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https://www.readbyqxmd.com/read/27811920/acetylation-of-histone-h4-lysine-5-and-12-is-required-for-cenp-a-deposition-into-centromeres
#1
Wei-Hao Shang, Tetsuya Hori, Frederick G Westhorpe, Kristina M Godek, Atsushi Toyoda, Sadahiko Misu, Norikazu Monma, Kazuho Ikeo, Christopher W Carroll, Yasunari Takami, Asao Fujiyama, Hiroshi Kimura, Aaron F Straight, Tatsuo Fukagawa
Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primarily occur within the pre-nucleosomal CENP-A-H4-HJURP (CENP-A chaperone) complex, before centromere deposition. We show that H4K5ac and H4K12ac are mediated by the RbAp46/48-Hat1 complex and that RbAp48-deficient DT40 cells fail to recruit HJURP to centromeres and do not incorporate new CENP-A at centromeres...
November 4, 2016: Nature Communications
https://www.readbyqxmd.com/read/27793800/gene-expression-profiling-of-epigenetic-chromatin-modification-enzymes-and-histone-marks-by-cigarette-smoke-implications-for-copd-and-lung-cancer
#2
Isaac Kirubakaran Sundar, Irfan Rahman
Chromatin modifying enzymes mediate DNA methylation and histone modifications upon recruitment to specific target gene loci in response to various stimuli. The key enzymes that regulate chromatin accessibility for maintenance of modifications in DNA and histones, and for modulation of gene expression patterns in response to cigarette smoke (CS), are not known. We hypothesize that CS exposure alters the gene expression patterns of chromatin modifying enzymes, which then affects multiple downstream pathways involved in the response to CS...
October 28, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27618665/structural-insights-into-the-association-of-hif1-with-histones-h2a-h2b-dimer-and-h3-h4-tetramer
#3
Mengying Zhang, Hejun Liu, Yongxiang Gao, Zhongliang Zhu, Zijun Chen, Peiyi Zheng, Lu Xue, Jixi Li, Maikun Teng, Liwen Niu
Histone chaperones are critical for guiding specific post-transcriptional modifications of histones, safeguarding the histone deposition (or disassociation) of nucleosome (dis)assembly, and regulating chromatin structures to change gene activities. HAT1-interacting factor 1 (Hif1) has been reported to be an H3-H4 chaperone and to be involved in telomeric silencing and nucleosome (dis)assembly. However, the structural basis for the interaction of Hif1 with histones remains unknown. Here, we report the complex structure of Hif1 binding to H2A-H2B for uncovering the chaperone specificities of Hif1 on binding to both the H2A-H2B dimer and the H3-H4 tetramer...
October 4, 2016: Structure
https://www.readbyqxmd.com/read/27581081/effects-of-cytochalasin-b-on-dna-methylation-and-histone-modification-in-parthenogenetically-activated-porcine-embryos
#4
Xiaoxiao Hou, Jun Liu, Zhiren Zhang, Yanhui Zhai, Yutian Wang, Zhengzhu Wang, Bo Tang, Xueming Zhang, Liguang Sun, Ziyi Li
DNA methylation and histone modification play important roles in the development of mammalian embryos. Cytochalasin B (CB) is an actin polymerization inhibitor that can significantly affect cell activity and is often used in studies concerning cytology. In recent years, CB is also commonly being used in in vitro experiments on mammalian embryos, but few studies have addressed the effect of CB on the epigenetic modification of embryonic development, and the mechanism underlying this process is also unknown. This study was conducted to investigate the effects of CB on DNA methylation and histone modification in the development of parthenogenetically activated porcine embryos...
November 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27501872/the-effect-of-ovine-oocyte-vitrification-on-expression-of-subset-of-genes-involved-in-epigenetic-modifications-during-oocyte-maturation-and-early-embryo-development
#5
Abolfazl Shirazi, Mohammad Mahdi Naderi, Hossein Hassanpour, Mahbobeh Heidari, Sara Borjian, Ali Sarvari, Mohammad Mehdi Akhondi
Apart from ultrastructural damages in oocytes subjected to cryopreservation procedures, little is known about the status of epigenetic modification and chromatin remodeling in vitrified oocytes. In present study, the expression patterns of eight genes involved in epigenetic modification (HAT1, HDAC1, SUV39H1, DNMT1, and DNMT3b), chromatin remodeling (HMGN3a and SMARCAL1), and transcription (STAT3), were investigated in fresh and vitrified germinal vesicle and metaphase II oocytes and their resulting embryos at 2 to 7 cells, 8 to 16 cells, morula, and blastocyst stages...
July 15, 2016: Theriogenology
https://www.readbyqxmd.com/read/27495086/genetic-signatures-of-heroin-addiction
#6
Shaw-Ji Chen, Ding-Lieh Liao, Tsu-Wang Shen, Hsin-Chou Yang, Kuang-Chi Chen, Chia-Hsiang Chen
Heroin addiction is a complex psychiatric disorder with a chronic course and a high relapse rate, which results from the interaction between genetic and environmental factors. Heroin addiction has a substantial heritability in its etiology; hence, identification of individuals with a high genetic propensity to heroin addiction may help prevent the occurrence and relapse of heroin addiction and its complications. The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27400176/a-b-type-histone-acetyltransferase-hat1-regulates-secondary-metabolism-conidiation-and-cell-wall-integrity-in-the-taxol-producing-fungus-pestalotiopsis-microspora
#7
Qian Zhang, Longfei Chen, Xi Yu, Heng Liu, Oren Akhberdi, Jiao Pan, Xudong Zhu
In filamentous fungi, many gene clusters for the biosynthesis of secondary metabolites often stay silent under laboratory culture conditions because of the absence of communication with its natural environment. Epigenetic processes have been demonstrated to be critical in the expression of the genes or gene clusters. Here, we report the identification of a B-type histone acetyltransferase, Hat1, and demonstrate its significant roles in secondary metabolism, conidiation, and the cell wall integrity in the fungus Pestalotiopsis microspora...
December 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27328697/role-of-transcription-factor-hat1-in-modulating-arabidopsis-thaliana-response-to-cucumber-mosaic-virus
#8
Li-Juan Zou, Xing-Guang Deng, Xue-Ying Han, Wen-Rong Tan, Li-Jun Zhu, De-Hui Xi, Da-Wei Zhang, Hong-Hui Lin
Arabidopsis thaliana homeodomain-leucine zipper protein 1 (HAT1) belongs to the homeodomain-leucine zipper (HD-Zip) family class II that plays important roles in plant growth and development as a transcription factor. To elucidate further the role of HD-Zip II transcription factors in plant defense, the A. thaliana hat1, hat1hat3 and hat1hat2hat3 mutants and HAT1 overexpression plants (HAT1OX) were challenged with Cucumber mosaic virus (CMV). HAT1OX displayed more susceptibility, while loss-of-function mutants of HAT1 exhibited less susceptibility to CMV infection...
September 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/27259240/interaction-of-dna-demethylase-and-histone-methyltransferase-upregulates-nrf2-in-5-fluorouracil-resistant-colon-cancer-cells
#9
Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Hee Kyoung Kang, Weon Young Chang, Young Sam Keum, Jin Won Hyun
We recently reported that DNA demethylase ten-eleven translocation 1 (TET1) upregulates nuclear factor erythroid 2-related factor 2 (Nrf2) in 5-fluorouracil-resistant colon cancer cells (SNUC5/5-FUR). In the present study, we examined the effect of histone modifications on Nrf2 transcriptional activation. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) were respectively decreased and increased in SNUC5/5-FUR cells as compared to non-resistant parent cells. Mixed-lineage leukemia (MLL), a histone methyltransferase, was upregulated, leading to increased trimethylation of histone H3 lysine 4, while G9a was downregulated, leading to decreased dimethylation of histone H3 lysine 9...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27247266/the-c-terminal-rgg-domain-of-human-lsm4-promotes-processing-body-formation-stimulated-by-arginine-dimethylation
#10
Marcos Arribas-Layton, Jaclyn Dennis, Eric J Bennett, Christian K Damgaard, Jens Lykke-Andersen
Processing bodies (PBs) are conserved cytoplasmic aggregations of translationally repressed mRNAs assembled with mRNA decay factors. The aggregation of mRNA-protein (mRNP) complexes into PBs involves interactions between low-complexity regions of protein components of the mRNPs. In Saccharomyces cerevisiae, the carboxy (C)-terminal Q/N-rich domain of the Lsm4 subunit of the Lsm1-7 complex plays an important role in PB formation, but the C-terminal domain of Lsm4 in most eukaryotes is an RGG domain rather than Q/N rich...
September 1, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26654953/mir-486-regulates-cholesterol-efflux-by-targeting-hat1
#11
Dan Liu, Min Zhang, Wei Xie, Gang Lan, Hai-Peng Cheng, Duo Gong, Chong Huang, Yun-Cheng Lv, Feng Yao, Yu-Lin Tan, Liang Li, Xi-Long Zheng, Chao-Ke Tang
RATIONALE: Excessive cholesterol accumulation in macrophages is a major factor of foam cell formation and development of atherosclerosis. Previous studies suggested that miR-486 plays an important role in cardiovascular diseases, but the underlying mechanism is still unknown. OBJECTIVE: The purpose of this study is to determine whether miR-486 regulates ATP-binding cassette transporter A1 (ABCA1) mediated cholesterol efflux, and also explore the underlying mechanism...
April 8, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26651296/in-vitro-maturation-affects-chromosome-segregation-spindle-morphology-and-acetylation-of-lysine-16-on-histone-h4-in-horse-oocytes
#12
Federica Franciosi, Ghylene Goudet, Irene Tessaro, Pascal Papillier, Rozenn Dalbies-Tran, Fabrice Reigner, Stefan Deleuze, Cecile Douet, Ileana Miclea, Valentina Lodde, Alberto M Luciano
Implantation failure and genetic developmental disabilities in mammals are caused by errors in chromosome segregation originating mainly in the oocyte during meiosis I. Some conditions, like maternal ageing or in vitro maturation (IVM), increase the incidence of oocyte aneuploidy. Here oocytes from adult mares were used to investigate oocyte maturation in a monovulatory species. Experiments were conducted to compare: (1) the incidence of aneuploidy, (2) the morphology of the spindle, (3) the acetylation of lysine 16 on histone H4 (H4K16) and (4) the relative amount of histone acetyltransferase 1 (HAT1), K(lysine) acetyltransferase 8 (KAT8, also known as MYST1), histone deacetylase 1 (HDAC1) and NAD-dependent protein deacetylase sirtuin 1 (SIRT1) mRNA in metaphase II stage oocytes that were in vitro matured or collected from peri-ovulatory follicles...
December 14, 2015: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/26640654/identification-of-acetyltransferase-genes-hat1-and-kat8-regulating-hbv-replication-by-rnai-screening
#13
Hui Wang, KeHui Liu, Bernard A M Fang, HaiQing Wu, FengDi Li, XiaoGang Xiang, WeiLiang Tang, GangDe Zhao, LanYi Lin, Shisan Bao, Qing Xie
BACKGROUND: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. The regulatory mechanism of HBV replication by acetyltransferase is thus far not well understood, but human acetyltransferase has been reported as being involved in the regulation of HBV replication. RESULTS: Depletion of KAT8 or HAT1 via RNA interference (RNAi) markedly down-regulated HBV-DNA and pgRNA levels in HepG2...
2015: Cell & Bioscience
https://www.readbyqxmd.com/read/26586808/a-novel-role-for-the-histone-acetyltransferase-hat1-in-the-cenp-a-cid-assembly-pathway-in-drosophila-melanogaster
#14
Mark Boltengagen, Anming Huang, Anastasiya Boltengagen, Lukas Trixl, Herbert Lindner, Leopold Kremser, Martin Offterdinger, Alexandra Lusser
The incorporation of CENP-A into centromeric chromatin is an essential prerequisite for kinetochore formation. Yet, the molecular mechanisms governing this process are surprisingly divergent in different organisms. While CENP-A loading mechanisms have been studied in some detail in mammals, there are still large gaps to our understanding of CENP-A/Cid loading pathways in Drosophila. Here, we report on the characterization and delineation of at least three different CENP-A preloading complexes in Drosophila...
March 18, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/26522166/dissecting-the-molecular-roles-of-histone-chaperones-in-histone-acetylation-by-type-b-histone-acetyltransferases-hat-b
#15
Allison Haigney, M Daniel Ricketts, Ronen Marmorstein
The HAT-B enzyme complex is responsible for acetylating newly synthesized histone H4 on lysines K5 and K12. HAT-B is a multisubunit complex composed of the histone acetyltransferase 1 (Hat1) catalytic subunit and the Hat2 (rbap46) histone chaperone. Hat1 is predominantly localized in the nucleus as a member of a trimeric NuB4 complex containing Hat1, Hat2, and a histone H3-H4 specific histone chaperone called Hif1 (NASP). In addition to Hif1 and Hat2, Hat1 interacts with Asf1 (anti-silencing function 1), a histone chaperone that has been reported to be involved in both replication-dependent and -independent chromatin assembly...
December 18, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26473952/the-candida-albicans-histone-acetyltransferase-hat1-regulates-stress-resistance-and-virulence-via-distinct-chromatin-assembly-pathways
#16
Michael Tscherner, Florian Zwolanek, Sabrina Jenull, Fritz J Sedlazeck, Andriy Petryshyn, Ingrid E Frohner, John Mavrianos, Neeraj Chauhan, Arndt von Haeseler, Karl Kuchler
Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a novel role for the chromatin assembly-associated histone acetyltransferase complex NuB4 in regulating oxidative stress resistance, antifungal drug tolerance and virulence in C. albicans. Strikingly, depletion of the NuB4 catalytic subunit, the histone acetyltransferase Hat1, markedly increases resistance to oxidative stress and tolerance to azole antifungals...
October 2015: PLoS Pathogens
https://www.readbyqxmd.com/read/26218133/curcumin-mediated-hdac-inhibition-suppresses-the-dna-damage-response-and-contributes-to-increased-dna-damage-sensitivity
#17
Shu-Huei Wang, Pei-Ya Lin, Ya-Chen Chiu, Ju-Sui Huang, Yi-Tsen Kuo, Jen-Chine Wu, Chin-Chuan Chen
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments. In this study, we show that curcumin, a plant polyphenol, sensitizes budding yeast to DNA damage by counteracting the DNA damage response. Following DNA damage, the Mec1-dependent DNA damage checkpoint is inactivated and Rad52 recombinase is degraded by curcumin, which results in deficiencies in double-stand break repair...
2015: PloS One
https://www.readbyqxmd.com/read/26068219/epigenetic-modification-agents-improve-gene-specific-methylation-reprogramming-in-porcine-cloned-embryos
#18
Yanjun Huan, Zhanfeng Wu, Jiguang Zhang, Jiang Zhu, Zhonghua Liu, Xuexiong Song
Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Epigenetic modification agents can improve genomic methylation reprogramming and the development of cloned embryos, however, the effect of epigenetic modification agents on gene-specific methylation reprogramming remains poorly studied. Here, we investigated DNA methylation reprogramming of pluripotency (Oct4) and tissue specific (Thy1) genes during early embryo development in pigs. In this study, we found that compared with in vitro fertilized counterparts, cloned embryos displayed the disrupted patterns of Oct4 demethylation and Thy1 remethylation...
2015: PloS One
https://www.readbyqxmd.com/read/26035741/effects-of-scriptaid-on-the-histone-acetylation-dna-methylation-and-development-of-buffalo-somatic-cell-nuclear-transfer-embryos
#19
Hongliang Sun, Fenghua Lu, Peng Zhu, Xiaohua Liu, Mingming Tian, Chan Luo, Qiuyan Ruan, Ziyun Ruan, Qingyou Liu, Jianrong Jiang, Yingming Wei, Deshun Shi
The present study was undertaken to examine the effect of Scriptaid treatment on histone acetylation, DNA methylation, expression of genes related to histone acetylation, and development of buffalo somatic cell nuclear transfer (SCNT) embryos. Treatment of buffalo SCNT embryos with 500 nM Scriptaid for 24 h resulted in a significant increase in the blastocyst formation rate (28.2% vs. 13.6%, p<0.05). Meanwhile, treatment of buffalo SCNT embryos with Scriptaid also resulted in higher acetylation levels of H3K18 and lower methylation levels of global DNA at the blastocyst stage, which was similar to fertilized counterparts...
October 2015: Cellular Reprogramming
https://www.readbyqxmd.com/read/25865065/the-acetyltransferase-hat1-moderates-the-nf-%C3%AE%C2%BAb-response-by-regulating-the-transcription-factor-plzf
#20
Anthony J Sadler, Bandar A Suliman, Liang Yu, Xiangliang Yuan, Die Wang, Aaron T Irving, Soroush T Sarvestani, Ashish Banerjee, Ashley S Mansell, Jun-Ping Liu, Steve Gerondakis, Bryan R G Williams, Dakang Xu
To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be shown to rival phosphorylation in its importance in mediating cellular responses. However, limited instances have been identified. Here we show that signalling from Toll-like or TNF-α receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF...
2015: Nature Communications
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