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craniocerebral trauma

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https://www.readbyqxmd.com/read/29393419/hmgb1-mediates-microglia-activation-via-the-tlr4-nf-%C3%AE%C2%BAb-pathway-in-coriaria-lactone-induced-epilepsy
#1
Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Miao
Epilepsy is a chronic and recurrent disease of the central nervous system, with a complex pathology. Recent studies have demonstrated that the activation of glial cells serve an important role in the development of epilepsy. The objective of the present study was to investigate the role of high‑mobility group box‑1 (HMGB1) in mediating the activation of glial cells through the toll‑like receptor 4 (TLR4)/nuclear factor (NF)‑κB signaling pathway in seizure, and the underlying mechanism. The brain tissue of post‑surgery patients with intractable epilepsy after resection and the normal control brain tissue of patients with craniocerebral trauma induced intracranial hypertension were collected...
January 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29305023/early-vs-late-fracture-fixation-in-severe-head-and-orthopedic-injuries
#2
Yuan Zhang, Kai Sun, Yuling Wang, Yafei Qin, Hui Li
BACKGROUND: Patients suffered from craniocerebral trauma with extermities fracture is one of the most common multiple injuries.Actually there is no comparative study demonstrating advantages of early or delayed treatment of skeletal injuries. PURPOSES: To conduct a meta-analysis with studies published in full text to demonstrate database to show the associations of perioperative, postoperative outcomes of early fracture fixation(EFF) and late fracture fixation(LFF) for patients with severe head and orthopedic injuries to provide the predictive diagnosis for clinic...
December 29, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29284906/may-heading-in-soccer-result-in-traumatic-brain-injury-a-review-of-literature
#3
REVIEW
Gorazd Bunc, Janez Ravnik, Tomaz Velnar
Background: Globally, soccer is the most popular team sport, unifying many fans all around the world. The epidemiological studies so far have confirmed that head playing and hitting the ball with head may cause minor head injuries, which exert their effects in a cumulative way. Methods: Literature search for this review was conducted and data about traumatic brain injury collected from various sources. Results: The consequences of head injury are evident as chronic changes in cognition, including disturbances in concentration and slowing of mental and physical agility...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29231022/-forensic-psychiatric-assessment-for-organic-personality-disorders-after-craniocerebral-trauma
#4
C H Li, L N Huang, M C Zhang, M He
OBJECTIVES: To explore the occurrence and the differences of clinical manifestations of organic personality disorder with varying degrees of craniocerebral trauma. METHODS: According to the International Classification of Diseases-10, 396 subjects with craniocerebral trauma caused by traffic accidents were diagnosed, and the degrees of craniocerebral trauma were graded. The personality characteristics of all patients were evaluated using the simplified Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI)...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/28962188/dynamic-changes-of-%C3%AE-melanocyte-stimulating-hormone-levels-in-the-serum-of-patients-with-craniocerebral-trauma
#5
Xiaoguang Du, Baozhong Dong, Chen Li, Faxue Zhang, Yanwei Ji, Jianbin Zhang, Changjiang Yin
The aim of the study was to investigate dynamic changes in α-melanocyte-stimulating hormone (α-MSH) levels in the serum of patients with craniocerebral trauma. Forty-eight patients with acute craniocerebral injury were selected between January 2015 and October 2016. The patients were divided into three groups: severe (18 cases), moderate (16 cases) and mild (14 cases), according to the Glasgow Coma Scale (GCS) score at the time of admission. At the same time, 10 adults with a similar age distribution to the patients were also selected as a control group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28921600/injury-patterns-sustained-in-fatal-motor-vehicle-collisions-with-driver-s-third-generation-airbag-deployment
#6
Mariya Kuk, Michael J Shkrum
The Office of the Chief Coroner for Ontario database for 2011-2012 was used to compare fatal injury patterns in drivers whose third-generation airbags deployed compared to first- and second-generation airbag deployments and airbag nondeployments with and without seatbelt use. There were 110 frontal and offset frontal crashes analyzed. The small sample size meant that the odds of craniocerebral, cervical spinal, thoracic, and abdominal injuries were not statistically different for airbag generation, deployment status, and seatbelt use; however, the risk of fatal thoracic injuries in third- and second-generation cases was increased...
September 15, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28884730/-pharmacological-effects-and-clinical-application-of-pantogam-and-pantogam-active
#7
T A Voronina, S A Litvinova
Clinical studies and experience in the use of pantogam (hopanthenic acid) and pantogam active (rac-gopantenic/D-, L-gopantenic acid) showed their efficacy and safety in patients with various pathologies. Pantogam has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal syndrome. Pantogam active, having also an additional anxiolytic effect, is characterized by bimodal activity, improves not only cognitive functions, but also emotional state in patients in psychiatric, neurological and cardiological practice with such diseases and conditions as anxiety/anxiety-depressive disorders, chronic brain ischemia, ischemic heart disease, chronic heart failure, arterial hypertension, epilepsy, craniocerebral trauma, schizophrenia as well as cognitive impairment in the structure of neurological and psychogenic deficiencies...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28810347/-history-of-world-neurosurgery
#8
X Wang
In 5000 BC, South American tribes digged the bones in the living head to seek ways to communicate with the gods, which was primitive trephination and may be the first neurosurgical behavior. In 2600 BC, Imhotep in ancient Egypt took the brain out of the head from the nose, for a better preserve of the mummy, which was a prototype of modern transsphenoidal surgery. And the development of anatomy in ancient Greek laid a solid foundation for neurosurgery. From 500 to 1500 AD, the rise of religion and the occurrence of war, prompted a large number of craniocerebral trauma, which contributed greatly to the early development of neurosurgery as a distinct specialty...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28671080/targeted-surveillance-and-infection-related-risk-factors-of-nosocomial-infection-in-patients-after-neurosurgical-operation
#9
Lixi Jiang, Linping Guo, Rentao Li, Suzhen Wang
The purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. A total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and the distribution of pathogens, we investigated the infection-related risk factors...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28383154/the-forensic-implications-of-amphetamine-intoxication-in-cases-of-inflicted-blunt-craniocerebral-trauma
#10
Roger W Byard, James Donkin, Robert Vink
The effects of D-amphetamine on outcome after blunt craniocerebral trauma are characterized and the potential legal implications discussed. Traumatic brain injury (TBI) was induced under general anesthesia in adult, male Sprague Dawley rats using the impact acceleration model. At 10 min prior to injury, D-amphetamine (5 mg/kg) or saline vehicle was administered subcutaneously; animals were subsequently assessed over a 7-day period post-trauma for motor outcome using a rotarod device. D-amphetamine treated animals performed significantly better (p < 0...
April 6, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230652/a-case-of-postmortem-canine-depredation
#11
Dennis J Chute, Robert J Bready
We report the case of postmortem animal depredation that produced initial confusion for investigators who responded to the scene. A decomposing elderly woman was found in her presumed home with bilateral upper extremity amputations and craniocerebral trauma. This raised suspicion of foul play. Subsequent investigations together with autopsy led the medical examiner to conclude that the cause of death was natural disease and that those injuries found on her body were produced by at least one of the dogs who shared the premises...
June 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28168702/biparietal-thinning-accidental-death-by-a-fall-from-standing-height
#12
Robert W Mann, Masahiko Kobayashi, Alan L Schiller
Biparietal thinning resulting in bilateral and symmetrical resorption and loss of thickness of the parietal bones is an uncommon to rare condition in the anthropological and clinical literature. This enigmatic condition of unknown etiology was first reported in the 18th century and has been variously described as a nonmetric trait, anatomical variant, anomaly, and pathology. Biparietal thinning presents grossly and radiographically as oval-shaped depressions in 0.25-0.8% and 0.4-0.5% of individuals and with a higher frequency in females over the age of 60 years...
September 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28156135/pituitary-gland-trauma-in-fatal-nonsurgical-closed-traumatic-brain-injury
#13
Olufemi Emmanuel Idowu, John O Obafunwa, Sunday O Soyemi
BACKGROUND: Traumatic injury to pituitary gland can lead to significant endocrine dysfunctions. The aim of this study is to define the frequency of pituitary gland injury in patients with fatal nonsurgical closed traumatic brain injury (TBI), and to correlate if any, the type of craniocerebral injury associated with the pituitary gland injury. METHODS: The study is a prospective autopsy review of 30 adult patients with fatal closed TBI. Patients who had any form of neurosurgical intervention were excluded from the study...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27920935/cerebral-foreign-body-granuloma-in-brain-triggering-generalized-seizures-without-obvious-craniocerebral-injury-a-case-report-and-review-of-the-literature
#14
Nina Brawanski, Peter Baumgarten, Jürgen Konczalla, Volker Seifert, Christian Senft
BACKGROUND: Intracerebral foreign body granuloma is rarely reported. We present the case of a male patient with a cerebral foreign body granuloma. CASE DESCRIPTION: Initial admission of a 67-year-old male patient was after an aphasia followed by secondary generalized seizures. Cranial computed tomography (CCT) showed a metal-dense, wedge-shaped foreign body in the range of the frontal sinus on the left side, breaking through the frontal sinus, and creating a connection to the frontal cerebral lobe...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27837166/an-unusual-lethal-gunshot-wound-to-the-head
#15
Elmas Shaqiri, Bledar Xhemali, Zija Ismaili, Admir Sinamati, Gentian Vyshka
Atypical gunshot wounds present a challenge for the forensic expert, and sometimes differentiating these from a blunt trauma can be difficult. A careful crime scene investigation can be helpful in finding additional evidence and clarifying the nature of the injuries. We describe a case of an unusual craniocerebral injury that was initially interpreted as a blow from a wooden object. The appearance of the wound lacked the classical characteristics of entrance and exit bullet wounds, but the investigation showed it was due to the ricocheting of a destabilized bullet...
March 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/27693962/effects-of-activin-a-and-its-downstream-erk1-2-in-oxygen-and-glucose-deprivation-after-isoflurane-induced-postconditioning
#16
Qin Wang, Jiangwen Yin, Sheng Wang, Di Cui, Hong Lin, Mingyue Ge, Zhigang Dai, Liping Xie, Junqiang Si, Ketao Ma, Li Li, Lei Zhao
BACKGROUND: Isoflurane postconditioning (ISPOC) plays a neuroprotection role in the brain. Previous studies confirmed that isoflurane postconditioning can provide better protection than preconditioning in acute hypoxic-ischemic brain damage, such as acute craniocerebral trauma and ischemic stroke. Numerous studies have reported that activin A can protect rat's brain from cell injury. However, whether activin A and its downstream ERK1/2 were involved in isoflurane postconditioning-induced neuroprotection is unknown...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#17
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
March 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27571172/traumatic-brain-injury-due-to-screwdriver-assaults-literature-review-and-case-report
#18
REVIEW
Pavlos Pavlidis, Maria-Valeria Karakasi, Theodossios A Birbilis
Penetrating head injuries due to the use of screwdrivers as wounding agents in acts of interpersonal violence seldom occur. The aim of this article is to update and summarize the relevant literature on penetrating craniocerebral screwdriver stab wounds and to report a new case of screwdriver assault. A number of studies were reviewed to investigate the incidence, distribution, common findings, mechanism of injury, differential diagnostic criteria, complications, treatment, and prognosis of craniocerebral screwdriver stab injuries...
December 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27514081/-peculiarities-of-course-of-traumatic-disease-in-the-injured-persons-in-combined-cranioabdominal-trauma
#19
Ya L Zarutskyi, A E Tkachenko
Prospective investigation of the traumatic disease course was conducted in 71 injured persons, suffering a combined cranioabdominal trauma with the objective to determine the main functional systems and dynamics of their state severity. The occurrence rate and the severity degree of cardiovascular insufficiency were determined--in accordance to indices of the integrative body rheography and integrative dual frequency impedansometry, respiratory insufficiency (PaO₂/FiO₂ ratio), the organ insufficiency severity (in accordance to SOFA scale)...
March 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/27450528/differences-in-cognitive-function-of-rats-with-traumatic-brain-injuries-following-hyperbaric-oxygen-therapy
#20
Xiaonian Zhang, Xiaoyan Wang, Xinting Sun, Xiaojing Sun, Yue Zhang, Hao Zhang
BACKGROUND Hyperbaric oxygen (HBO) is a historical therapeutic option in the treatment of various types of brain damage. At present, clinical treatment of hypoxic-ischemic injury is giving priority to cognitive training. The effects of HBO on cognitive dysfunction were observed in a controlled cortical impact (CCI) rat model. MATERIAL AND METHODS Seventy male SD rats were randomly divided into control (n=10) and intervention (n=60) groups. All rats underwent baseline water maze testing 1 day before modeling, and were retested 8 weeks after modeling...
July 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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