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https://www.readbyqxmd.com/read/29133710/role-of-preoperative-imaging-in-the-diagnosis-of-primary-diffuse-craniospinal-leptomeningeal-gliomatosis
#1
Jayant Vishal, Rana Patir, Sunita Ahlawat, Rakesh K Gupta
We present an unusual case of primary diffuse craniospinal leptomeningeal gliomatosis (PGDL), who was initially diagnosed on the basis of imaging, laboratory findings, and cranial meningeal biopsy as tuberculous meningitis and showed clinical deterioration while on anti-tuberculous treatment for 2 months. The patient was subsequently correctly diagnosed on diffusion weighted and post-contrast T1-weighted imaging of the craniospinal axis along with whole body imaging. The radiological findings were confirmed on histopathology and immunohistochemistry performed from the previous block as well as biopsy from the nodular mass in the lumbosacral meninges...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29110365/magnetic-resonance-imaging-features-of-canine-gliomatosis-cerebri
#2
Daniela Schweizer-Gorgas, Diana Henke, Anna Oevermann, Johann Lang, Marc Vandevelde, Frank Steffen
A retrospective, case series study was undertaken to identify magnetic resonance imaging (MRI) characteristics of gliomatosis cerebri in dogs. Fourteen dogs were included by review of histopathological records and contemporaneous MRI. On MRI, all lesions presented as ill-defined, intraaxial lesions within the left and right forebrain hemispheres with involvement of white and gray matter. Lesions presented as hyperintense areas on T2-weighted and FLAIR sequences and as hypointense or isointense areas on T1-weighted images, with mild parenchymal contrast enhancement in three dogs...
November 6, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29062809/parenchymal-infiltration-in-primary-diffuse-leptomeningeal-gliomatosis-dynamic-changes-in-brain-mri
#3
Yun Jiang, Juan Chen, Jing He, Ao Pei, Jinsong Zhang, Yinhong Liu
Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease with no special clinical manifestations. Here, we report the dynamic brain magnetic resonance imaging (MRI) changes in a 30-year-old female PDLG patient over a 10-month period. MRI showed aggressive dilation of the subarachnoid space and the ventricular system, numerous encapsulated cysts in the subarachnoid space and the dilated cerebral sulci, diffuse reticulated or focal nodular enhancement in the subarachnoid space, as well as overall enhancement in the cystic walls...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29028423/2016-updates-to-the-who-brain-tumor-classification-system-what-the-radiologist-needs-to-know
#4
Derek R Johnson, Julie B Guerin, Caterina Giannini, Jonathan M Morris, Lawrence J Eckel, Timothy J Kaufmann
Radiologists play a key role in brain tumor diagnosis and management and must stay abreast of developments in the field to advance patient care and communicate with other health care providers. In 2016, the World Health Organization (WHO) released an update to its brain tumor classification system that included numerous significant changes. Several previously recognized brain tumor diagnoses, such as oligoastrocytoma, primitive neuroectodermal tumor, and gliomatosis cerebri, were redefined or eliminated altogether...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28900469/necrotic-ulcerated-and-bleeding-striae-distensae-following-bevacizumab-in-a-palliative-setting-for-gliobastomatosis-cerebri
#5
Olivia Laugier, Laetitia Padovani, Arnauld Verschuur, Caroline Gaudy-Marqueste, Nicolas André
Glioblastoma cerebri is a rare paediatric malignancy with dismal prognosis [Chappé C, Riffaud L, and Tréguier C et al (2013) Primary gliomatosis cerebri involving gray matter in pediatrics: a distinct entity? A multicenter study of 14 casesChilds Nerv Syst29 565-571 https://doi.org/10.1007/s00381-012-2016-1 PMID: 23306961] and no established standard of care. Here, we report a case of ulcerated and bleeding striae distensae in a teenage girl following palliative treatment with bevacizumab and steroids.
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28837843/positive-influence-of-partial-resection-on-overall-survival-of-patients-with-overlapping-glioblastomas
#6
Johanna Quick-Weller, Stephanie Tritt, Peter Baumgarten, Jürgen Konczalla, Sepide Kashefiolasl, Anika Noack, Julia Tichy, Volker Seifert, Gerhard Marquardt
OBJECTIVES: Patients with overlapping glioblastomas (former known as gliomatosis cerebri according to the 2007 WHO classification) have a poor prognosis. Most of the patients undergo biopsy to confirm histopathological diagnosis. Treatment comprises chemotherapy, radiation and combination of both. We determined whether resection of the contrast enhancing tumor parts leads to a prolonged survival. PATIENTS AND METHODS: We performed a retrospective analysis and included 31 patients with overlapping glioblastomas (OG) who showed WHO IV in the initial histopathological examination...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28815663/who-2016-classification-of-gliomas
#7
Pieter Wesseling, David Capper
Gliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern ('non-diffuse gliomas'). In the revised 4th edition of the WHO Classification of CNS tumors published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion. Following this approach, the diagnosis of (anaplastic) oligoastrocytoma can be expected to largely disappear...
August 16, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28539209/gliomatosis-cerebri-prognosis-based-on-current-molecular-markers
#8
REVIEW
Monish M Maharaj, Kevin Phan, Joshua Xu, Jacob Fairhall, Rajesh Reddy, Prashanth J V Rao
This study aims to review the literature and identify key molecular markers affecting the prognosis of Gliomatosis cerebri (2) to evaluate the level of evidence and identify outstanding markers requiring further study. A literature search was conducted across 5 major databases using the key terms: "Molecular markers" AND "Gliomatosis cerebri" OR "diffuse astrocytoma." Critical appraisal and data presentation was performed inline with the PRISMA guidelines. Following search strategy implementation, 11 studies were included in the final review process...
September 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28516072/bevacizumab-in-recurrent-glioma-patterns-of-treatment-failure-and-implications
#9
REVIEW
Yi Li, Saad Ali, Jennifer Clarke, Soonmee Cha
Glioblastoma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Bevacizumab, a monoclonal antibody against the vascular endothelial growth factor receptor, has increasingly been used in the treatment of recurrent glioblastoma. It has achieved excellent rates of radiographic response, but most patients will progress after only a few months. Upon recurrence, tumors may not enhance, secondary to vascular normalization. We describe four patterns of radiographic progression commonly associated with Bevacizumab failure: 1) Distant enhancing tumor, 2) Local tumor progression without enhancement, 3) Diffuse gliomatosis-like infiltration, and 4) Local or multifocal progression, with enhancement...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28486262/an-adolescent-presenting-with-seizures-as-a-symptom-of-gliomatosis-cerebri
#10
Elena Blanco-Iglesias, Beatriz Cabeza, Elena Garcia Esparza, Inmaculada de Prada, Alvaro Lassaletta, Marcelo Budke, Ana Serrano
Gliomatosis cerebri is a diffuse infiltrating glioma of neuroepithelial origin that affects more than 2 cerebral lobes. This is rarely seen in pediatric patients. The clinical presentation and imaging are very unspecific, and a biopsy is typically needed for the diagnosis. Given the widespread nature of the disease, surgical treatment is not possible and has a poor overall prognosis. A pediatric patient presented with elevated intracranial pressure. All initial studies were negative, and the imaging showed a symmetrical affection involving the supratentorial and infratentorial regions...
May 8, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28484570/gliomatosis-cerebri-in-a-10-year-old-male-patient
#11
Atahualpa Strapasson, Ápio Cláudio Martins Antunes, Francine Oliveira, Paulo P Oppitz
No abstract text is available yet for this article.
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28447171/prevalence-and-clinicopathological-features-of-h3-3-g34-mutant-high-grade-gliomas-a-retrospective-study-of-411-consecutive-glioma-cases-in-a-single-institution
#12
Koji Yoshimoto, Ryusuke Hatae, Yuhei Sangatsuda, Satoshi O Suzuki, Nobuhiro Hata, Yojiro Akagi, Daisuke Kuga, Murata Hideki, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara
A recurrent glycine-to-arginine/valine alteration at codon 34 (G34R/V) within H3F3A, a gene that encodes the replication-independent histone variant H3.3, reportedly occurs exclusively in pediatric glioblastomas. However, the clinicopathological and biological significances of this mutation have not been completely elucidated; especially, no such data exist for tumor samples from Japanese patients. We analyzed 411 consecutive glioma cases representing patients of all ages. Our results demonstrated that 14 patients (3...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28393096/18f-fdg-positron-emission-tomography-findings-of-gliomatosis-peritonei-a-case-report-and-review-of-the-literature
#13
J-M Lavoie, F Lacroix-Poisson, L N Hoang, D C Wilson, M J Seckl, A V Tinker
•Gliomatosis peritonei (GP) is a rare benign complication of ovarian teratomas that does not impact overall survival.•GP exhibits high 18-F FDG uptake unlike other non-malignant forms of mature teratoma.•The specific characteristics of GP on functional imaging may be used to follow it with active surveillance in select cases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28366748/management-and-survival-patterns-of-patients-with-gliomatosis-cerebri-a-seer-based-analysis
#14
Kate T Carroll, Brian Hirshman, Mir Amaan Ali, Ali A Alattar, Michael G Brandel, Bryson Lochte, Tyler Lanman, Bob Carter, Clark C Chen
OBJECTIVE: We used the SEER (Surveillance Epidemiology and End Results) database (1999-2010) to analyze the clinical practice patterns and overall survival in patients with gliomatosis cerebri (GC), or glioma involving 3 or more lobes of the cerebrum. METHODS: We identified 111 patients (age ≥18 years) with clinically or microscopically diagnosed GC in the SEER database. Analyses were performed to determine clinical practice patterns for these patients and whether these practices were associated with survival...
July 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28353668/bevacizumab-for-patients-with-recurrent-gliomas-presenting-with-a-gliomatosis-cerebri-growth-pattern
#15
Michael C Burger, Iris C Mildenberger, Marlies Wagner, Michel Mittelbronn, Joachim P Steinbach, Oliver Bähr
Bevacizumab has been shown to improve progression-free survival and neurologic function, but failed to improve overall survival in newly diagnosed glioblastoma and at first recurrence. Nonetheless, bevacizumab is widely used in patients with recurrent glioma. However, its use in patients with gliomas showing a gliomatosis cerebri growth pattern is contentious. Due to the marked diffuse and infiltrative growth with less angiogenic tumor growth, it may appear questionable whether bevacizumab can have a therapeutic effect in those patients...
March 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332472/primary-diffuse-leptomeningeal-gliomatosis-do-we-miss-the-diagnosis
#16
Sébastien Lepreux, Sharmilla Sagnier, Jean-Thomas Perez, François Léger, Igor Sibon, Anne Vital
Primary diffuse leptomeningeal gliomatosis (PDLG) is characterized by diffuse infiltration of the leptomeningeal space by neoplastic glial cells without evidence of intra-parenchymatous primary tumor. We report a case of PDLG in a 68-year-old man, who died 1 month after onset of symptoms. The diagnosis was made on autopsy data. We discuss the particularities of this entity, which is not registered in the WHO classification of tumors of the central nervous system (2016). In case of an unexplained inflammatory meningeal process and in the presence of atypical cells in the cerebrospinal fluid, PDLG needs to be considered...
March 23, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28219644/the-usefulness-of-18f-fluorocholine-pet-ct-in-the-detection-of-recurrence-of-central-nervous-system-primary-neoplasms
#17
A Montes, A Fernández, V Camacho, C de Quintana, O Gallego, J Craven-Bartle, D López, J Molet, B Gómez-Ansón, I Carrió
AIM: To study the usefulness of (18)F-fluorocholine (FCH) in detecting the recurrence of primary brain tumours. MATERIAL AND METHODS: A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumour. The distribution by pathology was: three grade ii astrocytomas, three grade iii astrocytomas, one grade ii oligodendroglioma, three grade iii oligodendrogliomas, one grade iii oligoastrocytoma, four glioblastoma multiform, one gliomatosis cerebri, and five meningiomas...
July 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28156189/feline-glioma-a-retrospective-study-and-review-of-the-literature
#18
Daniel R Rissi, Andrew D Miller
Case series summary This study aimed to evaluate the pathologic and diagnostic features of 13 cases of feline glioma diagnosed at two veterinary diagnostic institutions over 16 years. A retrospective search was conducted using the laboratory information system. Selected cases were reviewed, tumors were classified according to the 2007 World Health Organization Classification of Tumours of the Central Nervous System, and tissue sections were submitted to an immunohistochemistry panel for further characterization...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28126976/-gliomatosis-cerebri-as-a-clinical-entity
#19
Kazuhiko Sugiyama
Gliomatosis cerebri is a rare subtype of glioma involving more than three lobes of the central nervous system. Currently, diagnosis of gliomatosis cerebri can be confirmed pathologically, surgically, or with magnetic resonance imaging that shows high-signal areas expanding to the cerebral hemisphere, brain stem, cerebellum, and spinal cord. Although this disease has great clinical importance, it has recently been removed from the revised WHO classification of Tumors of the Central Nervous System (2016) owing to divergence between its morphological features and molecular profiles...
January 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28074710/canine-spinal-cord-glioma
#20
Daniel R Rissi, Renee Barber, Annabelle Burnum, Andrew D Miller
Spinal cord glioma is uncommonly reported in dogs. We describe the clinicopathologic and diagnostic features of 7 cases of canine spinal cord glioma and briefly review the veterinary literature on this topic. The median age at presentation was 7.2 y. Six females and 1 male were affected and 4 dogs were brachycephalic. The clinical course lasted from 3 d to 12 wk, and clinical signs were progressive and associated with multiple suspected neuroanatomic locations in the spinal cord. Magnetic resonance imaging of 6 cases revealed T2-weighted hyperintense lesions with variable contrast enhancement in the spinal cord...
January 2017: Journal of Veterinary Diagnostic Investigation
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