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https://www.readbyqxmd.com/read/28655154/risk-model-for-deaths-and-renal-replacement-therapy-dependence-in-patients-with-acute-kidney-injury-after-cardiac-surgery
#1
Shiren Sun, Feng Ma, Qiaoneng Li, Ming Bai, Yangping Li, Yan Yu, Chen Huang, Hanmin Wang, Xiaoxuan Ning
OBJECTIVES: Acute kidney injury (AKI) is a serious complication after cardiac surgery and is associated with increased in-hospital deaths. Renal replacement therapy (RRT) is becoming a routine strategy for severe AKI. Our goal was to evaluate the risk factors for death and RRT dependence in patients with AKI after cardiac surgery. METHODS: We included 190 eligible adult patients who had AKI following cardiac surgery and who required RRT at our centre from November 2010 to March 2015...
June 23, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28655065/impact-of-acute-intestinal-ischemia-and-reperfusion-injury-on-hemodynamics-and-remote-organs-in-a-rat-model
#2
Meng Wang, Rabea Verhaegh, Konstantinos Tsagakis, Lisa Brencher, Denise Zwanziger, Heinz G Jakob, Herbert de Groot, Daniel-Sebastian Dohle
No abstract text is available yet for this article.
June 27, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28654770/md-2-regulates-lps-induced-nlrp3-inflammasome-activation-and-il-1beta-secretion-by-a-myd88-nf-%C3%AE%C2%BAb-dependent-pathway-in-alveolar-macrophages-cell-line
#3
Man Luo, Lijuan Hu, Dandan Li, Yanying Wang, Yuting He, Lei Zhu, Weiying Ren
Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome aggravates inflammation in LPS-induced ALI. However, there is currently little known about the relationship between MD-2 signaling and the NLRP3 inflammasome. This study showed that NLRP3 expression, IL-1beta (IL-1β) secretion, and pyroptosis were up-regulated after LPS stimulation in the NR8383 AM cell-line...
June 24, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28654550/promoters-and-barriers-to-implementation-of-tracheal-intubation-airway-safety-bundle-a-mixed-method-analysis
#4
Katherine Finn Davis, Natalie Napolitano, Simon Li, Hayley Buffman, Kyle Rehder, Matthew Pinto, Sholeen Nett, J Dean Jarvis, Pradip Kamat, Ronald C Sanders, David A Turner, Janice E Sullivan, Kris Bysani, Anthony Lee, Margaret Parker, Michelle Adu-Darko, John Giuliano, Katherine Biagas, Vinay Nadkarni, Akira Nishisaki
OBJECTIVES: To describe promoters and barriers to implementation of an airway safety quality improvement bundle from the perspective of interdisciplinary frontline clinicians and ICU quality improvement leaders. DESIGN: Mixed methods. SETTING: Thirteen PICUs of the National Emergency Airway Registry for Children network. INTERVENTION: Remote or on-site focus groups with interdisciplinary ICU staff. Two semistructured interviews with ICU quality improvement leaders with quantitative and qualitative data-based feedbacks...
June 24, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28654465/high-velocity-paint-gun-injuries
#5
Wendi E Wohltmann, Joshua A Wisell, Celina M C Lafrades, Daniel M Cramer, Bruce D Ragsdale
Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. More developed lesions (120-192 hours after injury) have prominent histiocytes and fibrosis around necrotic foci, possibly with the pitfall of muscle regenerative giant cells that could be mistaken for sarcoma...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654442/low-intensity-pulsed-ultrasound-therapy-for-a-symptomatic-persistent-olecranon-physis-in-an-adolescent-baseball-pitcher
#6
Kenneth Botwin, Thurston McMillen, Ariel Botwin
A 15-year-old competitive right-handed high school baseball pitcher experienced an acute onset of right elbow pain when throwing. He initially treated it conservatively with rest alone for 3 months, but on return to throwing, he was still experiencing pain. Radiographs revealed that he had a persistent olecranon physis. He proceeded with a trial of low-intensity pulsed ultrasound therapy and attained radiographic evidence of bony union at 7 months postinjury, thus avoiding surgical intervention. He returned to pitching competitively 9 months after injury without elbow pain...
June 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28654378/pet-study-of-sphingosine-1-phosphate-receptor-1-expression-in-response-to-vascular-inflammation-in-a-rat-model-of-carotid-injury
#7
Hui Liu, Hongjun Jin, Xuyi Yue, Junbin Han, Pamela Baum, Dana R Abendschein, Zhude Tu
Sphingosine-1-phosphate receptor (S1PR) activation plays a key role in vascular inflammatory response. Here, we report in vivo validation of [(11)C]TZ3321, a potent S1PR1 radioligand, for imaging vascular inflammation in a rat model of carotid injury. The right common carotid artery of male adult Sprague-Dawley rats was injured by balloon overinflation that denuded the endothelium and distended the vessel wall. Animals received a 60-minute micro-positron emission tomography (micro PET) scan with [(11)C]TZ3321 at 72 hours after injury...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654159/acute-alcohol-exposure-and-risk-of-mortality-of-patients-with-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#8
Qiuping Ding, Zhuo Wang, Meifen Shen, Zhongzhou Su, Liang Shen
After traumatic brain injury (TBI), patients usually live with significant disability and socioeconomic burdens. Acute exposure to alcohol is considered a major risk factor for TBI. Numerous studies have examined whether alcohol exposure is related to the risk of mortality in patients with TBI, yet the results remain inconsistent. We performed a meta-analysis to assess whether acute alcohol exposure affects the mortality rate of TBI patients. We searched PubMed, Embase and the Cochrane Library up to November 2015 for relevant studies...
June 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28654066/a-mouse-model-of-single-and-repetitive-mild-traumatic-brain-injury
#9
Bevan S Main, Stephanie S Sloley, Sonia Villapol, David N Zapple, Mark P Burns
Mild Traumatic Brain Injury (mTBI) can result in the acute loss of brain function, including a period of confusion, a loss of consciousness (LOC), focal neurological deficits and even amnesia. Athletes participating in contact sports are at high risk of exposure to large number of mTBIs. In terms of the level of injury in a sporting athlete, a mTBI is defined as a mild injury that does not cause gross pathological changes, but does cause short-term neurological deficits that are spontaneously resolved. Despite previous attempts to model mTBI in mice and rats, many have reported gross adverse effects including skull fractures, intracerebral bleeding, axonal injury and neuronal cell death...
June 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653963/does-acupressure-hit-the-mark-a-three-arm-randomized-placebo-controlled-trial-of-acupressure-for-pain-and-anxiety-relief-in-athletes-with-acute-musculoskeletal-sports-injuries
#10
Aleksandra K Mącznik, Anthony G Schneiders, Josie Athens, S John Sullivan
OBJECTIVES: Injuries are a common consequence of sports and recreational activity. The optimal management of symptoms is a crucial element of sports injury management. Acupressure has previously been shown to effectively decrease symptoms of musculoskeletal injury, thus may be considered a potentially useful intervention in the management of sport-related injuries. Therefore, this study was conducted to examine the effectiveness of acupressure in decreasing pain and anxiety in acutely injured athletes...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653866/the-role-of-athletic-trainers-in-preventing-and-managing-posttraumatic-osteoarthritis-in-physically-active-populations-a-consensus-statement-of-the-athletic-trainers-osteoarthritis-consortium
#11
Riann M Palmieri-Smith, Kenneth L Cameron, Lindsey J DiStefano, Jeffrey B Driban, Brian Pietrosimone, Abbey C Thomas, Timothy W Tourville, Athletic Trainers' Osteoarthritis Consortium
OBJECTIVE:   To provide athletic trainers with a fundamental understanding of the pathogenesis and risk factors associated with the development of posttraumatic osteoarthritis (PTOA) as well as the best current recommendations for preventing and managing this condition. BACKGROUND:   Posttraumatic osteoarthritis, or osteoarthritis that develops secondary to joint injury, accounts for approximately 5.5 million US cases annually. A young athlete with a joint injury is at high risk for PTOA before the age of 40, which could lead to the patient living more than half of his or her life with a painful and disabling disorder...
June 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28653763/pericentral-hepatocytes-produce-igf-2-to-promote-liver-regeneration-during-special-injuries
#12
Junlai Liu, Xiao Hu, Jie Chen, Xinqi Li, Lu Wang, Binbin Wang, Wenbo Peng, Cuiwei Yang, Zhijie Li, Yan Chen, Yue J Wang, Chuanjiang Li, Xiajun Li, Fang Yan, Yunfang Wang, Changzhen Shang, Xin Wang, Tao Chen, Pengyu Huang
Liver regeneration happens after various types of injuries. Unlike the well-studied liver regeneration caused by partial hepatectomy, there is accumulating evidence suggesting that liver regeneration during other injuries may result from some unknown mechanism. In this study, we found that insulin-like growth factor 2 (IGF-2) was drastically induced following the liver injuries caused by tyrosinemia or long-term treatments of carbon tetrachloride (CCl4 ). However, it was not observed during the early phase of acute liver injuries after partial hepatectomy or single treatment of CCl4 ...
June 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28653674/effects-of-orthotic-therapeutic-electrical-stimulation-in-the-treatment-of-patients-with-paresis-associated-with-acute-cervical-spinal-cord-injury-a-randomized-control-trial
#13
K Iwahashi, T Hayashi, R Watanabe, A Nishimura, T Ueta, T Maeda, K Shiba
STUDY DESIGN: A randomized controlled trial. OBJECTIVES: To determine the effects of orthotic therapeutic electrical stimulation (TES) on the hand in patients with paresis associated with acute cervical spinal cord injury. SETTING: Spinal Injuries Center, Fukuoka, Japan. METHODS: The study included patients treated for spinal cord injuries (Frankel classification, grades B and C) at our institution within 1 week post injury between May 2011 and December 2014...
June 27, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28653327/are-severely-injured-trauma-victims-in-norway-offered-advanced-pre-hospital-care-national-retrospective-observational-cohort
#14
T Wisborg, E N Ellensen, I Svege, T Dehli
BACKGROUND: Studies of severely injured patients suggest that advanced pre-hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the greatest need. Norway has 19 Emergency Helicopters (HEMS) staffed by anaesthesiologists on duty 24/7/365. National regulations describe indications for their use, and the use of the national emergency medical dispatch guideline is recommended. We assessed whether severely injured patients had been treated or transported by advanced resources on a national scale...
June 26, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28653135/closed-loop-mechanical-ventilation-for-lung-injury-a-novel-physiological-feedback-mode-following-the-principles-of-the-open-lung-concept
#15
David Schwaiberger, Philipp A Pickerodt, Anake Pomprapa, Onno Tjarks, Felix Kork, Willehad Boemke, Roland C E Francis, Steffen Leonhardt, Burkhard Lachmann
Adherence to low tidal volume (VT) ventilation and selected positive end-expiratory pressures are low during mechanical ventilation for treatment of the acute respiratory distress syndrome. Using a pig model of severe lung injury, we tested the feasibility and physiological responses to a novel fully closed-loop mechanical ventilation algorithm based on the "open lung" concept. Lung injury was induced by surfactant washout in pigs (n = 8). Animals were ventilated following the principles of the "open lung approach" (OLA) using a fully closed-loop physiological feedback algorithm for mechanical ventilation...
June 26, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28652590/the-incidence-risk-factors-and-outcomes-of-postoperative-acute-kidney-injury-in-neurosurgical-critically-ill-patients
#16
Yujun Deng, Jie Yuan, Ruibin Chi, Heng Ye, Dong Zhou, Sheng Wang, Cong Mai, Zhiqiang Nie, Lin Wang, Yiling Zhai, Lu Gao, Danqing Zhang, Linhui Hu, Yiyu Deng, Chunbo Chen
We investigated the incidence, perioperative risk factors, and outcomes of postoperative acute kidney injury (AKI) in neurosurgical critically ill patients. A prospective multicenter cohort study was conducted, enrolling adult patients who underwent neurosurgical procedure and admitted to the neurosurgical intensive care units (ICU). Postoperative AKI was diagnosed within 7 days after surgery based on the Kidney Disease Improving Global Outcomes criteria. Of 624 enrolled patients, postoperative AKI occurred in 84 patients...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652226/a-hybrid-web-based-and-in-person-self-management-intervention-to-prevent-acute-to-chronic-pain-transition-after-major-lower-extremity-trauma-ipact-e-trauma-protocol-for-a-pilot-single-blind-randomized-controlled-trial
#17
Mélanie Bérubé, Céline Gélinas, Géraldine Martorella, José Côté, Nancy Feeley, George-Yves Laflamme, Dominique Rouleau, Manon Choinière
BACKGROUND: Acute pain frequently transitions to chronic pain after major lower extremity trauma (ET). Several modifiable psychological risk and protective factors have been found to contribute to, or prevent, chronic pain development. Some empirical evidence has shown that interventions, including cognitive and behavioral strategies that promote pain self-management, could prevent chronic pain. However, the efficacy of such interventions has never been demonstrated in ET patients. We have designed a self-management intervention to prevent acute to chronic pain transition after major lower extremity trauma (iPACT-E-Trauma)...
June 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28652182/ulinastatin-attenuates-neuropathic-pain-via-the-atp-p2y2-receptor-pathway-in-rat-models
#18
Ying Shi, Wanxiang Qin, Fachuan Nie, Huizhong Wen, Kaizhi Lu, Jian Cui
Ulinastatin, a serine protease inhibitor, which has anti-inflammatory properties and neuroprotective effects, is used to treat acute inflammatory disorders. Recent evidence indicates that administration of ulinastatin alleviates pain in rat model of neuropathic pain. However, its effect on neuropathic pain and the underlying mechanism requires further study. In this study, we evaluated the role of intrathecal administration of ulinastatin in rats with sciatic nerve ligation and observed the effect of ulinastatin on the ATP/P2Y2 receptor pathway...
June 23, 2017: Gene
https://www.readbyqxmd.com/read/28651950/the-loss-of-kr%C3%A3-ppel-like-factor-15-in-foxd1-stromal-cells-exacerbates-kidney-fibrosis
#19
Xiangchen Gu, Sandeep K Mallipattu, Yiqing Guo, Monica P Revelo, Jesse Pace, Timothy Miller, Xiang Gao, Mukesh K Jain, Agnieszka B Bialkowska, Vincent W Yang, John C He, Changlin Mei
Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to halt its progression. Myofibroblast differentiation and proliferation remain critical to the progression of kidney fibrosis. Although canonical Wnt signaling can trigger the activation of myofibroblasts in the kidney, mediators of Wnt inhibition in the resident progenitor cells are unclear...
June 24, 2017: Kidney International
https://www.readbyqxmd.com/read/28651785/septic-arthritis-following-arthroscopic-reconstruction-of-cruciate-ligaments-of-the-knee-retrospective-case-review
#20
Alejo Erice, M Inmaculada Neira, Sergio Vargas-Prada, Ana Chiaraviglio, Javier Gutiérrez-Guisado, Ricardo Rodríguez de Oya
INTRODUCTION: Rupture of cruciate ligaments of the knee is a common injury that is repaired by arthroscopic reconstruction, which can give rise to septic arthritis. The objective of this article is to describe the clinical and microbiological aspects of this entity. METHODS: Retrospective review of cases of septic arthritis following arthroscopic reconstruction of cruciate ligaments of the knee that occurred at a single institution from 2000-2015. According to time elapsed from surgery, infections were classified as acute (< 14 days), subacute (> 14 days and<30 days), and late (> 30 days)...
June 23, 2017: Enfermedades Infecciosas y Microbiología Clínica
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