Xiuxian Wei, Yi Li, Tao Jiang, Pengcheng Luo, Yue Dai, Qian Wang, Mulin Xu, Jinhua Yan, Yongjun Li, Jingwen Gao, Lei Liu, Cuntai Zhang, Yu Liu
Abdominal aortic aneurysm (AAA), a vascular degenerative disease, is a potentially life-threatening condition characterised by the loss of vascular smooth muscle cells (VSMCs), degradation of extracellular matrix (ECM), inflammation, and oxidative stress. Despite the severity of AAA, effective drugs for treatment are scarce. At low doses, terazosin (TZ) exerts antiapoptotic and anti-inflammatory effects in several diseases, but its potential to protect against AAA remains unexplored. Herein, we investigated the effects of TZ in two AAA animal models: Angiotensin II (Ang II) infusion in Apoe-/- mice and calcium chloride application in C57BL/6J mice...
February 6, 2024: European Journal of Pharmacology