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S Benacchio, O Doutres, A Le Troter, A Varoquaux, E Wagnac, V Callot, F Sgard
Passive and active in-ear devices (IED) occluding the ear canal are commonly used to (i) protect people from high noise levels (earplugs), (ii) assist people suffering from hearing impairment (hearing aids) or (iii) help people in listening from their sound systems (earbuds). However, the usability and/or efficiency of IEDs can be greatly affected by several discomfort components (physical, acoustical and functional). The mechanical pressure exerted by the IED onto the ear canal walls is greatly suspected to affect the aforementioned comfort components...
June 2, 2018: Hearing Research
J M Gonzalez, D Lorenzo, T Guilbaud, T Bège, M Barthet
Background and study aims : Management of post-sleeve gastrectomy fistulas (PSGF) recently has evolved, resulting in prioritization of internal endoscopic drainage (IED). We report our experience with the technique in a tertiary center. Patients and methods:  This was a single-center, retrospective study of 44 patients whose PSGF was managed with IED, comparing two periods: after 2013 (Group 1; n = 22) when IED was used in first line and before 2013 (Group 2; n = 22) when IED was applied in second line...
June 2018: Endoscopy International Open
Vimal Doshi Veerappan, B Sweetha, H R Kavitha, B Sivalingam, Shanthi Nambi, Leema Pauline
Context: A significant subset of autistic children exhibit abnormal isolated epileptiform discharges (IEDs) in the absence of clinical epilepsy. The etiological significance of such IEDs is under much debate. Aims: The aim is to study the relationship between IEDs with risk factors, clinical severity, behavioral problems, and social-quotient and follow-up for the occurrence of new seizures. Settings and Design: This study was a prospective double-blind comparative study of autistic children with and without IEDs...
May 2018: Indian Journal of Psychological Medicine
Abhay Deshmukh, Jared Leichner, Jihye Bae, Yinchen Song, Pedro A Valdés-Hernández, Wei-Chiang Lin, Jorge J Riera
Current clinical practice in focal epilepsy involves brain source imaging (BSI) to localize brain areas where from interictal epileptiform discharges (IEDs) emerge. These areas, named irritative zones , have been useful to define candidate seizures-onset zones during pre-surgical workup. Since human histological data are mostly available from final resected zones, systematic studies characterizing pathophysiological mechanisms and abnormal molecular/cellular substrates in irritative zones-independent of them being epileptogenic-are challenging...
2018: Frontiers in Cellular Neuroscience
Mehmet Alp Dirik, Burcin Sanlidag
INTRODUCTION: Epilepsy is one of the most frequently diagnosed chronic neurological disorders in children. Diagnosis is often based on seizure history and electroencephalography (EEG) assessment. Magnetic resonance imaging (MRI) is recommended for etiologic workup and intervention requirements. We aimed to detect by MRI if focal structural abnormalities are present in the brain in relation to interictal epileptiform discharges (IED). MATERIAL AND METHODS: The study was designed retrospectively...
June 1, 2018: Journal of Clinical Medicine
Montaha Al-Iede, Radhagini Kumaran, Karen Waters
OBJECTIVES: A number of reports exist regarding the use of continuous positive airway pressure (CPAP) to manage obstructive sleep apnoea (OSA) in children, which we term 'conventional CPAP'. In contrast, there are few reports of home CPAP use for other indications, which we have grouped under the term 'cardiopulmonary'. The aims of this study were to (1) document cardiopulmonary indications for CPAP use in a cohort of infants and children, and (2) evaluate its effectiveness in this group...
April 30, 2018: Sleep Medicine
David Koziel, Uwe Michaelis, Tobias Kruse
Endotoxins contaminate proteins that are produced in E. coli. High levels of endotoxins can influence cellular assays and cause severe adverse effects when administered to humans. Thus, endotoxin removal is important in protein purification for academic research and in GMP manufacturing of biopharmaceuticals. Several methods exist to remove endotoxin, but often require additional downstream-processing steps, decrease protein yield and are costly. These disadvantages can be avoided by using an integrated endotoxin depletion (iED) wash-step that utilizes Triton X-114 (TX114)...
May 21, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Emil F Coccaro
OBJECTIVE: This study was designed to estimate how many adults with DSM-5 Intermittent Explosive Disorder (IED) would also meet diagnostic criteria for Disruptive Mood Dysregulation Disorder (DMDD). This was done by examining how many individuals with IED would meet the DMDD criterion of being persistently angry in between impulsive aggressive outbursts. METHODS: The first one-hundred study participants diagnosed with DSM-5 IED in our clinical research program were included in this study...
April 30, 2018: Comprehensive Psychiatry
Kiyotsugu Iede, Akimasa Nakao, Kenji Oshima, Ryota Suzuki, Hironori Yamada, Yukiko Oshima, Hironobu Kobayashi, Yasunori Kimura
PURPOSE: Early ligation of the inferior pancreatoduodenal artery has been advocated to reduce blood loss during pancreatoduodenectomy. However, the impact of early ligation of the dorsal pancreatic artery (DPA) remains unclear. This study was performed to investigate the clinical implications of early ligation of the DPA. METHODS: From October 2014 to April 2017, 34 consecutive patients underwent pancreatoduodenectomy using a mesenteric approach. The patients were divided into the early DPA ligation group (n = 15) and late DPA ligation group (n = 19)...
May 10, 2018: Journal of Hepato-biliary-pancreatic Sciences
Susana Castaninha, Joao Carlos Lopes, Ana Isabel Lopes
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease, with a rising incidence in childhood. The diagnosis is confirmed by esophageal mucosa eosinophil-predominant inflammation. Rare complications, such as intramural esophageal dissection (IED) due to progressive transmural inflammatory and fibrotic process, may occur in young adults. While severe cases can require immediate surgical intervention, conservative management may be also effective, as recently reported by Ibáñez-Sanz et al...
May 3, 2018: Revista Española de Enfermedades Digestivas
L J Van Dijk, M A Lie, E R Van den Heuvel, G A Van der Weijden
OBJECTIVES: To evaluate in patients with untreated adult periodontitis, the effect of treatment with a novel pocket irrigator/evacuator device (IED) compared to conventional subgingival debridement (CPT), both provided during the initial phase of active periodontal therapy. METHODS: This study was an examiner-blind, randomized controlled clinical trial using a split-mouth design. Systemically healthy patients with adult periodontitis were selected. Full-mouth probing pocket depth (PPD), gingival bleeding on pocket probing scores (BOPP), gingival recession (REC) and dental plaque (PI) were assessed at baseline...
April 30, 2018: International Journal of Dental Hygiene
Vinícius Esteves Salgado, Guilherme Ferreira Rego, Luis Felipe Schneider, Rafael Ratto de Moraes, Larissa Maria Cavalcante
OBJECTIVE: To determine if material's translucency influences the cure efficiency and color stability of resin-based composites (RBCs). METHODS: Four commercially-available RBCs indicated for aesthetic restorations were selected in different translucent/opaque shades: IPS Empress Direct (IED) A3 Dentin, A3 Enamel, Trans 20, and Trans 30; Filtek Z350 XT (FZX) A3D, A3B, A3E, and CT; Estelite ∑ Quick (EQ) OA3, A3, and CE; and Opallis (OP) DA3, EA3, and T-Neutral...
April 25, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Yang Wang, Qi Liu, Qin Zhang, Bosi Peng, Hexiang Deng
We report a new approach to create metal-binding site in a series of metal-organic frameworks (MOFs), where tetratopic carboxylate linker, 4',4'',4''',4''''-methanetetrayltetrabiphenyl-4-carboxylic acid, is partially replaced by a tritopic carboxylate linker, tris(4-carboxybiphenyl)amine, in combination with monotopic linkers, formic acid, trifluoroacetic acid, benzoic acid, isonicotinic acid, 4-chlorobenzoic acid, and 4-nitrobenzoic acid, respectively. The distance between these paired-up linkers can be precisely controlled, ranging from 5...
June 11, 2018: Angewandte Chemie
Humberto Nicolini, Rafael Salin-Pascual, Brenda Cabrera, Nuria Lanzagorta
Background: The aspects of cultural identity and its impact on obsessive-compulsive disorder (OCD) have been un-derstudied. There are different opinions, ranging from the idea that culture does not affect the symptoms of this condition to the idea that cultures with high religiosity may have more severity of OCD. Also, the concept of OCD has considerably var-ied across history and cultures, from being considered an issue related to lack of control of blasphemous ideas, and a part of anxious issues, to the description of complex neurobiological systems in its causation...
December 2017: Current Psychiatry Reviews
Radek Janca, Pavel Krsek, Petr Jezdik, Roman Cmejla, Martin Tomasek, Vladimir Komarek, Petr Marusic, Premysl Jiruska
Between seizures, irritative network generates frequent brief synchronous activity, which manifests on the EEG as interictal epileptiform discharges (IEDs). Recent insights into the mechanism of IEDs at the microscopic level have demonstrated a high variance in the recruitment of neuronal populations generating IEDs and a high variability in the trajectories through which IEDs propagate across the brain. These phenomena represent one of the major constraints for precise characterization of network organization and for the utilization of IEDs during presurgical evaluations...
2018: Frontiers in Neurology
Lauren Rynar, Emil F Coccaro
The purpose of this study was to document the functional severity of DSM-5 IED in a clinical research sample. IED and control groups were compared on psychosocial functioning, life satisfaction, and on a variety of cognitive and behavioral issues. IED study participants reported significantly worse psychosocial function, quality of life, and higher job dysfunction than both psychiatric and healthy control study participants. The presence of DSM-5 IED is associated with significant psychosocial and functional impairment...
June 2018: Psychiatry Research
Volkan Gelegen, Lut Tamam
OBJECTIVE: Intermittent explosive disorder (IED) is defined as the failure to resist aggressive impulses resulting in repeated acts of verbal and/or physical aggression. Although it is frequently encountered in clinical psychiatric practice, there is a paucity of data concerning IED in the scientific literature both internationally and in Turkey. The aim of this study was to evaluate the prevalence of IED and associated sociodemographic and clinical features in a clinical setting. METHODS: A total of 406 patients who were referred to our psychiatry outpatient clinic for the first time in a six-month period were included in the study...
May 2018: Comprehensive Psychiatry
Vilas Saldanha, Nathan Tiedeken, Brandon Godfrey, Nichole Ingalls
Background: Since the start of the conflict in the Middle East in 2001, military orthopedic surgeons have faced complex orthopedic injuries including high-energy soft tissue wounds, traumatic amputations, and open fractures. Although orthopedic surgeons are well trained in the management of osseous injuries, the treatment of soft tissue injuries can be technically challenging and unfamiliar. Early washout, debridement of devitalized tissue, external fixation of bony injuries, and antibiotic therapy remain the foundation of early wound management...
March 26, 2018: Military Medicine
Ana M Costa, Gustavo C Medeiros, Sarah Redden, Jon E Grant, Hermano Tavares, Liliana Seger
OBJECTIVES: To evaluate the efficacy of a group therapy based on cognitive-behavioral techniques customized for intermittent explosive disorder (IED). The current report presents the preliminary results of a clinical trial comparing pre- and post-intervention scores in different anger dimensions. METHODS: The studied sample consisted of 84 treatment-seeking subjects. The mean (standard deviation) age was 43.0 (11.9) years, and 78% were male. The therapeutic group program consisted of 15 weekly sessions plus three maintenance sessions...
March 26, 2018: Revista Brasileira de Psiquiatria
Christopher M Daniels, Gabriel J Pavey, Jacob Arthur, Michael Noller, Jonathan A Forsberg, Benjamin K Potter
OBJECTIVES: To determine what proportion of residual limbs formed heterotopic ossification (HO) in amputations sustained by US service members, the injury profile of these amputations, and what effect the number of limb amputations sustained has on resource utilization. DESIGN: Retrospective review. SETTING: A tertiary military medical center. PATIENTS: Four-hundred seventy-one consecutive patients with 714 combat-related amputations were treated at our institution between September 2009 and August 2014...
June 2018: Journal of Orthopaedic Trauma
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