keyword
https://read.qxmd.com/read/38486697/the-causality-between-gut-microbiome-and-chronic-regional-pain-a-mendelian-randomization-analysis
#1
JOURNAL ARTICLE
Qing-Ao Xiao, Lei Qin, Jing Yu, Yin-Tao Hu, Lin-Feng Ai, De-Cheng Wang, Xuan Xia, Xiao-Lin Zhang
BACKGROUND: Numerous investigations have underscored the causal effect between chronic pain (CP) and gut microbiota, jointly contributing to the onset and development of widespread CP. Nonetheless, there was still uncertainty about the causal effect between gut microbiota and chronic regional pain (CRP). METHODS: Genome-wide association study (GWAS) summary data of gut microbial taxa (MiBioGen Consortium: 211 microbiotas and the Dutch Microbiome Project: 207 microbiotas) and eight types of CRP were used to reveal the causal effect between persistent pain in a specific region of the body and gut microbiota...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38446304/gastrointestinal-characteristics-of-constipation-from-the-perspectives-of-microbiome-and-metabolome
#2
JOURNAL ARTICLE
Huimin Wang, Di Zhao, Senyan Wang, Huanle Liu, Sijun Zhao, Zhenyu Li, Xuemei Qin, Xiaojie Liu
BACKGROUND: Constipation is one of the most common gastrointestinal complaints. Yet, the underlying mechanisms of constipation remain to be explored deeply. Integration of microbiome and metabolome is powerful and promising to demonstrate characteristics of constipation. AIM OF STUDY: This study aimed to characterize intestinal microbiome and metabolome of constipation. In addition, this study revealed the correlations among behaviors, intestinal microbiota, and metabolites interrupted by constipation...
March 6, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38445866/the-microbiome-dynamics-and-interaction-of-endosymbiotic-symbiodiniaceae-and-fungi-are-associated-with-thermal-bleaching-susceptibility-of-coral-holobionts
#3
JOURNAL ARTICLE
Biao Chen, Yuxin Wei, Kefu Yu, Yanting Liang, Xiaopeng Yu, Zhiheng Liao, Zhenjun Qin, Lijia Xu, Zeming Bao
The thermal bleaching percentage of coral holobionts shows interspecific differences under heat-stress conditions, which are closely related to the coral-associated microbiome. However, the ecological effects of community dynamics and interactions between Symbiodiniaceae and fungi on coral thermal bleaching susceptibility remain unclear. In this study, we analyzed the diversity, community structure, functions, and potential interaction of Symbiodiniaceae and fungi among 18 coral species from a high thermal bleaching risk atoll using next-generation sequencing...
March 6, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38429791/impact-of-hyperoxia-on-the-gut-during-critical-illnesses
#4
REVIEW
Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen, Zhouxiong Xing
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized hyperoxia in the lower body from peripheral venoarterial (VA) ECMO. Consequently, this exposes the gastrointestinal tract to excessive oxygen levels. Hyperoxia can trigger organ damage due to the overproduction of reactive oxygen species and is associated with increased mortality. The gut and gut microbiome play pivotal roles in critical illnesses and even small variations in oxygen levels can have a dramatic influence on the physiology and ecology of gut microbes...
March 1, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38423169/prevotella-a-dominant-bacterium-in-young-people-with-stage-%C3%A2-periodontitis-related-to-the-arachidonic-acid-metabolism-pathway
#5
JOURNAL ARTICLE
Qin Ye, Yaqiong Zhao, Jie Zhao, Zeyue Ouyang, Yao Feng, Jing Hu, Xiaolin Su, Ningxin Chen, Yun Chen, Li Tan, Yunzhi Feng, Yue Guo
OBJECTS: As periodontitis progresses, the oral microbiome changes dynamically. The aim of this study was to evaluate the dominant bacteria of adults with stage III periodontitis and investigate potential pathways related to the dominant bacteria. MATERIALS AND METHODS: 16S rRNA sequencing was carried out to detect the differences in the oral bacteria between adult with stage Ⅰ and stage Ⅲ periodontitis and find the dominant bacteria in each group. The inhibitor of the predominant pathway for stage Ⅲ periodontitis was used to investigate the role of the dominant bacteria in periodontitis in vivo and in vitro...
February 27, 2024: Microbes and Infection
https://read.qxmd.com/read/38422770/effect-of-the-pseudopleuronectes-americanus-derived-pleurocidin-on-dss-induced-ulcerative-colitis-in-mice-and-its-preliminary-molecular-mechanisms
#6
JOURNAL ARTICLE
Keyi Nong, Zhineng Liu, Xinyun Qin, Wanyan Chen, Bin Zhang, Yijia Wu, Zihan Wang, Xin Fang, Youming Liu, Xuemei Wang, Huiyu Shi, Haiwen Zhang
Pleurocidin is an antimicrobial peptide derived from the mucous membranes of the skin or intestinal secretions of Pseudopleuronectes americanus that has antimicrobial and immunomodulatory activities. Ulcerative colitis is recognized as a widespread human disease that may be influenced by environmental and genetic factors. Evidence emphasizes the critical role of the gut microbiota in UC. Synthetic Pleurocidin was analyzed by a combination of liquid chromatography and mass spectrometry. Pleurocidin pharmacological effects were evaluated by DAI score, colon histological score, cytokine levels, and tight junction protein expression in mice...
February 28, 2024: International Immunopharmacology
https://read.qxmd.com/read/38387127/integrated-uhplc-ms-untargeted-metabolomics-and-gut-microbe-metabolism-pathway-targeted-metabolomics-to-reveal-the-prevention-mechanism-of-gushudan-on-kidney-yang-deficiency-syndrome-rats
#7
JOURNAL ARTICLE
Ling Xin, Mengxin Ren, Yanwei Lou, Huawen Yin, Feng Qin, Zhili Xiong
Gushudan (GSD) was a traditional Chinese prescription with the remarkable effect of kidney-tonifying and bone-strengthening. However, the potential prevention mechanisms of the GSD on kidney-yang-deficiency-syndrome (KYDS) and its regulation on gut microbe metabolism still need to be further systematically investigated. This study established untargeted urinary metabolomics based on RP/HILIC-UHPLC-Q-Orbitrap HRMS and combined with multivariate statistical analysis to discover differential metabolites and key metabolic pathways...
February 20, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38376235/metagenomic-exploration-of-the-rhizosphere-soil-microbial-community-and-their-significance-in-facilitating-the-development-of-wild-simulated-ginseng
#8
JOURNAL ARTICLE
Jiaquan Huang, Yaxin Wu, Qiandi Gao, Xiaojie Li, Yunyan Zeng, Yipeng Guo, Heqian Zhang, Zhiwei Qin
Panax ginseng, a prized medicinal herb, has faced increasingly challenging field production due to soil degradation and fungal diseases in Northeast China. Wild-simulated cultivation has prevailed because of its sustainable soil management and low disease incidence. Despite the recognized benefits of rhizosphere microorganisms in ginseng cultivation, their genomic and functional diversity remain largely unexplored. In this work, we utilized shotgun metagenomic analysis to reveal that Pseudomonadota, Actinomycetota, and Acidobacteriota were dominant in the ginseng rhizobiome and recovered 14 reliable metagenome-assembled genomes...
February 20, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38367621/donor-recipient-intermicrobial-interactions-impact-transfer-of-subspecies-and-fecal-microbiota-transplantation-outcome
#9
JOURNAL ARTICLE
Qiyi Chen, Chunyan Wu, Jinfeng Xu, Chen Ye, Xiang Chen, Hongliang Tian, Naixin Zong, Shaoyi Zhang, Long Li, Yuan Gao, Di Zhao, Xiaoqiong Lv, Qilin Yang, Le Wang, Jiaqu Cui, Zhiliang Lin, Jubao Lu, Rong Yang, Fang Yin, Nan Qin, Ning Li, Qian Xu, Huanlong Qin
Studies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with autism spectrum disorder (ASD) who had gastrointestinal comorbidities and underwent encapsulated FMT (Chinese Clinical Trial: 2100043906)...
February 12, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38366934/a-quantitative-survey-of-the-blueberry-vaccinium-spp-culturable-nectar-microbiome-variation-between-cultivars-locations-and-farm-management-approaches
#10
JOURNAL ARTICLE
Caitlin C Rering, Arthur B Rudolph, Qin-Bao Li, Quentin D Read, Patricio R Muñoz, John J Ternest, Charles T Hunter
Microbes in floral nectar can impact both their host plants and floral visitors, yet little is known about the nectar microbiome of most pollinator-dependent crops. In this study, we examined the abundance and composition of the fungi and bacteria inhabiting Vaccinium spp. nectar, as well as nectar volume and sugar concentrations. We compared wild V. myrsinites with two field-grown V. corymbosum cultivars collected from two organic and two conventional farms. Differences in nectar traits and microbiomes were identified between V...
February 16, 2024: FEMS Microbiology Ecology
https://read.qxmd.com/read/38347014/effects-of-radiofrequency-field-from-5g-communication-on-fecal-microbiome-and-metabolome-profiles-in-mice
#11
JOURNAL ARTICLE
Xing Wang, Guiqiang Zhou, Jiajin Lin, Tongzhou Qin, Junze Du, Ling Guo, Panpan Lai, Yuntao Jing, Zhaowen Zhang, Yan Zhou, Guirong Ding
With the rapid development of 5G networks, the influence of the radiofrequency field (RF) generated from 5G communication equipment on human health is drawing increasing attention in public. The study aimed at assessing the effects of long-term exposure to 4.9 GHz (one of the working frequencies of 5G communication) RF field on fecal microbiome and metabolome profiles in adult male C57BL/6 mice. The animals were divided into Sham group and radiofrequency group (RF group). For RF group, the mice were whole body exposed to 4...
February 12, 2024: Scientific Reports
https://read.qxmd.com/read/38346646/characterization-of-microbiome-metabolome-immunity-in-depressed-rats-with-divergent-responses-to-paroxetine
#12
JOURNAL ARTICLE
Xiaojie Liu, Mengyu Li, Chen Jian, Xuemei Qin
OBJECTIVES: Selective serotonin reuptake inhibitors (SSRIs) are the first-line anti-depressants. Unfortunately, about 30 % depressed patients do not effectively respond to SSRIs. It is still unclear that the gastrointestinal characteristics of responders and non-responders, and the differences. METHODS: Herein, we characterized gut microbiome and metabolome of depressed rats with differential responses to Paroxetine (PX) by 16S rRNA sequencing and 1 H NMR-based metabolomics, respectively...
February 10, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38331868/blockade-of-c5ar1-resets-m1-via-gut-microbiota-mediated-pfkm-stabilization-in-a-tlr5-dependent-manner
#13
JOURNAL ARTICLE
Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji, Xueqin Li, Na Sun, Rongqing Li, Yuzhang Wu, Kuiyang Zheng, Yuchen Pan, Tingting Zhao, Jing Yang
Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether and how the gut flora is involved in C5aR1 inhibition-mediated TAMs remains unclear. Therefore, in this study, genetic deletion of C5ar1 or pharmacological inhibition of C5aR1 with anti-C5aR1 Ab or PMX-53 in the presence or absence of deletion Abs were utilized to verify if and how C5aR1 inhibition regulated TAMs polarization via affecting gut microbiota composition...
February 8, 2024: Cell Death & Disease
https://read.qxmd.com/read/38326718/effects-of-bisphenol-a-and-its-substitute-bisphenol-f-on-the-gut-microbiota-in-mice
#14
JOURNAL ARTICLE
Li Ying Meng, Wen Fu Tao, Jing Li, Min Zhu, De Bin Zhong, Jing Zhou, Xue Qin, Rong Guo Wei
OBJECTIVE: The aim of this study was to assess the impact of bisphenol A (BPA) and its substitute, bisphenol F (BPF), on the colonic fecal community structure and function of mice. METHODS: We exposed 6-8-week-old male C57BL/6 mice to 5 mg/(kg∙day) and 50 μg/(kg∙day) of BPA or BPF for 14 days. Fecal samples from the colon were analyzed using 16S rRNA sequencing. RESULTS: Gut microbiome community richness and diversity, species composition, and function were significantly altered in mice exposed to BPA or BPF...
January 20, 2024: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/38305839/serum-metabolome-and-gut-microbiome-alterations-are-associated-with-low-handgrip-strength-in-older-adults
#15
JOURNAL ARTICLE
Yan Guo, Qin Wang, Yifan Lv, Fan Xia, Xin Chen, Yan Mao, Xiaodong Wang, Guoxian Ding, Jing Yu
Handgrip strength (HGS), which represents global muscle strength, is a powerful indicator of disability and mortality in older adults; it is also used for the diagnosis of possible- or probable- sarcopenia and physical frailty. This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples...
February 1, 2024: Aging
https://read.qxmd.com/read/38286081/response-of-salivary-microbiome-to-temporal-environmental-and-surface-characteristics-under-in-vitro-exposure
#16
JOURNAL ARTICLE
Litao Huang, Xiaomin Liang, Guichao Xiao, Jieyu Du, Linying Ye, Qin Su, Chao Liu, Ling Chen
The microbiome of saliva stains deposited at crime scenes and in everyday settings is valuable for forensic investigations and environmental ecology. However, the dynamics and applications of microbial communities in these saliva stains have not been fully explored. In this study, we analyzed saliva samples that were exposed to indoor conditions for up to 1 year and to different carriers (cotton, sterile absorbent cotton swab, woolen, dacron) in both indoor and outdoor environments for 1 month using high-throughput sequencing...
January 24, 2024: Forensic Science International. Genetics
https://read.qxmd.com/read/38268569/the-role-of-type-2-diabetes-mellitus-related-risk-factors-and-drugs-in-hepatocellular-carcinoma
#17
REVIEW
Yuhua Mai, Liheng Meng, Ganlu Deng, Yingfen Qin
With changes in modern lifestyles, type 2 diabetes mellitus (T2DM) has become a global epidemic metabolic disease, and hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. T2DM is a complex metabolic disorder and has been considered an independent risk factor for HCC. Growing evidence supports that T2DM-related risk factors facilitate hepatocarcinogenesis via abundant mechanisms. With the wide implementation of microbiomics, transcriptomics, and immunotherapy, the understanding of the complex mechanisms of intestinal flora and immune cell subsets have advanced tremendously in T2DM-related HCC, uncovering new findings in T2DM-related HCC patients...
2024: Journal of Hepatocellular Carcinoma
https://read.qxmd.com/read/38265817/microbiome-dysbiosis-by-antibiotics-protects-cartilage-degradation-in-oaop-mice
#18
JOURNAL ARTICLE
Qin Yin, Jun Gu, Pengju Ren, Zhiqiang Guan, Yongxiang Wang, Ruijun Bai, Yu Liu
The role of this study was to evaluate the impact of gut microbiota depletion on the progression of osteoarthritis (OA) and osteoporosis (OP). We conducted an experimental mouse model of OA and OP over an 8-week period. The model involved destabilization of the medial meniscus (DMM) and bilateral ovariectomy (OVX). To deplete the gut microbiota, we administered a course of antibiotics for 8 weeks. The severity of OA was assessed through micro-CT scanning, X-rays, and immunohistochemical staining. Microbiome analysis was performed using PCR of 16S DNA on fecal samples, and the levels of serum lipopolysaccharide, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), osteocalcin, and estrogen were measured using enzyme-linked immunosorbent assay (ELISA)...
January 1, 2024: Journal of Endocrinology
https://read.qxmd.com/read/38259095/a-bioinformatics-tool-for-identifying-intratumoral-microbes-from-the-orien-dataset
#19
JOURNAL ARTICLE
Cankun Wang, Anjun Ma, Yingjie Li, Megan E McNutt, Shiqi Zhang, Jiangjiang Zhu, Rebecca Hoyd, Caroline E Wheeler, Lary A Robinson, Carlos H F Chan, Yousef Zakharia, Rebecca D Dodd, Cornelia M Ulrich, Sheetal Hardikar, Michelle L Churchman, Ahmad A Tarhini, Eric A Singer, Alexandra P Ikeguchi, Martin D McCarter, Nicholas Denko, Gabriel Tinoco, Marium Husain, Ning Jin, Afaf E G Osman, Islam Eljilany, Aik Choon Tan, Samuel S Coleman, Louis Denko, Gregory Riedlinger, Bryan P Schneider, Daniel Spakowicz, Qin Ma
Evidence supports significant interactions among microbes, immune cells, and tumor cells in at least 10-20% of human cancers, emphasizing the importance of further investigating these complex relationships. However, the implications and significance of tumor-related microbes remain largely unknown. Studies have demonstrated the critical roles of host microbes in cancer prevention and treatment responses. Understanding interactions between host microbes and cancer can drive cancer diagnosis and microbial therapeutics (bugs as drugs)...
January 23, 2024: Cancer Res Commun
https://read.qxmd.com/read/38254686/exploring-plga-oh-cath30-microspheres-for-oral-therapy-of-escherichia-coli-induced-enteritis
#20
JOURNAL ARTICLE
Xiaoqian Jiao, Bin Liu, Xufeng Dong, Shubai Wang, Xiulei Cai, Hongliang Zhang, Zhihua Qin
Antibiotic therapy effectively addresses Escherichia coli -induced enteric diseases, but its excessive utilization results in microbial imbalance and heightened resistance. This study evaluates the therapeutic efficacy of orally administered poly (lactic-co-glycolic acid) (PLGA)-loaded antimicrobial peptide OH-CATH30 microspheres in murine bacterial enteritis. Mice were categorized into the healthy control group (CG), untreated model group (MG), OH-CATH30 treatment group (OC), PLGA-OH-CATH30 treatment group (POC), and gentamicin sulfate treatment group (GS)...
January 10, 2024: Biomolecules
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