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Synovial sarcoma

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https://www.readbyqxmd.com/read/28293005/-primary-pulmonary-synovial-sarcoma-confirmed-by-demonstration-of-syt-ssx-fusion-gene-translocation-by-fluorescence-in-situ-hybridization
#1
Motoaki Yasukawa, Tomoko Uchiyama, Takeshi Kawaguchi, Norikazu Kawai, Chiho Ohbayashi, Takashi Tojo
A 58-year-old man was referred to our hospital due to a mass shadow noted on a chest X-ray. Chest computed tomography showed a 3 cm nodule in the left lung. Thoracoscopic left upper lobectomy was performed to remove the lesion, and the postoperative diagnosis was primary pulmonary synovial sarcoma according to the histology and SYT-SSX gene analysis.
March 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28280643/synovial-sarcoma-of-the-larynx-report-of-a-case-and-review-of-literature
#2
Geetha Narayanan, Anto Baby, Thara Somanathan, Sreedevi Konoth
Sarcomas account for less than 1% of malignant neoplasms arising in the head and neck in adults. Laryngeal synovial sarcoma is an extremely rare form of laryngeal malignancy with less than 20 cases reported in the literature. We report the case of a 48-year-old man with synovial sarcoma of the larynx. He underwent excision of the tumor followed by radiation. He is alive in remission at 36 months. The literature on synovial sarcoma of the larynx is reviewed.
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28271871/soft-tissue-sarcomas-in-adolescents-and-young-adults-a-comparison-with-their-paediatric-and-adult-counterparts
#3
REVIEW
Winette T A van der Graaf, Daniel Orbach, Ian R Judson, Andrea Ferrari
Survival outcomes for adolescent and young adult patients with soft tissue sarcomas lag behind those of children diagnosed with histologically similar tumours. To help understand these differences in outcomes, we discuss the following issues with regard to the management of these patients with soft tissue sarcomas: delays in diagnosis, trial availability and participation, aspects of the organisation of care (with an emphasis on age-specific needs), national centralisation of sarcoma care, international consortia, and factors related to tumour biology...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28259825/soft-tissue-neoplasms-causing-apparent-venous-thoracic-outlet-syndrome
#4
Aleem K Mirza, Ian J Barrett, Animesh Rathore, Bassem T Elhassan, Peter S Rose, Thomas Shives, Thomas C Bower
Venous thoracic outlet syndrome (vTOS) usually results from compression of the subclavian vein classically as a result of narrowing of the costoclavicular space. We report two rare cases of soft tissue neoplasms resulting in apparent vTOS. The first case is a 46-year old female with a two-year history intermittent unilateral shoulder pain, who was initially diagnosed with intervertebral disk herniation. Cervical fusion was performed, however her symptoms progressed and she additionally developed paresthesias and venous congestion...
March 1, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28249647/a-clinicopathologic-study-on-ss18-fusion-positive-head-and-neck-synovial-sarcomas
#5
Adepitan A Owosho, Cherry L Estilo, Evan B Rosen, SaeHee K Yom, Joseph M Huryn, Cristina R Antonescu
OBJECTIVE: To determine clinicopathologic factors on survival in patients with head and neck synovial sarcoma. PATIENTS AND METHODS: We retrospectively identified patients with molecularly confirmed synovial sarcomas of the head and neck (SS-HN), either by the presence of SS18-SSX fusion transcript by RT-PCR or SS18 gene rearrangement by FISH, who were managed at our institution over a 20-year period (1996-2015). Kaplan-Meier survival analysis and log-rank test were performed to evaluate variables related to disease specific survival (DSS)...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28248726/pax8-positive-biphasic-synovial-sarcoma-expressing-hormonal-receptors
#6
Leonardo Lordello, Martin E Bur, Esther Oliva, Jochen K Lennerz
PAX8, estrogen receptor-α (ERα) and progesterone receptor (PR) are markers usually expressed in neoplasms of müllerian origin. We report a subdiaphragmal mass in a 41-year-old woman corresponding to a malignant biphasic tumor with nests of epithelial-like cells forming variably sized cyst-like spaces alternating with spindle cells forming intersecting fascicles. The later were juxtaposed to coalescent densely cellular nodules of spindle cells with appreciable cytologic atypia and mitotic counts up to 30/10 high-power fields...
February 28, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28248724/tle-1-positive-angiomatoid-fibrous-histiocytoma-mimicking-synovial-sarcoma
#7
Daniel J Zaccarini, Rana Naous, Yesha Sheth, Ola El-Zammar, Gustavo de la Roza, Christopher M Curtiss
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor most commonly seen in young adults and children. We report a case with morphology and immunohistochemistry supporting the diagnosis of synovial sarcoma. On core biopsy, the tumor had spindle cell and epithelioid morphology with a myxoid background. Staining for transducin-like enhancer of split 1 and CD99 were positive; however, subsequent fluorescence in situ hybridization for SYT (SS18, nBAF chromatin remodeling complex subunit) break apart returned negative...
February 28, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28214655/identification-of-microrna-biomarkers-for-response-of-advanced-soft-tissue-sarcomas-to-eribulin-translational-results-of-the-eortc-62052-trial
#8
Erik A C Wiemer, Agnieszka Wozniak, Herman Burger, Marcel Smid, Giuseppe Floris, Axelle Nzokirantevye, Raf Sciot, Stefan Sleijfer, Patrick Schöffski
BACKGROUND: Recent phase II and III clinical trials demonstrated anti-tumour activity of eribulin, a tubulin-interacting cytotoxic agent, in patients with metastatic soft tissue sarcoma (STS). In this exploratory study, we aimed to identify putative microRNA biomarkers that associate with eribulin sensitivity or resistance in STS. MATERIALS AND METHODS: Archival tumour tissue from primary tumours or metastatic lesions was collected prior to eribulin treatment, from 65 consenting patients involved in the EORTC trial 62052...
February 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28205183/large-primary-pleural-synovial-sarcoma-with-severe-dyspnea-a-case-report
#9
Minoru Yamaki, Shuji Yonehara, Toshio Noriyuki
BACKGROUND: Synovial sarcoma is a malignant neoplasm of soft tissues. It occurs mainly in the extremities and is closely related to tendons, tendon sheaths, and bursal structures. Primary synovial sarcoma of the pleura and lungs is extremely rare. CASE PRESENTATION: We present the case of a 62-year-old man with a large synovial sarcoma of the left pleura. He presented with general fatigue and severe dyspnea. Chest computed tomography (CT) revealed a 20-cm tumor in the left thoracic cavity...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28195904/pericardial-synovial-sarcoma-followed-up-with-contrast-enhanced-pet-ct
#10
Avani S Jain, Shelley Simon, Indirani Muthukrishnan, Aashish Gambhir, Sushma Patil
Pericardial synovial sarcoma is an extremely rare tumor, and a challenging diagnosis due to nonspecific diverse presentation requiring a very strong clinical acumen along with an aggressive multimodal approach. Histopathological confirmation remains the gold standard. The optimal management is unclear because of very few cases reported in literature. Herein, we describe the findings on contrast-enhanced FDG PET-CT facilitating the staging, lesion characterization, and timely response assessment to chemotherapy...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28191313/metastatic-biomarkers-in-synovial-sarcoma
#11
REVIEW
Rosalia de Necochea-Campion, Lee M Zuckerman, Hamid R Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi
Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of the fusion is unknown...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28183682/synovial-sarcoma-of-the-hard-palate-the-third-case-in-the-medical-literature
#12
Aseel Doubi, Motaz Doubi, Nabil Alzaher, Asma Tulbah
Synovial sarcoma is a high-grade soft tissue sarcoma that rarely arises in the head and neck region. It affects the parapharyngeal space and the hypopharynx most commonly and it has different presentations based on the affected site. In extremely rare occasions, it involves the hard palate such as in our case where a 24-year-old female patient presented with a mass lesion involving the left hard palate, which was identified clinically and by imaging studies. The histopathological assessment confirmed that it was a monophasic synovial sarcoma which was also confirmed with further molecular studies...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28178719/endometriosis-mimicking-soft-tissue-neoplasms-a-potential-diagnostic-pitfall
#13
Yi Ding, Julie Gibbs, Ge Xiong, Shigong Guo, Shailaja Raj, Marilyn M Bui
Endometriosis is a common gynecological disorder most often involving the pelvic region. Although it is rare, endometriosis occurring outside of the peritoneal cavity most commonly occurs within scars of the abdominal wall, but it has been reported in the lungs, pleura, kidneys, brain, and the extremities. Herein, we present 2 cases of endometriosis, including 1 case of endometriosis of the wrist that clinically mimicked a soft-tissue neoplasm and 1 case of right-groin endometriosis mimicking synovial sarcoma during the initial pathological interpretation of findings on fine needle aspiration...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28168073/two-cases-of-ectopic-hamartomatous-thymoma-masquerading-as-sarcoma
#14
Takahito Kondo, Yukiko Sato, Hiroko Tanaka, Toru Sasaki, Kazuyoshi Kawabata, Hiroki Mitani, Hiroyuki Yonekawa, Hirofumi Fukushima, Wataru Shimbashi
Ectopic hamartomatous thymoma (EHT) is an extremely rare benign tumor. EHTs are difficult to differentiate from sarcomas, especially synovial sarcomas. We encountered two cases of EHT that were referred from other hospitals because sarcoma was suspected. In these cases, fusion gene detection via polymerase chain reaction or fluorescence in situ hybridization was useful for differentiating EHT from synovial sarcoma. EHT requires accurate diagnosis before surgery to avoid excessive treatment. Both tumor location and the presence of fat inside the tumor are important imaging findings for EHT, and confirmation of spindle cells, epithelial cells, and mature adipose cells in the tumor is an important pathological finding...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28134577/primary-intraprostatic-synovial-sarcoma
#15
REVIEW
Andrea M Olofson, Konstantinos Linos
Primary intraprostatic synovial sarcoma is a rare presentation of an otherwise well-studied disease, and it is one of the few primary sarcomas to occur in the prostate. Ancillary diagnostic techniques including immunohistochemistry and molecular genetics are useful to establish a definitive diagnosis. Despite its unorthodox location, it shares histologic and molecular genetic characteristics with tumors found elsewhere in the body. Most notably, the chromosomal translocation t(X;18)(p11;q11) encodes a chimeric transcription-activating protein, SS18-SSX, which has been identified as the primary driver mutation...
February 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28109176/oncogenic-roles-of-smarcb1-ini1-and-its-deficient-tumors
#16
Kenichi Kohashi, Yoshinao Oda
SMARCB1/INI1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. Interactions have been demonstrated between SMARCB1/INI1 and key proteins in various pathways related to tumor proliferation and progression: the p16-RB pathway, WNT signaling pathway, sonic hedgehog signaling pathway and Polycomb pathway. Initially, no detectable SMARCB1/INI1 protein expression was found in malignant rhabdoid tumor cells, whereas all other kinds of tumor cells and non-tumorous tissue showed SMARCB1/INI1 protein expression...
January 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#17
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28101733/3d-absorbed-dose-distribution-estimated-by-monte-carlo-simulation-in-radionuclide-therapy-with-a-monoclonal-antibody-targeting-synovial-sarcoma
#18
David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza, Anne-Laure Giraudet
BACKROUND: Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant (111)In-OTSA101 tumor uptake and favorable biodistribution, patient was randomly treated with 370/1110 MBq (90)Y-OTSA101. Monte Carlo-based 3D dosimetry integrating time-activity curves in VOI was performed on (111)In-OTSA101 repeated SPECT/CT. Estimated absorbed doses (AD) in normal tissues were compared to biological side effects and to the admitted maximal tolerated absorbed dose (MTD) in normal organs...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28087966/gastric-ulcer-that-turned-out-to-be-metastasis-of-a-synovial-sarcoma-a-case-report-and-literature-review
#19
T Samuel, S Norly, P Ros'aini
Primary gastrointestinal synovial sarcoma or its metastases to the gastrointestinal tract is rare. Here we present a case of 56-year-old gentleman with left thigh synovial sarcoma and gastric metastases along with the literature review.
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28056288/-clinical-application-of-125-i-radioactive-seeds-brachytherapy-in-the-treatment-of-the-pediatric-soft-tissue-sarcoma-in-head-and-neck
#20
D Zhao, L Zheng, X M Lü, M W Huang, Y Shi, X L Ma, J Yan, J G Zhang
Objective: To investigate the clinical application and preliminary results of (125)I radioactive seeds brachytherapy in the comprehensive treatment of the pediatric soft tissue sarcoma in head and neck. Methods: A total of 24 pediatric patients with soft tissue sarcoma in head and neck were treated at Peking University School of Stomatology from April 2012 to July 2015. The data was collected and analyzed through statistical methods, which included the pathological type, gender, age, tumor location, volume, treatment and the clinical results after the application of (125)I radioactive seeds brachytherapy...
January 3, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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