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Gliomatosis

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https://www.readbyqxmd.com/read/28539209/gliomatosis-cerebri-prognosis-based-on-current-molecular-markers
#1
REVIEW
Monish M Maharaj, Kevin Phan, Joshua Xu, Jacob Fairhall, Rajesh Reddy, Prashanth J V Rao
This study aims to review the literature and identify key molecular markers affecting the prognosis of Gliomatosis cerebri (2) to evaluate the level of evidence and identify outstanding markers requiring further study. A literature search was conducted across 5 major databases using the key terms: "Molecular markers" AND "Gliomatosis cerebri" OR "diffuse astrocytoma." Critical appraisal and data presentation was performed inline with the PRISMA guidelines. Following search strategy implementation, 11 studies were included in the final review process...
May 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28516072/bevacizumab-in-recurrent-glioma-patterns-of-treatment-failure-and-implications
#2
REVIEW
Yi Li, Saad Ali, Jennifer Clarke, Soonmee Cha
Glioblastoma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Bevacizumab, a monoclonal antibody against the vascular endothelial growth factor receptor, has increasingly been used in the treatment of recurrent glioblastoma. It has achieved excellent rates of radiographic response, but most patients will progress after only a few months. Upon recurrence, tumors may not enhance, secondary to vascular normalization. We describe four patterns of radiographic progression commonly associated with Bevacizumab failure: 1) Distant enhancing tumor, 2) Local tumor progression without enhancement, 3) Diffuse gliomatosis-like infiltration, and 4) Local or multifocal progression, with enhancement...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28486262/an-adolescent-presenting-with-seizures-as-a-symptom-of-gliomatosis-cerebri
#3
Elena Blanco-Iglesias, Beatriz Cabeza, Elena Garcia Esparza, Inmaculada de Prada, Alvaro Lassaletta, Marcelo Budke, Ana Serrano
Gliomatosis cerebri is a diffuse infiltrating glioma of neuroepithelial origin that affects more than 2 cerebral lobes. This is rarely seen in pediatric patients. The clinical presentation and imaging are very unspecific, and a biopsy is typically needed for the diagnosis. Given the widespread nature of the disease, surgical treatment is not possible and has a poor overall prognosis. A pediatric patient presented with elevated intracranial pressure. All initial studies were negative, and the imaging showed a symmetrical affection involving the supratentorial and infratentorial regions...
May 8, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28484570/gliomatosis-cerebri-in-a-10-year-old-male-patient
#4
Atahualpa Strapasson, Ápio Cláudio Martins Antunes, Francine Oliveira, Paulo P Oppitz
No abstract text is available yet for this article.
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28447171/prevalence-and-clinicopathological-features-of-h3-3-g34-mutant-high-grade-gliomas-a-retrospective-study-of-411-consecutive-glioma-cases-in-a-single-institution
#5
Koji Yoshimoto, Ryusuke Hatae, Yuhei Sangatsuda, Satoshi O Suzuki, Nobuhiro Hata, Yojiro Akagi, Daisuke Kuga, Murata Hideki, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara
A recurrent glycine-to-arginine/valine alteration at codon 34 (G34R/V) within H3F3A, a gene that encodes the replication-independent histone variant H3.3, reportedly occurs exclusively in pediatric glioblastomas. However, the clinicopathological and biological significances of this mutation have not been completely elucidated; especially, no such data exist for tumor samples from Japanese patients. We analyzed 411 consecutive glioma cases representing patients of all ages. Our results demonstrated that 14 patients (3...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28393096/18f-fdg-positron-emission-tomography-findings-of-gliomatosis-peritonei-a-case-report-and-review-of-the-literature
#6
J-M Lavoie, F Lacroix-Poisson, L N Hoang, D C Wilson, M J Seckl, A V Tinker
•Gliomatosis peritonei (GP) is a rare benign complication of ovarian teratomas that does not impact overall survival.•GP exhibits high 18-F FDG uptake unlike other non-malignant forms of mature teratoma.•The specific characteristics of GP on functional imaging may be used to follow it with active surveillance in select cases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28366748/management-and-survival-patterns-of-patients-with-gliomatosis-cerebri-a-seer-based-analysis
#7
Kate T Carroll, Brian Hirshman, Mir Amaan Ali, Ali A Alattar, Michael G Brandel, Bryson Lochte, Tyler Lanman, Bob Carter, Clark C Chen
OBJECTIVE: We used the SEER (Surveillance Epidemiology and End Results) database (1999-2010) to analyze the clinical practice patterns and overall survival in patients with gliomatosis cerebri (GC), or glioma involving 3 or more lobes of the cerebrum. METHODS: We identified 111 patients (age ≥18 years) with clinically or microscopically diagnosed GC in the SEER database. Analyses were performed to determine clinical practice patterns for these patients and whether these practices were associated with survival...
July 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28353668/bevacizumab-for-patients-with-recurrent-gliomas-presenting-with-a-gliomatosis-cerebri-growth-pattern
#8
Michael C Burger, Iris C Mildenberger, Marlies Wagner, Michel Mittelbronn, Joachim P Steinbach, Oliver Bähr
Bevacizumab has been shown to improve progression-free survival and neurologic function, but failed to improve overall survival in newly diagnosed glioblastoma and at first recurrence. Nonetheless, bevacizumab is widely used in patients with recurrent glioma. However, its use in patients with gliomas showing a gliomatosis cerebri growth pattern is contentious. Due to the marked diffuse and infiltrative growth with less angiogenic tumor growth, it may appear questionable whether bevacizumab can have a therapeutic effect in those patients...
March 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332472/primary-diffuse-leptomeningeal-gliomatosis-do-we-miss-the-diagnosis
#9
Sébastien Lepreux, Sharmilla Sagnier, Jean-Thomas Perez, François Léger, Igor Sibon, Anne Vital
Primary diffuse leptomeningeal gliomatosis (PDLG) is characterized by diffuse infiltration of the leptomeningeal space by neoplastic glial cells without evidence of intra-parenchymatous primary tumor. We report a case of PDLG in a 68-year-old man, who died 1 month after onset of symptoms. The diagnosis was made on autopsy data. We discuss the particularities of this entity, which is not registered in the WHO classification of tumors of the central nervous system (2016). In case of an unexplained inflammatory meningeal process and in the presence of atypical cells in the cerebrospinal fluid, PDLG needs to be considered...
March 23, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28219644/the-usefulness-of-18f-fluorocholine-pet-ct-in-the-detection-of-recurrence-of-central-nervous-system-primary-neoplasms
#10
A Montes, A Fernández, V Camacho, C de Quintana, O Gallego, J Craven-Bartle, D López, J Molet, B Gómez-Ansón, I Carrió
AIM: To study the usefulness of (18)F-fluorocholine (FCH) in detecting the recurrence of primary brain tumours. MATERIAL AND METHODS: A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumour. The distribution by pathology was: three grade ii astrocytomas, three grade iii astrocytomas, one grade ii oligodendroglioma, three grade iii oligodendrogliomas, one grade iii oligoastrocytoma, four glioblastoma multiform, one gliomatosis cerebri, and five meningiomas...
July 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28156189/feline-glioma-a-retrospective-study-and-review-of-the-literature
#11
Daniel R Rissi, Andrew D Miller
Case series summary This study aimed to evaluate the pathologic and diagnostic features of 13 cases of feline glioma diagnosed at two veterinary diagnostic institutions over 16 years. A retrospective search was conducted using the laboratory information system. Selected cases were reviewed, tumors were classified according to the 2007 World Health Organization Classification of Tumours of the Central Nervous System, and tissue sections were submitted to an immunohistochemistry panel for further characterization...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28126976/-gliomatosis-cerebri-as-a-clinical-entity
#12
Kazuhiko Sugiyama
Gliomatosis cerebri is a rare subtype of glioma involving more than three lobes of the central nervous system. Currently, diagnosis of gliomatosis cerebri can be confirmed pathologically, surgically, or with magnetic resonance imaging that shows high-signal areas expanding to the cerebral hemisphere, brain stem, cerebellum, and spinal cord. Although this disease has great clinical importance, it has recently been removed from the revised WHO classification of Tumors of the Central Nervous System (2016) owing to divergence between its morphological features and molecular profiles...
January 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28074710/canine-spinal-cord-glioma
#13
Daniel R Rissi, Renee Barber, Annabelle Burnum, Andrew D Miller
Spinal cord glioma is uncommonly reported in dogs. We describe the clinicopathologic and diagnostic features of 7 cases of canine spinal cord glioma and briefly review the veterinary literature on this topic. The median age at presentation was 7.2 y. Six females and 1 male were affected and 4 dogs were brachycephalic. The clinical course lasted from 3 d to 12 wk, and clinical signs were progressive and associated with multiple suspected neuroanatomic locations in the spinal cord. Magnetic resonance imaging of 6 cases revealed T2-weighted hyperintense lesions with variable contrast enhancement in the spinal cord...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28074323/changes-in-cerebral-metabolism-during-ketogenic-diet-in-patients-with-primary-brain-tumors-1-h-mrs-study
#14
Moran Artzi, Gilad Liberman, Nachum Vaisman, Felix Bokstein, Faina Vitinshtein, Orna Aizenstein, Dafna Ben Bashat
Normal brain cells depend on glucose metabolism, yet they have the flexibility to switch to the usage of ketone bodies during caloric restriction. In contrast, tumor cells lack genomic and metabolic flexibility and are largely dependent on glucose. Ketogenic-diet (KD) was suggested as a therapeutic option for malignant brain cancer. This study aimed to detect metabolic brain changes in patients with malignant brain gliomas on KD using proton magnetic-resonance-spectroscopy ((1)H-MRS). Fifty MR scans were performed longitudinally in nine patients: four patients with recurrent glioblastoma (GB) treated with KD in addition to bevacizumab; one patient with gliomatosis-cerebri treated with KD only; and four patients with recurrent GB who did not receive KD...
April 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27891270/primary-diffuse-leptomeningeal-gliomatosis-radiological-pathological-features
#15
Ehtasham Ahmad, Mohamed Mohamed, Apostolos Vrettos
We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27836704/perioperative-risk-assessment-of-patients-with-gliomatosis-cerebri
#16
Nir Shimony, Ben Shofty, Zvi Ram, Rachel Grossman
BACKGROUND: Gliomatosis cerebri is a rare diffusely infiltrating malignant glial neoplasm. Presenting symptoms include seizures, neurologic deficits, and frequently symptoms related to increased intracranial pressure (ICP). Surgical intervention, including brain biopsy, may induce worsening of these neurologic symptoms. We reviewed our database to identify prognostic and risk factors for perioperative deterioration specifically associated with elevated ICP. METHODS: Between 2006 and 2014, 78 patients were treated for gliomatosis cerebri...
February 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27636886/mature-and-immature-solid-teratomas-involving-uterine-corpus-cervix-and-ovary
#17
Simona Stolnicu, Emoke Szekely, Calin Molnar, Claudiu V Molnar, Iulia Barsan, Valeria D'Alfonso, Cosmin Moldovan, Gang Zheng, Brigitte M Ronnett, Robert A Soslow
Extragonadal teratomas are rare, and localization in the endometrium and cervix is exceptional, with fewer than 10 case reports documented so far in the English literature. We report here the case of a 46-year-old patient who presented with simultaneous immature teratoma in the endometrium and mature teratomas in the ovary in association with gliomatosis peritonei but with no evidence of gestational origin; she subsequently developed multiple solid mature teratomas in the cervix and parauterine tissue. No other similar cases have been previously reported to our knowledge...
September 15, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27624914/antigen-specific-immunoreactivity-and-clinical-outcome-following-vaccination-with-glioma-associated-antigen-peptides-in-children-with-recurrent-high-grade-gliomas-results-of-a-pilot-study
#18
Ian F Pollack, Regina I Jakacki, Lisa H Butterfield, Ronald L Hamilton, Ashok Panigrahy, Daniel P Normolle, Angela K Connelly, Sharon Dibridge, Gary Mason, Theresa L Whiteside, Hideho Okada
Recurrent high-grade gliomas (HGGs) of childhood have an exceedingly poor prognosis with current therapies. Accordingly, new treatment approaches are needed. We initiated a pilot trial of vaccinations with peptide epitopes derived from glioma-associated antigens (GAAs) overexpressed in these tumors in HLA-A2+ children with recurrent HGG that had progressed after prior treatments. Peptide epitopes for three GAAs (EphA2, IL13Rα2, survivin), emulsified in Montanide-ISA-51, were administered subcutaneously adjacent to intramuscular injections of poly-ICLC every 3 weeks for 8 courses, followed by booster vaccines every 6 weeks...
December 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27602142/gliomatosis-peritonei-with-bilateral-ovarian-teratomas-a-report-of-two-cases
#19
Jiawei Wang, Jingjing Xu, Minming Zhang, Baizhou Li
Gliomatosis peritonei (GP) is characterized by the presence of benign, mature neuroglial implants throughout the peritoneum and is typically accompanied by mature or immature ovarian teratomas. GP is a condition that has only been described relatively recently, with ~100 cases reported in the English literature. The majority of reported cases have focused on the pathology and clinical treatment of the disease; radiological findings are distinct, but the discussion of this is scarce in the literature. The current study presents two cases of GP with bilateral ovarian teratomas and provides a review of the relevant literature, with particular emphasis on the radiological differential diagnosis...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27598892/radiology-case-of-the-month-gliomatosis-cerebri
#20
Radia Ksayer, Jeremy B Nguyeni, Enrique Palacios, James Vu, Mandy Weidenhaft, Harold Neitzschman
A 71 year-old female with a past medical history significant for hypertension, hyperlipidemia, diabetes, and strokes, presented initially to the stroke service with a sudden onset of right facial droop, right-sided weakness, dysarthria, and seizures that had gotten progressively worse for six weeks.
July 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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