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https://www.readbyqxmd.com/read/28103571/identification-of-aurintricarboxylic-acid-as-a-selective-inhibitor-of-the-tweak-fn14-signaling-pathway-in-glioblastoma-cells
#1
Alison Roos, Harshil D Dhruv, Ian T Mathews, Landon J Inge, Serdar Tuncali, Lauren K Hartman, Donald Chow, Nghia Millard, Holly H Yin, Jean Kloss, Joseph C Loftus, Jeffrey A Winkles, Michael E Berens, Nhan L Tran
The survival of patients diagnosed with glioblastoma (GBM), the most deadly form of brain cancer, is compromised by the proclivity for local invasion into the surrounding normal brain, which prevents complete surgical resection and contributes to therapeutic resistance. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the transcription factor NF-κB...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28101491/can-the-american-thyroid-association-risk-of-recurrence-predict-radioiodine-refractory-disease-in-differentiated-thyroid-cancer
#2
Aamna Hassan, Saima Riaz, Humayun Bashir, M Khalid Nawaz, Raza Hussain
OBJECTIVE: The aim of this study was to compare the TNM staging system and the American Thyroid Association (ATA) recurrence risk classification in predicting radioiodine refractory disease (RRD) in differentiated thyroid cancer (DTC) and to analyze the correlation of stimulated thyroglobulin (Tg) levels and rate of Tg elevation with the standardized uptake value on (18)F-fludeoxyglucose (FDG) PET/CT scan. METHODS: RRD was indicated through the retrospective analysis of consecutive (18)F-FDG PET/CT scans in DTC with stimulated Tg >10 ng/ml and negative (131)I NaI whole-body scans (WBS)...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101454/vitamins-are-they-safe
#3
REVIEW
Hadi Hamishehkar, Farhad Ranjdoost, Parina Asgharian, Ata Mahmoodpoor, Sarvin Sanaie
The consumption of a daily multivitamin among people all over the world is dramatically increasing in recent years. Most of the people believe that if vitamins are not effective, at least they are safe. However, the long term health consequences of vitamins consumption are unknown. This study aimed to assess the side effects and possible harmful and detrimental properties of vitamins and to discuss whether vitamins can be used as safe health products or dietary supplements. We performed a MEDLINE/PubMed, EMBASE, Scopus and Google Scholar search and assessed reference lists of the included studies which were published from 1993 through 2015...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28092116/changes-in-thyroid-cancer-incidence-post-2009-american-thyroid-association-guidelines
#4
Lucy L Shi, Carol DeSantis, Ahmedin Jemal, Amy Y Chen
BACKGROUND: The thyroid cancer incidence rate has tripled in the United States since the 1980s, especially among women and small-sized tumors. This trend has been attributed to increased detection due to the availability of ultrasound and fine-needle aspiration technology. In 2009, the American Thyroid Association (ATA) released revisions to their guidelines for well-differentiated thyroid cancers. OBJECTIVE: To examine trends in thyroid cancer incidence rates by tumor size and gender following the 2009 ATA guideline revisions...
January 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28089974/cardiopulmonary-disease-development-in-anti-rna-polymerase-iii-positive-systemic-sclerosis-comparative-analyses-from-an-unselected-prospective-patient-cohort
#5
Anna-Maria Hoffmann-Vold, Øyvind Midtvedt, Anders H Tennøe, Torhild Garen, May Brit Lund, Trond M Aaløkken, Arne K Andreassen, Fadi Elhage, Cathrine Brunborg, Eli Taraldsrud, Øyvind Molberg
OBJECTIVE: Extensive skin disease and renal crisis are hallmarks of anti-RNA polymerase III (RNAP)-positive systemic sclerosis (SSc), while lung and heart involvement data are conflicting. Here, the aims were to perform time-course analyses of interstitial lung disease (ILD) and pulmonary hypertension (PH) in the RNAP subset of a prospective unselected SSc cohort and to use the other autoantibody subsets as comparators. METHODS: The study cohort included 279 patients with SSc from the observational Oslo University Hospital cohort with complete data on (1) SSc-related autoantibodies, (2) paired, serial analyses of lung function and fibrosis by computed tomography, and (3) PH verified by right heart catheterization...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28081173/effect-of-rifampin-on-thyroid-function-test-in-patients-on-levothyroxine-medication
#6
Hye In Kim, Tae Hyuk Kim, Hosu Kim, Young Nam Kim, Hye Won Jang, Jae Hoon Chung, Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Won-Jung Koh, Sun Wook Kim
BACKGROUND: Levothyroxine (LT4) and rifampin (RIF) are sometimes used together; however, no clinical studies have assessed the effects of these drugs on thyroid function or the need to adjust LT4 dose. METHODS: We retrospectively reviewed the records of 71 Korean patients who started RIF during LT4 treatment. Clinically relevant cases that required dose adjustment according to the American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) guidelines were identified, and risk factors of increased LT4 dose were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28077816/incidence-of-atrial-tachyarrhythmias-in-patients-with-early-repolarization-syndrome
#7
Ki Won Hwang, Gi-Byoung Nam, Junhee Han, Yong Giun Kim, Hyung Oh Choi, Jun Kim, Kee-Joon Choi, You-Ho Kim
Atrial tachyarrhythmias (ATAs) occur in a significant proportion of Brugada syndrome (BrS) patients and are often an important cause of inappropriate shocks. The aim of this retrospective study was to evaluate the incidence of ATAs and ATA-induced inappropriate shocks in early repolarization syndrome (ERS) patients as compared to BrS patients.We analyzed data from 20 consecutive patients who were diagnosed with ERS and compared them with patients diagnosed with BrS (n = 31). Clinical and ICD interrogation data were collected and analyzed for all events with ICD shocks...
January 11, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28070915/mitral-valve-resistance-determines-hemodynamic-consequences-of-severe-rheumatic-mitral-stenosis-and-immediate-outcomes-of-percutaneous-valvuloplasty
#8
Hamidreza Sanati, Reza Zolfaghari, Niloufar Samiei, Yousef Rezaei, Mitra Chitsazan, Ali Zahedmehr, Farshad Shakerian, Reza Kiani, Ata Firouzi, Reza Rezaei Tabrizi
INTRODUCTION: The mitral valve area (MVA) poorly reflects the hemodynamic status of (MS). In this study, we compared the MVA with mitral valve resistance (MVR) with regard to the determination of hemodynamic consequences of MS and the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV). METHODS: In a prospective study, 36 patients with severe rheumatic MS with left ventricular ejection fraction (LVEF) >50% were evaluated. They underwent transthoracic echocardiography (TTE) and catheterization...
January 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28065873/hyperbaric-oxygen-effects-on-depression-like-behavior-and-neuroinflammation-in-traumatic-brain-injury-rats
#9
Sher-Wei Lim, Kuan-Chin Sung, Yow-Ling Shiue, Che-Chuan Wang, Chung-Ching Chio, Jinn-Rung Kuo
OBJECTIVE: The aim of this study was to determine whether hyperbaric oxygen (HBO) therapy causes attenuation of traumatic brain injury (TBI)-induced depression-like behavior and its associated anti-neuroinflammatory effects after fluid percussion injury. METHODS: Anesthetized male Sprague-Dawley rats were divided into three groups: sham operation + NBA (normobaric air: 21% O2 at 1 absolute atmosphere [ATA]), TBI + NBA, and TBI + HBO (100% O2 at 2.0 ATA). HBO was applied immediately for 60 min/day after TBI for 3 days...
January 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28061455/enhancement-of-the-bioavailability-of-a-novel-anticancer-compound-acetyltanshinone-iia-by-encapsulation-within-mpeg-plga-nanoparticles-a-study-of-formulation-optimization-toxicity-and-pharmacokinetics
#10
Qi Wang, Na Wei, Xiaofeng Liu, Alex Chang, Kathy Qian Luo
The Poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (mPEG-PLGA) nanoparticles carrying acetyltanshinone IIA (ATA), a novel anti-breast cancer agent, were prepared by ultrasonic emulsion method to enhance the bioavailability and reduce the toxicity. Systematic optimization of encapsulation process was achieved using an orthogonal design. Drug efficacy analysis showed that ATA nanoparticles were as effective as free ATA against estrogen receptor positive breast cancer cells, but much less toxic towards human endothelial cells...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060389/choroidal-thickness-in-childhood-obesity
#11
Ayse Derya Bulus, Mehmet Erol Can, Ata Baytaroglu, Gamze Dereli Can, Hasan Basri Cakmak, Nesibe Andiran
BACKGROUND AND OBJECTIVE: To evaluate the effects of obesity on choroidal thickness (CT) in childhood. PATIENTS AND METHODS: Forty-four patients with obesity (study group) and 42 healthy children (control group) were enrolled in the study. Subjects underwent a complete ocular examination. The mean CT was measured by enhanced depth imaging optical coherence tomography (EDI-OCT). Body mass index (BMI) was calculated. RESULTS: Mean BMI value was 31...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28056690/2016-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum
#12
Erik K Alexander, Elizabeth N Pearce, Gregory A Brent, Rosalind S Brown, Herbert Chen, Chrysoula Dosiou, William Grobman, Peter Laurberg, John H Lazarus, Susan J Mandel, Robin Peeters, Scott Sullivan
BACKGROUND: Thyroid disease in pregnancy is a common clinical problem. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were first published in 2011, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid disease in women during pregnancy, preconception and the postpartum period...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28054268/optimizing-the-phosphorus-use-in-cotton-by-using-csm-cropgro-cotton-model-for-semi-arid-climate-of-vehari-punjab-pakistan
#13
Asad Amin, Wajid Nasim, Muhammad Mubeen, Muhammad Nadeem, Liaqat Ali, Hafiz Mohkum Hammad, Syeda Refat Sultana, Khawar Jabran, M Habib Ur Rehman, Shakeel Ahmad, Muhammad Awais, Atta Rasool, Shah Fahad, Shah Saud, Adnan Noor Shah, Zahid Ihsan, Shahzad Ali, Ali Ahsan Bajwa, Khalid Rehman Hakeem, Asif Ameen, Amanullah, Hafeez Ur Rehman, Fahad Alghabar, Ghulam Hussain Jatoi, Muhammad Akram, Aziz Khan, Faisal Islam, Syed Tahir Ata-Ul-Karim, Muhammad Ishaq Asif Rehmani, Sajid Hussain, Muhammad Razaq, Amin Fathi
Crop nutrient management is an essential component of any cropping system. With increasing concerns over environmental protection, improvement in fertilizer use efficiencies has become a prime goal in global agriculture system. Phosphorus (P) is one of the most important nutrients, and strategies are required to optimize its use in important arable crops like cotton (Gossypium hirsutum L.) that has great significance. Sustainable P use in crop production could significantly avoid environmental hazards resulting from over-P fertilization...
January 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28054212/assessing-posterior-ocular-structures-in-%C3%AE-thalassemia-minor
#14
Hasan Basri Arifoglu, Bekir Kucuk, Necati Duru, Orhan Altunel, Ahmet Gulhan, Mustafa Ozen, Bilal Aygun, Mustafa Atas
PURPOSE: The aim of this study was to investigate the effect of β-thalassemia minor on choroidal, macular, and peripapillary retinal nerve fiber layer thickness. METHODS: To form the sample, we recruited 40 patients with β-thalassemia minor and 44 healthy participants. We used spectral-domain optical coherence tomography to take all measurements of ocular thickness, as well as measured intraocular pressure, axial length, and central corneal thickness. We later analyzed correlations of hemoglobin levels with ocular parameters...
January 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28054188/predictive-factors-for-active-surveillance-of-subcentimeter-thyroid-nodules-with-highly-suspicious-us-features
#15
Hye Mi Gweon, Eun Ju Son, Jeong-Ah Kim, Ji Hyun Youk
PURPOSE: This study was designed to assess the outcomes of subcentimeter thyroid nodules with highly suspicious ultrasonography (US) features and to investigate the predictive factors associated with malignancy and aggressive biological behavior to determine appropriate candidate factors for active surveillance. METHODS: Between June 2011 and December 2013, 1866 subcentimeter thyroid nodules with highly suspicious US features that were subjected to US-guided fine needle aspiration and subsequent surgery or US follow-up of at least 2 years were evaluated...
January 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28038723/the-value-of-wrist-circumference-for-predicting-the-presence-of-coronary-artery-disease-and-metabolic-syndrome
#16
Shokoufeh Hajsadeghi, Ata Firouzi, Pouria Bahadoran, Morteza Hassanzadeh
BACKGROUND: Recently, the value of various structural body components have been proposed for predicting cardio-metabolic risk. The present study aimed to assess the wrist circumference (WrC) as an alternative measure for differentiating patients with CAD and METs from those without CAD and METs. METHODS: We studied 228 consecutive subjects who underwent coronary angiography. Those with and without evidence of coronary artery involvement at angiography were considered as the coronary artery disease (CAD) group (n=139) and the non-CAD group (n=89), respectively...
December 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/28034610/anterior-tibial-artery-pseudoaneurysm-due-to-interlocking-bolt-of-tibial-nail-a-case-report-and-review
#17
Nitesh Gahlot, Rajendra Kumar Kanojia
Vascular injuries associated with the tibial nailing have been reported in few case reports. We here report a unique case of anterior tibial artery (ATA) pseudoaneurysm caused by the second proximal coronal interlocking bolt. We found that the position of interlocking bolts on the nail brings them very close to the anatomical positions of arteries in leg. The reports of ATA injury by interlocking bolts highlight the need for reconsidering the nail design and screw hole positions.
December 26, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28032294/examination-of-the-role-of-nmda-and-gabaa-receptors-in-the-effects-of-hyperbaric-oxygen-on-striatal-dopamine-levels-in-rats
#18
C Lavoute, M Weiss, J J Risso, J C Rostain
Hyperbaric oxygen induced in rats a decrease in striatal dopamine levels. Such decrease could be a result of changes in glutamatergic and GABAergic controls of the dopaminergic neurons into the Substantia Nigra Pars Compacta. The aim of this study was to determine the role of gluatamatergic and Gama-Amino-Butyric-Acid neurotransmissions in this alteration. Dopamine-sensitive electrodes were implanted into the striatum under general anesthesia. After one week rest, awaked rats were exposed to oxygen-nitrogen mixture at a partial pressure of oxygen of 3 absolute atmospheres...
December 28, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/28029496/accuracy-of-the-estimation-of-dental-age-in-comparison-with-chronological-age-in-a-spanish-sample-of-2641-living-subjects-using-the-demirjian-and-nolla-methods
#19
María Melo, Javier Ata-Ali
Age estimation is an important procedure in forensic medicine and is carried out for a number of reasons. For living persons, age estimation is performed in order to assess whether a child has attained the age of criminal responsibility, in scenarios involving rape, kidnapping or marriage, in premature births, adoption procedures, illegal immigration, pediatric endocrine diseases and orthodontic malocclusion, as well as in circumstances in which the birth certificate is not available or the records are suspect...
October 12, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28028606/novelty-seeking-mediates-the-effect-of-drd3-variation-on-onset-age-of-amphetamine-dependence-in-han-chinese-population
#20
Shin-Chang Kuo, Yi-Wei Yeh, Chun-Yen Chen, Chang-Chih Huang, Tien-Yu Chen, Che-Hung Yen, Chih-Sung Liang, Pei-Shen Ho, Ru-Band Lu, San-Yuan Huang
The dopamine receptor D3 (DRD3) gene, one of the candidate genes for amphetamine dependence (AD), is involved in the mesolimbic dopaminergic system, implicated as the underlying mechanism of addiction. Our case-control study aimed to investigate whether the DRD3 gene is associated with the susceptibility to AD and specific personality traits in AD patients. A total of 1060 unrelated Han Chinese subjects (559 AD patients and 501 controls) were screened using the same assessment tool and genotyped for eight DRD3 polymorphisms...
December 27, 2016: European Archives of Psychiatry and Clinical Neuroscience
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