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https://www.readbyqxmd.com/read/28212891/sulforaphane-inhibits-platelet-derived-growth-factor-induced-vascular-smooth-muscle-cell-proliferation-by-targeting-mtor-p70s6kinase-signaling-independent-of-nrf2-activation
#1
Noha M Shawky, Lakshman Segar
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2, a transcription factor) and/or inhibition of mammalian target of rapamycin (mTOR) are implicated in the suppression of vascular smooth muscle cell (VSMC) proliferation. The present study has examined the likely regulatory effects of sulforaphane (SFN, an antioxidant) on Nrf2 activation and platelet-derived growth factor (PDGF)-induced mTOR signaling in VSMCs. Using human aortic VSMCs, nuclear extraction and siRNA-mediated downregulation studies were performed to determine the role of Nrf2 on SFN regulation of PDGF-induced proliferative signaling...
February 14, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28207187/a-robust-method-to-generate-mechanically-anisotropic-vascular-smooth-muscle-cell-sheets-for-vascular-tissue-engineering
#2
Daniel E Backman, Bauer L LeSavage, Shivem B Shah, Joyce Y Wong
In arterial tissue engineering, mimicking native structure and mechanical properties is essential because compliance mismatch can lead to graft failure and further disease. With bottom-up tissue engineering approaches, designing tissue components with proper microscale mechanical properties is crucial to achieve the necessary macroscale properties in the final implant. This study develops a thermoresponsive cell culture platform for growing aligned vascular smooth muscle cell (VSMC) sheets by photografting N-isopropylacrylamide (NIPAAm) onto micropatterned poly(dimethysiloxane) (PDMS)...
February 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28205266/role-of-parnaparin-in-atherosclerosis
#3
Francesca Bonomini, Samanta Taurone, Pierpaolo Parnigotto, Loris Zamai, Luigi F Rodella, Marco Artico, Rita Rezzani
Atherosclerosis is characterized by a proliferation of vascular smooth muscle cells (VSMCs) and their migration to the intima, which induces thickening of the intima itself, but the mechanism remains poorly understood. Low molecular weight heparin (LMWH) inhibits the proliferation of VSMCs. Previous studies have shown that a LMWH, parnaparin (PNP), acts on the processes of atherogenesis and atheroprogression in experimental animal models. The aim of this study was to investigate the involvement of oxidative stress, inflammation and VSMCs in the regulation of vascular wall homeostasis...
February 16, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28203685/sgk1-up-regulates-orai1-expression-and-vsmc-migration-during-neointima-formation-after-arterial-injury
#4
Britta Walker-Allgaier, Malte Schaub, Ioana Alesutan, Jakob Voelkl, Sascha Geue, Patrick Münzer, José M Rodríguez, Dietmar Kuhl, Florian Lang, Meinrad Gawaz, Oliver Borst
No abstract text is available yet for this article.
February 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28193524/synthetic-peptide-ala-arg-glu-gly-glu-met-abolishes-pro-proliferative-and-anti-apoptotic-effects-of-high-glucose-in-vascular-smooth-muscle-cells
#5
Xiaozhou Cao, Yi Lyu, Junyu Ning, Xiaozhi Tang, Xinchun Shen
Apoptosis plays a critical role in normal vascular development and atherosclerosis. However, high glucose has been reported to generate a certain level of ROS that can inhibit vascular smooth muscle cell (VSMC) apoptosis, with the underlying mechanism remaining unclear. In this study, a synthetic peptide AREGEM (Ala-Arg-Glu-Gly-Glu-Met) exhibited antioxidative effects and was used to investigate its function in VSMCs during hyperglycaemia. MTT assay results demonstrated that AREGEM significantly attenuated high glucose-induced VSMCs proliferation...
February 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28191820/vascular-smooth-muscle-cell-glycocalyx-mediates-shear-stress-induced-contractile-responses-via-a-rho-kinase-rock-myosin-light-chain-phosphatase-mlcp-pathway
#6
Hongyan Kang, Jiajia Liu, Anqiang Sun, Xiao Liu, Yubo Fan, Xiaoyan Deng
The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal pathway of the glycocalyx mechanotransduction in shear stress regulated SMC contraction. Human umbilical vein SMCs (HUVSMCs) deprived of serum for 3-4 days were exposed to a step increase (0 to 20 dyn/cm(2)) in shear stress in a parallel plate flow chamber, and reduction in the cell area was quantified as contraction...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28189040/an-anti-%C3%AE-v%C3%AE-3-antibody-inhibits-coronary-artery-atherosclerosis-in-diabetic-pigs
#7
L A Maile, W H Busby, G Xi, K P Gollahan, W Flowers, N Gafbacik, S Gafbacik, K Stewart, E P Merricks, T C Nichols, D A Bellinger, D R Clemmons
BACKGROUND AND AIMS: Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin, a receptor that regulates VSMC proliferation and migration. This study determined whether an antibody that had previously been shown to block αVβ3 activation and to inhibit VSMC proliferation and migration in vitro, inhibited the development of atherosclerosis in diabetic pigs. METHODS: Twenty diabetic pigs were maintained on a high fat diet for 22 weeks...
January 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28186995/microrna-214-regulates-smooth-muscle-cell-differentiation-from-stem-cells-by-targeting-rna-binding-protein-qki
#8
Yutao Wu, Zhoubin Li, Mei Yang, Bing Dai, Feng Hu, Feng Yang, Jianhua Zhu, Ting Chen, Li Zhang
MicroRNA-214(miR-214) has been recently reported to regulate angiogenesis and embryonic stem cells (ESCs) differentiation. However, very little is known about its functional role in vascular smooth muscle cells (VSMCs) differentiation from ESCs. In the present study, we assessed the hypothesis that miR-214 and its target genes play an important role in VSMCs differentiation. Murine ESCs were seeded on collagen-coated flasks and cultured in differentiation medium for 2 to 8 days to allow VSMCs differentiation...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185804/7-cyclopentyl-5-4-phenoxyphenyl-7h-pyrrolo-2-3-d-pyrimidin-4-ylamine-inhibits-the-proliferation-and-migration-of-vascular-smooth-muscle-cells-by-suppressing-erk-and-akt-pathways
#9
Hyang-Hee Seo, Sang Woo Kim, Chang Youn Lee, Kyu Hee Lim, Jiyun Lee, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang
Excessive vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury significantly contributes to the development of occlusive vascular disease. Therefore, inhibiting the proliferation and migration of VSMCs is a validated therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. In the present study, we screened chemical compounds for their anti-proliferative effects on VSMCs using multiple approaches, such as MTT assays, wound healing assays, and trans-well migration assays...
February 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28178628/25-hydroxyvitamin-d-1-%C3%AE-hydroxylase-in-apoliporotein-e-knockout-mice-the-role-of-protecting-vascular-smooth-muscle-cell-from-calcification
#10
Wei Xiang, Wang Liao, Zhuwen Yi, Xiaojie He, Yan Ding
Previous publications widely reported that 25-hydroxyvitamin D-1-α-hydroxylase (CYP27B1) regulated the metabolism of 25-hydroxyvitamin D3, which has a close association between altered activity of vitamin D and vascular calcification has been reported in various human diseases, including chronic kidney disease, osteoporosis and atherosclerosis. Vascular calcification is a clinically significant component of atherosclerosis and may be promoted by ROS associated inflammatory. In this study, we evaluated the effect of 25-hydroxyvitamin D-1-α-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28171827/vascular-inflammation-and-media-calcification-are-already-present-in-early-stages-of-chronic-kidney-disease
#11
Kerstin Benz, Ildiko Varga, Daniel Neureiter, Valentina Campean, Christoph Daniel, Christian Heim, Albrecht Reimann, Michael Weyand, Karl F Hilgers, Kerstin Amann
BACKGROUND: While patients with chronic kidney disease (CKD) have a high prevalence of classical coronary risk factors, there is increasing evidence that atherosclerosis is different in renal compared to nonrenal patients. Therefore, the present study compares changes in different vessels obtained at cardiac surgery between patients with early and advanced CKD and nonrenal control patients. METHODS AND RESULTS: Fifty patients undergoing cardiac bypass surgery were divided into three groups: (i) 24 control patients with creatinine <1...
January 23, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28167124/p38-mapk-signaling-pathway-mediates-angiotensin%C3%A2-induced-mir143-145-gene-cluster-down-regulation-during-aortic-dissection-formation
#12
Bowen Li, Zhiwei Wang, Zhipeng Hu, Min Zhang, Zongli Ren, Zhen Zhou, Jizhen Huang, Xiaoping Hu
OBJECTIVES: We endeavored to prove that angiotensinⅡ (Ang Ⅱ) regulates both the expression of miR143/145 and differentiation of vascular smooth muscle cells (VSMCs) during the formation of aortic dissection. We also studied the contribution the p38 MAPK signaling pathway has towards this process. METHODS: Ascending aortic tissues were harvested from the patients with aortic dissection (AD) and organ donors.Tissues were immunostained with labeled antibodies targeting p38 MAPK,phospho-p38 MAPK,alpha-smooth muscle actin (α-SMA), and osteopontin (OPN)...
February 3, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28161059/dnk-derived-ifn-%C3%AE-mediates-vsmc-migration-and-apoptosis-via-the-induction-of-lncrna-meg3-a-role-in-uterovascular-transformation
#13
Weifang Liu, Xiaoxia Liu, Minglian Luo, Xiaoping Liu, Qingqing Luo, Hui Tao, Di Wu, Sisi Lu, Jing Jin, Yin Zhao, Li Zou
INTRODUCTION: Appropriate spiral artery remodeling is critical for successful fetal development and pregnancy outcomes. The vascular smooth muscle cell (VSMC) loss and separation, involving cell apoptosis and migration, plays an important role in this process. Decidual natural killer cells (dNK)-derived interferon gamma (IFN-γ), a key regulator of uterine arterial remodeling, can facilitate separation of VSMC layers, however, the specific mechanisms of it action are unknown. Long non-coding RNA MEG3 functions as tumor suppressor by regulating apoptosis and migration...
February 2017: Placenta
https://www.readbyqxmd.com/read/28155614/cartilage-oligomeric-matrix-protein-matricellular-and-matricrine-signaling-in-cardiovascular-homeostasis-and-disease
#14
Yi Fu, Wei Kong
Cardiovascular (CV) diseases remain a leading cause of morbidity and mortality in the world. Increasing the understanding of the pathogenesis of various CV diseases may provide novel therapeutic targets to improve their prevention and treatment. Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5 (TSP-5), is a matricellular protein that is abundantly expressed in both cartilage and the CV system. Our group and others have identified COMP as playing critical roles in maintaining CV homeostasis...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28150521/drug-repurposing-and-therapeutic-anti-microrna-predictions-for-inhibition-of-oxidized-low-density-lipoprotein-induced-vascular-smooth-muscle-cell-associated-diseases
#15
Shun-Tsung Chen, Chien-Hung Huang, Victor C Kok, Chi-Ying F Huang, Jin-Shuei Ciou, Jeffrey J P Tsai, Nilubon Kurubanjerdjit, Ka-Lok Ng
Drug repurposing is a new method for disease treatments, which accelerates the identification of new uses for existing drugs with minimal side effects for patients. MicroRNA-based therapeutics are a class of drugs that have been used in gene therapy following the FDA's approval of the first anti-sense therapy. This study examines the effects of oxLDL on vascular smooth muscle cells (VSMCs) and identifies potential drugs and antimiRs for treating VSMC-associated diseases. The Connectivity Map (cMap) database is utilized to identify potential new uses of existing drugs...
December 22, 2016: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28143713/intercellular-transfer-of-mir-126-3p-by-endothelial-microparticles-reduces-vascular-smooth-muscle-cell-proliferation-and-limits-neointima-formation-by-inhibiting-lrp6
#16
Felix Jansen, Tobias Stumpf, Sebastian Proebsting, Bernardo S Franklin, Daniela Wenzel, Philipp Pfeifer, Anna Flender, Theresa Schmitz, Xiaoyan Yang, Bernd K Fleischmann, Georg Nickenig, Nikos Werner
BACKGROUND: Vascular smooth muscle cell (VSMC) proliferation is of importance in the pathogenesis of vascular diseases such as restenosis or atherosclerosis. Endothelial microparticles (EMPs) regulate function and phenotype of target endothelial cells (ECs), but their influence on VSMC biology is unknown. We aim to investigate the role of EMPs in the regulation of vascular smooth muscle cell (VSMC) proliferation and vascular remodeling. METHODS AND RESULTS: Systemic treatment of mice with EMPs after vascular injury reduced neointima formation in vivo...
January 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28135581/smooth-muscle-cell-targeted-rna-aptamer-inhibits-neointimal-formation
#17
William H Thiel, Carla L Esposito, David D Dickey, Justin P Dassie, Matthew E Long, Joshua Adam, Jennifer Streeter, Brandon Schickling, Maysam Takapoo, Katie S Flenker, Julia Klesney-Tait, Vittorio de Franciscis, Francis J Miller, Paloma H Giangrande
Inhibition of vascular smooth muscle cell (VSMC) proliferation by drug eluting stents has markedly reduced intimal hyperplasia and subsequent in-stent restenosis. However, the effects of antiproliferative drugs on endothelial cells (EC) contribute to delayed re-endothelialization and late stent thrombosis. Cell-targeted therapies to inhibit VSMC remodeling while maintaining EC health are necessary to allow vascular healing while preventing restenosis. We describe an RNA aptamer (Apt 14) that functions as a smart drug by preferentially targeting VSMCs as compared to ECs and other myocytes...
April 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28134400/the-influence-of-phosphate-calcium-and-magnesium-on-matrix-gla-protein-and-vascular-calcification-a-systematic-review
#18
E Houben, A Neradova, L J Schurgers, Marc Vervloet
Vitamin K-dependent matrix Gla protein (MGP) is a key inhibitor of vascular calcification (VC). MGP is synthesized by chondrocytes and vascular smooth muscle cells (VSMC) and the absence or inactivity of MGP results in excessive calcification of both growth plate and vasculature. Apart from its vitamin K dependency little is known about other factors that influence MGP metabolism. Phosphate, calcium and magnesium are involved in bone mineralization and play an important role in VC. In this review we provide a summary of the effect of phosphate, calcium, and magnesium on MGP metabolism...
November 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28131048/c1q-tnf-related-protein-1-prevents-neointimal-formation-after-arterial-injury
#19
Noriyoshi Kanemura, Rei Shibata, Koji Ohashi, Hayato Ogawa, Mizuho Hiramatsu-Ito, Takashi Enomoto, Daisuke Yuasa, Masanori Ito, Satoko Hayakawa, Naoya Otaka, Toyoaki Murohara, Noriyuki Ouchi
BACKGROUND AND AIMS: Obesity contributes to the progression of vascular disorders. C1q/TNF-related protein (CTRP) 1 is a circulating adipokine, which is upregulated in obese complications including coronary artery disease. Here, we investigated the role of CTRP1 in regulation of vascular remodeling after mechanical injury and evaluated its potential mechanism. METHODS: Mice were subjected to wire-induced injury of left femoral arteries. An adenoviral vector encoding CTRP1 (Ad-CTRP1) or β-galactosidase as a control was injected into the jugular vein of mice 3 days prior to surgery...
January 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28126825/endosialin-promotes-atherosclerosis-through-phenotypic-remodeling-of-vascular-smooth-muscle-cells
#20
Zulfiyya Hasanov, Tina Ruckdeschel, Courtney König, Carolin Mogler, Stephanie S Kapel, Claudia Korn, Carleen Spegg, Viktoria Eichwald, Matthias Wieland, Sila Appak, Hellmut G Augustin
OBJECTIVE: Vascular smooth muscle cells (VSMC) play a key role in the pathogenesis of atherosclerosis, the globally leading cause of death. The transmembrane orphan receptor endosialin (CD248) has been characterized as an activation marker of cells of the mesenchymal lineage including tumor-associated pericytes, stromal myofibroblasts, and activated VSMC. We, therefore, hypothesized that VSMC-expressed endosialin may display functional involvement in the pathogenesis of atherosclerosis...
January 26, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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