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https://www.readbyqxmd.com/read/29667286/molecular-vise-approach-to-create-metal-binding-sites-in-mofs-and-detection-of-biomarker
#1
Yang Wang, Qi Liu, Qin Zhang, Bosi Peng, Hexiang Deng
We report a new approach to create metal-binding site in a series of metal-organic frameworks (MOFs), where tetra-topic carboxylate linker, 4',4'',4''',4''''-methanetetrayltetrabiphenyl-4-carboxylic acid, is partially replaced by a tri-topic carbox-ylate linker, tris(4-carboxybiphenyl)amine, in combination with mono-topic linkers, formic acid, trifluoroacetic acid, ben-zoic acid, isonicotinic acid, 4-chlorobenzoic acid, and 4-nitrobenzoic acid, respectively. The distance between these paired-up linkers can be precisely controlled, ranging from 5...
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29657563/influence-of-culture-in-obsessive-compulsive-disorder-and-its-treatment
#2
REVIEW
Humberto Nicolini, Rafael Salin-Pascual, Brenda Cabrera, Nuria Lanzagorta
Background: The aspects of cultural identity and its impact on obsessive-compulsive disorder (OCD) have been un-derstudied. There are different opinions, ranging from the idea that culture does not affect the symptoms of this condition to the idea that cultures with high religiosity may have more severity of OCD. Also, the concept of OCD has considerably var-ied across history and cultures, from being considered an issue related to lack of control of blasphemous ideas, and a part of anxious issues, to the description of complex neurobiological systems in its causation...
December 2017: Current Psychiatry Reviews
https://www.readbyqxmd.com/read/29628910/the-sub-regional-functional-organization-of-neocortical-irritative-epileptic-networks-in-pediatric-epilepsy
#3
Radek Janca, Pavel Krsek, Petr Jezdik, Roman Cmejla, Martin Tomasek, Vladimir Komarek, Petr Marusic, Premysl Jiruska
Between seizures, irritative network generates frequent brief synchronous activity, which manifests on the EEG as interictal epileptiform discharges (IEDs). Recent insights into the mechanism of IEDs at the microscopic level have demonstrated a high variance in the recruitment of neuronal populations generating IEDs and a high variability in the trajectories through which IEDs propagate across the brain. These phenomena represent one of the major constraints for precise characterization of network organization and for the utilization of IEDs during presurgical evaluations...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29627702/psychosocial-impairment-in-dsm-5-intermittent-explosive-disorder
#4
Lauren Rynar, Emil F Coccaro
The purpose of this study was to document the functional severity of DSM-5 IED in a clinical research sample. IED and control groups were compared on psychosocial functioning, life satisfaction, and on a variety of cognitive and behavioral issues. IED study participants reported significantly worse psychosocial function, quality of life, and higher job dysfunction than both psychiatric and healthy control study participants. The presence of DSM-5 IED is associated with significant psychosocial and functional impairment...
March 30, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29604524/prevalence-and-clinical-correlates-of-intermittent-explosive-disorder-in-turkish-psychiatric-outpatients
#5
Volkan Gelegen, Lut Tamam
OBJECTIVE: Intermittent explosive disorder (IED) is defined as the failure to resist aggressive impulses resulting in repeated acts of verbal and/or physical aggression. Although it is frequently encountered in clinical psychiatric practice, there is a paucity of data concerning IED in the scientific literature both internationally and in Turkey. The aim of this study was to evaluate the prevalence of IED and associated sociodemographic and clinical features in a clinical setting. METHODS: A total of 406 patients who were referred to our psychiatry outpatient clinic for the first time in a six-month period were included in the study...
March 18, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29590411/wartime-soft-tissue-coverage-techniques-for-the-deployed-surgeon
#6
Vilas Saldanha, Nathan Tiedeken, Brandon Godfrey, Nichole Ingalls
Background: Since the start of the conflict in the Middle East in 2001, military orthopedic surgeons have faced complex orthopedic injuries including high-energy soft tissue wounds, traumatic amputations, and open fractures. Although orthopedic surgeons are well trained in the management of osseous injuries, the treatment of soft tissue injuries can be technically challenging and unfamiliar. Early washout, debridement of devitalized tissue, external fixation of bony injuries, and antibiotic therapy remain the foundation of early wound management...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29590263/cognitive-behavioral-group-therapy-for-intermittent-explosive-disorder-description-and-preliminary-analysis
#7
Ana M Costa, Gustavo C Medeiros, Sarah Redden, Jon E Grant, Hermano Tavares, Liliana Seger
OBJECTIVES: To evaluate the efficacy of a group therapy based on cognitive-behavioral techniques customized for intermittent explosive disorder (IED). The current report presents the preliminary results of a clinical trial comparing pre- and post-intervention scores in different anger dimensions. METHODS: The studied sample consisted of 84 treatment-seeking subjects. The mean (standard deviation) age was 43.0 (11.9) years, and 78% were male. The therapeutic group program consisted of 15 weekly sessions plus three maintenance sessions...
March 26, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29533305/has-the-proportion-of-combat-related-amputations-that-develop-heterotopic-ossification-increased
#8
Christopher M Daniels, Gabriel J Pavey, Jacob Arthur, Michael Noller, Jonathan A Forsberg, Benjamin K Potter
OBJECTIVES: We sought to determine what proportion of residual limbs formed heterotopic ossification (HO) in amputations sustained by US service members, the injury profile of these amputations, and what effect the number of limb amputations sustained has on resource utilization. DESIGN: Retrospective review. SETTING: A tertiary military medical center. PATIENTS: Four-hundred seventy-one consecutive patients with 714 combat-related amputations were treated at our institution between September 2009 and August 2014...
March 5, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29505319/mild-traumatic-brain-injury-and-aggression-impulsivity-and-history-of-other-and-self-directed-aggression
#9
Caterina Mosti, Emil F Coccaro
Mild traumatic brain injury (mTBI) is highly prevalent, with an estimated occurrence in the United States of more than 1.3 million per year. While one consequence of mTBI is impulsive aggressive behavior, very few studies have examined the relationship between history of mTBI and aggressive behavior in impulsively aggressive individuals. The authors examined the relationship between history of mTBI in a healthy control group (HC; N=453), a control group with psychiatric disorders (PC; N=486), and individuals with intermittent explosive disorder (IED; N=695), a disorder of primary impulsive aggression...
March 5, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29500817/effect-of-noise-on-mtf-calculations-using-different-phantoms
#10
Antonio González-López
PURPOSE: In this work, the effect of noise on the precision in the modulation transfer function (MTF) calculation using different phantoms is investigated. Three different techniques are stud-ied, based on three different phantoms: edge, bar and star bar. For each technique, theoretical expressions for the standard deviation and the signal to noise ratio (SNR) of the MTF are derived. In addition, Monte Carlo simulations are carried out to study the accuracy and precision of all the three techniques...
March 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29455060/major-depressive-disorder-and-depressive-symptoms-in-intermittent-explosive-disorder
#11
Gustavo C Medeiros, Liliana Seger, Jon E Grant, Hermano Tavares
It is estimated that between 1.7 and 2.6 million people have had intermittent explosive disorder (IED) during their life in the United States alone. Co-occurring psychiatric disorders are very common in IED, being major depressive disorder arguably the most common. The objective of this study was to examine the clinical correlates of IED and depressive manifestations in 74 treatment-seeking subjects. After controlling for confounders, there were associations between major depressive disorder and severity of depressive symptoms, and (a) higher assault scores, (b) more severe hostile behavior and (c) worse social adjustment...
February 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29414405/eeg-synchronization-measures-predict-epilepsy-related-bold-fmri-fluctuations-better-than-commonly-used-univariate-metrics
#12
Rodolfo Abreu, Alberto Leal, Fernando Lopes da Silva, Patrícia Figueiredo
OBJECTIVE: We hypothesize that the hypersynchronization associated with epileptic activity is best described by EEG synchronization measures, and propose to use these as predictors of epilepsy-related BOLD fluctuations. METHODS: We computed the phase synchronization index (PSI) and global field synchronization (GFS), within two frequency bands, a broadband (1-45 Hz) and a narrower band focused on the presence of epileptic activity (3-10 Hz). The associated epileptic networks were compared with those obtained using conventional unitary regressors and two power-weighted metrics (total power and root mean square frequency), on nine simultaneous EEG-fMRI datasets from four epilepsy patients, exhibiting inter-ictal epileptiform discharges (IEDs)...
January 11, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29412775/opposing-effects-of-2-deoxy-d-glucose-on-interictal-and-ictal-like-activity-when-k-currents-and-gaba-a-receptors-are-blocked-in-rat-hippocampus-in-vitro
#13
Steen Nedergaard, Mogens Andreasen
The ketogenic diet (KD), a high-fat, carbohydrate-restricted diet, is used as an alternative treatment for drug-resistant epileptic patients. Evidence suggests that compromised glucose metabolism has a significant role in the anticonvulsant action of the KD, however, it is unclear what part of the glucose metabolism that is important. The present study investigates how selective alterations in glycolysis and oxidative phosphorylation influence epileptiform activity induced by blocking K+ currents, GABAA and NMDA receptors in the hippocampal slice preparation...
February 7, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29412066/alkalinity-and-external-carbon-requirements-for-denitrification-nitrification-of-coke-wastewater
#14
Eleanor Raper, Raymond Fisher, David R Anderson, Tom Stephenson, Ana Soares
The Industrial Emissions Directive (IED) requires that coke wastewater is treated to reach an effluent with <50 mg/L total nitrogen (TN). A shortage of alkalinity (3.6 mg as CaCO3/mg NH4+-N) in the wastewater limited nitrification to 45%. Various compounds were tested as a source of additional alkalinity, with optimal results being found for sodium carbonate, which enabled 95% nitrification at 300 mg/L (as CaCO3). Sodium bicarbonate led to incomplete ammonia oxidation (76%) whilst soda ash prevented nitrite oxidation...
February 7, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29394439/development-of-the-caveman-human-body-model-validation-of-lower-extremity-sub-injurious-response-to-vertical-accelerative-loading
#15
Kent Butz, Chad Spurlock, Rajarshi Roy, Cameron Bell, Paul Barrett, Aaron Ward, Xudong Xiao, Allen Shirley, Colin Welch, Kevin Lister
Improving injury prediction accuracy and fidelity for mounted Warfighters has become an area of focus for the U.S. military in response to improvised explosive device (IED) use in both Iraq and Afghanistan. Although the Hybrid III anthropomorphic test device (ATD) has historically been used for crew injury analysis, it is only capable of predicting a few select skeletal injuries. The Computational Anthropomorphic Virtual Experiment Man (CAVEMAN) human body model is being developed to expand the injury analysis capability to both skeletal and soft tissues...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29390508/analysis-of-early-death-in-newly-diagnosed-acute-promyelocytic-leukemia-patients
#16
Fang Xu, Chunli Wang, Changxin Yin, Xuejie Jiang, Ling Jiang, Zhixiang Wang, Fanyi Meng
The aim of this study was to identify risk factors for early death (ED) in acute promyelocitic leukemia (APL) patients.Clinical records of 49 APL patients who suffered ED were divided into 4 groups: death before treatment or within the first 3 days (immediate death; iED group), death during treatment at least 3 days after commencement (ED after treatment), low/intermediate risk, and high-risk groups.White blood cell (WBC) count, high-risk cases, prothrombin time (PT) prolongation, international society on thrombosis and hemostasis (ISTH) scores (P < ...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382740/a-plastidial-pantoate-transporter-with-a-potential-role-in-pantothenate-synthesis
#17
Lili Huang, Michal Pyc, Saleh Alseekh, Donald R McCarty, Valérie de Crécy-Lagard, Jesse F Gregory, Christopher S Henry, Alisdair R Fernie, Robert T Mullen, Andrew D Hanson
The pantothenate (vitamin B5 ) synthesis pathway in plants is not fully defined because the subcellular site of its ketopantoate → pantoate reduction step is unclear. However, the pathway is known to be split between cytosol, mitochondria, and potentially plastids, and inferred to involve mitochondrial or plastidial transport of ketopantoate or pantoate. No proteins that mediate these transport steps have been identified. Comparative genomic and transcriptomic analyses identified Arabidopsis thaliana BASS1 (At1g78560) and its maize ( Zea mays ) ortholog as candidates for such a transport role...
February 28, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29377984/longer-inter-lead-electrical-delay-is-associated-with-response-to-cardiac-resynchronization-therapy-in-patients-with-presumed-optimal-left-ventricular-lead-position
#18
Anders Sommer, Mads Brix Kronborg, Bjarne Linde Nørgaard, Charlotte Stephansen, Steen Hvitfeldt Poulsen, Jens Kristensen, Christian Gerdes, Jens Cosedis Nielsen
Aims: In a randomized trial of cardiac resynchronization therapy (CRT), a presumed optimal left ventricular (LV) lead position close to the latest mechanically activated non-scarred myocardium was achieved in 98% of patients by standard implantation. We evaluated whether inter-lead electrical delay (IED) was associated with response to CRT in these patients. Methods and results: We prospectively included 160 consecutive patients undergoing CRT. Pre-implant speckle-tracking echocardiography radial strain and 99mTc myocardial perfusion imaging determined the latest mechanically activated non-scarred myocardial segment...
January 25, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29370057/analysis-of-isolated-transverse-process-fractures-sustained-during-blast-related-events
#19
Nicolas Newell, A Phillip Pearce, Edward Spurrier, Iain Gibb, Claire E Webster, Spyros D Masouros, Jonathan C Clasper
BACKGROUND: A range of devastating blast injuries have been sustained by personnel during recent conflicts. Previous studies have focused on severe injuries, including to the spine, however, no study has specifically focused on the most common spinal injury; transverse process (TP) fractures. Although their treatment usually requires limited intervention, analysis of TP fractures may help determine injury mechanisms. METHODS: Data was collected from victims with spinal fractures injured in Improvised Explosive Device (IED) attacks, from the UK's Joint Theatre Trauma Registry...
January 24, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29353562/impaired-cognitive-plasticity-and-goal-directed-control-in-adolescent-obsessive-compulsive-disorder
#20
Julia Gottwald, Sanne de Wit, Annemieke M Apergis-Schoute, Sharon Morein-Zamir, Muzaffer Kaser, Francesca Cormack, Akeem Sule, Winifred Limmer, Anna Conway Morris, Trevor W Robbins, Barbara J Sahakian
BACKGROUND: Youths with obsessive-compulsive disorder (OCD) experience severe distress and impaired functioning at school and at home. Critical cognitive domains for daily functioning and academic success are learning, memory, cognitive flexibility and goal-directed behavioural control. Performance in these important domains among teenagers with OCD was therefore investigated in this study. METHODS: A total of 36 youths with OCD and 36 healthy comparison subjects completed two memory tasks: Pattern Recognition Memory (PRM) and Paired Associates Learning (PAL); as well as the Intra-Extra Dimensional Set Shift (IED) task to quantitatively gauge learning as well as cognitive flexibility...
January 22, 2018: Psychological Medicine
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