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Salicylate toxicity

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https://www.readbyqxmd.com/read/28300791/anacardic-acid-constituents-from-cashew-nut-shell-liquid-nmr-characterization-and-the-effect-of-unsaturation-on-its-biological-activities
#1
Selene M Morais, Katherine A Silva, Halisson Araujo, Icaro G P Vieira, Daniela R Alves, Raquel O S Fontenelle, Artur M S Silva
Anacardic acids are the main constituents of natural cashew nut shell liquid (CNSL), obtained via the extraction of cashew shells with hexane at room temperature. This raw material presents high technological potential due to its various biological properties. The main components of CNSL are the anacardic acids, salicylic acid derivatives presenting a side chain of fifteen carbon atoms with different degrees of unsaturation (monoene-15:1, diene-15:2, and triene-15:3). Each constituent was isolated by column chromatography using silica gel impregnated with silver nitrate...
March 16, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28257519/strategy-of-pseudomonas-pseudoalcaligenes-c70-for-effective-degradation-of-phenol-and-salicylate
#2
Merike Jõesaar, Signe Viggor, Eeva Heinaru, Eve Naanuri, Maris Mehike, Ivo Leito, Ain Heinaru
Phenol- and naphthalene-degrading indigenous Pseudomonas pseudoalcaligenes strain C70 has great potential for the bioremediation of polluted areas. It harbours two chromosomally located catechol meta pathways, one of which is structurally and phylogenetically very similar to the Pseudomonas sp. CF600 dmp operon and the other to the P. stutzeri AN10 nah lower operon. The key enzymes of the catechol meta pathway, catechol 2,3-dioxygenase (C23O) from strain C70, PheB and NahH, have an amino acid identity of 85%...
2017: PloS One
https://www.readbyqxmd.com/read/28250583/imperative-roles-of-salicylic-acid-and-nitric-oxide-in-improving-salinity-tolerance-in-pisum-sativum-l
#3
Shrishti Yadu, Teman Lal Dewangan, Vibhuti Chandrakar, S Keshavkant
This study was undertaken to scrutinize efficacy of salicylic acid (SA) and/or sodium nitroprusside [SNP, source of nitric oxide (NO)] to mitigate injury symptoms of saline stress in Pisum sativum L. Exposure to sodium chloride (NaCl) was found to be injurious to germinating P. sativum L. (var. Shubhra IM-9101) and a direct correlation between severity of toxicity and NaCl-concentrations could be discernible. Both SA and NO serves as signal molecules in plant stress responses, and play crucial roles in key regulatory pathways of growth, development and metabolism...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28224155/metabonomic-analysis-of-quercetin-against-the-toxicity-of-acrylamide-in-rat-urine
#4
Wei Bao, Can Cao, Siqi Li, Lu Bo, Meiyan Zhang, Xiujuan Zhao, Ying Liu, Changhao Sun
This research aims to determine whether quercetin has protective effects against the toxicity of acrylamide (AA) using metabonomic technology. Randomly, the rats were assigned into a control group, AA treatment group, quercetin treatment group and quercetin plus AA treatment group. Quercetin and AA were administered to rats daily via gavage and drinking water for 16 weeks, respectively. To detect the metabonomic profiles of urine, ultra-performance liquid chromatography/mass spectrometry was used. A total of 15 metabolites, including biomarkers of AA exposure (GAMA, AAMA, and iso-AAMA) and quercetin exposure (quercetin and isorhamnetin), were identified...
February 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28158885/breaking-bad-delirium-methamphetamine-and-boric-acid-toxicity-with-hallucinations-and-pseudosepsis
#5
Kayla Johnson, Joanna L Stollings, E Wesley Ely
OBJECTIVES: A 30-year-old patient presented with hallucinations and profound shock. He was initially misdiagnosed as having severe sepsis; once ingestions were considered, he was diagnosed as potentially having arsenic toxicity. SUMMARY: The clinical story reveals many instructional lessons that could aid in the evaluation and management of future patients. This man presented with large amounts of blue crystals around his nose and lips from inhaling and eating boric acid (an ant poison) so he could, as he put it, kill the ants "pouring into my mouth and nose and up into my brain...
February 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28115148/diclofop-methyl-affects-microbial-rhizosphere-community-and-induces-systemic-acquired-resistance-in-rice
#6
Si Chen, Xingxing Li, Michel Lavoie, Yujian Jin, Jiahui Xu, Zhengwei Fu, Haifeng Qian
Diclofop-methyl (DM), a widely used herbicide in food crops, may partly contaminate the soil surface of natural ecosystems in agricultural area and exert toxic effects at low dose to nontarget plants. Even though rhizosphere microorganisms strongly interact with root cells, little is known regarding their potential modulating effect on herbicide toxicity in plants. Here we exposed rice seedlings (Xiushui 63) to 100μg/L DM for 2 to 8days and studied the effects of DM on rice rhizosphere microorganisms, rice systemic acquired resistance (SAR) and rice-microorganisms interactions...
January 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28072512/high-performance-hybrid-bismuth-carbon-nanotube-based-contrast-agent-for-x-ray-ct-imaging
#7
Mayra Hernández-Rivera, Ish Kumar, Stephen Y Cho, Benjamin Y Cheong, Merlyn X Pulikkathara, Sakineh E Moghaddam, Kenton H Whitmire, Lon J Wilson
Carbon nanotubes (CNTs) have been used for a plethora of biomedical applications, including their use as delivery vehicles for drugs, imaging agents, proteins, DNA, and other materials. Here, we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultrashort single-walled carbon nanotubes (20-80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today due to its high X-ray attenuation capability and its low toxicity, which makes bismuth a more-promising element for new CT CA design...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056938/hepatoprotective-effect-of-the-solvent-extracts-of-viola-canescens-wall-ex-roxb-against-ccl4-induced-toxicity-through-antioxidant-and-membrane-stabilizing-activity
#8
Abdullah, Mir Azam Khan, Waqar Ahmad, Manzoor Ahmad, Mohammad Nisar
BACKGROUND: Viola canescens Wall. ex. Roxb. exhibits analgesic, antimalarial and antispasmodic activities. It is used folklorically for the treatment of liver diseases, hypertension, malaria and cancer. The current study investigates phytochemical constituents, antioxidant and hepatoprotective activity of solvent extracts of whole plant of Viola canescens. METHODS: Phytochemicals, acute toxicity study and antioxidant activity of Viola canescens methanolic extract (VCME), ethyl acetate fraction (EAF), and partially purified EAF (90% EAF and combination of 80% EAF + 20% methanol fraction (EAF + Me) was carried out...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28036129/synthesis-and-in%C3%A2-vitro-bioactivity-evaluation-of-new-galactose-and-fructose-ester-derivatives-of-5-aminosalicylic-acid
#9
Samira Yousefi, Saadi Bayat, Mohd Basyaruddin Abdul Rahman, Zalikha Ibrahim, Emilia Abdulmalek
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-Aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of galactose and fructose esters of 5-ASA was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two Gram-negative and two Gram-positive species of bacteria, with a notable effect observed against Staphylococcus aureus and Escherichia coli in comparisons with the 5-ASA...
December 30, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27979084/recent-advances-on-determination-of-milk-adulterants
#10
REVIEW
Carina F Nascimento, Poliana M Santos, Edenir Rodrigues Pereira-Filho, Fábio R P Rocha
Milk adulteration is a current fraudulent practice to mask the quality parameters (e.g. protein and fat content) and increase the product shelf life. Milk adulteration includes addition of toxic substances, such as formaldehyde, hydrogen peroxide, hypochlorite, dichromate, salicylic acid, melamine, and urea. In order to assure the food safety and avoid health risks to consumers, novel analytical procedures have been proposed for detection of these adulterants. The innovations encompass sample pretreatment and improved detection and data processing, including chemometric tools...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27951421/exogenous-salicylic-acid-alleviates-the-toxicity-of-chlorpyrifos-in-wheat-plants-triticum-aestivum
#11
Caixia Wang, Qingming Zhang
The role of exogenous salicylic acid (SA) in protecting wheat plants (Triticum aestivum) from contamination by the insecticide chlorpyrifos was investigated in this study. The wheat plants were grown in soils with different concentrations (5, 10, 20, and 40mgkg(-1)) of chlorpyrifos. When the third leaf emerged, the wheat leaves were sprayed with 1, 2, 4, 8, and 16mgL(-1) of SA once a day for 6 days. The results showed that wheat exposed to higher concentrations of chlorpyrifos (≥20mgkg(-1)) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX)...
March 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27931000/thorium-impact-on-tobacco-root-transcriptome
#12
Kateřina Mazari, Přemysl Landa, Sylva Přerostová, Karel Müller, Radomíra Vaňková, Petr Soudek, Tomáš Vaněk
Thorium is natural actinide metal with potential use in nuclear energetics. Contamination by thorium, originated from mining activities or spills, represents environmental risk due to its radioactivity and chemical toxicity. A promising approach for cleaning of contaminated areas is phytoremediation, which need to be based, however, on detail understanding of the thorium effects on plants. In this study we investigated transcriptomic response of tobacco roots exposed to 200μM thorium for one week. Thorium application resulted in up-regulation of 152 and down-regulation of 100 genes (p-value <0...
March 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27867390/the-mechanisms-of-maize-resistance-to-fusarium-verticillioides-by-comprehensive-analysis-of-rna-seq-data
#13
Yanping Wang, Zijian Zhou, Jingyang Gao, Yabin Wu, Zongliang Xia, Huiyong Zhang, Jianyu Wu
Fusarium verticillioides is the most commonly reported fungal species responsible for ear rot of maize which substantially reduces grain yield. It also results in a substantial accumulation of mycotoxins that give rise to toxic response when ingested by animals and humans. For inefficient control by chemical and agronomic measures, it thus becomes more desirable to select more resistant varieties. However, the molecular mechanisms underlying the infection process remain poorly understood, which hampers the application of quantitative resistance in breeding programs...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27834107/a-critical-review-of-the-literature-to-conduct-a-toxicity-assessment-for-oral-exposure-to-methyl-salicylate
#14
Tracy Greene, Sarah Rogers, Allison Franzen, Robinan Gentry
Methyl salicylate is the predominant constituent of oil of wintergreen and is used as a pesticide, a denaturant, an external analgesic, a fragrance ingredient, and a flavoring agent in products such as chewing gum, baked goods, syrups, candy, beverages, ice cream, and tobacco products; and it occurs naturally in some vegetables and berries. Methyl salicylate is of interest to the tobacco industry as oil of wintergreen is used as a flavorant in tobacco products. The purpose of this investigation was to conduct a critical review of the available literature for oral exposure to methyl salicylate, incorporating an analysis of the quality of the studies available and the current understanding of the mode of action...
February 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27811003/nitrite-is-the-driver-phytohormones-are-modulators-while-no-and-h2o2-act-as-promoters-of-no2-induced-cell-death
#15
Dörte Kasten, Axel Mithöfer, Elisabeth Georgii, Hans Lang, Jörg Durner, Frank Gaupels
This study aimed to understand the molecular mechanisms of nitrogen dioxide (NO2)-induced toxicity and cell death in plants. Exposure of Arabidopsis to high concentrations of NO2 induced cell death in a dose-dependent manner. No leaf symptoms were visible after fumigation for 1 h with 10 parts per million (ppm) NO2 However, 20 ppm NO2 caused necrotic lesion formation and 30 ppm NO2 complete leaf collapse, which had already started during the 1 h fumigation period. NO2 fumigation resulted in a massive accumulation of nitrite and in protein modifications by S-nitrosylation and tyrosine nitration...
November 2, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27776888/polyfluorinated-salicylic-acid-derivatives-as-analogs-of-known-drugs-synthesis-molecular-docking-and-biological-evaluation
#16
E V Shchegol'kov, I V Shchur, Ya V Burgart, V I Saloutin, A N Trefilova, G A Ljushina, S Yu Solodnikov, L N Markova, V V Maslova, O P Krasnykh, S S Borisevich, S L Khursan
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
January 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27750140/seasonal-changes-in-antioxidative-oxidative-profile-of-mining-and-non-mining-populations-of-syrian-beancaper-as-determined-by-soil-conditions
#17
Antonio López-Orenes, María C Bueso, Héctor M Conesa, Antonio A Calderón, María A Ferrer
Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed. Successful plant establishment in multi-polluted soils can be hampered not only by HMM toxicities, but also by soil nutrient deficiencies and the co-occurrence of abiotic stresses. Some plant species are able to thrive under these multi-stress scenarios often linked to marked fluctuations in environmental factors. This study aimed to investigate the metabolic adjustments involved in Zygophyllum fabago acclimative responses to conditions prevailing in HMM-enriched mine-tailings piles, during Mediterranean spring and summer...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27749632/delayed-salicylate-toxicity-in-a-17-year-old-girl-with-initially-undetectable-salicylate-concentration-3-9-hours-after-ingestion
#18
Gillian A Beauchamp, Robert G Hendrickson
We report the case of a 17-year-old girl with a 126-mg/kg nonenteric coated aspirin ingestion with nontoxic salicylate concentrations at 1.5 and 3.9 hours postingestion, who developed tinnitus and vomiting an estimated 8 hours postingestion, and who was subsequently found to have a toxic salicylate concentration at 22.7 hours postingestion. This case, as well as previous cases of delayed aspirin therapy, may prompt providers to consider educating patients and their care providers regarding the need to return for further testing if symptoms, such as vomiting or tinnitus, develop after an aspirin ingestion...
September 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27742359/fumigant-and-contact-toxicity-of-22-wooden-essential-oils-and-their-major-components-against-drosophila-suzukii-diptera-drosophilidae
#19
Junheon Kim, Miyeon Jang, Eunsik Shin, Jeongmin Kim, Si Hyeock Lee, Chung Gyoo Park
Fumigant and contact toxicities of 22 plant essential oils (EOs) from 14 families and their constituents against the adult spotted wing drosophila (SWD), Drosophila suzukii were examined. Analyses by GC, GC-MS, and NMR led to the identification of 2, 16, 13, 4, 6, 9, and 10 compounds from Gaultheria fragrantissima, Croton anistatum, Illicium verum, Liquidamabar orientalis, Cinnamomum cassia, Rosa damasena, and Santalum album, respectively. In fumigant toxicity test, G. fragrantissima, C. anistatum, and I. verum exhibited 100, 93...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27718063/strategies-of-chemical-anti-predator-defences-in-leaf-beetles-is-sequestration-of-plant-toxins-less-costly-than-de-novo-synthesis
#20
Elena L Zvereva, Vitali Zverev, Oksana Y Kruglova, Mikhail V Kozlov
The evolution of defensive traits is driven both by benefits gained from protection against enemies and by costs of defence production. We tested the hypothesis that specialisation of herbivores on toxic host plants, accompanied by the ability to acquire plant defensive compounds for herbivore defence, is favoured by the lower costs of sequestration compared to de novo synthesis of defensive compounds. We measured physiological costs of chemical defence as a reduction in larval performance in response to repeated removal of secretions (simulating predator attack) and compared these costs between five species synthesising defences de novo and three species sequestering salicylic glucosides (SGs) from their host plants...
October 7, 2016: Oecologia
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