keyword
https://read.qxmd.com/read/38496458/cooperative-involvement-of-zipper-interacting-protein-kinase-zipk-and-the-dual-specificity-cell-division-cycle-14a-phosphatase-cdc14a-in-vascular-smooth-muscle-cell-migration
#1
Abdulhameed Al-Ghabkari, David A Carlson, Timothy A J Haystead, Justin A MacDonald
Zipper-interacting protein kinase (ZIPK) is a Ser/Thr protein kinase with regulatory involvement in vascular smooth muscle cell (VSMC) actin polymerization and focal adhesion assembly dynamics. ZIPK silencing can induce cytoskeletal remodeling with disassembly of actin stress fiber networks and coincident loss of focal adhesion kinase (FAK)-pY397 phosphorylation. The link between ZIPK inhibition and FAK phosphorylation is unknown, and critical interactor(s) and regulator(s) are not yet defined. In this study, we further analyzed the ZIPK-FAK relationship in VSMCs...
March 9, 2024: bioRxiv
https://read.qxmd.com/read/38493694/costunolide-mitigates-inflammation-and-promotes-extracellualr-matrix-integrity-of-thoracic-aortic-dissection-by-inhibiting-nf-%C3%AE%C2%BAb-signaling
#2
REVIEW
Tonglei Han, Hanfei Tang, Changpo Lin, Dong Yan, Zhenyu Zhou, Yimin Yang, Liang Cai, Jiaqi Zhu, Bin Gao, Yi Si, Weiguo Fu, Zongguang Tai, Xiao Tang, Daqiao Guo
BACKGROUND: Thoracic aortic dissection (TAD) is one of the most fatal cardiovascular diseases. One of its important pathological characteristics is the local inflammatory response. Many studies have found that Macrophage polarization plays an extremely critical role in the inflammatory progression and tissue remodeling of TAD. Costunolide (CTD) has an improving effect on oxidative stress and inflammation in the body. However, whether it can promote the integrity of extracellular matrix in Aortic dissection and its mechanism are still unclear...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38488158/mir-200a-3p-inhibits-the-pdgf-bb-induced-proliferation-of-vsmcs-by-affecting-their-phenotype-associated-proteins
#3
JOURNAL ARTICLE
Rui-Yuan Zeng, Hong-Yi Jin, Yong-Bo Peng, Wen-Jun Wang, Yuan-Ping Cao, Han-Zhi Peng, Zhi-Cong Qiu, Song-Qing Lai, Li Wan
Accumulating evidence shows that the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) can significantly affect the long-term prognosis of coronary artery bypass grafting. This study aimed to explore the factors affecting the proliferation, migration, and phenotypic transformation of VSMCs. First, we stimulated VSMCs with different platelet-derived growth factor-BB (PDGF-BB) concentrations, analyzed the expression of phenotype-associated proteins by Western blotting, and examined cell proliferation by scratch wound healing and the 5-ethynyl-2-deoxyuridine (EdU) assay...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38476905/enhancer-of-zeste-homolog-2-facilitates-phenotypic-transition-of-vascular-smooth-muscle-cells-leading-to-aortic-aneurysm-dissection
#4
JOURNAL ARTICLE
Shishan Xue, Shuai Leng, Fengquan Zhang, Zhiqiao Dang, Guohai Su, Wenqian Yu
Thoracic aortic aneurysms (TAAs) are a major cause of death owing to weaker blood vessel walls and higher rupture rates in affected individuals. Vascular smooth muscle cells (VSMCs) are the predominant cell type within the aortic wall and their dysregulation may contribute to TAA progression. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, is involved in several pathological processes; however, the biological functions and mechanisms underlying VSMC phenotype transition and vascular intimal hyperplasia remain unclear...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38473817/inorganic-phosphate-induced-extracellular-vesicles-from-vascular-smooth-muscle-cells-contain-elevated-levels-of-hyaluronic-acid-which-enhance-their-interaction-with-very-small-superparamagnetic-iron-oxide-particles
#5
JOURNAL ARTICLE
Christian Freise, Karina Biskup, Véronique Blanchard, Jörg Schnorr, Matthias Taupitz
Patients with chronic kidney disease (CKD) have a high prevalence of hyperphosphatemia, where uremic toxins like inorganic phosphate (Pi) induce a cardiovascular remodeling. Related disorders like atherosclerosis bear the risk of increased morbidity and mortality. We previously found that Pi stimulates the synthesis and sulfation of the negatively charged glycosaminoglycans (GAGs) heparan sulfate and chondroitin sulfate in vascular smooth muscle cells (VSMC). Similar GAG alterations were detected in VSMC-derived exosome-like extracellular vesicles (EV)...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473793/a-comprehensive-retrospective-study-on-the-mechanisms-of-cyclic-mechanical-stretch-induced-vascular-smooth-muscle-cell-death-underlying-aortic-dissection-and-potential-therapeutics-for-preventing-acute-aortic-aneurysm-and-associated-ruptures
#6
REVIEW
Jing Zhao, Masanori Yoshizumi
Acute aortic dissection (AAD) and associated ruptures are the leading causes of death in cardiovascular diseases (CVDs). Hypertension is a prime risk factor for AAD. However, the molecular mechanisms underlying AAD remain poorly understood. We previously reported that cyclic mechanical stretch (CMS) leads to the death of rat aortic smooth muscle cells (RASMCs). This review focuses on the mechanisms of CMS-induced vascular smooth muscle cell (VSMC) death. Moreover, we have also discussed the potential therapeutics for preventing AAD and aneurysm ruptures...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38464026/thymidine-phosphorylase-promotes-the-formation-of-abdominal-aortic-aneurysm-in-mice-fed-a-western-diet
#7
Liang Hong, Hong Yue, Dunpeng Cai, Autumn DeHart, Gretel Toloza-Alvarez, Lili Du, Xianwu Zhou, Xiaoping Fan, Huanlei Huang, Shiyou Chen, Shaik O Rahaman, Jian Zhuang, Wei Li
AIMS: The precise molecular drivers of abdominal aortic aneurysm (AAA) remain unclear. Thymidine phosphorylase (TYMP) contributes to increased platelet activation, thrombosis, and inflammation, all of which are key factors in AAA development. Additionally, TYMP suppresses the proliferation of vascular smooth muscle cells (VSMCs), which are central to the development and progression of AAA. We hypothesize that TYMP plays a key role in AAA development. METHODS AND RESULTS: We conducted a histological study using human AAA samples and normal abdominal aortas, revealing heightened levels of TYMP in human AAA vessel walls...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38451018/ercc1-dna-repair-deficiency-results-in-vascular-aging-characterized-by-vsmc-phenotype-switching-ecm-remodeling-and-an-increased-stress-response
#8
JOURNAL ARTICLE
Janette van der Linden, Sanne J M Stefens, José María Heredia-Genestar, Yanto Ridwan, Renata M C Brandt, Nicole van Vliet, Isa de Beer, Bibi S van Thiel, Herman Steen, Caroline Cheng, Anton J M Roks, A H Jan Danser, Jeroen Essers, Ingrid van der Pluijm
Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the aging process, and mice with a DNA repair defect caused by Ercc1 deficiency display hypertension, vascular stiffening, and loss of vasomotor control. To determine the underlying cause, we compared important hallmarks of vascular aging in aortas of both Ercc1Δ/- and age-matched wildtype mice...
March 7, 2024: Aging Cell
https://read.qxmd.com/read/38434568/effect-of-tissue-factor-pathway-inhibitor-on-the-pyroptosis-of-vascular-smooth-muscle-cells-induced-by-angiotensin-ii
#9
JOURNAL ARTICLE
Yue Dai, Rui Xu, Kelaier Yang, Tingting Jiang, Yongkang Wei, Yue Liu, Wenjia Chen, Yu Fu, Yong Zhao
BACKGROUND: In recent years, a mass of studies have shown that pyroptosis plays an important role in the proliferation of vascular smooth muscle cells (VSMCs). We investigated whether angiotensin II (Ang II) induces the pyroptosis of rat aortic VSMCs and the role of NOD-like receptor family pyrin domain containing 3 (NLRP3) in this process. Additionally, we explored the effect and related mechanism of recombinant tissue factor pathway inhibitor (rTFPI) in Ang II-induced VSMC pyroptosis...
February 15, 2024: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/38434290/eif2%C3%AE-mediated-integrated-stress-response-links-multiple-intracellular-signaling-pathways-to-reprogram-vascular-smooth-muscle-cell-fate-in-carotid-artery-plaque
#10
JOURNAL ARTICLE
Jichang Luo, Xiao Zhang, Wenjing Li, Tao Wang, Shengyan Cui, Tianhua Li, Yilin Wang, Wenlong Xu, Yan Ma, Bin Yang, Yumin Luo, Ge Yang, Ran Xu, Liqun Jiao
BACKGROUND: Carotid arterial atherosclerotic stenosis is a well-recognized pathological basis of ischemic stroke; however, its underlying molecular mechanisms remain unknown. Vascular smooth muscle cells (VSMCs) play fundamental roles in the initiation and progression of atherosclerosis. Organelle dynamics have been reported to affect atherosclerosis development. However, the association between organelle dynamics and various cellular stresses in atherosclerotic progression remain ambiguous...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38426091/serum-secreted-phosphoprotein-1-level-is-associated-with-plaque-vulnerability-in-patients-with-coronary-artery-disease
#11
JOURNAL ARTICLE
Ke Huang, Shuai Chen, Lin-Jun Yu, Zhi-Ming Wu, Qiu-Jing Chen, Xiao-Qun Wang, Fei-Fei Li, Jing-Meng Liu, Yi-Xuan Wang, Lin-Shuang Mao, Wei-Feng Shen, Rui-Yan Zhang, Ying Shen, Lin Lu, Yang Dai, Feng-Hua Ding
BACKGROUND: Vulnerable plaque was associated with recurrent cardiovascular events. This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease. METHODS: To reveal the phenotype-associated cell type in the development of vulnerable plaque and to identify hub gene for pathological process, we combined single-cell RNA and bulk RNA sequencing datasets of human atherosclerotic plaques using Single-Cell Identification of Subpopulations with Bulk Sample Phenotype Correlation (Scissor) and Weighted gene co-expression network analysis (WGCNA)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38425784/igf1r-deficiency-in-vascular-smooth-muscle-cells-impairs-myogenic-autoregulation-and-cognition-in-mice
#12
JOURNAL ARTICLE
Lauren R Miller, Marisa A Bickel, Stefano Tarantini, Megan E Runion, Zoe Matacchiera, Michaela L Vance, Clara Hibbs, Hannah Vaden, Domonkos Nagykaldi, Teryn Martin, Elizabeth C Bullen, Jessica Pinckard, Tamas Kiss, Eric W Howard, Andriy Yabluchanskiy, Shannon M Conley
INTRODUCTION: Cerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 (IGF-1), a vasoprotective hormone, decrease during aging. Decreased circulating IGF-1 in animal models leads to the development of VCID-like symptoms, but the cellular mechanisms underlying IGF-1-deficiency associated pathologies in the aged cerebrovasculature remain poorly understood. Here, we test the hypothesis that vascular smooth muscle cells (VSMCs) play an integral part in mediating the vasoprotective effects of IGF-1...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38421345/primary-mouse-aortic-smooth-muscle-cells-exhibit-region-and-sex-dependent-biological-responses-in-vitro
#13
JOURNAL ARTICLE
Niyousha Karbasion, Yujun Xu, J Caleb Snider, Matthew R Bersi
Despite advancements in elucidating biological mechanisms of cardiovascular remodeling, cardiovascular disease (CVD) remains the leading cause of death worldwide. When stratified by sex, clear differences in CVD prevalence and mortality between males and females emerge. Regional differences in phenotype and biological response of cardiovascular cells are important for localizing the initiation and progression of CVD. Thus, to better understand region and sex differences in CVD presentation we have focused on characterizing in vitro behaviors of primary vascular smooth muscle cells (VSMCs) from the thoracic and abdominal aorta of male and female mice...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38420807/single-cell-transcriptome-analysis-identified-core-genes-and-transcription-factors-in-mesenchymal-cell-differentiation-during-liver-cirrhosis
#14
JOURNAL ARTICLE
Xue Dai, Hui-Lin Zheng, Ya-Xin Ma, Yun-Yan Wang, Mai-Qiu Wang, Hai-Ying Cai, Zhen-Hua Hu, Jian Wan, Lei Zhang
BACKGROUND: Mesenchymal cells, including hepatic stellate cells (HSCs), fibroblasts (FBs), myofibroblasts (MFBs), and vascular smooth muscle cells (VSMCs), are the main cells that affect liver fibrosis and play crucial roles in maintaining tissue homeostasis. The dynamic evolution of mesenchymal cells is very important but remains to be explored for researching the reversible mechanism of hepatic fibrosis and its evolution mechanism of hepatic fibrosis to cirrhosis. METHODS: Here, we analysed the transcriptomes of more than 50,000 human single cells from three cirrhotic and three healthy liver tissue samples and the mouse hepatic mesenchymal cells of two healthy and two fibrotic livers to reconstruct the evolutionary trajectory of hepatic mesenchymal cells from a healthy to a cirrhotic state, and a subsequent integrative analysis of bulk RNA sequencing (RNA-seq) data of HSCs from quiescent to active (using transforming growth factor β1 (TGF-β1) to stimulate LX-2) to inactive states...
February 6, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38409514/circhat1-regulates-the-proliferation-and-phenotype-switch-of-vascular-smooth-muscle-cells-in-lower-extremity-arteriosclerosis-obliterans-through-targeting-sfrs1
#15
JOURNAL ARTICLE
Xian-Ying Huang, Fang-Yong Fu, Kai Qian, Qiao-Li Feng, Sai Cao, Wei-Yu Wu, Yuan-Lin Luo, Wei-Jie Chen, Zhi Zhang, Shui-Chuan Huang
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significantly down-regulated cardiac specific circRNA-circHAT1 in LEASO. The expression of circHAT1 in LEASO clinical samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression of splicing factor arginine/serine-rich 1 (SFRS1), α-smooth muscle actin (α-SMA), Calponin (CNN1), cyclin D1 (CNND1) and smooth muscle myosin heavy chain 11 (SMHC) in vascular smooth muscle cells (VSMCs) was detected by Western blotting...
February 26, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38405620/salvianolic-acid-b-alleviates-high-glucose-induced-vascular-smooth-muscle-cell-inflammation-by-upregulating-the-mir-486a-5p-expression
#16
JOURNAL ARTICLE
Man-Li Zhang, Man-Na Zhang, Hui Chen, Xia Wang, Kun Zhao, Xuan Li, Xuan Song, Fei Tong
The macrovascular complications of diabetes cause high mortality and disability in patients with type 2 diabetes mellitus (T2DM). The inflammatory response of vascular smooth muscle cell (VSMC) runs through its pathophysiological process. Salvianolic acid B (Sal B) exhibits beneficial effects on the cardiovascular system. However, its role and mechanism in diabetic vascular inflammatory response remain unclear. In this study, we found that Sal B reduced vascular inflammation in diabetic mice and high glucose- (HG-) induced VSMC inflammation...
2024: Mediators of Inflammation
https://read.qxmd.com/read/38402026/lysyl-oxidase-expression-in-smooth-muscle-cells-determines-the-level-of-intima-calcification-in-hypercholesterolemia-induced-atherosclerosis
#17
JOURNAL ARTICLE
Carme Ballester-Servera, Judith Alonso, Manel Taurón, Noemí Rotllán, Cristina Rodríguez, José Martínez-González
INTRODUCTION: Cardiovascular calcification is an important public health issue with an unmeet therapeutic need. We had previously shown that lysyl oxidase (LOX) activity critically influences vascular wall smooth muscle cells (VSMCs) and valvular interstitial cells (VICs) calcification by affecting extracellular matrix remodeling. We have delved into the participation of LOX in atherosclerosis and vascular calcification, as well as in the mineralization of the aortic valve. METHODS: Immunohistochemical and expression studies were carried out in human atherosclerotic lesions and experimental models, valves from patients with aortic stenosis, VICs, and in a genetically modified mouse model that overexpresses LOX in CMLV (TgLOXCMLV )...
February 23, 2024: Clínica e Investigación en Arteriosclerosis
https://read.qxmd.com/read/38401035/neutrophil-extracellular-traps-a-catalyst-for-atherosclerosis
#18
REVIEW
Yinyu Wang, Cuiping Wang, Jiayan Li
Neutrophil extracellular traps (NETs) are network-like structures released by activated neutrophils. They consist mainly of double-stranded DNA, histones, and neutrophil granule proteins. Continuous release of NETs in response to external stimuli leads to activation of surrounding platelets and monocytes/macrophages, resulting in damage to endothelial cells (EC) and vascular smooth muscle cells (VSMC). Some clinical trials have demonstrated the association between NETs and the severity and prognosis of atherosclerosis...
February 24, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38395882/runx1-vascular-smooth-muscle-cells-are-essential-for-hematopoietic-stem-and-progenitor-cell-development-in-vivo
#19
JOURNAL ARTICLE
Zaniah N Gonzalez Galofre, Alastair M Kilpatrick, Madalena Marques, Diana Sá da Bandeira, Telma Ventura, Mario Gomez Salazar, Léa Bouilleau, Yvan Marc, Ana B Barbosa, Fiona Rossi, Mariana Beltran, Harmen J G van de Werken, Wilfred F J van IJcken, Neil C Henderson, Stuart J Forbes, Mihaela Crisan
Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-like precursors were recently identified in the aorta-gonad-mesonephros (AGM) region; however, their role in the hematopoietic development in vivo remains unknown. Here, we identify a subpopulation of NG2+ Runx1+ perivascular cells that display a sclerotome-derived vSMC transcriptomic profile...
February 23, 2024: Nature Communications
https://read.qxmd.com/read/38394688/circcdyl-contributes-to-apoptosis-ferroptosis-and-oxidative-stress-of-ang-ii-induced-vascular-smooth-muscle-cells-in-thoracic-aortic-aneurysm
#20
JOURNAL ARTICLE
Changjiang Fu, Xiangrong Zuo, Jinghui An, Yanlong Zhang, Lixin Guo, Huashun Li
Circular RNAs (circRNAs) have important regulation in thoracic aortic aneurysm (TAA). The function and mechanism of circCDYL (circ_0008285) was explored in TAA here. Angiotensin II (Ang II) was used to construct a TAA model. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed for the detection of circCDYL, miR-1270, and a disintegrin and metalloproteinase 10 (ADAM10). Cell viability was examined via cell counting kit-8 (CCK-8) assay and proliferation was analyzed using Ethynyl-2'-deoxyuridine (EdU) assay...
February 23, 2024: Angiology
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