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https://www.readbyqxmd.com/read/28340426/porcine-parvovirus-induces-activation-of-nf-%C3%AE%C2%BAb-signaling-pathways-in-pk-15-cells-mediated-by-toll-like-receptors
#1
Liyan Cao, Jianfei Chen, Yanwu Wei, Hongyan Shi, Xin Zhang, Jing Yuan, Da Shi, Jianbo Liu, Xiangdong Zhu, Xin Wang, Shangjin Cui, Li Feng
Porcine parvovirus (PPV) is a pathogenic factor that primarily induces severe reproductive failure of pregnant swine, which results in extensive losses to the swine industry worldwide. In this study, a potential mechanism of PPV-induced activation of the nuclear transcription factor-kappaB (NF-κB) by infection in porcine kidney cells (PK-15) was elucidated for the first time. The subcellular localization of p65 analyzed by immunofluorescence assay (IFA) showed that PPV infection induced p65 translocation from the cytoplasm to the nucleus...
March 21, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28333795/diagnostic-tests-for-evaluation-of-stillbirth-results-from-the-stillbirth-collaborative-research-network
#2
Jessica M Page, Lauren Christiansen-Lindquist, Vanessa Thorsten, Corette B Parker, Uma M Reddy, Donald J Dudley, George R Saade, Donald Coustan, Carol J Rowland Hogue, Deborah Conway, Radek Bukowski, Halit Pinar, Cara C Heuser, Karen J Gibbins, Robert L Goldenberg, Robert M Silver
OBJECTIVE: To estimate the usefulness of each diagnostic test in the work-up for potential causes of stillbirth. METHODS: A secondary analysis of 512 stillbirths enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based study of stillbirth in the United States. Participants underwent standardized evaluations that included maternal interview, medical record abstraction, biospecimen collection, fetal autopsy, and placental pathology...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28331084/structural-insights-into-emerging-pediatric-pathogens-human-bocaparvoviruses
#3
Mario Mietzsch, Shweta Kailasan, Jamie Garrison, Maria Ilyas, Paul Chipman, Kalle Kantola, Mandy E Janssen, John Spear, Duncan Sousa, Robert McKenna, Kevin Brown, Maria Söderlund-Venermo, Timothy Baker, Mavis Agbandje-McKenna
Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28328962/the-blood-dna-virome-in-8-000-humans
#4
Ahmed Moustafa, Chao Xie, Ewen Kirkness, William Biggs, Emily Wong, Yaron Turpaz, Kenneth Bloom, Eric Delwart, Karen E Nelson, J Craig Venter, Amalio Telenti
The characterization of the blood virome is important for the safety of blood-derived transfusion products, and for the identification of emerging pathogens. We explored non-human sequence data from whole-genome sequencing of blood from 8,240 individuals, none of whom were ascertained for any infectious disease. Viral sequences were extracted from the pool of sequence reads that did not map to the human reference genome. Analyses sifted through close to 1 Petabyte of sequence data and performed 0.5 trillion similarity searches...
March 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28328889/sanitized-corncob-bedding-destruction-of-murine-parvovirus
#5
Rigoberto Sanchez, David Johnson, Matthew C Terzi, Michelle Izuka, E Douglas Allen, Michael O'Donnoghue, Aubrey Mendonca, Kelly Yachera, Louis DeTolla
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28301545/implication-of-the-intestinal-microbiome-as-a-potential-surrogate-marker-of-immune-responsiveness-to-experimental-therapies-in-autoimmune-diabetes
#6
James C Needell, Charles A Dinarello, Diana Ir, Charles E Robertson, Sarah M Ryan, Miranda E Kroehl, Daniel N Frank, Danny Zipris
Type 1 diabetes (T1D) is an autoimmune proinflammatory disease with no effective intervention. A major obstacle in developing new immunotherapies for T1D is the lack of means for monitoring immune responsiveness to experimental therapies. The LEW1.WR1 rat develops autoimmunity following infection with the parvovirus Kilham rat virus (KRV) via mechanisms linked with activation of proinflammatory pathways and alterations in the gut bacterial composition. We used this animal to test the hypothesis that intervention with agents that block innate immunity and diabetes is associated with a shift in the gut microbiota...
2017: PloS One
https://www.readbyqxmd.com/read/28288327/parvovirus-b19-infection-modulates-the-levels-of-cytokines-in-the-plasma-of-rheumatoid-arthritis-patients
#7
Milda Naciute, Diana Mieliauskaite, Rita Rugiene, Gabriele Maciunaite, Mykolas Mauricas, Modra Murovska, Irute Girkontaite
BACKGROUND: Parvovirus B19 (B19V) infection is associated with various autoimmune diseases. We investigated the levels of pro-inflammatory (IFNᵧ, TNFα, IL-2, IL-12) and anti-inflammatory (IL-4, IL-10) cytokines in the plasma of B19V DNA positive (B19(+)) and negative (B19(-)) rheumatoid arthritis (RA) patients in comparison with the control group (healthy persons). METHODS: Blood samples were collected from 118 patients with RA and 49 healthy voluntaries. B19V sequence was determined in whole blood and cell-free plasma DNA by nested PCR...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28284623/prevalence-and-molecular-epidemiology-of-canine-parvovirus-2-in-diarrheic-dogs-in-colombia-south-america-a-possible-new-cpv-2a-is-emerging
#8
Yeison Duque-García, Manuela Echeverri-Zuluaga, Juanita Trejos-Suarez, Julian Ruiz-Saenz
Since its identification in 1978, Canine parvovirus type 2 (CPV-2) has been considered a pathogen of great importance in the canine population because it causes severe enteritis with high mortality rates in pups. CPV-2 is a virus belonging to the family Parvoviridae. Currently, there are three described antigenic variants (CPV-2a, CPV-2b, and CPV-2c). CPV-2c is an emerging virus that is seen as a global health hazard. The objective of this work was to confirm the presence of CPV-2 in dogs with acute gastroenteritis compatible with parvovirus and to molecularly characterize the antigenic variants circulating in two regions of Colombia...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28284244/chapparvoviruses-occur-in-at-least-three-vertebrate-classes-and-have-a-broad-biogeographic-distribution
#9
William Marciel de Souza, Marilia Farignoli Romeiro, Marcílio Jorge Fumagalli, Sejal Modha, Jansen de Araujo, Luzia Helena Queiroz, Edison Luiz Durigon, Luiz Tadeu Moraes Figueiredo, Pablo Ramiro Murcia, Robert James Gifford
Chapparvoviruses are a highly divergent group of parvoviruses (family Parvoviridae) that have recently been identified via metagenomic sampling of animal faeces. Here, we report the sequences of six novel chapparvoviruses identified through both metagenomic sampling of bat tissues and in silico screening of published vertebrate genome assemblies. The novel chapparvoviruses share several distinctive genomic features and group together as a robustly supported monophyletic clade in phylogenetic trees. Our data indicate that chapparvoviruses have a broad host range in vertebrates and a global distribution...
February 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28283075/canine-parvovirus-post-vaccination-shedding-interference-with-diagnostic-assays-and-correlation-with-host-immune-status
#10
EDITORIAL
Nicola Decaro, Canio Buonavoglia
No abstract text is available yet for this article.
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28277368/diagnostic-tests-for-evaluation-of-stillbirth-stillbirth-collaborative-research-network
#11
Jessica M Page, Lauren Christiansen-Lindquist, Vanessa Thorsten, Corette B Parker, Uma M Reddy, Donald J Dudley, George R Saade, Donald Coustan, Carol J Rowland Hogue, Deborah Conway, Radek Bukowski, Halit Pinar, Cara C Heuser, Karen J Gibbins, Robert L Goldenberg, Robert M Silver
OBJECTIVE: To estimate the usefulness of each diagnostic test in the work-up for potential causes of stillbirth. METHODS: A secondary analysis of 512 stillbirths enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based study of stillbirth in the United States. Participants underwent standardized evaluations that included maternal interview, medical record abstraction, biospecimen collection, fetal autopsy, and placental pathology...
March 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28264028/parvovirus-b19-ns1-protein-induces-cell-cycle-arrest-at-g2-phase-by-activating-the-atr-cdc25c-cdk1-pathway
#12
Peng Xu, Zhe Zhou, Min Xiong, Wei Zou, Xuefeng Deng, Safder S Ganaie, Steve Kleiboeker, Jianxin Peng, Kaiyu Liu, Shengqi Wang, Shui Qing Ye, Jianming Qiu
Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest at G2-phase; however, a putative C-terminal transactivation domain (TAD2) within NS1 is responsible for G2-phase arrest. To fully understand the mechanism underlying B19V NS1-induced G2-phase arrest, we established two doxycycline-inducible B19V-permissive UT7/Epo-S1 cell lines that express NS1 or NS1mTAD2, and examined the function of the TAD2 domain during G2-phase arrest...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28263841/the-formation-and-modification-of-chromatin-like-structure-of-human-parvovirus-b19-regulate-viral-genome-replication-and-rna-processing
#13
Huanzhou Xu, Sujuan Hao, Junmei Zhang, Zhen Chen, Hanzhong Wang, Wuxiang Guan
B19 virus (B19V) is a single stranded virus in the genus of Erythroparvovirus in the family of Parvoviridae. One of the limiting steps of B19V infection is the replication of viral genome which affected the alternative processing of its RNA. Minute virus of mice (MVM) and adeno-associated virus (AAV) has been reported to form chromatin-like structure within hours after infection of cells. However, the role of chromatin-like structure is unclear. In the present study, we found that B19V formed chromatin-like structure after 12h when B19V infectious clone was co-transfected with pHelper plasmid to HEK293T cells...
March 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28254505/mt-pcr-panel-detection-of-canine-parvovirus-cpv-2-vaccine-and-wild-type-cpv-2-can-be-difficult-to-differentiate-in-canine-diagnostic-fecal-samples
#14
Maira N Meggiolaro, Anna Ly, Benjamin Rysnik-Steck, Carolina Silva, Joshua Zhang, Damien P Higgins, Gary Muscatello, Jacqueline M Norris, Mark Krockenberger, Jan Šlapeta
Canine parvovirus (CPV-2) remains an important cause of devastating enteritis in young dogs. It can be successfully prevented with live attenuated CPV-2 vaccines when given at the appropriate age and in the absence of maternal antibody interference. Rapid diagnosis of parvoviral enteritis in young dogs is essential to ensuring suitable barrier nursing protocols within veterinary hospitals. The current diagnostic trend is to use multiplexed PCR panels to detect an array of pathogens commonly responsible for diarrhea in dogs...
February 27, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28242782/role-of-canine-circovirus-in-dogs-with-acute-haemorrhagic-diarrhoea
#15
A Anderson, K Hartmann, C M Leutenegger, A L Proksch, R S Mueller, S Unterer
Canine circovirus (CanineCV) has been detected in some dogs with severe haemorrhagic diarrhoea, but its pathogenic role is unclear. This study evaluated a suspected association between the presence of CanineCV and acute haemorrhagic diarrhoea syndrome (AHDS) in dogs. The prevalence of CanineCV in dogs with AHDS was compared with that in healthy dogs and those infected with canine parvovirus (CPV). Additionally, time to recovery and mortality rate were compared between CanineCV-positive and CanineCV-negative dogs...
February 27, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28241813/anaemia-in-hospitalised-preschool-children-from-a-rural-area-in-mozambique-a-case-control-study-in-search-for-aetiological-agents
#16
Cinta Moraleda, Ruth Aguilar, Llorenç Quintó, Tacilta Nhampossa, Montserrat Renom, Augusto Nhabomba, Sozinho Acácio, John J Aponte, Delino Nhalungo, Ariel H Achtman, Louis Schofield, Helder Martins, Eusebio Macete, Pedro L Alonso, Clara Menéndez
BACKGROUND: Young children bear the world's highest prevalence of anaemia, the majority of which is of multifactorial aetiology, which in turn hampers its successful prevention. Even moderate degrees of anaemia are associated with increased mortality and morbidity. Despite this evidence, there is a lack of effective preventive programs and absence of consensus in the safety of iron supplementation in malaria areas, which reflects the poor understanding of the contribution of different aetiologies to anaemia...
February 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28238913/antiviral-activity-of-phosphorylated-radix-cyathulae-officinalis-polysaccharide-against-canine-parvovirus-in-vitro
#17
Haibo Feng, Jing Fan, Shiping Yang, Xuelian Zhao, Xiao Yi
Phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) was prepared according to three-factors, ratio of STMP (%) and STPP (%), reaction time and reaction temperature, and three level L9(3(4)) orthogonal design. The antiviral activity of nine pRCPS (pRCPS1-9) was systematically evaluated by three methods pre-adding mode, mixed mode, and post-adding mode. Cellular activity was tested by the CCK-8 assay. The results showed that the optimal modification conditions were the ratio of STMP (%) and STPP (%) 1:4, reaction time 2h and reaction temperature 65°C...
February 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28237237/expanding-veterinary-biosurveillance-in-washington-dc-the-creation-and-utilization-of-an-electronic-based-online-veterinary-surveillance-system
#18
Andrew Hennenfent, Vito DelVento, John Davies-Cole, Fern Johnson-Clarke
OBJECTIVES: To enhance the early detection of emerging infectious diseases and bioterrorism events using companion animal-based surveillance. METHODS: Washington, DC, small animal veterinary facilities (n=17) were surveyed to determine interest in conducting infectious disease surveillance. Using these results, an electronic-based online reporting system was developed and launched in August 2015 to monitor rates of canine influenza, canine leptospirosis, antibiotic resistant infections, canine parvovirus, and syndromic disease trends...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28236170/pathogen-safety-of-a-new-intravenous-immune-globulin-10-liquid
#19
Kai Uwe Radomski, Georg Lattner, Torben Schmidt, Jürgen Römisch
BACKGROUND: The manufacturing process of a new intravenous immune globulin (IVIG) 10% liquid product incorporates two dedicated pathogen safety steps: solvent/detergent (S/D) treatment and nanofiltration (20 nm). Ion-exchange chromatography (IEC) during protein purification also contributes to pathogen safety. The ability of these three process steps to inactivate/remove viruses and prions was evaluated. OBJECTIVES: The objective of this study was to evaluate the virus and prion safety of the new IVIG 10% liquid...
February 24, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28229163/-prevalence-of-dog-circovirus-in-healthy-and-diarrhoeic-dogs
#20
Michaela Gentil, Achim D Gruber, Elisabeth Müller
OBJECTIVE: In 2012, a Dog circovirus (DogCV) was discovered in the USA, which was followed by further descriptions of the virus in the USA, Italy and Germany. The present study is the first to examine the prevalence of DogCV in faeces of dogs from Germany and other European countries. MATERIAL AND METHODS: Faecal samples from 184 dogs with diarrhoea and from 82 clinically healthy dogs (control group) were analysed for the presence of DogCV by PCR. Furthermore, the detection of parvovirus, coronavirus, Giardia and Cryptosporidium was performed in all samples...
February 23, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
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