keyword
MENU ▼
Read by QxMD icon Read
search

Blood patch

keyword
https://www.readbyqxmd.com/read/29779209/gata3-hypermethylation-and-foxp3-hypomethylation-are-associated-with-sustained-protection-and-bystander-effect-following-epicutaneous-immunotherapy-in-peanut-sensitized-mice
#1
Lucie Mondoulet, Vincent Dioszeghy, Florence Busato, Camille Plaquet, Véronique Dhelft, Kevin Bethune, Laurence Leclere, Christian Daviaud, Mélanie Ligouis, Hugh Sampson, Christophe Dupont, Jörg Tost
BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). METHODS: BALB/c mice orally sensitized to peanut proteins (PPE) were treated by EPIT using a PPE-patch or by PPE-OIT...
May 19, 2018: Allergy
https://www.readbyqxmd.com/read/29777885/posttraumatic-cerebrospinal-fluid-leak-associated-with-an-upper-cervical-meningeal-diverticulum
#2
Noriya Enomoto, Hideo Mure, Toshiyuki Okazaki, Mai Azumi, Shinya Okita, Shinji Nagahiro, Yasushi Takagi
Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis is still unclear. Here, we report two cases of SIH as a result of CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who had suffered from orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1/2 level. He underwent epidural blood patch (EBP) therapy, but it was unsuccessful...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29773582/activation-of-large-conductance-calcium-activated-k-channels-by-nitric-oxide-mediates-apelin-induced-relaxation-of-coronary-arteries
#3
Amreen Mughal, Chengwen Sun, Stephen T O'Rourke
Apelin increases coronary blood flow, cardiac contractility and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs are being developed for treating heart failure and related disorders; however, the molecular mechanisms underlying apelin-induced coronary vasodilation are unknown. This study aimed to elucidate the signaling pathways by which apelin causes smooth muscle relaxation in coronary arteries. Receptors for apelin (APJ receptors) were expressed in coronary arteries, as determined by Western blot and PCR analyses...
May 17, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29765818/targeted-epidural-blood-patch-treatment-for-refractory-spontaneous-intracranial-hypotension-in-china
#4
Fei-Fang He, Li Li, Min-Jun Liu, Tai-Di Zhong, Qiao-Wei Zhang, Xiang-Ming Fang
Objective  An epidural blood patch (EBP) is the mainstay of treatment for refractory spontaneous intracranial hypotension (SIH). We evaluated the treatment efficacy of targeted EBP in refractory SIH. Methods  All patients underwent brain magnetic resonance imaging (MRI) with contrast and heavily T2-weighted spine MRI. Whole spine computed tomography (CT) myelography with non-ionic contrast was performed in 46 patients, and whole spine MR myelography with intrathecal gadolinium was performed in 119 patients...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29761781/-post-dural-puncture-headache
#5
Andreas Ravn, Louise Feldborg Lyckhage, Rigmor Jensen
Post-dural puncture headache (PDPH) is a frequent complication to procedures involving dural puncture. The condition is caused by excessive leakage of cerebrospinal fluid through the puncture, and it is most often seen in young women. The risk can be significantly reduced by using smaller, atraumatic needles. PDPH is characterised by a dull headache, which worsens in postural position. Usually, PDPH is a self-limiting condition, which resolves within a week with conservative treatment, but it may become chronic...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29761508/the-microscopic-anatomy-of-the-esophagus-including-the-individual-layers-specialized-tissues-and-unique-components-and-their-responses-to-injury
#6
REVIEW
Xuchen Zhang, Deepa Patil, Robert D Odze, Lei Zhao, Mikhail Lisovsky, Maha Guindi, Robert Riddell, Andrew Bellizzi, Rhonda K Yantiss, Ilke Nalbantoglu, Henry D Appelman
The esophagus, a straight tube that connects the pharynx to the stomach, has the complex architecture common to the rest of the gastrointestinal tract with special differences that relate to its function as a conduit of ingested substances. For instance, it has submucosal glands that are unique and have a specific protective function. It has a squamous lining that exists nowhere else in the gut except the anus and it has a different submucosal nerve plexus when compared to the stomach and intestines. All of the layers of the esophageal wall and the specialized structures including blood and lymphatic vessels and nerves have specific responses to injury...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29761422/computational-pre-surgical-planning-of-arterial-patch-reconstruction-parametric-limits-and-in-vitro-validation
#7
S Samaneh Lashkarinia, Senol Piskin, Tijen A Bozkaya, Ece Salihoglu, Can Yerebakan, Kerem Pekkan
Surgical treatment of congenital heart disease (CHD) involves complex vascular reconstructions utilizing artificial and native surgical materials. A successful surgical reconstruction achieves an optimal hemodynamic profile through the graft in spite of the complex post-operative vessel growth pattern and the altered pressure loading. This paper proposes a new in silico patient-specific pre-surgical planning framework for patch reconstruction and investigates its computational feasibility. The proposed protocol is applied to the patch repair of main pulmonary artery (MPA) stenosis in the Tetralogy of Fallot CHD template...
May 14, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29737302/drug-effect-of-atorvastatin-on-middle-cerebral-atherosclerotic-stenosis-and-high-resolution-nmr-diagnosis
#8
Xingchi Chen, Sainan Wang, Lulu Lin, Yu Li, Hui Zhang
Atherosclerosis (AS) is a chronic inflammatory reaction with the pathological changes in the lipid deposition of arterial intima. The disorder of blood lipid metabolism is the main factor of the occurrence and development of AS, and the inflammatory reaction and autoimmune reaction also run through the development of AS. In this study, we compared the efficacy and safety of atorvastatin, simvastatin, pravastatin and rosuvastatin in the treatment of AS. At the same time, we used high resolution magnetic resonance imaging (MRI) to assess the changes in plaque area in the middle cerebral artery and the patch area before and after drug treatment...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735469/drug-effect-of-atorvastatin-on-middle-cerebral-atherosclerotic-stenosis-and-high-resolution-nmr-diagnosis
#9
Xingchi Chen, Sainan Wang, Lulu Lin, Yu Li, Hui Zhang
Atherosclerosis (AS) is a chronic inflammatory reaction with the pathological changes in the lipid deposition of arterial intima. The disorder of blood lipid metabolism is the main factor of the occurrence and development of AS, and the inflammatory reaction and autoimmune reaction also run through the development of AS. In this study, we compared the efficacy and safety of atorvastatin, simvastatin, pravastatin and rosuvastatin in the treatment of AS. At the same time, we used high resolution magnetic resonance imaging (MRI) to assess the changes in plaque area in the middle cerebral artery and the patch area before and after drug treatment...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29731579/evaluation-of-magnesium-levels-in-blood-and-saliva-of-oral-squamous-cell-carcinoma-and-potentially-malignant-disorders-by-xylidyl-blue-method
#10
Niloufa Z Aziz, K Arathi, B Ganesh Prasad, Dinkar Desai, Sharan J Shetty, Mohammed Shahid
Background: Cancer is Latinized from Greek word 'karkinos' meaning crab, denoting how carcinoma extends its claws like a crab into adjacent tissues. It has been well established by researchers that virtually all oral cancer are preceded by visible clinical changes in the oral mucosa usually in the form of white or red patch (two-step process of cancer development). Mg is an essential mineral that is needed for a broad variety of physiological functions. Imbalances in Mg metabolism are common and are associated with different pathological conditions...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29724819/establishing-the-transient-mass-balance-of-thrombosis-from-tissue-factor-to-thrombin-to-fibrin-under-venous-flow
#11
Shu Zhu, Jason Chen, Scott L Diamond
OBJECTIVE: We investigated the coregulation of thrombin and fibrin as blood flows over a procoagulant surface. APPROACH AND RESULTS: Using microfluidic perfusion of factor XIIa-inhibited human whole blood (200 s- 1 wall shear rate) over a 250-μ long patch of collagen/TF (tissue factor; ≈1 molecule per μm2 ) and immunoassays of the effluent for F1.2 (prothrombin fragment 1.2), TAT (thrombin-antithrombin complex), and D-dimer (post-end point plasmin digest), we sought to establish the transient mass balance for clotting under venous flow...
May 3, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29719651/combined-tenonplasty-and-scleral-graft-for-refractory-pseudomonas-scleritis-following-pterygium-removal-with-mitomycin-c-application
#12
Heidar Siatiri, Nima Mirzaee-Rad, Shruti Aggarwal, Ahmad Kheirkhah
Purpose: To report a surgical approach combining scleral patch graft and tenonplasty for successful management of refractory Pseudomonas scleritis following pterygium removal with mitomycin C application. Case Report: A 75-year-old diabetic woman with a history of prior pterygium excision and mitomycin C application developed infectious necrotizing scleritis caused by Pseudomonas aeruginosa . Owing to progression of scleritis despite medical management, the patient underwent surgery...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29719604/influence-of-aprepitant-and-localization-of-the-patch-on-fentanyl-exposure-in-patients-with-cancer-using-transdermal-fentanyl
#13
Evelien J M Kuip, Wendy H Oldenmenger, Martine F Visser-Thijs, Peter de Bruijn, Esther Oomen-de Hoop, Ron H J Mathijssen, Carin C D Van der Rijt, Stijn W Koolen
Background and Objectives: The cutaneous fentanyl patch is widely used to treat continuous pain in patients with cancer. Its use is hampered by a high inter- and intrapatient pharmacokinetic variability. Factors that influence this pharmacokinetic variability are largely unclear. The aim of these studies was to test if common patient variables, i) the use of the moderate CYP3A4 inhibitor aprepitant and ii) the localization of the fentanyl patch (upper arm versus thorax) influence systemic exposure to fentanyl in patients with cancer using a transdermal fentanyl patch...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29706984/rivastigmine-improves-appetite-by-increasing-the-plasma-acyl-des-acyl-ghrelin-ratio-and-cortisol-in-alzheimer-disease
#14
Yoshiko Furiya, Takami Tomiyama, Tesseki Izumi, Naoki Ohba, Satoshi Ueno
Background: Weight loss accelerates cognitive decline and increases mortality in patients with dementia. While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE inhibitor) to rivastigmine (AChE and butyrylcholinesterase [BuChE] inhibitor) improves appetite. Since BuChE inactivates ghrelin, a potent orexigenic hormone, we speculated that rivastigmine improves appetite by inhibiting BuChE-mediated ghrelin inactivation...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29701398/trauma-an-unusual-cause-of-endocarditis
#15
Ana Braga, Marta Marques, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Infective endocarditis (IE) remains a dangerous condition with considerable associated mortality. Usual risk factors for IE include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of invasive procedures. METHODS: The authors describe the case report of a patient with IE having trauma as an unusual risk factor. RESULTS: A 33-year old male patient was referred to our department due to infective endocarditis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29697782/the-inhibitory-effect-of-bkca-channels-induced-by-autoantibodies-against-angiotensin-ii-type-1-receptor-is-independent-of-at1r
#16
Peng Wang, Suli Zhang, Jie Ren, Li Yan, Lina Bai, Li Wang, Pengli Wang, Jingwei Bian, Xiaochen Yin, Huirong Liu
Autoantibodies against angiotensin II Type 1 receptor (AT1-AA) are routinely detected in the serum of preeclampsia patients, which results in an increase in vascular tone and an elevation in intracellular calcium concentration of rat vascular smooth muscle (VSM). The big conductance calcium-activated potassium channels (BKCa channels) account for the dominant outward currents in VSMCs, contributing to membrane hyperpolarization and vasodilation. In the present study, we investigated the effect of AT1-AA on BKCa channels...
April 25, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29697377/challenges-and-management-of-congenital-abdominal-wall-defects-review
#17
D G Chakhunashvili, N Lomidze, L Karalashvili, L Kikalishvili, K Chakhunashvili, Z Kakabadze
Management of congenital abdominal wall malformations is still a challenge in paediatric surgery due to visceroabdominal disproportion, large defects of abdominal wall and immature abdominal cavity. Most of the patients treated with primary closure need artificial substitutes like patches or biomaterials for non-permanent abdominal wall closure. Patches represent the source of constant infections and complications like separation of prosthesis from fascia. Removal of these patches and ventral hernia repair is essential afterwards...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29695581/celiac-trunk-stenosis-treated-by-resection-and-splenic-patch-reconstruction-a-case-report-and-literature-review
#18
Nicolae Bacalbasa, Irina Balescu, Vladislav Brasoveanu
Celiac trunk stenosis is a relatively common finding; the most common causes of this obstruction are median arcuate ligament syndrome, pancreatitis, local invasion of various malignancies originating from the pancreatic body, atherosclerosis or it can be idiopathic. However, most such cases remain asymptomatic for a long period of time, especially due to the presence of a patent collateral circulation originating from the superior mesenteric artery. In certain cases, the patient might become symptomatic, diffuse post-prandial pain being reported...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29687077/efficacy-and-outcomes-of-intrathecal-analgesia-as-part-of-an-enhanced-recovery-pathway-in-colon-and-rectal-surgical-patients
#19
Amit Merchea, Jenna K Lovely, Adam K Jacob, Dorin T Colibaseanu, Scott R Kelley, Kellie L Mathis, Grant M Spears, Marianne Huebner, David W Larson
Purpose: Multimodal analgesia is an essential component of an enhanced recovery pathway (ERP). An ERP that includes the use of single-injection intrathecal analgesia (IA) has been shown to decrease morbidity and cost and shorten length of stay (LOS). Limited data exist on safety, feasibility, and the optimal IA regimen. Our objective was to characterize the efficacy, safety, and feasibility of IA within an ERP in a cohort of colorectal surgical patients. Methods: We performed a retrospective review of all consecutive patients aged ≥ 18 years who underwent open or minimally invasive colorectal surgery from October 2012 to December 2013...
2018: Surgery Research and Practice
https://www.readbyqxmd.com/read/29686805/efficacy-of-bilateral-greater-occipital-nerve-block-in-postdural-puncture-headache-a-narrative-review
#20
REVIEW
Abhijit S Nair, Praveen Kumar Kodisharapu, Poornachand Anne, Mohammad Salman Saifuddin, Christopher Asiel, Basanth Kumar Rayani
The Epidural blood patch is considered the gold standard for managing postdural puncture headache when supportive measures fail. However, it is a procedure which can lead to another inadvertent dural puncture. Other potential adverse events that could occur during a blood patch are meningitis, neurological deficits, and unconsciousness. The bilateral greater occipital nerve block has been used for treating chronic headaches in patients with PDPH with a single injection. This minimally invasive, simple procedure can be considered for patients early, along with other supportive treatment, and an epidural blood patch can be avoided...
April 2018: Korean Journal of Pain
keyword
keyword
42817
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"