keyword
https://read.qxmd.com/read/38238712/integrative-study-of-pulmonary-microbiome-transcriptome-and-clinical-outcomes-in-mycoplasma-pneumoniae-pneumonia
#21
JOURNAL ARTICLE
Xia Huang, Yingying Luo, Jing Wang, Xuefang Zhang, Lei Chen, Ruxi Wu, Zhengyang Xue, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Deyu Zhao, Feng Liu
BACKGROUND: This study aimed to investigate the interactions among three core elements of respiratory infection-pathogen, lung microbiome, and host response-and their avocation with the severity and outcomes of Mycoplasma pneumoniae pneumonia (MPP) in children. METHODS: We prospectively collected bronchoalveolar lavage fluid from a cohort of 41 children with MPP, including general MPP (GMPP) and complicated MPP (CMPP), followed by microbiome and transcriptomic analyses to characterize the association among pathogen, lung microbiome, and host response and correlate it with the clinical features and outcomes...
January 18, 2024: Respiratory Research
https://read.qxmd.com/read/38233085/rifaximin-treatment-shapes-a-unique-metagenome-metabolism-network-in-patients-with-decompensated-cirrhosis
#22
JOURNAL ARTICLE
Mei-Tong Nie, Pei-Qin Wang, Pei-Mei Shi, Xia-Lu Hong, Xin Zhang, Baoyu Xiang, Menghui Zhang, Wei-Fen Xie
BACKGROUND: Patients with decompensated cirrhosis face poor prognosis and increased mortality risk. Rifaximin, a non-absorbable antibiotic, has been shown to have beneficial effects in preventing complications and improving survival in these patients. However, the underlying mechanisms of rifaximin's effects remain unclear. METHODS: We obtained fecal samples from decompensated cirrhotic patients undergoing rifaximin treatment and controls, both at baseline and after 6 months of treatment...
January 17, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38227477/integrated-multi-omics-profiling-highlights-the-benefits-of-resveratrol-hydroxypropyl-%C3%AE-cyclodextrin-inclusion-complex-for-a53t-transgenic-mice-through-the-microbiota-gut-brain-axis
#23
JOURNAL ARTICLE
Xiaodong Sun, Shenglan Feng, Bingqing Qin, Junjie Ye, Lixia Xie, Jianjun Gui, Ming Sang
Parkinson's disease (PD) is a neurological disorder characterized by motor and gastrointestinal dysfunctions. Resveratrol is a potent antioxidant and anti-inflammatory phytoalexin known for its health-promoting benefits. However, little is known about its potential in treating PD by modulating the microbial gut-brain axis, and its clinical application has been limited due to poor water solubility, rapid metabolism, and limited systemic bioavailability. Our study aimed to evaluate the therapeutic potential of RHSD, a resveratrol-cyclodextrin inclusion complex, in treating PD through the gut-brain axis in human SNCA-transgenic (A53T) mice PD models...
January 16, 2024: Food & Function
https://read.qxmd.com/read/38225124/integrating-shotgun-metagenomics-and-metabolomics-to-elucidate-the-dynamics-of-microbial-communities-and-metabolites-in-fine-flavor-cocoa-fermentation-in-hainan
#24
JOURNAL ARTICLE
Haode Chang, Chunhe Gu, Mengrui Wang, Ziqing Chang, Junping Zhou, Mingzhe Yue, Junxia Chen, Xiaowei Qin, Zhen Feng
The aim of this study was to investigate the dynamic profile of microorganisms and metabolites in Hainan Trinitario cocoa during a six-day spontaneous box fermentation process. Shotgun metagenomic and metabolomic approaches were employed for this investigation. The potential metabolic functions of microorganisms in cocoa fermentation were revealed through a joint analysis of microbes, functional genes, and metabolites. During the anaerobic fermentation phase, Hanseniaspora emerged as the most prevalent yeast genus, implicated in pectin decomposition and potentially involved in glycolysis and starch and sucrose metabolism...
February 2024: Food Research International
https://read.qxmd.com/read/38220023/methane-and-nitrous-oxide-emissions-and-related-microbial-communities-from-mangrove-stems-on-qi-ao-island-pearl-river-estuary-in-china
#25
JOURNAL ARTICLE
Xiaolin Liao, Ying Wang, Saadatullah Malghani, Xudong Zhu, Wenqi Cai, Zhangcai Qin, Fan Wang
Mangrove forests, crucial carbon-rich ecosystems, are increasingly vulnerable to soil carbon loss and greenhouse gas (GHG) emissions due to human disturbance. However, the contribution of mangrove trees to GHG emissions remains poorly understood. This study monitored CO2 , CH4 , and N2 O fluxes from the stems of two mangrove species, native Kandelia obovata (KO) and exotic Sonneratia apetala (SA), at three heights (0.7 m, 1.2 m, and 1.7 m) during the dry winter period on Qi'ao Island, Pearl River Estuary, China...
January 12, 2024: Science of the Total Environment
https://read.qxmd.com/read/38219581/low-density-polyethylene-enhances-the-disturbance-of-microbiome-and-antibiotic-resistance-genes-transfer-in-soil-earthworm-system-induced-by-pyraclostrobin
#26
JOURNAL ARTICLE
Yirong Zhang, Kaikai Qin, Chenglan Liu
Non-antibiotic chemicals in farmlands, including microplastics (MPs) and pesticides, have the potential to influence the soil microbiome and the dissemination of antibiotic resistance genes (ARGs). Despite this, there is limited understanding of the combined effects of MPs and pesticides on microbial communities and ARGs transmission in soil ecosystems. In this study, we observed that low-density polyethylene (LDPE) microplastic enhance the accumulation of pyraclostrobin in earthworms, resulting in reduced weight and causing severe oxidative damage...
January 8, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38184271/berberine-regulates-intestinal-microbiome-and-metabolism-homeostasis-to-treat-ulcerative-colitis
#27
JOURNAL ARTICLE
Tao Yang, Niping Qin, Fahui Liu, Yihan Zhao, Wanning Liu, Daiming Fan
AIMS: This study aims to investigate the effects of berberine (BBR) on the intestinal microbiome (IM) and serum metabolome in ulcerative colitis (UC). Furthermore, the underlying molecular mechanisms of BBR in treating UC also will be explored systematically. MATERIALS AND METHODS: A multi-omics approach that integrates the 16s rDNA, serum metabolome, transcriptomics and bioinformatics was profiled to investigate the potential effects of BBR on the IM, serum metabolites and metabolic pathways, and gene expression...
January 4, 2024: Life Sciences
https://read.qxmd.com/read/38183402/gut-microbiota-variation-across-generations-regarding-the-diet-and-life-stage-in-harmonia-axyridis-coleoptera-coccinellidae
#28
JOURNAL ARTICLE
Yansong Wang, Ping Gao, Wenquan Qin, Hongran Li, Jie Zheng, Ling Meng, Baoping Li
We attempt to determine the effect of the dietary switch from a native to non-native prey on the gut microbiota in the predaceous ladybird Harmonia axyridis larvae and adults and examine how the dietary effect may vary across generations. We fed H. axyridis with different diets, native aphid Megoura japonica (Matsumura) versus non-native mealybug Phenacoccus solenopsis (Tinsley), for 5 generations and sequenced microbes in the gut of the 3rd instar larvae and adults of the 1st, 3rd, and 5th generations. In addition, we identified microbes in M...
January 6, 2024: Insect Science
https://read.qxmd.com/read/38174936/evolutionary-radiation-and-microbial-community-dynamics-shape-the-thermal-tolerance-of-fungiidae-in-the-southern-south-china-sea
#29
JOURNAL ARTICLE
Yuxin Wei, Biao Chen, Kefu Yu, Zhiheng Liao, Xiaopeng Yu, Zhenjun Qin, Zeming Bao, Lijia Xu, Yongzhi Wang
Coral reefs are facing significant threats due to global warming. The heat tolerance of coral holobionts depends on both the coral host and its microbiome. However, the association between coral evolutionary radiation and interspecific differences in microbial communities remains unclear. In this study, we investigated the role of evolutionary radiation and microbial community dynamics in shaping the thermal acclimation potential of Fungiidae in the Sanjiao Reef of the southern South China Sea. The study's results suggest that evolutionary radiation enhances the thermal tolerance of Fungiidae...
January 4, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38173170/the-short-term-impact-of-comprehensive-caries-treatment-on-the-supragingival-microbiome-of-severe-early-childhood-caries
#30
JOURNAL ARTICLE
Jing Tian, Bingqian Zhao, Jingyan Wang, Wenbin Du, Wenli Ma, Bin Xia, He Xu, Tsute Chen, Xuesong He, Man Qin
BACKGROUND: Children affected by severe early childhood caries (S-ECC) usually need comprehensive caries treatment due to the extensive of caries. How the oral microbiome changes after caries therapy within the short-term warrant further study. AIM: This study aimed to investigate the short-term impact of comprehensive caries treatment on the supragingival plaque microbiome of S-ECC children. DESIGN: Thirty-three children aged 2-4 years with severe caries (dt > 7) were recruited...
January 3, 2024: International Journal of Paediatric Dentistry
https://read.qxmd.com/read/38142919/dietary-fibre-confers-therapeutic-effects-in-a-preclinical-model-of-huntington-s-disease
#31
JOURNAL ARTICLE
Carolina Gubert, Geraldine Kong, Callum Costello, Cameron D Adams, Bethany A Masson, Wendy Qin, Jocelyn Choo, Vinod K Narayana, Geraint Rogers, Thibault Renoir, John B Furness, Anthony J Hannan
Huntington's disease (HD) is a neurodegenerative disorder involving psychiatric, cognitive, and motor deficits, as well as peripheral symptoms, including gastrointestinal dysfunction. The R6/1 HD mouse model expresses a mutant human huntingtin transgene and has been shown to provide an accurate disease model. Recent evidence of gut microbiome disruption was shown in preclinical and clinical HD. Therefore, we aimed to assess the potential role of gut microbial modulation in the treatment of HD. The R6/1 HD mice and wild-type littermate controls were randomised to receive diets containing different amounts of fibre: high-fibre (10 % fibre), control (5 % fibre), or zero-fibre (0 % fibre), from 6 to 20 weeks of age...
December 22, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38130871/biomarkers-associated-with-the-pathogenesis-of-alzheimer-s-disease
#32
REVIEW
Hui Wang, Mengli Sun, Wenhui Li, Xing Liu, Mengfan Zhu, Hua Qin
Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious onset. Due to the complexity of the pathogenesis of AD and different pathological changes, the clinical phenotypes of dementia are diverse, and these pathological changes also interact with each other. Therefore, it is of great significance to search for biomarkers that can diagnose these pathological changes to improve the ability to monitor the course of disease and treat the disease. The pathological mechanism hypothesis with high recognition of AD mainly includes the accumulation of β-amyloid (Aβ) around neurons and hyperphosphorylation of tau protein, which results in the development of neuronal fiber tangles (NFTs) and mitochondrial dysfunction...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38122845/optimum-doses-and-forms-of-selenium-maintaining-reproductive-health-via-regulating-homeostasis-of-gut-microbiota-and-testicular-redox-inflammation-cell-proliferation-and-apoptosis-in-roosters
#33
JOURNAL ARTICLE
Yi-Qin Yan, Meng Liu, Ze-Jing Xu, Zi-Jian Xu, Yu-Xuan Huang, Xiao-Min Li, Chao-Jiang Chen, Gang Zuo, Jia-Cheng Yang, Xin Gen Lei, Lv-Hui Sun
BACKGROUND: There is a U-shaped relationship between dietary selenium (Se) ingestion and optimal sperm quality. OBJECTIVES: This study aims to investigate the optimal dietary dose and forms of Se for sperm quality of breeder roosters and the relevant mechanisms. METHODS: In Expt. 1, 18-week-old Jingbai laying breeder roosters were fed a Se-deficient base diet (BD, 0.06 mg Se/kg), or the BD + 0.1, 0.2, 0.3, 0.4, 0.5 or 1.0 mg Se/kg for 9 weeks...
December 18, 2023: Journal of Nutrition
https://read.qxmd.com/read/38115159/gut-microbiota-affects-the-estrus-return-of-sows-by-regulating-the-metabolism-of-sex-steroid-hormones
#34
JOURNAL ARTICLE
Min Liu, Jia Zhang, Yunyan Zhou, Shuqi Xiong, Mengqing Zhou, Lin Wu, Qin Liu, Zhe Chen, Hui Jiang, Jiawen Yang, Yuxin Liu, Yaxiang Wang, Congying Chen, Lusheng Huang
BACKGROUND: Sex hormones play important roles in the estrus return of post-weaning sows. Previous studies have demonstrated a complex and bi-directional regulation between sex hormones and gut microbiota. However, the extent to which the gut microbiota affects estrus return of post-weaning sows is largely unknown. RESULTS: In this study, we first screened 207 fecal samples from well-phenotyped sows by 16S rRNA gene sequencing and identified significant associations between microbes and estrus return of post-weaning sows...
December 20, 2023: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/38113887/targeting-gut-microbial-nitrogen-recycling-and-cellular-uptake-of-ammonium-to-improve-bortezomib-resistance-in-multiple-myeloma
#35
JOURNAL ARTICLE
Yinghong Zhu, Xingxing Jian, Shuping Chen, Gang An, Duanfeng Jiang, Qin Yang, Jingyu Zhang, Jian Hu, Yi Qiu, Xiangling Feng, Jiaojiao Guo, Xun Chen, Zhengjiang Li, Ruiqi Zhou, Cong Hu, Nihan He, Fangming Shi, Siqing Huang, Hong Liu, Xin Li, Lu Xie, Yan Zhu, Lia Zhao, Yichuan Jiang, Jian Li, Jinuo Wang, Lugui Qiu, Xiang Chen, Wei Jia, Yanjuan He, Wen Zhou
The gut microbiome has been found to play a crucial role in the treatment of multiple myeloma (MM), which is still considered incurable due to drug resistance. In previous studies, we demonstrated that intestinal nitrogen-recycling bacteria are enriched in patients with MM. However, their role in MM relapse remains unclear. This study highlights the specific enrichment of Citrobacter freundii (C. freundii) in patients with relapsed MM. Through fecal microbial transplantation experiments, we demonstrate that C...
January 2, 2024: Cell Metabolism
https://read.qxmd.com/read/38104809/granular-bacterial-inoculant-alters-the-rhizosphere-microbiome-and-soil-aggregate-fractionation-to-affect-phosphorus-fractions-and-maize-growth
#36
JOURNAL ARTICLE
Xiaofan Xie, Yang Liu, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Ailing Ye, Qin Zhou, Yun Wang, Meilan Zhang, Yubao Zhang, Zhongping Li, Lam-Son Phan Tran, Ruoyu Wang
The constraint of phosphorus (P) fixation on crop production in alkaline calcareous soils can be alleviated by applying bioinoculants. However, the impact of bacterial inoculants on this process remains inadequately understood. Here, a field study was conducted to investigate the effect of a high-concentration, cost-effective, and slow-release granular bacterial inoculant (GBI) on maize (Zea mays L.) plant growth. Additionally, we explored the effects of GBI on rhizosphere soil aggregate physicochemical properties, rhizosphere soil P fraction, and microbial communities within aggregates...
December 15, 2023: Science of the Total Environment
https://read.qxmd.com/read/38101145/associations-between-vaginal-microbiota-and-endometrial-polypoid-lesions-in-women-of-reproductive-age-a-cross-sectional-study
#37
JOURNAL ARTICLE
Zhaomei Tian, Maoning Zhao, Xinlei Sui, Xiao Li, Lang Qin, Zi-Jiang Chen, Shigang Zhao, Han Zhao
RESEARCH QUESTION: What are the different characteristics of vaginal microbial composition between patients with endometrial polypoid lesions and controls? DESIGN: This cohort study compared the pre-operative microbial compositions of vaginal samples in a cohort of 703 women with endometrial polypoid lesions [293 and 410 women diagnosed and not diagnosed with polyps pathologically (polyps group and not-polyps group, respectively] and 703 women in the control group...
October 11, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38096593/increased-s-aureus-colonization-and-reduced-antimicrobial-peptide-expression-in-erythrodermic-psoriasis
#38
JOURNAL ARTICLE
Yuhua Liu, Xiaoyan Wu, Pengfei Song, Leying Liu, Xinyu Zhong, Qin He, Zhenying Zhang
BACKGROUND: Erythrodermic psoriasis (EP) is a severe and rare condition characterized by prominent erythema and scaling over 75 % of the body surface area. Unlike psoriasis vulgaris (PV), EP carries high risk of systemic involvement, including superficial skin infections and sepsis, particularly those caused by Staphylococcus aureus. OBJECTIVE: To explore the microecological characteristics of EP and detect the levels of antimicrobial peptides (AMPs) in both skin and serum of EP patients...
December 13, 2023: International Immunopharmacology
https://read.qxmd.com/read/38094621/immune-modulation-of-gut-microbiota-and-its-metabolites-in-chronic-hepatitis-b
#39
REVIEW
Shi-Qin Li, Yue Shen, Jun Zhang, Cheng-Zhao Weng, Sheng-Di Wu, Wei Jiang
The gut microbiota is a diverse ecosystem consisting of 100 trillion microbiomes. The interaction between the host's gut and distal organs profoundly impacts various functions such as metabolism, immunity, neurology, and nutrition within the human body. The liver, as the primary immune organ, plays a crucial role in maintaining immune homeostasis by receiving a significant influx of gut-derived components and toxins. Perturbations in gut microbiota homeostasis have been linked to a range of liver diseases. The advancements in sequencing technologies, such as 16S rRNA and metagenomics, have opened up new avenues for comprehending the intricate physiological interplay between the liver and the intestine...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38064688/astragaloside-iv-alleviates-depression-in-rats-by-modulating-intestinal-microbiota-t-immune-balance-and-metabolome
#40
JOURNAL ARTICLE
Xiaojie Liu, Senyan Wang, Xiaoling Wu, Ziyu Zhao, Chen Jian, Mengyu Li, Xuemei Qin
This study aims to explore the effects of Astragaloside IV (AS-IV) on abnormal behaviors, intestinal microbiota, intestinal T-immune balance, and fecal metabolism of a model of depression in rats. Herein, we integrally applied 16S rRNA sequencing, molecular biological techniques, and 1 H NMR-based fecal metabolomics to demonstrate the antidepression activity of AS-IV. The results suggested that AS-IV regulated the depression-like behaviors of rats, which are presented by an increase of body weight, upregulation of sucrose preference rates, and a decrease of immobility time...
December 8, 2023: Journal of Agricultural and Food Chemistry
keyword
keyword
42798
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.