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https://www.readbyqxmd.com/read/29881345/detection-of-microbial-16s-rrna-gene-in-the-blood-of-patients-with-parkinson-s-disease
#1
Yiwei Qian, Xiaodong Yang, Shaoqing Xu, Chunyan Wu, Nan Qin, Sheng-Di Chen, Qin Xiao
Emerging evidence suggests that the microbiota present in feces plays a role in Parkinson's disease (PD). However, the alterations of the microbiome in the blood of PD patients remain unknown. To test this hypothesis, we conducted this case-control study to explore the microbiota compositions in the blood of Chinese PD patients. Microbiota communities in the blood of 45 patients and their healthy spouses were investigated using high-throughput Illumina HiSeq sequencing targeting the V3-V4 region of 16S ribosomal RNA (rRNA) gene...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29668250/effects-of-baicalein-on-cortical-proinflammatory-cytokines-and-the-intestinal-microbiome-in-senescence-accelerated-mouse-prone-8
#2
Li Gao, Jiaqi Li, Yuzhi Zhou, Xudong Huang, Xuemei Qin, Guanhua Du
Baicalein, a flavonoid derived from the roots of Scutellariae baicalensis Georgi, has shown health benefits for an array of human diseases including dementia. The senescence-accelerated mouse prone 8 (SAMP8) strain is extensively used as a senile dementia model. To further investigate the effects of baicalein in SAMP8 mice, behavioral testing, biochemical detection, and gut microbiota analysis were performed. The results demonstrated that treatment with baicalein ameliorated the senescence status of the SAMP8 mice, as manifested by reducing the grading score of senescence...
April 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29580257/gut-microbiome-modulates-efficacy-of-immune-checkpoint-inhibitors
#3
REVIEW
Ming Yi, Shengnan Yu, Shuang Qin, Qian Liu, Hanxiao Xu, Weiheng Zhao, Qian Chu, Kongming Wu
Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, which led to the limitation of clinical application. Motivated by potent and durable efficacy of ICIs, oncologists endeavor to explore the mechanisms of resistance to ICIs and increase the drug sensitivity. It is known that heterogeneity of gut microbiome in populations may result in different outcomes of therapy...
March 27, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29573223/mycobiota-of-maize-seeds-revealed-by-rdna-its-sequence-analysis-of-samples-with-varying-storage-times
#4
Hui-Qin Xing, Jian-Cang Ma, Bing-Liang Xu, Shu-Wu Zhang, Jin Wang, Li Cao, Xue-Mei Yang
Fungi are an integral component of the plant microbiome. However, the composition and variation in the fungal communities (mycobiota) associated with seeds are poorly understood. In this study, we investigated the mycobiota of 11 maize seed samples with storage times ranging from 6 months to 12 years. Mycobiota were characterized by a culture-based approach, and fungal species were identified through rDNA-ITS sequence analyses. From a total of 169 pure fungal isolates obtained from both the seed surface and internal tissues, we identified 16 distinct species (belonging to 10 genera) associated with maize seeds, all but one of which were ascomycetes...
March 23, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29501802/alteration-of-the-fecal-microbiota-in-chinese-patients-with-parkinson-s-disease
#5
Yiwei Qian, Xiaodong Yang, Shaoqing Xu, Chunyan Wu, Yanyan Song, Nan Qin, Sheng-Di Chen, Qin Xiao
Emerging evidences suggest that gut microbiota dysbiosis plays a role in Parkinson's disease (PD). However, the alterations in fecal microbiome in Chinese PD patients remains unknown. This case-control study was conducted to explore fecal microbiota compositions in Chinese PD patients. Microbiota communities in the feces of 45 patients and their healthy spouses were investigated using high-throughput Illumina Miseq sequencing targeting the V3-V4 region of 16S ribosomal RNA (rRNA) gene. The relationships between fecal microbiota and PD clinical characteristics were analyzed...
May 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29463661/microbial-functional-gene-diversity-predicts-groundwater-contamination-and-ecosystem-functioning
#6
Zhili He, Ping Zhang, Linwei Wu, Andrea M Rocha, Qichao Tu, Zhou Shi, Bo Wu, Yujia Qin, Jianjun Wang, Qingyun Yan, Daniel Curtis, Daliang Ning, Joy D Van Nostrand, Liyou Wu, Yunfeng Yang, Dwayne A Elias, David B Watson, Michael W W Adams, Matthew W Fields, Eric J Alm, Terry C Hazen, Paul D Adams, Adam P Arkin, Jizhong Zhou
Contamination from anthropogenic activities has significantly impacted Earth's biosphere. However, knowledge about how environmental contamination affects the biodiversity of groundwater microbiomes and ecosystem functioning remains very limited. Here, we used a comprehensive functional gene array to analyze groundwater microbiomes from 69 wells at the Oak Ridge Field Research Center (Oak Ridge, TN), representing a wide pH range and uranium, nitrate, and other contaminants. We hypothesized that the functional diversity of groundwater microbiomes would decrease as environmental contamination (e...
February 20, 2018: MBio
https://www.readbyqxmd.com/read/29423379/identification-and-characterization-of-blood-and-neutrophil-associated-microbiomes-in-patients-with-severe-acute-pancreatitis-using-next-generation-sequencing
#7
Qiurong Li, Chenyang Wang, Chun Tang, Xiaofan Zhao, Qin He, Jieshou Li
Infectious complications are a leading cause of death for patients with severe acute pancreatitis (SAP). Yet, our knowledge about details of the blood microbial landscape in SAP patients remains limited. Recently, some studies have reported that the peripheral circulation harbors a diverse bacterial community in healthy and septic subjects. The objective of this study was to examine the presence of the blood bacterial microbiome in SAP patients and its potential role in the development of infectious complications...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29402771/micro-integral-membrane-protein-mimp-a-newly-discovered-anti-inflammatory-protein-of-lactobacillus-plantarum-enhances-the-gut-barrier-and-modulates-microbiota-and-inflammatory-cytokines
#8
Mingming Yin, Xuebing Yan, Wenhao Weng, Yongzhi Yang, Renyuan Gao, Minfeng Liu, Cheng Pan, Qi Zhu, Hao Li, Qing Wei, Tongyi Shen, Yanlei Ma, Huanlong Qin
BACKGROUND/AIMS: Recent studies have demonstrated that the manipulation of the gut microbiome represents a promising treatment for inflammatory bowel disease (IBD). We previously identified micro integral membrane protein (MIMP) as the smallest domain of surface layer protein from Lactobacillus Plantarum. However, the therapeutic relevance of MIMP in IBD remains unknown. METHODS: We initially employed a dextran sodium sulphate (DSS)-induced colitis model and evaluated the effect of MIMP on the inflammation response, intestinal barrier and gut microbiota using histological examination, Fluorescein isothiocyanate-Dextran detection and pyrosequencing analysis respectively...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29361968/an-obesity-associated-gut-microbiome-reprograms-the-intestinal-epigenome-and-leads-to-altered-colonic-gene-expression
#9
Yufeng Qin, John D Roberts, Sara A Grimm, Fred B Lih, Leesa J Deterding, Ruifang Li, Kaliopi Chrysovergis, Paul A Wade
BACKGROUND: The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How the host mediates epigenomic responses to gut microbiota is an emerging area of interest. Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression...
January 23, 2018: Genome Biology
https://www.readbyqxmd.com/read/29291559/spatiotemporal-changes-in-bacterial-community-and-microbial-activity-in-a-full-scale-drinking-water-treatment-plant
#10
Luanfeng Hou, Qin Zhou, Qingping Wu, Qihui Gu, Ming Sun, Jumei Zhang
To gain insight into the bacterial dynamics present in drinking water treatment (DWT) systems, the microbial community and activity in a full-scale DWT plant (DWTP) in Guangzhou, South China, were investigated using Illumina Hiseq sequencing analyses combined with cultivation-based techniques during the wet and dry seasons. Illumina sequencing analysis of 16S rRNA genes revealed a large shift in the proportion of Actinobacteria, Proteobacteria and Firmicutes during the treatment process, with the proportion of Actinobacteria decreased sharply, whereas that of Proteobacteria and Firmicutes increased and predominated in treated water...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29197739/a-meta-analysis-of-the-use-of-probiotics-to-alleviate-depressive-symptoms
#11
REVIEW
Qin Xiang Ng, Christina Peters, Collin Yih Xian Ho, Donovan Yutong Lim, Wee-Song Yeo
INTRODUCTION: Some preclinical and clinical studies have demonstrated the positive impact of probiotic supplementation on depressive symptoms. This paper aims to provide an updated meta-analysis on the topic. METHODS: Using the keywords [probiotics OR gut OR microflora OR microbiome OR bacteria OR yeast OR yoghurt OR lactobacillus OR bifidobacterium] AND [mood OR depression OR MDD OR suicide], a preliminary search on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR) and Cochrane Field for Complementary Medicine database yielded 917 papers published in English between 1-Jan-1960 and 1-June-2017...
March 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161429/crosstalk-between-the-microbiome-and-epigenome-messages-from-bugs
#12
REVIEW
Yufeng Qin, Paul A Wade
Mammals exist in a complicated symbiotic relationship with their gut microbiome, which is postulated to have broad impacts on host health and disease. As omics-based technologies have matured, the potential mechanisms by which the microbiome affects host physiology are being addressed. The gut microbiome, which provides environmental cues, can modify host cell responses to stimuli through alterations in the host epigenome and, ultimately, gene expression. Increasing evidence highlights microbial generation of bioactive compounds that impact the transcriptional machinery in host cells...
February 1, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29117868/correction-to-quantitative-metagenomics-reveals-unique-gut-microbiome-biomarkers-in-ankylosing-spondylitis
#13
Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Emmanuelle Le Chatelier, Zhixing He, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Haichang Li, Chunyan Wu, Changfeng Hu, Qian Xu, Jia Zhou, Shunfeng Cai, Dawei Wang, Yun Huang, Maxime Breban, Nan Qin, Stanislav Dusko Ehrlich
Upon publication of the original article [1], it was noted that references 11 and 22 were miscited in the reference list.
November 8, 2017: Genome Biology
https://www.readbyqxmd.com/read/29036812/altered-gut-microbiota-in-a-mouse-model-of-alzheimer-s-disease
#14
Ling Zhang, Ying Wang, Xia Xiayu, Changhua Shi, Wei Chen, Nan Song, Xinjing Fu, Rui Zhou, Yan-Feng Xu, Lan Huang, Hua Zhu, Yunlin Han, Chuan Qin
The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course of alterations in the gut microbiota, and their effects on AD pathology remain uncertain. Herein, we compared the fecal microbiomes and fecal short chain fatty acid composition (SCFAs) between wild-type and AD model mice at different ages under strictly controlled specific pathogen free conditions, and also conducted microscopic investigations of intestinal structures...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28932895/taxonomic-and-functional-analyses-of-the-supragingival-microbiome-from-caries-affected-and-caries-free-hosts
#15
Jinzhi He, Qichao Tu, Yichen Ge, Yujia Qin, Bomiao Cui, Xiaoyu Hu, Yuxia Wang, Ye Deng, Kun Wang, Joy D Van Nostrand, Jiyao Li, Jizhong Zhou, Yan Li, Xuedong Zhou
Caries is one of the most prevalent and costly infectious diseases affecting humans of all ages. It is initiated by cariogenic supragingival dental plaques forming on saliva-coated tooth surfaces, yet the etiology remains elusive. To determine which microbial populations may predispose a patient to caries, we report here an in-depth and comprehensive view of the microbial community associated with supragingival dental plaque collected from the healthy teeth of caries patients and healthy adults. We found that microbial communities from caries patients had a higher evenness and inter-individual variations but simpler ecological networks compared to healthy controls despite the overall taxonomic structure being similar...
February 2018: Microbial Ecology
https://www.readbyqxmd.com/read/28864077/phenotype-and-antimicrobial-activity-of-th17-cells-induced-by-propionibacterium-acnes-strains-associated-with-healthy-and-acne-skin
#16
George W Agak, Stephanie Kao, Kelsey Ouyang, Min Qin, David Moon, Ahsan Butt, Jenny Kim
Studies of the human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. However, the immune phenotype and functions of T helper type 17 (Th17) cells induced by healthy (PH ) versus acne (PA ) skin-associated P. acnes strains are currently unknown. We stimulated peripheral blood mononuclear cells from healthy donors and observed that PA strains induce higher IL-17 levels than PH strains. We next generated PH and PA strain-specific Th17 clones and show that P...
February 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28859695/learning-microbial-community-structures-with-supervised-and-unsupervised-non-negative-matrix-factorization
#17
Yun Cai, Hong Gu, Toby Kenney
BACKGROUND: Learning the structure of microbial communities is critical in understanding the different community structures and functions of microbes in distinct individuals. We view microbial communities as consisting of many subcommunities which are formed by certain groups of microbes functionally dependent on each other. The focus of this paper is on methods for extracting the subcommunities from the data, in particular Non-Negative Matrix Factorization (NMF). Our methods can be applied to both OTU data and functional metagenomic data...
August 31, 2017: Microbiome
https://www.readbyqxmd.com/read/28814344/microbial-phylogeny-determines-transcriptional-response-of-resistome-to-dynamic-composting-processes
#18
Cheng Wang, Da Dong, P J Strong, Weijing Zhu, Zhuang Ma, Yong Qin, Weixiang Wu
BACKGROUND: Animal manure is a reservoir of antibiotic resistance genes (ARGs) that pose a potential health risk globally, especially for resistance to the antibiotics commonly used in livestock production (such as tetracycline, sulfonamide, and fluoroquinolone). Currently, the effects of biological treatment (composting) on the transcriptional response of manure ARGs and their microbial hosts are not well characterized. Composting is a dynamic process that consists of four distinct phases that are distinguished by the temperature resulting from microbial activity, namely the mesophilic, thermophilic, cooling, and maturing phases...
August 16, 2017: Microbiome
https://www.readbyqxmd.com/read/28802277/microbiome-in-lung-explants-of-idiopathic-pulmonary-fibrosis-a-case-control-study-in-patients-with-end-stage-fibrosis
#19
LETTER
Georgios D Kitsios, Mauricio Rojas, Daniel J Kass, Adam Fitch, John C Sembrat, Shulin Qin, Kristen L Veraldi, Kevin F Gibson, Kathleen Lindell, Joseph M Pilewski, Barbara Methe, Kelvin Li, John McDyer, Bryan J McVerry, Alison Morris
The microbiome has been proposed to play a role in the progression of idiopathic pulmonary fibrosis (IPF) based on bronchoalveolar lavage analyses, but the microbiome of lung tissue in IPF has not been explored. In a case-control study of lung explants analysed by 16S rRNA gene sequencing, we could not reliably detect bacterial DNA in basilar tissue samples from patients with either chronic or acute exacerbations of IPF, in contrast to control candidate-donor lungs or cystic fibrosis explants. Thus, our data do not indicate microbiome alterations in regions of IPF lung with advanced fibrosis...
May 2018: Thorax
https://www.readbyqxmd.com/read/28750650/quantitative-metagenomics-reveals-unique-gut-microbiome-biomarkers-in-ankylosing-spondylitis
#20
Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Emmanuelle Le Chatelier, Zhixing He, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Haichang Li, Chunyan Wu, Changfeng Hu, Qian Xu, Jia Zhou, Shunfeng Cai, Dawei Wang, Yun Huang, Maxime Breban, Nan Qin, Stanislav Dusko Ehrlich
BACKGROUND: The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing spondylitis may be a microbiome-driven disease. RESULTS: To investigate the relationship between the gut microbiome and ankylosing spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals...
July 27, 2017: Genome Biology
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