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Spinal glioblastoma

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https://www.readbyqxmd.com/read/28089804/multicentric-spinal-cord-glioblastoma
#1
Eibar Ernesto Cabrera-Aldana, Rafael De la Garza Ramos, Raúl Pichardo-Bahena
No abstract text is available yet for this article.
January 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28089418/distant-spread-of-a-supratentorial-glioblastoma-to-the-spinal-cord
#2
Krishnan Ravindran, Frank Gaillard, Arian Lasocki
Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28051009/spinal-metastases-of-glioblastoma-multiforme-in-a-patient-with-polyneuropathy
#3
Leslaw W Zub, Marta Waliszewska-Prosól, Tomasz Szczepañski, Zdzislaw Woÿniak, Maria Ejma
No abstract text is available yet for this article.
July 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28029927/regression-of-glioblastoma-after-chimeric-antigen-receptor-t-cell-therapy
#4
Christine E Brown, Darya Alizadeh, Renate Starr, Lihong Weng, Jamie R Wagner, Araceli Naranjo, Julie R Ostberg, M Suzette Blanchard, Julie Kilpatrick, Jennifer Simpson, Anita Kurien, Saul J Priceman, Xiuli Wang, Todd L Harshbarger, Massimo D'Apuzzo, Julie A Ressler, Michael C Jensen, Michael E Barish, Mike Chen, Jana Portnow, Stephen J Forman, Behnam Badie
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher...
29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27997032/k27m-midline-gliomas-display-malignant-progression-by-imaging-and-histology
#5
Franziska J Vettermann, Julia E Neumann, Bogdana Suchorska, Peter Bartenstein, Armin Giese, Mario M Dorostkar, Nathalie L Albert, Ulrich Schüller
K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV)...
December 20, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27951723/-a-patient-with-primary-intraventricular-gliosarcoma-and-long-term-survival-a-case-report
#6
O Kalita, M Zlevorová, M Megová, M Vaverka, R Trojanec, L Tučková
BACKGROUND: Gliosarcoma is a rare, malignant CNS tumor with a very poor prognosis. Gliosarcoma is a variant of glioblastoma multiforme, which is characterized by the presence of both glial and mesenchymal components. The treatment strategy for gliosarcomas has not yet been determined clearly. CASE PRESENTATION: This case report presents a 23-year-old female patient who complained of increasing headaches, nausea and vomiting, and slight motor weakness in her left arm...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27941618/aquaporins-in-the-spinal-cord
#7
REVIEW
Michal K Oklinski, Mariusz T Skowronski, Agnieszka Skowronska, Michael Rützler, Kirsten Nørgaard, John D Nieland, Tae-Hwan Kwon, Søren Nielsen
Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer's disease and Parkinson's disease...
December 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27813458/a-systematic-review-of-overall-survival-in-pediatric-primary-glioblastoma-multiforme-of-the-spinal-cord
#8
Subhas K Konar, Shyamal C Bir, Tanmoy K Maiti, Anil Nanda
OBJECTIVE The incidence of primary spinal cord glioblastoma multiforme (GBM) in the pediatric age group is very rare. Only a few case series and case reports have been published in the literature; therefore, overall survival (OS) outcome and the as-yet poorly defined management options are not discussed in detail. The authors performed a cumulative survival analysis of all reported cases of pediatric spinal cord GBM to identify the predictive factors related to final survival outcome. METHODS A comprehensive search for relevant articles was performed on PubMed's electronic database MEDLINE for the period from 1950 to 2015 using the search words "malignant spinal cord tumor" and "spinal glioblastoma multiforme...
November 4, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27806338/mir-143-suppresses-the-epithelial-mesenchymal-transition-of-spinal-glioblastoma-through-down-regulation-of-erk5
#9
Yi Yan, Jing Wu, Mingjun Wu, Yongzhi Xia, Wenyuan Tang, Zhengbu Liao
The spinal glioblastoma (GBM) represents the one of most common tumors in humans. However, the biological processes and molecular mechanisms of spinal GBM are still unclear. It is known that miR-143 participates in the development of various tumor progressions. The present study was to evaluate the level of miR-143 in spinal GBM tissues and cells. We further investigated that the molecular mechanisms of miR-143 in U87 and U251 cell lines. Here, our data showed that the expression levels of miR-143 were significantly reduced in spinal GBM tissues and cell lines...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27777151/management-of-patients-with-primary-intramedullary-spinal-cord-glioblastoma
#10
Bedjan Behmanesh, Matthias Setzer, Juergen Konczalla, Patrick Harter, Johanna Quick-Weller, Lioba Imoehl, Kea Franz, Florian Gessler, Volker Seifert, Gerhard Marquardt
BACKGROUND: Primary intramedullary spinal cord glioblastoma are very rare tumors of the spinal cord. They imply a very poor prognosis since complete surgical resection is not possible due to the infiltrative growth of these tumors. The aim of this study is to present our data achieved with an aggressive multimodality treatment. METHODS: We retrospectively reviewed our clinical database. All patients with histologically proven intramedullary spinal cord glioblastoma treated in our department were included in this study...
October 21, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27695566/a-case-of-symptomatic-synchronous-cervical-and-cerebellar-metastasis-after-resection-of-thoracal-metastasis-from-temporal-glioblastoma-multiforme-without-any-local-recurrence
#11
Yasar Karatas, Sahika Liva Cengiz, Mehmet Erkan Ustun
Glioblastoma multiforme (GBM) is the most common and the most malignant primary intracranial tumor in adults and it is usually occurs between the age of 40 and 60 years. It is local invasive and recurrent tumor and hence that has a poor prognosis. However, recent advances in tumor surgery, irradiation and chemotherapeutic agent permit long survival and metastasis which is symptomatic. Previously studies reported spinal metastasis, but we report a first case of synchronous symptomatic cerebellar and cervical spinal metastasis after resection of symptomatic thoracic spinal metastasis from temporal GBM without any recurrence of excision areas...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27683556/immunogenomics-of-hypermutated-glioblastoma-a-patient-with-germline-pole-deficiency-treated-with-checkpoint-blockade-immunotherapy
#12
Tanner M Johanns, Christopher A Miller, Ian G Dorward, Christina Tsien, Edward Chang, Arie Perry, Ravindra Uppaluri, Cole Ferguson, Robert E Schmidt, Sonika Dahiya, George Ansstas, Elaine R Mardis, Gavin P Dunn
: We present the case of a patient with a left frontal glioblastoma with primitive neuroectodermal tumor features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient developed a cervical spine metastasis and was subsequently treated with pembrolizumab. Shortly thereafter, the patient developed an additional metastatic spinal lesion. Using whole-exome DNA sequencing and clonal analysis, we report changes in the subclonal architecture throughout treatment...
November 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27549144/role-of-kca3-1-channels-in-cns-diseases-a-concise-review
#13
Sinoy Sugunan, Sreekala S Nampoothiri, Tanya Garg, Rajanikant G Krishnamurthy
KCa3.1 protein is part of a heterotetrameric voltage-independent potassium channel, the activity of which depends on the intracellular calcium binding to calmodulin. KCa3.1 is immensely significant in regulating immune responses and primarily expressed in cells of hematopoietic lineage. It is one of the attractive pharmacological targets that are known to inhibit neuroinflammation. KCa3.1 blockers mediate neuroprotection through multiple mechanisms, such as by targeting microglia-mediated neuronal killing. KCa3...
August 22, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27512613/multicentric-spinal-cord-and-brain-glioblastoma-without-previous-craniotomy
#14
Sayoa A de Eulate-Beramendi, Kelvin M Piña-Batista, Victor Rodrigo, Hector E Torres-Rivas, Juan C Rial-Basalo
BACKGROUND: Glioblastoma multiforme (GBS) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric gliomas lesions are widely separated in site and/or time and its incidence has been reported between 0.15 and 10%. Multicentric gliomas involving supratentorial and infratentorial region are even more rare. In most cases, infratentorial disease is seen after surgical manipulation or radiation therapy and is usually located in the cerebellum or cervical region...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27475832/the-multiple-faces-of-nervous-system-lymphoma-atypical-magnetic-resonance-imaging-features-and-contribution-of-the-advanced-imaging
#15
María Del Mar Jiménez de la Peña, Lidia Gómez Vicente, Raquel Cano Alonso, Silvia Fuertes Cabero, Antonio Maldonado Suárez, Vicente Martínez de Vega
Primary central nervous system lymphoma (PCNSL) is an uncommon variant of extranodal non-Hodgkin lymphoma, which involves the brain, leptomeninges, eyes, or spinal cord without evidence of systemic disease. In addition to a detailed history and physical examination, the evaluation of patients suspected of having a PCNSL should include a contrast-enhanced magnetic resonance imaging. Occassionaly, PCNSL shows peculiarities on magnetic resonance imaging, which delay the diagnosis and thus the start of treatment...
April 27, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/27438700/primary-spinal-glioblastoma-multiforme-with-cerebral-parenchymal-metastasis-in-a-child
#16
Panagiotis Kokkalis, Christos Chamilos, Spyros Sgouros
No abstract text is available yet for this article.
2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27423629/curcumin-alleviates-oxidative-stress-and-mitochondrial-dysfunction-in-astrocytes
#17
Amita Daverey, Sandeep K Agrawal
Oxidative stress plays a critical role in various neurodegenerative diseases, thus alleviating oxidative stress is a potential strategy for therapeutic intervention and/or prevention of neurodegenerative diseases. In the present study, alleviation of oxidative stress through curcumin is investigated in A172 (human glioblastoma cell line) and HA-sp (human astrocytes cell line derived from the spinal cord) astrocytes. H2O2 was used to induce oxidative stress in astrocytes (A172 and HA-sp). Data show that H2O2 induces activation of astrocytes in dose- and time-dependent manner as evident by increased expression of GFAP in A172 and HA-sp cells after 24 and 12h respectively...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27403775/rapid-neurological-recovery-following-partial-surgical-resection-of-spinal-glioblastoma-multiforme-in-a-pediatric-patient-presenting-with-complete-paraplegia
#18
Gabriel N Friedman, Benjamin L Grannan, Vijay Yanamadala, Ganesh M Shankar, John C Dewitt, Vidya Puthenpura, Robert M Koffie, Shannon M Macdonald, David H Ebb, Matthew P Frosch, Ann-Christine Duhaime
Pediatric spinal cord glioblastoma multiforme is a rare entity with a poor prognosis often presenting with lower extremity weakness or paralysis. Previous literature suggests that aggressive surgical resection may provide overall survival benefit; however, there is limited concurrent analysis demonstrating neurological recovery following surgical resection. We report the case of a 9-year-old boy who presented with complete paraplegia and regained the ability to ambulate independently following subtotal surgical resection, radiation, and chemotherapy...
November 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27401449/statistical-report-of-central-nervous-system-tumors-histologically-diagnosed-in-the-sichuan-province-of-china-from-2008-to-2013-a-west-china-glioma-center-report
#19
Xiang Wang, Jin-Xiu Chen, Qiao Zhou, Yan-Hui Liu, Qing Mao, Chao You, Ni Chen, Li Xiong, Jie Duan, Liang Liu
BACKGROUND: Sichuan is a province in the west of China with a population of 81.4 million. This is the first statistical report of central nervous system (CNS) tumors surgically treated and histologically diagnosed in a large Chinese population. METHODS: All the patient data were obtained from 86 medical facilities, which covered the Sichuan province population. Data from patients who underwent surgery between 2008 and 2013 and corresponding histology samples were re-reviewed in the major pathology centers...
December 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27348216/dynamic-regulation-of-rna-editing-in-human-brain-development-and-disease
#20
Taeyoung Hwang, Chul-Kee Park, Anthony K L Leung, Yuan Gao, Thomas M Hyde, Joel E Kleinman, Anandita Rajpurohit, Ran Tao, Joo Heon Shin, Daniel R Weinberger
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical development: stable high, stable low and increasing. RNA secondary structure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and trans-regulatory mechanisms of these RNA editing patterns, respectively...
August 2016: Nature Neuroscience
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