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Zhengfeng Wang, Ruihua Wang, Kai Wang, Xianzhi Liu
Angiogenesis after ischemic stroke have important clinical significance, which stimulates endogenous recovery mechanisms and improves the neurological outcome. Enhancing angiogenesis may facilitate the function recovery from ischemic stroke. Recent studies have shown that aberrant expression of long non-coding RNAs (lncRNAs) is related to angiogenesis after ischemic stroke. Snhg1, a cancer-related lncRNA, has been reported to be upregulated after stroke. However, little is known about its role in stroke. In this study, we performed in vitro experiments to investigate the effects of Snhg1 on cell survival and angiogenesis and molecular mechanism in ischemic stroke...
June 8, 2018: Canadian Journal of Physiology and Pharmacology
Carlos Zgheib, Maggie M Hodges, Myron W Allukian, Junwang Xu, Kara L Spiller, Joseph H Gorman, Robert C Gorman, Kenneth W Liechty
BACKGROUND: In contrast to adults, the fetal response to myocardial infarction (MI) is regenerative, requiring the recruitment of cardiac progenitor cells to replace infarcted myocardium. Macrophage contribution to tissue repair depends on their phenotype: M1 are proinflammatory and initiate angiogenesis; M2a are profibrotic and contribute to blood vessels maturation; and M2c are proremodeling and proangiogenesis. The goal of the present study was to expand on this work by examining cardiac progenitor cells recruitment, and the role of macrophages in promoting angiogenesis and cardiac regeneration in the fetal heart after MI...
December 2017: Annals of Thoracic Surgery
Xialian Xu, Nana Song, Xue Zhang, Xiaoyan Jiao, Jiachang Hu, Mingyu Liang, Jie Teng, Xiaoqiang Ding
BACKGROUND: Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS: To stabilize HIF-1α, hypoxia (1% O2 for 24 hours) was performed in human umbilical vein endothelial cells and cobalt chloride (CoCl2) was pretreated intraperitoneally 24 hours before renal I/R in mice...
August 2017: Transplantation
Wenwei Guo, Liang Fang, Bo Li, Xifeng Xiao, Shuqiang Chen, Jun Wang, Fang Yang, Lihua Chen, Xiaohong Wang
Human leukocyte antigen (HLA)-G plays a crucial role in conferring fetal-maternal tolerance and ensuring a successful pregnancy. CD56(bright) natural killer (NK) cells accumulate at the maternal decidua in large numbers during pregnancy and are found in direct contact with fetal trophoblasts. There are increasing evidences that decidual NK (dNK) cells are crucial for pregnancy. However, the regulation of dNK cells is mostly unknown. Here, we provide evidences that the secretion function of dNK cells in recurrent spontaneous abortion was impaired, which led to the impairment of the proinvasion and proangiogenesis functions of dNK cells...
2017: Frontiers in Immunology
Shuangshuang Li, Li Li, Chengrui Guo, Huanhuan Qin, Xixun Yu
Effectively stimulating angiogenesis is great challenge in wound care management. It's necessary to develop a new wound dressing with angiogenic capacity. Therefore, strontium loaded SF/SA blend films were prepared as a potential wound dressing material, and their physicochemical and bioactive properties were evaluated. The strontium loaded SF/SA blend films (especially the strontium loaded SF/SA blend films prepared by treating with 5mg/ml Sir solution) could meet the needs of a wound dressing such as water absorption, water vapor transmission rate, mechanical properties and fibroblasts-cytocompatibility...
November 2017: International Journal of Biological Macromolecules
Leila Chodari, Mustafa Mohammadi, Gisou Mohaddes, Mohammad Reza Alipour, Vajiheh Ghorbanzade, Hassan Dariushnejad, Shima Mohammadi
BACKGROUND: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play important role during capillary-like network formation in angiogenesis process. OBJECTIVES: To determine the effects of testosterone and voluntary exercise on levels of vascularity, phosphorylated Akt (P- AKT) and phosphorylated ERK (P-ERK) in heart tissue of diabetic and castrated diabetic rats...
December 2016: Arquivos Brasileiros de Cardiologia
Meng Xie, Dafydd Alwyn Dart, Ting Guo, Xiao-Fang Xing, Xiao-Jing Cheng, Hong Du, Wen G Jiang, Xian-Zi Wen, Jia-Fu Ji
BACKGROUND: We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. Here we aim to elucidate the role of miR-1 in gastric carcinogenesis. METHODS: We measured miR-1 expression in human GC cell lines and 90 paired primary GC samples, and analyzed the association of its status with clinicopathological features. The effect of miR-1 on GC cells was evaluated by proliferation and migration assay...
January 2018: Gastric Cancer
Wang Shiying, Sun Boyun, Yuan Jianye, Zhang Wanjun, Tao Ping, Lin Jiang, Hu Hongyi
The effects of VEGFA isoforms on the vascular permeability and structure are still unclear. In this study, we found that VEGFA121 and VEGFA165, 2 isoforms of VEGFA, exerted the opposing effects of antiangiogenesis and proangiogenesis on regulating vascular endothelia cells proliferation and tube formation. The 2 isoforms affected the protein expression of Ras-related protein 1-GTPase-activating protein 1 (Rap1GAP) and thrombospondin 1, 2 important signal molecules of Rap1GAP/thrombospondin 1 signal pathway in primary human umbilical vein endothelial cells by regulating 2 different phosphorylating sites of VEGFR2, Tyr(1175) and Tyr(1214)...
April 2017: Inflammatory Bowel Diseases
Yusuke Hirayama, Ryosuke Nakanishi, Noriaki Maeshige, Hidemi Fujino
Physical inactivity leads to muscle atrophy and capillary regression in the skeletal muscle. Intermittent loading during hindlimb unloading attenuates the muscle atrophy, meanwhile the capillary regression in the skeletal muscle is not suppressed. Nucleoprotein has antioxidant capacity and may prevent capillary regression. Therefore, we assessed the combined effects of intermittent loading with nucleoprotein supplementation on capillary regression induced by hindlimb unloading. Five groups of rats were assigned: control (CON), 7 days hindlimb unloading (HU), HU plus nucleoprotein supplementation (HU + NP), intermittent loading during HU (HU + IL), and intermittent loading combined with nucleoprotein supplementation during HU (HU + IL + NP)...
February 2017: Physiological Reports
Shih-Ya Tseng, Ting-Hsing Chao, Yi-Heng Li, Chung-Lung Cho
This study investigated the effect of cilostazol on proangiogenesis functions in human early endothelial progenitor cells (EPCs) in vitro and the therapeutic implication of hybrid therapy with cilostazol and human early EPCs in vivo. Cilostazol significantly increased colony-forming units and enhanced differentiation of EPCs toward endothelial lineage. Treatments resulted in antiapoptotic effects and stimulated proliferation and migration and in vitro vascular tube formation through activation of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4)/phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway...
2016: BioMed Research International
Hua Liu, Zhongkun Liu, Yong Liu, Shifeng Kan, Jian Yang, Hongyi Liu
OBJECTIVE Chronic subdural hematoma (CSDH) is prevalent in the aged population and is commonly treated with bur hole drainage. This treatment, however, can lead to various surgical complications. Atorvastatin may cure CSDH via its antiinflammatory and proangiogenesis effects, but not all patients treated with this medication can avoid surgery. The authors' aim was to investigate the effect of atorvastatin and identify characteristics of patients with CSDH sensitive to atorvastatin therapy. METHODS A prospective, placebo-controlled observational study was conducted in 80 patients with evidence of CSDH...
July 29, 2016: Journal of Neurosurgery
Leila Chodari, Mustafa Mohammadi, Vajiheh Ghorbanzadeh, Hassan Dariushnejad, Gisou Mohaddes
OBJECTIVES: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. This study was aimed to evaluate the effects of testosterone and voluntary exercise on vascular endothelial growth factor-A (VEGF-A), stromal cell-derived factor 1a (SDF-1a) and myocardial capillary density in heart of rats with diabetes. METHODS: Type 1 diabetes was induced by intraperitoneal injection of 55 mg/kg of streptozotocin in 80 male Wistar rats. After 42 days of treatment with testosterone (2 mg/kg/day) or voluntary exercise alone or in combination, angiogenesis was determined in the hearts by immunostaining for PECAM-1/CD31...
October 2016: Canadian Journal of Diabetes
Haishan Zhao, Olivia J Osborne, Sijie Lin, Zhaoxia Ji, Robert Damoiseux, Yuqiang Wang, André E Nel, Shuo Lin
Recent studies suggest that the nanorods consisting of europium hydroxide could promote angiogenesis. In this study, it is sought to determine if additional types of nanoparticles are capable of enhancing angiogenesis and in addition, understand the underlying mechanisms. For this reason, a method is employed that combines a high throughput in vitro cell based screen coupled with an in vivo validation using vascular specific green fluorescent protein reporter transgenic zebrafish for examining proangiogenesis activity...
August 2016: Small
Xiaoping Zhang, Weishuai Lian, Wensheng Lou, Shilong Han, Chenhui Lu, Keqiang Zuo, Haobo Su, Jichong Xu, Chuanwu Cao, Tao Tang, Zhongzhi Jia, Tao Jin, Georges Uzan, Jianping Gu, Maoquan Li
Microvascular lesion in diabetic peripheral arterial disease (PAD) still cannot be resolved by current surgical and interventional technique. Endothelial cells have the therapeutic potential to cure microvascular lesion. To evaluate the efficacy and immune-regulatory impact of intra-arterial infusion of autologous CD133(+) cells, we recruited 53 patients with diabetic PAD (27 of CD133(+) group and 26 of control group). CD133(+) cells enriched from patients' PB-MNCs were reinfused intra-arterially. The ulcer healing followed up till 18 months was 100% (3/3) in CD133(+) group and 60% (3/5) in control group...
2016: Stem Cells International
Jinyan Li, Dong Zhai, Fang Lv, Qingqing Yu, Hongshi Ma, Jinbo Yin, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu
UNLABELLED: Effectively stimulating angiogenesis and avoiding wound infection are great challenges in wound care management. Designing new healing dressings with requisite angiogenic capacity and antibacterial performance is of particular significance. In order to achieve this aim, we prepared a copper (Cu)-containing bioactive glass nanocoating (40-50nm) with uniform nanostructure on natural eggshell membrane (Cu-BG/ESM) by the pulsed laser deposition (PLD) technique. The surface physicochemical properties including hydrophilicity and hardness of ESM were significantly improved after depositing Cu-BG nanocoatings...
May 2016: Acta Biomaterialia
Ting Kang, Tia M Jones, Clayton Naddell, Methode Bacanamwo, John W Calvert, Winston E Thompson, Vincent C Bond, Y Eugene Chen, Dong Liu
UNLABELLED: Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of this study was to explore the potential effects of stem cell-released MVs in proangiogenic therapy. We observed for the first time that MVs were released from adipose-derived stem cells (ASCs) and were able to increase the migration and tube formation of human umbilical vein endothelial cells (HUVECs)...
April 2016: Stem Cells Translational Medicine
Shang Li, Yuanye Dang, Xuelin Zhou, Bin Huang, Xiaohui Huang, Zherui Zhang, Yiu Wa Kwan, Shun Wan Chan, George Pak Heng Leung, Simon Ming Yuen Lee, Maggie Pui Man Hoi
Formononetin is an isoflavone that has been shown to display estrogenic properties and induce angiogenesis activities. However, the interrelationship between the estrogenic properties and angiogenesis activities of formononetin are not well defined. In the present study, docking and enzymatic assay demonstrated that formononetin displayed direct binding to the ligand-binding domain (LBD) of estrogen receptor alpha (ERα) with an agonistic property. Results from Human Umbilical Vein Endothelial Cells (HUVEC) by using real-time migration xCELLigence system, immunofluorescence and western blotting provided strong evidences of formononetin induced endothelial cell migration and dramatic actin cytoskeleton spatial modification through ERα-enhanced-ROCK-II/MMP2/9 signaling pathways...
November 16, 2015: Scientific Reports
Feng Wu, Zhiqing He, Ru Ding, Zhigang Huang, Qixia Jiang, Haiming Cui, Yi Lin, Shuaibo Huang, Xianliang Dai, Jiayou Zhang, Zonggui Wu, Chun Liang
The aim of this paper is to investigate effect and mechanism of Danhong injection (DH) on angiogenesis in the diabetic hind limb ischemia mouse model. Thirty diabetic hind limb ischemic model mice and ten normal mice, established by intraperitoneal (i.p.) injection of streptozotocin (STZ) or PBS and ligation/excision of femoral artery, and then twenty diabetic hind limb ischemic model mice of all were evenly randomized to saline (control, n = 10) and DH i.p. injection (2 mL/kg weight for 7 days, n = 10) groups...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Chen Chen, Dao Wen Wang
Arachidonic acids are converted to eicosanoid mediators by different enzyme systems: cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) monooxygenase pathways (ω/ω-1-hydroxylases and epoxygenases). Of 57 putatively functional human CYPs, only about a dozen enzymes are responsible for xenobiotic metabolism. CYP2 family is the predominant epoxygenase isoform abundantly expressed in the endothelium, myocardium, and kidney in humans. Numerous studies have demonstrated the cardiovascular protective effects of CYP epoxygenases and eicosatrienoic acids ranging from vasodilation, antihypertensive, proangiogenesis, antiatherosclerosis, and cardiac protection...
2015: Advances in Pharmacology
Ya-Dan Wen, Yi-Zhun Zhu
S-propargyl-cysteine (SPRC), also named as ZYZ-802, is a structural analog of S-allylcysteine (SAC), the most abundant constituent of aged garlic extract. SPRC becomes a derivative of the amino acid cysteine, which contains sulfur atom, by changing allyl group in SAC to propargyl group in SPRC. Another analog of SPRC and SAC is S-propyl cysteine (SPC), which has propyl group instead in its cysteine structure. Drug formulation of SPRC has been investigated in the mixture of extenders, such as lactose, microcrystalline cellulose, and cross-linked povidone, showing good fluidity and scale-up production possibility...
2015: Handbook of Experimental Pharmacology
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