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Gliomatosis cerebri

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https://www.readbyqxmd.com/read/27836704/perioperative-risk-assessment-of-patients-with-gliomatosis-cerebri
#1
Nir Shimony, Ben Shofty, Zvi Ram, Rachel Grossman
BACKGROUND: Gliomatosis-cerebri (GC) is a rare diffusely infiltrating malignant glial neoplasm. Presenting symptoms may include seizures, neurological deficits, and not infrequently, symptoms related to increased intra-cranial pressure(ICP). Surgical intervention, including brain biopsy may induce worsening of these neurological symptoms. We reviewed our database to identify prognostic and risk factors for peri-operative deterioration specifically associated with elevated ICP. METHODS: Between 2006-2014 seventy-eight patients were treated for GC...
November 8, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27624914/antigen-specific-immunoreactivity-and-clinical-outcome-following-vaccination-with-glioma-associated-antigen-peptides-in-children-with-recurrent-high-grade-gliomas-results-of-a-pilot-study
#2
Ian F Pollack, Regina I Jakacki, Lisa H Butterfield, Ronald L Hamilton, Ashok Panigrahy, Daniel P Normolle, Angela K Connelly, Sharon Dibridge, Gary Mason, Theresa L Whiteside, Hideho Okada
Recurrent high-grade gliomas (HGGs) of childhood have an exceedingly poor prognosis with current therapies. Accordingly, new treatment approaches are needed. We initiated a pilot trial of vaccinations with peptide epitopes derived from glioma-associated antigens (GAAs) overexpressed in these tumors in HLA-A2+ children with recurrent HGG that had progressed after prior treatments. Peptide epitopes for three GAAs (EphA2, IL13Rα2, survivin), emulsified in Montanide-ISA-51, were administered subcutaneously adjacent to intramuscular injections of poly-ICLC every 3 weeks for 8 courses, followed by booster vaccines every 6 weeks...
September 13, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27598892/radiology-case-of-the-month-gliomatosis-cerebri
#3
Radia Ksayer, Jeremy B Nguyeni, Enrique Palacios, James Vu, Mandy Weidenhaft, Harold Neitzschman
A 71 year-old female with a past medical history significant for hypertension, hyperlipidemia, diabetes, and strokes, presented initially to the stroke service with a sudden onset of right facial droop, right-sided weakness, dysarthria, and seizures that had gotten progressively worse for six weeks.
July 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27466787/gliomatosis-cerebri-a-consensus-summary-report-from-the-first-international-gliomatosis-cerebri-group-meeting-march-26-27-2015-paris-france
#4
Jeffrey P Greenfield, Alicia Castañeda Heredia, Emilie George, Mark W Kieran, Andres Morales La Madrid
Gliomatosis cerebri (GC) is a universally fatal extensive and diffuse infiltration of brain parenchyma by a glial tumor. Many aspects of this phenomenon remain unknown. The First International Gliomatosis cerebri Group Meeting had the following goals: refine the clinical and radiologic diagnostic criteria for GC, suggest appropriate diagnostic procedures, standardize tissue manipulation for histologic and molecular characterization, and prioritize relevant preclinical projects. Also, general treatment recommendations were outlined for the pediatric population...
July 28, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27181462/nanostructured-lipid-carriers-solid-lipid-nanoparticles-and-polymeric-nanoparticles-which-kind-of-drug-delivery-system-is-better-for-glioblastoma-chemotherapy
#5
Jie Qu, Liangqiao Zhang, Zhihua Chen, Guohua Mao, Ziyun Gao, Xianliang Lai, Xingen Zhu, Jianming Zhu
CONTEXT: Glioblastoma is a malignant brain tumor originating in the central nervous system. Successfully therapy of this disease required the efficient delivery of therapeutic agents to the tumor cells and tissues. Delivery of anticancer drugs using novel nanocarriers is promising in glioma treatment. OBJECTIVE: Polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs) were constructed for the delivery of temozolomide (TMZ)...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27154542/epidermal-growth-factor-receptor-and-ki-67-expression-in-canine-gliomas
#6
A R Fraser, B Bacci, M A le Chevoir, S N Long
Novel therapies, including molecular targeted therapies, are being developed for the treatment of human gliomas. To use such therapies for canine gliomas, more complete characterization of molecular targets is required. Epidermal growth factor receptor (EGFR) is one such therapeutic target used in human glioma trials, and the Ki-67 labeling index (LI) is a marker of proliferation and a prognostic indicator. The objectives of this cross-sectional study were to evaluate the expression of EGFR and Ki-67 in canine gliomas and to determine if immunopositivity is associated with tumor type and histologic grade...
May 6, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27017609/msi-detection-and-its-pitfalls-in-cmmrd-syndrome-in-a-family-with-a-bi-allelic-mlh1-mutation
#7
Aurélia Nguyen, Gaelle Bougeard, Meriam Koob, Marie Pierre Chenard, Anne Schneider, Christine Maugard, Natacha Entz-Werle
The constitutional MisMatch Repair deficiency (CMMRD) syndrome is one of the inherited cancer predisposition syndromes. More than two-third patients belonging to a CMMRD family are diagnosed mainly in the first decade with brain cancers and/or hematological malignancies. This syndrome is due to bi-allelic germline mutations in genes of the MMR pathway (MLH1, MSH2, MSH6 or PMS2). Our family report begins with the index case presenting initially with a medulloblastoma, which was even the two relapses in complete remission, when she was diagnosed for an AML...
October 2016: Familial Cancer
https://www.readbyqxmd.com/read/27014538/advanced-imaging-for-biopsy-guidance-in-primary-brain-tumors
#8
Nelson Moussazadeh, Apostolos J Tsiouris, Rohan Ramakrishna
Accurate glioma sampling is required for diagnosis and establishing eligibility for relevant clinical trials. MR-based perfusion and spectroscopy sequences supplement conventional MR in noninvasively predicting the areas of highest tumor grade for biopsy. We report the case of a patient with gliomatosis cerebri and multifocal patchy enhancement in whom the combination of advanced and conventional imaging attributes successfully guided a diagnostic biopsy.
2016: Curēus
https://www.readbyqxmd.com/read/26962350/pediatric-gliomatosis-cerebri-mimicking-tubercular-encephalitis
#9
Namit Singhal, Vinay Agarwal
Gliomatosis cerebri (GC) is a diffuse infiltrating glial neoplasm of astrocytic origin. GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic myriad conditions. We discuss here the presentation and diagnosis of GC in a child who was initially treated on lines of tubercular encephalitis, with transient clinical relief and disappearance of enhancing component of the disease on magnetic resonance imaging. In this report, we highlight the limitations of clinical presentation and neuroimaging as well as the essential role of histological evaluation for the diagnosis of GC in children...
October 2015: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/26493382/gliomatosis-cerebri-no-evidence-for-a-separate-brain-tumor-entity
#10
Ulrich Herrlinger, David T W Jones, Martin Glas, Elke Hattingen, Dorothee Gramatzki, Moritz Stuplich, Jörg Felsberg, Oliver Bähr, Gerrit H Gielen, Matthias Simon, Dorothee Wiewrodt, Martin Schabet, Volker Hovestadt, David Capper, Joachim P Steinbach, Andreas von Deimling, Peter Lichter, Stefan M Pfister, Michael Weller, Guido Reifenberger
Gliomatosis cerebri (GC) is presently considered a distinct astrocytic glioma entity according to the WHO classification for CNS tumors. It is characterized by widespread, typically bilateral infiltration of the brain involving three or more lobes. Genetic studies of GC have to date been restricted to the analysis of individual glioma-associated genes, which revealed mutations in the isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 (TP53) genes in subsets of patients. Here, we report on a genome-wide analysis of DNA methylation and copy number aberrations in 25 GC patients...
February 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/26339959/epilepsy-surgery-related-to-pediatric-brain-tumors-miami-children-s-hospital-experience
#11
Aria Fallah, Alexander G Weil, Samir Sur, Ian Miller, Prasanna Jayakar, Glenn Morrison, Sanjiv Bhatia, John Ragheb
OBJECT: Pediatric brain tumors may be associated with medically intractable epilepsy for which surgery is indicated. The authors sought to evaluate the efficacy of epilepsy surgery for seizure control in pediatric patients with brain tumors. METHODS: The authors performed a retrospective review of consecutive patients undergoing resective epilepsy surgery related to pediatric brain tumors at Miami Children's Hospital between June 1986 and June 2014. Time-to-event analysis for seizure recurrence was performed; an "event" was defined as any seizures that occurred following resective epilepsy surgery, not including seizures and auras in the 1st postoperative week...
December 2015: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/26318497/gliomatosis-cerebri-with-spinal-metastasis-presenting-with-chronic-meningitis-in-two-boys
#12
Yi-Heng Lin, Yen-Wen Chang, Shih-Hung Yang, Hsiu-Hao Chang, Meng-Yao Lu, Pi-Chuan Fan
Spinal cord involvement in gliomatosis cerebri (GC) is uncommon. We report two patients with GC, who initially presented with chronic meningitis and were treated with antituberculous drugs. Although tumor meningitis was suspected, due to the intractable clinical course, a correct diagnosis was established after performing a biopsy examination of the metastatic spinal lesion which was detected by magnetic resonance imaging (MRI). Cerebrospinal fluid examination, including cytology, should be performed repetitively for patients with chronic meningitis refractory to antibiotic treatment...
September 2015: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/26239491/pediatric-gliomatosis-cerebri-a-review-of-15-years
#13
REVIEW
Emilie George, Allison Settler, Scott Connors, Jeffrey P Greenfield
Gliomatosis cerebri is a rare glial tumor that carries a poor prognosis. Seen in both adults and children, gliomatosis cerebri appears to differ in these populations as with adult versus pediatric glioblastoma. We present 10 children who either presented to the Weill Cornell Medical College or enrolled in the institution's Gliomatosis Cerebri International Registry alongside a cohort of 89 pediatric patients reported in the literature between 2000 and 2014. Age ranged from 4 months to 21 years, with a male to female ratio of 1...
March 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/26203691/vincristine-and-temozolomide-combined-chemotherapy-for-the-treatment-of-glioma-a-comparison-of-solid-lipid-nanoparticles-and-nanostructured-lipid-carriers-for-dual-drugs-delivery
#14
Miaojing Wu, Yanghua Fan, Shigang Lv, Bing Xiao, Minhua Ye, Xingen Zhu
CONTEXT: Glioma is a common malignant brain tumor originating in the central nervous system. Efficient delivery of therapeutic agents to the cells and tissues is a difficult challenge. Co-delivery of anticancer drugs into the cancer cells or tissues by multifunctional nanocarriers may provide a new paradigm in cancer treatment. OBJECTIVE: In this study, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were constructed for co-delivery of vincristine (VCR) and temozolomide (TMZ) to develop the synergetic therapeutic action of the two drugs...
October 2016: Drug Delivery
https://www.readbyqxmd.com/read/26203687/novel-rgd-containing-temozolomide-loading-nanostructured-lipid-carriers-for-glioblastoma-multiforme-chemotherapy
#15
Shuxin Song, Guohua Mao, Jiansheng Du, Xingen Zhu
CONTEXT: Glioblastoma multiforme (GBM) is the most common malignant brain tumor originating in the central nervous system. Efficient delivery of therapeutic molecules to the cells and tissues is a difficult challenge. OBJECTIVE: Arginine-glycine-aspartic acid peptide (RGD)-modified nanostructured lipid carriers (NLCs) were used for the delivery of temozolomide (TMZ) into the GBM to provide a new paradigm in gliomatosis cerebri treatment. METHODS: RGD-conjugated polyethylene glycol-b-distearoylphosphatidylethanolamine (PEG-DSPE) was synthesized...
May 2016: Drug Delivery
https://www.readbyqxmd.com/read/26017099/nanostructured-lipid-carriers-based-temozolomide-and-gene-co-encapsulated-nanomedicine-for-gliomatosis-cerebri-combination-therapy
#16
Zhihua Chen, Xianliang Lai, Shuxin Song, Xingen Zhu, Jianming Zhu
BACKGROUND: Co-delivery of gene and anticancer drug into the same cancer cells or tissues by multifunctional nanocarriers may provide a new paradigm in cancer treatment. In this study, nanostructured lipid carriers (NLCs) were constructed as multifunctional nanomedicine for co-delivery of enhanced green fluorescence protein plasmid (DNA) and temozolomide (TMZ). METHODS: TMZ- and DNA-loaded NLCs (TMZ/DNA-NLCs) were prepared. Their particle size, zeta potential, gene-loading capacity (GL) and drug encapsulation efficiency (EE) were evaluated...
May 2016: Drug Delivery
https://www.readbyqxmd.com/read/25997888/gliomatosis-cerebri-in-l-2-hydroxyglutaric-aciduria
#17
LETTER
Frédéric London, A Jeanjean
No abstract text is available yet for this article.
December 2015: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/25922538/corticosteroid-sensitivity-in-gliomatosis-cerebri-delays-diagnosis
#18
Jan Bittar, Carlos Kamiya-Matsuoka, Pedro C Barata, Soo-Hyun Lee-Kim, Adriana Olar, Ivo W Tremont-Lukats
No abstract text is available yet for this article.
August 2015: Practical Neurology
https://www.readbyqxmd.com/read/25662824/gliomatosis-cerebri-in-a-12-year-old-patient
#19
Young Ah Lee, William Kupsky, Deniz Altinok, Zhihong Joanne Wang, Lalitha Sivaswamy
No abstract text is available yet for this article.
April 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/25589818/gliomatosis-cerebri-mimicking-encephalitis-evaluated-using-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#20
Koramadai Karuppusamy Kamaleshwaran, Vijayan Krishnan, Vyshakh Mohanan, Deepu Shibu, Ajit Sugunan Shinto
Gliomatosis cerebri (GC) is a rare condition in which an infiltrative glial neoplasm spreads through the brain with preservation of the underlying structure. F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has an important role in demonstrating the appropriate metabolism and differentiating pathologies mimicking GC on CT and magnetic resonance imaging. We describe imaging findings of FDG PET/CT in GC in a 9-year-old male child mimicking encephalitis.
January 2015: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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