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https://www.readbyqxmd.com/read/29346401/cd1d-deficiency-inhibits-the-development-of-abdominal-aortic-aneurysms-in-ldl-receptor-deficient-mice
#1
Gijs H M van Puijvelde, Amanda C Foks, Rosemarie E van Bochove, Ilze Bot, Kim L L Habets, Saskia C de Jager, Mariëtte N D Ter Borg, Puck van Osch, Louis Boon, Mariska Vos, Vivian de Waard, Johan Kuiper
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (Ang II). We demonstrate that a deficiency in CD1d dependent NKT cells under hyperlipidemic conditions (LDLr-/-CD1d-/- mice) results in a strong decline in the severity of angiotensin II induced aneurysm formation when compared with LDLr-/- mice...
2018: PloS One
https://www.readbyqxmd.com/read/29344304/atherosclerosis-is-exacerbated-by-chitinase-3-like-1-in-amyloid-precursor-protein-transgenic-mice
#2
Yu Yeon Jung, Ki Cheon Kim, Mi Hee Park, Youngsik Seo, Heonyong Park, Min Hee Park, Jun Chang, Dae Youn Hwang, Sang Bae Han, Sanghyeon Kim, Dong Ju Son, Jin Tae Hong
Although the important role of amyloid precursor protein (APP) in vascular diseases associated with Alzheimer's disease (AD) has been demonstrated, the underlying molecular mechanisms and physiological consequences are unclear. We aimed to evaluate vascular inflammation and atherosclerosis in Swedish mutant of human APP transgenic (APPsw-Tg) and ApoE-/-/APPsw-Tg mice. We also aimed to explore the mechanisms underlying any changes observed in these mice compared with non-Tg controls. Methods: The transgenic and non-Tg mouse strains were subjected to partial ligation of the left carotid artery to induce atherosclerotic changes, which were measured using histological approaches, immunohistochemistry, quantitative polymerase chain reaction, and gene expression microarrays...
2018: Theranostics
https://www.readbyqxmd.com/read/29337033/gliclazide-a-katp-channel-blocker-inhibits-vascular-smooth-muscle-cell-proliferation-through-the-camkk%C3%AE-ampk-pathway
#3
Kyung Young Lee, Jae-Ryong Kim, Hyoung Chul Choi
Gliclazide, a sulfonylurea that is widely used to treat type II-diabetes, specifically blocks KATP channels and recombinant smooth muscle (SUR2B/Kir6.1) KATP channels with high potency. Furthermore, it exerts antioxidant properties and inhibits tumor cell proliferation. In this study, we investigated the inhibitory effect of gliclazide on vascular smooth muscle cell (VSMC) proliferation and tried to identify the underlying signaling pathway. We first investigated the effect of gliclazide-induced AMP-activated protein kinase (AMPK) activation on the proliferation of VSMCs...
January 11, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29332916/mir-135a-promotes-inflammatory-responses-of-vascular-smooth-muscle-cells-from-db-db-mice-via-downregulation-of-foxo1
#4
Xiaochun Lu, Dawei Yin, Bo Zhou, Tieling Li
It has been shown that microRNAs (miRNAs) greatly affect the functions of vascular smooth muscle cells (VSMC), but the effects of mRNAs under diabetic conditions remain unclear.Using a model of diabetic db/db mice, we studied the functions of microRNA-135a (miR-135a) during VSMC dysfunction.Compared to control WT mice, miR-135a expression in VSMC was significantly increased while the level of forkhead box O1 (FOXO1) protein decreased significantly. After transfecting miR-135a mimics into VSMC, the expression of FOXO1 was decreased, while cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1) expression levels were increased, thus promoting the interaction between monocytes and WT VSMC...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29326312/foxo3a-forkhead-transcription-factor-o-subfamily-member-3a-links-vascular-smooth-muscle-cell-apoptosis-matrix-breakdown-atherosclerosis-and-vascular-remodeling-through-a-novel-pathway-involving-mmp13-matrix-metalloproteinase-13
#5
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a (forkhead transcription factor O subfamily member 3a) is activated in human atherosclerosis and induces a range of proapoptotic and other transcriptional targets. We, therefore, determined the mechanisms and consequences of FOXO3a activation in atherosclerosis and arterial remodeling after injury...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29324316/microrna-145-alleviates-high-glucose-induced-proliferation-and-migration-of-vascular-smooth-muscle-cells-through-targeting-rock1
#6
Mantian Chen, Yi Zhang, Wei Li, Jieying Yang
The excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are important steps in atherosclerosis. The present study aimed to investigate whether the high glucose-induced changes of VSCMs are mediated by miR-145 and the potential molecular mechanism involved. We found that loss of miR-145 accompanied with increased proliferation and migration was observed in cultured human VSMCs exposed to high glucose. Exogenous overexpression of miR-145 effectively suppressed the high glucose-induced excessive proliferation and migration of VSMCs...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29323138/whole-mount-adult-ear-skin-imaging-reveals-defective-neuro-vascular-branching-morphogenesis-in-obese-and-type-2-diabetic-mouse-models
#7
Tomoko Yamazaki, Wenling Li, Ling Yang, Ping Li, Haiming Cao, Sei-Ichiro Motegi, Mark C Udey, Elise Bernhard, Takahisa Nakamura, Yoh-Suke Mukouyama
Obesity and type 2 diabetes are frequently associated with peripheral neuropathy. Though there are multiple methods for diagnosis and analysis of morphological changes of peripheral nerves and blood vessels, three-dimensional high-resolution imaging is necessary to appreciate the pathogenesis with an anatomically recognizable branching morphogenesis and patterning. Here we established a novel technique for whole-mount imaging of adult mouse ear skin to visualize branching morphogenesis and patterning of peripheral nerves and blood vessels...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310814/microarray-expression-profile-analysis-of-long-non-coding-rnas-in-thoracic-aortic-aneurysm
#8
Yang Li, Nan Yang
Thoracic aortic aneurysm (TAA) is a highly lethal vascular disease. Long non-coding RNAs (lncRNAs) are newly discovered as a regulator of protein genes and play critical roles in cardiovascular physio-pathological processes. However, there were a few studies looking at lncRNAs in TAA. In this study, we profiled differential expression of lncRNAs between TAA (TAA group, N = 6) and normal thoracic aorta (control group, n = 6) by third-generation lncRNA microarray. We identified 1352 up-regulated and 1624 down-regulated lncRNAs with differential expression (log fold-change > 2...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29310434/in-vitro-and-in-vivo-studies-on-biomedical-magnesium-low-alloying-with-elements-gadolinium-and-zinc-for-orthopaedic-implant-applications
#9
Dong Bian, Jiuxu Deng, Nan Li, Xiao Chu, Yang Liu, Wenting Li, Hong Cai, Peng Xiu, Yu Zhang, Zhenpeng Guan, Yufeng Zheng, Yuhui Kou, Baoguo Jiang, Rongshi Chen
Ternary magnesium alloys with low combined-addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors and cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, with the best in vitro performances, was implanted into Sprague Dawley rats to examine its in vivo degradation performances up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX®, the mischmetal added Mg alloy...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29305859/n-oleoylethanolamide-suppresses-intimal-hyperplasia-after-balloon-injury-in-rats-through-ampk-ppar%C3%AE-pathway
#10
Yun Zhao, Yijun Liu, Zuo Jing, Lu Peng, Peng Jin, Yangbin Lin, Yu Zhou, Lichao Yang, Jie Ren, Qiang Xie, Xin Jin
Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events in the pathological course of restenosis after percutaneous coronary intervention (PCI). N-oleoylethanolamide (OEA) is a bioactive lipid amide released upon dietary fat digestion with many reported actions. However, the effect of OEA on restenosis after vascular injury remains unknown. Here, we investigated the effects of OEA on intimal hyperplasia after balloon injury in vivo, its effect on VSMC proliferation and migration induced by platelet-derived growth factor (PDGF) stimulation in vitro, and the underlying mechanism underlying these effects...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29301759/deletion-of-i%C3%AE%C2%BAb-kinase-%C3%AE-in-smooth-muscle-cells-induces-vascular-calcification-through-%C3%AE-catenin-runt-related-transcription-factor-2-signaling
#11
Isehaq Al-Huseini, Noboru Ashida, Takeshi Kimura
BACKGROUND: Vascular calcification was previously considered as an advanced phase of atherosclerosis; however, recent studies have indicated that such calcification can appear in different situations. Nevertheless, there has been a lack of mechanistic insight to explain the difference. For example, the roles of nuclear factor-κB, a major regulator of inflammation, in vascular calcification are poorly explored, although its roles in atherosclerosis were well documented. Herein, we investigated the roles of nuclear factor-κB signaling in vascular calcification...
January 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29299128/estrogen-modulates-vascular-smooth-muscle-cell-function-through-downregulation-of-sirt1
#12
Chien-Hsing Lee, Sheng-Chiang Su, Chi-Fu Chiang, Chu-Yen Chien, Chia-Chen Hsu, Tzu-Yi Yu, Shih-Ming Huang, Yi-Shing Shieh, Hong-Wei Kao, Chien-Sung Tsai, Yi-Jen Hung, Chih-Yuan Lin
Background: There are sex differences in the incidence and severity of cardiovascular disease. Although an estrogen-mediated vasculoprotective effect is widely accepted, clinical trial results have been conflicting and the detailed mechanisms are still unclear. Sirtuin 1 (SIRT1), a class III histone deacetylase, may protect against vascular aging and atherosclerosis; however, the effects of estrogen on SIRT1 expression and vascular smooth muscle cell (VSMC) behavior remain unknown. Materials and Methods: We ovariectomized (OVX) female, wild-type, C57BL/6J mice, which were randomized into non-estrogen- and estrogen-supplemented groups...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288721/treatment-of-%C3%AE-thujaplicin-counteracts-di-2-ethylhexyl-phthalate-dehp-exposed-vascular-smooth-muscle-activation-inflammation-and-atherosclerosis-progression
#13
Mei Fen Shih, Kuang-Hung Pan, Chia-Chyuan Liu, Chia-Rui Shen, Jong Yuh Cherng
The initiation of atherosclerosis involves up-regulation of molecules such as E-selectin, VCAM-1, and ICAM-1. The progression of atherosclerosis is linked to proliferation and migration of vascular smooth muscle cell via MMP-2 and MMP-9 activities. However, the etiology of atherosclerosis concerning plasticizers is unknown. We evaluated β-thujaplicin in preventing the development of atherosclerosis in a model induced by pro-inflammatory cytokines. Moreover, we established a new atherosclerosis model in vascular smooth muscle cells (VSMC) exposed to a common contact plasticizer, di(2-ethylhexyl)phthalate (DEHP)...
December 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29286083/kdm3a-inhibition-attenuates-high-concentration-insulin%C3%A2-induced-vascular-smooth-muscle-cell-injury-by-suppressing-mapk-nf%C3%A2-%C3%AE%C2%BAb-pathways
#14
Bo-Fang Zhang, Hong Jiang, Jing Chen, Xin Guo, Qi Hu, Shuo Yang
Previous studies have indicated that lysine (K)‑specific demethylase 3A (KDM3A) is associated with diverse diabetes‑associated cardiovascular complications in response to high glucose levels. However, the effects of KDM3A on the pathological progression of cardiovascular injuries in response to high insulin levels remain unknown. The present study aimed to explore whether KDM3A knockdown may attenuate high insulin‑induced vascular smooth muscle cell (VSMC) dysfunction, and to further investigate the underlying mechanisms...
December 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29284006/sm22%C3%AE-suppresses-cytokine-induced-inflammation-and-the-transcription-of-nf-%C3%AE%C2%BAb-inducing-kinase-nik-by-modulating-srf-transcriptional-activity-in-vascular-smooth-muscle-cells
#15
Xiaohua Dai, Devi Thiagarajan, Jingye Fang, Jianbin Shen, Neeraja Priyanka Annam, Zhao Yang, Hong Jiang, Donghong Ju, Youming Xie, Kezhong Zhang, Yan Yuan Tseng, Zhe Yang, Arun K Rishi, Hui J Li, Maozhou Yang, Li Li
Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows that depletion of SM22α (aka SM22, Transgelin, an actin cytoskeleton binding protein) promotes inflammation in SMCs by activating NF-κB signal pathways both in cultured VSMCs and in response to vascular injury. The goal of this study is to investigate the underlying molecular mechanisms whereby SM22 suppresses NF-κB signaling pathways under inflammatory condition...
2017: PloS One
https://www.readbyqxmd.com/read/29279317/ak098656-a-novel-vascular-smooth-muscle-cell-dominant-long-noncoding-rna-promotes-hypertension
#16
Ling Jin, Xianjuan Lin, Lei Yang, Xiaofang Fan, Wenjie Wang, Shuangyue Li, Jing Li, Xiaoyan Liu, Minghui Bao, Xiao Cui, Jichun Yang, Qinghua Cui, Bin Geng, Jun Cai
Recent studies reported some long noncoding RNAs (lncRNAs)-mediated vascular smooth muscle cells (VSMCs) phenotypic switch, which was a common pathophysiological process of vascular diseases. However, whether human-specific expressed lncRNAs would modulate VSMCs phenotype and participate into the pathogenesis of essential hypertension remains unclear. By comparing the circulating lncRNAs expression profiles between hypertensive patients and healthy controls, we identified a lncRNA-AK098656, strongly upregulated in the plasma of hypertensive patients, and predominantly expressed in VSMCs...
December 26, 2017: Hypertension
https://www.readbyqxmd.com/read/29277292/resveratrol-attenuates-hyperproliferation-of-vascular-smooth-muscle-cells-from-spontaneously-hypertensive-rats-role-of-ros-and-ros-mediated-cell-signaling
#17
Sara Almajdoob, Ekhtear Hossain, Madhu B Anand-Srivastava
Resveratrol, a natural polyphenolic compound has been reported to attenuate angiotensin II -induced vascular smooth muscle cell (VSMC) hypertrophy; however, whether resveratrol could also inhibit hyperproliferation of VSMC from spontaneously hypertensive rats (SHR) is unexplored. The present study investigates the effect of resveratrol on hyperproliferation of VSMC from SHR and the underlying molecular mechanisms responsible for this response. For these studies, aortic VSMC from SHR and Wistar-Kyoto (WKY) rats were used...
December 19, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29274344/calcium-phosphate-particles-stimulate-interleukin-1%C3%AE-release-from-human-vascular-smooth-muscle-cells-a-role-for-spleen-tyrosine-kinase-and-exosome-release
#18
Yana Dautova, Alexander N Kapustin, Kevin Pappert, Matthias Epple, Hanneke Okkenhaug, Simon J Cook, Catherine M Shanahan, Martin D Bootman, Diane Proudfoot
AIMS: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase-1 activation and secretion of mature interleukin-1β (IL-1β). Given the close association of small CaP particles with vascular smooth muscle cells (VSMCs) in atherosclerotic fibrous caps, we aimed to determine if CaP particles affected pro-inflammatory signalling in human VSMCs...
December 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29262411/nlrp3-gene-deletion-attenuates-angiotensin-ii-induced-phenotypic-transformation-of-vascular-smooth-muscle-cells-and-vascular-remodeling
#19
Xing-Sheng Ren, Ying Tong, Li Ling, Dan Chen, Hai-Jian Sun, Hong Zhou, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
BACKGROUND/AIMS: Angiotensin (Ang) II plays vital roles in vascular inflammation and remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells (VSMCs) is a major initiating factor for vascular remodeling. The present study was designed to determine the roles of NLRP3 inflammasome activation in Ang II-induced VSMC phenotypic transformation and vascular remodeling in hypertension. METHODS: Primary VSMCs from the aorta of NLRP3 knockout (NLRP3-/-) mice and wild-type (WT) mice were treated with Ang II for 24 h...
December 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29250830/suppressive-activities-and-mechanisms-of-ugonin-j-on-vascular-smooth-muscle-cells-and-balloon-angioplasty-induced-neointimal-hyperplasia
#20
Chun-Hsu Pan, Pei-Chuan Li, Yi-Chung Chien, Wan-Ting Yeh, Chih-Chuang Liaw, Ming-Jyh Sheu, Chieh-Hsi Wu
Neointimal hyperplasia (or restenosis) is primarily attributed to excessive proliferation and migration of vascular smooth muscle cells (VSMCs). In this study, we investigated the inhibitory effects and mechanisms of ugonin J on VSMC proliferation and migration as well as neointimal formation. Cell viability and the cell-cycle distribution were, respectively, analyzed using an MTT assay and flow cytometry. Cell migration was examined using a wound-healing analysis and a transwell assay. Protein expressions and gelatinase activities were, respectively, measured using Western blot and gelatin zymography...
December 18, 2017: Phytotherapy Research: PTR
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