keyword
https://read.qxmd.com/read/38448714/genome-wide-identification-phylogenetic-classification-of-histone-acetyltransferase-genes-and-their-expression-analysis-in-sugar-beet-beta-vulgaris-l-under-salt-stress
#1
JOURNAL ARTICLE
Seher Yolcu, Monika Skorupa, Mehmet Emin Uras, Justyna Mazur, Ibrahim Ilker Ozyiğit
This study identified seven histone acetyltransferase-encoding genes (HATs) from Beta vulgaris L. (sugar beet) genome through bioinformatics tools and analyzed their expression profiles under salt stress. Sugar beet HATs are phylogenetically divided into four families: GNAT, MYST, CBP, and TAFII250. The BvHAT genes were differentially transcribed in leaves, stems, and roots of B. vulgaris salt-resistant (Casino) and -sensitive (Bravo) cultivars under salt stress. Histone acetylation is regulated by histone acetyltransferases (HATs), which catalyze ɛ-amino bond formation between lysine residues and acetyl groups with a cofactor, acetyl-CoA...
March 6, 2024: Planta
https://read.qxmd.com/read/38416273/involvement-of-histone-acetyltransferase-1-hat1-in-the-spermatogenesis-of-non-condensed-nuclear-sperm-in-chinese-mitten-crab-eriocheir-sinensis
#2
JOURNAL ARTICLE
Huiting Liu, Yulian Tang, Lishuang Sun, Shu Li, Lvjing Luo, Zhengyu Chen, Genliang Li
Chinese mitten crab, Eriocheir sinensis, is a decapod crustacean with a special, non-condensated nucleus in the sperm. Studies have shown that the nuclear compact state of male germ cells during the spermatogenesis is closely related to histone modification. To explore the possible role of histone acetyltransferase 1 (HAT1) in the chromatin organization during the E. sinensis spermatogenesis, we took the testis tissues of both adult and juvenile crabs as the materials of study and analyzed the biological functions of HAT1 by whole transcriptome sequencing and bioinformatics, then further analyzed the expression and distribution of HAT1 using the methods of RT-qRCR, western blotting, and immunofluorescence location...
February 28, 2024: Biochemical Genetics
https://read.qxmd.com/read/38345235/an-acetyl-click-chemistry-assay-to-measure-histone-acetyltransferase-1-acetylation
#3
JOURNAL ARTICLE
Shreenidhi Rajkumar, Danielle Dixon, Andrew M Lipchik, Joshua J Gruber
HAT1, also known as Histone acetyltransferase 1, plays a crucial role in chromatin synthesis by stabilizing and acetylating nascent H4 before nucleosome assembly. It is required for tumor growth in various systems, making it a potential target for cancer treatment. To facilitate the identification of compounds that can inhibit HAT1 enzymatic activity, we have devised an acetyl-click assay for rapid screening. In this simple assay, we employ recombinant HAT1/Rbap46, which is purified from activated human cells...
January 26, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38245973/overexpression-of-brg1-improves-early-development-of-porcine-somatic-cell-nuclear-transfer-embryos
#4
JOURNAL ARTICLE
Xuan Ren, Yi Tong, Ting Yang, Shihai Huang, Tairan Xu, Qingsong Xue, Deshun Shi, Xiangping Li
The epigenetic modification levels of donor cells directly affect the developmental potential of somatic cell nuclear transfer (SCNT) embryos. BRG1, as an epigenetic modifying enzyme, has not yet been studied in donor cells and SCNT embryos. In this study, BRG1 was overexpressed in porcine fetal fibroblasts (PFFs), its effect on chromatin openness and gene transcription was examined, subsequently, the development potential of porcine SCNT embryos was investigated. The results showed that compared with the control group, the percentage of G1 phase cells was significantly increased (32...
January 9, 2024: Theriogenology
https://read.qxmd.com/read/38086369/profiling-nuclear-cysteine-ligandability-and-effects-on-nuclear-localization-using-proximity-labeling-coupled-chemoproteomics
#5
JOURNAL ARTICLE
Qianni Peng, Eranthie Weerapana
The nucleus controls cell growth and division through coordinated interactions between nuclear proteins and chromatin. Mutations that impair nuclear protein association with chromatin are implicated in numerous diseases. Covalent ligands are a promising strategy to pharmacologically target nuclear proteins, such as transcription factors, which lack ordered small-molecule binding pockets. To identify nuclear cysteines that are susceptible to covalent liganding, we couple proximity labeling (PL), using a histone H3...
November 30, 2023: Cell Chemical Biology
https://read.qxmd.com/read/37974527/genome-scans-capture-key-adaptation-and-historical-hybridization-signatures-in-tetraploid-wheat
#6
JOURNAL ARTICLE
Demissew Sertse, Jemanesh K Haile, Ehsan Sari, Valentyna Klymiuk, Amidou N'Diaye, Curtis J Pozniak, Sylvie Cloutier, Sateesh Kagale
Tetraploid wheats (Triticum turgidum L.), including durum wheat (T. turgidum ssp. durum (Desf.) Husn.), are important crops with high nutritional and cultural values. However, their production is constrained by sensitivity to environmental conditions. In search of adaptive genetic signatures tracing historical selection and hybridization events, we performed genome scans on two datasets: (1) Durum Global Diversity Panel comprising a total of 442 tetraploid wheat and wild progenitor accessions including durum landraces (n = 286), domesticated emmer (T...
November 16, 2023: Plant Genome
https://read.qxmd.com/read/37907924/decreased-hat1-expression-in-granulosa-cells-disturbs-oocyte-meiosis-during-mouse-ovarian-aging
#7
JOURNAL ARTICLE
Bichun Guo, Sainan Zhang, Shanshan Wang, Huidan Zhang, Junshun Fang, Nannan Kang, Xin Zhen, Yang Zhang, Jidong Zhou, Guijun Yan, Haixiang Sun, Lijun Ding, Chuanming Liu
BACKGROUND: With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged oocytes is far from understood. Histone acetyltransferase 1 (HAT1) has been reported to be essential for mammalian development and genome stability, and involved in multiple organ aging. Whether HAT1 is involved in ovarian aging and the detailed mechanisms remain to be elucidated...
October 31, 2023: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/37897558/the-role-of-acetylation-and-methylation-of-rat-hippocampal-histone-h3-in-the-mechanism-of-aluminum-induced-neurotoxicity
#8
JOURNAL ARTICLE
Jie Gao, Wei Liu, Jiaqi Liu, Niping Hao, Jing Pei, Lifeng Zhang
Aluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression of hippocampal HAT1 and G9a, and the protein expression level of H3K9 dimethylation (H3K9me2)...
October 28, 2023: Neurochemical Research
https://read.qxmd.com/read/37824391/comprehensive-characterization-of-hats-and-hdacs-in-human-cancers-reveals-their-role-in-immune-checkpoint-blockade
#9
JOURNAL ARTICLE
Rong Sun, Zike Chen, Xuanhao Qu, Jie Zhang, Lehan Liu, Zhuheng Zhong, Weibing Zhang, Yihui Fan
Histone acetylation that controlled by two mutually antagonistic enzyme families, histone acetyl transferases (HATs) and histone deacetylases (HDACs), as one of major epigenetic mechanisms controls transcription and its abnormal regulation was implicated in various aspects of cancer. However, the comprehensive understanding of HDACs and HATs in cancer is still lacking. Systematically analysis through 33 cancer types based on next-generation sequence data reveals heterogeneous expression pattern of HDACs and HATs across different cancer types...
2024: Critical Reviews in Eukaryotic Gene Expression
https://read.qxmd.com/read/37794134/hmgb1-set-hat1-complex-mediated-sash1-repression-drives-glycolysis-and-metastasis-in-lung-adenocarcinoma
#10
JOURNAL ARTICLE
Fan Kou, Lei Wu, Yu Zheng, Yeran Yi, Zhenyu Ji, Ziqi Huang, Shiwei Guo, Lili Yang
High-mobility group box 1 (HMGB1) can enhance the stability and accessibility of nucleus binding sites to nucleosomes and transcription factors. Recently, HMGB1 has been recognized as a positive regulator of tumor glutamine, and its overexpression has been correlated with tumorigenesis and cancer progression. However, functions and mechanisms of HMGB1 in regulation of glycolysis during cancer progression in lung adenocarcinoma (LUAD) is still unclear. Here, we found that intracellular HMGB1 was consistently upregulated in LUAD specimens, and positively relevant to tumor grade and poor survival...
October 4, 2023: Oncogene
https://read.qxmd.com/read/37763801/the-prognostic-and-therapeutic-role-of-histone-acetylation-modification-in-lihc-development-and-progression
#11
JOURNAL ARTICLE
Ji Gao, Sheng Han, Jian Gu, Chen Wu, Xiaoxin Mu
Background and Objectives: The modification of histone acetylation plays a vital role in regulating tumor occurrence and development, but the interaction between histone acetylation modulator genes and the liver hepatocellular carcinoma (LIHC) microenvironment, as well as immunotherapy, has not been investigated. Materials and Methods: Analysis of all statistical data was carried out using R software (Version 4.2.0) and the online tool Sangerbox. Comprehensive bioinformatics analysis, including signature construction and validation, functional analyses, immune and genomic features analyses, and immunotherapy prediction analyses, were performed to explore the prognostic and therapeutic role of histone acetylation modulator genes in LIHC development and progression...
September 18, 2023: Medicina
https://read.qxmd.com/read/37627511/korean-red-ginseng-attenuates-particulate-matter-induced-senescence-of-skin-keratinocytes
#12
JOURNAL ARTICLE
Kyoung Ah Kang, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Joo Mi Yi, Jin Won Hyun
Skin is a direct target of fine particulate matter (PM2.5 ), as it is constantly exposed. Herein, we investigate whether Korean red ginseng (KRG) can inhibit PM2.5 -induced senescence in skin keratinocytes. PM2.5 -treated human keratinocyte cell lines and normal human epidermal keratinocytes showed characteristics of cellular senescence, including flat and enlarged forms; however, KRG suppressed them in both cell types. Moreover, while cells exposed to PM2.5 showed a higher level of p16INK4A expression (a senescence inducer), KRG inhibited its expression...
July 28, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37538397/identification-and-characterization-of-putative-biomarkers-and-therapeutic-axis-in-glioblastoma-multiforme-microenvironment
#13
JOURNAL ARTICLE
Smita Kumari, Pravir Kumar
Non-cellular secretory components, including chemokines, cytokines, and growth factors in the tumor microenvironment, are often dysregulated, impacting tumorigenesis in Glioblastoma multiforme (GBM) microenvironment, where the prognostic significance of the current treatment remains unsatisfactory. Recent studies have demonstrated the potential of post-translational modifications (PTM) and their respective enzymes, such as acetylation and ubiquitination in GBM etiology through modulating signaling events. However, the relationship between non-cellular secretory components and post-translational modifications will create a research void in GBM therapeutics...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37513949/a-novel-acetylation-immune-subtyping-for-the-identification-of-a-bet-inhibitor-sensitive-subgroup-in-melanoma
#14
JOURNAL ARTICLE
Liuying Wang, Liuchao Zhang, Shuang Li, Lei Cao, Kang Li, Weiwei Zhao
BACKGROUND: There have been significant advancements in melanoma therapies. BET inhibitors (BETis) show promise in impairing melanoma growth. However, identifying BETi-sensitive melanoma subtypes is challenging. METHODS AND RESULTS: We analyzed 48 melanoma cell lines and 104 patients and identified two acetylation-immune subtypes (ALISs) in the cell lines and three ALISs in the patients. ALIS I, with high HAT1 and low KAT2A expression, showed a higher sensitivity to the BETi JQ-1 than ALIS II...
July 21, 2023: Pharmaceuticals
https://read.qxmd.com/read/37466313/hbv-confers-innate-immune-evasion-through-triggering-hat1-acetylation-of-h4k5-h4k12-mir-181a-5p-or-kpna2-cgas-sting-ifn-i-signaling
#15
JOURNAL ARTICLE
Lina Zhao, Hongfeng Yuan, Yufei Wang, Yu Geng, Haolin Yun, Wei Zheng, Ying Yuan, Pan Lv, Chunyu Hou, Huihui Zhang, Jiao Sun, Linlin Sun, Yuhong Suo, Shuai Wang, Ningning Zhang, Wei Lu, Guang Yang, Xiaodong Zhang
Viral immune evasion is crucial to the pathogenesis of hepatitis B virus (HBV) infection. However, the role of HBV in the modulation of innate immune evasion is poorly understood. A liver-specific histone acetyltransferase 1 (Hat1) knockout (KO) mouse model and HAT1 KO cell line were established. Immunohistochemistry staining, Western blot analysis, Southern blot analysis, Northern blot analysis, immunofluorescence assays, enzyme-linked immunosorbent assay, reverse transcription-quantitative polymerase chain reaction, and chromatin immunoprecipitation assays were performed in the livers of mouse models, primary human hepatocytes, HepG2-NTCP, and Huh7 and HepG2 cell lines...
July 2023: Journal of Medical Virology
https://read.qxmd.com/read/37297299/silver-nanoparticles-induced-changes-in-dna-methylation-and-histone-h3-methylation-in-a-mouse-model-of-breast-cancer
#16
JOURNAL ARTICLE
Kamil Brzóska, Barbara Sochanowicz, Małgorzata Szczygieł, Agnieszka Drzał, Martyna Śniegocka, Dominika Michalczyk-Wetula, Martyna Elas, Lucyna Kapka-Skrzypczak, Marcin Kruszewski
The importance of epigenetic changes as a measurable endpoint in nanotoxicological studies is getting more and more appreciated. In the present work, we analyzed the epigenetic effects induced by citrate- and PEG-coated 20 nm silver nanoparticles (AgNPs) in a model consisting of 4T1 breast cancer tumors in mice. Animals were administered with AgNPs intragastrically (1 mg/kg b.w. daily-total dose 14 mg/kg b.w.) or intravenously (administration twice with 1 mg/kg b.w.-total dose 2 mg/kg b.w.). We observed a significant decrease in 5-methylcytosine (5-mC) level in tumors from mice treated with citrate-coated AgNPs regardless of the route of administration...
June 2, 2023: Materials
https://read.qxmd.com/read/37277331/acl-and-hat1-form-a-nuclear-module-to-acetylate-histone-h4k5-and-promote-cell-proliferation
#17
JOURNAL ARTICLE
Qiutao Xu, Yaping Yue, Biao Liu, Zhengting Chen, Xuan Ma, Jing Wang, Yu Zhao, Dao-Xiu Zhou
Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear. Here we show that ACL subunit A2 (ACLA2) is present in nuclear condensates, is required for nuclear acetyl-CoA accumulation and acetylation of specific histone lysine residues, and interacts with Histone AcetylTransferase1 (HAT1) in rice. The rice HAT1 acetylates histone H4K5 and H4K16 and its activity on H4K5 requires ACLA2...
June 5, 2023: Nature Communications
https://read.qxmd.com/read/37107673/understanding-hat1-a-comprehensive-review-of-noncanonical-roles-and-connection-with-disease
#18
REVIEW
Miguel A Ortega, Diego De Leon-Oliva, Cielo Garcia-Montero, Oscar Fraile-Martinez, Diego Liviu Boaru, María Del Val Toledo Lobo, Ignacio García-Tuñón, Mar Royuela, Natalio García-Honduvilla, Julia Bujan, Luis G Guijarro, Melchor Alvarez-Mon, Miguel Ángel Alvarez-Mon
Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a lesser extent, H2A in the cytoplasm. However, 20 min after assembly, histones lose acetylation marks. Moreover, new noncanonical functions have been described for HAT1, revealing its complexity and complicating the understanding of its functions...
April 14, 2023: Genes
https://read.qxmd.com/read/37048148/hat1-landscape-of-biological-function-and-role-in-cancer
#19
REVIEW
Vincenza Capone, Laura Della Torre, Daniela Carannante, Mehrad Babaei, Lucia Altucci, Rosaria Benedetti, Vincenzo Carafa
Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone proteins. This epigenetic modification regulates transcriptional processes and protein activity, stability, and localization. Several studies highlight a specific role for HAT1 in regulating molecular pathways, which are altered in several pathologies, among which is cancer...
April 2, 2023: Cells
https://read.qxmd.com/read/37027002/acetyl-click-screening-platform-identifies-small-molecule-inhibitors-of-histone-acetyltransferase-1-hat1
#20
JOURNAL ARTICLE
Jitender D Gaddameedi, Tristan Chou, Benjamin S Geller, Amithvikram Rangarajan, Tarun A Swaminathan, Danielle Dixon, Katherine Long, Caiden J Golder, Van A Vuong, Selene Banuelos, Robert Greenhouse, Michael P Snyder, Andrew M Lipchik, Joshua J Gruber
HAT1 is a central regulator of chromatin synthesis that acetylates nascent histone H4. To ascertain whether targeting HAT1 is a viable anticancer treatment strategy, we sought to identify small-molecule inhibitors of HAT1 by developing a high-throughput HAT1 acetyl-click assay. Screening of small-molecule libraries led to the discovery of multiple riboflavin analogs that inhibited HAT1 enzymatic activity. Compounds were refined by synthesis and testing of over 70 analogs, which yielded structure-activity relationships...
April 7, 2023: Journal of Medicinal Chemistry
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