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Human parvovirus B19

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https://www.readbyqxmd.com/read/29688863/infection-status-of-human-parvovirus-b19-cytomegalovirus-and-herpes-simplex-virus-1-2-in-women-with-first-trimester-spontaneous-abortions-in-chongqing-china
#1
Ya-Ling Gao, Zhan Gao, Miao He, Pu Liao
BACKGROUND: Infection with Parvovirus B19 (B19V), Cytomegalovirus (CMV) and Herpes Simplex Virus-1/2 (HSV-1/2) may cause fetal loses including spontaneous abortion, intrauterine fetal death and non-immune hydrops fetalis. Few comprehensive studies have investigated first-trimester spontaneous abortions caused by virus infections in Chongqing, China. Our study intends to investigate the infection of B19V, CMV and HSV-1/2 in first-trimester spontaneous abortions and the corresponding immune response...
April 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29663448/seroprevalence-molecular-epidemiology-and-quantitation-of-parvovirus-b19-dna-levels-in-iranian-blood-donors
#2
Maryam Zadsar, Arezoo Aghakhani, Mohammad Banifazl, Monireh Kazemimanesh, Seyed Morteza Tabatabaei Yazdi, Setareh Mamishi, Anahita Bavand, Mona Sadat Larijani, Amitis Ramezani
Human parvovirus B19 (B19) infection is common among blood donors, and healthy blood donors can transmit virus via transfusion. Due to resistance of B19 to viral inactivation methods, there is a potential concern regarding transfusion safety in blood products. We aimed to determine the seroprevalence, molecular epidemiology and quantitation of B19 DNA levels in blood donors in Tehran, Iran. 500 blood donors from Blood Transfusion Research Center were studied. ELISA was used for detection of B19 IgG and IgM and nested PCR was carried out for detection of B19 DNA...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29649594/detection-of-human-parvovirus-b19-infection-in-the-thymus-of-patients-with-thymic-hyperplasia-associated-myasthenia-gravis
#3
Li Gong, Yanhong Li, Xinyi Li, Qian Tu, Xiaorong Mou, Shumei Wang, Yi Wan, Qiang Lu, Juzheng Wang, Wendong Zhang, Shaojun Zhu, Xiujuan Han, Li Yao, Jiarui Zhang, Gaosheng Huang, Wei Zhang
OBJECTIVE: To investigate the association between human parvovirus B19 (B19V) infection in the thymus and myasthenia gravis (MG). METHODS: The presence of human B19V DNA and protein was assessed in 138 samples, including 68 thymic hyperplasia (39 with MG), 58 thymoma (23 with MG), and 12 normal thymus tissues, by nested polymerase chain reaction, immunohistochemistry, laser capture microdissection, and sequencing in a double-blinded manner. RESULTS: B19V DNA was mainly detected in thymic hyperplasia, and the positive rate (41...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29645287/seroprevalence-molecular-epidemiology-and-quantitation-of-parvovirus-b19-dna-levels-in-iranian-blood-donors
#4
Maryam Zadsar, Arezoo Aghakhani, Mohammad Banifazl, Monireh Kazemimanesh, Seyed Morteza Tabatabaei Yazdi, Setareh Mamishi, Anahita Bavand, Mona Sadat Larijani, Amitis Ramezani
Human parvovirus B19 (B19) infection is common among blood donors, and healthy blood donors can transmit virus via transfusion. Due to resistance of B19 to viral inactivation methods, there is a potential concern regarding transfusion safety in blood products. We aimed to determine the seroprevalence, molecular epidemiology and quantitation of B19 DNA levels in blood donors in Tehran, Iran. 500 blood donors from Blood Transfusion Research Center were studied. ELISA was used for detection of B19 IgG and IgM and nested PCR was carried out for detection of B19 DNA...
April 12, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29587847/high-sensitivity-virus-and-mycoplasma-screening-test-reveals-high-prevalence-of-parvovirus-b19-infection-in-human-synovial-tissues-and-bone-marrow
#5
Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya
BACKGROUND: Latent microorganism infection is a safety concern for the clinical application of mesenchymal stem cells (MSCs). The aim of this study is to investigate the frequencies and sensitivities of the latent virus and mycoplasma infections in synovium, bone marrow, peripheral blood cells, and blood plasma and cultured synovial MSCs. METHODS: Total DNA and RNA of the synovium (n = 124), bone marrow (n = 123), peripheral blood cells (n = 121), plasma (n = 121), and 14-day cultured synovial MSCs (n = 63) were collected from patients who underwent total knee arthroplasty or anterior ligament reconstruction after written informed consents were obtained...
March 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29531655/parvovirus-b19-triggered-acute-hemolytic-anemia-and-thrombocytopenia-in-a-child-with-evans-syndrome
#6
Panagiota Zikidou, Anastassia Grapsa, Zoe Bezirgiannidou, Athanassios Chatzimichael, Elpis Mantadakis
Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals. Case report: We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with the presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29457859/post-infectious-acute-glomerulonephritis-with-podocytopathy-induced-by-parvovirus-b19-infection
#7
Satoshi Hara, Masayoshi Hirata, Kiyoaki Ito, Ichiro Mizushima, Hiroshi Fujii, Kazunori Yamada, Michio Nagata, Mitsuhiro Kawano
Human parvovirus B19 infection causes a variety of glomerular diseases such as post-infectious acute glomerulonephritis and collapsing glomerulopathy. Although each of these appears independently, it has not been fully determined why parvovirus B19 provokes such a variety of different glomerular phenotypes. Here, we report a 68-year-old Japanese man who showed endocapillary proliferative glomerulonephritis admixed with podocytopathy in association with parvovirus B19 infection. The patient showed acute onset of heavy proteinuria, microscopic hematuria and kidney dysfunction with arthralgia and oliguria after close contact with a person suffering from erythema infectiosum...
March 2018: Pathology International
https://www.readbyqxmd.com/read/29353816/human-parvovirus-b19-associated-hematopathy-in-hiv-disease-need-for-clinicopathological-revisit
#8
Nasir Idris Abdullahi, Medugu Jessy Thomas, Amos Dangana
No abstract text is available yet for this article.
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29333409/human-parvovirus-b19-and-parvovirus-4-among-iranian-patients-with-hemophilia
#9
Davod Javanmard, Masood Ziaee, Hadi Ghaffari, Mohammad Hasan Namaei, Ahmad Tavakoli, Hamidreza Mollaei, Mohsen Moghoofei, Helya Sadat Mortazavi, Seyed Hamidreza Monavari
Background: Human parvovirus B19 (B19V) is one of the smallest DNA viruses and shows great resistance to most disinfectants. Therefore, it is one of the common contaminant pathogens present in blood and plasma products. Parvovirus 4 (PARV4) is a newly identified parvovirus, which is also prevalent in parenteral transmission. In this study, we aimed to evaluate the prevalence of B19V and PARV4 DNA among patients with hemophilia in Birjand County in eastern Iran. Methods: This was a cross-sectional epidemiological study comprising nearly all people with hemophilia in this region...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29297965/the-impact-of-alternative-donor-types-on-viral-infections-in-pediatric-hematopoietic-stem-cell-transplantation
#10
D Atay, A Akcay, F Erbey, G Ozturk
Viral infections remain one of the most important complications following allogeneic HSCT. Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral infections and the outcome of one hundred and seventy-one pediatric patients (median 7.38 years) who underwent allogeneic HSCT from matched related donor (MRD, n = 71), 10 of 10 HLA allele-matched unrelated donors (MUD1; n = 29), 9 of 10 HLA allele-matched unrelated donors (MUD2; n = 40), and haploidentical donors (n = 31)...
March 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29277833/human-parvovirus-b19-associated-hematopathy-in-hiv-disease-need-for-clinicopathological-revisit
#11
Idris Abdullahi Nasir, Jessy Thomas Medugu, Amos Dangana
No abstract text is available yet for this article.
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29237843/human-parvovirus-b19-utilizes-cellular-dna-replication-machinery-for-viral-dna-replication
#12
Wei Zou, Zekun Wang, Min Xiong, Aaron Yun Chen, Peng Xu, Safder S Ganaie, Yomna Badawi, Steve Kleiboeker, Hiroshi Nishimune, Shui Qing Ye, Jianming Qiu
Human parvovirus B19 (B19V) infection of human erythroid progenitor cells (EPCs) induces a DNA damage response and cell cycle arrest at late S phase, which facilitates viral DNA replication. However, it is not clear exactly which cellular factors are employed by this single-stranded DNA virus. Here, we used microarrays to systematically analyze the dynamic transcriptome of EPCs infected with B19V. We found that DNA metabolism, DNA replication, DNA repair, DNA damage response, cell cycle, and cell cycle arrest pathways were significantly regulated after B19V infection...
March 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29186956/how-viruses-infiltrate-the-central-nervous-system
#13
A Michalicová, K Bhide, M Bhide, A Kováč
Central nervous system is protected by the blood-brain barrier, which represents a physical, metabolic and transport barrier and is considered to be a part of a highly dynamic system termed neurovascular unit. Several pathogens, among them viruses, are able to invade the brain. Traversal of viruses across the blood-brain barrier is an essential step for the invasion of the central nervous system and can occur by different mechanisms - by paracellular, transcellular and/or by "Trojan horse" pathway...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29185251/ultrasound-indications-for-maternal-storch-testing-in-pregnancy
#14
Cora Alexandra Voekt, Therese Rinderknecht, Hans Hellmuth Hirsch, Annette Blaich, Irene Mathilde Hösli
AIMS OF THE STUDY: Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of serologies to detect possible maternal STORCH infections encompassing syphilis, Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, and others (human immunodeficiency virus, hepatitis B and C, parvovirus B19, enterovirus, varicella zoster, and Leptospira interrogans). The value of indiscriminate testing for infections upon the detection of fetal ultrasound abnormalities has been questioned...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29184906/parvovirus-b19-in-the-context-of-hematopoietic-stem-cell-transplantation-evaluating-cell-donors-and-recipients
#15
Bianca E Gama, Vanessa E Emmel, Michelle Oliveira-Silva, Luciana M Gutiyama, Leonardo Arcuri, Marta Colares, Rita de Cássia Tavares, Luis F Bouzas, Eliana Abdelhay, Rocio Hassan
Background: Parvovirus B19 (B19V) is a common human pathogen, member of the family Parvoviridae. Typically, B19V has been found to infect erythroid progenitors and cause hematological disorders, such as anemia and aplastic crisis. However, the persistence of genomic deoxyribonucleic acid (DNA) has been demonstrated in tonsils, liver, skin, brain, synovial, and testicular tissues as well as bone marrow, for both symptomatic and asymptomatic subjects. Although the molecular and cellular mechanisms of persistence remain undefined, it raises questions about potential virus transmissibility and its effects in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients...
November 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29170063/incidence-and-progression-of-parvovirus-b19-infection-and-molecular-changes-in-circulating-b19v-strains-in-children-with-haematological-malignancy-a-follow-up-study
#16
Amita Jain, Parul Jain, Archana Kumar, Shantanu Prakash, Danish Nasar Khan, Ravi Kant
The present study was planned to estimate the incidence of human Parvovirus B19 infection and understand its progression in children suffering with hematological malignancy. The circulating B19V genotypes and viral mutations occurring in strains of B19V over one-year period were also studied. Children with malignancies were enrolled consecutively and were followed up for one-year period. Serum sample was collected at the time of enrolment and each follow up visit and was tested for anti B19V IgG and IgM as well as for B19V DNA...
January 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29096233/parvovirus-b19-infection-in-pregnancy-awareness-and-opportunities
#17
REVIEW
Francesca Bonvicini, Gloria Bua, Giorgio Gallinella
Parvovirus B19 (B19V) is a human pathogenic virus associated with a wide range of clinical conditions. In pregnancy, B19V poses a potential hazard to the fetus as crossing the placental barrier and infecting erythroid progenitor cells in bone marrow and liver, it blocks fetal erythropoiesis leading to profound anemia, hydrops and/or fetal death. The virus is not regarded as a teratogen, however more scientific awareness is emerging on mechanisms and consequences of intrauterine infection and possible sequelae in the neonatal development...
December 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29095139/parvovirus-b19-in-hiv-adult-patients-with-different-cd4-lymphocyte-counts
#18
Mauro Sebastian Pedranti, Gonzalo Rodriguez-Lombardi, Romina Bracciaforte, Natalia Romano, Pablo Lujan, Brenda Ricchi, Jorge Mautino, Maria Pilar Adamo
PURPOSE: Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. METHODOLOGY: We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients...
December 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29093386/the-impact-of-human-parvovirus-b19-infection-on-heart-failure-and-anemia-with-reference-to-iron-metabolism-markers-in-an-adult-woman
#19
Yuya Nakamura, Isao Ohsawa, Yoshikazu Goto, Hokuto Namba, Yusuke Dodo, Mayumi Tsuji, Yuji Kiuchi, Masahiro Inagaki, Hiromichi Gotoh
A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection...
February 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29076102/epidemiological-profile-of-acute-viral-encephalitis
#20
Rajesh Kumar, Pankaj Kumar, Manoj Kumar Singh, Dipti Agarwal, Bendangienla Jamir, Shashi Khare, Samrendra Narayan
OBJECTIVE: To study the etiology and clinico-epidemiological profile of acute viral encephalitis in children with acute encephalitis syndrome (AES). METHODS: An observational study including 100 patients fulfilling the criteria for AES was conducted in children of age group 1 mo - 16 y. Viral isolation was done on RD cells, HEp-2 cells and Vero cells from the cerebrospinal fluid samples of suspected viral encephalitis (VE) cases. An enzyme immunoassay for IgM antibodies was performed for measles, mumps, Varicella zoster virus (VZV), Herpes simplex virus 1 (HSV1) and Japanese encephalitis virus (JEV)...
October 27, 2017: Indian Journal of Pediatrics
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