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https://www.readbyqxmd.com/read/29026475/human-parvovirus-b19-in-children-with-sickle-cell-disease-poking-the-spleen
#1
Ashraf Abdellah Saad, Ismail Beshlawi, Abdul Hakim Al-Rawas, Mathew Zachariah, Hanan Fawzy Nazir, Yasser Wali
Parvovirus is a known culprit of transient red cell aplasia (TRCA) in children with sickle cell disease (SCD). Few reports have previously described the association between the virus and acute splenic sequestration crisis (ASSC) in the same patient. Here, we are shedding light on such a potentially serious combination by reporting two cases of siblings with SCD complicated with concurrent ASSC and TRCA and presenting a review of the relevant literature.
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29022179/first-identification-of-porcine-parvovirus-7-in-china
#2
Xiulin Xing, Han Zhou, Ling Tong, Yao Chen, Yankuo Sun, Heng Wang, Guihong Zhang
Porcine parvovirus (PPV) are small, non-enveloped and single-stranded DNA viruses, taxonomically classifiable within the family Parvoviridae. Seven PPV genotypes (PPV1 to PPV7) have been identified to date. PPV7, the most recently discovered PPV genotype, was first reported in US pigs in 2016. To explore PPV7 status in Chinese pig populations a total of 64 serum samples collected from two commercial farms in Guangdong province in 2014 were analyzed. PPV7 DNA was detected in 32.8% (21/64) of tested samples. On the porcine circovirus type 2 (PCV2) positive farm, the prevalence rate of PPV7 was 65...
October 11, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29021400/human-parvovirus-infection-of-human-airway-epithelia-induces-pyroptotic-cell-death-via-inhibiting-apoptosis
#3
Xuefeng Deng, Wei Zou, Min Xiong, Zekun Wang, John F Engelhardt, Shui Qing Ye, Ziying Yan, Jianming Qiu
Human bocavirus 1 (HBoV1) is a human parvovirus that causes acute respiratory tract infections in young children. In this study, we confirmed that, when polarized/well-differentiated human airway epithelia are infected with HBoV1 in vitro, they develop damage characterized by barrier function disruption and cell hypotrophy. Cell death mechanism analyses indicated that the infection induced pyroptotic cell death characterized by caspase-1 activation. Unlike infections with other parvoviruses, HBoV1 infection did not activate the apoptotic or necroptotic cell death pathway...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29020199/viral-surveillance-in-serum-samples-from-patients-with-acute-liver-failure-by-metagenomic-next-generation-sequencing
#4
Sneha Somasekar, Deanna Lee, Jody Rule, Samia N Naccache, Mars Stone, Michael P Busch, Corron Sanders, William M Lee, Charles Y Chiu
Background: Twelve percent of all acute liver failure (ALF) cases are of unknown origin, often termed indeterminate. A previously unrecognized hepatotropic virus has been suspected as a potential etiologic agent. Methods: We compared the performance of metagenomic next-generation sequencing (mNGS) with confirmatory nucleic acid testing (NAT) to routine clinical diagnostic testing in detection of known or novel viruses associated with ALF. Serum samples from 204 adult ALF patients collected from 1998 to 2010 as part of a nationwide registry were analyzed...
July 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28992849/severe-myoglobinuric-acute-kidney-injury-in%C3%A2-a%C3%A2-kidney-recipient-rapid-recovery-after-hemodialysis-with-the-super-high-flux-membrane-theralite%C3%A2-%C3%A2
#5
Ahmed Goubella, Fabrice Gankam-Kengne, Thomas Baudoux, David Fagnoul, Cécile Husson, Marie-Luce Delforge, Nilufer Broeders, Joëlle Nortier
Myoglobinuric acute kidney injury (AKI) is a severe condition requiring early therapeutic strategies. Early recognition and treatment are crucial to reduce morbidity and mortality rate. Here, we report a kidney recipient with severe rhabdomyolysis and AKI secondary to parvovirus B19 infection. Initiation of hemodialysis with the super high-flux filter Theralite® (Gambro, cut-off 45 kDa, 2.1 m2) resulted in the clearance of myoglobin from 61 to 71% after 3 hours. Elimination rates of IL-6 and β2-microglobulin were ~ 30 - 64% and 55 - 71% after 3 hours, respectively...
October 10, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28984228/substitutions-at-residues-300-and-389-of-the-vp2-capsid-protein-serve-as-the-minimal-determinant-of-attenuation-for-canine-parvovirus-vaccine-strain-9985-46
#6
Go Sehata, Hiroaki Sato, Morimasa Yamanaka, Takuo Takahashi, Risa Kainuma, Tatsuhiko Igarashi, Sho Oshima, Taichi Noro, Eiji Oishi
Identifying molecular determinants of virulence attenuation in live attenuated canine parvovirus (CPV) vaccines is important for assuring their safety. To this end, we identified mutations in the attenuated CPV 9985-46 vaccine strain that arose during serial passage in Crandell-Rees feline kidney cells by comparison with the wild-type counterpart, as well as minimal determinants of the loss of virulence. Four amino acid substitutions (N93K, G300V, T389N and V562L) in VP2 of strain 9985-46 significantly restricted infection in canine A72 cells...
October 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28973725/full-length-genomic-and-molecular-characterization-of-canine-parvovirus-in-dogs-from-north-of-brazil
#7
S P Silva, L N P P Silva, E D L Rodrigues, J F Cardoso, F N Tavares, W M Souza, C M P Santos, F M S Martins, I S Jesus, T C Brito, T P C Moura, M R T Nunes, L M N Casseb, E Silva Filho, A R Casseb
With the objective of characterizing Canine parvovirus (CPV) from some suspected fecal samples of dogs collected from the Veterinarian Hospital in Belém city, five positive samples were found by PCR assay and an update molecular characterization was provided of the CPV-2 circulation in Belém. Through sequencing of the complete DNA sequences (NS1, NS2, VP1, and VP2 genes), the CPV-2 strain was identified as CPV-2b (Asn426Asp) circulating in Belém. The CPV-2b strain with a different change at the position Tyr324Leu was detected in all samples assessed and thus reported for the first time for the scientific community...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28967558/oncolytic-h-1-parvovirus-shows-safety-and-signs-of-immunogenic-activity-in-a-first-phase-i-iia-glioblastoma-trial
#8
Karsten Geletneky, Jacek Hajda, Assia L Angelova, Barbara Leuchs, David Capper, Andreas J Bartsch, Jan-Oliver Neumann, Tilman Schöning, Johannes Hüsing, Birgit Beelte, Irina Kiprianova, Mandy Roscher, Rauf Bhat, Andreas von Deimling, Wolfgang Brück, Alexandra Just, Veronika Frehtman, Stephanie Löbhard, Elena Terletskaia-Ladwig, Jeremy Fry, Karin Jochims, Volker Daniel, Ottheinz Krebs, Michael Dahm, Bernard Huber, Andreas Unterberg, Jean Rommelaere
Oncolytic virotherapy may be a means of improving the dismal prognosis of malignant brain tumors. The rat H-1 parvovirus (H-1PV) suppresses tumors in preclinical glioma models, through both direct oncolysis and stimulation of anticancer immune responses. This was the basis of ParvOryx01, the first phase I/IIa clinical trial of an oncolytic parvovirus in recurrent glioblastoma patients. H-1PV (escalating dose) was administered via intratumoral or intravenous injection. Tumors were resected 9 days after treatment, and virus was re-administered around the resection cavity...
August 24, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28962582/low-levels-of-antibodies-against-common-viruses-associate-with-anti-citrullinated-protein-antibody-positive-rheumatoid-arthritis-implications-for-disease-aetiology
#9
Natalia Sherina, Hulda S Hreggvidsdottir, Camilla Bengtsson, Monika Hansson, Lena Israelsson, Lars Alfredsson, Karin Lundberg
BACKGROUND: Infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (RA). However, studies investigating this hypothesis in RA show conflicting results. These studies often lack well-matched control populations, and many do not include data on autoantibodies, genetic risk factors and other environmental factors, which are known to contribute to disease only in subgroups of patients. In the present study, we have therefore examined the role of Epstein-Barr virus (EBV), cytomegalovirus (CMV) and parvovirus B19 (B19) in RA aetiology, by analysing anti-viral antibodies in relation to anti-citrullinated protein antibodies (ACPA), smoking, HLA-DRB1 shared epitope (SE) alleles, and clinical parameters, in both RA patients and matched controls...
September 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28961998/human-parvovirus-b19-b19v-up-regulates-cxcr4-surface-expression-of-circulating-angiogenic-cells-implications-for-cardiac-ischemia-in-b19v-cardiomyopathy
#10
Caroline Schmidt-Lucke, Thomas Zobel, Felicitas Escher, Carsten Tschöpe, Dirk Lassner, Uwe Kühl, Knut Gubbe, Hans-Dieter Volk, Heinz-Peter Schultheiss
Background: Human parvovirus B19 (B19V) infection and damage of circulating angiogenic cells (CAC) results in dysfunctional endogenous vascular repair (DEVR) with secondary end-organ damage. Trafficking of CAC is regulated by SDF-1α and the respective receptor CXCR4. We thus tested the hypothesis of a deregulated CXCR4/SDF-1α axis in symptomatic B19V-cardiomyopathy. Methods: CAC were infected in vitro with B19V and transfected with B19V-components. Read-out were: CXCR4-expression and migratory capacity at increasing doses of SDF-1α...
August 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28960143/antigenicity-analysis-of-human-parvovirus-b19-vp1u-protein-in-the-induction-of-anti-phospholipid-syndrome
#11
Chun-Yu Lin, Chun-Ching Chiu, Ju Cheng, Chia-Yun Lin, Ya-Fang Shi, Chun-Chou Tsai, Bor-Show Tzang, Tsai-Ching Hsu
Mounting evidence suggests a connection between human parvovirus B19 (B19) and autoimmune diseases, and especially an association between the B19-VP1 unique region (VP1u) and antiphospholipid syndrome (APS). However, little is known about the antigenicity of B19-VP1u in the induction of APS-like syndrome. To elucidate the antigenicity of B19-VP1u in the induction of APS, N-terminal truncated B19-VP1u (tVP1u) proteins were prepared to immunize Balb/c mice to generate antibodies against B19-tVP1u proteins. The secreted phospholipase A2 (sPLA2) activities and binding specificity of mice anti-B19-tVP1u antibodies with cardiolipin (CL) and beta-2-glycoprotein I (β2GPI) were evaluated by performing immunoblot, ELISA and absorption experiments...
September 29, 2017: Virulence
https://www.readbyqxmd.com/read/28957693/interferon-omega-current-status-in-clinical-applications
#12
REVIEW
Shi-Fang Li, Fu-Rong Zhao, Jun-Jun Shao, Yin-Li Xie, Hui-Yun Chang, Yong-Guang Zhang
Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases...
September 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28951104/detection-of-human-parvovirus-b19-in-serum-samples-from-children-under-5-years-of-age-with-rash-fever-illnesses-in-democratic-republic-of-the-congo
#13
Tony Bokalanga Wawina, Olivier Mbaya Tshiani, Steve Mundeke Ahuka, Elisabeth Simbu Pukuta, Michel Ntetani Aloni, Christopher Kasanga, Jean-Jacques Tamfum Muyembe
BACKGROUND: Human parvovirus B19 (B19V) infection has been demonstrated to be associated with rash-fever illnesses. The present study aimed to investigate B19V as an aetiological agent of rash-fever syndromes in Congolese children confirmed as measles and rubella IgM negative. To do this, the ELISA IgM test and PCR were performed for screening of B19V. METHODS: A total of 177 archived sera were randomly selected from measles biobank of the National Institute for Biomedical Research (INRB)...
September 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28947335/epidemiology-and-molecular-characterization-of-protoparvoviruses-infecting-wild-raccoons-procyon-lotor-in-british-columbia-canada
#14
Marta Canuti, Ann P Britton, Stephanie M Graham, Andrew S Lang
Feline panleukopenia virus (FPV) and canine parvovirus 2 (CPV-2) belong to the species Carnivore protoparvovirus 1. While FPV has been endemic in cats for many years, CPV-2 emerged at the end of the 1970s and 3 antigenic variants (CPV-2a, b and c) are currently circulating in domestic and wild animals. Although raccoons played a fundamental role in the emergence of CPV-2a in dogs, knowledge about protoparvoviruses in these animals is still limited. We investigated 72 raccoons found dead or injured in southern British Columbia (BC), Canada, between 2009 and 2017...
September 22, 2017: Virus Research
https://www.readbyqxmd.com/read/28947147/differentiation-of-minute-virus-of-mice-and-mouse-parvovirus-by-high-resolution-melting-curve-analysis
#15
Dan Rao, Miaoli Wu, Jing Wang, Wen Yuan, Yujun Zhu, Feng Cong, Fengjiao Xu, Yuexiao Lian, Bihong Huang, Qiwen Wu, Meili Chen, Yu Zhang, Ren Huang, Pengju Guo
Murine parvovirus is one of the most prevalent infectious pathogens in mouse colonies. A specific primer pair targeting the VP2 gene of minute virus of mice (MVM) and mouse parvovirus (MPV) was utilized for high resolution melting (HRM) analysis. The resulting melting curves could distinguish these two virus strains and there was no detectable amplification of the other mouse pathogens which included rat parvovirus (KRV), ectromelia virus (ECT), mouse adenovirus (MAD), mouse cytomegalovirus (MCMV), polyoma virus (Poly), Helicobactor hepaticus (H...
September 23, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28946175/parameters-associated-with-adverse-fetal-outcomes-in-parvovirus-b19-congenital-infection
#16
Isabela Karine Rodrigues Agra, Antonio Gomes Amorim Filho, Lawrence Hsu Lin, Sckarlet Ernandes Biancolin, Rossana Pulcineli Vieira Francisco, Maria de Lourdes Brizot
Objective To investigate the clinical and sonographic parameters associated with adverse fetal outcomes in patients with congenital parvovirus B19 infection managed by intrauterine transfusion. Methods This was a single-center retrospective study conducted from January 2005 to December 2016 that assessed patients with singleton pregnancies with fetal parvovirus infection confirmed by a polymerase chain reaction of the amniotic fluid or fetal blood samples who underwent at least one intrauterine transfusion...
September 25, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28945149/risk-of-developing-antiphospholipid-antibodies-following-viral-infection-a-systematic-review-and-meta-analysis
#17
N Abdel-Wahab, S Talathi, M A Lopez-Olivo, M E Suarez-Almazor
Objective The objective of this paper is to conduct a systematic review and meta-analysis on the risk of developing elevated antiphospholipid (aPL) antibodies and related thromboembolic and/or pregnancy events following a viral infection. Method We searched Medline, EMBASE, Web of Science, PubMed ePubs, and Cochrane Central Register of Controlled Trials through June 2016. Independent observational studies of elevated aPL antibodies in patients with a viral infection compared with controls or patients with lupus were included...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28941869/transcription-associated-mutational-pressure-in-the-parvovirus-b19-genome-reactivated-genomes-contribute-to-the-variability-of-viral-populations
#18
Vladislav Victorovich Khrustalev, Marina Anatolyevna Ermalovich, Judith M Hübschen, Tatyana Aleksandrovna Khrustaleva
In this study we used non-overlapping parts of the two long open reading frames coding for nonstructural (NS) and capsid (VP) proteins of all available sequences of the Parvovirus B19 subgenotype 1a genome and found out that the rates of A to G, C to T and A to T mutations are higher in the first long reading frame (NS) of the virus than in the second one (VP). This difference in mutational pressure directions for two parts of the same viral genome can be explained by the fact of transcription of just the first long reading frame during the lifelong latency in nonerythroid cells...
December 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28935611/introduction-of-canine-parvovirus-2-into-wildlife-on-the-island-of-newfoundland-canada
#19
Marta Canuti, Bruce Rodrigues, Hugh G Whitney, Andrew S Lang
Canine parvovirus-2 (CPV-2) and feline panleukopenia virus (FPV) (species Carnivore protoparvovirus 1, family Parvoviridae) cause a severe gastrointestinal disease associated with immune depression in a broad range of terrestrial carnivores. We report here the first molecular epidemiological investigation of protoparvoviruses on the Island of Newfoundland, Canada. In particular, we investigated red foxes (Vulpes vulpes deletrix) and lynx (Lynx canadensis subsolanus), two autochthonous species, and coyotes (Canis latrans), which immigrated onto the island during the 1980s...
September 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28935566/construction-of-protein-functionalized-virus-like-particles-of-parvovirus-b19
#20
Ismael Bustos-Jaimes, Ricardo Arturo Soto-Román, Isabel Alejandra Gutiérrez-Landa, Josefina Valadez-García, Carla Lizbeth Segovia-Trinidad
Decoration of virus-like particles (VLPs) expands the repertory of functions these particles can display. In the last years, VLPs have successfully been used as scaffolds to present different molecules, frequently through the specific reaction of chemical groups on the surface of the particles, or by protein engineering when the presentation of peptides or proteins is the primary goal. VLPs of parvovirus B19 (B19V), have been previously produced in vitro and its stability and ability to assemble into hybrid particles composed of wild-type and chimeric proteins evidenced their potential as research tools...
September 19, 2017: Journal of Biotechnology
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