Xu Chen, Manli Miao, Meng Zhou, Jie Chen, Dapeng Li, Ling Zhang, Anjiang Sun, Minglong Guan, Zixi Wang, Ping Liu, Shengquan Zhang, Xiaojun Zha, Xiaoyun Fan
Angiogenesis is a key characteristic of asthma airway remodeling. By releasing cationic granule proteins, such as major basic protein (MBP), activated eosinophils play a prominent role in asthma, but the underlying mechanisms are still not fully understood. In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP. Elevated FGFBP1 expression was also detected in asthma clinical samples, as well as in ovalbumin (OVA)-induced chronic asthma mouse models...
August 2, 2021: Cell Death & Disease