keyword
MENU ▼
Read by QxMD icon Read
search

Vsmc

keyword
https://www.readbyqxmd.com/read/29150938/regulation-of-calcification-in-human-aortic-smooth-muscle-cells-infected-with-high-glucose-treated-porphyromonas-gingivalis
#1
Te-Chuan Chen, Chien-Tsong Lin, Shao-Ju Chien, Shun-Fu Chang, Cheng-Nan Chen
Porphyromonas (P.) gingivalis infection leading to the periodontitis has been associated with the development of systemic diseases, including cardiovascular diseases and diabetes. However, the effect of a high concentration of glucose (HG) on the invasion efficiency of P. gingivalis and the consequent modulation of pathogenesis in vascular cells, especially in the vascular smooth muscle cells (VSMCs), remains unclear. Hence, the aim of this study was to investigate whether treating P. gingivalis with HG could change its invasion capability and result in VSMC calcification and the underlying mechanism...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149696/clearance-of-plasmin-pn-1-complexes-by-vascular-smooth-muscle-cells-in-human-aneurysm-of-the-ascending-aorta
#2
Kamel Boukais, Luciano F Borges, Laurence Venisse, Ziad Touat, Déborah François, Véronique Arocas, Guillaume Jondeau, Paul Declerck, Marie-Christine Bouton, Jean-Baptiste Michel
Plasminogen is a circulating zymogen which enters the arterial wall by radial, transmural hydraulic conductance, where it is converted to plasmin by tissue plasminogen activator t-PA on an activation platform involving S100A4 on the vascular smooth muscle cell (vSMC) membrane. Plasmin is involved in the progression of human thoracic aneurysm of the ascending aorta (TAA). vSMCs protect the TAA wall from plasmin-induced proteolytic injury by expressing high levels of antiproteases. Protease nexin-1 (PN-1) is a tissue antiprotease belonging to the serpin superfamily, expressed in the vascular wall, and is able to form a covalent complex with plasmin...
October 24, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29133788/regulation-of-angiotensin-ii-actions-by-enhancers-and-super-enhancers-in-vascular-smooth-muscle-cells
#3
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E Schones, Rama Natarajan
Angiotensin II (AngII) promotes hypertension and atherosclerosis by activating growth-promoting and pro-inflammatory gene expression in vascular smooth muscle cells (VSMCs). Enhancers and super-enhancers (SEs) play critical roles in driving disease-associated gene expression. However, enhancers/SEs mediating VSMC dysfunction remain uncharacterized. Here, we show that AngII alters vascular enhancer and SE repertoires in cultured VSMCs in vitro, ex vivo, and in AngII-infused mice aortas in vivo. AngII-induced enhancers/SEs are enriched in binding sites for signal-dependent transcription factors and dependent on key signaling kinases...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29131252/yap1-up-regulation-inhibits-apoptosis-of-aortic-dissection-vascular-smooth-muscle-cells
#4
T Liu, J Xu, J-L Guo, C-Y Lin, W-M Luo, Y Yuan, H Liu, J Zhang
OBJECTIVE: Elevated apoptosis of vascular smooth muscle cell (VSMC) is correlated with the occurrence of aortic dissection (AD). Yes-associated protein 1 (YAP1) is the major effector in Hippo-YAP signal pathway, which facilitates cell proliferation and suppressing apoptosis. Several studies have been performed regarding the relationship between YAP1 and AD pathogenesis. This study established the AD rat model to investigate possible roles of YAP1 in regulating VSMC apoptosis and AD pathogenesis...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29128361/involvement-of-mitochondrial-fission-in-calcium-sensing-receptor-mediated-vascular-smooth-muscle-cell-proliferation-during-hypertension
#5
Xin Zhang, Wenjia Chen, Jiawen Li, Shuhan Qi, Siting Hong, Ying Wang, Lei Gao, Zhiyu Shi, Yue Liu, Wenxiu Liu, Yinyu Chi, Chunnan Liu, Yu Fu, Xinhua Yin
Hyperproliferation of vascular smooth muscle cells (VSMC) is a major risk factor for cardiovascular diseases. Proper mitochondrial fission and fusion is involved with VSMC function. However, the role and mechanism of mitochondrial morphological changes in VSMC proliferation are not well understood. Here, we found that calcium sensing receptor (CaSR) was increased in the aortas from spontaneous hypertensive rats (SHRs) compared with age-matched Wistar Kyoto (WKY) rats. There was also an increase in mitochondrial fission and VSMC proliferation, which was attenuated by Calhex231...
November 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29127880/effects-of-flavonoids-on-microrna-145-regulation-through-klf4-and-myocardin-in-neointimal-formation-in-vitro-and-in-vivo
#6
Chiu-Mei Lin, Bao-Wei Wang, Chun-Ming Pan, Wei-Jen Fang, Su-Kiat Chua, Sheng-Wen Hou, Hang Chang, Kou-Gi Shyu
MicroRNA 145 (miR-145) is a critical modulator of vascular smooth muscle cell (VSMC) phenotyping and proliferation. Flavonoids have been studied extensively due to their diverse pharmacological properties, including anti-inflammatory effects. The aims of this study is designed to evaluate the atheroprotective effects on angiotensin II (Ang II)-induced miR-145 and Klf4/myocardin expression in vitro and in vivo of flavonoids, including (-)-epigallocatechin gallate (EGCG), chrysin, wogonin, silibinin, and ferulic acid...
September 14, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29115493/mir-92a-regulates-the-expression-levels-of-matrix-metalloproteinase-9-and-tissue-inhibitor-of-metalloproteinase-3-via-sirtuin-1-signaling-in-hydrogen-peroxide-induced-vascular-smooth-muscle-cells
#7
Peng Liu, Jianfang Su, Xixi Song, Shixiao Wang
Vascular smooth muscle cells (VSMCs) exhibit a notably increased rate of migration, which is one of the most common pathological changes in atherosclerosis. Investigations into the role of micro (mi)RNAs in the regulation of VSMC migration are beginning to emerge and additional miRNAs involved in VSMC migration modulation require identification. In the current study, VSMCs were primarily cultured from rat thoracic aortas, transfected with miR‑92a mimics and induced by hydrogen peroxide (H2O2) for 24 h. Total mRNA and protein were collected for quantitative polymerase chain reaction and western blot analysis...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115381/proliferation-of-vascular-smooth-muscle-cells-under-inflammation-is-regulated-by-nf-%C3%AE%C2%BAb-p65-microrna-17-rb-pathway-activation
#8
Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
Inflammation and excessive proliferation of vascular smooth muscle cells (VSMCs) have key roles in various vascular disorders, including restenosis, atherosclerosis and pulmonary artery hypertension. However, the underlying mechanism remains unclear. The present study investigated the role of nuclear factor-κB (NF-κB) and microRNA (miRNA) in the regulation of VSMC proliferation under inflammatory conditions. It was demonstrated that miR‑17 stimulated the proliferation of VSMCs, enhanced cell cycle G1/S transition, and increased levels of proliferating cell nuclear antigen and E2F1...
October 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29112156/effects-of-lonomia-obliqua-venom-on-vascular-smooth-muscle-cells-contribution-of-nadph-oxidase-derived-reactive-oxygen-species
#9
João Alfredo Moraes, Genilson Rodrigues, Vany Nascimento-Silva, Mariana Renovato-Martins, Markus Berger, Jorge Almeida Guimarães, Christina Barja-Fidalgo
Envenomation caused by human contact with the caterpillar Lonomia is characterized by deleterious effects on coagulation and patency of blood vessels. The cellular effects induced by Lonomia obliqua venom highlights its capacity to activate endothelial cells, leading to a proinflammatory phenotype. Having more knowledge about the mechanisms involved in envenomation may contribute to better treatment. We aimed to evaluate the effects of Lonomia obliqua caterpillar bristle extract (LOCBE) on vascular smooth muscle cells (VSMC)...
November 7, 2017: Toxins
https://www.readbyqxmd.com/read/29110368/kv-channels-and-vascular-smooth-muscle-cells-proliferation
#10
José R López-López, Pilar Cidad, M Teresa Pérez-García
Kv channels are present in virtually all vascular smooth muscle cells (VSMC) and strongly influence contractile responses. However, they are also instrumental in the proliferative, migratory and secretory functions of synthetic, dedifferentiated VSMCs cells upon phenotypic modulation (PM). In fact, Kv channels not only contribute to all these processes but they are also active players in the phenotypic switch itself. This review is focused on the role(s) of Kv channels in VSMC proliferation, which is one of the best characterized functions of dedifferentiated VSMCs...
November 7, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29107826/inhibition-of-vascular-smooth-muscle-cells-premature-senescence-with-rutin-attenuates-and-stabilizes-diabetic-atherosclerosis
#11
Yihui Li, Ranran Qin, Hongdan Yan, Feng Wang, Shanying Huang, Yun Zhang, Ming Zhong, Wei Zhang, Zhihao Wang
Atherosclerosis is an age-associated disease; however, diabetic atherosclerosis has higher severity beyond age range for accumulative premature senescent cells in diabetes. Recent findings suggest that rutin, a flavonoid, has potential benefits for diabetic individuals. This study was designed to evaluate the effects of rutin on premature senescence and atherosclerosis. Apolipoprotein E knockout mice exhibiting insulin resistance after 6 weeks of high-fat diet were administered with a low dose of streptozotocin (STZ) to induce diabetes...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29105817/loss-of-spry1-attenuates-vascular-smooth-muscle-proliferation-by-impairing-mitogen-mediated-changes-in-cell-cycle-regulatory-circuits
#12
Xuehui Yang, Yan Gong, Qing He, Jonathan D Licht, Lucy Liaw, Robert E Friesel
Signals from growth factors or mechanical stimuli converge to promote vascular smooth muscle cell (VSMC) migration and proliferation, key events in the pathogenesis of intimal hyperplasia upon vascular injury. Spry1, a regulator of receptor tyrosine kinases (RTK), plays a role in maintaining the contractile phenotype of VSMC. The aim of the current study was to determine the role of Spry1 in VSMC proliferation in vitro and injury induced neointimal hyperplasia in vivo. VSMC proliferation and neointima formation were evaluated in cultured human aortic SMC (hAoSMC) and ligation-induced injury of mouse carotid arteries from Spry1 gene targeted mice, and their corresponding wild type littermates...
November 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29104843/silencing-mir-16-expression-promotes-angiotensin-ii-stimulated-vascular-smooth-muscle-cell-growth
#13
Qingqing Gu, Guannan Zhao, Yinan Wang, Biao Xu, Junming Yue
miRNAs are a class of non-coding endogenous small RNAs that control gene expression at the posttranscriptional level and involved in cell proliferation, migration and differentiation. Dysregulation of miRNA expression is involved in a variety of human diseases including cardiovascular diseases. miRNAs have been shown to regulate vascular smooth muscle cell (VSMC) function and play vital roles in hypertension, restenosis and atherosclerosis. Here we reported that miR-16 as one of miRNAs in the miR-15 family was highly expressed in vascular smooth muscle cells (VSMCs) and involved in angiotensin II (Ang II) mediated VSMC signaling pathways...
March 2017: Cell & Developmental Biology
https://www.readbyqxmd.com/read/29104497/adenovirus-mediated-gene-transfer-of-microrna-21-sponge-inhibits-neointimal-hyperplasia-in-rat-vein-grafts
#14
Xiao-Wen Wang, Cheng Zhang, Kai-Chuen Lee, Xiang-Jun He, Zhi-Qian Lu, Chun Huang, Qing-Chen Wu
Background: Vein graft failure due to neointimal hyperplasia remains an important and unresolved complication of cardiovascular surgery. microRNA-21 (miR-21) plays a major role in regulating vascular smooth muscle cell (VSMC) proliferation and phenotype transformation. Thus, the purpose of this study was to determine whether adenovirus-mediated miR-21 sponge gene therapy was able to inhibit neointimal hyperplasia in rat vein grafts. Methods: Adenovirus-mediated miR-21 sponge was used to inhibit VSMC proliferation in vitro and neointimal formation in vivo...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29100378/sitagliptin-attenuates-high-glucose-induced-alterations-in-migration-proliferation-calcification-and-apoptosis-of-vascular-smooth-muscle-cells-through-erk1-2-signal-pathway
#15
Lili Shi, Ye Ji, Dandan Liu, Ying Liu, Ying Xu, Yang Cao, Xiaoyan Jiang, Changqing Xu
Background/Aims: This study investigated the effects of sitagliptin on migration, proliferation, calcification and apoptosis of vascular smooth muscle cells (VSMCs) under high glucose (HG) conditions. Methods: VSMCs were isolated from the thoracic aorta of Sprague Dawley rats. The cultured VSMCs were subjected to control medium, mannitol medium, HG medium (25 mM), pretreatment with 200 nM sitagliptin in control or HG medium, or the ERK1/2 inhibitor PD98059 in HG medium...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100354/mechanism-of-genistein-regulating-the-differentiation-of-vascular-smooth-muscle-cells-into-osteoblasts-via-the-opg-rankl-pathway
#16
Cheng Shen, Ye Yuan, Fuping Li, Yijie Hu, Yi Song, Shulin Zhao, Qianjin Zhong
Objective: The present study aimed to investigate the mechanism of genistein, a tyrosine kinase inhibitor, regulating the differentiation of vascular smooth muscle cells (VSMCs) into osteoblasts via the OPG/RANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor-κB Ligand) pathway. Methods: The mouse VSMCs were isolated, purified and cultured. We constructed the LV5-Tnfrsf11b overexpression lentiviral vector and LV3-OPG-309 interference lentiviral vector. The OPG overexpression was induced and the growth of VSMCs infected with the lentiviral vector was observed...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100273/mir-26a-contributes-to-the-pdgf-bb-induced-phenotypic-switch-of-vascular-smooth-muscle-cells-by-suppressing-smad1
#17
Xiaoyan Yang, Mei Dong, Hao Wen, Xiaoling Liu, Meng Zhang, Lianyue Ma, Cheng Zhang, Xiaorong Luan, Huixia Lu, Yun Zhang
The phenotypic switch of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of various vascular diseases, such as atherosclerosis and post-angioplasty restenosis. Small non-coding microRNAs (miRNAs) have emerged as critical modulators of VSMC function. In the present study, miR-26a was significantly increased in cultured VSMCs stimulated by platelet-derived growth factor-BB (PDGF-BB) and in arteries with neointimal lesion formation. Moreover, we demonstrated that miR-26a regulates the expression of VSMC differentiation marker genes such as α-smooth muscle actin (α-SMA), calponin and smooth muscle myosin heavy chain (SM-MHC) in PDGF-BB-treated VSMCs...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29091861/microrna-574-5p-promotes-cell-growth-of-vascular-smooth-muscle-cells-in-the-progression-of-coronary-artery-disease
#18
Zhongmeng Lai, Pengtao Lin, Xianfeng Weng, Jiansheng Su, Ye Chen, Ying He, Guohua Wu, Jiebo Wang, Ying Yu, Liangcheng Zhang
Coronary artery disease (CAD) is caused by atherosclerotic plaque development in the walls of coronary arteries. Aberrant proliferation of vascular smooth muscle cells (VSMCs) promotes atherosclerotic plaque formation, whereas VSMC apoptosis may promote CAD-related inflammation. microRNAs are potential diagnostic biomarkers in cardiovascular disease, especially CAD. Previous reports found that, among patients with CAD, microRNA-574-5p (miR-574-5p) expression was significantly increased and associated with disease severity...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29089350/unspliced-xbp1-confers-vsmc-homeostasis-and-prevents-aortic-aneurysm-formation-via-foxo4-interaction
#19
Guizhen Zhao, Yi Fu, Zeyu Cai, Fang Yu, Ze Gong, Rongbo Dai, Yanhua Hu, Lingfang Zeng, Qingbo Xu, Wei Kong
Rationale: Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile phenotype of VSMCs may confer vascular homeostasis and prevent aneurysmal disease. X-box binding protein 1, which exists in a transcriptionally inactive unspliced form (XBP1u) and a spliced active form (XBP1s), is a key component in response to endoplasmic reticular (ER) stress...
October 31, 2017: Circulation Research
https://www.readbyqxmd.com/read/29084284/a-novel-multicolor-flow-cytometry-application-for-quantitative-detection-of-receptors-on-vascular-smooth-muscle-cells
#20
Aneta Radziwon-Balicka, Matilda Degn, Sara E Johansson, Karin Warfvinge, Lars Edvinsson
There is a need to develop new techniques for quantitative measurement of receptors expression on particular vasculature cells types. Here, we describe and demonstrate a novel method to measure quantitatively and simultaneously the expression of endothelin B receptor (ETB) on vascular smooth muscle cells (VSMC). We isolated cells from male rat tissues such as: brain pial, brain intraparenchymal and retina vessels. To analyze solid tissues, a single-cell suspension was prepared by a combined mechanic and enzymatic process...
2017: PloS One
keyword
keyword
42800
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"