Yinghong Zhu, Xingxing Jian, Shuping Chen, Gang An, Duanfeng Jiang, Qin Yang, Jingyu Zhang, Jian Hu, Yi Qiu, Xiangling Feng, Jiaojiao Guo, Xun Chen, Zhengjiang Li, Ruiqi Zhou, Cong Hu, Nihan He, Fangming Shi, Siqing Huang, Hong Liu, Xin Li, Lu Xie, Yan Zhu, Lia Zhao, Yichuan Jiang, Jian Li, Jinuo Wang, Lugui Qiu, Xiang Chen, Wei Jia, Yanjuan He, Wen Zhou
The gut microbiome has been found to play a crucial role in the treatment of multiple myeloma (MM), which is still considered incurable due to drug resistance. In previous studies, we demonstrated that intestinal nitrogen-recycling bacteria are enriched in patients with MM. However, their role in MM relapse remains unclear. This study highlights the specific enrichment of Citrobacter freundii (C. freundii) in patients with relapsed MM. Through fecal microbial transplantation experiments, we demonstrate that C...
January 2, 2024: Cell Metabolism