Lina Zhao, Hongfeng Yuan, Yufei Wang, Yu Geng, Haolin Yun, Wei Zheng, Ying Yuan, Pan Lv, Chunyu Hou, Huihui Zhang, Jiao Sun, Linlin Sun, Yuhong Suo, Shuai Wang, Ningning Zhang, Wei Lu, Guang Yang, Xiaodong Zhang
Viral immune evasion is crucial to the pathogenesis of hepatitis B virus (HBV) infection. However, the role of HBV in the modulation of innate immune evasion is poorly understood. A liver-specific histone acetyltransferase 1 (Hat1) knockout (KO) mouse model and HAT1 KO cell line were established. Immunohistochemistry staining, Western blot analysis, Southern blot analysis, Northern blot analysis, immunofluorescence assays, enzyme-linked immunosorbent assay, reverse transcription-quantitative polymerase chain reaction, and chromatin immunoprecipitation assays were performed in the livers of mouse models, primary human hepatocytes, HepG2-NTCP, and Huh7 and HepG2 cell lines...
July 2023: Journal of Medical Virology