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https://www.readbyqxmd.com/read/29150934/the-current-status-and-perspectives-regarding-the-clinical-implication-of-intracellular-calcium-in-breast-cancer
#1
REVIEW
Amir Tajbakhsh, Alireza Pasdar, Mehdi Rezaee, Mostafa Fazeli, Saman Soleimanpour, Seyed Mahdi Hassanian, Zahra FarshchiyanYazdi, Tayebe Younesi Rad, Gordon A Ferns, Amir Avan
Calcium ions (Ca(2+) ) act as second messengers in intracellular signaling. Ca(2+) pumps, channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular Ca(2+) as a key regulator of important cellular processes such as gene expression, proliferation, differentiation, DNA repair, apoptosis, metastasis, and hormone secretion. Intracellular Ca(2+) also influences the functions of several organelles, that include: the endoplasmic reticulum, mitochondria, the Golgi, and cell membrane both in normal and breast cancer cells...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150746/correlation-between-quantitative-pivot-shift-and-generalized-joint-laxity-a-prospective-multicenter-study-of-acl-ruptures
#2
David Sundemo, Anna Blom, Yuichi Hoshino, Ryosuke Kuroda, Nicola Francesco Lopomo, Stefano Zaffagnini, Volker Musahl, James J Irrgang, Jón Karlsson, Kristian Samuelsson
PURPOSE: To investigate whether an increased magnitude of quantitative rotatory knee laxity is associated with a greater level of generalized joint laxity in ACL-injured and contralateral knees. METHODS: A total of 103 patients were enrolled across four international centers to undergo anatomic ACL reconstruction. Rotatory knee laxity was evaluated preoperatively, both in the awake state and under anesthesia, using the standardized pivot shift test. Two devices were used to quantify rotatory knee laxity; an inertial sensor, measuring the joint acceleration, and an image analysis system, measuring the lateral compartment translation of the tibia...
November 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29150669/genome-wide-survey-indicates-diverse-physiological-roles-of-the-turnip-brassica-rapa-var-rapa-calcium-dependent-protein-kinase-genes
#3
Qiuli Wang, Xin Yin, Qian Chen, Nan Xiang, Xudong Sun, Yunqiang Yang, Yongping Yang
Calcium-dependent protein kinases (CDPKs) as crucial sensors of calcium concentration changes play important roles in responding to abiotic and biotic stresses. In this study, 55 BrrCDPK genes, which were phylogenetically clustered into four subfamilies, were identified. Chromosome locations indicated that the CDPK family in turnip expanded by segmental duplication and genome rearrangement. Moreover, gene expression profiles showed that different BrrCDPKs were expressed in specific tissues or stages. Transcript levels of BrrCDPKs indicated that they were involved in abiotic and biotic stresses and that paralogs exhibited functional divergence...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150563/nfat5-regulated-macrophage-polarization-supports-the-proinflammatory-function-of-macrophages-and-t-lymphocytes
#4
Mónica Tellechea, Maria Buxadé, Sonia Tejedor, Jose Aramburu, Cristina López-Rodríguez
Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity involves a precise orchestration of gene expression patterns whose transcriptional regulators have not been fully characterized. We had previously identified the transcription factor NFAT5 as an activator of TLR-induced responses, and in this study we explore its contribution to macrophage functions in different polarization settings...
November 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150090/graph-based-representation-of-behavior-in-detection-and-prediction-of-daily-living-activities
#5
Piotr Augustyniak, Grażyna Ślusarczyk
Various surveillance systems capture signs of human activities of daily living (ADLs) and store multimodal information as time line behavioral records. In this paper, we present a novel approach to the analysis of a behavioral record used in a surveillance system designed for use in elderly smart homes. The description of a subject's activity is first decomposed into elementary poses - easily detectable by dedicated intelligent sensors - and represented by the share coefficients. Then, the activity is represented in the form of an attributed graph, where nodes correspond to elementary poses...
November 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29150069/effect-of-a-mobile-health-sensor-driven-asthma-management-platform-on-asthma-control
#6
Meredith A Barrett, Olivier Humblet, Justine E Marcus, Kelly Henderson, Ted Smith, Nemr Eid, J Wesley Sublett, Andrew Renda, LaQuandra Nesbitt, David Van Sickle, David Stempel, James L Sublett
BACKGROUND: Asthma inflicts a significant health and economic burden in the United States. Self-management approaches to monitoring and treatment can be burdensome for patients. OBJECTIVE: To assess the effect of a digital health management program on asthma outcomes. METHODS: Residents of Louisville, Kentucky, with asthma were enrolled in a single-arm pilot study. Participants received electronic inhaler sensors that tracked the time, frequency, and location of short-acting β-agonist (SABA) use...
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29149722/effects-of-middle-ear-quasi-static-stiffness-on-sound-transmission-quantified-by-a-novel-3-axis-optical-force-sensor
#7
Ivo Dobrev, Jae Hoon Sim, Baktash Aqtashi, Alexander M Huber, Thomas Linder, Christof Röösli
BACKGROUND: Intra-operative quantification of the ossicle mobility could provide valuable feedback for the current status of the patient's conductive hearing. However, current methods for evaluation of middle ear mobility are mostly limited to the surgeon's subjective impression through manual palpation of the ossicles. This study investigates how middle ear transfer function is affected by stapes quasi-static stiffness of the ossicular chain. The stiffness of the middle ear is induced by a) using a novel fiber-optic 3-axis force sensor to quantify the quasi-static stiffness of the middle ear, and b) by artificial reduction of stapes mobility due to drying of the middle ear...
November 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29149687/pyrrolidinyl-pna-polypyrrole-silver-nanofoam-electrode-as-a-novel-label-free-electrochemical-mirna-21-biosensor
#8
Tawatchai Kangkamano, Apon Numnuam, Warakorn Limbut, Proespichaya Kanatharana, Tirayut Vilaivan, Panote Thavarungkul
A label-free electrochemical miRNA biosensor was developed based on a pyrrolidinyl peptide nucleic acid (acpcPNA)/polypyrrole (PPy)/silver nanofoam (AgNF) modified electrode. The AgNF was electrodeposited as redox indicator on a gold electrode, which was then functionalized with an electropolymerized layer of PPy, a conducting polymer, to immobilize the PNA probes. The fabrication process was investigated by electrochemical impedance spectroscopy. The biosensor was used to detect miRNA-21, a biomarker abnormally expressed in most cancers...
November 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29149624/a-pvc-polypyrrole-sensor-designed-for-beef-taste-detection-using-electrochemical-methods-and-sensory-evaluation
#9
Lingtao Zhu, Xiaodan Wang, Yunxiu Han, Yingming Cai, Jiahui Jin, Hongmei Wang, Liping Xu, Ruijia Wu
An electrochemical sensor for detection of beef taste was designed in this study. This sensor was based on the structure of polyvinyl chloride/polypyrrole (PVC/PPy), which was polymerized onto the surface of a platinum (Pt) electrode to form a Pt-PPy-PVC film. Detecting by electrochemical methods, the sensor was well characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The sensor was applied to detect 10 rib-eye beef samples and the accuracy of the new sensor was validated by sensory evaluation and ion sensor detection...
November 4, 2017: Meat Science
https://www.readbyqxmd.com/read/29149604/nrf1-is-an-er-membrane-sensor-that-is-central-to-cholesterol-homeostasis
#10
Scott B Widenmaier, Nicole A Snyder, Truc B Nguyen, Alessandro Arduini, Grace Y Lee, Ana Paula Arruda, Jani Saksi, Alexander Bartelt, Gökhan S Hotamisligil
Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While the mechanisms by which the ER defends against cholesterol insufficiency are well described, it remains unclear how the ER senses and effectively defends against cholesterol excess. Here, we identify the ER-bound transcription factor nuclear factor erythroid 2 related factor-1, Nrf1/Nfe2L1, as a critical mediator of this process. We show that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149558/quantification-of-humic-substances-in-natural-water-using-nitrogen-doped-carbon-dots
#11
Yan-Fang Guan, Bao-Cheng Huang, Chen Qian, Han-Qing Yu
Dissolved organic matter (DOM) is ubiquitous in aqueous environments and plays a significant role in pollutant mitigation, transformation and organic geochemical circulation. DOM is also capable of forming carcinogenic by-products in the disinfection treatment processes of drinking water. Thus, efficient methods for DOM quantification are highly desired. In this work, a novel sensor for rapid and selective detection of humic substances (HS), a key component of DOM, based on fluorescence quenching of nitrogen-doped carbon quantum dots was developed...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149412/the-translationally-controlled-tumor-protein-and-the-cellular-response-to-ionizing-radiation-induced-dna-damage
#12
Jie Zhang, Grace Shim, Sonia M de Toledo, Edouard I Azzam
The absorption of ionizing radiation by living cells can directly disrupt atomic structures, producing chemical and biological changes. It can also act indirectly through radiolysis of water, thereby generating reactive chemical species that may damage nucleic acids, proteins, and lipids. Together, the direct and indirect effects of radiation initiate a series of biochemical and molecular signaling events that may repair the damage or culminate in permanent physiological changes or cell death. In efforts to gain insight into the mechanisms underlying these effects, we observed a prominent upregulation of the Translationally Controlled Tumor Protein (TCTP) in low dose/low dose rate (137)Cs γ-irradiated cells that was associated with adaptive responses that reduced chromosomal damage to a level lower than what occurs spontaneously...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29149088/model-based-heterogeneous-data-fusion-for-reliable-force-estimation-in-dynamic-structures-under-uncertainties
#13
Babak Khodabandeloo, Dyan Melvin, Hongki Jo
Direct measurements of external forces acting on a structure are infeasible in many cases. The Augmented Kalman Filter (AKF) has several attractive features that can be utilized to solve the inverse problem of identifying applied forces, as it requires the dynamic model and the measured responses of structure at only a few locations. But, the AKF intrinsically suffers from numerical instabilities when accelerations, which are the most common response measurements in structural dynamics, are the only measured responses...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149085/the-design-and-characterization-of-a-prototype-wideband-voltage-sensor-based-on-a-resistive-divider
#14
Fernando Garnacho, Abderrahim Khamlichi, Jorge Rovira
The most important advantage of voltage dividers over traditional voltage transformers is that voltage dividers do not have an iron core with non-linear hysteresis characteristics. The voltage dividers have a linear behavior with respect to over-voltages and a flat frequency response larger frequency range. The weak point of a voltage divider is the influence of external high-voltage (HV) and earth parts in its vicinity. Electrical fields arising from high voltages in neighboring phases and from ground conductors and structures are one of their main sources for systematic measurement errors...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149080/novel-tactile-sensor-technology-and-smart-tactile-sensing-systems-a-review
#15
REVIEW
Liang Zou, Chang Ge, Z Jane Wang, Edmond Cretu, Xiaoou Li
During the last decades, smart tactile sensing systems based on different sensing techniques have been developed due to their high potential in industry and biomedical engineering. However, smart tactile sensing technologies and systems are still in their infancy, as many technological and system issues remain unresolved and require strong interdisciplinary efforts to address them. This paper provides an overview of smart tactile sensing systems, with a focus on signal processing technologies used to interpret the measured information from tactile sensors and/or sensors for other sensory modalities...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149075/a-game-theoretic-approach-for-balancing-energy-consumption-in-clustered-wireless-sensor-networks
#16
Liu Yang, Yinzhi Lu, Lian Xiong, Yang Tao, Yuanchang Zhong
Clustering is an effective topology control method in wireless sensor networks (WSNs), since it can enhance the network lifetime and scalability. To prolong the network lifetime in clustered WSNs, an efficient cluster head (CH) optimization policy is essential to distribute the energy among sensor nodes. Recently, game theory has been introduced to model clustering. Each sensor node is considered as a rational and selfish player which will play a clustering game with an equilibrium strategy. Then it decides whether to act as the CH according to this strategy for a tradeoff between providing required services and energy conservation...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149074/central-cns-and-peripheral-gastric-tissue-selective-monitoring-of-somatostatin-srif-with-micro-sensor-and-voltammetry-in-rats-influence-of-growth-factors-gh-egf
#17
Francesco Crespi
Somatostatin (SRIF) is widely distributed throughout the body, and regulates the endocrine system via interactions with various hormones, including the pituitary growth hormone, the thyroid stimulating hormone and the majority of the hormones of the gastrointestinal tract. SRIF is present in the central nervous system (CNS), where it affects rates of neurotransmission, and is also reported to be active in the intestinal tract, with evidence that stressed rats present a significant decrease in antral somatostatin-like immunoreactivity (SLI)...
November 17, 2017: Biosensors
https://www.readbyqxmd.com/read/29149063/estimating-stair-running-performance-using-inertial-sensors
#18
Lauro V Ojeda, Antonia M Zaferiou, Stephen M Cain, Rachel V Vitali, Steven P Davidson, Leia A Stirling, Noel C Perkins
Stair running, both ascending and descending, is a challenging aerobic exercise that many athletes, recreational runners, and soldiers perform during training. Studying biomechanics of stair running over multiple steps has been limited by the practical challenges presented while using optical-based motion tracking systems. We propose using foot-mounted inertial measurement units (IMUs) as a solution as they enable unrestricted motion capture in any environment and without need for external references. In particular, this paper presents methods for estimating foot velocity and trajectory during stair running using foot-mounted IMUs...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149061/mechanical-corrosion-and-biological-properties-of-room-temperature-sputtered-aluminum-nitride-films-with-dissimilar-nanostructure
#19
Cristina Besleaga, Viorel Dumitru, Liliana Marinela Trinca, Adrian-Claudiu Popa, Constantin-Catalin Negrila, Łukasz Kołodziejczyk, Catalin-Romeo Luculescu, Gabriela-Cristina Ionescu, Razvan-George Ripeanu, Alina Vladescu, George E Stan
Aluminum Nitride (AlN) has been long time being regarded as highly interesting material for developing sensing applications (including biosensors and implantable sensors). AlN, due to its appealing electronic properties, is envisaged lately to serve as a multi-functional biosensing platform. Although generally exploited for its intrinsic piezoelectricity, its surface morphology and mechanical performance (elastic modulus, hardness, wear, scratch and tensile resistance to delamination, adherence to the substrate), corrosion resistance and cytocompatibility are also essential features for high performance sustainable biosensor devices...
November 17, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29149059/a-high-performance-portable-transient-electro-magnetic-sensor-for-unexploded-ordnance-detection
#20
Haofeng Wang, Shudong Chen, Shuang Zhang, Zhiwen Yuan, Haiyang Zhang, Dong Fang, Jun Zhu
Portable transient electromagnetic (TEM) systems can be well adapted to various terrains, including mountainous, woodland, and other complex terrains. They are widely used for the detection of unexploded ordnance (UXO). As the core component of the portable TEM system, the sensor is constructed with a transmitting coil and a receiving coil. Based on the primary field of the transmitting coil and internal noise of the receiving coil, the design and testing of such a sensor is described in detail. Results indicate that the primary field of the transmitting coil depends on the diameter, mass, and power of the coil...
November 17, 2017: Sensors
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