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Human parvovirus B19

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https://www.readbyqxmd.com/read/27914222/molecular-diversity-of-human-parvovirus-b19-during-two-outbreaks-of-erythema-infectiosum-in-brazil
#1
Rita de Cássia Nasser Cubel Garcia, Renata Freire Alves Pereira, Kátia Martins Lopes de Azevedo, Tatiana Xavier de Castro, Francisco C A Mello, Sérgio Setubal, Marilda M Siqueira, David Brown, Solange Artimos de Oliveira
This study was conducted to provide information on the genetic diversity of human parvovirus B19 (B19V) circulating in the municipality of Niterói, Rio de Janeiro, Southeast Brazil during 1996-2006, a period with two distinct outbreaks of B19V infection: 1999-2000 and 2004-2005. A total of 27 sera from patients with erythema infectiosum (EI) and five sera from HIV-infected patients that tested positive for B19V DNA during the study period were analyzed. To genotype B19V strains, a semi-nested PCR for partial amplification of the capsid gene was performed and sequence analysis revealed that 31 sequences belonged to subgenotype 1a (G1a) of the main genotype 1 and one sequence was characterized as subgenotype 3b (G3b)...
November 30, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27865549/anaemia-and-fever-in-kidney-transplant-the-role-of-human-parvovirus-b19
#2
Yanet Parodis López, Raquel Santana Estupiñán, Silvia Marrero Robayna, Roberto Gallego Samper, Fernando Henríquez Palop, José Carlos Rivero Vera, Rafael Camacho Galán, María José Pena López, Nery Sablón González, Fayna González Cabrera, Elena Oliva Dámaso, Nicanor Vega Díaz, José Carlos Rodríguez Pérez
Infections remain an issue of particular relevance in renal transplant patients, particularly viral infections. Human parvovirus B19 infection causes severe refractory anaemia, pancytopenia and thrombotic microangiopathy. Its presence is recognized by analysing blood polymerase chain reaction (PCR) and by the discovery of typical giant proerythroblasts in the bone marrow. We report the case of a 65 year-old man with a history of deceased donor renal transplant in September 2014. At 38 days after the transplant, the patient presented progressive anaemia that was resistant to erythropoiesis-stimulating agents...
November 16, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27809499/dna-binding-and-cleavage-by-human-parvovirus-b19-ns1-nuclease-domain
#3
Jonathan L Sanchez, Zachary Romero, Angelica Quinones, Kristiane R Torgeson, Nancy C Horton
Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses, including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, cardiomyopathy and also possibly the triggering of any number of different autoimmune diseases. B19V NS1 is a multi-domain protein that plays a critical role in viral replication, with predicted nuclease, helicase, and gene transactivation activities. Herein we investigate the biochemical activities of the nuclease domain (residues 2-176) of B19V NS1 (NS1-nuc) in sequence-specific DNA binding of the viral origin of replication sequences, as well as those of promoter sequences including the viral p6 and the human p21, TNFα, and IL-6 promoters previously identified in NS1-dependent transcriptional transactivation...
November 4, 2016: Biochemistry
https://www.readbyqxmd.com/read/27806994/human-parvoviruses
#4
REVIEW
Jianming Qiu, Maria Söderlund-Venermo, Neal S Young
Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed...
January 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/27772627/not-the-usual-viral-suspects-parvovirus-b19-west-nile-virus-and-human-t-cell-lymphotrophic-virus-infections-after-kidney-transplantation
#5
REVIEW
Raymund R Razonable
Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. In this review article, the epidemiology, clinical manifestations, diagnosis and treatment of less common viruses are discussed in the setting of kidney transplantation...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27761646/-viral-arthritis-and-vasculitis
#6
U Sixdorf, E Märker-Hermann
Viral arthritis and vasculitis are important differential diagnoses primarily in patients with acute polyarticular arthritis in association with fever and rash, in populations specially at risk and in returning travellers. Parvovirus B19 is the most frequent cause of viral arthritis in Europe, whereas rubella, hepatitis B and C viruses have become less common. Due to worldwide tourism arthritogenic alphaviruses, which are transmitted by mosquito vectors have come into the focus of tropical medicine and rheumatology...
October 19, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27748859/human-parvovirus-b19-antibodies-induce-altered-membrane-protein-expression-and-apoptosis-of-bewo-trophoblasts
#7
Bor-Show Tzang, Szu-Yi Chiang, Hsu-Chin Chan, Chung-Hsien Liu, Tsai-Ching Hsu
Human parvovirus B19 (B19) is harmful during pregnancy since it can be vertically transmitted to the developing fetus. In addition, the anti‑B19 antibodies induced by B19 infection are believed to have a cytopathic role in B19 transmission; however, knowledge regarding the effects of anti‑B19 antibodies during pregnancy is limited. To investigate the possible roles of anti‑B19 antibodies during pregnancy, the present study examined the effects of anti‑B19‑VP1 unique region (VP1u), anti‑B19‑VP2 and anti‑B19‑nonstructural protein 1 (NS1) immunoglobulin G (IgG) antibodies on BeWo trophoblasts...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27727702/human-parvovirus-b19-infection-with-red-cell-aplasia-and-idiopathic-thrombocytopenic-purpura
#8
P Ganesh, Subbalaxmi Mvs, Swaroopa Reddy, Ysn Raju
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27639978/existence-of-various-human-parvovirus-b19-genotypes-in-chinese-plasma-pools-genotype-1-genotype-3-putative-intergenotypic-recombinant-variants-and-new-genotypes
#9
Junting Jia, Yuyuan Ma, Xiong Zhao, Chaoji Huangfu, Yadi Zhong, Chi Fang, Rui Fan, Maomin Lv, Jingang Zhang
BACKGROUND: Human parvovirus B19 (B19V) is a frequent contaminant of blood and plasma-derived medicinal products. Three distinct genotypes of B19V have been identified. The distribution of the three B19V genotypes has been investigated in various regions or countries. However, in China, data on the existence of different B19V genotypes are limited. METHODS: One hundred and eighteen B19V-DNA positive source plasma pool samples collected from three Chinese blood products manufacturers were analyzed...
September 17, 2016: Virology Journal
https://www.readbyqxmd.com/read/27602415/diagnostic-and-prognostic-value-of-molecular-and-serological-investigation-of-human-parvovirus-b19-infection-during-pregnancy
#10
Maurizio Zavattoni, Stefano Paolucci, Antonella Sarasini, Beatrice Tassis, Mariangela Rustico, Aida Quarenghi, Antonio Piralla, Fausto Baldanti
To define diagnostic and prognostic markers of parvovirus B19 (B19V) fetal infection, two groups were investigated: 1) pregnant women with specific symptoms or contacts with symptomatic households (n=37); 2) mothers with pathological ultrasound findings and the relevant fetus at the time of prenatal diagnosis (n=16). In the first group, diagnosis of B19V infection was achieved using IgM detection in 29/37 (78.3%) of patients, while B19V DNA was detected in 36/37 (97.3%) of infected women. In the second group, intrauterine infection was investigated by amniocentesis (n=5), cordocentesis (n=3) or both (n=5)...
September 2016: New Microbiologica
https://www.readbyqxmd.com/read/27600725/collapsing-glomerulopathy-in-a-young-woman-with-apol1-risk-alleles-following-acute-parvovirus-b19-infection-a-case-report-investigation
#11
Whitney Besse, Sherry Mansour, Karan Jatwani, Cynthia C Nast, Ursula C Brewster
BACKGROUND: Collapsing Glomerulopathy (CG), also known as the collapsing variant of Focal Segmental Glomerulosclerosis (FSGS), is distinct in both its clinical severity and its pathophysiologic characteristics from other forms of FSGS. This lesion occurs disproportionally in patients carrying two APOL1 risk alleles, and is the classic histologic lesion resulting from Human Immunodeficiency Virus (HIV) infection of podocytes. Other viral infections, including parvovirus B19, and drugs such as interferon that perturb the immune system, have also been associated with CG...
September 6, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27552439/virome-characterisation-from-guthrie-cards-in-children-who-later-developed-acute-lymphoblastic-leukaemia
#12
G Bogdanovic, C Pou, M Barrientos-Somarribas, A Bjerkner, E Honkaniemi, T Allander, B Andersson, B Gustafsson
BACKGROUND: Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls. METHODS: DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System...
October 11, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27547655/placental-abruption-possibly-due-to-parvovirus-b19-infection
#13
Ayaka Kawabe, Yasushi Takai, Jun-Ichi Tamaru, Kouki Samejima, Hiroyuki Seki
BACKGROUND: There is concern about the development of anemia-associated fetal hydrops associated with maternal parvovirus B19 infection. Parvovirus B19 infection occurs via the globoside (P antigen) receptor, the main glycolipid of erythroid cells, which induces apoptosis. Similar findings have been reported for the P antigen of globoside-containing placental trophoblast cells. CASE DESCRIPTION: A 32-year-old woman was infected with human parvovirus B19 at week 32 of pregnancy, and had severe anemia at week 34...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27541023/agranulocytosis-under-biotherapy-in-rheumatoid-arthritis-three-cases-hypothesis-of-parvovirus-b19-involvement-in-agranulocytosis-observed-under-tocilizumab-and-rituximab-for-the-treatment-of-rheumatoid-arthritis
#14
REVIEW
C Giraud, Z Tatar, M Soubrier
Leukopenia is a considerably common complication of tocilizumab [TCZ] and rituximab [RTX] therapy. RTX-induced leukopenia typically exhibits delayed onset. While agranulocytosis has been reported linked to RTX treatment of lymphoma, this complication rarely occurs in rheumatoid arthritis (RA) treatment and, to our knowledge, has never been reported in association with TCZ therapy. We herein report four agranulocytosis cases in three patients, with the first two cases suspected to be secondary to human parvovirus B19 (PVB19) infection...
October 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27511498/serological-prevalence-of-human-parvovirus-b19-in-diseases-or-disordersrelated-to-different-human-body-systems
#15
Osman Aktaş, Hakan Aydin, Hakan Uslu
BACKGROUND/AIM: Human parvovirus B19 is a pathogen that affects different parts of the body. We planned this study because of the lack of data on B19 seroprevalence based on different body-system diseases. MATERIALS AND METHODS: The prevalence of parvovirus B19 antibodies was investigated retrospectively in 1239 patients by review of medical records from 2009-2012, according to their diseases classified under general titles in compliance with the International Classification of Diseases (ICD-10)...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27455181/diagnostic-and-prognostic-value-of-molecular-and-serological-investigation-of-human-parvovirus-b19-infection-during-pregnancy
#16
Maurizio Zavattoni, Stefano Paolucci, Antonella Sarasini, Beatrice Tassis, Mariangela Rustico, Aida Quarenghi, Antonio Piralla, Fausto Baldanti
To define diagnostic and prognostic markers of parvovirus B19 (B19V) fetal infection, two groups were investigated: 1) pregnant women with specific symptoms or contacts with symptomatic households (n=37); 2) mothers with pathological ultrasound findings and the relevant fetus at the time of prenatal diagnosis (n=16). In the first group, diagnosis of B19V infection was achieved using IgM detection in 29/37 (78.3%) of patients, while B19V DNA was detected in 36/37 (97.3%) of infected women. In the second group, intrauterine infection was investigated by amniocentesis (n=5), cordocentesis (n=3) or both (n=5)...
July 2016: New Microbiologica
https://www.readbyqxmd.com/read/27419073/atypical-rashes-in-adult-human-parvovirus-b19-infection-atypical-is-typical
#17
Yuji Hirai, Yoshihiko Takeda
No abstract text is available yet for this article.
2016: IDCases
https://www.readbyqxmd.com/read/27408426/prevalence-and-viral-load-of-human-parvovirus-b19-b19v-among-blood-donors-in-south-east-brazil
#18
Svetoslav Nanev Slavov, Katia Kaori Otaguiri, Dimas Tadeu Covas, Simone Kashima
The infection of human parvovirus B19 (B19V) is a common event in the general population, including volunteer blood donors. In some cases it can be asymptomatic and can remain persistent for a long period of time. The objective of this study was to examine the B19V DNA prevalence and viral load in first-time volunteer blood donors. Blood samples were collected from 91 primary blood donors at the Regional Blood Center of Ribeirão Preto, Southeast Brazil. Viral detection and quantitation was performed by an in-house TaqMan(®) real-time PCR with high sensitivity...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27385036/-seroprevalence-of-human-parvovirus-b19-in-children-with-fever-and-rash-in-the-north-of-tunisia
#19
A Bouafsoun, N Hannachi, H Smaoui, S H Boubaker, K Kazdaghli, D Laabidi, J Boukadida, A Kechrid
The aim of the study is to evaluate the prevalence of specific antibodies anti-human parvovirus B19 (PVB19) immunoglobulin M (IgM) and IgG in children with fever and rash. This study involved 257 children aged from 7 months to 15 years with febrile rash unrelated to measles and rubella (seronegative for IgM). The sera were examined by immunoenzymatic assay. Detection of antibodies of PVB19 was done by enzyme-linked immunosorbent assay (Elisa). In our study, prevalence of immunoglobulin G (IgG) and IgM were 44 and 11...
August 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27364410/virus-reactivations-after-autologous-hematopoietic-stem-cell-transplantation-detected-by-multiplex-pcr-assay
#20
Natsuko Inazawa, Tsukasa Hori, Masanori Nojima, Makoto Saito, Keita Igarashi, Masaki Yamamoto, Norio Shimizu, Yuko Yoto, Hiroyuki Tsutsumi
Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-HSCT between September 2010 and December 2012. Weekly whole blood samples were collected from pre- to 42 days post-HSCT, and tested for the following 13 viruses; herpes simplex virus 1 (HSV-1), HSV-2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), HHV-7, HHV-8, adeno virus (ADV), BK virus (BKV), JC virus (JCV), parvovirus B19 (B19V), and hepatitis B virus (HBV)...
February 2017: Journal of Medical Virology
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