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Salicylate toxicity

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https://www.readbyqxmd.com/read/27931000/thorium-impact-on-tobacco-root-transcriptome
#1
Kateřina Mazari, Přemysl Landa, Sylva Přerostová, Karel Müller, Radomíra Vaňková, Petr Soudek, Tomáš Vaněk
Thorium is natural actinide metal with potential use in nuclear energetics. Contamination by thorium, originated from mining activities or spills, represents environmental risk due to its radioactivity and chemical toxicity. A promising approach for cleaning of contaminated areas is phytoremediation, which need to be based, however, on detail understanding of the thorium effects on plants. In this study we investigated transcriptomic response of tobacco roots exposed to 200μM thorium for one week. Thorium application resulted in up-regulation of 152 and down-regulation of 100 genes (p-value <0...
November 30, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27867390/the-mechanisms-of-maize-resistance-to-fusarium-verticillioides-by-comprehensive-analysis-of-rna-seq-data
#2
Yanping Wang, Zijian Zhou, Jingyang Gao, Yabin Wu, Zongliang Xia, Huiyong Zhang, Jianyu Wu
Fusarium verticillioides is the most commonly reported fungal species responsible for ear rot of maize which substantially reduces grain yield. It also results in a substantial accumulation of mycotoxins that give rise to toxic response when ingested by animals and humans. For inefficient control by chemical and agronomic measures, it thus becomes more desirable to select more resistant varieties. However, the molecular mechanisms underlying the infection process remain poorly understood, which hampers the application of quantitative resistance in breeding programs...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27834107/a-critical-review-of-the-literature-to-conduct-a-toxicity-assessment-for-oral-exposure-to-methyl-salicylate
#3
Tracy Greene, Sarah Rogers, Allison Franzen, Robinan Gentry
Methyl salicylate is the predominant constituent of oil of wintergreen and is used as a pesticide, a denaturant, an external analgesic, a fragrance ingredient, and a flavoring agent in products such as chewing gum, baked goods, syrups, candy, beverages, ice cream, and tobacco products; and it occurs naturally in some vegetables and berries. Methyl salicylate is of interest to the tobacco industry as oil of wintergreen is used as a flavorant in tobacco products. The purpose of this investigation was to conduct a critical review of the available literature for oral exposure to methyl salicylate, incorporating an analysis of the quality of the studies available and the current understanding of the mode of action...
November 11, 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27811003/nitrite-is-the-driver-phytohormones-are-modulators-while-no-and-h2o2-act-as-promoters-of-no2-induced-cell-death
#4
Dörte Kasten, Axel Mithöfer, Elisabeth Georgii, Hans Lang, Jörg Durner, Frank Gaupels
This study aimed to understand the molecular mechanisms of nitrogen dioxide (NO2)-induced toxicity and cell death in plants. Exposure of Arabidopsis to high concentrations of NO2 induced cell death in a dose-dependent manner. No leaf symptoms were visible after fumigation for 1 h with 10 parts per million (ppm) NO2 However, 20 ppm NO2 caused necrotic lesion formation and 30 ppm NO2 complete leaf collapse, which had already started during the 1 h fumigation period. NO2 fumigation resulted in a massive accumulation of nitrite and in protein modifications by S-nitrosylation and tyrosine nitration...
November 2, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27776888/polyfluorinated-salicylic-acid-derivatives-as-analogs-of-known-drugs-synthesis-molecular-docking-and-biological-evaluation
#5
E V Shchegol'kov, I V Shchur, Ya V Burgart, V I Saloutin, A N Trefilova, G A Ljushina, S Yu Solodnikov, L N Markova, V V Maslova, O P Krasnykh, S S Borisevich, S L Khursan
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
October 12, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27750140/seasonal-changes-in-antioxidative-oxidative-profile-of-mining-and-non-mining-populations-of-syrian-beancaper-as-determined-by-soil-conditions
#6
Antonio López-Orenes, María C Bueso, Héctor M Conesa, Antonio A Calderón, María A Ferrer
Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed. Successful plant establishment in multi-polluted soils can be hampered not only by HMM toxicities, but also by soil nutrient deficiencies and the co-occurrence of abiotic stresses. Some plant species are able to thrive under these multi-stress scenarios often linked to marked fluctuations in environmental factors. This study aimed to investigate the metabolic adjustments involved in Zygophyllum fabago acclimative responses to conditions prevailing in HMM-enriched mine-tailings piles, during Mediterranean spring and summer...
October 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27749632/delayed-salicylate-toxicity-in-a-17-year-old-girl-with-initially-undetectable-salicylate-concentration-3-9-hours-after-ingestion
#7
Gillian A Beauchamp, Robert G Hendrickson
We report the case of a 17-year-old girl with a 126-mg/kg nonenteric coated aspirin ingestion with nontoxic salicylate concentrations at 1.5 and 3.9 hours postingestion, who developed tinnitus and vomiting an estimated 8 hours postingestion, and who was subsequently found to have a toxic salicylate concentration at 22.7 hours postingestion. This case, as well as previous cases of delayed aspirin therapy, may prompt providers to consider educating patients and their care providers regarding the need to return for further testing if symptoms, such as vomiting or tinnitus, develop after an aspirin ingestion...
September 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27742359/fumigant-and-contact-toxicity-of-22-wooden-essential-oils-and-their-major-components-against-drosophila-suzukii-diptera-drosophilidae
#8
Junheon Kim, Miyeon Jang, Eunsik Shin, Jeongmin Kim, Si Hyeock Lee, Chung Gyoo Park
Fumigant and contact toxicities of 22 plant essential oils (EOs) from 14 families and their constituents against the adult spotted wing drosophila (SWD), Drosophila suzukii were examined. Analyses by GC, GC-MS, and NMR led to the identification of 2, 16, 13, 4, 6, 9, and 10 compounds from Gaultheria fragrantissima, Croton anistatum, Illicium verum, Liquidamabar orientalis, Cinnamomum cassia, Rosa damasena, and Santalum album, respectively. In fumigant toxicity test, G. fragrantissima, C. anistatum, and I. verum exhibited 100, 93...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27718063/strategies-of-chemical-anti-predator-defences-in-leaf-beetles-is-sequestration-of-plant-toxins-less-costly-than-de-novo-synthesis
#9
Elena L Zvereva, Vitali Zverev, Oksana Y Kruglova, Mikhail V Kozlov
The evolution of defensive traits is driven both by benefits gained from protection against enemies and by costs of defence production. We tested the hypothesis that specialisation of herbivores on toxic host plants, accompanied by the ability to acquire plant defensive compounds for herbivore defence, is favoured by the lower costs of sequestration compared to de novo synthesis of defensive compounds. We measured physiological costs of chemical defence as a reduction in larval performance in response to repeated removal of secretions (simulating predator attack) and compared these costs between five species synthesising defences de novo and three species sequestering salicylic glucosides (SGs) from their host plants...
October 7, 2016: Oecologia
https://www.readbyqxmd.com/read/27676096/evaluation-of-chromane-based-bryostatin-analogues-prepared-via-hydrogen-mediated-c-c-bond-formation-potency-does-not-confer-bryostatin-like-biology
#10
John M Ketcham, Ivan Volchkov, Te-Yu Chen, Peter M Blumberg, Noemi Kedei, Nancy E Lewin, Michael J Krische
The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2-WN-7 and the previously reported salicylate-based analogue WN-8 are described. Analogues WN-2-WN-7 are prepared through convergent assembly of the chromane-containing fragment B-I with the "binding domain" fragment A-I or its C26-des-methyl congener, fragment A-II. The synthesis of fragment B-I features enantioselective double C-H allylation of 1,3-propanediol to form the C2-symmetric diol 3 and Heck cyclization of bromo-diene 5 to form the chromane core...
October 12, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27667541/production-and-characterization-of-polycaprolactone-hyaluronic-acid-chitosan-zein-electrospun-bilayer-nanofibrous-membrane-for-tissue-regeneration
#11
Daniela R Figueira, Sónia P Miguel, Kevin D de Sá, Ilídio J Correia
A bilayered electrospun membrane was produced in this study, using the electrospinning technique, to be applied as a skin substitute. The upper layer of the membrane was comprised by hyaluronic acid and polycaprolactone in order to provide mechanical support and also to act as a physical barrier against external threats. Chitosan and zein were used to produce the bottom layer that was loaded with salicylic acid, in order to confer anti-inflammatory and antimicrobial activity to this layer. The physicochemical properties of the membranes were determined and the obtained results showed that the produced electrospun membrane display an ideal porosity, appropriate mechanical properties, controlled water loss and a suitable salicylic acid release profile...
September 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27581631/different-spectrophotometric-and-tlc-densitometric-methods-for-determination-of-mesalazine-in-presence-of-its-two-toxic-impurities
#12
Martha Moheb Morcoss, Nada Sayed Abdelwahab, Nouruddin Wagieh Ali, Mohammed Taha Elsaady
Two selective spectrophotometric and TLC-densitometric methods were developed for determination of mesalazine (ME) and its two toxic impurities, 4-amino phenol (4AP) and salicylic acid (SA) without preliminary separation. The proposed methods are: ratio difference in the subtracted spectra (RDSS) {Method 1}, area under the curve (AUC) {Method 2} and TLC-densitometric {Method 3}. In method {1} combination of measuring the amplitude of the constant at 350 nm (using standard spectrum of 10 µg/mL ME as a divisor) and ratio difference in the subtracted ratio spectrum for determination of 4AP and SA using the ratio difference at 221...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27580341/structural-and-kinetic-properties-of-the-aldehyde-dehydrogenase-nahf-a-broad-substrate-specificity-enzyme-for-aldehyde-oxidation
#13
Juliana B Coitinho, Mozart S Pereira, Débora M A Costa, Samuel L Guimarães, Simara S Araújo, Alvan C Hengge, Tiago A S Brandão, Ronaldo A P Nagem
The salicylaldehyde dehydrogenase (NahF) catalyzes the oxidation of salicylaldehyde to salicylate using NAD(+) as a cofactor, the last reaction of the upper degradation pathway of naphthalene in Pseudomonas putida G7. The naphthalene is an abundant and toxic compound in oil and has been used as a model for bioremediation studies. The steady-state kinetic parameters for oxidation of aliphatic or aromatic aldehydes catalyzed by 6xHis-NahF are presented. The 6xHis-NahF catalyzes the oxidation of aromatic aldehydes with large kcat/Km values close to 10(6) M(-1) s(-1)...
September 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27575042/combined-ability-of-chromium-cr-tolerant-plant-growth-promoting-bacteria-pgpb-and-salicylic-acid-sa-in-attenuation-of-chromium-stress-in-maize-plants
#14
Faisal Islam, Tahira Yasmeen, Muhammad Saleem Arif, Muhammad Riaz, Sher Muhammad Shahzad, Qaiser Imran, Irfan Ali
Heavy metal contamination of agricultural soil has become a serious global problem. This study was aimed to evaluate the effects of two chromium (Cr) tolerant plant growth promoting bacteria (PGPB) in combination with salicylic acid (SA) on plant growth, physiological, biochemical responses and heavy metal uptake under Cr contamination. A pot experiment (autoclaved sand as growing medium) was performed using maize (Zea mays L.) as a test crop under controlled conditions. Cr toxicity significantly reduced plant growth, photosynthetic pigment, carbohydrates metabolism and increased H2O2, MDA, relative membrane permeability, proline and Cr contents in maize leaves...
August 18, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27553001/phytotoxicity-of-15-common-pharmaceuticals-on-the-germination-of-lactuca-sativa-and-photosynthesis-of-chlamydomonas-reinhardtii
#15
Ma Rosa Pino, Selene Muñiz, Jonatan Val, Enrique Navarro
Pharmaceuticals reach terrestrial environments through the application of treated wastewaters and biosolids to agricultural soils. We have investigated the toxicity of 15 common pharmaceuticals, classified as nonsteroidal anti-inflammatory drugs (NSAIDs), blood lipid-lowering agents, β-blockers and antibiotics, in two photosynthetic organisms. Twelve pharmaceuticals caused inhibitory effects on the radicle and hypocotyl elongation of Lactuca sativa seeds. The EC50 values obtained were in the range of 170-5656 mg L(-1) in the case of the radicle and 188-4558 mg L(-1) for the hypocotyl...
August 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27531848/use-of-continuous-renal-replacement-therapy-in-salicylate-toxicity-a-case-report-and-review-of-the-literature
#16
Michael F Papacostas, Margaret Hoge, Michel Baum, Samuel Z Davila
OBJECTIVE: To report a case of salicylate toxicity treated with continuous venovenous hemodiafiltration (CVVHDF) and review the literature regarding the use of continuous renal replacement therapy (CRRT) for salicylate toxicity. CASE: A 16-year-old male presented after ingesting 1901 mg/kg of enteric coated aspirin. Salicylate level was 92 mg/dl 4 h after ingestion. Sequele included seizure, acute kidney injury, pulmonary edema, and prolonged QTc. He received 5...
September 2016: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/27524054/mgal-layered-double-hydroxide-nanoparticles-for-controlled-release-of-salicylate
#17
Soumini Mondal, Sudip Dasgupta, Kanchan Maji
Layered double hydroxides (LDHs), have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, and additives for polymers. Recently, their successful synthesis on the nanometer scale opened up a whole new field for their application in nanomedicine. Here we report the efficacy of Mg1-xAlx (NO3)x (OH)2 LDH nanoparticles as a carrier and for controlled release of one of the non-steroidal anti-inflammatory drugs (NSAID), sodium salicylate. Mg1-xAlx (NO3)x (OH)2.nH2O nanoparticles were synthesized using co-precipitation method from an aqueous solution of Mg(NO3)2...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27515206/aspirin-for-cancer-is-no-mere-antiplatelet-prototype-there-is-potential-in-its-ancient-roots
#18
James R Lawrence, Gwendoline J Baxter, John R Paterson
Aspirin (ASA), increasingly accepted as predominantly a cyclooxygenase (COX)-1 inhibitor, is a prodrug for salicylic acid (SA) which has no such activity. SA is widespread in nature, vital in plants, and present in drug free serum from animals and man. Evolutionary conserved SA receptors are found in human tissues. Very low doses of ASA will, on repeat dosing, produce near maximal platelet COX-1 inhibition. Evidence for cancer prophylaxis is based on ASA doses of at least 75mg/day. Pleiotropic mechanisms underlie low dose ASA's undoubted efficacy in preventive medicine but the key barrier to its more widespread use is gastrointestinal toxicity...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27490102/salicylic-acid-and-sodium-salicylate-alleviate-cadmium-toxicity-to-different-extents-in-maize-zea-mays-l
#19
Orsolya Kinga Gondor, Magda Pál, Éva Darkó, Tibor Janda, Gabriella Szalai
The role of salicylic acid in Cd tolerance has attracted more attention recently but no information is available on the efficiency of different forms of salicylic acid. The aim was thus to investigate whether both the acid and salt forms of salicylic acid provide protection against Cd stress and to compare their mode of action. Young maize plants were grown under controlled environmental conditions. One group of 10-day-old seedlings were treated with 0.5 mM SA or NaSA for 1 day then half of the pants were treated with 0...
2016: PloS One
https://www.readbyqxmd.com/read/27484946/comparative-metagenomic-analysis-of-pah-degradation-in-soil-by-a-mixed-microbial-consortium
#20
German Zafra, Todd D Taylor, Angel E Absalón, Diana V Cortés-Espinosa
In this study, we used a taxonomic and functional metagenomic approach to analyze some of the effects (e.g. displacement, permanence, disappearance) produced between native microbiota and a previously constructed Polycyclic Aromatic Hydrocarbon (PAH)-degrading microbial consortium during the bioremediation process of a soil polluted with PAHs. Bioaugmentation with a fungal-bacterial consortium and biostimulation of native microbiota using corn stover as texturizer produced appreciable changes in the microbial diversity of polluted soils, shifting native microbial communities in favor of degrading specific populations...
November 15, 2016: Journal of Hazardous Materials
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