keyword
https://read.qxmd.com/read/34414693/natural-melanin-alginate-hydrogels-achieve-cardiac-repair-through-ros-scavenging-and-macrophage-polarization
#21
JOURNAL ARTICLE
Jin Zhou, Wei Liu, Xiaoyi Zhao, Yifan Xian, Wei Wu, Xiao Zhang, Nana Zhao, Fu-Jian Xu, Changyong Wang
The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is greatly limited by the cardiac microenvironment. The combination of reactive oxygen species (ROS) scavenging to suppress the oxidative stress damage and macrophage polarization to regenerative M2 phenotype in the MI microenvironment can be desirable for MI treatment. Herein, melanin nanoparticles (MNPs)/alginate (Alg) hydrogels composed of two marine-derived natural biomaterials, MNPs obtained from cuttlefish ink and alginate extracted from ocean algae, are proposed...
August 19, 2021: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/34346184/facile-polyphenol-europium-assembly-enabled-functional-poly-l-lactic-acid-nanofiber-mats-with-enhanced-antioxidation-and-angiogenesis-for-accelerated-wound-healing
#22
JOURNAL ARTICLE
Keke Wu, Xiaoxian Wu, Jinshan Guo, Yanpeng Jiao, Changren Zhou
Burns, trauma, surgery and chronic diabetic ulcers are the most common reasons causing skin wounds in clinic. Thus, developing a functional wound dressing has been an imperative issue. Herein, functional wound dressing (poly(l-lactic acid) PLLA-((tanic acid (TA)/europium (Eu))n ) is fabricated through a facile polyphenol-europium ion assembly to ameliorate wound microenvironment via scavenging excessive reactive oxygen species (ROS) and promoting angiogenesis. The physicochemical characterization indicates that the multicycle assembled TA/Eu is uniformly deposited on PLLA-(TA/Eu)n nanofiber mats surface...
August 4, 2021: Advanced Healthcare Materials
https://read.qxmd.com/read/34341336/poly-l-arginine-promotes-asthma-angiogenesis-through-induction-of-fgfbp1-in-airway-epithelial-cells-via-activation-of-the-mtorc1-stat3-pathway
#23
JOURNAL ARTICLE
Xu Chen, Manli Miao, Meng Zhou, Jie Chen, Dapeng Li, Ling Zhang, Anjiang Sun, Minglong Guan, Zixi Wang, Ping Liu, Shengquan Zhang, Xiaojun Zha, Xiaoyun Fan
Angiogenesis is a key characteristic of asthma airway remodeling. By releasing cationic granule proteins, such as major basic protein (MBP), activated eosinophils play a prominent role in asthma, but the underlying mechanisms are still not fully understood. In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP. Elevated FGFBP1 expression was also detected in asthma clinical samples, as well as in ovalbumin (OVA)-induced chronic asthma mouse models...
August 2, 2021: Cell Death & Disease
https://read.qxmd.com/read/34179086/the-inhibitory-effect-of-lysophosphatidylcholine-on-proangiogenesis-of-human-cd34-cells-derived-endothelial-progenitor-cells
#24
JOURNAL ARTICLE
Haijun Zhao, Yanhui He
Increasing evidence reveals that lysophosphatidylcholine (LPC) is closely related to endothelial dysfunction. The present study aimed to investigate the mechanism of LPC in inhibiting the proangiogenesis and vascular inflammation of human endothelial progenitor cells (EPCs) derived from CD34+ cells. The early EPCs were derived from CD34+ hematopoietic stem cells whose purity was identified using flow cytometry analysis. The surface markers (CD34, KDR, CD31; VE-cadherin, vWF, eNOS) of EPCs were examined by flow cytometry analysis and immunofluorescence...
2021: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/34162231/nrg1%C3%AE-neuregulin-1%C3%AE-as-a-proangiogenesis-therapy-how-is-nrg1%C3%AE-therapy-unique-from-other-angiogenesis-therapies
#25
EDITORIAL
Ying H Shen, Jun-Ichi Abe
No abstract text is available yet for this article.
June 24, 2021: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/34029951/notoginsenoside-r1-activates-the-nampt-nad-sirt1-cascade-to-promote-postischemic-angiogenesis-by-modulating-notch-signaling
#26
JOURNAL ARTICLE
Ting Zhu, Wei-Jie Xie, Lei Wang, Xin-Biao Jin, Xiang-Bao Meng, Gui-Bo Sun, Xiao-Bo Sun
Nicotinamide phosphoribosyltransferase (NAMPT) maintains mitochondrial function and protects against cerebral ischemic injury by improving energy metabolism. Notoginsenoside R1 (R1), a unique constituent of Panax notoginseng, has been shown to promote the proliferation and tube formation of human umbilical vein endothelial cells. Whether R1 has proangiogenesis on the activation of NAMPT in ischemic stroke remains unclear. The purpose of this study was to investigate the pharmacodynamic effect and mechanism of R1 on angiogenesis after ischemic stroke...
August 2021: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/33953789/a-network-pharmacology-approach-to-predict-the-proangiogenesis-mechanism-of-huangqi-honghua-herb-pair-after-cerebral-ischemia
#27
JOURNAL ARTICLE
Jinyi Cao, Lu Lei, Kai Wang, Jing Sun, Yi Qiao, Jialin Duan, Chao Zhao, Jia Cui, Zhijun Feng, Jing-Wen Wang, Aidong Wen, Zhifu Yang
Objective: Huangqi-Honghua herb pair is known for its medicinal value to treat Qi deficiency and blood stasis syndrome with a long history in clinical practice. To understand its possible mechanism in a systematic study, a network pharmacological method was addressed. Methods: Detailed information on the HH compounds was obtained from two public databases, and oral bioavailability (OB) and drug-like (DL) of the compounds were evaluated. A correlation between HH compounds, its potential targets, and known targets was extrapolated, and the herb-compound-target-disease (H-C-T-D) network was established...
2021: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/33415855/-effects-of-electroacupuncture-on-proangiogenesis-process-and-protein-turnover-in-a-mouse-model-of-sarcopenia
#28
JOURNAL ARTICLE
Zheng-Wei Zhu, Cheng-Lin Tang, Xiao-Hong Li, Zhi-Xue Yang, Yun-Hao Yang, Fang Pang, Dong-Mei Liao, Xiao Guo
OBJECTIVE: To observe the effect of electroacupuncture(EA) on proangiogenesis process and protein turn-over in a mouse model of sarcopenia, so as to explore its potential molecular mechanism anti-aging. METHODS: Fourteen 30-week-old male SAMP8 mice were randomly divided into a model group ( n =7) and an EA group ( n =7). Seven anti-rapidly aging SAMR1 mice of the same age were used as the control group ( n =7). EA (1 mA, 4 Hz) was applied to bilateral "Zusanli"(ST36) and "Yanglingquan"(GB34) for 20 minutes each time once a day, 6 times a week for 4 weeks...
December 25, 2020: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/33213517/human-adipose-derived-stem-cells-enriched-with-vegf-modified-mrna-promote-angiogenesis-and-long-term-graft-survival-in-a-fat-graft-transplantation-model
#29
JOURNAL ARTICLE
Fei Yu, Nevin Witman, Dan Yan, Siyi Zhang, Meng Zhou, Yan Yan, Qinke Yao, Feixue Ding, Bingqian Yan, Huijing Wang, Wei Fu, Yang Lu, Yao Fu
BACKGROUND: Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted therapy to improve graft survival. As free-living fat requires nutritional and respiratory sources to thrive, insufficient and unstable vascularization still impedes hADSC-assisted therapy. Recently, cytotherapy combined with modified mRNA (modRNA) encoding vascular endothelial growth factor (VEGF) has been applied for the treatment of ischemia-related diseases...
November 19, 2020: Stem Cell Research & Therapy
https://read.qxmd.com/read/33051984/citronellal-ameliorates-doxorubicin-induced-hepatotoxicity-via-antioxidative-stress-antiapoptosis-and-proangiogenesis-in-rats
#30
JOURNAL ARTICLE
Xu Liu, Yue Qiu, Yanhua Liu, Ning Huang, Cai Hua, Qianqian Wang, Zeqing Wu, Junxiu Lu, Ping Song, Jian Xu, Peng Li, Yaling Yin
Doxorubicin (DOX) is a very effective broad-spectrum anticancer drug, yet its clinical application is badly restricted due to its serious side effects. Citronellal (CT), a specialized metabolite of plants found in Cymbopogon spp., is proved to exhibit many beneficial properties. In the current study, we intended to investigate the effect of CT on DOX-induced hepatotoxicity in rats. Rats were treated with CT (200 mg/kg b.w./day orally), and given DOX (2.5 mg/kg b.w./week, intraperitoneally) to induce hepatotoxicity for six consecutive weeks...
October 13, 2020: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/32495458/discovery-and-identification-of-proangiogenic-chemical-markers-from-gastrodiae-rhizoma-based-on-zebrafish-model-and-metabolomics-approach
#31
JOURNAL ARTICLE
Mengyujie Liu, Liang Zhao, Liwen Han, Haonan Li, Yongping Shi, Jing Cui, Chenyang Wang, Li Xu, Lihong Zhong
INTRODUCTION: Angiogenesis is closely related to a variety of diseases, and therapies based on angiogenesis are intensely investigated. Studies have shown that the use of Gastrodiae Rhizoma (GR, Gastrodia elata) can benefit the treatment of ischemic cardiovascular diseases and atherosclerosis by stimulating angiogenesis. OBJECTIVE: This study tested the angiogenesis effects of a group of chemical markers isolated from GR. MATERIAL AND METHODS: Zebrafish model was used to evaluate angiogenesis by setting four groups: blank control group, model group, positive control group and treatment group (0...
June 3, 2020: Phytochemical Analysis: PCA
https://read.qxmd.com/read/32117933/interactions-of-alginate-deferoxamine-conjugates-with-blood-components-and-their-antioxidation-in-the-hemoglobin-oxidation-model
#32
JOURNAL ARTICLE
Tong Sun, Xi Guo, Rui Zhong, Chengwei Wang, Hao Liu, Hao Li, Lu Ma, Junwen Guan, Chao You, Meng Tian
While deferoxamine (DFO) has long been used as an FDA-approved iron chelator, its proangiogenesis ability attracts increasing number of research interests. To address its drawbacks such as short plasma half-life and toxicity, polymeric conjugated strategy has been proposed and shown superiority. Owing to intravenous injection and application in blood-related conditions, however, the blood interactions and antioxidation of the DFO-conjugates and the mechanisms underlying these outcomes remain to be elucidated...
2020: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/32004612/fucoidan-from-laminaria-japonica-exerts-antitumor-effects-on-angiogenesis-and-micrometastasis-in-triple-negative-breast-cancer-cells
#33
JOURNAL ARTICLE
Wen-Jing Hsu, Mei-Hsiang Lin, Tai-Chih Kuo, Chih-Ming Chou, Fwu-Long Mi, Chia-Hsiung Cheng, Cheng-Wei Lin
Fucoidan is a fucose-rich polysaccharide that has gained attention for its various anticancer properties. However, the effect and underlying mechanism of fucoidan on triple-negative breast cancer (TNBC) are still unknown. Herein, we investigated the anticancer potential of fucoidan from Laminaria japonica. We found that fucoidan showed modest antiproliferative activity against TNBC cells, while it effectively reduced migratory and invasive capacities. Mechanistically, fucoidan suppressed activation of MAPK and PI3K followed by inhibition of AP-1 and NF-κB signaling in TNBC...
April 15, 2020: International Journal of Biological Macromolecules
https://read.qxmd.com/read/31985636/noncontact-phased-array-ultrasound-facilitates-acute-wound-healing-in-mice
#34
JOURNAL ARTICLE
Nao Wakabayashi, Atsushi Sakai, Hiroya Takada, Takayuki Hoshi, Hitomi Sano, Shizuko Ichinose, Hidenori Suzuki, Rei Ogawa
BACKGROUND: The authors developed a noncontact low-frequency ultrasound device that delivers high-intensity mechanical force based on phased-array technology. It may aid wound healing because it is likely to be associated with lower risks of infection and heat-induced pain compared with conventional ultrasound methods. The authors hypothesized that the microdeformation it induces accelerates wound epithelialization. Its effects on key wound-healing processes (angiogenesis, collagen accumulation, and angiogenesis-related gene transcription) were also examined...
February 2020: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/31790075/noncontact-phased-array-ultrasound-facilitates-acute-wound-healing-in-mice
#35
JOURNAL ARTICLE
Nao Wakabayashi, Atsushi Sakai, Hiroya Takada, Takayuki Hoshi, Hitomi Sano, Shizuko Ichinose, Hidenori Suzuki, Rei Ogawa
BACKGROUND: We developed a noncontact low-frequency ultrasound device that delivers high-intensity mechanical force based on phased-array (PA) technology (NLFU-PA). It may aid wound healing because it is likely to associate with lower risks of infection and heat-induced pain than conventional ultrasound methods. We hypothesized that the microdeformation it induces accelerates wound epithelialization. This was tested in mice. Its effects on key wound-healing processes, namely, angiogenesis, collagen accumulation, and angiogenesis-related gene transcription, were also examined...
November 19, 2019: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/31741991/correlation-between-%C3%AE-catenin-expression-and-staging-in-nasopharyngeal-carcinoma-patients
#36
JOURNAL ARTICLE
Fransisca Ira Amelia, Muhtarum Yusuf, Artono
Nasopharyngeal carcinoma (NPC) is a malignant disease derived from nasopharyngeal epithelial cells that have a higher tendency for invasion and metastasis to the cervical lymph nodes than other head-neck malignancies. NPC patients with the same stages often show different progressions and prognoses. This suggests that clinical stages are not sufficient to predict progressivity, so biomarkers are required to provide better progression predictions. Some literature shows that the development and progression of NPC is a complex mechanism involving various components of signal paths, it plays a role in regulating the process of proliferation, angiogenesis and apoptosis...
October 2019: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/31609010/mir-152-lin28b-axis-modulates-high-glucose-induced-angiogenesis-in-human-retinal-endothelial-cells-via-vegf-signaling
#37
JOURNAL ARTICLE
Xiaolin Fu, Bo Ou
Diabetic retinopathy (DR) is a serious complication of diabetes contributing to blindness in patients. Inhibiting retinal neovascularization is a potent strategy for diabetic retinopathy treatment. Reportedly, the stable expression of lin-28 homolog B (LIN28B), a member of the highly conserved RNA-binding protein LIN28 family, could promote vascular endothelial growth factor (VEGF) expression; herein, we investigated the role and mechanism of LIN28B in diabetic retinopathy progression from the perspective of microRNA (miRNA) regulation...
October 14, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/31595890/angiogenesis-promoted-bone-repair-with-silicate-shelled-hydrogel-fiber-scaffolds
#38
JOURNAL ARTICLE
Khandmaa Dashnyam, Jennifer O Buitrago, Tsendmaa Bold, Nandin Mandakhbayar, Roman A Perez, Jonathan C Knowles, Jung-Hwan Lee, Hae-Won Kim
Promoting angiogenesis is a key strategy for stimulating the repair of damaged tissues, including bone. Among other proangiogenic factors, ions have recently been considered a potent element that can be incorporated into biomaterials and then released at therapeutic doses. Silicate-based biomaterials have been reported to induce neovascularization through vascular endothelial growth factor signaling pathway, potentiating acceleration of bone regeneration. Here, we designed a silicate-shelled hydrogel fiber scaffold with a hard/soft layered structure to investigate the possibility of silicate coating on biopolymer for enhancing biological properties...
November 19, 2019: Biomaterials Science
https://read.qxmd.com/read/31370258/new-insight-into-therapies-targeting-angiogenesis-in-hepatocellular-carcinoma
#39
REVIEW
Monica Mossenta, Davide Busato, Lorena Baboci, Federica Di Cintio, Giuseppe Toffoli, Michele Dal Bo
Hepatocellular carcinoma (HCC) is a malignancy characterized by neoangiogenesis that is determined by an augmented production of proangiogenesis factors by tumor and adjacent cells. This unbalanced angiogenesis process is a key feature of HCC carcinogenesis and progression. Proangiogenic factors also have a relevant role in the generation and maintenance of an immunosuppressive tumor microenvironment. Several therapeutic options for HCC treatment are based on the inhibition of angiogenesis, both in the early/intermediate stages of the disease and in the late stages of the disease...
July 31, 2019: Cancers
https://read.qxmd.com/read/31320911/effects-of-curcumin-on-vessel-formation-insight-into-the-pro-and-antiangiogenesis-of-curcumin
#40
REVIEW
Ting-Ye Wang, Jia-Xu Chen
Curcumin is a compound extracted from the Curcuma longa L, which possesses a wide range of pharmacological effects. However, few studies have collected scientific evidence on its dual effect on angiogenesis. The present review gathered the fragmented information available in the literature to discuss the dual effect and possible mechanisms of curcumin on angiogenesis. Available information concerning the effect of curcumin on angiogenesis is compiled from scientific databases, including PubMed and Web of Science using the key term (curcumin and angiogenesis)...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
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