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albumin creatinine ratio in urine in diabetic nephropathy

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https://www.readbyqxmd.com/read/27901066/greater-efficacy-of-atorvastatin-versus-a-non-statin-lipid-lowering-agent-against-renal-injury-potential-role-as-a-histone-deacetylase-inhibitor
#1
Ravi Shankar Singh, Dharmendra Kumar Chaudhary, Aradhana Mohan, Praveen Kumar, Chandra Prakash Chaturvedi, Carolyn M Ecelbarger, Madan M Godbole, Swasti Tiwari
Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have been shown to improve diabetic nephropathy. However, whether they provide protection via Histone deacetylases (HDAC) inhibition is not clear. We conducted a comparative evaluation of Atorvastatin (AT) versus the non-statin cholesterol-lowering drug, Ezetimibe (EZT) on severity of diabetic nephropathy. Streptozotocin-treated male Wistar rats were fed a cholesterol-supplemented diet and gavaged daily with vehicle, AT or EZT. Control rats received normal diet and gavaged vehicle (n = 8-9/group)...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27834062/comparison-of-urine-albumin-to-creatinine-ratio-acr-between-acr-strip-test-and-quantitative-test-in-prediabetes-and-diabetes
#2
Eun Hee Nah, Seon Cho, Suyoung Kim, Han Ik Cho
BACKGROUND: Albuminuria is generally known as a sensitive marker of renal and cardiovascular dysfunction. It can be used to help predict the occurrence of nephropathy and cardiovascular disorders in diabetes. Individuals with prediabetes have a tendency to develop macrovascular and microvascular pathology, resulting in an increased risk of retinopathy, cardiovascular diseases, and chronic renal diseases. We evaluated the clinical value of a strip test for measuring the urinary albumin-to-creatinine ratio (ACR) in prediabetes and diabetes...
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27833513/plasma-and-urinary-type-iv-collagen-levels-for-early-detection-of-nephropathy-in-type-2-diabetes-mellitus-patients
#3
K Balu Mahendran, M Vijaya Bhaskar, K Santha, R Inmozhi, K K Perumal
BACKGROUND: Diabetic nephropathy is a major complication with high morbidity and mortality, and leads to end stage renal disease (ESRD). Type IV collagen is the main component of the glomerular basement membrane (GBM) and the extracellular matrix. The thickening of the GBM is due to accumulation of type IV collagen and alterations in its structure and composition. AIM: The aim of this study was to evaluate the association of plasma and urine type IV collagen with albuminuria status and to determine the clinical implications of type IV collagen as a marker in the early stage of diabetic nephropathy...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27756187/endocan-and-albuminuria-in-type-2-diabetes-mellitus
#4
Mehmet Ali Cikrikcioglu, Zeynep Erturk, Elif Kilic, Kenan Celik, Iskender Ekinci, Ayse Irem Yasin Cetin, Tuba Ozkan, Guven Cetin, Shute Ailia Dae, Rumeyza Kazancioglu, Reha Erkoc
BACKGROUND: Endocan is a newly identified proteoglycan released from endothelium, stimulating angiogenesis and when increased, indicates endothelial activation (inflammation). Our aim was to examine the association between serum endocan levels and urine albumin-creatinine ratio (UACR). METHOD: One hundred and thirty-seven patients with type 2 diabetes mellitus and normal serum creatinine who had no co-morbidities other than hypertension, diabetic nephropathy, retinopathy, or neuropathy were divided into normoalbuminuria (G1), microalbuminuria (G2), and macroalbuminuria (G3) groups and compared cross-sectionally regarding serum endocan levels...
October 18, 2016: Renal Failure
https://www.readbyqxmd.com/read/27546995/association-of-serum-adropin-concentrations-with-diabetic-nephropathy
#5
Wenchao Hu, Li Chen
Objective. Adropin is a newly identified regulatory protein encoded by the Enho gene and is critically involved in energy homeostasis and insulin sensitivity. This study aims to determine the correlation of serum adropin concentrations with diabetic nephropathy (DN). Methods. This study consisted of 245 patients with type 2 diabetes mellitus (T2DM) and 81 healthy subjects. Then T2DM patients were divided into normoalbuminuria, microalbuminuria, and macroalbuminuria subgroups based on urine albumin to creatinine ratio (ACR)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27520462/retinal-vascular-geometry-and-its-association-to-microvascular-complications-in-patients-with-type-1-diabetes-the-danish-cohort-of-pediatric-diabetes-1987-dcpd1987
#6
M L Rasmussen, R Broe, U Frydkjaer-Olsen, B S Olsen, H B Mortensen, T Peto, J Grauslund
PURPOSE: To examine associations between retinal vascular geometry (tortuosity, branching coefficient [BC] and length-diameter ratio [LDR]) and diabetic proliferative retinopathy (PDR), nephropathy, and peripheral neuropathy in patients with type 1 diabetes mellitus (T1DM). METHODS: A cohort of patients with T1DM participated in a clinical examination in 2011. Blood and urine analyses were done and retinal images taken. PDR was defined as Early Treatment Diabetic Retinopathy Study level 61 or above, nephropathy as albumin-creatinin ratio ≥300 mg/g, and neuropathy as vibration perception threshold >25 Volt...
August 12, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27500547/interleukin-6-gene-polymorphisms-correlate-with-the-progression-of-nephropathy-in-chinese-patients-with-type-2-diabetes-a-prospective-cohort-study
#7
Wen-Tsan Chang, Meng-Chuan Huang, Hsin-Fang Chung, Yen-Feng Chiu, Pao-Shan Chen, Fang-Pei Chen, Chun-Yi Lee, Shyi-Jang Shin, Shang-Jyh Hwang, Ya-Fang Huang, Chih-Cheng Hsu
AIMS: Interleukin-6 (IL-6), an inflammatory cytokine, is considered a candidate gene possibly involved in susceptibility to nephropathy in diabetes. This study aimed to examine whether IL-6 polymorphisms predict the progression of nephropathy in a prospective Chinese cohort of patients with type 2 diabetes. METHODS: A total of 568 type 2 diabetic patients with normoalbuminuria at baseline were followed up for a mean of 5.3±1.5years. Urinary albumin-to-creatinine ratio (ACR) ⩾30mg/g in two consecutive urine tests were defined as progression to diabetic nephropathy (n=143)...
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27496229/semi-individualised-chinese-medicine-treatment-as-an-adjuvant-management-for-diabetic-nephropathy-a-pilot-add-on-randomised-controlled-multicentre-open-label-pragmatic-clinical-trial
#8
Kam Wa Chan, Tai Pang Ip, Alfred Siu Kei Kwong, Sing Leung Lui, Gary Chi Wang Chan, Benjamin John Cowling, Wai Han Yiu, Dickson Wai Leong Wong, Yang Liu, Yibin Feng, Kathryn Choon Beng Tan, Loretta Yuk Yee Chan, Joseph Chi Kam Leung, Kar Neng Lai, Sydney Chi Wai Tang
INTRODUCTION: Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin-angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that the use of Chinese medicine (CM), a major form of traditional medicine used extensively in Asia, could reduce the risk of end-stage kidney disease. However, existing clinical practice guidelines are weakly evidence-based and the effect of CM remains unclear...
2016: BMJ Open
https://www.readbyqxmd.com/read/27470555/clinical-verification-of-a-novel-urinary-microrna-panal-133b-342-and-30-as-biomarkers-for-diabetic-nephropathy-identified-by-bioinformatics-analysis
#9
Sanaa Eissa, Marwa Matboli, Miram M Bekhet
BACKGROUND: Because microvascular disease is one of the major drivers of diabetic complications, early detection of diabetic nephropathy (DN) by assessing the expression of exosomal microRNAs (miRNAs) in DN patients and healthy controls, may be of clinical value. The aim of this study wasto identify a novel miRNA panel of DN by combining bioinformatics analysis of miRNA databases and clinical verification to evaluate the significance of this panel as urine biomarkers for type 2 diabetic nephropathy (T2DN)...
June 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27412828/blood-pressure-lowering-effects-of-sulodexide-depend-on-albuminuria-severity-post-hoc-analysis-of-the-sulodexide-microalbuminuria-and-macroalbuminuria-studies
#10
Rik H G Olde Engberink, Hiddo J L Heerspink, Dick de Zeeuw, Liffert Vogt
AIMS: It has been suggested that sulodexide is able to lower blood pressure (BP). This may be attributed to its ability to restore the endothelial surface layer (ESL). As ESL perturbation is known to be related to the degree of kidney damage, we investigated whether albuminuria, reflecting ESL status, modified the BP-lowering potential of sulodexide. METHODS: A post hoc analysis of the double-blind, randomized, placebo-controlled sulodexide microalbuminuria (Sun-MICRO) and macroalbuminuria (Sun-MACRO) studies, including 1056 microalbuminuric and 843 macroalbuminuric subjects with type 2 diabetes receiving maximal tolerated renin-angiotensin-aldosterone system inhibitor therapy, was carried out...
July 14, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27388615/effect-of-losartan-and-spironolactone-on-triglyceride-rich-lipoproteins-in-diabetic-nephropathy
#11
Anand Srivastava, Beverley Adams-Huet, Gloria L Vega, Robert D Toto
UNLABELLED: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) can improve dyslipidemia in patients with diabetes and albuminuria. Whether combined ACEi+ARB or ACEi+mineralocorticoid receptor blockade improves dyslipidemia is not known. We hypothesized long-term administration of either losartan 100 mg or spironolactone 25 mg once daily added onto lisinopril 80 mg once daily would improve dyslipidemia in diabetic nephropathy (DN). We measured lipid levels, very-low-density (V), intermediate-density (I), low-density (LDL), high-density (HDL) lipoprotein, LDL particle size with their respective cholesterol (C) and apolipoprotein B levels (ApoB), and urine albumin/creatinine ratio (UACR) at 12-week interval during a 48-week randomized, double-blind placebo-controlled trial in 81 patients with DN...
August 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27342958/apol1-renal-risk-variants-associate-with-reduced-cerebral-white-matter-lesion-volume-and-increased-gray-matter-volume
#12
Barry I Freedman, Crystal A Gadegbeku, R Nick Bryan, Nicholette D Palmer, Pamela J Hicks, Lijun Ma, Michael V Rocco, S Carrie Smith, Jianzhao Xu, Christopher T Whitlow, Benjamin C Wagner, Carl D Langefeld, Amret T Hawfield, Jeffrey T Bates, Alan J Lerner, Dominic S Raj, Mohammad S Sadaghiani, Robert D Toto, Jackson T Wright, Donald W Bowden, Jeff D Williamson, Kaycee M Sink, Joseph A Maldjian, Nicholas M Pajewski, Jasmin Divers
To assess apolipoprotein L1 gene (APOL1) renal-risk-variant effects on the brain, magnetic resonance imaging (MRI)-based cerebral volumes and cognitive function were assessed in 517 African American-Diabetes Heart Study (AA-DHS) Memory IN Diabetes (MIND) and 2568 hypertensive African American Systolic Blood Pressure Intervention Trial (SPRINT) participants without diabetes. Within these cohorts, 483 and 197 had cerebral MRI, respectively. AA-DHS participants were characterized as follows: 60.9% female, mean age of 58...
August 2016: Kidney International
https://www.readbyqxmd.com/read/27303100/randomized-control-trial-for-the-assessment-of-the-anti-albuminuric-effects-of-topiroxostat-in-hyperuricemic-patients-with-diabetic-nephropathy-the-etude-study
#13
Sawako Kato, Masahiko Ando, Toshihiro Mizukoshi, Takanobu Nagata, Takayuki Katsuno, Tomoki Kosugi, Naotake Tsuboi, Shoichi Maruyama
Proteinuria is an established risk factor for diabetic nephropathy. Recent studies indicate that some xanthine oxidase inhibitors have a renoprotective effect. The aim of this study was to assess whether topiroxostat reduces albuminuria in hyperuricemic patients with diabetic nephropathy and overt proteinuria. The ETUDE study is an ongoing 24-week, multicenter, open-label, randomized (1:1), parallel group study involving hyperuricemic patients with diabetic nephropathy (estimated glomerular filtration rate [eGFR] ≥ 20 mL/min/1...
May 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27273597/association-of-plasma-semaphorin-3a-with-phenotypes-of-diabetic-retinopathy-and-nephropathy
#14
Soo Hyun Kwon, Jae Pil Shin, In Taek Kim, Dong Ho Park
PURPOSE: To investigate whether diabetic retinopathy phenotypes and albuminuria are associated with the overexpression of plasma semaphorin 3A (Sema3A). METHODS: The study group with severe nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR), the diabetes without diabetic retinopathy group, and the control group without diabetes consisted of all consecutive patients who were scheduled to undergo intravitreal bevacizumab injection for treatment-naïve diabetic macular edema (DME) and senile cataract surgery, respectively...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27233502/oxidative-stress-markers-in-type-2-diabetes-patients-with-diabetic-nephropathy
#15
Su-Tze Chou, Shih-Ting Tseng
BACKGROUND: Epidemiological studies show that 5-40 % of type 2 diabetes (T2DM) patients have diabetic nephropathy, and oxidative stress is one of several underlying mechanisms. We investigated associations between oxidative stress markers and severity of diabetic nephropathy. METHODS: Fifty-nine T2DM patients from the endocrinology outpatient department were included, and their levels of oxidative stress markers were measured. Three groups were determined by their urine albumin-to-creatinine ratio (UACR): group A (UACR < 30 mg/g, n = 22); group B (30 ≤ UACR < 300 mg/g, n = 22); and group C (UACR ≥ 300 mg/g, n = 15)...
May 27, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27218216/elevated-expression-levels-of-serum-igf-1-tnf-%C3%AE-and-vegf165-may-exacerbate-type-2-diabetic-nephropathy
#16
Xiang Li, Ting-Ting Wu, Juan Chen, Wen Qiu
AIM: This study aimed to determine the associations between expressions of IGF-1, TNF-α and VEGF165 in serum, and occurrence and development of type 2 diabetic nephropathy (DN). MATERIALS AND METHODS: A total of 108 patients diagnosed as DN were randomly selected, including 50 cases microalbuminuria group, 44 cases macroalbuminuria group, and 14 cases renal insufficiency group. Meanwhile, 97 healthy people were collected as a normal control group. Urinary albumin and urine creatinine of all subjects for 24 hours were detected, with their ratio (UALB/Cr) being calculated...
May 24, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27210499/levels-of-albuminuria-and-risk-of-developing-macroalbuminuria-in-type-2-diabetes-historical-cohort-study
#17
Shoma Chida, Yoshikuni Fujita, Akifumi Ogawa, Akinori Hayashi, Raishi Ichikawa, Yuji Kamata, Akihiro Takeuchi, Koji Takano, Masayoshi Shichiri
Although increased urinary albumin excretion may increase the risk of adverse renal outcomes in patients with diabetes, it remains unclear whether microalbuminuria is associated with a higher incidence of macroalbuminuria in the absence of non-diabetic kidney events that frequently develop during the long-term course of type 2 diabetes. This historical cohort study included patients with type 2 diabetes, spot urine albumin:creatinine ratio (ACR) <300 mg/gCr and normal serum creatinine concentrations treated between August 1988 and April 2015...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27158221/evaluation-of-ischemia-modified-albumin-malondialdehyde-and-advanced-oxidative-protein-products-as-markers-of-vascular-injury-in-diabetic-nephropathy
#18
Afzal Ahmad, Poornima Manjrekar, Charu Yadav, Ashish Agarwal, Rukmini Mysore Srikantiah, Anupama Hegde
AIM: This study aimed at evaluation of ischemia-modified albumin (IMA), malondialdehyde (MDA), and advanced oxidative protein products (AOPP) as markers of vascular injury in diabetic nephropathy (DN) with derivation of cutoff values for the same. MATERIALS AND METHODS: Study population comprised 60 diabetes patients and 30 controls, with diabetes patients further categorized into three groups based on urine albumin/creatinine ratio (UACR) of <30 mg/g (diabetes without microalbuminuria), 30-300 mg/g (early DN), and >300 mg/g of creatinine (overt DN)...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27145370/cdk5-promotes-renal-tubulointerstitial-fibrosis-in-diabetic-nephropathy-via-erk1-2-ppar%C3%AE-pathway
#19
Xiaoyan Bai, Xiaoyan Hou, Jianwei Tian, Jian Geng, Xiao Li
Cyclin-dependent kinase 5 (CDK5) has been documented in podocyte injuries in diabetic nephropathy (DN), however its role in renal tubular epithelial cells has not been elucidated. We report here that CDK5 is detrimental and promotes tubulointerstitial fibrosis (TIF) via the extracellular signal-regulated kinase 1/2 (ERK1/2)/peroxisome proliferator-activated receptor gamma (PPRAγ) pathway in DN. In high glucose cultured NRK52E cells, blocking CDK5 activity inhibited epithelial-to-mesenchymal transition (EMT) and fibrosis via ERK1/2/PPARγ pathway...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27135947/effects-of-omega-3-fatty-acid-supplementation-on-diabetic-nephropathy-progression-in-patients-with-diabetes-and-hypertriglyceridemia
#20
Eugene Han, Yujung Yun, Gyuri Kim, Yong-Ho Lee, Hye Jin Wang, Byung-Wan Lee, Bong Soo Cha, Beom Seok Kim, Eun Seok Kang
Beneficial effects of omega-3 fatty acid (O3FA) supplementation in a wide range of disease condition have been well studied. However, there is limited information regarding the effects of O3FAs on chronic kidney disease (CKD), especially in diabetic nephropathy (DN) with hypertriglyceridemia. We investigate whether O3FA supplementation could help maintain renal function in patients with diabetes and hypertriglyceridemia. Total 344 type 2 diabetic patients with a history of O3FA supplementation for managing hypertriglyceridemia were included...
2016: PloS One
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