keyword
https://read.qxmd.com/read/38391925/novel-glycomimetics-protect-against-glycated-low-density-lipoprotein-induced-vascular-calcification-in-vitro-via-attenuation-of-the-rage-erk-creb-pathway
#21
JOURNAL ARTICLE
Gary P Sidgwick, Ria Weston, Ayman M Mahmoud, Andrew Schiro, Ferdinand Serracino-Inglott, Shikha M Tandel, Sarah Skeoch, Ian N Bruce, Alan M Jones, M Yvonne Alexander, Fiona L Wilkinson
Heparan sulphate (HS) can act as a co-receptor on the cell surface and alterations in this process underpin many pathological conditions. We have previously described the usefulness of mimics of HS (glycomimetics) in protection against β-glycerophosphate-induced vascular calcification and in the restoration of the functional capacity of diabetic endothelial colony-forming cells in vitro. This study aims to investigate whether our novel glycomimetic compounds can attenuate glycated low-density lipoprotein (g-LDL)-induced calcification by inhibiting RAGE signalling within the context of critical limb ischemia (CLI)...
February 8, 2024: Cells
https://read.qxmd.com/read/38388918/vascular-smooth-muscle-cell-specific-igf1r-deficiency-exacerbates-the-development-of-hypertension-induced-cerebral-microhemorrhages-and-gait-defects
#22
JOURNAL ARTICLE
Lauren R Miller, Marisa A Bickel, Michaela L Vance, Hannah Vaden, Domonkos Nagykaldi, Adam Nyul-Toth, Elizabeth C Bullen, Tripti Gautam, Stefano Tarantini, Andriy Yabluchanskiy, Tamas Kiss, Zoltan Ungvari, Shannon M Conley
Cerebrovascular fragility and cerebral microhemorrhages (CMH) contribute to age-related cognitive impairment, mobility defects, and vascular cognitive impairment and dementia, impairing healthspan and reducing quality of life in the elderly. Insulin-like growth factor 1 (IGF-1) is a key vasoprotective growth factor that is reduced during aging. Circulating IGF-1 deficiency leads to the development of CMH and other signs of cerebrovascular dysfunction. Here our goal was to understand the contribution of IGF-1 signaling on vascular smooth muscle cells (VSMCs) to the development of CMH and associated gait defects...
February 23, 2024: GeroScience
https://read.qxmd.com/read/38387723/cannabidiol-protects-against-acute-aortic-dissection-by-inhibiting-macrophage-infiltration-and-pmaip1-induced-vascular-smooth-muscle-cell-apoptosis
#23
JOURNAL ARTICLE
Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Guo
Acute aortic dissection (AAD) progresses rapidly and is associated with high mortality; therefore, there remains an urgent need for pharmacological agents that can protect against AAD. Herein, we examined the therapeutic effects of cannabidiol (CBD) in AAD by establishing a suitable mouse model. In addition, we performed human AAD single-cell RNA sequencing and mouse AAD bulk RNA sequencing to elucidate the potential underlying mechanism of CBD. Pathological assays and in vitro studies were performed to verify the results of the bioinformatic analysis and explore the pharmacological function of CBD...
February 20, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38385175/-in-chronic-kidney-disease-altered-cardiac-metabolism-precedes-cardiac-hypertrophy
#24
JOURNAL ARTICLE
Matthew J Williams, Carmen M Halabi, Hiral M Patel, Zachary Joseph, Kyle McCommis, Carla Weinheimer, Attila Kovacs, Florence Lima, Brian Finck, Hartmut Malluche, Keith A Hruska
Conduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent...
February 22, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38383916/mettl3-mediated-m6a-modification-of-norad-inhibits-the-ferroptosis-of-vascular-smooth-muscle-cells-to-attenuate-the-aortic-dissection-progression-in-an-ythdf2-dependent-manner
#25
JOURNAL ARTICLE
Mingfang Liao, Sili Zou, Jianjin Wu, Jun Bai, Yandong Liu, Kangkang Zhi, Lefeng Qu
Ferroptosis of vascular smooth muscle cells (VSMCs) is related to the incidence of aortic dissection (AD). Long non-coding RNA (lncRNA) NORAD plays a crucial role in the progression of various diseases. The present study aimed to investigate the effects of NORAD on the ferroptosis of VSMCs and the molecular mechanisms. The expression of NORAD, HUR, and GPX4 was detected using quantitative real-time PCR (qPCR) or western blot. Ferroptosis was evaluated by detecting lactate dehydrogenase (LDH) activity, lipid reactive oxygen species (ROS), malonaldehyde (MDA) content, L-Glutathione (GSH) level, Fe2+ content, and ferroptosis-related protein levels...
February 22, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38382550/scutellarin-inhibits-oleic-acid-induced-vascular-smooth-muscle-foam-cell-formation-via-activating-autophagy-and-inhibiting-nlrp3-inflammasome-activation
#26
JOURNAL ARTICLE
Wen-Cong Gao, Tie-Hua Yang, Bin-Bao Wang, Qian Liu, Qing Li, Xiao-Huan Zhou, Chang-Bo Zheng, Peng Chen
Abnormalities in vascular smooth muscle cells (VSMCs) are pivotal in the pathogenesis of cardiovascular pathologies such as atherosclerosis and hypertension. Scutellarin (Scu), a flavonoid derived from marigold flowers, exhibits a spectrum of biological activities including anti-inflammatory, antioxidant, antitumor, immunomodulatory and antimicrobial effects. Notably, Scu has demonstrated the capacity to mitigate vascular endothelial damage and prevent atherosclerosis via its antioxidative properties. Nevertheless, the influence of Scu on the formation of VSMC-derived foam cells remains underexplored...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38378972/hsa_circ_0032389-enhances-proliferation-and-migration-in-pdgf-bb-induced-human-aortic-vascular-smooth-muscle-cells
#27
JOURNAL ARTICLE
Haiyun Qian, Shengwei Ma, Qian Zhou, Chengang Lei
Circular RNA (circRNAs) has been confirmed to participate in atherosclerosis (AS) progression. However, the role and mechanism of hsa_circ_0032389 in AS process still need to be further revealed. This study evaluates the role and mechanism of hsa_circ_0032389 in AS process. Platelet-derived growth factor-BB (PDGF-BB) was used to induce human aortic vascular smooth muscle cells (HA-VSMCs). The expression levels of hsa_circ_0032389, microRNA (miR)-513a-5p, and fibroblast growth factor receptor substrate 2 (FRS2) were examined by quantitative real-time PCR...
February 20, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38374991/expression-of-mirna-29c-in-the-carotid-plaque-and-its-association-with-diabetic-mellitus
#28
JOURNAL ARTICLE
Hua Wang, Peipei Mai, Fang He, Yanfang Zhang
BACKGROUND: Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments. METHODS: In our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38370227/integrin-%C3%AE-9%C3%AE-1-deficiency-does-not-impact-the-development-of-atherosclerosis-in-mice
#29
JOURNAL ARTICLE
In-Hyuk Jung, Nathan O Stitziel
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes cardiovascular disease in humans and mice. However, the receptor mediating the effect of SVEP1 on the development of disease remains unclear. We previously demonstrated that depleting either vascular smooth muscle cell (VSMC)- or myeloid cell-derived integrin α9β1, the first receptor that was identified to interact with SVEP1, did not phenocopy the disease-abrogating effect of depleting SVEP1...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38362707/cathepsin-g-promotes-arteriovenous-fistula-maturation-by-positively-regulating-the-mmp2-mmp9-pathway
#30
JOURNAL ARTICLE
Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang
BACKGROUND: Arteriovenous fistula (AVF) is currently the preferred vascular access for hemodialysis patients. However, the low maturation rate of AVF severely affects its use in patients. A more comprehensive understanding and study of the mechanisms of AVF maturation is urgently needed. METHODS AND RESULTS: In this study, we downloaded the publicly available datasets (GSE119296 and GSE220796) from the Gene Expression Omnibus (GEO) and merged them for subsequent analysis...
December 2024: Renal Failure
https://read.qxmd.com/read/38353392/medium-dose-formoterol-attenuated-abdominal-aortic-aneurysm-induced-by-epo-via-%C3%AE-2ar-camp-sirt1-pathway
#31
JOURNAL ARTICLE
Jianlin Zhang, Yu Cao, Ruiqing Ren, Wenhai Sui, Yun Zhang, Meng Zhang, Cheng Zhang
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease but effective drugs for treatment of AAA are still lacking. Recently, erythropoietin (EPO) is reported to induce AAA formation in apolipoprotein-E knock out (ApoE-/- ) mice but an effective antagonist is unknown. In this study, formoterol, a β2 adrenergic receptor (β2AR) agonist, is found to be a promising agent for inhibiting AAA. To test this hypothesis, ApoE-/- mice are treated with vehicle, EPO, and EPO plus low-, medium-, and high-dose formoterol, respectively...
February 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38345905/arterial-stiffness-from-basic-primers-to-integrative-physiology
#32
REVIEW
Véronique Regnault, Patrick Lacolley, Stéphane Laurent
The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness...
February 12, 2024: Annual Review of Physiology
https://read.qxmd.com/read/38344172/novel-in-vitro-evidence-on-the-beneficial-effect-of-quercetin-treatment-in-vascular-calcification
#33
JOURNAL ARTICLE
E Ceccherini, I Gisone, E Persiani, C Ippolito, A Falleni, A Cecchettini, F Vozzi
Vascular calcification is a pathological chronic condition characterized by calcium crystal deposition in the vessel wall and is a recurring event in atherosclerosis, chronic kidney disease, and diabetes. The lack of effective therapeutic treatments opened the research to natural products, which have shown promising potential in inhibiting the pathological process in different experimental models. This study investigated the anti-calcifying effects of Quercetin and Berberine extracts on vascular smooth muscle cells (VSMCs) treated with an inorganic phosphate solution for 7 days...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38342025/mtmr7-suppresses-the-phenotypic-switching-of-vascular-smooth-muscle-cell-and-vascular-intimal-hyperplasia-after-injury-via-regulating-p62-mtorc1-mediated-glucose-metabolism
#34
JOURNAL ARTICLE
Xiongshan Sun, Yao Yang, Weiwei Zhao, Mingliang Wang, Yingmei Chen, Jia Wang, Dachun Yang, Yongjian Yang
BACKGROUND AND AIMS: Myotubularin-related protein 7 (MTMR7) suppresses proliferation in various cell types and is associated with cardiovascular and cerebrovascular diseases. However, whether MTMR7 regulates vascular smooth muscle cell (VSMC) and vascular intimal hyperplasia remains unclear. We explored the role of MTMR7 in phenotypic switching of VSMC and vascular intimal hyperplasia after injury. METHODS AND RESULTS: MTMR7 expression was significantly downregulated in injured arteries...
February 1, 2024: Atherosclerosis
https://read.qxmd.com/read/38341835/adora3-a-key-player-in-the-pathogenesis-of-intracranial-aneurysms-and-a-potential-diagnostic-biomarker
#35
JOURNAL ARTICLE
Rui-Ting Hu, Hao-Wei Deng, Wen-Bin Teng, Shao-Dan Zhou, Zi-Ming Ye, Zi-Mei Dong, Chao Qin
BACKGROUND: The effects of genes on the development of intracranial aneurysms (IAs) remain to be elucidated, and reliable blood biomarkers for diagnosing IAs are yet to be established. This study aimed to identify genes associated with IAs pathogenesis and explore their diagnostic value by analyzing IAs datasets, conducting vascular smooth muscle cells (VSMC) experiments, and performing blood detection. METHODS: IAs datasets were collected and the differentially expressed genes were analyzed...
February 11, 2024: Molecular Diagnosis & Therapy
https://read.qxmd.com/read/38334967/calcium-signaling-in-endothelial-and-vascular-smooth-muscle-cells-sex-differences-and-the-influence-of-estrogens-and-androgens
#36
REVIEW
Daniel Asunción-Alvarez, Javier Palacios, Roberto O Ybañez-Julca, Cristhian N Rodriguez-Silva, Chukwuemeka Nwokocha, Fredi Cifuentes, David J Greensmith
Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMC) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a large body of evidence shows that sex hormone imbalance leads to dysregulation of Ca2+ signaling and this is a key factor in the pathogenesis of cardiovascular diseases. In this review, the effects of estrogens and androgens on vascular calcium-handling proteins are discussed, with emphasis on the associated genomic or non-genomic molecular mechanisms...
February 9, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38334628/high-glucose-levels-promote-switch-to-synthetic-vascular-smooth-muscle-cells-via-lactate-gpr81
#37
JOURNAL ARTICLE
Jing Yang, Glenn R Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang
Hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling from cardiomyocytes, immune cells, and vascular cells, which release fibroblast-activating mediators. However, their influences on vascular smooth muscle cells (vSMCs) have not been well examined. This study aimed to investigate whether contractile vascular vSMCs could develop a more synthetic phenotype in response to hyperglycemia...
January 26, 2024: Cells
https://read.qxmd.com/read/38333200/angiotensin-ii-induces-endothelial-dysfunction-and-vascular-remodeling-by-downregulating-trpv4-channels
#38
JOURNAL ARTICLE
Narendra Babu Kondapalli, Venkatesh Katari, Kesha Dalal, Sailaja Paruchuri, Charles K Thodeti
Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation of endothelial function is not well known. We and others have previously shown that mechanically activated ion channel, Transient Receptor Potential Vanilloid 4 (TRPV4) mediates flow- and/or receptor-dependent vasodilation via nitric oxide (NO) production in endothelial cells. Ang II was demonstrated to crosstalk with TRPV4 via angiotensin 1 receptor (AT1R) and β-arrestin signaling in epithelial and immortalized cells, however, the role of this crosstalk in endothelial cell function is not fully explored...
December 2023: J Mol Cell Cardiol Plus
https://read.qxmd.com/read/38331337/terazosin-attenuates-abdominal-aortic-aneurysm-formation-by-downregulating-peg3-expression-to-inhibit-vascular-smooth-muscle-cell-apoptosis-and-senescence
#39
JOURNAL ARTICLE
Xiuxian Wei, Yi Li, Tao Jiang, Pengcheng Luo, Yue Dai, Qian Wang, Mulin Xu, Jinhua Yan, Yongjun Li, Jingwen Gao, Lei Liu, Cuntai Zhang, Yu Liu
Abdominal aortic aneurysm (AAA), a vascular degenerative disease, is a potentially life-threatening condition characterised by the loss of vascular smooth muscle cells (VSMCs), degradation of extracellular matrix (ECM), inflammation, and oxidative stress. Despite the severity of AAA, effective drugs for treatment are scarce. At low doses, terazosin (TZ) exerts antiapoptotic and anti-inflammatory effects in several diseases, but its potential to protect against AAA remains unexplored. Herein, we investigated the effects of TZ in two AAA animal models: Angiotensin II (Ang II) infusion in Apoe-/- mice and calcium chloride application in C57BL/6J mice...
February 6, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38326659/doxorubicin-alters-g-protein-coupled-receptor-mediated-vasocontraction-in-rat-coronary-arteries
#40
JOURNAL ARTICLE
Caroline Lozahic, Helen Maddock, Mark Wheatley, Hardip Sandhu
Doxorubicin (Doxo)-associated cardio-and vasotoxicity has been recognised as a serious complication of cancer chemotherapy. The purpose of this novel paper was to determine the effect of Doxo on G-protein coupled receptor (GPCR)-mediated vasocontraction located on vascular smooth muscle cells. Rat left anterior descending artery segments were incubated for 24 h with 0.5 µM Doxo. The vasocontractile responses by activation of endothelin receptor type A (ETA ) and type B (ETB ), serotonin receptor 1B (5-HT1B ) and thromboxane A2 prostanoid receptor (TP) were investigated by a sensitive myography using specific agonists, while the specificity of the GPCR agonists was verified by applying selective antagonists (i...
February 8, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
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