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Salicylate toxicity

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https://www.readbyqxmd.com/read/28072512/a-high-performance-hybrid-bismuth-carbon-nanotube-based-contrast-agent-for-x-ray-ct-imaging
#1
Mayra Hernández-Rivera, Ish Kumar, Stephen Y Cho, Benjamin Y Cheong, Merlyn X Pulikkathara, Sakineh E Moghaddam, Kenton Herbert Whitmire, Lon J Wilson
Carbon nanotubes (CNTs) have been used for a plethora of biomedical applications including their use as delivery vehi-cles for drugs, imaging agents, proteins, DNA, and other materials. Here we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultra-short single-walled carbon nanotubes (20-80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today, due to its high X-ray attenuation capability and its low toxicity, which make bismuth a more promising element for new CT CA design...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056938/hepatoprotective-effect-of-the-solvent-extracts-of-viola-canescens-wall-ex-roxb-against-ccl4-induced-toxicity-through-antioxidant-and-membrane-stabilizing-activity
#2
Abdullah, Mir Azam Khan, Waqar Ahmad, Manzoor Ahmad, Mohammad Nisar
BACKGROUND: Viola canescens Wall. ex. Roxb. exhibits analgesic, antimalarial and antispasmodic activities. It is used folklorically for the treatment of liver diseases, hypertension, malaria and cancer. The current study investigates phytochemical constituents, antioxidant and hepatoprotective activity of solvent extracts of whole plant of Viola canescens. METHODS: Phytochemicals, acute toxicity study and antioxidant activity of Viola canescens methanolic extract (VCME), ethyl acetate fraction (EAF), and partially purified EAF (90% EAF and combination of 80% EAF + 20% methanol fraction (EAF + Me) was carried out...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28036129/synthesis-and-in-vitro-bioactivity-evaluation-of-new-galactose-and-fructose-ester-derivatives-of-5-aminosalicylic-acid
#3
Samira Yousefi, Saadi Bayat, Mohd Basyaruddin Abdul Rahman, Zalikha Ibrahim, Emilia Abdulmalek
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of galactose and fructose esters of 5-ASA was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two Gram-negative and two Gram-positive species of bacteria, with a notable effect observed against Staphylococcus aureus and Escherichia coli in comparisons with the 5-ASA...
December 30, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27979084/recent-advances-on-determination-of-milk-adulterants
#4
REVIEW
Carina F Nascimento, Poliana M Santos, Edenir Rodrigues Pereira-Filho, Fábio R P Rocha
Milk adulteration is a current fraudulent practice to mask the quality parameters (e.g. protein and fat content) and increase the product shelf life. Milk adulteration includes addition of toxic substances, such as formaldehyde, hydrogen peroxide, hypochlorite, dichromate, salicylic acid, melamine, and urea. In order to assure the food safety and avoid health risks to consumers, novel analytical procedures have been proposed for detection of these adulterants. The innovations encompass sample pretreatment and improved detection and data processing, including chemometric tools...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27951421/exogenous-salicylic-acid-alleviates-the-toxicity-of-chlorpyrifos-in-wheat-plants-triticum-aestivum
#5
Caixia Wang, Qingming Zhang
The role of exogenous salicylic acid (SA) in protecting wheat plants (Triticum aestivum) from contamination by the insecticide chlorpyrifos was investigated in this study. The wheat plants were grown in soils with different concentrations (5, 10, 20, and 40mgkg(-1)) of chlorpyrifos. When the third leaf emerged, the wheat leaves were sprayed with 1, 2, 4, 8, and 16mgL(-1) of SA once a day for 6 days. The results showed that wheat exposed to higher concentrations of chlorpyrifos (≥20mgkg(-1)) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX)...
March 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27931000/thorium-impact-on-tobacco-root-transcriptome
#6
Kateřina Mazari, Přemysl Landa, Sylva Přerostová, Karel Müller, Radomíra Vaňková, Petr Soudek, Tomáš Vaněk
Thorium is natural actinide metal with potential use in nuclear energetics. Contamination by thorium, originated from mining activities or spills, represents environmental risk due to its radioactivity and chemical toxicity. A promising approach for cleaning of contaminated areas is phytoremediation, which need to be based, however, on detail understanding of the thorium effects on plants. In this study we investigated transcriptomic response of tobacco roots exposed to 200μM thorium for one week. Thorium application resulted in up-regulation of 152 and down-regulation of 100 genes (p-value <0...
March 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27867390/the-mechanisms-of-maize-resistance-to-fusarium-verticillioides-by-comprehensive-analysis-of-rna-seq-data
#7
Yanping Wang, Zijian Zhou, Jingyang Gao, Yabin Wu, Zongliang Xia, Huiyong Zhang, Jianyu Wu
Fusarium verticillioides is the most commonly reported fungal species responsible for ear rot of maize which substantially reduces grain yield. It also results in a substantial accumulation of mycotoxins that give rise to toxic response when ingested by animals and humans. For inefficient control by chemical and agronomic measures, it thus becomes more desirable to select more resistant varieties. However, the molecular mechanisms underlying the infection process remain poorly understood, which hampers the application of quantitative resistance in breeding programs...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27834107/a-critical-review-of-the-literature-to-conduct-a-toxicity-assessment-for-oral-exposure-to-methyl-salicylate
#8
Tracy Greene, Sarah Rogers, Allison Franzen, Robinan Gentry
Methyl salicylate is the predominant constituent of oil of wintergreen and is used as a pesticide, a denaturant, an external analgesic, a fragrance ingredient, and a flavoring agent in products such as chewing gum, baked goods, syrups, candy, beverages, ice cream, and tobacco products; and it occurs naturally in some vegetables and berries. Methyl salicylate is of interest to the tobacco industry as oil of wintergreen is used as a flavorant in tobacco products. The purpose of this investigation was to conduct a critical review of the available literature for oral exposure to methyl salicylate, incorporating an analysis of the quality of the studies available and the current understanding of the mode of action...
November 11, 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27811003/nitrite-is-the-driver-phytohormones-are-modulators-while-no-and-h2o2-act-as-promoters-of-no2-induced-cell-death
#9
Dörte Kasten, Axel Mithöfer, Elisabeth Georgii, Hans Lang, Jörg Durner, Frank Gaupels
This study aimed to understand the molecular mechanisms of nitrogen dioxide (NO2)-induced toxicity and cell death in plants. Exposure of Arabidopsis to high concentrations of NO2 induced cell death in a dose-dependent manner. No leaf symptoms were visible after fumigation for 1 h with 10 parts per million (ppm) NO2 However, 20 ppm NO2 caused necrotic lesion formation and 30 ppm NO2 complete leaf collapse, which had already started during the 1 h fumigation period. NO2 fumigation resulted in a massive accumulation of nitrite and in protein modifications by S-nitrosylation and tyrosine nitration...
November 2, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27776888/polyfluorinated-salicylic-acid-derivatives-as-analogs-of-known-drugs-synthesis-molecular-docking-and-biological-evaluation
#10
E V Shchegol'kov, I V Shchur, Ya V Burgart, V I Saloutin, A N Trefilova, G A Ljushina, S Yu Solodnikov, L N Markova, V V Maslova, O P Krasnykh, S S Borisevich, S L Khursan
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
January 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27750140/seasonal-changes-in-antioxidative-oxidative-profile-of-mining-and-non-mining-populations-of-syrian-beancaper-as-determined-by-soil-conditions
#11
Antonio López-Orenes, María C Bueso, Héctor M Conesa, Antonio A Calderón, María A Ferrer
Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed. Successful plant establishment in multi-polluted soils can be hampered not only by HMM toxicities, but also by soil nutrient deficiencies and the co-occurrence of abiotic stresses. Some plant species are able to thrive under these multi-stress scenarios often linked to marked fluctuations in environmental factors. This study aimed to investigate the metabolic adjustments involved in Zygophyllum fabago acclimative responses to conditions prevailing in HMM-enriched mine-tailings piles, during Mediterranean spring and summer...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27749632/delayed-salicylate-toxicity-in-a-17-year-old-girl-with-initially-undetectable-salicylate-concentration-3-9-hours-after-ingestion
#12
Gillian A Beauchamp, Robert G Hendrickson
We report the case of a 17-year-old girl with a 126-mg/kg nonenteric coated aspirin ingestion with nontoxic salicylate concentrations at 1.5 and 3.9 hours postingestion, who developed tinnitus and vomiting an estimated 8 hours postingestion, and who was subsequently found to have a toxic salicylate concentration at 22.7 hours postingestion. This case, as well as previous cases of delayed aspirin therapy, may prompt providers to consider educating patients and their care providers regarding the need to return for further testing if symptoms, such as vomiting or tinnitus, develop after an aspirin ingestion...
September 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27742359/fumigant-and-contact-toxicity-of-22-wooden-essential-oils-and-their-major-components-against-drosophila-suzukii-diptera-drosophilidae
#13
Junheon Kim, Miyeon Jang, Eunsik Shin, Jeongmin Kim, Si Hyeock Lee, Chung Gyoo Park
Fumigant and contact toxicities of 22 plant essential oils (EOs) from 14 families and their constituents against the adult spotted wing drosophila (SWD), Drosophila suzukii were examined. Analyses by GC, GC-MS, and NMR led to the identification of 2, 16, 13, 4, 6, 9, and 10 compounds from Gaultheria fragrantissima, Croton anistatum, Illicium verum, Liquidamabar orientalis, Cinnamomum cassia, Rosa damasena, and Santalum album, respectively. In fumigant toxicity test, G. fragrantissima, C. anistatum, and I. verum exhibited 100, 93...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27718063/strategies-of-chemical-anti-predator-defences-in-leaf-beetles-is-sequestration-of-plant-toxins-less-costly-than-de-novo-synthesis
#14
Elena L Zvereva, Vitali Zverev, Oksana Y Kruglova, Mikhail V Kozlov
The evolution of defensive traits is driven both by benefits gained from protection against enemies and by costs of defence production. We tested the hypothesis that specialisation of herbivores on toxic host plants, accompanied by the ability to acquire plant defensive compounds for herbivore defence, is favoured by the lower costs of sequestration compared to de novo synthesis of defensive compounds. We measured physiological costs of chemical defence as a reduction in larval performance in response to repeated removal of secretions (simulating predator attack) and compared these costs between five species synthesising defences de novo and three species sequestering salicylic glucosides (SGs) from their host plants...
October 7, 2016: Oecologia
https://www.readbyqxmd.com/read/27676096/evaluation-of-chromane-based-bryostatin-analogues-prepared-via-hydrogen-mediated-c-c-bond-formation-potency-does-not-confer-bryostatin-like-biology
#15
John M Ketcham, Ivan Volchkov, Te-Yu Chen, Peter M Blumberg, Noemi Kedei, Nancy E Lewin, Michael J Krische
The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2-WN-7 and the previously reported salicylate-based analogue WN-8 are described. Analogues WN-2-WN-7 are prepared through convergent assembly of the chromane-containing fragment B-I with the "binding domain" fragment A-I or its C26-des-methyl congener, fragment A-II. The synthesis of fragment B-I features enantioselective double C-H allylation of 1,3-propanediol to form the C2-symmetric diol 3 and Heck cyclization of bromo-diene 5 to form the chromane core...
October 12, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27667541/production-and-characterization-of-polycaprolactone-hyaluronic-acid-chitosan-zein-electrospun-bilayer-nanofibrous-membrane-for-tissue-regeneration
#16
Daniela R Figueira, Sónia P Miguel, Kevin D de Sá, Ilídio J Correia
A bilayered electrospun membrane was produced in this study, using the electrospinning technique, to be applied as a skin substitute. The upper layer of the membrane was comprised by hyaluronic acid and polycaprolactone in order to provide mechanical support and also to act as a physical barrier against external threats. Chitosan and zein were used to produce the bottom layer that was loaded with salicylic acid, in order to confer anti-inflammatory and antimicrobial activity to this layer. The physicochemical properties of the membranes were determined and the obtained results showed that the produced electrospun membrane display an ideal porosity, appropriate mechanical properties, controlled water loss and a suitable salicylic acid release profile...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27581631/different-spectrophotometric-and-tlc-densitometric-methods-for-determination-of-mesalazine-in-presence-of-its-two-toxic-impurities
#17
Martha Moheb Morcoss, Nada Sayed Abdelwahab, Nouruddin Wagieh Ali, Mohammed Taha Elsaady
Two selective spectrophotometric and TLC-densitometric methods were developed for determination of mesalazine (ME) and its two toxic impurities, 4-amino phenol (4AP) and salicylic acid (SA) without preliminary separation. The proposed methods are: ratio difference in the subtracted spectra (RDSS) {Method 1}, area under the curve (AUC) {Method 2} and TLC-densitometric {Method 3}. In method {1} combination of measuring the amplitude of the constant at 350 nm (using standard spectrum of 10 µg/mL ME as a divisor) and ratio difference in the subtracted ratio spectrum for determination of 4AP and SA using the ratio difference at 221...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27580341/structural-and-kinetic-properties-of-the-aldehyde-dehydrogenase-nahf-a-broad-substrate-specificity-enzyme-for-aldehyde-oxidation
#18
Juliana B Coitinho, Mozart S Pereira, Débora M A Costa, Samuel L Guimarães, Simara S Araújo, Alvan C Hengge, Tiago A S Brandão, Ronaldo A P Nagem
The salicylaldehyde dehydrogenase (NahF) catalyzes the oxidation of salicylaldehyde to salicylate using NAD(+) as a cofactor, the last reaction of the upper degradation pathway of naphthalene in Pseudomonas putida G7. The naphthalene is an abundant and toxic compound in oil and has been used as a model for bioremediation studies. The steady-state kinetic parameters for oxidation of aliphatic or aromatic aldehydes catalyzed by 6xHis-NahF are presented. The 6xHis-NahF catalyzes the oxidation of aromatic aldehydes with large kcat/Km values close to 10(6) M(-1) s(-1)...
September 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27575042/combined-ability-of-chromium-cr-tolerant-plant-growth-promoting-bacteria-pgpb-and-salicylic-acid-sa-in-attenuation-of-chromium-stress-in-maize-plants
#19
Faisal Islam, Tahira Yasmeen, Muhammad Saleem Arif, Muhammad Riaz, Sher Muhammad Shahzad, Qaiser Imran, Irfan Ali
Heavy metal contamination of agricultural soil has become a serious global problem. This study was aimed to evaluate the effects of two chromium (Cr) tolerant plant growth promoting bacteria (PGPB) in combination with salicylic acid (SA) on plant growth, physiological, biochemical responses and heavy metal uptake under Cr contamination. A pot experiment (autoclaved sand as growing medium) was performed using maize (Zea mays L.) as a test crop under controlled conditions. Cr toxicity significantly reduced plant growth, photosynthetic pigment, carbohydrates metabolism and increased H2O2, MDA, relative membrane permeability, proline and Cr contents in maize leaves...
November 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27553001/phytotoxicity-of-15-common-pharmaceuticals-on-the-germination-of-lactuca-sativa-and-photosynthesis-of-chlamydomonas-reinhardtii
#20
Ma Rosa Pino, Selene Muñiz, Jonatan Val, Enrique Navarro
Pharmaceuticals reach terrestrial environments through the application of treated wastewaters and biosolids to agricultural soils. We have investigated the toxicity of 15 common pharmaceuticals, classified as nonsteroidal anti-inflammatory drugs (NSAIDs), blood lipid-lowering agents, β-blockers and antibiotics, in two photosynthetic organisms. Twelve pharmaceuticals caused inhibitory effects on the radicle and hypocotyl elongation of Lactuca sativa seeds. The EC50 values obtained were in the range of 170-5656 mg L(-1) in the case of the radicle and 188-4558 mg L(-1) for the hypocotyl...
August 24, 2016: Environmental Science and Pollution Research International
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