the triple trajectories of alcohol use, tobacco use, and depressive symptoms...
May 21, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29781588/smoking-in-systemic-sclerosis-a-longitudinal-european-scleroderma-trials-and-research-group-study
#9
Veronika K Jaeger, Gabriele Valentini, Eric Hachulla, Franco Cozzi, Oliver Distler, Paolo Airó, Laszlo Czirják, Yannick Allanore, Elise Siegert, Edoardo Rosato, Marco Matucci-Cerinic, Cristian Caimmi, Jörg Henes, Patricia E Carreira, Vanessa Smith, Francesco Del Galdo, Christopher P Denton, Susanne Ullman, Ellen De Langhe, Valeria Riccieri, Juan J Alegre-Sancho, Simona Rednic, Ulf Müller-Ladner, Ulrich A Walker
OBJECTIVES: Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR database. METHODS: Adult SSc patients with data on smoking history and a 12-24 months follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the comprehensive smoking index (CSI) were assessed using multivariable regression analyses...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29781460/targeting-nicotine-addiction
#10
Ellen Carr
Smoking cessation remains a high priority in oncology nursing practice. That priority gained additional visibility in 2014 when the Oncology Nursing Society (ONS) endorsed the tobacco position statement of the International Society of Nurses in Cancer Care, emphasizing the potential for nurses to reduce adult and youth tobacco use.
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29780790/association-of-youth-characteristics-and-recent-utilization-of-dental-services-in-the-united-states
#11
Ilana R A Chertok, Nathaniel Chertok, Zelalem T Haile, Bhakti Chavan
Background: Oral health is important for overall health of youth, although dental service utilization is lower than national goals. The purpose of the study was to identify sociodemographic and health behavioral characteristics of youth in the United States who reported having at least one dental visit in the past 12 months. Methods: Secondary data analysis was conducted using the 2015 Youth Risk Behavior Survey (YRBS) to examine factors associated with dental care utilization using Andersen's theory-based Behavioral Model of Health Care Utilization...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29780273/ectopic-ring-zinc-finger-gene-from-hot-pepper-induces-totally-different-genes-in-lettuce-and-tobacco
#12
Mahipal Singh Kesawat, Dong Kyun Kim, Naheed Zeba, Mi Chung Suh, Xinli Xia, Choo Bong Hong
Advances in molecular biology have improved crops through transferring genes from one organism to new hosts, and these efforts have raised concerns about potential unexpected outcomes. Here, we provide evidence that a gene with a specific function in one organism can yield completely different effects in a new host. CaRZFP1 is a C3HC4-type RING zinc finger protein gene previously isolated from a cDNA library for heat-stressed hot pepper. In our previous work investigating in vivo CaRZFP1 function, we transferred CaRZFP1 into tobacco; transgenic tobacco exhibited enhanced growth and tolerance to abiotic stresses...
2018: Molecular Breeding: New Strategies in Plant Improvement
https://www.readbyqxmd.com/read/29780024/the-neutrophil-mobilizing-cytokine-interleukin-26-in-the-airways-of-long-term-tobacco-smokers
#13
Karlhans Fru Che, Ellen Tufvesson, Sara Tengvall, Elisa Lappi-Blanco, Riitta Kaarteenaho, Bettina Levänen, Marie Ekberg, Annelie Brauner, Åsa M Wheelock, Leif Bjermer, C Magnus Sköld, Anders Lindén
Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26 (IL-26) is involved in airway inflammation amongst long-term tobacco smokers with or without COPD, chronic bronchitis or colonization by pathogenic bacteria...
May 23, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29779983/outcomes-of-a-randomized-trial-evaluating-two-approaches-for-promoting-pharmacy-based-referrals-to-the-tobacco-quitline
#14
Karen Suchanek Hudmon, Robin L Corelli, Carl de Moor, Alan J Zillich, Christine Fenlon, Lyndsay Miles, Alexander V Prokhorov, Susan M Zbikowski
OBJECTIVES: To evaluate the long-term impact of 2 promising intervention approaches to engage pharmacy personnel (pharmacists, technicians) in referring patients who want to quit smoking to the tobacco quitline. DESIGN: Randomized trial. SETTING: Community pharmacies in Connecticut (n = 32) and Washington (n = 32). INTERVENTION: Two intervention approaches were evaluated: academic detailing (AD), which involved on-site training for pharmacy staff about the quitline, versus mailed quitline materials (MM)...
May 17, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29779761/planting-the-seed-for-marijuana-use-changes-in-exposure-to-medical-marijuana-advertising-and-subsequent-adolescent-marijuana-use-cognitions-and-consequences-over-seven-years
#15
Elizabeth J D'Amico, Anthony Rodriguez, Joan S Tucker, Eric R Pedersen, Regina A Shih
BACKGROUND: Marijuana use during adolescence is associated with neurocognitive deficits and poorer functioning across several domains. It is likely that more states will pass both medical and recreational marijuana legalization laws in the coming elections; therefore, we must begin to look more closely at the longitudinal effects of medical marijuana (MM) advertising on marijuana use among adolescents so that we can better understand effects that this advertising may have on their subsequent marijuana use and related outcomes...
May 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29779515/health-care-of-sexual-minority-women
#16
REVIEW
Susan Jo Roberts
Sexual minority women may be invisible in health care settings unless practitioners ask every patient about sexual attractions/behaviors and identity. Sexual minority women need to feel comfortable and able to share information about their sexual identity, partners, and lives. No medical diagnoses are found more commonly in sexual minority women, but problems such as overweight/obesity, increased tobacco and alcohol use, increased mental health problems, and a past history of childhood sexual abuse are common...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29779494/not-so-sweet-refrain-sugar-sweetened-beverage-taxes-industry-opposition-and-harnessing-the-lessons-learned-from-tobacco-control-legal-challenges
#17
Anita George
As a growing number of countries implement, or announce plans to introduce, a sugar-sweetened beverage (SSB) tax, this paper explores the public health rationale for such a tax and provides an overview of the international normative and policy instruments supporting the introduction of fiscal measures on sugary drinks. After examining parallels between the legal arguments raised by the food and beverage industry in opposition to SSB taxes and those raised by the tobacco industry in response to tobacco control measures, this paper draws four key lessons that will assist countries to design effective and robust SSB tax measures and counter food and beverage industry opposition: regulatory distinctions in tax coverage should be based on bona fide, evidence-based reasoning; evidence-based measures need to be tailored to a country's public health objectives as part of a comprehensive strategy to address unhealthy diet consumption; procedural requirements and due process should be observed in the drafting and implementation of the measure; and regulatory space exists within domestic constitutions, laws and international trade and investment agreements recognising the sovereign right of states to regulate in the interests of public health...
May 21, 2018: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/29779198/redeveloping-substance-abuse-treatment-for-military-personnel
#18
REVIEW
Christian Schrader, Antoinette Lenton, Peter Gertonson, Alexander Rahimi
PURPOSE OF REVIEW: We review the prevailing evidence surrounding treatment of substance use disorder (SUD), with specific focus on alcohol, tobacco, and prescription opiates, and how it informs guidelines for treating active duty military. We survey the evidence regarding preventive screening, treatment, and relapse prevention in substance misuse as it pertains to patient-centered care of the service member. RECENT FINDINGS: Holistic, patient-centered care with an emphasis on identifying maladaptive use or dependence prior to progression to chronic disease is now recognized as the evidenced approach to treating substance use disorders...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29779094/-cell-grafting-a-new-approach-for-transferring-cytoplasmic-or-nuclear-genome-between-plants
#19
Vladimir Sidorov, Charles Armstrong, Thomas Ream, Xudong Ye, Annie Saltarikos
A new method based on mixing and wounding of callus tissue was used to transfer plastid or nuclear DNA between cells. Methods alternative to sexual hybridization can be powerful tools for crop improvement. We have developed a new hybridization technology based on wounding a mixed population of cells of two parents growing in vitro as callus ("cell grafting"), and have demonstrated the utility of this system for plastid or nuclear genome transfer. In our proof-of concept experiments, non-organized growing tissue (callus) from tobacco var...
May 19, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29779082/does-obesity-influence-the-risk-of-clostridium-difficile-infection-among-patients-with-ulcerative-colitis
#20
Sajiv Chandradas, Hamed Khalili, Ashwin Ananthakrishnan, Connor Wayman, Warren Reidel, Jill Waalen, Gauree G Konijeti
BACKGROUND: Patients with ulcerative colitis (UC) are at an increased risk of Clostridium difficile infection (CDI) compared with the general population. Recent data suggest that obesity also increases the risk of CDI. AIMS: To examine whether obesity influences the risk of CDI among patients with UC. STUDY: We conducted a retrospective cross-sectional study of UC patients seen in gastroenterology clinic between January 1, 2014, and December 31, 2015...
May 19, 2018: Digestive Diseases and Sciences
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