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Alcohol and glutamate

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https://www.readbyqxmd.com/read/29753887/peri-adolescent-drinking-of-ethanol-and-or-nicotine-modulates-astroglial-glutamate-transporters-and-metabotropic-glutamate-receptor-1-in-female-alcohol-preferring-rats
#1
Fawaz Alasmari, Richard L Bell, P S S Rao, Alaa M Hammad, Youssef Sari
Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicated that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-1 (GLT-1) and cystine/glutamate antiporter (xCT) but not the glutamate/aspartate transporter (GLAST). Additionally, metabotropic glutamate receptors (mGluRs) expression was affected following exposure to EtOH or NIC. However, little is known about the effects of EtOH and NIC co-consumption on GLT-1, xCT, GLAST, and mGluR1 expression...
May 10, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29748627/deficient-endocannabinoid-signaling-in-the-central-amygdala-contributes-to-alcohol-dependence-related-anxiety-like-behavior-and-excessive-alcohol-intake
#2
Antonia Serrano, Francisco J Pavon, Matthew W Buczynski, Joel Schlosburg, Luis A Natividad, Ilham Y Polis, David G Stouffer, Eric P Zorrilla, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodriguez de Fonseca, Loren H Parsons
Negative emotional states that are associated with excessive alcohol intake, particularly anxiety-like states, have been linked to opponent processes in the central nucleus of the amygdala (CeA), affecting stress-related transmitters and monoamines. This study extends these observations to include endocannabinoid signaling in alcohol-dependent animals. Rats and mice were exposed to chronic intermittent alcohol with vapor inhalation or liquid diet to induce dependence. In vivo microdialysis was used to estimate interstitial concentrations of endocannabinoids [N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG)] and amino acids (glutamate and GABA) in rat CeA...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29741618/fermentation-performances-and-aroma-production-of-non-conventional-wine-yeasts-are-influenced-by-nitrogen-preferences
#3
Stéphanie Rollero, Audrey Bloem, Anne Ortiz-Julien, Carole Camarasa, Benoit Divol
Saccharomyces cerevisiae is currently the most important yeast involved in food fermentations, particularly in oenology. However, several other yeast species occur naturally in grape must that are highly promising for diversifying and improving the aromatic profile of wines. If the nitrogen requirement of S. cerevisiae has been described in detail, those of non-Saccharomyces yeasts remain poorly studied despite their increasingly widespread use in winemaking. With a view to improving the use of non-Saccharomyces yeasts in winemaking, we explored the fermentation performances, the utilization of nitrogen sources and the volatile compound production of ten strains of non-conventional yeasts in pure culture...
May 7, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29738804/alcohol-aggravates-ketamine-induced-behavioral-morphological-and-neurochemical-alterations-in-adolescent-rats-the-involvement-of-creb-related-pathways
#4
Daiying Zuo, Yumiao Liu, Zi Liu, Jiahui Cui, Xuejiao Zhou, Yang Liu, Zengqiang Li, Yingliang Wu
Currently, an increasing proportion of adolescent ketamine users simultaneously consume alcohol. However, the potential behavioural and neurological alterations induced by such a drug combination and the underlying mechanisms have not been systematically examined. Therefore, in the present study, the behavioural and morphological changes and the underlying mechanisms were studied in adolescent rats after repeated alcohol and/or ketamine treatment. This study provided the first evidence that co-administration of alcohol (2 and 4 g/kg, i...
May 5, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29692648/effects-of-different-components-of-mao-dongqing-s-total-flavonoids-and-total-saponins-on-transient-ischemic-attack-tia-model-of-rats
#5
Ming-San Miao, Meng-Fan Peng, Rui-Juan Ma, Ming Bai, Bao-Song Liu
Objective: To study the effects of the different components of the total flavonoids and total saponins from Mao Dongqing's active site on the rats of TIA model, determine the optimal reactive components ratio of Mao Dongqing on the rats of TIA. Methods: TIA rat model was induced by tail vein injection of tert butyl alcohol, the blank group was injected with the same amount of physiological saline, then behavioral score wasevaluated. Determination the level of glutamic acid in serum, the activity of Na+-K+-ATP enzyme, CA++ -ATP enzyme and Mg++ -ATP enzyme in Brain tissue, observe the changes of hippocampus in brain tissue, the comprehensive weight method was used to evaluate the efficacy of each component finally...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29688328/ethanol-exposure-in-utero-disrupts-radial-migration-and-pyramidal-cell-development-in-the-somatosensory-cortex
#6
Laurie C Delatour, Pamela W Yeh, Hermes H Yeh
Deficits in sensory processing in Fetal Alcohol Spectrum Disorders (FASD) implicate dysfunction in the somatosensory cortex. However, the effects of prenatal ethanol exposure on the development of this region await elucidation. Here, we used an established mouse model of FASD with binge-type ethanol exposure from embryonic day 13.5-16.5 to investigate the effects of prenatal ethanol exposure on pyramidal neurons in the somatosensory cortex. Specifically, we focused on the radial migration of primordial pyramidal neurons during embryonic corticogenesis and their morphology and function during active synaptogenesis in early postnatal development...
April 24, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29686143/elevation-of-cytosolic-ca-2-in-response-to-energy-deficiency-in-plants-the-general-mechanism-of-adaptation-to-low-oxygen-stress
#7
REVIEW
Abir U Igamberdiev, Robert D Hill
Ca2+ can be released from cell compartments to the cytosol during stress conditions. We discuss here the causes of Ca2+ release under conditions of ATP concentration decline that result in the suppression of ATPases and activation of calcium ion channels. The main signaling and metabolic consequences of Ca2+ release are considered for stressed plant cells. The signaling function includes generation and spreading of calcium waves, while the metabolic function results in the activation of particular enzymes and genes...
April 23, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29675583/do-alcohol-related-ampa-type-glutamate-receptor-adaptations-promote-intake
#8
F Woodward Hopf, Regina A Mangieri
Ionotropic glutamate receptors (AMPA, NMDA, and kainate receptors) play a central role in excitatory glutamatergic signaling throughout the brain. As a result, functional changes, especially long-lasting forms of plasticity, have the potential to profoundly alter neuronal function and the expression of adaptive and pathological behaviors. Thus, alcohol-related adaptations in ionotropic glutamate receptors are of great interest, since they could promote excessive alcohol consumption, even after long-term abstinence...
April 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29674969/-in-vitro-functional-characterization-of-get73-as-possible-negative-allosteric-modulator-of-metabotropic-glutamate-receptor-5
#9
Sarah Beggiato, Andrea C Borelli, Maria C Tomasini, M Paola Castelli, Nicholas Pintori, Roberto Cacciaglia, Antonella Loche, Luca Ferraro
The present study was aimed to further characterize the pharmacological profile of N-[4-(trifluoromethyl) benzyl]-4-methoxybutyramide (GET73), a putative negative allosteric modulator (NAM) of metabotropic glutamate subtype 5 receptor (mGluR5) under development as a novel medication for the treatment of alcohol dependence. This aim has been accomplished by means of a series of in vitro functional assays. These assays include the measure of several down-stream signaling [intracellular Ca++ levels, inositol phosphate (IP) formation and CREB phosphorylation (pCREB)] which are generally affected by mGluR5 ligands...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674951/integrating-genetic-and-gene-co-expression-analysis-identifies-gene-networks-involved-in-alcohol-and-stress-responses
#10
Jie Luo, Pei Xu, Peijian Cao, Hongjian Wan, Xiaonan Lv, Shengchun Xu, Gangjun Wang, Melloni N Cook, Byron C Jones, Lu Lu, Xusheng Wang
Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear. The purpose of this study is to identify molecular networks underlying the effects of alcohol and stress responses, as well as their interaction on anxiety behaviors in the hippocampus of mice using a systems genetics approach. Here, we applied a gene co-expression network approach to transcriptomes of 41 BXD mouse strains under four conditions: stress, alcohol, stress-induced alcohol and control...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#11
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29665166/silencing-synaptic-microrna-411-reduces-voluntary-alcohol-consumption-in-mice
#12
Dana Most, Nihal A Salem, Gayatri R Tiwari, Yuri A Blednov, R Dayne Mayfield, R Adron Harris
Chronic alcohol consumption alters the levels of microRNAs and mRNAs in the brain, but the specific microRNAs and processes that target mRNAs to affect cellular function and behavior are not known. We examined the in vivo manipulation of previously identified alcohol-responsive microRNAs as potential targets to reduce alcohol consumption. Silencing of miR-411 by infusing antagomiR-411 into the prefrontal cortex of female C57BL/6J mice reduced alcohol consumption and preference, without altering total fluid consumption, saccharin consumption, or anxiety-related behaviors...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29628194/metabotropic-glutamate-receptor-5-as-a-target-for-the-treatment-of-depression-and-smoking-robust-preclinical-data-but-inconclusive-clinical-efficacy
#13
REVIEW
Samuel A Barnes, Douglas J Sheffler, Svetlana Semenova, Nicholas D P Cosford, Anton Bespalov
The ability of novel pharmacological compounds to improve outcomes in preclinical models is often not translated into clinical efficacy. Psychiatric disorders do not have biological boundaries, and identifying mechanisms to improve the translational bottleneck between preclinical and clinical research domains is an important and challenging task. Glutamate transmission is disrupted in several neuropsychiatric disorders. Metabotropic glutamate (mGlu) receptors represent a diverse class of receptors that contribute to excitatory neurotransmission...
March 9, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29623680/a-critical-review-of-methods-and-results-in-the-search-for-genetic-contributors-to-alcohol-sensitivity
#14
REVIEW
Marc A Schuckit
Attributes of alcohol sensitivity are present before alcohol use disorders (AUDs) develop, they predict those adverse alcohol outcomes, are familial in nature, and many are heritable. Whether measured by alcohol challenges or retrospective reports of numbers of drinks required for effects, alcohol sensitivity reflects multiple phenotypes, including low levels of alcohol response and alcohol-related stimulation. Identification of genes that contribute to alcohol sensitivity could help identify individuals carrying risks for AUDs through their alcohol responses for whom early intervention might mitigate their vulnerability...
April 5, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29615864/molecular-neuropathology-of-astrocytes-and-oligodendrocytes-in-alcohol-use-disorders
#15
REVIEW
José J Miguel-Hidalgo
Postmortem studies reveal structural and molecular alterations of astrocytes and oligodendrocytes in both the gray and white matter (GM and WM) of the prefrontal cortex (PFC) in human subjects with chronic alcohol abuse or dependence. These glial cellular changes appear to parallel and may largely explain structural and functional alterations detected using neuroimaging techniques in subjects with alcohol use disorders (AUDs). Moreover, due to the crucial roles of astrocytes and oligodendrocytes in neurotransmission and signal conduction, these cells are very likely major players in the molecular mechanisms underpinning alcoholism-related connectivity disturbances between the PFC and relevant interconnecting brain regions...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29615610/alcohol-exposure-disrupts-mu-opioid-receptor-mediated-long-term-depression-at-insular-cortex-inputs-to-dorsolateral-striatum
#16
Braulio Muñoz, Brandon M Fritz, Fuqin Yin, Brady K Atwood
Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the µ-opioid receptor (MOR) in behavioral responding for alcohol, we explored the impact of alcohol on various forms of MOR-mediated synaptic depression that we find are differentially expressed at specific DS synapses...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29614441/demonstration-of-monolignol-%C3%AE-glucosidase-activity-of-rice-os4bglu14-os4bglu16-and-os4bglu18-in-arabidopsis-thaliana-bglu45-mutant
#17
Supaporn Baiya, Bancha Mahong, Sang-Kyu Lee, Jong-Seong Jeon, James R Ketudat Cairns
The glycoside hydrolase family 1 members Os4BGlu14, Os4BGlu16, and Os4BGlu18 were proposed to be rice monolignol β-glucosidases. In vitro studies demonstrated that the Os4BGlu16 and Os4BGlu18 hydrolyze the monolignol glucosides coniferin and syringin with high efficiency compared to other substrates. The replacement of the conserved catalytic acid/base glutamate residue by a nonionizable glutamine residue in Os4BGlu14 suggested that it may be inactive as a β-glucosidase. Here, we investigated the activities of Os4BGlu14, Os4BGlu16, and Os4BGlu18 in planta by recombinant expression of their genes in the Arabidopsis bglu45-2 (monolignol β-glucosidase) mutant and analysis of monolignol glucosides by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MSMS)...
March 28, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29607219/lactic-acid-bacteria-isolated-from-japanese-fermented-fish-funa-sushi-inhibit-mesangial-proliferative-glomerulonephritis-by-alcohol-intake-with-stress
#18
Yumiko Yamada, Masumi Endou, Shunichi Morikawa, Jun Shima, Noriko Komatshzaki
The aim of this study was to examine the effect of heat-killed Lactobacillus paracasei NFRI 7415 on kidney and bone in mice fed an ethanol-containing diet with stress. Eight-week-old Cril  :  CD1 mice were fed a control diet (CD), an alcohol diet (AD) (35.8% of total energy from ethanol), or an alcohol diet containing 20% heat-killed Lb. paracasei NFRI 7415 (107  CFU/g) (LD) for 4 weeks. Mice in the AD and LD groups also underwent restraint stress for two weeks from 13 days. The mice were placed in a 50 mL plastic tube, which had a small hole drilled around its base to allow ventilation, and restrained for 1 h every day...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29606448/fermentation-process-optimization-and-chemical-constituent-analysis-on-longan-dimocarpus-longan-lour-wine
#19
Guoming Liu, Jian Sun, Xuemei He, Yayuan Tang, Jiemin Li, Dongning Ling, Changbao Li, Li Li, Fengjin Zheng, Jingfeng Sheng, Ping Wei, Ming Xin
Based on single factor and orthogonal experiments, optimal fermentation conditions for longan wine were Saccharomyces cerevisiae strain of Lalvin KD , juice content of 70% and alcohol content of 10°. Sixteen amino acids were detected. Proline, alanine, glutamic acid and aspartic acid contents were relatively high. Sixty-three volatile aroma compounds were identified using solid-phase micro extraction and gas chromatography (SPME-GC). Ethyl lactate content was the highest, followed by octanoic acid ethyl ester, isoamyl alcohol and decanoic acid ethyl ester...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29604365/effects-of-ceftriaxone-on-hydrocodone-seeking-behavior-and-glial-glutamate-transporters-in-p-rats
#20
Fahad S Alshehri, Alqassem Y Hakami, Yusuf S Althobaiti, Youssef Sari
Hydrocodone (HYD) is one of the most widely prescribed opioid analgesic drugs. Several neurotransmitters are involved in opioids relapse. Among these neurotransmitters, glutamate is suggested to be involved in opioid dependence and relapse. Glutamate is regulated by several glutamate transporters, including glutamate transporter 1 (GLT-1) and cystine/glutamate transporter (xCT). In this study, we investigated the effects of ceftriaxone (CEF) (200 mg/kg, i.p.), known to upregulate GLT-1 and xCT, on reinstatement to HYD (5 mg/kg, i...
March 28, 2018: Behavioural Brain Research
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